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Conserved domains on  [gi|2462517411|ref|XP_054220970|]
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ciliary-associated calcium-binding coiled-coil protein 1 isoform X1 [Homo sapiens]

Protein Classification

CLAMP domain-containing protein( domain architecture ID 10632133)

CLAMP domain-containing protein similar to human ciliary-associated calcium-binding coiled-coil protein 1, a calcium-binding protein that may be involved in the control of sperm flagellar movement

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLAMP pfam14769
Flagellar C1a complex subunit C1a-32; This family represents one small subunit, C1a-32, of the ...
 35-134 2.94e-29

Flagellar C1a complex subunit C1a-32; This family represents one small subunit, C1a-32, of the C1a projection (the seventh projection of flagellar). Numerous studies have indicated that each of the seven projections associated with the central pair of microtubules in flagellar plays a distinct role in regulating eukaryotic ciliary/flagellar motility. The C1a projection is a complex of proteins including PF6, C1a-86, C1a-34, C1a-32, C1a-18, and calmodulin. C1a projection is involved in modulating flagellar beat frequency and this is mediated via the C1a-34, C1a-32, and C1a-18 sub-complex by modulating the activity of both the inner and outer dynein arms.


:

Pssm-ID: 464306  Cd Length: 99  Bit Score: 105.76  E-value: 2.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517411  35 SGFLWARGMDFSIIQYSKFMTLLAMSLQNLKTLHM-SLEESIKWLGEVMAEIGPTHSQKSEDwnIFDVKQANAIIDYLKI 113
Cdd:pfam14769   1 NTLLFAREQNFSVEQTSAFLSILKLLLENCISKPLgNIEDSFKYFKELLLCHSVHRPPFSIG--IFSLDQVKAIIDYFLN 78

                          90       100
                  ....*....|....*....|.
gi 2462517411 114 SLFQHYKLYEFMFYSAREEIV 134
Cdd:pfam14769  79 TYFRHYKLYKYVFTPQVELDL 99
 
Name Accession Description Interval E-value
CLAMP pfam14769
Flagellar C1a complex subunit C1a-32; This family represents one small subunit, C1a-32, of the ...
 35-134 2.94e-29

Flagellar C1a complex subunit C1a-32; This family represents one small subunit, C1a-32, of the C1a projection (the seventh projection of flagellar). Numerous studies have indicated that each of the seven projections associated with the central pair of microtubules in flagellar plays a distinct role in regulating eukaryotic ciliary/flagellar motility. The C1a projection is a complex of proteins including PF6, C1a-86, C1a-34, C1a-32, C1a-18, and calmodulin. C1a projection is involved in modulating flagellar beat frequency and this is mediated via the C1a-34, C1a-32, and C1a-18 sub-complex by modulating the activity of both the inner and outer dynein arms.


Pssm-ID: 464306  Cd Length: 99  Bit Score: 105.76  E-value: 2.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517411  35 SGFLWARGMDFSIIQYSKFMTLLAMSLQNLKTLHM-SLEESIKWLGEVMAEIGPTHSQKSEDwnIFDVKQANAIIDYLKI 113
Cdd:pfam14769   1 NTLLFAREQNFSVEQTSAFLSILKLLLENCISKPLgNIEDSFKYFKELLLCHSVHRPPFSIG--IFSLDQVKAIIDYFLN 78

                          90       100
                  ....*....|....*....|.
gi 2462517411 114 SLFQHYKLYEFMFYSAREEIV 134
Cdd:pfam14769  79 TYFRHYKLYKYVFTPQVELDL 99
 
Name Accession Description Interval E-value
CLAMP pfam14769
Flagellar C1a complex subunit C1a-32; This family represents one small subunit, C1a-32, of the ...
 35-134 2.94e-29

Flagellar C1a complex subunit C1a-32; This family represents one small subunit, C1a-32, of the C1a projection (the seventh projection of flagellar). Numerous studies have indicated that each of the seven projections associated with the central pair of microtubules in flagellar plays a distinct role in regulating eukaryotic ciliary/flagellar motility. The C1a projection is a complex of proteins including PF6, C1a-86, C1a-34, C1a-32, C1a-18, and calmodulin. C1a projection is involved in modulating flagellar beat frequency and this is mediated via the C1a-34, C1a-32, and C1a-18 sub-complex by modulating the activity of both the inner and outer dynein arms.


Pssm-ID: 464306  Cd Length: 99  Bit Score: 105.76  E-value: 2.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517411  35 SGFLWARGMDFSIIQYSKFMTLLAMSLQNLKTLHM-SLEESIKWLGEVMAEIGPTHSQKSEDwnIFDVKQANAIIDYLKI 113
Cdd:pfam14769   1 NTLLFAREQNFSVEQTSAFLSILKLLLENCISKPLgNIEDSFKYFKELLLCHSVHRPPFSIG--IFSLDQVKAIIDYFLN 78

                          90       100
                  ....*....|....*....|.
gi 2462517411 114 SLFQHYKLYEFMFYSAREEIV 134
Cdd:pfam14769  79 TYFRHYKLYKYVFTPQVELDL 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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