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Conserved domains on  [gi|2462517169|ref|XP_054220852|]
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lipase member J isoform X2 [Homo sapiens]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
4-307 4.76e-45

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 158.88  E-value: 4.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169   4 SQIISYWGYPDEEYDIVTEDGYILGLYRIpywrTDNNKNLAQRV--VVYLQHGLLTSASSWISNLPNNSLGFILADAGYD 81
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRV----SSRNPRLGSQRgpPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFD 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  82 VWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFtVKQTRQEEIFYVGHSQGTTIGFITFsTISKIAERI 161
Cdd:PLN02872  110 VWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHY-VYSITNSKIFIVGHSQGTIMSLAAL-TQPNVVEMV 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169 162 KIFFALAPVFSTKYLKSPLI-RMTY-KWKSIVMAFSgnkdfLPKTSFKKFVGSKLcplqiFDKIC---LNILFMMFGYDP 236
Cdd:PLN02872  188 EAAALLCPISYLDHVTAPLVlRMVFmHLDQMVVAMG-----IHQLNFRSDVLVKL-----LDSICeghMDCNDLLTSITG 257
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517169 237 KN--LNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDlNLVHYNQTTSPLYNMTNMNVATAIW 307
Cdd:PLN02872  258 TNccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIFK-NLKLYGQVNPPAFDLSLIPKSLPLW 329
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
4-307 4.76e-45

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 158.88  E-value: 4.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169   4 SQIISYWGYPDEEYDIVTEDGYILGLYRIpywrTDNNKNLAQRV--VVYLQHGLLTSASSWISNLPNNSLGFILADAGYD 81
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRV----SSRNPRLGSQRgpPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFD 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  82 VWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFtVKQTRQEEIFYVGHSQGTTIGFITFsTISKIAERI 161
Cdd:PLN02872  110 VWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHY-VYSITNSKIFIVGHSQGTIMSLAAL-TQPNVVEMV 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169 162 KIFFALAPVFSTKYLKSPLI-RMTY-KWKSIVMAFSgnkdfLPKTSFKKFVGSKLcplqiFDKIC---LNILFMMFGYDP 236
Cdd:PLN02872  188 EAAALLCPISYLDHVTAPLVlRMVFmHLDQMVVAMG-----IHQLNFRSDVLVKL-----LDSICeghMDCNDLLTSITG 257
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517169 237 KN--LNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDlNLVHYNQTTSPLYNMTNMNVATAIW 307
Cdd:PLN02872  258 TNccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIFK-NLKLYGQVNPPAFDLSLIPKSLPLW 329
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
3-66 4.23e-24

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 93.37  E-value: 4.23e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517169   3 ISQIISYWGYPDEEYDIVTEDGYILGLYRIPYWRTdNNKNLAQRVVVYLQHGLLTSASSWISNL 66
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRN-NSNGKGGKPVVLLQHGLLASSDNWVTNG 63
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-187 2.24e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 53.85  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  13 PDEEYDIVTEDGYilglyRIPYWRTDNNKNlAQRVVVYLqHGLLTSASSWisnlpnNSLGFILADAGYDVWMGNSRGNTW 92
Cdd:COG2267     2 TRRLVTLPTRDGL-----RLRGRRWRPAGS-PRGTVVLV-HGLGEHSGRY------AELAEALAAAGYAVLAFDLRGHGR 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  93 SRKHLYLETSskefwafsFDEMAKyDLPASIDFtVKQTRQEEIFYVGHSQGttiGFITFSTISKIAERIKiffALApVFS 172
Cdd:COG2267    69 SDGPRGHVDS--------FDDYVD-DLRAALDA-LRARPGLPVVLLGHSMG---GLIALLYAARYPDRVA---GLV-LLA 131
                         170
                  ....*....|....*
gi 2462517169 173 TKYLKSPLIRMTYKW 187
Cdd:COG2267   132 PAYRADPLLGPSARW 146
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
4-307 4.76e-45

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 158.88  E-value: 4.76e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169   4 SQIISYWGYPDEEYDIVTEDGYILGLYRIpywrTDNNKNLAQRV--VVYLQHGLLTSASSWISNLPNNSLGFILADAGYD 81
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRV----SSRNPRLGSQRgpPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFD 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  82 VWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFtVKQTRQEEIFYVGHSQGTTIGFITFsTISKIAERI 161
Cdd:PLN02872  110 VWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHY-VYSITNSKIFIVGHSQGTIMSLAAL-TQPNVVEMV 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169 162 KIFFALAPVFSTKYLKSPLI-RMTY-KWKSIVMAFSgnkdfLPKTSFKKFVGSKLcplqiFDKIC---LNILFMMFGYDP 236
Cdd:PLN02872  188 EAAALLCPISYLDHVTAPLVlRMVFmHLDQMVVAMG-----IHQLNFRSDVLVKL-----LDSICeghMDCNDLLTSITG 257
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517169 237 KN--LNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDlNLVHYNQTTSPLYNMTNMNVATAIW 307
Cdd:PLN02872  258 TNccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIFK-NLKLYGQVNPPAFDLSLIPKSLPLW 329
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
3-66 4.23e-24

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 93.37  E-value: 4.23e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517169   3 ISQIISYWGYPDEEYDIVTEDGYILGLYRIPYWRTdNNKNLAQRVVVYLQHGLLTSASSWISNL 66
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRN-NSNGKGGKPVVLLQHGLLASSDNWVTNG 63
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
48-277 5.41e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 70.61  E-value: 5.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  48 VVYLQHGLLTSASSWISNLPNnslgfiLADAGYDVWMGNSRGNTWSRKHLYLETsskefwaFSFDEMAKYdlpasIDFTV 127
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQDD-------YRTDDLAED-----LEYIL 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169 128 KQTRQEEIFYVGHSQGTTIGFITFstiSKIAERIKIFFALAPVfstkylkSPLIRMTYKWKSIVMAFSGNKDFLPKTSFK 207
Cdd:pfam00561  64 EALGLEKVNLVGHSMGGLIALAYA---AKYPDRVKALVLLGAL-------DPPHELDEADRFILALFPGFFDGFVADFAP 133
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169 208 KFVGSKLCPLQIFDKICLNILFMMfgyDPKNLNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDW 277
Cdd:pfam00561 134 NPLGRLVAKLLALLLLRLRLLKAL---PLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE 200
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-187 2.24e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 53.85  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  13 PDEEYDIVTEDGYilglyRIPYWRTDNNKNlAQRVVVYLqHGLLTSASSWisnlpnNSLGFILADAGYDVWMGNSRGNTW 92
Cdd:COG2267     2 TRRLVTLPTRDGL-----RLRGRRWRPAGS-PRGTVVLV-HGLGEHSGRY------AELAEALAAAGYAVLAFDLRGHGR 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  93 SRKHLYLETSskefwafsFDEMAKyDLPASIDFtVKQTRQEEIFYVGHSQGttiGFITFSTISKIAERIKiffALApVFS 172
Cdd:COG2267    69 SDGPRGHVDS--------FDDYVD-DLRAALDA-LRARPGLPVVLLGHSMG---GLIALLYAARYPDRVA---GLV-LLA 131
                         170
                  ....*....|....*
gi 2462517169 173 TKYLKSPLIRMTYKW 187
Cdd:COG2267   132 PAYRADPLLGPSARW 146
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
13-143 3.06e-03

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 39.10  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  13 PDEEYDIVTEDGYILGLYRipyWRTDNnknlAQRVVVYLQHGLLTSAS------SWisnlpnnslgfiLADAGYDVWMGN 86
Cdd:COG4757     6 SPESVTITAADGYPLAARL---FPPAG----PPRAVVLINPATGVPQRfyrpfaRY------------LAERGFAVLTYD 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517169  87 SRGNTWSRKhlyleTSSKEFwAFSFDEMAKYDLPASIDFTVKQTRQEEIFYVGHSQG 143
Cdd:COG4757    67 YRGIGLSRP-----GSLRGF-DAGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG 117
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
19-172 9.85e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 36.92  E-value: 9.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517169  19 IVTEDGYIL-GLYRIPywrtDNNKNLaqRVVVYLqHGllTSASSWISNLPNNSLgfiLADAGYDVWMGNSRGNTWSRKHL 97
Cdd:COG1506     2 FKSADGTTLpGWLYLP----ADGKKY--PVVVYV-HG--GPGSRDDSFLPLAQA---LASRGYAVLAPDYRGYGESAGDW 69
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517169  98 YLEtsskefwafsfdemAKYDLPASIDFTVKQTR--QEEIFYVGHSQGttiGFITFSTISKIAERIKIFFALAPVFS 172
Cdd:COG1506    70 GGD--------------EVDDVLAAIDYLAARPYvdPDRIGIYGHSYG---GYMALLAAARHPDRFKAAVALAGVSD 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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