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Conserved domains on  [gi|2462625914|ref|XP_054219524|]
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sushi domain-containing protein 1 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
125-156 1.56e-09

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.02  E-value: 1.56e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462625914  125 DIDECEVSGLCRHGGRCVNTHGSFECYCMDGY 156
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
73-111 1.16e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462625914   73 DKNECQFGAtlVCGNHTSCHNTPGGFYCICLEGYRATNN 111
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 179-235 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462625914 179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHCQ 235
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 239-294 2.67e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 41.68  E-value: 2.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914 239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFEsPGGKITSVCTEKGTWRESTLTC 294
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 42-69 6.99e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 6.99e-04
                          10        20
                  ....*....|....*....|....*...
gi 2462625914  42 CHEHATCQQREGKKICICNYGFVGNGRT 69
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVT 35
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
125-156 1.56e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.02  E-value: 1.56e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462625914  125 DIDECEVSGLCRHGGRCVNTHGSFECYCMDGY 156
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 125-160 7.79e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 7.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462625914 125 DIDECEVSGLCRHGGRCVNTHGSFECYCMDGYLPRN 160
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
73-111 1.16e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462625914   73 DKNECQFGAtlVCGNHTSCHNTPGGFYCICLEGYRATNN 111
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 179-235 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462625914 179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHCQ 235
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
179-234 1.80e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.10  E-value: 1.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914 179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHC 234
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGSPTI-TCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 239-294 2.67e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 41.68  E-value: 2.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914 239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFEsPGGKITSVCTEKGTWRESTLTC 294
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 179-234 2.98e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 2.98e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914  179 CGTPPEVPDGYIIG-NYTSSLGSQVRYACREGFFSVPEDTvSSCTGLGTWESPKLHC 234
Cdd:smart00032   1 CPPPPDIENGTVTSsSGTYSYGDTVTYSCDPGYTLIGSST-ITCLENGTWSPPPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 73-110 3.90e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462625914  73 DKNECQFGAtlVCGNHTSCHNTPGGFYCICLEGYRATN 110
Cdd:cd00054     1 DIDECASGN--PCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
125-155 2.39e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 2.39e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462625914 125 DIDECEVSG-LCRHGGRCVNTHGSFECYCMDG 155
Cdd:pfam07645   1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 146-294 2.77e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625914 146 GSFECYCMDGYlprNGPEPFHPttDATSCTEIDCGTPPEVPDGYIIGN---YTSslGSQVRYACREGfFSVPEDTVSSCT 222
Cdd:PHA02927  120 GESKSYCELGS---TGSMVWNP--EAPICESVKCQSPPSISNGRHNGYedfYTD--GSVVTYSCNSG-YSLIGNSGVLCS 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462625914 223 GlGTWESPKLhCQEINCGNPPEMRHAILVG-NHSSRLGGVARYVCQEGFESPGGKiTSVCTEKGTWRESTLTC 294
Cdd:PHA02927  192 G-GEWSDPPT-CQIVKCPHPTISNGYLSSGfKRSYSYNDNVDFKCKYGYKLSGSS-SSTCSPGNTWQPELPKC 261
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 239-294 2.80e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 2.80e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914  239 CGNPPEMRHA-ILVGNHSSRLGGVARYVCQEGFESPGGKiTSVCTEKGTWRESTLTC 294
Cdd:smart00032   1 CPPPPDIENGtVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGTWSPPPPTC 56
EGF_CA pfam07645
Calcium-binding EGF domain;
73-105 6.97e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 6.97e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462625914  73 DKNECQFGaTLVCGNHTSCHNTPGGFYCICLEG 105
Cdd:pfam07645   1 DVDECATG-THNCPANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 42-69 6.99e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 6.99e-04
                          10        20
                  ....*....|....*....|....*...
gi 2462625914  42 CHEHATCQQREGKKICICNYGFVGNGRT 69
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVT 35
Sushi pfam00084
Sushi repeat (SCR repeat);
239-294 1.48e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 36.71  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914 239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFESPGGkITSVCTEKGTWRESTLTC 294
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGS-PTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
125-156 1.56e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.02  E-value: 1.56e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462625914  125 DIDECEVSGLCRHGGRCVNTHGSFECYCMDGY 156
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 125-160 7.79e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 7.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462625914 125 DIDECEVSGLCRHGGRCVNTHGSFECYCMDGYLPRN 160
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
73-111 1.16e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462625914   73 DKNECQFGAtlVCGNHTSCHNTPGGFYCICLEGYRATNN 111
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 179-235 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 1.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462625914 179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHCQ 235
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
179-234 1.80e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.10  E-value: 1.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914 179 CGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVsSCTGLGTWESPKLHC 234
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGSPTI-TCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 239-294 2.67e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 41.68  E-value: 2.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914 239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFEsPGGKITSVCTEKGTWRESTLTC 294
Cdd:cd00033     1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 179-234 2.98e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 41.36  E-value: 2.98e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914  179 CGTPPEVPDGYIIG-NYTSSLGSQVRYACREGFFSVPEDTvSSCTGLGTWESPKLHC 234
Cdd:smart00032   1 CPPPPDIENGTVTSsSGTYSYGDTVTYSCDPGYTLIGSST-ITCLENGTWSPPPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 73-110 3.90e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462625914  73 DKNECQFGAtlVCGNHTSCHNTPGGFYCICLEGYRATN 110
Cdd:cd00054     1 DIDECASGN--PCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 128-156 5.51e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.15  E-value: 5.51e-05
                          10        20
                  ....*....|....*....|....*....
gi 2462625914 128 ECEVSGLCRHGGRCVNTHGSFECYCMDGY 156
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGY 29
EGF_CA pfam07645
Calcium-binding EGF domain;
125-155 2.39e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 2.39e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462625914 125 DIDECEVSG-LCRHGGRCVNTHGSFECYCMDG 155
Cdd:pfam07645   1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 146-294 2.77e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625914 146 GSFECYCMDGYlprNGPEPFHPttDATSCTEIDCGTPPEVPDGYIIGN---YTSslGSQVRYACREGfFSVPEDTVSSCT 222
Cdd:PHA02927  120 GESKSYCELGS---TGSMVWNP--EAPICESVKCQSPPSISNGRHNGYedfYTD--GSVVTYSCNSG-YSLIGNSGVLCS 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462625914 223 GlGTWESPKLhCQEINCGNPPEMRHAILVG-NHSSRLGGVARYVCQEGFESPGGKiTSVCTEKGTWRESTLTC 294
Cdd:PHA02927  192 G-GEWSDPPT-CQIVKCPHPTISNGYLSSGfKRSYSYNDNVDFKCKYGYKLSGSS-SSTCSPGNTWQPELPKC 261
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 239-294 2.80e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 2.80e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914  239 CGNPPEMRHA-ILVGNHSSRLGGVARYVCQEGFESPGGKiTSVCTEKGTWRESTLTC 294
Cdd:smart00032   1 CPPPPDIENGtVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGTWSPPPPTC 56
EGF_CA pfam07645
Calcium-binding EGF domain;
73-105 6.97e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 6.97e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462625914  73 DKNECQFGaTLVCGNHTSCHNTPGGFYCICLEG 105
Cdd:pfam07645   1 DVDECATG-THNCPANTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 42-69 6.99e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 6.99e-04
                          10        20
                  ....*....|....*....|....*...
gi 2462625914  42 CHEHATCQQREGKKICICNYGFVGNGRT 69
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTGDGVT 35
Sushi pfam00084
Sushi repeat (SCR repeat);
239-294 1.48e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 36.71  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625914 239 CGNPPEMRHAILVGNHSS-RLGGVARYVCQEGFESPGGkITSVCTEKGTWRESTLTC 294
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGS-PTITCQEDGTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 168-294 3.53e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 39.26  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625914 168 TTDATSCTEIDCGTPPEVPDGYIIGNYTS-SLGSQVRYACREGF---FSVPEDTVSSCTGLGTWESPKLHCQEINCgNPP 243
Cdd:PHA02639   74 SNKAPFCMLKECNDPPSIINGKIYNKREMyKVGDEIYYVCNEHKgvqYSLVGNEKITCIQDKSWKPDPPICKMINC-RFP 152

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462625914 244 EMRHAILVG-------NHSSRLGgvarYVCQEGFESPGGKItSVCTEKGTWRESTLTC 294
Cdd:PHA02639  153 ALQNGYINGipsnkkfYYKTRVG----FSCKSGFDLVGEKY-STCNINATWFPSIPTC 205
PHA02817 PHA02817
EEV Host range protein; Provisional
 172-287 9.01e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 37.61  E-value: 9.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625914 172 TSCTEIDCGTPPEVPDGYIIGNYTS-SLGSQVRYACREGFFSVPEDTVSS----CTGLGTWESPKLHCQEINCgNPPEMR 246
Cdd:PHA02817   17 SLCDLNKCCYPPSIKNGYIYNKKTEyNIGSNVTFFCGNNTRGVRYTLVGEkniiCEKDGKWNKEFPVCKIIRC-RFPALQ 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462625914 247 HAILVGNHSSR---LGGVARYVCQEGFESPGGKItSVCTEKGTW 287
Cdd:PHA02817   96 NGFVNGIPDSKkfyYESEVSFSCKPGFVLIGTKY-SVCGINSSW 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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