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Conserved domains on  [gi|2462517859|ref|XP_054221190|]
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ankyrin repeat domain-containing protein 26 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 914-1217 8.24e-162

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 492.96  E-value: 8.24e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  914 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 993
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  994 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1073
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1074 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1153
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517859 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1217
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1523-1631 1.23e-56

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 191.42  E-value: 1.23e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1523 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1602
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517859 1603 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1631
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 2.68e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 2.68e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517859  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 747-1414 1.25e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 92.81  E-value: 1.25e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  747 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 812
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  813 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQDGILTNHLSKQK 887
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRERLQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKC------FEDLKIVKEKNEDLQKTIK 961
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVK 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  962 QNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------DQ 1022
Cdd:TIGR02168  510 ALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQG 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1023 SETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL----R 1088
Cdd:TIGR02168  589 NDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggsA 666

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1089 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1168
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1169 DQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRY 1248
Cdd:TIGR02168  747 ER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1249 RiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK----------- 1317
Cdd:TIGR02168  813 T-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleealal 891

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1318 -NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEMD 1396
Cdd:TIGR02168  892 lRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKIE 964

                          730
                   ....*....|....*...
gi 2462517859 1397 IQINKLKHKIDDLTAELE 1414
Cdd:TIGR02168  965 DDEEEARRRLKRLENKIK 982
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1394-1567 1.02e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1394 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1473
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1474 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1542
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2462517859 1543 SQEDFNKTELEKYKQLYlEELKVRK 1567
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 914-1217 8.24e-162

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 492.96  E-value: 8.24e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  914 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 993
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  994 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1073
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1074 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1153
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517859 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1217
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1523-1631 1.23e-56

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 191.42  E-value: 1.23e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1523 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1602
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517859 1603 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1631
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 2.68e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 2.68e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517859  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 4.40e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 4.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462517859  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 747-1414 1.25e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 92.81  E-value: 1.25e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  747 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 812
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  813 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQDGILTNHLSKQK 887
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRERLQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKC------FEDLKIVKEKNEDLQKTIK 961
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVK 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  962 QNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------DQ 1022
Cdd:TIGR02168  510 ALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQG 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1023 SETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL----R 1088
Cdd:TIGR02168  589 NDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggsA 666

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1089 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1168
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1169 DQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRY 1248
Cdd:TIGR02168  747 ER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1249 RiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK----------- 1317
Cdd:TIGR02168  813 T-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleealal 891

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1318 -NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEMD 1396
Cdd:TIGR02168  892 lRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKIE 964

                          730
                   ....*....|....*...
gi 2462517859 1397 IQINKLKHKIDDLTAELE 1414
Cdd:TIGR02168  965 DDEEEARRRLKRLENKIK 982
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.37e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.56  E-value: 1.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859    9 GESPLgSFARRRRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517859  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 753-1534 2.93e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.07  E-value: 2.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  753 IKKMEDKVNVLQRELSETKEIKsqlEHQKVEWERELCSLRFSLnQEEEKRRNAdtlyekiREQLRRKEEQYRKEVevKQQ 832
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKL-QEMQMERDA-------MADIRRRESQSQEDL--RNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  833 LELSLQTLEMElRTVKSNLnqvvqeRNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHEEEKDL- 910
Cdd:pfam15921  147 LQNTVHELEAA-KCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLg 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  911 SHKNSMLQE---EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED-LQKTIKQNE---ETLTQTISQYNGRLSVLTA 983
Cdd:pfam15921  220 SAISKILREldtEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDrIEQLISEHEveiTGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  984 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-----RDQSETSKRELELA---FQRARDEcsrlQDKMNFDVSNL 1055
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE----RDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1056 KDNNEILSQQLFKTESKLnSLE---------------IEFHHTRDALREKTLGLERVQKDLS--QTQCQmKEMEQKYQNE 1118
Cdd:pfam15921  376 DDQLQKLLADLHKREKEL-SLEkeqnkrlwdrdtgnsITIDHLRRELDDRNMEVQRLEALLKamKSECQ-GQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1119 QvkvnkyiGKQESVEERLS---QLQSENMLLRQQLDDAHNKA---DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1192
Cdd:pfam15921  454 Q-------GKNESLEKVSSltaQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1193 NKELiSECNHLKERQYQYENEKAErevvvrqlqqelADTLKKQsMSEASlEVTSRYRINLEDETQdLKKKLGQIRNQLQe 1272
Cdd:pfam15921  527 DLKL-QELQHLKNEGDHLRNVQTE------------CEALKLQ-MAEKD-KVIEILRQQIENMTQ-LVGQHGRTAGAMQ- 589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1273 aqdrhTEAVRCAEKMQDHKQKLEKdnakLKVTVKKQMDKIEELQknllnANLSEDEKEQLKKLMELKQSLECnldqemKK 1352
Cdd:pfam15921  590 -----VEKAQLEKEINDRRLELQE----FKILKDKKDAKIRELE-----ARVSDLELEKVKLVNAGSERLRA------VK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1353 NVELEREitGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS-------------- 1418
Cdd:pfam15921  650 DIKQERD--QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNtlksmegsdghamk 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1419 --------------KCLHLDTKNQILQEellSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1484
Cdd:pfam15921  728 vamgmqkqitakrgQIDALQSKIQFLEE---AMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462517859 1485 R-ARQEIAekLKEVNLflqaQAASQENLEQFRENNFASMKSQMELRIKDLE 1534
Cdd:pfam15921  805 KvANMEVA--LDKASL----QFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1149-1587 9.93e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.09  E-value: 9.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1149 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1219
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1220 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1296
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1297 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1372
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1373 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1443
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1444 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1511
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1512 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1571
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 2462517859 1572 KLTKTNERLAEVNTKL 1587
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 725-1272 3.90e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.42  E-value: 3.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  725 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 801
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  802 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 874
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  875 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 954
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  955 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1034
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1035 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1114
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1115 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1188
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1189 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1268
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2462517859 1269 QLQE 1272
Cdd:COG1196    775 EIEA 778
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1070-1378 4.14e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.96  E-value: 4.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1070 ESKLNSLEIEfhhTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQ 1149
Cdd:COG1196    199 ERQLEPLERQ---AEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1150 LDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELA 1229
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRR-ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1230 DTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQM 1309
Cdd:COG1196    355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1310 DKIEELQKNLLNANLSEDEKEQ-LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYE 1378
Cdd:COG1196    435 EEEEEEEEALEEAAEEEAELEEeEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 741-1177 9.61e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.50  E-value: 9.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  741 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 820
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  821 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 879
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  880 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 957
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  958 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1034
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1035 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1102
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517859 1103 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1177
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
800-1368 9.49e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.46  E-value: 9.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  800 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 878
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  879 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 953
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  954 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1015
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1016 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1092
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1093 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1151
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1152 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1228
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1229 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1308
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1309 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1368
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 6.16e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 6.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517859  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.29e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.08  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517859  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1394-1567 1.02e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1394 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1473
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1474 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1542
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2462517859 1543 SQEDFNKTELEKYKQLYlEELKVRK 1567
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1398-1558 4.30e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.20  E-value: 4.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1398 QINKLKHKIDDLTAELEtagSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIErnmvelgqvKQ 1477
Cdd:PRK00409   510 LIGEDKEKLNELIASLE---ELERELEQKAEEAEALL---KEAEKLKEELEEKKEKLQEEEDKLLEEAE---------KE 574

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1478 YKQEIEErARQEIAEKLKEVNLFLQAQAASQenleqfRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQ 1557
Cdd:PRK00409   575 AQQAIKE-AKKEADEIIKELRQLQKGGYASV------KAHELIEARKRLNKANEKKEKKKKKQKEKQEELKVGDEVKYLS 647


                   .
gi 2462517859 1558 L 1558
Cdd:PRK00409   648 L 648
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.63e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517859    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1260-1592 2.62e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 42.53  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1260 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1325
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1326 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1393
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1394 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1459
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1460 NLRSHIER-------NMVELGQVKQYKQEIEerarqEIAEKLKEVnlflqaqaasqenLEQFRENNFASmkSQMELRIKD 1532
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLE-----ELEKRYDEI-------------VERLEEKEVAY--SELQEELEE 368

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1533 LESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1592
Cdd:pfam06160  369 ILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
 914-1217 8.24e-162

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 492.96  E-value: 8.24e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  914 NSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLE 993
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  994 NEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKL 1073
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1074 NSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDA 1153
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517859 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAER 1217
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 1523-1631 1.23e-56

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 191.42  E-value: 1.23e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1523 KSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLT 1602
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90       100
                   ....*....|....*....|....*....
gi 2462517859 1603 TRPVMEPPCVGNLNNSLDLNRKLIPRENL 1631
Cdd:pfam12001   81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 2.68e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 2.68e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666    131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210


                   ....*..
gi 2462517859  204 NVNAVDK 210
Cdd:COG0666    211 DVNAKDN 217
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-218 2.53e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 140.09  E-value: 2.53e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCA 129
Cdd:COG0666     91 LHAAARNGDLEIVKL-LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:COG0666    170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249


                   ....*....
gi 2462517859  210 KLESSHQLI 218
Cdd:COG0666    250 KDGLTALLL 258
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-210 4.40e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.98  E-value: 4.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEK 127
Cdd:COG0666    124 LHLAAYNGNLEIVK---LLLEAGadVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  128 CATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:COG0666    201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAA 280


                   ...
gi 2462517859  208 VDK 210
Cdd:COG0666    281 ALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-210 1.91e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.28  E-value: 1.91e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   44 DRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQC 123
Cdd:COG0666     18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  124 QEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:COG0666     98 GDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177


                   ....*..
gi 2462517859  204 NVNAVDK 210
Cdd:COG0666    178 DVNARDN 184
Ank_2 pfam12796
Ankyrin repeats (3 copies);
84-176 4.40e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 4.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   84 LHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHgADPNLADvHGNTALHYAVYNEDISVAT 163
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 2462517859  164 KLLLYDANIEAKN 176
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
50-143 1.65e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 84.78  E-value: 1.65e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDrKCQLNVCDNeNRTALMKAVQCQEEKCA 129
Cdd:pfam12796    1 LHLAAKNGNLELVKL-LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 2462517859  130 TILLEHGADPNLAD 143
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-183 1.15e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.47  E-value: 1.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNVAKVQqiLLLRKNG-LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKC 128
Cdd:COG0666    157 LHLAAANGNLEIVK--LLLEAGAdVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEI 234

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462517859  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPL 183
Cdd:COG0666    235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 747-1414 1.25e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 92.81  E-value: 1.25e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  747 ELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSL-----------NQEEEKRRNADTLYEKI--- 812
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLeeleaqleeleSKLDELAEELAELEEKLeel 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  813 REQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-----EQNARMLQDGILTNHLSKQK 887
Cdd:TIGR02168  350 KEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlERLEDRRERLQQEIEELLKK 429

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  888 EIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKC------FEDLKIVKEKNEDLQKTIK 961
Cdd:TIGR02168  430 LEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELaqlqarLDSLERLQENLEGFSEGVK 509

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  962 QNEETLTQtISQYNGRLSVL--------TAENAMLNSKL-----ENEKQSKERLEAEVESYHSRLAAAIHDR------DQ 1022
Cdd:TIGR02168  510 ALLKNQSG-LSGILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVTFLPLDSikgteiQG 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1023 SETSKRELELAFQRARDEC----SRLQDKMNF------DVSNLKDNNEILSQQLFktESKLNSLEIEFHHTRDAL----R 1088
Cdd:TIGR02168  589 NDREILKNIEGFLGVAKDLvkfdPKLRKALSYllggvlVVDDLDNALELAKKLRP--GYRIVTLDGDLVRPGGVItggsA 666

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1089 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQ 1168
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1169 DQfhaiVQKLQAESEKQSLLLEERNKELISECNHLKERqyqyENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRY 1248
Cdd:TIGR02168  747 ER----IAQLSKELTELEAEIEELEERLEEAEEELAEA----EAEIEELEAQIEQLKEEL------KALREALDELRAEL 812

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1249 RiNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQK----------- 1317
Cdd:TIGR02168  813 T-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNerasleealal 891

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1318 -NLLNANLSEDEKEQLKKLMELKQslecNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFsfhGDLKTSQFEMD 1396
Cdd:TIGR02168  892 lRSELEELSEELRELESKRSELRR----ELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL---EEAEALENKIE 964

                          730
                   ....*....|....*...
gi 2462517859 1397 IQINKLKHKIDDLTAELE 1414
Cdd:TIGR02168  965 DDEEEARRRLKRLENKIK 982
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 740-1558 3.92e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 91.27  E-value: 3.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  740 ELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRK 819
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  820 EEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLsreqnarmlqDGILTNHLSKQKEIEMAQKKMnsE 899
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL----------EELKEELESLEAELEELEAEL--E 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  900 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQKTIKQNEETLTqtisqyNGRLS 979
Cdd:TIGR02168  369 ELESRLEELEEQLET--LRSKVAQLELQIASLNNEIERLEAR----LERLEDRRERLQQEIEELLKKLE------EAELK 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  980 VLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQsetSKRELELAFQRARDECSRLQDKMNF--DVSNLKD 1057
Cdd:TIGR02168  437 ELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDA---AERELAQLQARLDSLERLQENLEGFseGVKALLK 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1058 NNEILSQ------QLFKTESKLnsleiefhhtRDALrEKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN----KYI 1126
Cdd:TIGR02168  514 NQSGLSGilgvlsELISVDEGY----------EAAI-EAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflplDSI 581

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1127 GKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNkeLISECNHLKER 1206
Cdd:TIGR02168  582 KGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYR--IVTLDGDLVRP 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1207 QYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEK 1286
Cdd:TIGR02168  658 GGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLAR 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1287 MQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNL 1366
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTELEAEIEELEERL------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE 811

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1367 LKMTRKKLNEYENGEFSF---HGDLKTSQFEMDIQINKLKHKIDDLTAELETAgskclhldtknQILQEELlsmktvQKK 1443
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLerrIAATERRLEDLEEQIEELSEDIESLAAEIEEL-----------EELIEEL------ESE 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1444 CEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIeERARQEIAEKLKEVNLFLQ-AQAASQENLEQFREN----- 1517
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSEL-RRELEELREKLAQLELRLEgLEVRIDNLQERLSEEysltl 953

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 2462517859 1518 -NFASMKSQMELRIKDLESELSKIKTSQEDF---NKTELEKYKQL 1558
Cdd:TIGR02168  954 eEAEALENKIEDDEEEARRRLKRLENKIKELgpvNLAAIEEYEEL 998
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-210 2.92e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.24  E-value: 2.92e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   65 ILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADV 144
Cdd:COG0666      6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517859  145 HGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:COG0666     86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 753-1559 6.68e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.42  E-value: 6.68e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  753 IKKMEDKVNVLQRELSET---KEIKSQLEhqkvEWERELCSLRFslNQEEEKRrnadtlyEKIREQLRRKEEQYRKEVEV 829
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAeryKELKAELR----ELELALLVLRL--EELREEL-------EELQEELKEAEEELEELTAE 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  830 KQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGiLTNHLSKQKEIEMAQKKMNSENSHSHEEEK 908
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRlEQQKQILRER-LANLERQLEELEAQLEELESKLDELAEELA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  909 DLSHKNSMLQEEIAMLRLEIDTIKNQNQE---KEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ---TISQYNGRLSVLT 982
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEElesRLEELEEQLETLRSKVAQLELQIASLNNEIERleaRLERLEDRRERLQ 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  983 AENAMLNSKLENEKQSK-----ERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFdVSNLKD 1057
Cdd:TIGR02168  421 QEIEELLKKLEEAELKElqaelEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS-LERLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1058 NNEILSQ---QLFKTESKLNSLE------IEFHHTRDALREKTLGlERVQKDLSQT-QCQMKEMEQKYQNEQVKVN---- 1123
Cdd:TIGR02168  500 NLEGFSEgvkALLKNQSGLSGILgvlselISVDEGYEAAIEAALG-GRLQAVVVENlNAAKKAIAFLKQNELGRVTflpl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1124 KYIGKQESVEERLSQLQSENMLLRQQLDdaHNKADNKEKTVINIQDQFHAIVQKLQ------------------------ 1179
Cdd:TIGR02168  579 DSIKGTEIQGNDREILKNIEGFLGVAKD--LVKFDPKLRKALSYLLGGVLVVDDLDnalelakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1180 --------AESEKQSLL--------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1243
Cdd:TIGR02168  657 pggvitggSAKTNSSILerrreieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLA 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1244 VTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnan 1323
Cdd:TIGR02168  737 RLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL---- 812

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1324 lsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMD---IQIN 1400
Cdd:TIGR02168  813 --TLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAsleEALA 890

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1401 KLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCE-KLQKNKKKL-EQEVINLRSHIERNMVELGQVKQY 1478
Cdd:TIGR02168  891 LLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvRIDNLQERLsEEYSLTLEEAEALENKIEDDEEEA 970

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1479 KQEIeERARQEIAEkLKEVNLflqaqaasqENLEQFRENN--FASMKSQMElrikDLESELSKIKTSQEDFNKTELEKYK 1556
Cdd:TIGR02168  971 RRRL-KRLENKIKE-LGPVNL---------AAIEEYEELKerYDFLTAQKE----DLTEAKETLEEAIEEIDREARERFK 1035


                   ...
gi 2462517859 1557 QLY 1559
Cdd:TIGR02168 1036 DTF 1038
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 736-1498 8.18e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 77.03  E-value: 8.18e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  736 ERLLELKKNHCELLTVKIKKMEDKVNVLQRELSE-TKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIRE 814
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  815 QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL-SREQNARMLQDgiltNHLSKQKEIEMAQ 893
Cdd:TIGR02169  323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELeEVDKEFAETRD----ELKDYREKLEKLK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  894 KKMNSenshsheeekdLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLQKTIKQNEETLTQTISQ 973
Cdd:TIGR02169  399 REINE-----------LKRELDRLQEELQRLSEELADLNAAIAGIE----AKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  974 yngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLaaaihdrdqsetSKRELELAFQRARDECSRLQDKMNFDVS 1053
Cdd:TIGR02169  464 ------------------LSKYEQELYDLKEEYDRVEKEL------------SKLQRELAEAEAQARASEERVRGGRAVE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1054 NLKDNNeilSQQLFKTESKLNSLE-----------------------------IEFHHTRDALREKTLGLERVQKDLSQT 1104
Cdd:TIGR02169  514 EVLKAS---IQGVHGTVAQLGSVGeryataievaagnrlnnvvveddavakeaIELLKRRKAGRATFLPLNKMRDERRDL 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1105 QCQMK-----------EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENML-LRQQLDD---AHNKADNKEKTVINIQD 1169
Cdd:TIGR02169  591 SILSEdgvigfavdlvEFDPKYEPAFKYVFGDTLVVEDIEAARRLMGKYRMVtLEGELFEksgAMTGGSRAPRGGILFSR 670

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1170 QFHAIVQKLQAESEKqsllLEERNKELISECNHLKER--QYQYENEKAEREVVVRQ-----LQQELADTLKKQSMSEASL 1242
Cdd:TIGR02169  671 SEPAELQRLRERLEG----LKRELSSLQSELRRIENRldELSQELSDASRKIGEIEkeieqLEQEEEKLKERLEELEEDL 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1243 EVTSRYRINLEDETQDLKKKLGQIRNQLQEAQdrhtEAVRCAEKMQDHK--QKLEKDNAKLKVTVKKQMDKIEELQKNLl 1320
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELEEDLHKLE----EALNDLEARLSHSriPEIQAELSKLEEEVSRIEARLREIEQKL- 821

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1321 naNLSEDEKEQLKKLMELKQS----LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYEngefSFHGDLKTSQFEMD 1396
Cdd:TIGR02169  822 --NRLTLEKEYLEKEIQELQEqridLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLE----SRLGDLKKERDELE 895

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1397 IQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-----------------LSMKTVQKKCEKLQKNKKKLEQevI 1459
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELseiedpkgedeeipeeeLSLEDVQAELQRVEEEIRALEP--V 973

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|
gi 2462517859 1460 NLRSHIERNMVELGQVK-QYKQEIEERARQEIAEKLKEVN 1498
Cdd:TIGR02169  974 NMLAIQEYEEVLKRLDElKEKRAKLEEERKAILERIEEYE 1013
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-220 1.37e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.56  E-value: 1.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859    9 GESPLgSFARRRRSSAGGGGEPGEGAYsqPGYHVRDRDlGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLAC 88
Cdd:PHA02875    35 GISPI-KLAMKFRDSEAIKLLMKHGAI--PDVKYPDIE-SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLAT 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   89 ANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY 168
Cdd:PHA02875   111 ILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517859  169 DANIEAKNKD-DLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISE 220
Cdd:PHA02875   191 GANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEECTILD 243
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 753-1534 2.93e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.07  E-value: 2.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  753 IKKMEDKVNVLQRELSETKEIKsqlEHQKVEWERELCSLRFSLnQEEEKRRNAdtlyekiREQLRRKEEQYRKEVevKQQ 832
Cdd:pfam15921   80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKL-QEMQMERDA-------MADIRRRESQSQEDL--RNQ 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  833 LELSLQTLEMElRTVKSNLnqvvqeRNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQ-KKMNSENSHSHEEEKDL- 910
Cdd:pfam15921  147 LQNTVHELEAA-KCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASgKKIYEHDSMSTMHFRSLg 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  911 SHKNSMLQE---EIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNED-LQKTIKQNE---ETLTQTISQYNGRLSVLTA 983
Cdd:pfam15921  220 SAISKILREldtEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDrIEQLISEHEveiTGLTEKASSARSQANSIQS 299

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  984 ENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-----RDQSETSKRELELA---FQRARDEcsrlQDKMNFDVSNL 1055
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE----RDQFSQESGNL 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1056 KDNNEILSQQLFKTESKLnSLE---------------IEFHHTRDALREKTLGLERVQKDLS--QTQCQmKEMEQKYQNE 1118
Cdd:pfam15921  376 DDQLQKLLADLHKREKEL-SLEkeqnkrlwdrdtgnsITIDHLRRELDDRNMEVQRLEALLKamKSECQ-GQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1119 QvkvnkyiGKQESVEERLS---QLQSENMLLRQQLDDAHNKA---DNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEER 1192
Cdd:pfam15921  454 Q-------GKNESLEKVSSltaQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1193 NKELiSECNHLKERQYQYENEKAErevvvrqlqqelADTLKKQsMSEASlEVTSRYRINLEDETQdLKKKLGQIRNQLQe 1272
Cdd:pfam15921  527 DLKL-QELQHLKNEGDHLRNVQTE------------CEALKLQ-MAEKD-KVIEILRQQIENMTQ-LVGQHGRTAGAMQ- 589

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1273 aqdrhTEAVRCAEKMQDHKQKLEKdnakLKVTVKKQMDKIEELQknllnANLSEDEKEQLKKLMELKQSLECnldqemKK 1352
Cdd:pfam15921  590 -----VEKAQLEKEINDRRLELQE----FKILKDKKDAKIRELE-----ARVSDLELEKVKLVNAGSERLRA------VK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1353 NVELEREitGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS-------------- 1418
Cdd:pfam15921  650 DIKQERD--QLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNtlksmegsdghamk 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1419 --------------KCLHLDTKNQILQEellSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE 1484
Cdd:pfam15921  728 vamgmqkqitakrgQIDALQSKIQFLEE---AMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462517859 1485 R-ARQEIAekLKEVNLflqaQAASQENLEQFRENNFASMKSQMELRIKDLE 1534
Cdd:pfam15921  805 KvANMEVA--LDKASL----QFAECQDIIQRQEQESVRLKLQHTLDVKELQ 849
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 725-1275 3.80e-12

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 71.74  E-value: 3.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  725 LLKIQDAALSCERLL-ELKKNHCELLTVKiKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRR 803
Cdd:pfam01576   14 LQKVKERQQKAESELkELEKKHQQLCEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESRLEEEEERSQ 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  804 NADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvqerNDAQRQLSREQNARMLQDGILTNHL 883
Cdd:pfam01576   93 QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLL----EDQNSKLSKERKLLEERISEFTSNL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  884 SKQKE---------------IEMAQKKMNSENSHSHEEEK---DLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfed 945
Cdd:pfam01576  169 AEEEEkakslsklknkheamISDLEERLKKEEKGRQELEKakrKLEGESTDLQEQIAELQAQIAELRAQLAKKE------ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  946 lkivkeknEDLQKTIKQNEETLTQTiSQYNGRLSVLTAENAMLNSKLENEKQSKER-------LEAEVESYHSRLAAAIH 1018
Cdd:pfam01576  243 --------EELQAALARLEEETAQK-NNALKKIRELEAQISELQEDLESERAARNKaekqrrdLGEELEALKTELEDTLD 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1019 DR--DQSETSKRELELA-FQRARDECSRLQDKMNFDVSNLKDNN-EILSQQLFKTESKLNSLEiefhHTRDALREKTLGL 1094
Cdd:pfam01576  314 TTaaQQELRSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKRNKANLE----KAKQALESENAEL 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1095 ERVQKDLSQ----TQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQ 1170
Cdd:pfam01576  390 QAELRTLQQakqdSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1171 FHAiVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ----SMSEASLEVTS 1246
Cdd:pfam01576  470 LQD-TQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLeedaGTLEALEEGKK 548

                          570       580       590
                   ....*....|....*....|....*....|....*
gi 2462517859 1247 RYRINLEDETQDLKKK------LGQIRNQLQEAQD 1275
Cdd:pfam01576  549 RLQRELEALTQQLEEKaaaydkLEKTKNRLQQELD 583
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 54-210 7.93e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 7.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   54 ASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACAN--GHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI 131
Cdd:PHA03100    80 YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKIL 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  132 ------------------LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA03100   160 kllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKE 239

                          170
                   ....*....|....*..
gi 2462517859  194 MVEFLIKKKANVNAVDK 210
Cdd:PHA03100   240 IFKLLLNNGPSIKTIIE 256
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1149-1587 9.93e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.09  E-value: 9.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1149 QLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLL--LEERNKELISECNHL--KERQYQYENEKAEREV----- 1219
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIkeKEKELEEVLREINEIssELPELREELEKLEKEVkelee 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1220 ---VVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIrNQLQEAQDRHTEAVRCAEKMQDHKQKLEK 1296
Cdd:PRK03918   236 lkeEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL-KELKEKAEEYIKLSEFYEEYLDELREIEK 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1297 DNAKLKV---TVKKQMDKIEELQKNLlnANLSEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNL-LKMTRK 1372
Cdd:PRK03918   315 RLSRLEEeinGIEERIKELEEKEERL--EELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLKKRLTGLtPEKLEK 391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1373 KLNEYENGEFSFHGDLKtsqfEMDIQINKLKHKIDDLTA---ELETAGSKC------LHLDTKNQILQEELLSMKTVQKK 1443
Cdd:PRK03918   392 ELEELEKAKEEIEEEIS----KITARIGELKKEIKELKKaieELKKAKGKCpvcgreLTEEHRKELLEEYTAELKRIEKE 467

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1444 CEKLQKNKKKLEQEVINLRSHI--ERNMVELGQVKQYKQEIEER----------ARQEIAEKLKEVNLFLQAQAASQENl 1511
Cdd:PRK03918   468 LKEIEEKERKLRKELRELEKVLkkESELIKLKELAEQLKELEEKlkkynleeleKKAEEYEKLKEKLIKLKGEIKSLKK- 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1512 EQFRENNFASMKSQMELRIKDLESELSKIKT--------SQEDFNKT--ELEKYKQLYLE----------ELKVRKSLSS 1571
Cdd:PRK03918   547 ELEKLEELKKKLAELEKKLDELEEELAELLKeleelgfeSVEELEERlkELEPFYNEYLElkdaekelerEEKELKKLEE 626

                          490
                   ....*....|....*.
gi 2462517859 1572 KLTKTNERLAEVNTKL 1587
Cdd:PRK03918   627 ELDKAFEELAETEKRL 642
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 927-1587 1.40e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.66  E-value: 1.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  927 EIDTIKNQ--NQEKEKKCFEDLKIVKEKN----EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1000
Cdd:TIGR04523   41 KLKTIKNElkNKEKELKNLDKNLNKDEEKinnsNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1001 RLEAEVESyhsrlaaaihdrdqsetSKRELElafqrardECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEF 1080
Cdd:TIGR04523  121 KLEVELNK-----------------LEKQKK--------ENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENEL 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1081 HHTRDALREKtlglervQKDLSQTQCQMKEMEQKYQNEQvkvnKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1160
Cdd:TIGR04523  176 NLLEKEKLNI-------QKNIDKIKNKLLKLELLLSNLK----KKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEK 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1161 EKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKkqsmsea 1240
Cdd:TIGR04523  245 TTEISNTQTQLNQLKDEQNKIKKQ----LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELK------- 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1241 slevtsryrinleDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNll 1320
Cdd:TIGR04523  314 -------------SELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKE-- 378

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1321 nanlSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGF---KNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1397
Cdd:TIGR04523  379 ----NQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLqqeKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEL 454

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1398 QINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQ 1477
Cdd:TIGR04523  455 IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKEL---KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES 531

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1478 YKQEIEERARQ------EIAEKLKEVNLFLQAQaASQENLEQFRENNFASMKSQMEL--RIKDLESELSKIKTSQEDFNK 1549
Cdd:TIGR04523  532 EKKEKESKISDledelnKDDFELKKENLEKEID-EKNKEIEELKQTQKSLKKKQEEKqeLIDQKEKEKKDLIKEIEEKEK 610

                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 2462517859 1550 TELEKYKQLYLEELKVRKsLSSKLTKTNERLAEVNTKL 1587
Cdd:TIGR04523  611 KISSLEKELEKAKKENEK-LSSIIKNIKSKKNKLKQEV 647
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-212 2.04e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   94 EVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATI---LLEHGADPNLADVHGNTALHYAVYNED-ISVATKLLLYD 169
Cdd:PHA03095    28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAG 107

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2462517859  170 ANIEAKNKDDLTPLLLAVSGK--KQQMVEFLIKKKANVNAVDKLE 212
Cdd:PHA03095   108 ADVNAKDKVGRTPLHVYLSGFniNPKVIRLLLRKGADVNALDLYG 152
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 763-1457 2.75e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 68.84  E-value: 2.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  763 LQRELSETKEIKSQLEhqKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLrrKEEQYRKEVEVKQQLELSLQTLEM 842
Cdd:TIGR00618  158 LKAKSKEKKELLMNLF--PLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC--TPCMPDTYHERKQVLEKELKHLRE 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  843 ELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGI------LTNHLSKQKEIEMA------------------------ 892
Cdd:TIGR00618  234 ALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIeelraqEAVLEETQERINRArkaaplaahikavtqieqqaqrih 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  893 ---QKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQ 969
Cdd:TIGR00618  314 telQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  970 TISQYNGRLSVLTAENAM---LNSKLENEKQSKERLEAEVE---SYHSRLAAAIHDRDQSET-SKRELELAFQRARDECS 1042
Cdd:TIGR00618  394 KLQSLCKELDILQREQATidtRTSAFRDLQGQLAHAKKQQElqqRYAELCAAAITCTAQCEKlEKIHLQESAQSLKEREQ 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1043 RLQDKMNF--DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREktlglervqkdLSQTQCQMKEMEQKYQNEQV 1120
Cdd:TIGR00618  474 QLQTKEQIhlQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDN-----------PGPLTRRMQRGEQTYAQLET 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1121 KVNKYIGKQESVEERLSQLQSENMLLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKL---QAESEKQSLLLEERNKELI 1197
Cdd:TIGR00618  543 SEEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQCDNRSKEDIPNLQNITVRLQDLtekLSEAEDMLACEQHALLRKL 621

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1198 SECNHlKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTS------RYRINLEDETQDLKKKLGQIRNQLQ 1271
Cdd:TIGR00618  622 QPEQD-LQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVlpkellASRQLALQKMQSEKEQLTYWKEMLA 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1272 EAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLnanlsEDEKEQLKKLMELKQslecnldqemK 1351
Cdd:TIGR00618  701 QCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELM-----HQARTVLKARTEAHF----------N 765

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1352 KNVELEREITGFKNLLKMTRKKLNEYENGEFSFHgdlKTSQFEMDIQiNKLKHKIDDLTAELETAGSKCLHLDTKNQILQ 1431
Cdd:TIGR00618  766 NNEEVTAALQTGAELSHLAAEIQFFNRLREEDTH---LLKTLEAEIG-QEIPSDEDILNLQCETLVQEEEQFLSRLEEKS 841

                          730       740
                   ....*....|....*....|....*.
gi 2462517859 1432 EELLSMKTVQKKCEKLQKNKKKLEQE 1457
Cdd:TIGR00618  842 ATLGEITHQLLKYEECSKQLAQLTQE 867
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 725-1272 3.90e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.42  E-value: 3.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  725 LLKIQDAALSCERL---LELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEK 801
Cdd:COG1196    231 LLKLRELEAELEELeaeLEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  802 RRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQV-------VQERNDAQRQLSREQNARML 874
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAeealleaEAELAEAEEELEELAEELLE 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  875 QDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNE 954
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE----EEEEALLELLA 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  955 DLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAf 1034
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA- 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1035 qrardecSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLSQTQCQMKEMEQK 1114
Cdd:COG1196    546 -------AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVASDLREADAR 614

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1115 Y---QNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQS---LL 1188
Cdd:COG1196    615 YyvlGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAeeeLE 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1189 LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRN 1268
Cdd:COG1196    695 LEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLER 774


                   ....
gi 2462517859 1269 QLQE 1272
Cdd:COG1196    775 EIEA 778
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 814-1575 5.45e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.79  E-value: 5.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  814 EQLRRKEEQYRKEVEvkqQLELSLQTLEMELRTVKSNLNQVVQERNDAQR--QLSREqnarmLQDGILTNHLsKQKEIEM 891
Cdd:TIGR02169  166 AEFDRKKEKALEELE---EVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKE-----KREYEGYELL-KEKEALE 236

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  892 AQKKmnsenshshEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 971
Cdd:TIGR02169  237 RQKE---------AIERQLAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEI 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  972 SQ-------YNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI----HDRDQSETSKRELE---LAFQRA 1037
Cdd:TIGR02169  304 ASlersiaeKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTeeyaELKEELEDLRAELEevdKEFAET 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1038 RDECSRLQDKM----------NFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQ 1107
Cdd:TIGR02169  384 RDELKDYREKLeklkreinelKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1108 MKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHN-----KADN-------------KEKTVINIQ- 1168
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAveevlKASIqgvhgtvaqlgsvGERYATAIEv 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1169 ---DQFHAIVQKLQAESEKQSLLLEERN------------------KELISECNHLK--------ERQYQ---------- 1209
Cdd:TIGR02169  544 aagNRLNNVVVEDDAVAKEAIELLKRRKagratflplnkmrderrdLSILSEDGVIGfavdlvefDPKYEpafkyvfgdt 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1210 --YENEKAEREVVVR----QLQQELADtlKKQSMS----------------EASLEVTSRYRINLEDETQDLKKKLGQIR 1267
Cdd:TIGR02169  624 lvVEDIEAARRLMGKyrmvTLEGELFE--KSGAMTggsraprggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIE 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1268 NQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLECNLD 1347
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI------ENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1348 QEMKKNVELEREITGFKnllkmTRKKLNEYEngefsfhgDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHL---- 1423
Cdd:TIGR02169  776 KLEEALNDLEARLSHSR-----IPEIQAELS--------KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELqeqr 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1424 -DTKNQI--LQEELLSMKT----VQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERarqeiAEKLKE 1496
Cdd:TIGR02169  843 iDLKEQIksIEKEIENLNGkkeeLEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ-----IEKKRK 917

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1497 VNLFLQAQAASQENLEQFRENNFASMKS---------QMELRIKDLESELSKIktsqEDFNKTELEKYKqlylEELKVRK 1567
Cdd:TIGR02169  918 RLSELKAKLEALEEELSEIEDPKGEDEEipeeelsleDVQAELQRVEEEIRAL----EPVNMLAIQEYE----EVLKRLD 989


                   ....*...
gi 2462517859 1568 SLSSKLTK 1575
Cdd:TIGR02169  990 ELKEKRAK 997
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 937-1597 6.93e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.39  E-value: 6.93e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  937 EKEKKCFEDLKIVKEKNEDLQKTI--------KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1008
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELALlvlrleelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1009 YHSRLAAAihdrdQSETSKRELELAFQRARDEcsrlqdkmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR 1088
Cdd:TIGR02168  286 LQKELYAL-----ANEISRLEQQKQILRERLA-------------NLERQLEELEAQLEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1089 EKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAhnkADNKEKTVINIQ 1168
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL---EDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1169 DQfhaivqkLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRY 1248
Cdd:TIGR02168  425 EL-------LKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERL 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1249 RINLEDETQDLKKKLgQIRNQLQEAQDRHTEAVRCAEK--------MQDHKQKLE--------------KDNAKLKVTV- 1305
Cdd:TIGR02168  498 QENLEGFSEGVKALL-KNQSGLSGILGVLSELISVDEGyeaaieaaLGGRLQAVVvenlnaakkaiaflKQNELGRVTFl 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1306 -----------KKQMDKIEELQKNLLNANLSEDEKEQLKKLME-----------LKQSLEC------------------- 1344
Cdd:TIGR02168  577 pldsikgteiqGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddLDNALELakklrpgyrivtldgdlvr 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1345 -----------------NLDQEMKKNV----ELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMDIQINKLK 1403
Cdd:TIGR02168  657 pggvitggsaktnssilERRREIEELEekieELEEKIAELEKALAELRKELEELEEEL----EQLRKELEELSRQISALR 732

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1404 HKIDDLTAELETAGSKCLHLDTKNQILQEEllsMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIE 1483
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELEAE---IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELR 809

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1484 ERARQ---EIAEKLKEVNLFLQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDFNKtELEKYKQLYL 1560
Cdd:TIGR02168  810 AELTLlneEAANLRERLESLERRIAATERRLEDLEEQ-----IEELSEDIESLAAEIEELEELIEELES-ELEALLNERA 883

                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 2462517859 1561 EELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1597
Cdd:TIGR02168  884 SLEEALALLRSELEELSEELRELESKRSELRRELEEL 920
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 75-209 1.06e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 66.06  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   75 DRDKMNrTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAV 154
Cdd:PHA02878   164 DRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517859  155 -YNEDISVATKLLLYDANIEAKNK-DDLTPLLLAVsgKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02878   243 gYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLN 297
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 841-1587 1.45e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 66.40  E-value: 1.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  841 EMELRTVKSNLNQVVQER--NDAQRQLSREQNARMLQDgiltnhlskqkeIEMAQKKMNsenshsheeekdLSHKNSMLQ 918
Cdd:pfam12128  192 EGKFRDVKSMIVAILEDDgvVPPKSRLNRQQVEHWIRD------------IQAIAGIMK------------IRPEFTKLQ 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  919 EEIAMLR---LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLEN- 994
Cdd:pfam12128  248 QEFNTLEsaeLRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEAl 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  995 EKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARD---ECSRLQDKM----NFDVSNLKDN----NEILS 1063
Cdd:pfam12128  328 EDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDvtaKYNRRRSKIkeqnNRDIAGIKDKlakiREARD 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1064 QQLFKTESKLNSLEIEFHHTRDA----LREKTLG----LERVQKDLSQTQCQMKEMEQKYQNeQVKVNKYIGKQESVEER 1135
Cdd:pfam12128  408 RQLAVAEDDLQALESELREQLEAgkleFNEEEYRlksrLGELKLRLNQATATPELLLQLENF-DERIERAREEQEAANAE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1136 LSQLQSEnmllRQQLDDAHNKADNKEKtviniqdQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKA 1215
Cdd:pfam12128  487 VERLQSE----LRQARKRRDQASEALR-------QASRRLEERQSALDELELQLFPQAGTLLHFLRKEAPDWEQSIGKVI 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1216 EREVVVR-QLQQELADTLKKQSMSEASLEVTSRyRINLED---ETQDLKKKLGQIRNQLQEAQDRHTEAvrcAEKMQDHK 1291
Cdd:pfam12128  556 SPELLHRtDLDPEVWDGSVGGELNLYGVKLDLK-RIDVPEwaaSEEELRERLDKAEEALQSAREKQAAA---EEQLVQAN 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1292 QKLekDNAKLKVTVKKQMDKIEELQKNLLNanlseDEKEQLKklMELKQSLECNLDQEMKKNVELEREitgfKNLLKMTR 1371
Cdd:pfam12128  632 GEL--EKASREETFARTALKNARLDLRRLF-----DEKQSEK--DKKNKALAERKDSANERLNSLEAQ----LKQLDKKH 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1372 KKLNEYENGEFSFHGDLKtsQFEMDIQINKLKHKIDDLTAELETAGSKclhLDTKNQILQEEllsMKTVQKKCEKLQKNK 1451
Cdd:pfam12128  699 QAWLEEQKEQKREARTEK--QAYWQVVEGALDAQLALLKAAIAARRSG---AKAELKALETW---YKRDLASLGVDPDVI 770

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1452 KKLEQEVINLRSHIERNMVELGQVKQYKQEIEER---ARQEIAEKLKEVN---LFLQAQAASQE-----NLEQFRENNFA 1520
Cdd:pfam12128  771 AKLKREIRTLERKIERIAVRRQEVLRYFDWYQETwlqRRPRLATQLSNIEraiSELQQQLARLIadtklRRAKLEMERKA 850

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517859 1521 SMKSQMEL--RIKDLESELSKIKTSQEDFNKTELE---KYKQLYLEELK-VRKSLSSKLTKTNERLAEVNTKL 1587
Cdd:pfam12128  851 SEKQQVRLseNLRGLRCEMSKLATLKEDANSEQAQgsiGERLAQLEDLKlKRDYLSESVKKYVEHFKNVIADH 923
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-280 1.85e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.04  E-value: 1.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   66 LLLRKNGLNDRDKMNRTALHLAcANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVH 145
Cdd:PLN03192   512 LLGDNGGEHDDPNMASNLLTVA-STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  146 GNTAL-------HYAVYN------------------------EDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQM 194
Cdd:PLN03192   591 GNTALwnaisakHHKIFRilyhfasisdphaagdllctaakrNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  195 VEFLIKKKANVNAVDKLES-SHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSwpTSDDEdlnfdtKNV 273
Cdd:PLN03192   671 VRLLIMNGADVDKANTDDDfSPTELRELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQG--TSSDN------QCR 742


                   ....*..
gi 2462517859  274 PKPSLAK 280
Cdd:PLN03192   743 PRVSIYK 749
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1070-1378 4.14e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.96  E-value: 4.14e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1070 ESKLNSLEIEfhhTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQ 1149
Cdd:COG1196    199 ERQLEPLERQ---AEKAERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1150 LDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELA 1229
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRR-ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1230 DTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQM 1309
Cdd:COG1196    355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1310 DKIEELQKNLLNANLSEDEKEQ-LKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYE 1378
Cdd:COG1196    435 EEEEEEEEALEEAAEEEAELEEeEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 799-1594 4.56e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.99  E-value: 4.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  799 EEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL-------------ELSLQTLEMELRTVKSNLNQVVQERNDaqrQL 865
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELklkeqakkaleyyQLKEKLELEEEYLLYLDYLKLNEERID---LL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  866 SREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENShshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFED 945
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEE---KEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  946 LKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIhdRDQSET 1025
Cdd:pfam02463  320 EKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK--LKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1026 SKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR-EKTLGLERVQKDLSQT 1104
Cdd:pfam02463  398 ELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLlKDELELKKSEDLLKET 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1105 QCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAhnKADNKEKTVINIQDQFHAIVQKLQAESEK 1184
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIIS--AHGRLGDLGVAVENYKVAISTAVIVEVSA 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1185 QSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDET--QDLKKK 1262
Cdd:pfam02463  556 TADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGilKDTELT 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1263 LGQIRNQLQEAQDRHTEAVRCAEKM-QDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQS 1341
Cdd:pfam02463  636 KLKESAKAKESGLRKGVSLEEGLAEkSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKL 715

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1342 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKcl 1421
Cdd:pfam02463  716 KLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKE-- 793

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1422 hldtKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFL 1501
Cdd:pfam02463  794 ----EKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELL 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1502 QAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSL--SSKLTKTNER 1579
Cdd:pfam02463  870 QELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPeeLLLEEADEKE 949

                          810
                   ....*....|....*
gi 2462517859 1580 LAEVNTKLLVEKQQS 1594
Cdd:pfam02463  950 KEENNKEEEEERNKR 964
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 39-214 8.39e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 8.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   39 GYHVRDRDLGK---IHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGH-PEVVTLLVDRKCQLNVCDNENR 114
Cdd:PHA02876   263 GFSVNSIDDCKntpLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYI 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  115 TALMKAVQCQEEKCATI-LLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQ 193
Cdd:PHA02876   343 TPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPY 422

                          170       180
                   ....*....|....*....|..
gi 2462517859  194 M-VEFLIKKKANVNAVDKLESS 214
Cdd:PHA02876   423 MsVKTLIDRGANVNSKNKDLST 444
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 741-1177 9.61e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.50  E-value: 9.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  741 LKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE 820
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  821 EQYRKEVEVKQQLELSLQTLEMEL------------RTVKSNLNQVVQERNDAQRQLSR-EQNARMLQDGIL-------- 879
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEIsdlnnqkeqdwnKELKSELKNQEKKLEEIQNQISQnNKIISQLNEQISqlkkeltn 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  880 --TNHLSKQKEIEMAQKKMNSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedLKIVKEKNEDLQ 957
Cdd:TIGR04523  354 seSENSEKQRELEEKQNEIEKLK----KENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKELLE 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  958 KTIKQneetLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE---TSKRELELAF 1034
Cdd:TIGR04523  426 KEIER----LKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQkelKSKEKELKKL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1035 QRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE-----IEFHHTRDALREKTLG-------LERVQKDLS 1102
Cdd:TIGR04523  502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEdelnkDDFELKKENLEKEIDEknkeieeLKQTQKSLK 581

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517859 1103 QTQCQMKEMEQKYQNEQVKVNK----YIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK 1177
Cdd:TIGR04523  582 KKQEEKQELIDQKEKEKKDLIKeieeKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNK 660
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 799-1414 1.10e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 1.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  799 EEKRRNADTL---------YEKIREQLRRKEEQYRkeVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQ 869
Cdd:COG1196    196 GELERQLEPLerqaekaerYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  870 NArmlqdgiltnHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQEKEkkcfedlkiv 949
Cdd:COG1196    274 LE----------LEELELELEEAQAEEYELLAELARLEQDIAR----LEERRRELEERLEELEEELAELE---------- 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  950 kEKNEDLQKTIKQNEETLTQtisqyngrlsvltaenamlnskLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRE 1029
Cdd:COG1196    330 -EELEELEEELEELEEELEE----------------------AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1030 LELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMK 1109
Cdd:COG1196    387 ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1110 EMEQKYQNEQVKVnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLL 1189
Cdd:COG1196    467 ELLEEAALLEAAL------AELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1190 EERNKELIsecnhlkeRQYQYENEKAEREVVVRQLQQELA-------DTLKKQSMSEASLE--VTSRYRINLEDETQDLK 1260
Cdd:COG1196    541 EAALAAAL--------QNIVVEDDEVAAAAIEYLKAAKAGratflplDKIRARAALAAALArgAIGAAVDLVASDLREAD 612

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1261 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE------------KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDE 1328
Cdd:COG1196    613 ARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsagGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1329 KEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDD 1408
Cdd:COG1196    693 LELEEALLAEEEEER-ELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELER 771


                   ....*.
gi 2462517859 1409 LTAELE 1414
Cdd:COG1196    772 LEREIE 777
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 125-210 1.10e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.98  E-value: 1.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  125 EEKCATILLEHGADPNLADVH-GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02878   146 EAEITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225


                   ....*..
gi 2462517859  204 NVNAVDK 210
Cdd:PHA02878   226 STDARDK 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 55-179 1.44e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 1.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   55 SAGNVAKVqqILLLRKNG--LNDRDKMNRTALHL-ACANGHPEVVTLLVDRKCQLNVCDNENRTALMK--AVQCQEEKCA 129
Cdd:PHA03095    58 SSEKVKDI--VRLLLEAGadVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVI 135

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462517859  130 TILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDD 179
Cdd:PHA03095   136 RLLLRKGADVNALDLYGMTPLAVLLKSRNANVELLRLLIDAGADVYAVDD 185
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 712-1275 2.46e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.44  E-value: 2.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  712 IEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKS----QLEHQKVEWERE 787
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieELEKQLVLANSE 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  788 LCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQL---------------------ELSLQTLEMELRT 846
Cdd:pfam15921  358 LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLwdrdtgnsitidhlrrelddrNMEVQRLEALLKA 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  847 VKSNlnqvVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI------EMAQKKMNSENShsheeEKDLSHKNSMLQE- 919
Cdd:pfam15921  438 MKSE----CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMlrkvveELTAKKMTLESS-----ERTVSDLTASLQEk 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  920 ---------EIAMLRLEIDT-------IKNQN---QEKEKKCfEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSV 980
Cdd:pfam15921  509 eraieatnaEITKLRSRVDLklqelqhLKNEGdhlRNVQTEC-EALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGA 587

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  981 LTAENAMLNSK-------------LENEKQSKER-LEAEV---ESYHSRLAAAIHDRDQS----ETSKRELELAFQRARD 1039
Cdd:pfam15921  588 MQVEKAQLEKEindrrlelqefkiLKDKKDAKIReLEARVsdlELEKVKLVNAGSERLRAvkdiKQERDQLLNEVKTSRN 667

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1040 ECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALR----------------EKTLGLERVQKDLSQ 1103
Cdd:pfam15921  668 ELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKsmegsdghamkvamgmQKQITAKRGQIDALQ 747

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1104 TQCQMKEMEQKYQNEQV-----KVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQF---HAIV 1175
Cdd:pfam15921  748 SKIQFLEEAMTNANKEKhflkeEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFaecQDII 827

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1176 QKLQAESEKQSLLLEERNKEL----ISECNHLKERQYQYENEKAEREVVVRQlqQELADTLKKQSMSEASLEvtsryrin 1251
Cdd:pfam15921  828 QRQEQESVRLKLQHTLDVKELqgpgYTSNSSMKPRLLQPASFTRTHSNVPSS--QSTASFLSHHSRKTNALK-------- 897

                          650       660
                   ....*....|....*....|....
gi 2462517859 1252 lEDETQDLKKKLGQIRNQLQEAQD 1275
Cdd:pfam15921  898 -EDPTRDLKQLLQELRSVINEEPT 920
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 817-1240 2.51e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.39  E-value: 2.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  817 RRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSReqnarmlqdgiltnhlsKQKEIEMAQKKM 896
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGE-----------------IEKEIEQLEQEE 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  897 NSENshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEkkcfEDLKIVKEKNEDLqktikqneetltqtisqyng 976
Cdd:TIGR02169  733 EKLK----ERLEELEEDLSSLEQEIENVKSELKELEARIEELE----EDLHKLEEALNDL-------------------- 784

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  977 rlsvltaENAMLNSKLENEKQSKErleaEVESYHSRLAAAIHDRDQsETSKRELELAFqrARDECSRLQDKMNfdvsNLK 1056
Cdd:TIGR02169  785 -------EARLSHSRIPEIQAELS----KLEEEVSRIEARLREIEQ-KLNRLTLEKEY--LEKEIQELQEQRI----DLK 846

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1057 DNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERL 1136
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL 926

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1137 SQLQSENMLLrqqldDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKqsllLEERNKELISECNHLKERQYQYENEKAE 1216
Cdd:TIGR02169  927 EALEEELSEI-----EDPKGEDEEIPEEELSLEDVQAELQRVEEEIRA----LEPVNMLAIQEYEEVLKRLDELKEKRAK 997

                          410       420
                   ....*....|....*....|....*.
gi 2462517859 1217 REVVVRQLQQELA--DTLKKQSMSEA 1240
Cdd:TIGR02169  998 LEEERKAILERIEeyEKKKREVFMEA 1023
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 50-214 3.14e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.22  E-value: 3.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNVAKVQQILllrKNG--LNDRDKMNRTALHLACANGH-----PEVVTLLVDRKCQLNVCDNENRTALMKAVQ 122
Cdd:PHA03100    39 LYLAKEARNIDVVKILL---DNGadINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  123 CQEEKCATI--LLEHGADPNLADVHGNTALHYAV---------------YNEDISVATK---LLLYDANIEAKNKDDLTP 182
Cdd:PHA03100   116 KKSNSYSIVeyLLDNGANVNIKNSDGENLLHLYLesnkidlkilkllidKGVDINAKNRvnyLLSYGVPINIKDVYGFTP 195

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2462517859  183 LLLAVSGKKQQMVEFLIKKKANVNAVDKLESS 214
Cdd:PHA03100   196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 812-1491 3.52e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 61.66  E-value: 3.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  812 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDGILTNHLSKQKEiem 891
Cdd:pfam05483   97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKD----LIKENNATRHLCNLLKETCARSAE--- 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  892 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 971
Cdd:pfam05483  170 KTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAE---NARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLL 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  972 SQYNGRlsvltaENAM--LNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMN 1049
Cdd:pfam05483  247 IQITEK------ENKMkdLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQ 320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1050 F---DVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALrEKTLGLERVQKDLSQTQCQMKEME-QKYQNEQVKVNKY 1125
Cdd:pfam05483  321 IatkTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL-EELLRTEQQRLEKNEDQLKIITMElQKKSSELEEMTKF 399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1126 IGKQESVEERLSQLQSENMLLRQQLDDAHNKADN--------------KEKTVINIQDQFHAI----------VQKLQAE 1181
Cdd:pfam05483  400 KNNKEVELEELKKILAEDEKLLDEKKQFEKIAEElkgkeqelifllqaREKEIHDLEIQLTAIktseehylkeVEDLKTE 479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1182 SEKQSLlleeRNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKK 1261
Cdd:pfam05483  480 LEKEKL----KNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVRE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1262 KLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDkieelQKNLLNANLSEDEKEQLKKLMELKQS 1341
Cdd:pfam05483  556 EFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIE-----NKNKNIEELHQENKALKKKGSAENKQ 630

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1342 LECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQIN-------KLKHKIDDLTAELE 1414
Cdd:pfam05483  631 LNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKlqkeidkRCQHKIAEMVALME 710

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517859 1415 TagskclHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1491
Cdd:pfam05483  711 K------HKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTA 781
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-211 3.54e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.62  E-value: 3.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNvAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNvcdnENRTALMKAVQCQEEKCA 129
Cdd:PHA02876   182 IHYAAERGN-AKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLLKAIRNEDLETS 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  130 TILLEHGADPNLADVHGNTALHYAVYNEDIS-VATKLLLYDANIEAKNKDDLTPL-LLAVSGKKQQMVEFLIKKKANVNA 207
Cdd:PHA02876   257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA 336


                   ....
gi 2462517859  208 VDKL 211
Cdd:PHA02876   337 ADRL 340
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 752-1575 3.63e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 61.99  E-value: 3.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  752 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEwerELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEvkq 831
Cdd:TIGR00606  263 KIMKLDNEIKALKSRKKQMEKDNSELELKMEK---VFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERR--- 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  832 qlELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI----EMAQKKMNSENSHSHEEE 907
Cdd:TIGR00606  337 --LLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIknfhTLVIERQEDEAKTAAQLC 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  908 KDLSHKNSMLQEEIAMLRLEI----DTIKNQNQEKEKKCfEDLKIVKEKNEDLQ---KTIKQNEETLTQTISQYNgrlsv 980
Cdd:TIGR00606  415 ADLQSKERLKQEQADEIRDEKkglgRTIELKKEILEKKQ-EELKFVIKELQQLEgssDRILELDQELRKAERELS----- 488

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  981 LTAENAMLNSKLENEKqSKERLEAEVESYHSRLAAAIHDRDQSETSKRELEL-------AFQRARDECSRLQDKMNFDVS 1053
Cdd:TIGR00606  489 KAEKNSLTETLKKEVK-SLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMltkdkmdKDEQIRKIKSRHSDELTSLLG 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1054 -------------NLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTqCQMKEMEQKYQNEQV 1120
Cdd:TIGR00606  568 yfpnkkqledwlhSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDV-CGSQDEESDLERLKE 646

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1121 KVNK-------YIGKQESVEERLSQLQSEN----------MLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESE 1183
Cdd:TIGR00606  647 EIEKsskqramLAGATAVYSQFITQLTDENqsccpvcqrvFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRD 726

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1184 KQSLLLEERNKEL---ISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-EVTSRYRinLEDETQDL 1259
Cdd:TIGR00606  727 EMLGLAPGRQSIIdlkEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLtDVTIMER--FQMELKDV 804

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1260 KKKLGQIRNQLQEAQ-DRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMEL 1338
Cdd:TIGR00606  805 ERKIAQQAAKLQGSDlDRTVQQVN--QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQR 882

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1339 KQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGS 1418
Cdd:TIGR00606  883 RQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIEN 962

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1419 KClhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLR-----SHIERNMVELGQVKQYKQEIEERARQEIAEK 1493
Cdd:TIGR00606  963 KI--QDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRqdidtQKIQERWLQDNLTLRKRENELKEVEEELKQH 1040

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1494 LKEVNlflQAQAASQENLEQFRENNFASMKSQMEL---RIKDLESEL--SKIKTSQEDFNKTElEKYKQLYLeELKVRKS 1568
Cdd:TIGR00606 1041 LKEMG---QMQVLQMKQEHQKLEENIDLIKRNHVLalgRQKGYEKEIkhFKKELREPQFRDAE-EKYREMMI-VMRTTEL 1115


                   ....*..
gi 2462517859 1569 LSSKLTK 1575
Cdd:TIGR00606 1116 VNKDLDI 1122
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-209 3.95e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 3.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNVAKVQQiLLLRKNG-LNDRDKMNRTALH--LACANGHPEVVTLLVDRKCQLNVCDNENRT---ALMKAVQC 123
Cdd:PHA03095    87 LHLYLYNATTLDVIK-LLIKAGAdVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTplaVLLKSRNA 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  124 QEE----------------------------------KCATILLEHGADPNLADVHGNTALHYAVYNEDI--SVATKLLL 167
Cdd:PHA03095   166 NVEllrllidagadvyavddrfrsllhhhlqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGSSCkrSLVLPLLI 245

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462517859  168 YDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA03095   246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
944-1516 4.94e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 61.23  E-value: 4.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  944 EDLKIVKEKNEDLQKTIKQNEETLTQTISqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVEsyhsRLAAAIHDRDQS 1023
Cdd:PRK03918   179 ERLEKFIKRTENIEELIKEKEKELEEVLR----EINEISSELPELREELEKLEKEVKELEELKE----EIEELEKELESL 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1024 ETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEIlsQQLFKTESKLNSLEIEFhhtRDALREKTLGLERVQKDLSQ 1103
Cdd:PRK03918   251 EGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEY---LDELREIEKRLSRLEEEING 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1104 TQCQMKEMEQKyqneQVKVNKYIGKQESVEERLSQLQSENMLLrqqlDDAHNKADNKEKTVINIQDQfhaIVQKLQAESE 1183
Cdd:PRK03918   326 IEERIKELEEK----EERLEELKKKLKELEKRLEELEERHELY----EEAKAKKEELERLKKRLTGL---TPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1184 KqsllLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ----------QELADTLKKQSMSEASLEVT--SRYRIN 1251
Cdd:PRK03918   395 E----LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKELLEEYTAELKriEKELKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1252 LEDETQDLKKKLGQIRNQLQEaQDRHTEAVRCAEKMQDHKQKLEKDN-------AKLKVTVKKQMDKIEELQKNLlnanl 1324
Cdd:PRK03918   471 IEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLKELEEKLKKYNleelekkAEEYEKLKEKLIKLKGEIKSL----- 544

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1325 sEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREIT--GFKNL--LKMTRKKLNEYENGEFSfhgdLKTSQFEMDIQIN 1400
Cdd:PRK03918   545 -KKELEKLEELKKKLAELEKKLDELEEELAELLKELEelGFESVeeLEERLKELEPFYNEYLE----LKDAEKELEREEK 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1401 KLKhkidDLTAELETAGSKCLHLDTKNQILQEEL--LSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQY 1478
Cdd:PRK03918   620 ELK----KLEEELDKAFEELAETEKRLEELRKELeeLEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKT 695

                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 2462517859 1479 KQEIEERaRQEIAEKLKEVNLFLQAQAASQENLEQFRE 1516
Cdd:PRK03918   696 LEKLKEE-LEEREKAKKELEKLEKALERVEELREKVKK 732
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 748-1368 9.29e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 60.62  E-value: 9.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  748 LLTVKIKKMEDKVNVLQRELSET-KEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKE----EQ 822
Cdd:pfam12128  262 HLHFGYKSDETLIASRQEERQETsAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLdadiET 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  823 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVvQERNDAQRQLSREQNARMLQDgiLTNHLSKQKEiemaqkkmnsensh 902
Cdd:pfam12128  342 AAADQEQLPSWQSELENLEERLKALTGKHQDV-TAKYNRRRSKIKEQNNRDIAG--IKDKLAKIRE-------------- 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  903 shEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTikqnEETLTQTisqyngrlsvlt 982
Cdd:pfam12128  405 --ARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATAT----PELLLQL------------ 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  983 aenAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDK-----------MNFD 1051
Cdd:pfam12128  467 ---ENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQlfpqagtllhfLRKE 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1052 VSNLKDN--NEILSQQLFKT-------------ESKLNSLEI--------EFHHTRDALREKtlgLERVQKDLSQTQCQM 1108
Cdd:pfam12128  544 APDWEQSigKVISPELLHRTdldpevwdgsvggELNLYGVKLdlkridvpEWAASEEELRER---LDKAEEALQSAREKQ 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1109 KEMEQkyqnEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAH-NKADNKEKTVINIQDQFHAIVQKLQAESE---- 1183
Cdd:pfam12128  621 AAAEE----QLVQANGELEKASREETFARTALKNARLDLRRLFDEKqSEKDKKNKALAERKDSANERLNSLEAQLKqldk 696

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1184 KQSLLLEERNKELISecnHLKERQYQYENEKAEREVVVRQLQQELA----------DTLKKQSMSE-ASLEVTSRYRINL 1252
Cdd:pfam12128  697 KHQAWLEEQKEQKRE---ARTEKQAYWQVVEGALDAQLALLKAAIAarrsgakaelKALETWYKRDlASLGVDPDVIAKL 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1253 EDETQDLKKKLGQIrnqlqeAQDRHteAVRCAEKMQDHKQKLEKDNakLKVTVKKQMDKIEELQKNLlnANLSEDEKEQL 1332
Cdd:pfam12128  774 KREIRTLERKIERI------AVRRQ--EVLRYFDWYQETWLQRRPR--LATQLSNIERAISELQQQL--ARLIADTKLRR 841

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 2462517859 1333 KKLMELKQSLEcnldqemKKNVELEREITGFKNLLK 1368
Cdd:pfam12128  842 AKLEMERKASE-------KQQVRLSENLRGLRCEMS 870
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
800-1368 9.49e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.46  E-value: 9.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  800 EKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR-EQNARMLQdgi 878
Cdd:PRK03918   158 DDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKlEKEVKELE--- 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  879 ltnhlSKQKEIEMAQKKMNSENSHSHEEEKDLSHknsmLQEEIAMLRLEIDTIKNQNQE-----KEKKCFEDLKIVKEKN 953
Cdd:PRK03918   235 -----ELKEEIEELEKELESLEGSKRKLEEKIRE----LEERIEELKKEIEELEEKVKElkelkEKAEEYIKLSEFYEEY 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  954 EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLE----------------AEVESYHSRLAA-- 1015
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhelyeeakakkEELERLKKRLTGlt 385

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1016 ---AIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTL 1092
Cdd:PRK03918   386 pekLEKELEELEKAKEEIEEEISKITARIGELKKE----IKELKKAIEELKKA--KGKCPVCGRELTEEHRKELLEEYTA 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1093 GLERVQKDLSQTqcqmKEMEQKYQNEQVKVNKYIGKQ-------------ESVEERLSQLQSENM--------LLRQQLD 1151
Cdd:PRK03918   460 ELKRIEKELKEI----EEKERKLRKELRELEKVLKKEseliklkelaeqlKELEEKLKKYNLEELekkaeeyeKLKEKLI 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1152 DAHNKADNKEKTVINIQD---QFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYEnEKAEREVVVRQLQQEL 1228
Cdd:PRK03918   536 KLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKEL 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1229 ADTLKKQSMSEASLEVTsryrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRcaEKMQDHKQKLEKDNAKLKVTVKKQ 1308
Cdd:PRK03918   615 EREEKELKKLEEELDKA-------FEELAETEKRLEELRKELEELEKKYSEEEY--EELREEYLELSRELAGLRAELEEL 685

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1309 MDKIEELQKNLlnanlsEDEKEQLKKLMELKQSLEcNLDQEMKKNVELEREITGFKNLLK 1368
Cdd:PRK03918   686 EKRREEIKKTL------EKLKEELEEREKAKKELE-KLEKALERVEELREKVKKYKALLK 738
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 129-282 1.01e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.30  E-value: 1.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  129 ATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVeflikkkanvnav 208
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV------------- 164

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517859  209 dklesshQLISEYKEEripkHSSQNSNSVDESsedslsrLSGKPGVDDSWPTSDDEDlnfDTKNVPKPSLAKLM 282
Cdd:PTZ00322   165 -------QLLSRHSQC----HFELGANAKPDS-------FTGKPPSLEDSPISSHHP---DFSAVPQPMMGSLI 217
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 907-1597 2.26e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.96  E-value: 2.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  907 EKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEkNEDLqktIKQNEETltqtiSQYNGRLSVLTAENA 986
Cdd:pfam05483   98 EAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQE-NKDL---IKENNAT-----RHLCNLLKETCARSA 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  987 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHD-RDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQ 1065
Cdd:pfam05483  169 EKTKKYEYEREETRQVYMDLNNNIEKMILAFEElRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQ 248

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1066 LFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenml 1145
Cdd:pfam05483  249 ITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQI------- 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1146 lrqqlddahnkadnKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQ 1225
Cdd:pfam05483  322 --------------ATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQ 387

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1226 QEladtlkkqsmsEASLEVTSRYRINLEDETQDLKKKLG----------QIRNQLQEAQDRHTEAVRCAEKMQDHKQKLE 1295
Cdd:pfam05483  388 KK-----------SSELEEMTKFKNNKEVELEELKKILAedeklldekkQFEKIAEELKGKEQELIFLLQAREKEIHDLE 456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1296 KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE-ITGFKNLLKMTRKKL 1374
Cdd:pfam05483  457 IQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEdIINCKKQEERMLKQI 536

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1375 NEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKtvqKKCEKLQKNKKKL 1454
Cdd:pfam05483  537 ENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLK---KQIENKNKNIEEL 613

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1455 EQE--VINLRSHIERNMVELGQVKQYKQEIE-ERARQEIAEKLKEVNLFLQAQAASQENL----EQFRENNFASMKSQME 1527
Cdd:pfam05483  614 HQEnkALKKKGSAENKQLNAYEIKVNKLELElASAKQKFEEIIDNYQKEIEDKKISEEKLleevEKAKAIADEAVKLQKE 693

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517859 1528 L------RIKDLESELSKIKTSQEDF---NKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSL 1597
Cdd:pfam05483  694 IdkrcqhKIAEMVALMEKHKHQYDKIieeRDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKL 772
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 817-1566 2.88e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 59.03  E-value: 2.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  817 RRKEEQYRKEVEVKQQLELSLQtLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 896
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQK-AESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHEL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  897 NSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQE----------KEKKCFEDLKIVKEKNEDLQKTIKQNEEt 966
Cdd:pfam01576   81 ESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKlqlekvtteaKIKKLEEDILLLEDQNSKLSKERKLLEE- 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  967 ltqtisqyngRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQD 1046
Cdd:pfam01576  160 ----------RISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQA 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1047 KMnfdvsnlkdnnEILSQQLFKTESKLNSLEiefhhtrDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYI 1126
Cdd:pfam01576  230 QI-----------AELRAQLAKKEEELQAAL-------ARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAE 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1127 GKQESVEERLSQLQSEnmlLRQQLDDAHNKAD---NKEKTVIN----IQDQFHAIVQKLQAESEKQSLLLEERNKELise 1199
Cdd:pfam01576  292 KQRRDLGEELEALKTE---LEDTLDTTAAQQElrsKREQEVTElkkaLEEETRSHEAQLQEMRQKHTQALEELTEQL--- 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1200 cNHLKERQYQYENEKAEREVVVRQLQQELadtlkkQSMSEASLEVTSRyRINLEDETQDLKKKLGQIRNQLQEAQDRHTE 1279
Cdd:pfam01576  366 -EQAKRNKANLEKAKQALESENAELQAEL------RTLQQAKQDSEHK-RKKLEGQLQELQARLSESERQRAELAEKLSK 437

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1280 AVRCAEKMQDHKQKLEKDNAKLK---VTVKKQMDKIEELQKNLLNANLSEDEKeqLKKLMELKQSLECNLDQEMKKNVEL 1356
Cdd:pfam01576  438 LQSELESVSSLLNEAEGKNIKLSkdvSSLESQLQDTQELLQEETRQKLNLSTR--LRQLEDERNSLQEQLEEEEEAKRNV 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1357 EREITGFKNLLKMTRKKLNEYENGEFSFHGDLKtsqfemdiqinKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL-- 1434
Cdd:pfam01576  516 ERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKK-----------RLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELdd 584

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1435 LSMKTVQKK--CEKLQKNKKKLEQEVINlrshiERNMVelgqvkqyKQEIEERARQEIAEKLKEVNlFLQAQAASQENLE 1512
Cdd:pfam01576  585 LLVDLDHQRqlVSNLEKKQKKFDQMLAE-----EKAIS--------ARYAEERDRAEAEAREKETR-ALSLARALEEALE 650

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517859 1513 QfrennfasmKSQMELRIKDLESELSKIKTSQEDFNKT--ELEKYKQLY---LEELKVR 1566
Cdd:pfam01576  651 A---------KEELERTNKQLRAEMEDLVSSKDDVGKNvhELERSKRALeqqVEEMKTQ 700
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 73-218 3.83e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.67  E-value: 3.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   73 LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHY 152
Cdd:PHA02874   117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517859  153 AVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSgKKQQMVEFLIKKKA-NVNAVDKLESSHQLI 218
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-HNRSAIELLINNASiNDQDIDGSTPLHHAI 262
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1051-1583 1.07e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.00  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1051 DVSNLKDNNEilsQQLFKTESKLNSLEIEfhhtRDALREKTLGLERVQKDLsqtqcqmKEMEQKYQNEQVKVNKYIGKQE 1130
Cdd:PRK03918   190 NIEELIKEKE---KELEEVLREINEISSE----LPELREELEKLEKEVKEL-------EELKEEIEELEKELESLEGSKR 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1131 SVEERLSQLQSENMLLRQQLDDAHNKAdnKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQY 1210
Cdd:PRK03918   256 KLEEKIRELEERIEELKKEIEELEEKV--KELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEL 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1211 ENEKAErevvVRQLQQELADTLKKQSMSEASLEVTSRYRiNLEDETQDLKKKLGQirNQLQEAQDRHTEAVRCAEKMQDH 1290
Cdd:PRK03918   334 EEKEER----LEELKKKLKELEKRLEELEERHELYEEAK-AKKEELERLKKRLTG--LTPEKLEKELEELEKAKEEIEEE 406

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1291 KQKLEKDNAKLKVTVKKQMDKIEELQKN-----LLNANLSEDEKEQL--------KKLMELKQSLECNLDQEMKKNVELE 1357
Cdd:PRK03918   407 ISKITARIGELKKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELleeytaelKRIEKELKEIEEKERKLRKELRELE 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1358 REITGFKNLLKMtRKKLNEYENGEFSFHGdlktsqfemdIQINKLKHKiddlTAELETAGSKCLHLDTKNQILQEELLSM 1437
Cdd:PRK03918   487 KVLKKESELIKL-KELAEQLKELEEKLKK----------YNLEELEKK----AEEYEKLKEKLIKLKGEIKSLKKELEKL 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1438 KTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVE-LGQVKQYKQEIEERARQEIaeKLKEVNLFLQAQAASQENLEQFRE 1516
Cdd:PRK03918   552 EELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEYL--ELKDAEKELEREEKELKKLEEELD 629

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517859 1517 NNFAsmksQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEV 1583
Cdd:PRK03918   630 KAFE----ELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEI 692
Ank_2 pfam12796
Ankyrin repeats (3 copies);
150-210 1.34e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.88  E-value: 1.34e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462517859  150 LHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIkKKANVNAVDK 210
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDN 60
Ank_4 pfam13637
Ankyrin repeats (many copies);
113-166 2.41e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 2.41e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517859  113 NRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLL 166
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
730-1280 3.82e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.05  E-value: 3.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  730 DAALSCERLLELKKNHCELLTVKIKKMEDK-----VNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 804
Cdd:PRK02224   173 DARLGVERVLSDQRGSLDQLKAQIEEKEEKdlherLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  805 ADTLYEKIRE------QLRRKEEQYRKEVEVKQQLELSLQTLEMELRTvKSNLNQVVQERNDAQRQ-LSREQNArmLQDG 877
Cdd:PRK02224   253 LETLEAEIEDlretiaETEREREELAEEVRDLRERLEELEEERDDLLA-EAGLDDADAEAVEARREeLEDRDEE--LRDR 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  878 ILtnhlskqkEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKnqnqekekkcfEDLKIVKEKNEDLQ 957
Cdd:PRK02224   330 LE--------ECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAR-----------EAVEDRREEIEELE 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  958 KTIKQNEETLTQTISQYNGrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA--------------------- 1016
Cdd:PRK02224   391 EEIEELRERFGDAPVDLGN----AEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpvegsph 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1017 IHDRDQSETSKRELELAFQRARDECSRLQDKMNfdvsnlkdnneiLSQQLFKTESKLNSLE---------IEFHHTRDAL 1087
Cdd:PRK02224   467 VETIEEDRERVEELEAELEDLEEEVEEVEERLE------------RAEDLVEAEDRIERLEerredleelIAERRETIEE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1088 REKTLGLERVQKDLSQTQCQMK-----EMEQKYQNEQVKVNKYIGKQESVEERLSQLQSenmlLRQQLDDAHNKADN--- 1159
Cdd:PRK02224   535 KRERAEELRERAAELEAEAEEKreaaaEAEEEAEEAREEVAELNSKLAELKERIESLER----IRTLLAAIADAEDEier 610

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1160 ---KEKTVINIQDQFHaivQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAERevvVRQLQQELADTLKKQS 1236
Cdd:PRK02224   611 lreKREALAELNDERR---ERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEK---LDELREERDDLQAEIG 684

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....
gi 2462517859 1237 MSEASLEvtsryrinledETQDLKKKLGQIRNQLQEAQDRHTEA 1280
Cdd:PRK02224   685 AVENELE-----------ELEELRERREALENRVEALEALYDEA 717
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 725-1397 5.99e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 54.59  E-value: 5.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  725 LLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRN 804
Cdd:pfam02463  355 EEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEE 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  805 A--DTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEmELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNH 882
Cdd:pfam02463  435 EeeSIELKQGKLTEEKEELEKQELKLLKDELELKKSEDL-LKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLL 513

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  883 LSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQ 962
Cdd:pfam02463  514 ALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKS 593

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  963 NEETLTQTISQYNGRLsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECS 1042
Cdd:pfam02463  594 IAVLEIDPILNLAQLD--KATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSEL 671

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1043 RLQDKmnfdvsNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKV 1122
Cdd:pfam02463  672 TKELL------EIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKI 745

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1123 NKYIGK-QESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECN 1201
Cdd:pfam02463  746 DEEEEEeEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIE 825

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1202 HLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----SLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDR 1276
Cdd:pfam02463  826 QEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITkeellQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEE 905

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1277 HTEAV-------RCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL---------MELKQ 1340
Cdd:pfam02463  906 SQKLNlleekenEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEElgkvnlmaiEEFEE 985

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462517859 1341 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDI 1397
Cdd:pfam02463  986 KEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSINKGWNKVFFYLEL 1042
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-210 8.48e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 8.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   66 LLLRK-NGLNDRDKMNRTALHLACANGHP--EVVTLLVDRKCQLNVCDNENRTAL-MKAVQCQeekCATI----LLEHGA 137
Cdd:PHA03095   172 LLIDAgADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLhSMATGSS---CKRSlvlpLLIAGI 248

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517859  138 DPNLADVHGNTALHYA-VYNEDISVAtKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDK 210
Cdd:PHA03095   249 SINARNRYGQTPLHYAaVFNNPRACR-RLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
Ank_5 pfam13857
Ankyrin repeats (many copies);
132-186 1.08e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 1.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517859  132 LLEHG-ADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLA 186
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 121-292 1.31e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  121 VQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIK 200
Cdd:PHA02876   153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  201 KKANVNAVDkLESSHQLISEYKEERIPKHSSQNS-NSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLA 279
Cdd:PHA02876   233 NRSNINKND-LSLLKAIRNEDLETSLLLYDAGFSvNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPL 311

                          170
                   ....*....|...
gi 2462517859  280 KLMTASQQSRKNL 292
Cdd:PHA02876   312 YLMAKNGYDTENI 324
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1310-1601 1.55e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 1.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1310 DKIEELQKNLLNANLsEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSfhgdLK 1389
Cdd:COG1196    220 EELKELEAELLLLKL-RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE----LL 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1390 TSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNM 1469
Cdd:COG1196    295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1470 VELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENnfasmKSQMELRIKDLESELSKIKTSQEDfnk 1549
Cdd:COG1196    375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEE-----LEELEEALAELEEEEEEEEEALEE--- 446

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462517859 1550 tELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNtKLLVEKQQSRSLFTTL 1601
Cdd:COG1196    447 -AAEEEAELEEEEEALLELLAELLEEAALLEAALA-ELLEELAEAAARLLLL 496
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 746-1359 1.72e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  746 CELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFslnQEEEKRRNADTLYEKIREQLRRKEEQYRK 825
Cdd:pfam05483  157 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRV---QAENARLEMHFKLKEDHEKIQHLEEEYKK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  826 EVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNarmLQDGILTNHLSKQKEIEMAQKKMNSENSHSHE 905
Cdd:pfam05483  234 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK---LQDENLKELIEKKDHLTKELEDIKMSLQRSMS 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  906 EEKDLSHKNSMLQEEIAMLRLEidtiKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAEN 985
Cdd:pfam05483  311 TQKALEEDLQIATKTICQLTEE----KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMEL 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  986 AMLNSKLENEKQSKERLEAEVESYHSRLA---AAIHDRDQSETSKREL-----ELAFQRARDECSRLQDKMNFDVSNLKD 1057
Cdd:pfam05483  387 QKKSSELEEMTKFKNNKEVELEELKKILAedeKLLDEKKQFEKIAEELkgkeqELIFLLQAREKEIHDLEIQLTAIKTSE 466

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1058 NNEILSQQLFKTE---SKLNSLEIEFHHTRDALREK---------TLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY 1125
Cdd:pfam05483  467 EHYLKEVEDLKTElekEKLKNIELTAHCDKLLLENKeltqeasdmTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNL 546

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1126 IGKQESVEERLSQLQSEnmlLRQQLDDAHNKADNKEKTVINIQDQFHAIVQK---LQAESEKQSLLLEernkELISECNH 1202
Cdd:pfam05483  547 RDELESVREEFIQKGDE---VKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnLKKQIENKNKNIE----ELHQENKA 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1203 LKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslEVTSRYRINLEDETQDLKKKLGQIrnqlQEAQDRHTEAVR 1282
Cdd:pfam05483  620 LKKKGSAENKQLNAYEIKVNKLELELASAKQKFE------EIIDNYQKEIEDKKISEEKLLEEV----EKAKAIADEAVK 689

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517859 1283 CAEKMQDHKQKLEKDNAKLKVTVKKQMDKI-EELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE 1359
Cdd:pfam05483  690 LQKEIDKRCQHKIAEMVALMEKHKHQYDKIiEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKE 767
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 619-1307 2.14e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 53.13  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  619 EKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDvddltQSSETASEDC 698
Cdd:TIGR01612 1061 EKEIGKNIELLNKEILEEAEINITNFNEIKEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQ-----KIDHHIKALE 1135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  699 ELPHSSyknfmlliEQLGMECKDSVS-LLKIQDAALSCERLLELKKNHCELLTV--KIKKMEDKVNVLQRELSETKEIKS 775
Cdd:TIGR01612 1136 EIKKKS--------ENYIDEIKAQINdLEDVADKAISNDDPEEIEKKIENIVTKidKKKNIYDEIKKLLNEIAEIEKDKT 1207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  776 QLEHQK---VEWERELCSLrFSLNQEEEKRRNADTL-----YEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTV 847
Cdd:TIGR01612 1208 SLEEVKginLSYGKNLGKL-FLEKIDEEKKKSEHMIkameaYIEDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDD 1286

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  848 KSnlNQVVQERNDAQRQLSREQNARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRL- 926
Cdd:TIGR01612 1287 KD--HHIISKKHDENISDIREKSLKIIED------FSEESDINDIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLn 1358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  927 EIDTIKNQNQEKEKKCFEDLKIVK---EKNEDLQKTIKQNE--ETLTQTISQyngrlsvlTAENAMLNSKLENEKQSKER 1001
Cdd:TIGR01612 1359 KIKKIIDEVKEYTKEIEENNKNIKdelDKSEKLIKKIKDDInlEECKSKIES--------TLDDKDIDECIKKIKELKNH 1430

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1002 LEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA----RDECSRLQDKMNFDVSNLKDNNEilSQQLFKTESKLNSLE 1077
Cdd:TIGR01612 1431 ILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSqhilKIKKDNATNDHDFNINELKEHID--KSKGCKDEADKNAKA 1508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1078 IEfhhtrdalREKTLgLERVQKDLSQTQCQMKEMEQKYQNEQVKV-------------NKYIGKQESVEERLSQLQSENM 1144
Cdd:TIGR01612 1509 IE--------KNKEL-FEQYKKDVTELLNKYSALAIKNKFAKTKKdseiiikeikdahKKFILEAEKSEQKIKEIKKEKF 1579

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1145 llrqQLDDAHNKADNKEKTVINIQdqfhaivqkLQAESEKQSLLLEERNKELISECnhLKERQyqyENEKAEREVVVRQL 1224
Cdd:TIGR01612 1580 ----RIEDDAAKNDKSNKAAIDIQ---------LSLENFENKFLKISDIKKKINDC--LKETE---SIEKKISSFSIDSQ 1641

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1225 QQELADTLKKQSMSEASLEVTSRYRINLED---ETQDLKKKLGQIRNQLQEAQDRHTEAV--RCAEKMQDHKQKLEKDNA 1299
Cdd:TIGR01612 1642 DTELKENGDNLNSLQEFLESLKDQKKNIEDkkkELDELDSEIEKIEIDVDQHKKNYEIGIieKIKEIAIANKEEIESIKE 1721


                   ....*...
gi 2462517859 1300 KLKVTVKK 1307
Cdd:TIGR01612 1722 LIEPTIEN 1729
Ank_5 pfam13857
Ankyrin repeats (many copies);
68-117 2.44e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.19  E-value: 2.44e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517859   68 LRKNG---LNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTAL 117
Cdd:pfam13857    1 LLEHGpidLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
50-100 2.51e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 2.51e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462517859   50 IHKAASAGNVAKVQqilLLRKNG--LNDRDKMNRTALHLACANGHPEVVTLLV 100
Cdd:pfam13637    5 LHAAAASGHLELLR---LLLEKGadINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00121 PTZ00121
MAEBL; Provisional
 1107-1592 2.54e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 2.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1107 QMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAeSEKQS 1186
Cdd:PTZ00121  1288 EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA-AEEKA 1366

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1187 LLLEERNKELISECNHLKERQYqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEvTSRYRINLEDETQDLKKKLGQI 1266
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAE--EKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEA 1443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1267 RnQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMD----KIEELQKNLLNANLSEDEK---EQLKKLMELK 1339
Cdd:PTZ00121  1444 K-KADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1340 QSLECNLDQEMKKNVELER--------EITGFKNLLKM-TRKKLNEYENGEFSFHGDLKTSQFEMDIQiNKLKHKIDDLT 1410
Cdd:PTZ00121  1523 KADEAKKAEEAKKADEAKKaeekkkadELKKAEELKKAeEKKKAEEAKKAEEDKNMALRKAEEAKKAE-EARIEEVMKLY 1601

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1411 AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQE----IEERA 1486
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEdkkkAEEAK 1681

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1487 RQEIAEKLKEVNLFLQAQAASQenLEQFRENNFASMKSQMELRikdLESELSKIKTSQEDfNKTELEKYKQlylEELKVR 1566
Cdd:PTZ00121  1682 KAEEDEKKAAEALKKEAEEAKK--AEELKKKEAEEKKKAEELK---KAEEENKIKAEEAK-KEAEEDKKKA---EEAKKD 1752

                          490       500
                   ....*....|....*....|....*.
gi 2462517859 1567 KSLSSKLTKTNERLAEVNTKLLVEKQ 1592
Cdd:PTZ00121  1753 EEEKKKIAHLKKEEEKKAEEIRKEKE 1778
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 750-1410 2.60e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.74  E-value: 2.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  750 TVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEV 829
Cdd:TIGR00606  397 TLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILEL 476

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  830 KQQLELSLQTL---------------EMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIemaqK 894
Cdd:TIGR00606  477 DQELRKAERELskaeknsltetlkkeVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQI----R 552

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  895 KMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQnqekekkcFEDLKIVKEKNEDLQKTIKQNEETLTQTISQY 974
Cdd:TIGR00606  553 KIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDR--------LAKLNKELASLEQNKNHINNELESKEEQLSSY 624

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  975 NGRL----SVLTAENAMLNSKLENEKQSKER--LEAEVESYHSRLAAAIH---------DRD-QSETSKRELELAFQRAR 1038
Cdd:TIGR00606  625 EDKLfdvcGSQDEESDLERLKEEIEKSSKQRamLAGATAVYSQFITQLTDenqsccpvcQRVfQTEAELQEFISDLQSKL 704

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1039 DECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1118
Cdd:TIGR00606  705 RLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESA 784

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1119 QV------KVNKYIGKQESVEERLSQLQSEN-----MLLRQQLDDAHNKADNKEKTVIniqdQFHAIVQKLQAESEKQSL 1187
Cdd:TIGR00606  785 KVcltdvtIMERFQMELKDVERKIAQQAAKLqgsdlDRTVQQVNQEKQEKQHELDTVV----SKIELNRKLIQDQQEQIQ 860

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1188 LLEERNKELISECNHLKE---RQYQYENEKAEREVVVRQLQQELAD---------TLKKQSMSEASLEVTSRYRIN--LE 1253
Cdd:TIGR00606  861 HLKSKTNELKSEKLQIGTnlqRRQQFEEQLVELSTEVQSLIREIKDakeqdspleTFLEKDQQEKEELISSKETSNkkAQ 940

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1254 DETQDLKKKLGQ-------IRNQLQEAQDRH--------TEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKN 1318
Cdd:TIGR00606  941 DKVNDIKEKVKNihgymkdIENKIQDGKDDYlkqketelNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDN 1020

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1319 LLNANLSEDEKEQLKKLME-LKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQF---- 1393
Cdd:TIGR00606 1021 LTLRKRENELKEVEEELKQhLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFrdae 1100

                          730       740
                   ....*....|....*....|.
gi 2462517859 1394 ----EMDIQINKLKHKIDDLT 1410
Cdd:TIGR00606 1101 ekyrEMMIVMRTTELVNKDLD 1121
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 812-1603 3.05e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.36  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  812 IREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERND----AQRQLSREQNARMLQ------------ 875
Cdd:TIGR00606  222 IRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEikalKSRKKQMEKDNSELElkmekvfqgtde 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  876 --DGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEK--------------- 938
Cdd:TIGR00606  302 qlNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARdsliqslatrleldg 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  939 -EKKCFEDLKI------VKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEkqsKERLEAEVEsyhs 1011
Cdd:TIGR00606  382 fERGPFSERQIknfhtlVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELK---KEILEKKQE---- 454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1012 RLAAAIHDRDQSETSKR---ELELAFQRARDECSRLQDKMNfdvsnlkdnneilSQQLFKTESKLNSLEIEFHHTRDALR 1088
Cdd:TIGR00606  455 ELKFVIKELQQLEGSSDrilELDQELRKAERELSKAEKNSL-------------TETLKKEVKSLQNEKADLDRKLRKLD 521

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1089 EKTLGLERVQKDLSQTQCQMKEMEQKYQneQVKVNKYIGKQESVEerlsqlQSENMLLRQQLDDAHNKADNKektvINIQ 1168
Cdd:TIGR00606  522 QEMEQLNHHTTTRTQMEMLTKDKMDKDE--QIRKIKSRHSDELTS------LLGYFPNKKQLEDWLHSKSKE----INQT 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1169 DQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAErEVVVRQLQQELADTLKKQSMSEASLEVTSRY 1248
Cdd:TIGR00606  590 RDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDE-ESDLERLKEEIEKSSKQRAMLAGATAVYSQF 668

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1249 RINLEDETQD---LKKKLGQIRNQLQEAQDRHTEAVRCA----EKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLln 1321
Cdd:TIGR00606  669 ITQLTDENQSccpVCQRVFQTEAELQEFISDLQSKLRLApdklKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEI-- 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1322 ANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELERE---------ITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQ 1392
Cdd:TIGR00606  747 PELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAkvcltdvtiMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQ 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1393 F-----EMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIER 1467
Cdd:TIGR00606  827 VnqekqEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKD 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1468 NMVELGQVKQYKQEIEERARQEIAEK---LKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQ 1544
Cdd:TIGR00606  907 AKEQDSPLETFLEKDQQEKEELISSKetsNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQL 986

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517859 1545 EdfnktELEKYKQLYLEELKVRKSlSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT 1603
Cdd:TIGR00606  987 E-----ECEKHQEKINEDMRLMRQ-DIDTQKIQERWLQDNLTLRKRENELKEVEEELKQ 1039
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 764-1461 3.31e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 51.94  E-value: 3.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  764 QRELSETKEIKSQLEHQkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEME 843
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNK----EKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  844 LRTVKSNLNQVVQERNDAQRQLsreQNARMLQDGILTNHLSKQKEIEmaqkKMNSENSHSHEEEKDLSHKNSMLQEEIAM 923
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQK---KENKKNIDKFLTEIKKKEKELE----KLNNKYNDLKKQKEELENELNLLEKEKLN 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  924 LRLEIDTIKNQNQEKEKKCFeDLKIVKEKNEDLQKTI---KQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKE 1000
Cdd:TIGR04523  185 IQKNIDKIKNKLLKLELLLS-NLKKKIQKNKSLESQIselKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQN 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1001 RLEaevesyhSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLkdnneiLSQQLFKTESKLNSLEIEF 1080
Cdd:TIGR04523  264 KIK-------KQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKE------LKSELKNQEKKLEEIQNQI 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNK 1160
Cdd:TIGR04523  331 SQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQK 410

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1161 EKTVINIQDQFHAIVQKLQAESEKQSLL------LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1234
Cdd:TIGR04523  411 DEQIKKLQQEKELLEKEIERLKETIIKNnseikdLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKE 490

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1235 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKL--EKDNAKLKVTVKKQMDKI 1312
Cdd:TIGR04523  491 LKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDdfELKKENLEKEIDEKNKEI 570

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1313 EEL---QKNLLNANLS--------EDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGE 1381
Cdd:TIGR04523  571 EELkqtQKSLKKKQEEkqelidqkEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQI 650

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1382 FSFHGDLKTSQFEMDIQINKLKHKIDDLT-------AELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKL 1454
Cdd:TIGR04523  651 KETIKEIRNKWPEIIKKIKESKTKIDDIIelmkdwlKELSLHYKKYITRMIRIKDLPKLEEKYKEIEKELKKLDEFSKEL 730


                   ....*..
gi 2462517859 1455 EQEVINL 1461
Cdd:TIGR04523  731 ENIIKNF 737
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-237 4.28e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 4.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   56 AGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQ------------- 122
Cdd:PHA02874    11 SGDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKigahdiikllidn 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  123 ----------CQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQ 192
Cdd:PHA02874    91 gvdtsilpipCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517859  193 QMVEFLIKKKANVNAVD-KLESSHQLISEYKEERIPKHSSQNSNSV 237
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDnNGESPLHNAAEYGDYACIKLLIDHGNHI 216
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 814-1358 5.29e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 51.29  E-value: 5.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  814 EQLRRKEEQYR--KEVEVKQQLELSLQTLEME---------------LRT-------VKSNLNQVVQERNDAQRQLSREQ 869
Cdd:pfam07111   73 QELRRLEEEVRllRETSLQQKMRLEAQAMELDalavaekagqaeaegLRAalagaemVRKNLEEGSQRELEEIQRLHQEQ 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  870 NARMLQ--DGILTNHLSKQKEIEmaqKKMNSENSHSHEEEKDLshknSMLQEEIAMLRLEIDTIKnQNQEKEKKCFEDLK 947
Cdd:pfam07111  153 LSSLTQahEEALSSLTSKAEGLE---KSLNSLETKRAGEAKQL----AEAQKEAELLRKQLSKTQ-EELEAQVTLVESLR 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  948 -----------------IVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAE----- 1005
Cdd:pfam07111  225 kyvgeqvppevhsqtweLERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEfpkkc 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1006 ---VESYHSRLAAAIHDRDQSETSKRElelAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKL-------NS 1075
Cdd:pfam07111  305 rslLNRWREKVFALMVQLKAQDLEHRD---SVKQLRGQVAELQEQ----VTSQSQEQAILQRALQDKAAEVevermsaKG 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1076 LEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQlqsenmllrqqlddahn 1155
Cdd:pfam07111  378 LQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSY----------------- 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1156 kADNKEKTVINIQDQFHAIVQkLQAESEKQSLLLEERNKELISECNHLKERQYQYEnekAEREVVVRQLQQELAdtlKKQ 1235
Cdd:pfam07111  441 -AVRKVHTIKGLMARKVALAQ-LRQESCPPPPPAPPVDADLSLELEQLREERNRLD---AELQLSAHLIQQEVG---RAR 512

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1236 SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA--------EKMQDHKQKLEKDNAKLKVTVKK 1307
Cdd:pfam07111  513 EQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAaslrqeltQQQEIYGQALQEKVAEVETRLRE 592

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462517859 1308 QMDKIEElqknllnaNLSEDEKEQLKKLMELKQsLECNLDQEMKKNVELER 1358
Cdd:pfam07111  593 QLSDTKR--------RLNEARREQAKAVVSLRQ-IQHRATQEKERNQELRR 634
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 82-202 6.16e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.17  E-value: 6.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   82 TALHLACANGHPEVVTLLVDRKCQLN------VCDNENRTALMK--------AVQCQEEKCATILLEHGADPNLADVHGN 147
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517859  148 TALHYAVYNEDISVATK----LLLYDANIEA------KNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd22192    171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKR 235
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1013-1276 7.02e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 7.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1013 LAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTL 1092
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKE----EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1093 GLERVQKDLSQTQCQMKEMEQKYQNeqvkvnkyIGKQESVEERLSQLQSENMLLRQQLDDAHNKADnkektviniQDQFH 1172
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYR--------LGRQPPLALLLSPEDFLDAVRRLQYLKYLAPAR---------REQAE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1173 AIVQKLQAESEKQSLLLEERnKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSmseaslevtsryriNL 1252
Cdd:COG4942    154 ELRADLAELAALRAELEAER-AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELA--------------EL 218

                          250       260
                   ....*....|....*....|....
gi 2462517859 1253 EDETQDLKKKLGQIRNQLQEAQDR 1276
Cdd:COG4942    219 QQEAEELEALIARLEAEAAAAAER 242
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1261-1595 8.63e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.83  E-value: 8.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1261 KKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLKKLMELKQ 1340
Cdd:PRK03918   165 KNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKL---EKEVKELEELKEEIE 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1341 SLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhGDLKTSQFEMD--IQINKLKHKIDDLTAELETAGS 1418
Cdd:PRK03918   242 ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV----KELKELKEKAEeyIKLSEFYEEYLDELREIEKRLS 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1419 KclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELGQVKQYKQEIEERARQEIAEKLK 1495
Cdd:PRK03918   318 R---LEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHelyEEAKAKKEELERLKKRLTGLTPEKLEKELE 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1496 EVNlflQAQAASQENLEQFREnnfasMKSQMELRIKDLESELSKIKTSQ-----------EDFNKTELEKYKQLYLEELK 1564
Cdd:PRK03918   395 ELE---KAKEEIEEEISKITA-----RIGELKKEIKELKKAIEELKKAKgkcpvcgreltEEHRKELLEEYTAELKRIEK 466

                          330       340       350
                   ....*....|....*....|....*....|.
gi 2462517859 1565 VRKSLSSKLTKTNERLAEVNTKLLVEKQQSR 1595
Cdd:PRK03918   467 ELKEIEEKERKLRKELRELEKVLKKESELIK 497
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 785-1016 8.73e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 8.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  785 ERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYrkevevkQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQ 864
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRI-------AALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  865 LSREQN--ARMLQDgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKD-LSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKK 941
Cdd:COG4942     99 LEAQKEelAELLRA------LYRLGRQPPLALLLSPEDFLDAVRRLQyLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517859  942 cFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAA 1016
Cdd:COG4942    173 -RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 721-1340 9.55e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 50.50  E-value: 9.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  721 DSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEW---EREL--------- 788
Cdd:pfam15921  208 DSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQlisEHEVeitglteka 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  789 -------CSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEV-EVKQQLELSLQTLEMELRTVKSNLNQVVQERNd 860
Cdd:pfam15921  288 ssarsqaNSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELrEAKRMYEDKIEELEKQLVLANSELTEARTERD- 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  861 aqrQLSREQnarmlqdGILTNHLSKqkeIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDT---------- 930
Cdd:pfam15921  367 ---QFSQES-------GNLDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlea 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  931 -IKNQNQEKEKKCFEDLKIVKEKNEDLQKT------IKQNEETLTQTISQYNG-RLSVLTAENAM--LNSKLENEKQSKE 1000
Cdd:pfam15921  434 lLKAMKSECQGQMERQMAAIQGKNESLEKVssltaqLESTKEMLRKVVEELTAkKMTLESSERTVsdLTASLQEKERAIE 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1001 RLEAEVESYHSRLAAAIHDRDQSETSKRELelafQRARDECSRLQDKMNFD---VSNLKDNNEILSQQLFKTESKLNSLE 1077
Cdd:pfam15921  514 ATNAEITKLRSRVDLKLQELQHLKNEGDHL----RNVQTECEALKLQMAEKdkvIEILRQQIENMTQLVGQHGRTAGAMQ 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1078 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIgkqESVEERLSQLQSenmlLRQQLDDAHNKA 1157
Cdd:pfam15921  590 VEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLV---NAGSERLRAVKD----IKQERDQLLNEV 662

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1158 DNKEKTVINIQDQFHAIVQKLQAESEKQSLL---LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKK 1234
Cdd:pfam15921  663 KTSRNELNSLSEDYEVLKRNFRNKSEEMETTtnkLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1235 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEE 1314
Cdd:pfam15921  743 IDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAE 822

                          650       660
                   ....*....|....*....|....*.
gi 2462517859 1315 LQkNLLNANLSEDEKEQLKKLMELKQ 1340
Cdd:pfam15921  823 CQ-DIIQRQEQESVRLKLQHTLDVKE 847
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 743-969 1.02e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 1.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  743 KNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQ 822
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE 874

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  823 YRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLS--REQNARM-LQDGILTNHLSKQKEIEMAQKKMNSE 899
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEelREKLAQLeLRLEGLEVRIDNLQERLSEEYSLTLE 954

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517859  900 NSHSHEEEKDLSHKNsmLQEEIAMLRLEIDTIKNQNQ------EKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQ 969
Cdd:TIGR02168  955 EAEALENKIEDDEEE--ARRRLKRLENKIKELGPVNLaaieeyEELKERYDFL---TAQKEDLTEAKETLEEAIEE 1025
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 752-1343 1.07e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  752 KIKKMEDKVNVLQRELSETKEIKSQLehqkvewERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQ 831
Cdd:TIGR04523   97 KINKLNSDLSKINSEIKNDKEQKNKL-------EVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKE 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  832 QLELSLQTLEMELRTVKSNLNQVVQERNdaqrqlsreqnarmlqdgILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLS 911
Cdd:TIGR04523  170 ELENELNLLEKEKLNIQKNIDKIKNKLL------------------KLELLLSNLKKKIQKNKSLESQISELKKQNNQLK 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  912 HKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEEtLTQTISQYNGRLSVLTAE-----NA 986
Cdd:TIGR04523  232 DNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKE-LEKQLNQLKSEISDLNNQkeqdwNK 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  987 MLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKmnfdVSNLKDNNEILSQQL 1066
Cdd:TIGR04523  311 ELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNE----IEKLKKENQSYKQEI 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1067 FKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLL 1146
Cdd:TIGR04523  387 KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESL 466

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1147 RQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSlLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQ 1226
Cdd:TIGR04523  467 ETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK-ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLED 545

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1227 EL---ADTLKKQsmseaslevtsryriNLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKV 1303
Cdd:TIGR04523  546 ELnkdDFELKKE---------------NLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEK 610

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 2462517859 1304 TVKKQMDKIEELQKNllNANLSEDEKEQLKKLMELKQSLE 1343
Cdd:TIGR04523  611 KISSLEKELEKAKKE--NEKLSSIIKNIKSKKNKLKQEVK 648
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 82-202 1.29e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.08  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   82 TALHLACANGHPEVVTLLVDRKCQLNV---CD-------------NENRTALMKAVQcqEEKCATILLEHGADPNLADVH 145
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGASVPAracGDffvksqgvdsfyhGESPLNAAACLG--SPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462517859  146 GNTALHYAVYNEDISVATK---------LLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:TIGR00870  208 GNTLLHLLVMENEFKAEYEelscqmynfALSLLDKLrdskeleVILNHQGLTPLKLAAKEGRIVLFRLKLAIK 280
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-209 1.35e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 1.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   41 HVRDRDLGK-IHKAASAGNVAKVQQILLLRKNgLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMK 119
Cdd:PHA02874   118 NIKDAELKTfLHYAIKKGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  120 AVQCQEEKCATILLEHGADPNLADVHGNTALHYAV-YNEDisvATKLLLYDANIEAKNKDDLTPLLLAVSGK-KQQMVEF 197
Cdd:PHA02874   197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIiHNRS---AIELLINNASINDQDIDGSTPLHHAINPPcDIDIIDI 273

                          170
                   ....*....|..
gi 2462517859  198 LIKKKANVNAVD 209
Cdd:PHA02874   274 LLYHKADISIKD 285
Ank_4 pfam13637
Ankyrin repeats (many copies);
146-199 1.62e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 1.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517859  146 GNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLI 199
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-179 2.09e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 2.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   51 HKAASAGNVAKvqQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLlvdrkcqlnvcdnenrtalmkavqcqeekcat 130
Cdd:PTZ00322    88 QLAASGDAVGA--RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRV-------------------------------- 133

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462517859  131 iLLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLY---DANIEAKNKDD 179
Cdd:PTZ00322   134 -LLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqcHFELGANAKPD 184
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
814-1298 2.54e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.00  E-value: 2.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  814 EQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDgiLTNHL-SKQKEIEMA 892
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA--LEAELaELPERLEEL 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  893 QKKMnsenshshEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTIS 972
Cdd:COG4717    152 EERL--------EELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDL---AEELEELQQRLAELEEELEEAQE 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  973 QYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESyhSRLAAAIHDRDQSETSKRELELAFQRA--------RDECSRL 1044
Cdd:COG4717    221 ELEELEEELEQLENELEAAALEERLKEARLLLLIAA--ALLALLGLGGSLLSLILTIAGVLFLVLgllallflLLAREKA 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1045 QDKMNFDVSNLKDNNEILSQQlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNK 1124
Cdd:COG4717    299 SLGKEAEELQALPALEELEEE--ELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALL 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1125 YIGKQESVEErlsqlqsenmlLRQQLdDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLlleernkelisecNHLK 1204
Cdd:COG4717    377 AEAGVEDEEE-----------LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALDE-------------EELE 431

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1205 ERQYQYENEKAEREVVVRQLQQELADTlkkqsmsEASLEVTSRyrinlEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCA 1284
Cdd:COG4717    432 EELEELEEELEELEEELEELREELAEL-------EAELEQLEE-----DGELAELLQELEELKAELRELAEEWAALKLAL 499

                          490
                   ....*....|....
gi 2462517859 1285 EKMQDHKQKLEKDN 1298
Cdd:COG4717    500 ELLEEAREEYREER 513
PTZ00121 PTZ00121
MAEBL; Provisional
 737-1432 3.28e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 3.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  737 RLLELKKNHCELLTVKIKKMEDkVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYekiREQL 816
Cdd:PTZ00121  1213 KAEEARKAEDAKKAEAVKKAEE-AKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK---KAEE 1288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  817 RRKEEQYRKEVEVKQQLELSLQTleMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKM 896
Cdd:PTZ00121  1289 KKKADEAKKAEEKKKADEAKKKA--EEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKA 1366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  897 NSENSHSHEEEKDLSHKNSMLQEeiamlRLEIDTIKNQNQEKEKKCfEDLKIVKEKNEDLQKTIKQNEEtltqtisqyng 976
Cdd:PTZ00121  1367 EAAEKKKEEAKKKADAAKKKAEE-----KKKADEAKKKAEEDKKKA-DELKKAAAAKKKADEAKKKAEE----------- 1429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  977 rlsVLTAENAmlNSKLENEKQSKE-RLEAEVESYHSRLAAAIHDRDQSETSKRELELAfqRARDECSRLQDKMNFDVSNL 1055
Cdd:PTZ00121  1430 ---KKKADEA--KKKAEEAKKADEaKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA--KKADEAKKKAEEAKKKADEA 1502

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1056 KDnneilsqqlfKTESKLNSLEIEFHHTRDALREKTLGLERVQKDlsqtqcQMKEMEQKYQNEQVKVNKYIGKQES---V 1132
Cdd:PTZ00121  1503 KK----------AAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD------EAKKAEEKKKADELKKAEELKKAEEkkkA 1566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1133 EERLSQLQSENMLLRQQlddahNKADNKEKTVINIQDQFHAIVQKLQAESEKQSllLEERNK-ELISECNHLKERQYQYE 1211
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKA-----EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA--EEAKIKaEELKKAEEEKKKVEQLK 1639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1212 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAqdRHTEAVRCAEKMQDHK 1291
Cdd:PTZ00121  1640 KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEA--KKAEELKKKEAEEKKK 1717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1292 -QKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMT 1370
Cdd:PTZ00121  1718 aEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517859 1371 RKKLNEYENGEFSFHGDLKTSQFemdiqINKLKHKIDDLTAELetagskclhLDTKNQILQE 1432
Cdd:PTZ00121  1798 KKIKDIFDNFANIIEGGKEGNLV-----INDSKEMEDSAIKEV---------ADSKNMQLEE 1845
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1303-1577 5.60e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.00  E-value: 5.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1303 VTVKKQMDK-IEELQKnlLNA----NLSEDEK-EQLKKLMELKQSLECNLDQeMKKNVELEReiTGFKNLLKMTRKKLNE 1376
Cdd:PRK05771    12 VTLKSYKDEvLEALHE--LGVvhieDLKEELSnERLRKLRSLLTKLSEALDK-LRSYLPKLN--PLREEKKKVSVKSLEE 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1377 YENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAgSKCLHLDtknqILQEELLSMKTVQKKCEKLQKNKKKLEQ 1456
Cdd:PRK05771    87 LIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFD----LDLSLLLGFKYVSVFVGTVPEDKLEELK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1457 EVINLRSHIErnmvelgqVKQYKQE------IEERARQEIAEKLKEVNLflqaqaasqENLEQFRENNFASMKSQMELRI 1530
Cdd:PRK05771   162 LESDVENVEY--------ISTDKGYvyvvvvVLKELSDEVEEELKKLGF---------ERLELEEEGTPSELIREIKEEL 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1531 KDLESELSKIKTSQEDFNKtELEKYKQLYLEEL---KVRKSLSSKLTKTN 1577
Cdd:PRK05771   225 EEIEKERESLLEELKELAK-KYLEELLALYEYLeieLERAEALSKFLKTD 273
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1394-1567 1.02e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.69  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1394 EMDIQINKLKHKIDDLTAELEtagskclHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELG 1473
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELA-------ELEDELAALEARL---EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1474 QVKQYKQ------EIE--ERARQEIAEKLKEVNLFLQAQAASQENLEQF---RENNFASMKSQMELRIKDLESELSKIKT 1542
Cdd:COG1579     84 NVRNNKEyealqkEIEslKRRISDLEDEILELMERIEELEEELAELEAElaeLEAELEEKKAELDEELAELEAELEELEA 163

                          170       180
                   ....*....|....*....|....*
gi 2462517859 1543 SQEDFNKTELEKYKQLYlEELKVRK 1567
Cdd:COG1579    164 EREELAAKIPPELLALY-ERIRKRK 187
Ank_5 pfam13857
Ankyrin repeats (many copies);
98-153 1.24e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.24e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517859   98 LLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYA 153
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1222-1434 1.27e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1222 RQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKL 1301
Cdd:COG4942     23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1302 KVTVKKQMDKIEEL-QKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENG 1380
Cdd:COG4942    103 KEELAELLRALYRLgRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462517859 1381 EFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEEL 1434
Cdd:COG4942    183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1235-1609 1.43e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.66  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1235 QSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQKLEKDNAKLKVTVKKQMDKIEE 1314
Cdd:pfam17380  247 EDVTTMTPEYTVRYNGQTMTENEFLNQLLHIVQHQKAVSERQQQEKF---EKMEQERLRQEKEEKAREVERRRKLEEAEK 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1315 LQKNLLN---ANLSEDEKEQLKKLMELKQSLECNLDQEMK--KNVELEREITGFKNL--LKMTRKKLNEYENGEFSFHGD 1387
Cdd:pfam17380  324 ARQAEMDrqaAIYAEQERMAMERERELERIRQEERKRELEriRQEEIAMEISRMRELerLQMERQQKNERVRQELEAARK 403

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1388 LKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLhldtknQILQEELlsmktvQKKCEKLQKNKKKLEQEVINLRSHIE- 1466
Cdd:pfam17380  404 VKILEEERQRKIQQQKVEMEQIRAEQEEARQREV------RRLEEER------AREMERVRLEEQERQQQVERLRQQEEe 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1467 --RNMVELGQVKQYKQEIEERARQEIAEKLKEvnlflQAQAASQEnleqfrENNFASMKSQMELRIKDLESELSKIKTSQ 1544
Cdd:pfam17380  472 rkRKKLELEKEKRDRKRAEEQRRKILEKELEE-----RKQAMIEE------ERKRKLLEKEMEERQKAIYEEERRREAEE 540

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517859 1545 EDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTT-RPVMEP 1609
Cdd:pfam17380  541 ERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTPITTiKPIYRP 606
PRK11281 PRK11281
mechanosensitive channel MscK;
949-1153 1.47e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.83  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  949 VKEKNEDLQKTIKQneetLTQTISQYNGRLSVLTAEN-------------AMLNSKLENEKQSKERLEAEVESYHSRLAA 1015
Cdd:PRK11281    78 QKEETEQLKQQLAQ----APAKLRQAQAELEALKDDNdeetretlstlslRQLESRLAQTLDQLQNAQNDLAEYNSQLVS 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1016 AihdRDQSETSKRELELAFQRArdecsrlqDKMNFDVSNLKDNNEILS---QQLFKTESKLNSLEIEFHHT--------- 1083
Cdd:PRK11281   154 L---QTQPERAQAALYANSQRL--------QQIRNLLKGGKVGGKALRpsqRVLLQAEQALLNAQNDLQRKslegntqlq 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1084 ------RDALREKTLGLERV---------QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ---------- 1138
Cdd:PRK11281   223 dllqkqRDYLTARIQRLEHQlqllqeainSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQrllkatekln 302

                          250
                   ....*....|....*.
gi 2462517859 1139 -LQSENMLLRQQLDDA 1153
Cdd:PRK11281   303 tLTQQNLRVKNWLDRL 318
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 1022-1567 1.66e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 46.27  E-value: 1.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1022 QSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDL 1101
Cdd:pfam05557   13 QLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1102 SQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQfhaivQKLQAE 1181
Cdd:pfam05557   93 NEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ-----QSSLAE 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1182 SEKQSLLLEERNKelisecnhlkerqyQYENEKAerevVVRQLQQELADTLKKQSMSEASLEVTSRYRIN------LEDE 1255
Cdd:pfam05557  168 AEQRIKELEFEIQ--------------SQEQDSE----IVKNSKSELARIPELEKELERLREHNKHLNENienkllLKEE 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1256 TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKqKLEKDNAKLKVTVKKQMDKIEELQ---------KNLLNANLSE 1326
Cdd:pfam05557  230 VEDLKRKLEREEKYREEAATLELEKEKLEQELQSWV-KLAQDTGLNLRSPEDLSRRIEQLQqreivlkeeNSSLTSSARQ 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1327 DEKEQLKKLMELKQSLECNLDQEM-------------KKNVELEREITGFKNLLKMTRKKLNEYENGEfsfhgDLKTSQF 1393
Cdd:pfam05557  309 LEKARRELEQELAQYLKKIEDLNKklkrhkalvrrlqRRVLLLTKERDGYRAILESYDKELTMSNYSP-----QLLERIE 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1394 EMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTvqkkcEKLQKNKKKLEQEVINLRSHIERNMVELG 1473
Cdd:pfam05557  384 EAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQ-----QESLADPSYSKEEVDSLRRKLETLELERQ 458

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1474 QVKQYKQEIE-ERARQEIAEKLKEV---------NLFLQAQAASQENLEQFRENNfASMKSQMELRIKDLESELSKIKTS 1543
Cdd:pfam05557  459 RLREQKNELEmELERRCLQGDYDPKktkvlhlsmNPAAEAYQQRKNQLEKLQAEI-ERLKRLLKKLEDDLEQVLRLPETT 537

                          570       580
                   ....*....|....*....|....
gi 2462517859 1544 QEDFNKTELEKYKQLYLEELKVRK 1567
Cdd:pfam05557  538 STMNFKEVLDLRKELESAELKNQR 561
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1113-1376 1.68e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.55  E-value: 1.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1113 QKYQNEQVKVnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKadnkektviniqdqfhaiVQKLQAESekQSLLLEER 1192
Cdd:COG3206    159 EAYLEQNLEL-----RREEARKALEFLEEQLPELRKELEEAEAA------------------LEEFRQKN--GLVDLSEE 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1193 NKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVtsryrinledetQDLKKKLGQIRNQLQE 1272
Cdd:COG3206    214 AKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVI------------QQLRAQLAELEAELAE 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1273 AQ----DRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEElQKNLLNANLsEDEKEQLKKLMELKQSLEcnldq 1348
Cdd:COG3206    282 LSarytPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQA-REASLQAQL-AQLEARLAELPELEAELR----- 354

                          250       260
                   ....*....|....*....|....*...
gi 2462517859 1349 emkknvELEREITGFKNLLKMTRKKLNE 1376
Cdd:COG3206    355 ------RLEREVEVARELYESLLQRLEE 376
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 81-202 1.84e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 46.03  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   81 RTALHLACANGHPEVVTLLVDRKC--QLNVCDNENRTA-----------LMKAVQCQEEKCATILLEHGADP---NLADV 144
Cdd:cd21882     74 QTALHIAIENRNLNLVRLLVENGAdvSARATGRFFRKSpgnlfyfgelpLSLAACTNQEEIVRLLLENGAQPaalEAQDS 153

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517859  145 HGNTALHYAVYNED---------ISVATKLLLYDANI-------EAKNKDDLTPLLLAVSGKKQQMVEFLIKKK 202
Cdd:cd21882    154 LGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLdptqqleEIPNHQGLTPLKLAAVEGKIVMFQHILQRE 227
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1130-1601 1.86e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 46.32  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1130 ESVEERLSQLQSENMLLRQQLDDAHNKADNKEktviniqdqfhAIVQKLQAES----------EKQSLLLEERNKELISE 1199
Cdd:pfam01576   85 EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEE-----------AARQKLQLEKvtteakikklEEDILLLEDQNSKLSKE 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1200 CNHLKERQYQYENEKAEREVVVRQLQQ----------ELADTLKKQSMSEASLEVTSRyriNLEDETQDLKKKLGQIRNQ 1269
Cdd:pfam01576  154 RKLLEERISEFTSNLAEEEEKAKSLSKlknkheamisDLEERLKKEEKGRQELEKAKR---KLEGESTDLQEQIAELQAQ 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1270 LQEAQdrhTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQ---MDKIEELQKNLLNANLSEDEKEQLKKlmELKQSLECnl 1346
Cdd:pfam01576  231 IAELR---AQLAKKEEELQAALARLEEETAQKNNALKKIrelEAQISELQEDLESERAARNKAEKQRR--DLGEELEA-- 303

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1347 dqeMKKNVELEREITGFKNLLKMTRkklnEYENGEFSFHGDLKTSQFEMDIQINKLKH--KIDDLTAELETAGSKCLHLD 1424
Cdd:pfam01576  304 ---LKTELEDTLDTTAAQQELRSKR----EQEVTELKKALEEETRSHEAQLQEMRQKHtqALEELTEQLEQAKRNKANLE 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1425 TKNQILQEELLS----MKTVQKKCEKLQKNKKKLEQEVINLRSHI---ERNMVELG------------------------ 1473
Cdd:pfam01576  377 KAKQALESENAElqaeLRTLQQAKQDSEHKRKKLEGQLQELQARLsesERQRAELAeklsklqselesvssllneaegkn 456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1474 --------QVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFAsmKSQMELRIKDLESELSKIKTSQE 1545
Cdd:pfam01576  457 iklskdvsSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEA--KRNVERQLSTLQAQLSDMKKKLE 534

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517859 1546 DFNKT-----ELEKYKQLYLEELKVR----KSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTL 1601
Cdd:pfam01576  535 EDAGTlealeEGKKRLQRELEALTQQleekAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNL 599
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 81-111 1.91e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.91e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462517859   81 RTALHLACA-NGHPEVVTLLVDRKCQLNVCDN 111
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 727-1008 2.41e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  727 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNAD 806
Cdd:TIGR02168  716 QLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLK 795

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  807 TLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR--------EQNARMLQDGI 878
Cdd:TIGR02168  796 EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeieelEELIEELESEL 875

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  879 ltNHLSKQK------------EIEMAQKKMNSENSHSHEEEKDLSHKNSML---QEEIAMLRLEIDTIKNQNQEKEKKCF 943
Cdd:TIGR02168  876 --EALLNERasleealallrsELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLQERLSEEYSLTL 953

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517859  944 EDLKIVKEKNEDLQKTIKQNEETLTQTI--------------SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVES 1008
Cdd:TIGR02168  954 EEAEALENKIEDDEEEARRRLKRLENKIkelgpvnlaaieeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE 1032
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1398-1558 4.30e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.20  E-value: 4.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1398 QINKLKHKIDDLTAELEtagSKCLHLDTKNQILQEELlsmKTVQKKCEKLQKNKKKLEQEVINLRSHIErnmvelgqvKQ 1477
Cdd:PRK00409   510 LIGEDKEKLNELIASLE---ELERELEQKAEEAEALL---KEAEKLKEELEEKKEKLQEEEDKLLEEAE---------KE 574

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1478 YKQEIEErARQEIAEKLKEVNLFLQAQAASQenleqfRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQ 1557
Cdd:PRK00409   575 AQQAIKE-AKKEADEIIKELRQLQKGGYASV------KAHELIEARKRLNKANEKKEKKKKKQKEKQEELKVGDEVKYLS 647


                   .
gi 2462517859 1558 L 1558
Cdd:PRK00409   648 L 648
PRK12704 PRK12704
phosphodiesterase; Provisional
 1209-1337 4.63e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.77  E-value: 4.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1209 QYENEKAEREVVVRQLQQElADTLKKQSMSEASLEVtSRYRINLEDETQDLKKKLGQIRNQLQ---EAQDRHTEAVrcaE 1285
Cdd:PRK12704    32 KIKEAEEEAKRILEEAKKE-AEAIKKEALLEAKEEI-HKLRNEFEKELRERRNELQKLEKRLLqkeENLDRKLELL---E 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517859 1286 KMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLN-----ANLSEDE-KEQLKKLME 1337
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQeleriSGLTAEEaKEILLEKVE 164
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 727-1271 5.09e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 44.71  E-value: 5.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  727 KIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEhQKVEWERElcslrfSLNQEEEKRRNAD 806
Cdd:pfam05483  223 KIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLE-EKTKLQDE------NLKELIEKKDHLT 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  807 TLYEKIREQLRRKEEqyrkevevkqqlelSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNAR-MLQDGILTNHLSK 885
Cdd:pfam05483  296 KELEDIKMSLQRSMS--------------TQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHsFVVTEFEATTCSL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  886 QKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAML---RLEIDTIKNQNQEKEKKCFEdlkivKEKNEDLQKTIKQ 962
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKnnkEVELEELKKILAEDEKLLDE-----KKQFEKIAEELKG 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  963 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELelaFQRARDECS 1042
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKEL---TQEASDMTL 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1043 RLQDKMNfDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREK----TLGLERVQKDLSQTQCQMKEMEQKYQNE 1118
Cdd:pfam05483  514 ELKKHQE-DIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKgdevKCKLDKSEENARSIEYEVLKKEKQMKIL 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1119 QVKVNKYIGKQESVEERLSQLQSENMLLR-------QQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAE------SEKQ 1185
Cdd:pfam05483  593 ENKCNNLKKQIENKNKNIEELHQENKALKkkgsaenKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEiedkkiSEEK 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1186 SLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-----EVTSRYRINLEDETQDLK 1260
Cdd:pfam05483  673 LLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLyknkeQEQSSAKAALEIELSNIK 752

                          570
                   ....*....|.
gi 2462517859 1261 KKLGQIRNQLQ 1271
Cdd:pfam05483  753 AELLSLKKQLE 763
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 80-108 7.46e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 7.46e-04
                           10        20
                   ....*....|....*....|....*....
gi 2462517859   80 NRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 79-108 8.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.34  E-value: 8.63e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517859    79 MNRTALHLACANGHPEVVTLLVDRKCQLNV 108
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
676-1280 8.68e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 8.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  676 NQIQSMDDVDDLTqssetasedcELphssYKNFML-------LIEQLgmecKDSVSLLK-----IQDAALSCERLLELKK 743
Cdd:COG4913    198 HKTQSFKPIGDLD----------DF----VREYMLeepdtfeAADAL----VEHFDDLEraheaLEDAREQIELLEPIRE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  744 NHcelltVKIKKMEDKVNVLQRELSETKEIKSQLEHQkvEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQY 823
Cdd:COG4913    260 LA-----ERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  824 RK-EVEVKQQLELSLQTLEMELRTVKSNLNQ-----------VVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEM 891
Cdd:COG4913    333 RGnGGDRLEQLEREIERLERELEERERRRARleallaalglpLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEA 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  892 AQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIdtiknqnQEKEKKCFEDLKI------VKEKNEDLQKTI----- 960
Cdd:COG4913    413 ALRDLRRELRELEAEIASLERRKSNIPARLLALRDAL-------AEALGLDEAELPFvgelieVRPEEERWRGAIervlg 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  961 ---------KQNEETLTQTISQYNGRLSVLTaenamlnSKLENEKQSKERLEAEVESYHSRLAAAIHD-RD--QSETSKR 1028
Cdd:COG4913    486 gfaltllvpPEHYAAALRWVNRLHLRGRLVY-------ERVRTGLPDPERPRLDPDSLAGKLDFKPHPfRAwlEAELGRR 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1029 ------ELELAFQRAR----DECsrlQDKMNFDVSNLKDNNEILSQQL--FKTESKLNSLEIEfhhtRDALREKtlgLER 1096
Cdd:COG4913    559 fdyvcvDSPEELRRHPraitRAG---QVKGNGTRHEKDDRRRIRSRYVlgFDNRAKLAALEAE----LAELEEE---LAE 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1097 VQKDLSQTQCQMKEMEQK---------YQNEQVKVnkyigkqESVEERLSQLQSEnmllRQQLDDAHNKadnkektVINI 1167
Cdd:COG4913    629 AEERLEALEAELDALQERrealqrlaeYSWDEIDV-------ASAEREIAELEAE----LERLDASSDD-------LAAL 690

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1168 QDQFHAIVQKLQaESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEaslEVTSR 1247
Cdd:COG4913    691 EEQLEELEAELE-ELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGD---AVERE 766

                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462517859 1248 YRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1280
Cdd:COG4913    767 LRENLEERIDALRARLNRAEEELERAMRAFNRE 799
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1254-1526 9.33e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 9.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1254 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLlnANLSEDEKEQLK 1333
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAEL--AELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1334 KLMELKQSLEcnldqemkknvelereitgfKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQ--INKLKHKIDDLTA 1411
Cdd:COG4942     98 ELEAQKEELA--------------------ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKylAPARREQAEELRA 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1412 ELETagskclhLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIA 1491
Cdd:COG4942    158 DLAE-------LAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2462517859 1492 EklkevnlfLQAQAASQEnlEQFRENNFASMKSQM 1526
Cdd:COG4942    231 R--------LEAEAAAAA--ERTPAAGFAALKGKL 255
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 758-984 9.85e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.89  E-value: 9.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  758 DKVNVLQRELSETKEIKSQLE----HQKV--EWERELCSLRFSLNQEEEKRRNadtlyekIREQLRRKE-EQyrKEVEVK 830
Cdd:PRK10929    45 EIVEALQSALNWLEERKGSLErakqYQQVidNFPKLSAELRQQLNNERDEPRS-------VPPNMSTDAlEQ--EILQVS 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  831 QQL-ELS--LQTLEMELRTVKSNLNQVVQERNDAQRQLSreQNARMLQdgILTNHLSKQKEIEMAQKKMNSENSHSHEEE 907
Cdd:PRK10929   116 SQLlEKSrqAQQEQDRAREISDSLSQLPQQQTEARRQLN--EIERRLQ--TLGTPNTPLAQAQLTALQAESAALKALVDE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  908 KDLSHKNSMLQEEIAMLRLEI----------------DTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTI----KQNEEtL 967
Cdd:PRK10929   192 LELAQLSANNRQELARLRSELakkrsqqldaylqalrNQLNSQRQREAERALESTELLAEQSGDLPKSIvaqfKINRE-L 270

                          250
                   ....*....|....*..
gi 2462517859  968 TQTISQYNGRLSVLTAE 984
Cdd:PRK10929   271 SQALNQQAQRMDLIASQ 287
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 786-1178 9.92e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 9.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  786 RELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQL 865
Cdd:TIGR02169  681 ERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSEL 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  866 srEQNARMLQDgiltnhlsKQKEIEMAQKKMNS-ENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIknqNQEKEKKCFE 944
Cdd:TIGR02169  761 --KELEARIEE--------LEEDLHKLEEALNDlEARLSHSRIPEIQAELSKLEEEVSRIEARLREI---EQKLNRLTLE 827

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  945 dlkivKEKNEDLQKTIKQNEETLTQTISQyngrlsvLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSE 1024
Cdd:TIGR02169  828 -----KEYLEKEIQELQEQRIDLKEQIKS-------IEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELE 895

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1025 TSKRELelafQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEfhhtrdalREKTLGLERVQKDLSQT 1104
Cdd:TIGR02169  896 AQLREL----ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI--------PEEELSLEDVQAELQRV 963

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1105 QCQMKEMEQkyqneqvkVN-KYIGKQESVEERLSQLQSENMLL---RQQLDDAHNKADNKEKTV-----INIQDQFHAIV 1175
Cdd:TIGR02169  964 EEEIRALEP--------VNmLAIQEYEEVLKRLDELKEKRAKLeeeRKAILERIEEYEKKKREVfmeafEAINENFNEIF 1035


                   ...
gi 2462517859 1176 QKL 1178
Cdd:TIGR02169 1036 AEL 1038
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1167-1587 1.03e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1167 IQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYenekaerevvvRQLQQELADTLKKQSMSEASLEVTS 1246
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEY-----------AELQEELEELEEELEELEAELEELR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1247 RYRINLEDETQ--DLKKKLGQIRNQLQEAQDRHTEAVrcaEKMQDHKQkLEKDNAKLKVTVKKQMDKIEELQKNLLNANL 1324
Cdd:COG4717    116 EELEKLEKLLQllPLYQELEALEAELAELPERLEELE---ERLEELRE-LEEELEELEAELAELQEELEELLEQLSLATE 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1325 SEDE--KEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKL 1402
Cdd:COG4717    192 EELQdlAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSL 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1403 KHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKK--LEQEVINLRSHIERNMVELGQVKQYKQ 1480
Cdd:COG4717    272 ILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEelLAALGLPPDLSPEELLELLDRIEELQE 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1481 EIEERARQEIAEKLKEVNLFLQA--QAASQENLEQFRE-----NNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELE 1553
Cdd:COG4717    352 LLREAEELEEELQLEELEQEIAAllAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELLGELEELLEALDEEELE 431

                          410       420       430
                   ....*....|....*....|....*....|....
gi 2462517859 1554 KYKQLYLEELkvrKSLSSKLTKTNERLAEVNTKL 1587
Cdd:COG4717    432 EELEELEEEL---EELEEELEELREELAELEAEL 462
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1000-1535 1.04e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.88  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1000 ERLEAEVESYHSRLAAAIHDRDQSETSKR--ELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTEsKLNSLE 1077
Cdd:PRK02224   179 ERVLSDQRGSLDQLKAQIEEKEEKDLHERlnGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERRE-ELETLE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1078 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKA 1157
Cdd:PRK02224   258 AEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAA 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1158 DNKEKtviniqdqfhaivqklQAESEKQSLL-LEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQS 1236
Cdd:PRK02224   338 QAHNE----------------EAESLREDADdLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1237 MSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA---------------------VRCAEKMQDHKQKLE 1295
Cdd:PRK02224   402 DAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAealleagkcpecgqpvegsphVETIEEDRERVEELE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1296 KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLN 1375
Cdd:PRK02224   482 AELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAA 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1376 E-YENGEFSFH--GDLKTSQFEMDIQINKLKhKIDDLTAELETAGSKCLHLDTKNQILQE-ELLSMKTVQKKCEKlqknK 1451
Cdd:PRK02224   562 EaEEEAEEAREevAELNSKLAELKERIESLE-RIRTLLAAIADAEDEIERLREKREALAElNDERRERLAEKRER----K 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1452 KKLEQEVINLRshIERNMVELGQVKQYKQEIEERARqEIAEKLKEVNLFLQAQAASQENLEQFRENnfasmKSQMELRIK 1531
Cdd:PRK02224   637 RELEAEFDEAR--IEEAREDKERAEEYLEQVEEKLD-ELREERDDLQAEIGAVENELEELEELRER-----REALENRVE 708


                   ....
gi 2462517859 1532 DLES 1535
Cdd:PRK02224   709 ALEA 712
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1129-1379 1.09e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.85  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1129 QESVEERLSQLQSENMLLR----QQLDDAHNKADNKEKTVINiqdqfhAIVQKLQAESEKQSLLLE----ERNKELISE- 1199
Cdd:COG3206     80 DSPLETQIEILKSRPVLERvvdkLNLDEDPLGEEASREAAIE------RLRKNLTVEPVKGSNVIEisytSPDPELAAAv 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1200 CNHLKE--RQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEvtsRYR-----INLEDETQDLKKKLGQIRNQLQE 1272
Cdd:COG3206    154 ANALAEayLEQNLELRREEARKALEFLEEQLPELRKELEEAEAALE---EFRqknglVDLSEEAKLLLQQLSELESQLAE 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1273 AQDRHTEAVRCAEKMQDHKQKLEKDNAKLK--VTVKKQMDKIEELQKNLlnANLSE---DEKEQLKKLMELKQSLECNLD 1347
Cdd:COG3206    231 ARAELAEAEARLAALRAQLGSGPDALPELLqsPVIQQLRAQLAELEAEL--AELSArytPNHPDVIALRAQIAALRAQLQ 308

                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462517859 1348 QEMKKN-VELEREITGFKNLLKMTRKKLNEYEN 1379
Cdd:COG3206    309 QEAQRIlASLEAELEALQAREASLQAQLAQLEA 341
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 145-177 1.35e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.35e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462517859  145 HGNTALHYAVYNE-DISVATKLLLYDANIEAKNK 177
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
752-1111 1.38e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  752 KIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTlyekiREQLRRKEEQYRkevevkq 831
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASA-----EREIAELEAELE------- 678

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  832 QLELS---LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARmlqdgiltnhlsKQKEIEMAQKKMNSENSHSHEEEK 908
Cdd:COG4913    679 RLDASsddLAALEEQLEELEAELEELEEELDELKGEIGRLEKEL------------EQAEEELDELQDRLEAAEDLARLE 746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  909 DLSHKNSMLQEEIAmlrleidtiknqnQEKEKKCFEDLkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAE---- 984
Cdd:COG4913    747 LRALLEERFAAALG-------------DAVERELRENL---EERIDALRARLNRAEEELERAMRAFNREWPAETADldad 810

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  985 -------NAMLNsKLENekqskERLEAevesYHSRLAAAIHdrDQSETSKRELELAFQRARDECSRlqdkmnfdvsNLKD 1057
Cdd:COG4913    811 leslpeyLALLD-RLEE-----DGLPE----YEERFKELLN--ENSIEFVADLLSKLRRAIREIKE----------RIDP 868

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462517859 1058 NNEILSQQLFKTESKLnSLEI------EFHHTRDALREKTLGLERVQKDLSQTQC-QMKEM 1111
Cdd:COG4913    869 LNDSLKRIPFGPGRYL-RLEArprpdpEVREFRQELRAVTSGASLFDEELSEARFaALKRL 928
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 75-203 1.44e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.02  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   75 DRDKMNRTALHLACANGhpEVVTLLVDRkcqlNVCDNENRTALMK----AVQC-----------QEEKCaTILLEHGADP 139
Cdd:PHA02736    12 EPDIEGENILHYLCRNG--GVTDLLAFK----NAISDENRYLVLEynrhGKQCvhivsnpdkadPQEKL-KLLMEWGADI 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462517859  140 NLAD-VHGNTALHYAVYNEDISVATKLLLY-DANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA 203
Cdd:PHA02736    85 NGKErVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1042-1516 1.69e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1042 SRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEI---EFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNE 1118
Cdd:COG4717     49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEkeeEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLL 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1119 QvkvnkYIGKQESVEERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKE 1195
Cdd:COG4717    129 P-----LYQELEALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1196 LISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEA-----------SLEVTSRYRINLEDE--------- 1255
Cdd:COG4717    204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEArlllliaaallALLGLGGSLLSLILTiagvlflvl 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1256 ------TQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEK 1329
Cdd:COG4717    284 gllallFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA---EELE 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1330 EQLKkLMELKQSLECNLDQemkKNVELEREItgfknllkmtRKKLNEYEngefsfhgdlktsqfemdiQINKLKHKIDDL 1409
Cdd:COG4717    361 EELQ-LEELEQEIAALLAE---AGVEDEEEL----------RAALEQAE-------------------EYQELKEELEEL 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1410 TAELEtagskclhldtknQILQEELLSMKTVQKkcEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEE----- 1484
Cdd:COG4717    408 EEQLE-------------ELLGELEELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEdgela 472

                          490       500       510
                   ....*....|....*....|....*....|....*
gi 2462517859 1485 RARQEIAEKLKEVNLFLQ---AQAASQENLEQFRE 1516
Cdd:COG4717    473 ELLQELEELKAELRELAEewaALKLALELLEEARE 507
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 1064-1206 1.70e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.15  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1064 QQLFKTESKLNSLEIEfhhtRDAL-REKTLG----LERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQ 1138
Cdd:COG0542    411 EELDELERRLEQLEIE----KEALkKEQDEAsferLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYGK 486

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462517859 1139 LQSenmlLRQQLDDAHNKADNKEKTVINI--QDQFHAIV--------QKLQaESEKQSLL-LEErnkelisecnHLKER 1206
Cdd:COG0542    487 IPE----LEKELAELEEELAELAPLLREEvtEEDIAEVVsrwtgipvGKLL-EGEREKLLnLEE----------ELHER 550
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1100-1280 1.74e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.51  E-value: 1.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1100 DLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1179
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1180 AESEKQSLL---------------------LEERNKELISEcnhLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMS 1238
Cdd:COG3883     97 RSGGSVSYLdvllgsesfsdfldrlsalskIADADADLLEE---LKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 2462517859 1239 EASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEA 1280
Cdd:COG3883    174 EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-215 1.87e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   79 MNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNED 158
Cdd:PHA02875     1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  159 ISVATKLLLYDANI-EAKNKDDLTPLLLAVSGKKQQMVEFLIKKKA--NVNAVDKLESSH 215
Cdd:PHA02875    81 VKAVEELLDLGKFAdDVFYKDGMTPLHLATILKKLDIMKLLIARGAdpDIPNTDKFSPLH 140
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 178-210 1.87e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462517859  178 DDLTPLLLAV-SGKKQQMVEFLIKKKANVNAVDK 210
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 918-1142 2.00e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.44  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  918 QEEIAMLRLEIDTIKNQNQEKEKKcfedlkivKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQ 997
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKE--------LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  998 SKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLE 1077
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELE 170

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462517859 1078 IEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSE 1142
Cdd:COG4942    171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
736-1174 2.01e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.13  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  736 ERLLELKKNHCELltVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQ 815
Cdd:PRK03918   273 KEIEELEEKVKEL--KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  816 LRRKEEqyrkevevkqqLELSLQTLEmELRTVKSNLNQVVQERNDaqrqLSREQNARMLQDgiltnhLSKQK-EIEMAQK 894
Cdd:PRK03918   351 EKRLEE-----------LEERHELYE-EAKAKKEELERLKKRLTG----LTPEKLEKELEE------LEKAKeEIEEEIS 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  895 KMNSENSHSHEEEKDLSHKNSMLQ-------------------EEIAMLRLEIDTIKNQNQEKEKKcFEDLKIVKEKNED 955
Cdd:PRK03918   409 KITARIGELKKEIKELKKAIEELKkakgkcpvcgrelteehrkELLEEYTAELKRIEKELKEIEEK-ERKLRKELRELEK 487

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  956 L---QKTIKQNEETLTQtISQYNGRLSVLTAENamLNSKLENEKQSKERLeAEVESYHSRLAAAIHDRDQSETSKRELEL 1032
Cdd:PRK03918   488 VlkkESELIKLKELAEQ-LKELEEKLKKYNLEE--LEKKAEEYEKLKEKL-IKLKGEIKSLKKELEKLEELKKKLAELEK 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1033 AFQRARDECSRLQDKM-NFDVSNLKDNNEILSQ---------QLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLS 1102
Cdd:PRK03918   564 KLDELEEELAELLKELeELGFESVEELEERLKElepfyneylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462517859 1103 QTQCQMKEMEQKYQNEqvkvnkyigKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAI 1174
Cdd:PRK03918   644 ELRKELEELEKKYSEE---------EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER 706
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
737-1191 2.16e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.83  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  737 RLLELKKNHCELLTVKIKKMEDKvnvlQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTL--YEKIRE 814
Cdd:COG4717     64 RKPELNLKELKELEEELKEAEEK----EEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYqeLEALEA 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  815 QLRRKEEQYRkevEVKQQLElSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQK 894
Cdd:COG4717    140 ELAELPERLE---ELEERLE-ELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEEL 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  895 KMNSENSHSHEEEKDLSHKNSMLQEE------------IAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQ 962
Cdd:COG4717    216 EEAQEELEELEEELEQLENELEAAALeerlkearllllIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAR 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  963 NEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELafQRARDECS 1042
Cdd:COG4717    296 EKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQL--EELEQEIA 373

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1043 RLQDKmnFDVSNLKDNNEILSQQlfkteSKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQC--QMKEMEQKYQNEQV 1120
Cdd:COG4717    374 ALLAE--AGVEDEEELRAALEQA-----EEYQELKEELEELEEQLEELLGELEELLEALDEEELeeELEELEEELEELEE 446

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462517859 1121 KVNKYIGKQESVEERLSQLQSENML--LRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ-AESEKQSLLLEE 1191
Cdd:COG4717    447 ELEELREELAELEAELEQLEEDGELaeLLQELEELKAELRELAEEWAALKLALELLEEAREeYREERLPPVLER 520
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1112-1331 2.28e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1112 EQKYQNEQVKVNKYIGKQESVEERLSQLQsenmllrQQLDDAHNKADNKEKTVINIQDQfhaiVQKLQAESEKQSLLLEE 1191
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQ-------AELEELNEEYNELQAELEALQAE----IDKLQAEIAEAEAEIEE 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1192 RNKELisecnhlKER-QYQYENEKA-----------------EREVVVRQLQQELADTLKKQSMSEASLEvtsRYRINLE 1253
Cdd:COG3883     84 RREEL-------GERaRALYRSGGSvsyldvllgsesfsdflDRLSALSKIADADADLLEELKADKAELE---AKKAELE 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462517859 1254 DETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQ 1331
Cdd:COG3883    154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1260-1592 2.62e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 42.53  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1260 KKKLGQIRNQLQEAQDRhteavrcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLS-------------- 1325
Cdd:pfam06160   85 KKALDEIEELLDDIEED-------IKQILEELDELLESEEKNREEVEELKDKYRELRKTLLANRFSygpaidelekqlae 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1326 -EDEKEQLKKLMELKQSLECN--LDQEMKKNVELEREITGFKNLLKMTRK----KLNEYENGefsfHGDLKTSQF----- 1393
Cdd:pfam06160  158 iEEEFSQFEELTESGDYLEARevLEKLEEETDALEELMEDIPPLYEELKTelpdQLEELKEG----YREMEEEGYalehl 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1394 EMDIQINKLKHKIDDLTAELETagskcLHLDT---KNQILQEELLSM-----------KTVQKKCEKLQKNKKKLEQEVI 1459
Cdd:pfam06160  234 NVDKEIQQLEEQLEENLALLEN-----LELDEaeeALEEIEERIDQLydllekevdakKYVEKNLPEIEDYLEHAEEQNK 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1460 NLRSHIER-------NMVELGQVKQYKQEIEerarqEIAEKLKEVnlflqaqaasqenLEQFRENNFASmkSQMELRIKD 1532
Cdd:pfam06160  309 ELKEELERvqqsytlNENELERVRGLEKQLE-----ELEKRYDEI-------------VERLEEKEVAY--SELQEELEE 368

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1533 LESELSKIKTSQEDFNktelEKYKQLYLEELKVRKslssKLTKTNERLAEVntKLLVEKQ 1592
Cdd:pfam06160  369 ILEQLEEIEEEQEEFK----ESLQSLRKDELEARE----KLDEFKLELREI--KRLVEKS 418
COG5022 COG5022
Myosin heavy chain [General function prediction only];
754-1380 2.83e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 42.76  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  754 KKMEDKVNVLQRELsETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNA---DTLYEKI---REQLRRKEEQYRKEV 827
Cdd:COG5022    813 RSYLACIIKLQKTI-KREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLlkkETIYLQSaqrVELAERQLQELKIDV 891

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  828 EVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQnARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEE 907
Cdd:COG5022    892 KSISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARL-KKLLNNIDLEEGPSIEYVKLPELNKLHEVESKLKETS 970

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  908 KDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKcfedlkivKEKNEDLQKTIKQNEETltqtisqyNGRLSVLTAENAM 987
Cdd:COG5022    971 EEYEDLLKKSTILVREGNKANSELKNFKKELAEL--------SKQYGALQESTKQLKEL--------PVEVAELQSASKI 1034

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  988 LNSKLENEKQSKErlEAEVESyhsrlaaaIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLF 1067
Cdd:COG5022   1035 ISSESTELSILKP--LQKLKG--------LLLLENNQLQARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEVT 1104

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1068 KTESKLNSLEIEF-----------HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQV---KVNKYIGKQESV- 1132
Cdd:COG5022   1105 NRNLVKPANVLQFivaqmiklnllQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpspPPFAALSEKRLYq 1184

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1133 ----EERLSQLQSENMLLRQQLD---DAHNKADNKEKTVINIQDQ---FHAIVQKLQAESEKQSLLLEER---NKELISE 1199
Cdd:COG5022   1185 salyDEKSKLSSSEVNDLKNELIalfSKIFSGWPRGDKLKKLISEgwvPTEYSTSLKGFNNLNKKFDTPAsmsNEKLLSL 1264

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1200 CNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQ-SMSEASLEVTSRYRINlEDETQDLKKKLGQIRNQLQEAQDRHT 1278
Cdd:COG5022   1265 LNSIDNLLSSYKLEEEVLPATINSLLQYINVGLFNAlRTKASSLRWKSATEVN-YNSEELDDWCREFEISDVDEELEELI 1343

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1279 EAVRCaekmqdhKQKLEKDNAKLKVTVkkqmdKIEELQKNLLNANLSEDEKEQLKklmelkqslECNLDQEMKKNV---- 1354
Cdd:COG5022   1344 QAVKV-------LQLLKDDLNKLDELL-----DACYSLNPAEIQNLKSRYDPADK---------ENNLPKEILKKIeall 1402

                          650       660
                   ....*....|....*....|....*....
gi 2462517859 1355 ---ELEREITGFKNLLKMTRKKLNEYENG 1380
Cdd:COG5022   1403 ikqELQLSLEGKDETEVHLSEIFSEEKSL 1431
PHA02946 PHA02946
ankyin-like protein; Provisional
 80-215 3.24e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   80 NRTALHLACA-NGHPE-VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNE 157
Cdd:PHA02946    37 NYHILHAYCGiKGLDErFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTD 116

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  158 D--ISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSH 215
Cdd:PHA02946   117 DevIERINLLVQYGAKINNSVDEEGCGPLLACTDPSERVFKKIMSIGFEARIVDKFGKNH 176
PRK11281 PRK11281
mechanosensitive channel MscK;
752-1110 3.26e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.21  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  752 KIKKMEDKVNVLQRELSETKEIKSQLEHQKveweRELCSLRFSLNQEEEKRRNADTLYEKIREQLrrkeeqyrkEVEVKQ 831
Cdd:PRK11281    50 KQKLLEAEDKLVQQDLEQTLALLDKIDRQK----EETEQLKQQLAQAPAKLRQAQAELEALKDDN---------DEETRE 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  832 QLE-LSLQTLEmelrtvkSNLNQVVQERNDAQRQLSrEQNARMlqdgiltnhLSKQKEIEMAQKKMNSENSHSHEEEKDL 910
Cdd:PRK11281   117 TLStLSLRQLE-------SRLAQTLDQLQNAQNDLA-EYNSQL---------VSLQTQPERAQAALYANSQRLQQIRNLL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  911 SH----KNSMLQEEIAMLRLEIDTIKNQNqekekkcfedlkivkekneDLQKTIKQNEETLTQTisqYNGRLSVLTAENA 986
Cdd:PRK11281   180 KGgkvgGKALRPSQRVLLQAEQALLNAQN-------------------DLQRKSLEGNTQLQDL---LQKQRDYLTARIQ 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  987 mlnsklenekqskeRLEAEVESyhsrLAAAIHDR--DQSETSKRELElafqrARDECSRLQDkmNFDVSNLKDNNEILSQ 1064
Cdd:PRK11281   238 --------------RLEHQLQL----LQEAINSKrlTLSEKTVQEAQ-----SQDEAARIQA--NPLVAQELEINLQLSQ 292

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517859 1065 QLFKTESKLNSLeiefhhTRDALREKTLgLERvqkdLSQTQCQMKE 1110
Cdd:PRK11281   293 RLLKATEKLNTL------TQQNLRVKNW-LDR----LTQSERNIKE 327
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-224 3.88e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 3.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   50 IHKAASAGNVAKVQQiLLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNEnrTALMKAVQCQEEKCA 129
Cdd:PHA02878    41 LHQAVEARNLDVVKS-LLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEIF 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  130 TILLEHGADPN--LADVHGNTALHYAVYNEDIsvaTKLLL-YDANIEAKNKDDL-TPLLLAVSGKKQQMVEFLIKKKANV 205
Cdd:PHA02878   118 KIILTNRYKNIqtIDLVYIDKKSKDDIIEAEI---TKLLLsYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANV 194

                          170       180
                   ....*....|....*....|.
gi 2462517859  206 NAVDKLESS--HQLISEYKEE 224
Cdd:PHA02878   195 NIPDKTNNSplHHAVKHYNKP 215
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 930-1555 4.00e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  930 TIKNQNQEKEKKCFEDL--KIVKEKN-----EDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERL 1002
Cdd:TIGR01612 1162 AISNDDPEEIEKKIENIvtKIDKKKNiydeiKKLLNEIAEIEKDKTSLEEVKGINLSYGKNLGKLFLEKIDEEKKKSEHM 1241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1003 EAEVESYhsrlaaaIHDRDQSETSKRELELAFQRARDecsrLQDKMN-FDVSNLKDNNE-ILSQQLFKTESKLNSLEIEF 1080
Cdd:TIGR01612 1242 IKAMEAY-------IEDLDEIKEKSPEIENEMGIEMD----IKAEMEtFNISHDDDKDHhIISKKHDENISDIREKSLKI 1310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1081 hhTRDALREKTLG--LERVQKDLSQTQCQMKEMEQkYQNEQ------VKVNKYIGKQESVEERLSQLQSENMLLRQQLDd 1152
Cdd:TIGR01612 1311 --IEDFSEESDINdiKKELQKNLLDAQKHNSDINL-YLNEIaniyniLKLNKIKKIIDEVKEYTKEIEENNKNIKDELD- 1386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1153 ahnkadNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQ----YENEKAEREVVVRQLQQ-E 1227
Cdd:TIGR01612 1387 ------KSEKLIKKIKDDINLEECKSKIESTLDDKDIDECIKKIKELKNHILSEESNidtyFKNADENNENVLLLFKNiE 1460

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1228 LADTLKKQSMSEASLEVTSRYRINLedetqdlkkklgqirNQLQEAQDRhteavrcaekmqDHKQKLEKDNAKlkvtvkK 1307
Cdd:TIGR01612 1461 MADNKSQHILKIKKDNATNDHDFNI---------------NELKEHIDK------------SKGCKDEADKNA------K 1507

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1308 QMDKIEELQKNLlnanlSEDEKEQLKKLMELkqSLECNLDQEMKKNVELEREITGFKNLLKM----TRKKLNEYENGEFS 1383
Cdd:TIGR01612 1508 AIEKNKELFEQY-----KKDVTELLNKYSAL--AIKNKFAKTKKDSEIIIKEIKDAHKKFILeaekSEQKIKEIKKEKFR 1580

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1384 FHGDL----KTSQFEMDIQ------------INKLKHKIDDLTAELETAGSK--CLHLDTKNQILQEELLSMKTVQKKCE 1445
Cdd:TIGR01612 1581 IEDDAakndKSNKAAIDIQlslenfenkflkISDIKKKINDCLKETESIEKKisSFSIDSQDTELKENGDNLNSLQEFLE 1660

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1446 KLQKNKKKLE---QEVINLRSHIERNMVElgqVKQYKQEIEerarQEIAEKLKEVNLflqaqaASQENLEqfrennfaSM 1522
Cdd:TIGR01612 1661 SLKDQKKNIEdkkKELDELDSEIEKIEID---VDQHKKNYE----IGIIEKIKEIAI------ANKEEIE--------SI 1719

                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462517859 1523 KSQMELRIKDLESELSKIKTSQEDFNKtELEKY 1555
Cdd:TIGR01612 1720 KELIEPTIENLISSFNTNDLEGIDPNE-KLEEY 1751
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 145-174 4.28e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.28e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462517859   145 HGNTALHYAVYNEDISVATKLLLYDANIEA 174
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 95-209 6.16e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 6.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859   95 VVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIea 174
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462517859  175 kNKDDLTpLLLAVSGKKQQMVEFLIKKKANVNAVD 209
Cdd:PHA02876   238 -NKNDLS-LLKAIRNEDLETSLLLYDAGFSVNSID 270
Rabaptin pfam03528
Rabaptin;
1130-1350 6.82e-03

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 40.86  E-value: 6.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1130 ESVEERLSQLQSEN---MLLRQQLDDAHNKADNKektviniqdqFHAIVQKLQAESEKQSLLLEERNKELISECNHLKER 1206
Cdd:pfam03528    4 EDLQQRVAELEKENaefYRLKQQLEAEFNQKRAK----------FKELYLAKEEDLKRQNAVLQEAQVELDALQNQLALA 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1207 QYQYENEKAeREVVVRQLQQELADTLKKQ----------SMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDR 1276
Cdd:pfam03528   74 RAEMENIKA-VATVSENTKQEAIDEVKSQwqeevaslqaIMKETVREYEVQFHRRLEQERAQWNQYRESAEREIADLRRR 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1277 HTEAVRcAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNAnlsEDEKEQLK--KLMELKQSLE----CNLDQEM 1350
Cdd:pfam03528  153 LSEGQE-EENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTEA---EDKIKELEasKMKELNHYLEaeksCRTDLEM 228
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 989-1335 7.90e-03

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 40.90  E-value: 7.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  989 NSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMnfdVSNLKDNNEILSQQLFK 1068
Cdd:pfam09731  121 KSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKA---TDSALQKAEALAEKLKE 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1069 TESKLNSLEIEfhhtrdALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYigkQESVEERLSQLQSEnmlLRQ 1148
Cdd:pfam09731  198 VINLAKQSEEE------AAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQY---KELVASERIVFQQE---LVS 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1149 QLDD--AHNKADNKEKTviniqDQFHAIVQKLQAEsekqsllLEERNKELIsecnHLKERqyqyENEKAEREVVVRQLQQ 1226
Cdd:pfam09731  266 IFPDiiPVLKEDNLLSN-----DDLNSLIAHAHRE-------IDQLSKKLA----ELKKR----EEKHIERALEKQKEEL 325

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1227 ELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKL-GQIRNQLQEAQDRHTEAVRCAEK----------MQDHKQKLE 1295
Cdd:pfam09731  326 DKLAEELSARLEEVRAADEAQLRLEFEREREEIRESYeEKLRTELERQAEAHEEHLKDVLVeqeielqrefLQDIKEKVE 405

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 2462517859 1296 KDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKL 1335
Cdd:pfam09731  406 EERAGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQL 445
PRK09039 PRK09039
peptidoglycan -binding protein;
967-1077 8.44e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 40.33  E-value: 8.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  967 LTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELElafqRARDECSRLQD 1046
Cdd:PRK09039    44 LSREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELA----GAGAAAEGRAG 119

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462517859 1047 KMNFDVSNLKDNN-------EILSQQLFKTESKLNSLE 1077
Cdd:PRK09039   120 ELAQELDSEKQVSaralaqvELLNQQIAALRRQLAALE 157
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 840-1163 9.96e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 40.81  E-value: 9.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  840 LEMELRTVKSNLN----QVVQERNDAQRQLSR----EQNARMLQDGI-----LTNHLSKQKEIEMAQKKMNSENSHSHEE 906
Cdd:PRK10929    28 ITQELEQAKAAKTpaqaEIVEALQSALNWLEErkgsLERAKQYQQVIdnfpkLSAELRQQLNNERDEPRSVPPNMSTDAL 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  907 EKDLSHKNSMLQEEIAMLrleidtikNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLtQTISQYN-----GRLSVL 981
Cdd:PRK10929   108 EQEILQVSSQLLEKSRQA--------QQEQDRAREISDSLSQLPQQQTEARRQLNEIERRL-QTLGTPNtplaqAQLTAL 178

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859  982 TAENAMLNSKLE---------NEKQSKERLEAEV-ESYHSRLAAAIHD-RDQ-SETSKRELELAFQRARDECSRLQDKMN 1049
Cdd:PRK10929   179 QAESAALKALVDelelaqlsaNNRQELARLRSELaKKRSQQLDAYLQAlRNQlNSQRQREAERALESTELLAEQSGDLPK 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462517859 1050 FDVSNLKDNNEI---LSQQ------LFKTESKLNSLEIEFHHTRDALREKT--LGLERVQKDLSQTQ-CQMKEMEqKYQn 1117
Cdd:PRK10929   259 SIVAQFKINRELsqaLNQQaqrmdlIASQQRQAASQTLQVRQALNTLREQSqwLGVSNALGEALRAQvARLPEMP-KPQ- 336

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462517859 1118 eQVKvnkyigkQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKT 1163
Cdd:PRK10929   337 -QLD-------TEMAQLRVQRLRYEDLLNKQPQLRQIRQADGQPLT 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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