NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462520539|ref|XP_054222499|]
View 

ras suppressor protein 1 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-199 8.18e-39

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 8.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886   187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263


                  ....*.
gi 2462520539 194 VLPPEL 199
Cdd:COG4886   264 DLPPLA 269
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-199 8.18e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 8.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886   187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263


                  ....*.
gi 2462520539 194 VLPPEL 199
Cdd:COG4886   264 DLPPLA 269
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-211 8.43e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.27  E-value: 8.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  31 LDVNGLFTLSH-----ITQLVLSHNKLTMVPPNIAelKNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370  185 LKILGLTTIPAcipeqITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 106 GSlpALEVLDLTYNNLS--ENSLPGNFFYL-------TTLRA--------LYLSDNDFEILPPDIGklTKLQILSLRDND 168
Cdd:PRK15370  261 PS--ALQSLDLFHNKISclPENLPEELRYLsvydnsiRTLPAhlpsgithLNVQSNSLTALPETLP--PGLKTLEAGENA 336

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2462520539 169 LISLPKEIGelTQLKELHIQGNRLTVLPPELASTADTCRPTQN 211
Cdd:PRK15370  337 LTSLPASLP--PELQVLDVSKNQITVLPETLPPTITTLDVSRN 377
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-193 2.49e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  42 ITQLVLSHNKLTMVPpNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNL 121
Cdd:cd21340     4 ITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 122 S-----ENslpgnffyLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKEL 185
Cdd:cd21340    81 SvveglEN--------LTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQL 147


                  ....*...
gi 2462520539 186 HIQGNRLT 193
Cdd:cd21340   148 DASNNQIS 155
LRR_8 pfam13855
Leucine rich repeat;
64-121 1.63e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-199 8.18e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.45  E-value: 8.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  34 NGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Cdd:COG4886   107 EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 114 LDLTYNNLSEnsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPkEIGELTQLKELHIQGNRLT 193
Cdd:COG4886   187 LDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263


                  ....*.
gi 2462520539 194 VLPPEL 199
Cdd:COG4886   264 DLPPLA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-201 6.05e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 6.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  27 ISNMLDVNGLFTLSHITQLVLSHNKltmvppNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFG 106
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 107 SLPALEVLDLTYNNLSEnslpgnffylttlralylsdndfeiLPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELH 186
Cdd:COG4886   157 NLTNLKSLDLSNNQLTD-------------------------LPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELD 211

                         170
                  ....*....|....*
gi 2462520539 187 IQGNRLTVLPPELAS 201
Cdd:COG4886   212 LSGNQLTDLPEPLAN 226
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-201 1.01e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNl 121
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 122 senslpgNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELAS 201
Cdd:COG4886   108 -------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGN 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-211 8.43e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.27  E-value: 8.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  31 LDVNGLFTLSH-----ITQLVLSHNKLTMVPPNIAelKNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGF 105
Cdd:PRK15370  185 LKILGLTTIPAcipeqITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 106 GSlpALEVLDLTYNNLS--ENSLPGNFFYL-------TTLRA--------LYLSDNDFEILPPDIGklTKLQILSLRDND 168
Cdd:PRK15370  261 PS--ALQSLDLFHNKISclPENLPEELRYLsvydnsiRTLPAhlpsgithLNVQSNSLTALPETLP--PGLKTLEAGENA 336

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2462520539 169 LISLPKEIGelTQLKELHIQGNRLTVLPPELASTADTCRPTQN 211
Cdd:PRK15370  337 LTSLPASLP--PELQVLDVSKNQITVLPETLPPTITTLDVSRN 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-193 2.94e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 2.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113  182 NSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKN 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHI 187
Cdd:PLN00113  262 LQYLFLYQNKLS-GPIPPSIFSLQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQL 339


                  ....*.
gi 2462520539 188 QGNRLT 193
Cdd:PLN00113  340 WSNKFS 345
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-193 4.58e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 4.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  40 SHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEVLD 115
Cdd:PLN00113   69 SRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLETLD 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 116 LTyNNLSENSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT 193
Cdd:PLN00113  147 LS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLS 225
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-193 4.75e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 4.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  34 NGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPA 110
Cdd:PLN00113  278 PSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNN 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 111 LEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQ 188
Cdd:PLN00113  358 LTVLDLSTNNLT-GEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436


                  ....*
gi 2462520539 189 GNRLT 193
Cdd:PLN00113  437 NNNLQ 441
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-201 7.33e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 7.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  40 SHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDL 116
Cdd:PLN00113  356 NNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDI 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 117 TYNNLSENsLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-V 194
Cdd:PLN00113  436 SNNNLQGR-INSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgE 514


                  ....*..
gi 2462520539 195 LPPELAS 201
Cdd:PLN00113  515 IPDELSS 521
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 20-199 2.32e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.71  E-value: 2.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  20 VDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNiAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRL 98
Cdd:PLN00113   98 INLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  99 -NTLPRGFGSLPALEVLDLT------------------------YNNLSeNSLPGNFFYLTTLRALYLSDNDFE-ILPPD 152
Cdd:PLN00113  177 vGKIPNSLTNLTSLEFLTLAsnqlvgqiprelgqmkslkwiylgYNNLS-GEIPYEIGGLTSLNHLDLVYNNLTgPIPSS 255

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462520539 153 IGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLTVLPPEL 199
Cdd:PLN00113  256 LGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIPEL 303
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
34-196 2.60e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 63.64  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  34 NGLFTL-----SHITQLVLSHNKLTMVPPNIAELKNLEV-----------------LNFFNNQIEELPTQISSLQKLKHL 91
Cdd:PRK15387  211 SGLTTLpdclpAHITTLVIPDNNLTSLPALPPELRTLEVsgnqltslpvlppglleLSIFSNPLTHLPALPSGLCKLWIF 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  92 NLGMNRLNTLPRGF----------GSLPAL--EVLDLTYNNLSENSLPGnffYLTTLRALYLSDNDFEILPPDIGKLTKL 159
Cdd:PRK15387  291 GNQLTSLPVLPPGLqelsvsdnqlASLPALpsELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKL 367

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462520539 160 QILSLRDNDLISLPKEIGEL--------------TQLKELHIQGNRLTVLP 196
Cdd:PRK15387  368 WAYNNRLTSLPALPSGLKELivsgnrltslpvlpSELKELMVSGNRLTSLP 418
PLN03150 PLN03150
hypothetical protein; Provisional
 78-144 2.09e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.99  E-value: 2.09e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462520539  78 LPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDN 144
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN-GSIPESLGQLTSLRILNLNGN 500
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-193 2.49e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  42 ITQLVLSHNKLTMVPpNIAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTYNNL 121
Cdd:cd21340     4 ITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 122 S-----ENslpgnffyLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKEL 185
Cdd:cd21340    81 SvveglEN--------LTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQL 147


                  ....*...
gi 2462520539 186 HIQGNRLT 193
Cdd:cd21340   148 DASNNQIS 155
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 11-170 1.73e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  11 ESREKNQPEVDMSDRGISNML-DVNGLFTLSHITQLVLSHNKLT-MVPPNIAELKNLEVLNFFNNQIE-ELPTQISSLQK 87
Cdd:PLN00113  445 NSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKK 524

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  88 LKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLSeNSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRD 166
Cdd:PLN00113  525 LVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAG 603


                  ....
gi 2462520539 167 NDLI 170
Cdd:PLN00113  604 NIDL 607
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 35-174 1.83e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 1.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  35 GLFTLSHITQLVLSHNKLTMVpPNIAELKNLEVLNFFNNQIEELpTQISSLQKLKHLNLGMNRlntLPRG---------- 104
Cdd:cd21340    41 NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQR---LPPGekltfdprsl 115

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462520539 105 FGSLPALEVLDLTYNNLSEnslPGNFFYLTTLRALYLSDN---DFEILPPDIGKLTKLQILSLRDNDLISLPK 174
Cdd:cd21340   116 AALSNSLRVLNISGNNIDS---LEPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
PLN03150 PLN03150
hypothetical protein; Provisional
 51-193 1.55e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  51 KLTMVPP--NIAELKNLEVLNFFNNQIEELPTQISSLQKLKH-----LNLGMNRLNTLPR---------GFGSLPALEVL 114
Cdd:PLN03150  341 TIVLQPKkgTHAIINAIEVFEIITAESKTLLEEVSALQTLKSslglpLRFGWNGDPCVPQqhpwsgadcQFDSTKGKWFI 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 115 D-LTYNNLS-ENSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGN 190
Cdd:PLN03150  421 DgLGLDNQGlRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGN 500


                  ...
gi 2462520539 191 RLT 193
Cdd:PLN03150  501 SLS 503
LRR_8 pfam13855
Leucine rich repeat;
64-121 1.63e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  64 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 1.69e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462520539  86 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDF 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
40-193 4.11e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.77  E-value: 4.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  40 SHITQLVLSHNKLTMVPPNIAELKNLEVlnfFNNQIEELPTQISSLQKLKHLNlgmNRLNTLPrgfgSLPA-LEVLDLTY 118
Cdd:PRK15387  322 SELCKLWAYNNQLTSLPTLPSGLQELSV---SDNQLASLPTLPSELYKLWAYN---NRLTSLP----ALPSgLKELIVSG 391

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462520539 119 NNLSenSLPgnfFYLTTLRALYLSDNDFEILP--PdigklTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 193
Cdd:PRK15387  392 NRLT--SLP---VLPSELKELMVSGNRLTSLPmlP-----SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 52-182 4.40e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.87  E-value: 4.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539   52 LTMVPPNIAELknlevlnFFNN--QIEELPTQISSLQKLKHLNLgMN--RLNTLPRGFgSLPALEVLDL-------TYNN 120
Cdd:PLN03210   773 MTMLSPSLTRL-------FLSDipSLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsgcsrlrTFPD 843

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462520539  121 LSENslpgnffylttLRALYLSDNDFEILPPDIGKLTKLQILSLRD-NDLISLPKEIGELTQL 182
Cdd:PLN03210   844 ISTN-----------ISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHL 895
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-193 1.23e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  80 TQISSLQKLKHLN--LGMNRLNTLPRGFGSL-PALEVLDLTYNNLSENS---LPGNFFYLTTLRALYLSDND-----FEI 148
Cdd:cd00116   105 LRSSSLQELKLNNngLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASceaLAKALRANRDLKELNLANNGigdagIRA 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462520539 149 LPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRLT 193
Cdd:cd00116   185 LAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLT 234
LRR_8 pfam13855
Leucine rich repeat;
109-169 1.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462520539 109 PALEVLDLTYNNLSENSlPGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD-DGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 40-193 5.66e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  40 SHITQLVLSHNKLTMVP-PNIAEL----KNLEVLNFFNNQIEE-----LPTQISSLQKLKHLNLGMNRLN-----TLPRG 104
Cdd:cd00116   137 PALEKLVLGRNRLEGAScEALAKAlranRDLKELNLANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTdegasALAET 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 105 FGSLPALEVLDLTYNNLSENSL----PGNFFYLTTLRALYLSDNDfeilppdigkltklqilsLRDNDLISLPKEIGELT 180
Cdd:cd00116   217 LASLKSLEVLNLGDNNLTDAGAaalaSALLSPNISLLTLSLSCND------------------ITDDGAKDLAEVLAEKE 278

                         170
                  ....*....|...
gi 2462520539 181 QLKELHIQGNRLT 193
Cdd:cd00116   279 SLLELDLRGNKFG 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-204 1.93e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  32 DVNGLFTLSHITQLVLSHNKLTMVPPnIAELKNLEVLNFFNNQIEELptqisSLQKLKHLNLGMNRLNTLPRGFGSLPAL 111
Cdd:COG4886   242 DLPELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLELLI 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 112 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 191
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395

                         170
                  ....*....|...
gi 2462520539 192 LTVLPPELASTAD 204
Cdd:COG4886   396 TTAGVLLLTLALL 408
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 32-115 2.02e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  32 DVNGLFTLSH-ITQLVLSHNKLTMVPPnIAELKNLEVLNFFNNQI---EELPTQISSLQKLKHLNLGMNRLNTLPRGFGS 107
Cdd:cd21340   111 DPRSLAALSNsLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQIsdlEELLDLLSSWPSLRELDLTGNPVCKKPKYRDK 189

                          90
                  ....*....|..
gi 2462520539 108 L----PALEVLD 115
Cdd:cd21340   190 IilasKSLEVLD 201
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-195 3.49e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539  60 AELKNLEVLNFFNNQI-----EELPTQISSLQKLKHLNLGMNRLN-----TLPRGFGSLPALEVLDLTYNNLSE------ 123
Cdd:COG5238   233 KGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGDegaial 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520539 124 -NSLPGNffylTTLRALYLSDNDF-----EILPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRL 192
Cdd:COG5238   313 aEGLQGN----KTLHTLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNI 388


                  ...
gi 2462520539 193 TVL 195
Cdd:COG5238   389 GKQ 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH