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Conserved domains on  [gi|2462523617|ref|XP_054223978|]
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von Willebrand factor C and EGF domain-containing protein isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 675-893 1.04e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  675 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 746
Cdd:PHA03247  2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  747 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 816
Cdd:PHA03247  2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462523617  817 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 893
Cdd:PHA03247  2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 458-516 9.75e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.57  E-value: 9.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 458 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 516
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 343-397 2.22e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.72  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462523617 343 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 397
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
578-633 2.64e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.64e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617  578 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 633
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 7.84e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 7.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462523617  142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.62e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.62e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462523617 190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 636-691 1.56e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.40  E-value: 1.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 636 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 691
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 400-445 4.39e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 36.25  E-value: 4.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462523617 400 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 445
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 675-893 1.04e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  675 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 746
Cdd:PHA03247  2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  747 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 816
Cdd:PHA03247  2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462523617  817 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 893
Cdd:PHA03247  2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 458-516 9.75e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 9.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 458 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 516
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
458-516 1.68e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 1.68e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617  458 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 516
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 343-397 2.22e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462523617 343 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 397
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
578-633 2.64e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.64e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617  578 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 633
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 7.84e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 7.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462523617  142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
VWC smart00214
von Willebrand factor (vWF) type C domain;
343-397 8.11e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 8.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617  343 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 397
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.62e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.62e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462523617 190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 636-691 1.56e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 636 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 691
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 578-633 1.99e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 578 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 633
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 758-892 2.95e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 758 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 832
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462523617 833 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 892
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 3.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462523617  181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 4.00e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462523617 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054     1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 400-445 4.39e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462523617 400 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 445
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 9.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462523617 142 DIDECVTSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054     1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
VWC smart00214
von Willebrand factor (vWF) type C domain;
636-691 9.43e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 9.43e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617  636 CNYEGRKVANGQVFTldDEPCTRCTCQLGE-VSCEKVPCQRA--CADP--ALLPGDCCSSC 691
Cdd:smart00214   1 CVHNGRVYNDGETWK--PDPCQICTCLDGTtVLCDPVECPPPpdCPNPerVKPPGECCPRC 59
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 675-893 1.04e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  675 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 746
Cdd:PHA03247  2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  747 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 816
Cdd:PHA03247  2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462523617  817 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 893
Cdd:PHA03247  2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 458-516 9.75e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 9.75e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 458 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 516
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
458-516 1.68e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 1.68e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617  458 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 516
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 343-397 2.22e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462523617 343 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 397
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
578-633 2.64e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.81  E-value: 2.64e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617  578 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 633
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 723-893 2.86e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  723 TEAPVNCSSCPGPPTASPSR-PVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATfPGEPGASP----RLSPGP 797
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPtsaqPTAPPP 2841

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  798 STPPGAPTLPLA---SPGAP---QPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLS 871
Cdd:PHA03247  2842 PPGPPPPSLPLGgsvAPGGDvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921

                          170       180
                   ....*....|....*....|..
gi 2462523617  872 PTTSRLSTALAATTHPGPQQPP 893
Cdd:PHA03247  2922 QPPPPPQPQPPPPPPPRPQPPL 2943
motB PRK12799
flagellar motor protein MotB; Reviewed
 754-898 4.28e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.94  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 754 TNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGasprlSPGPSTPPGAPTLPLASPgapqpppvTPERSFSASGAQIV 833
Cdd:PRK12799  288 TGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAA-----IPSPAVIPSSVTTQSATT--------TQASAVALSSAGVL 354

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462523617 834 SRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPR-VLSPTTSRLSTALAATthPGPQQPPVGASR 898
Cdd:PRK12799  355 PSDVTLPGTVALPAAEPVNMQPQPMSTTETQQSSTgNITSTANGPTTSLPAA--PASNIPVSPTSR 418
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
711-893 4.49e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 711 AFSKAGRSlhGDTeAPVNCSSCP---GPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPG-- 785
Cdd:PRK12323  362 AFRPGQSG--GGA-GPATAAAAPvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAArq 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 786 ----------EPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLltEASALSMMDP 855
Cdd:PRK12323  439 asargpggapAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF--ASPAPAQPDA 516

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462523617 856 SPS---KTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 893
Cdd:PRK12323  517 APAgwvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAAT 557
PHA03247 PHA03247
large tegument protein UL36; Provisional
 733-893 5.80e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  733 PGPPTASPSRPVLHLLQLLLRTNlmktqtlPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPG 812
Cdd:PHA03247  2557 PAAPPAAPDRSVPPPRPAPRPSE-------PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP 2629

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  813 APQPPPVT-PERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLsTALAATTHPGPQQ 891
Cdd:PHA03247  2630 SPSPAANEpDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL-TSLADPPPPPPTP 2708


                   ..
gi 2462523617  892 PP 893
Cdd:PHA03247  2709 EP 2710
PHA03378 PHA03378
EBNA-3B; Provisional
 753-893 7.02e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 753 RTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQI 832
Cdd:PHA03378  663 KPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPG 742

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462523617 833 VSRWPP-LPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 893
Cdd:PHA03378  743 RARPPAaAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 7.84e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 7.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462523617  142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
VWC smart00214
von Willebrand factor (vWF) type C domain;
343-397 8.11e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.27  E-value: 8.11e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617  343 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 397
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.62e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.62e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462523617 190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 732-904 1.14e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  732 CPGPPTASPSRPVLHLLQLLLRTnlmktqTLPTSPAGAHGPHSlalGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASP 811
Cdd:PHA03307    72 PPGPGTEAPANESRSTPTWSLST------LAPASPAREGSPTP---PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  812 G---APQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMmdPSPSKTPITLLGPRVLSPTTSRL-STALAATTHP 887
Cdd:PHA03307   143 SpgpPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAP--SSPPAEPPPSTPPAAASPRPPRRsSPISASASSP 220

                          170
                   ....*....|....*..
gi 2462523617  888 GPQQPPVGASRGEESTM 904
Cdd:PHA03307   221 APAPGRSAADDAGASSS 237
PHA03378 PHA03378
EBNA-3B; Provisional
 735-898 1.52e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 735 PPTASPSRPVLHLLQLLLRTNLMktQTLPTSPAGAHGPH------SLALGLTATFPGEPGASPRlSPGPST------PPG 802
Cdd:PHA03378  616 PETSAPRQWPMPLRPIPMRPLRM--QPITFNVLVFPTPHqppqveITPYKPTWTQIGHIPYQPS-PTGANTmlpiqwAPG 692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 803 APTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPiTLLGPRVLSPTTSRLSTAL- 881
Cdd:PHA03378  693 TMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP-GRARPPAAAPGRARPPAAAp 771

                         170
                  ....*....|....*...
gi 2462523617 882 -AATTHPGPQQPPVGASR 898
Cdd:PHA03378  772 gAPTPQPPPQAPPAPQQR 789
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 636-691 1.56e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 636 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 691
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 578-633 1.99e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462523617 578 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 633
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
763-903 2.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 763 PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGT 842
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617 843 LLTEASAlsmmdPSPSKTPItllgPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEEST 903
Cdd:PRK12323  445 GGAPAPA-----PAPAAAPA----AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 758-892 2.95e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 758 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 832
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462523617 833 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 892
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 3.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462523617  181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 793-893 3.50e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 793 LSPGPSTPPGAPTLPLASPGAPQPPPVTPersFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTpitllgPRVLSP 872
Cdd:PRK14950  360 LVPVPAPQPAKPTAAAPSPVRPTPAPSTR---PKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHT------PESAPK 430

                          90       100
                  ....*....|....*....|.
gi 2462523617 873 TTSRLSTALAATTHPGPQQPP 893
Cdd:PRK14950  431 LTRAAIPVDEKPKYTPPAPPK 451
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 4.00e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462523617 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054     1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 400-445 4.39e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462523617 400 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 445
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
PHA03379 PHA03379
EBNA-3A; Provisional
 698-894 6.58e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 698 LEEKQGLSPHGNVAFSKAGRSLHGDteapvncsscPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGP----H 773
Cdd:PHA03379  391 LMRAGKLTERAREALEKASEPTYGT----------PRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPlhdqH 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617 774 SLALGLTATFPgePGASPRLSPGpSTPPGAPTLPLASPgAPQPPPVTP-ERSFSASGAQIVSRWP------PLPGTLLTE 846
Cdd:PHA03379  461 SMAPCPVAQLP--PGPLQDLEPG-DQLPGVVQDGRPAC-APVPAPAGPiVRPWEASLSQVPGVAFapvmpqPMPVEPVPV 536

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2462523617 847 ASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPV 894
Cdd:PHA03379  537 PTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAPWTPNPPRSPS 584
PHA03247 PHA03247
large tegument protein UL36; Provisional
 733-894 9.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  733 PGPPTASPSRPVLHLLQLLLRTNLMKTQTL--------PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAP 804
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAARQASPALPAAPappavpagPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462523617  805 TLPLASPGAPQPP-PVTPERSFSASGAQIVSRWPPLPG--TLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTAL 881
Cdd:PHA03247  2790 SLSESRESLPSPWdPADPPAAVLAPAAALPPAASPAGPlpPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                          170
                   ....*....|....
gi 2462523617  882 AATTHPG-PQQPPV 894
Cdd:PHA03247  2870 SPAAKPAaPARPPV 2883
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 9.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 9.33e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462523617 142 DIDECVTSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054     1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
VWC smart00214
von Willebrand factor (vWF) type C domain;
636-691 9.43e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 9.43e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462523617  636 CNYEGRKVANGQVFTldDEPCTRCTCQLGE-VSCEKVPCQRA--CADP--ALLPGDCCSSC 691
Cdd:smart00214   1 CVHNGRVYNDGETWK--PDPCQICTCLDGTtVLCDPVECPPPpdCPNPerVKPPGECCPRC 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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