ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  735 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 814
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  815 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 894
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  895 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 965
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 2462524930  966 WHYMK 970
Cdd:cd23427    142 WHWDP 146

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  608 VRLRVLQNGEKNKNRSVTILGpdispgrktqsvhtekkekicvtkysgiemdqvEFHQFLERCTEILNLPSAARRLYNEK 687
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG---------------------------------EFQLFLERCTTALNLPFAARRLFDEK 47

                           90       100
                   ....*....|....*....|....*....
gi 2462524930  688 GKEIFALKDLQRDELVYVSCGELWINPDL 716
Cdd:cd17156     48 GKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462524930    1 MNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGPLWVSKGEGFSP 52
Cdd:cd17157     35 LNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSKGEGFSP 86

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462524930  402 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 446
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  735 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 814
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  815 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 894
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  895 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 965
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 2462524930  966 WHYMK 970
Cdd:cd23427    142 WHWDP 146

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  608 VRLRVLQNGEKNKNRSVTILGpdispgrktqsvhtekkekicvtkysgiemdqvEFHQFLERCTEILNLPSAARRLYNEK 687
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG---------------------------------EFQLFLERCTTALNLPFAARRLFDEK 47

                           90       100
                   ....*....|....*....|....*....
gi 2462524930  688 GKEIFALKDLQRDELVYVSCGELWINPDL 716
Cdd:cd17156     48 GKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462524930    1 MNLNLPARYFYDLYGRKIEDISKVPLLEKCLQNSITPLRGPLWVSKGEGFSP 52
Cdd:cd17157     35 LNLGSPARVLYDWEGKEIKDLSEAPKLDKCLQNSSTPVLGPLWVSKGEGFSP 86

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  1110 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 1172
Cdd:smart00537    1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930   604 PYAPVRLRVLQNGEKNKNRSVTILGPDISPgrktqsvhtekkekicvtkysgiemdqvEFHQFLERCTEI--LNLPSAAR 681
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGVRLVVNRKRFK----------------------------SFEALLQDLTEVvkLDLPHGVR 53

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 2462524930   682 RLYNEKGKEIFALKDLQRDELVYVSCGELWINPDLS 717
Cdd:smart00537   54 KLYTLDGKKVTSLDELEDGGSYVASGTEAFKKVDYG 89

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462524930  219 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 252
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

ricin B-type lectin domain, beta-trefoil fold, found in doublecortin domain-containing protein 1 (DCDC1) and similar proteins; DCDC1, also called doublecortin domain-containing 5 protein (DCDC5), is a microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis. In addition to doublecortin-like domains, DCDC1 may also contain a ricin B-type lectin domain in the middle region. The ricin B-type lectin domain shows a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain may harbor a putative sugar-binding pocket.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  735 AKIQIFCSTHKIEALVLEVQSDIVSGSKLAVHKPVAifgeekqvtepeekqmqedplttenasseildshvrahlrmkac 814
Cdd:cd23427      1 DQIRQYCALRNPEDLVLEVSGPLVAGSKLIVNKCVL-------------------------------------------- 36

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  815 htlpryawqetshdfdeddslpkktekglfenvepqkkhscspkhsklhkhcHQQFEYRDGQIISHAAPQLVLGVQGPNL 894
Cdd:cd23427     37 ----------------------------------------------------LQQFVFEDGFISCCSNPNLVLGVQGSEL 64

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  895 RSGMEVVLVEKKSDGSHQRWIHQEDsrtFHLVSNP--DLVLAVSMTKTRNE-------VCGYPVIVQKYKPYNNGAANQK 965
Cdd:cd23427     65 GRGAEVVLVKKKPDDINQRWILRED---GHIMSKPnyDLVLTVSMPSTTPGdsssplsYIGCAVILQKYKGYSYGRANQK 141

                   ....*
gi 2462524930  966 WHYMK 970
Cdd:cd23427    142 WHWDP 146

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  608 VRLRVLQNGEKNKNRSVTILGpdispgrktqsvhtekkekicvtkysgiemdqvEFHQFLERCTEILNLPSAARRLYNEK 687
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVG---------------------------------EFQLFLERCTTALNLPFAARRLFDEK 47

                           90       100
                   ....*....|....*....|....*....
gi 2462524930  688 GKEIFALKDLQRDELVYVSCGELWINPDL 716
Cdd:cd17156     48 GKEHFTLKDLKRDQLVYVSCGEAWIDPKL 76

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930 1115 VKIIAYKNGDGY-RNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIftlrdlvlwaldesflqrdsekqkqdaa 1193
Cdd:cd17158      1 VKILAYKNGEGRlRDGVLIIGSTFPGLLDQCTHRLGLARAARRLYTADGTLI---------------------------- 52

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462524930 1194 pvgkeqiivesmeenprmkvknrlfaksvtsdsldgidkslLTLILRNPIAIWVSCGEPFLP 1255
Cdd:cd17158     53 -----------------------------------------LTLILRYPIEVWVSCGEPFIP 73

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462524930 1373 KRVWIYLNGGR-PEDGTYAWGK--TISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMG 1440
Cdd:cd17072      1 VRLRVLKNGERdLERAVYVVGPdlELQLFLDRCTERLNLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462524930 1373 KRVWIYLNGGRPEDGTYAWGK-----TISELLQDCSSRLKM-THPARALYTPSGEPIQSWDDIERDMVICVSM 1439
Cdd:cd01617      1 KRITVFRNGDKNFKGVKVLVKprrfrTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  867 HQQFEYRDGQIIsHAAPQLVLGVQGPNLRSGMEVVLVEKKS--DGSHQRWIHQEDSrTFHLVSNPDLVLAVSMTKTRNev 944
Cdd:cd23454     39 SQLWRYDDGYLV-NKASGLVLDIQGGVVKSGTRLVQSPKKPskDANNQRWGLTADG-YIYLLSNPSLVLGIKGNETRE-- 114

                           90       100
                   ....*....|....*....|..
gi 2462524930  945 cGYPVIVQKYKPYNNgAANQKW 966
Cdd:cd23454    115 -GARVILQERKLQKD-ALNQRW 134

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462524930 1115 VKIIAYKNGDGYRNGKLIVAGTFPMLLTECTEQLGLARAASKVYTKDGTPIFTLRDL 1171
Cdd:cd17156      1 LRLRVLRNGEKDKNKAVTVVGEFQLFLERCTTALNLPFAARRLFDEKGKEHFTLKDL 57

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  608 VRLRVLQNGEKNkNRSVTILGpdispgrKTQSVHTekkekicvtkysgiemdqveFHQFLERCTEILNL-PSAARRLYNE 686
Cdd:cd01617      1 KRITVFRNGDKN-FKGVKVLV-------KPRRFRT--------------------FDQLLDELTEKLGLpTGGVRKLYTP 52

                           90       100
                   ....*....|....*....|..
gi 2462524930  687 KGKEIFALKDLQRDElVYVSCG 708
Cdd:cd01617     53 SGKLVKSLSDLEDGE-SYVVCG 73

Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462524930  665 QFLERCTEILNLPSAARRLYNEKGKEIFALKDLQRDELVYVSCGE 709
Cdd:cd17159     25 ELLDSCTERLGLRKPAKYLYTPDGEQIQSWDDIERDMLLCVSTGE 69

Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462524930 1374 RVWIYLNGGRPedgTYA--WGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDIERDMVICVSMGHGFK 1444
Cdd:cd17155      2 KVTAFKNGTRD---VFAkvTAPNIKILLEECTEKLGLNSAARRVFLADGTEVFEPKDIPRDADVYISTGEPFK 71

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462524930 1115 VKIIAYKNGDGYRNGKLIV-----AGTFPMLLTECTEQLGL-ARAASKVYTKDGTPIFTLRDLV 1172
Cdd:cd01617      1 KRITVFRNGDKNFKGVKVLvkprrFRTFDQLLDELTEKLGLpTGGVRKLYTPSGKLVKSLSDLE 64

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  878 ISHAAPQLVLGVQGPNLRSGMEVVLVEKkSDGSHQRW-IHQEDSRTFHLVS-NPDLVLAVSMTKTRNevcGYPVIVQKYk 955
Cdd:cd00161      5 IVNAASGKCLDVAGGSTANGAPVQQWTC-NGGANQQWtLTPVGDGYYTIRNvASGKCLDVAGGSTAN---GANVQQWTC- 79

                           90
                   ....*....|...
gi 2462524930  956 pynNGAANQKWHY 968
Cdd:cd00161     80 ---NGGDNQQWRL 89

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930  1110 THQKAVKIIAYKNGDGYRNG-KLIV----AGTFPMLLTECTEQLGL--ARAASKVYTKDGTPIFTLRDLV 1172
Cdd:smart00537    1 SLVKPKRIRFYRNGDRFFKGvRLVVnrkrFKSFEALLQDLTEVVKLdlPHGVRKLYTLDGKKVTSLDELE 70

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524930   604 PYAPVRLRVLQNGEKNKNRSVTILGPDISPgrktqsvhtekkekicvtkysgiemdqvEFHQFLERCTEI--LNLPSAAR 681
Cdd:smart00537    2 LVKPKRIRFYRNGDRFFKGVRLVVNRKRFK----------------------------SFEALLQDLTEVvkLDLPHGVR 53

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 2462524930   682 RLYNEKGKEIFALKDLQRDELVYVSCGELWINPDLS 717
Cdd:smart00537   54 KLYTLDGKKVTSLDELEDGGSYVASGTEAFKKVDYG 89

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462524930  219 GLNYSSMRLFDENGQEIKNPLSLKNEQKIWVSYG 252
Cdd:cd17072     38 NLPFAARRLFDENGKEIFTLRDLERDQLVYVSCG 71

Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462524930 1374 RVWIYLNG-GRPEDGTYAWGKTISELLQDCSSRLKMTHPARALYTPSGEPIQSWDDI 1429
Cdd:cd17157      2 RILVFKNGdGSEGYEIVADLDEFEQFLDACTSKLNLGSPARVLYDWEGKEIKDLSEA 58

GllA-1 domain, beta-trefoil fold, found in Mucor circinelloides Gellins and similar proteins; Gellin proteins act as central effectors of wound-induced protoplasmic gelation. They possess ten related N-terminal beta-trefoil domains (Gll-1 to Gll-10) that contribute to distinct gelation-related activities. The beta-trefoil domains show low sequence similarity to members of the functionally diverse ricin B lectin domain family. They are characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Each subdomain bears a potential sugar binding site. Gellin from M. circinelloides has been called GellinA (also known as GllA). The model corresponds to GllA-1 domain, which is a remote family member of the ricin B-type lectin domain.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462524930  402 AAEGTSLEGYKLILQKRHSGDDS--QKWVFGTDGCIYSKAYPQFVLT 446
Cdd:cd23454     60 IQGGVVKSGTRLVQSPKKPSKDAnnQRWGLTADGYIYLLSNPSLVLG 106

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462524930    1 MNLNLPARYFYDLYGRKIEDIskvpllekclqnSITPLRGPLWVSKG 47
Cdd:cd17072     37 LNLPFAARRLFDENGKEIFTL------------RDLERDQLVYVSCG 71