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Conserved domains on  [gi|2462525260|ref|XP_054224782|]
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caprin-1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Caprin-1_C super family cl25901
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
 359-518 2.00e-69

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


The actual alignment was detected with superfamily member pfam12287:

Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 225.44  E-value: 2.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 359 VQDLMAQMQGPYNFIQDSMLDFENQTlDPAIVSAQPmnPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSST 438
Cdd:pfam12287   1 LQDLMAQIQGTYNFMQDSMLDFDKPS-DSAIVSAQP--PSQSPDLSQMVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 439 SEGYTASQPLYQPShaTEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQagtSKPLHSSGINVNAAPFQSMQT 518
Cdd:pfam12287  78 SNACASSGSEYQFH--TSEPPQPEAIDPIQSSMSLPSELAPPSPPLSPASQPQVFQ---SKPASSSGINVNAAPFQSMQT 152
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
 132-247 4.11e-51

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


:

Pssm-ID: 436391  Cd Length: 116  Bit Score: 170.47  E-value: 4.11e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 132 RREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHAS 211
Cdd:pfam18293   1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462525260 212 IHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFD 247
Cdd:pfam18293  81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
 
Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
 359-518 2.00e-69

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 225.44  E-value: 2.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 359 VQDLMAQMQGPYNFIQDSMLDFENQTlDPAIVSAQPmnPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSST 438
Cdd:pfam12287   1 LQDLMAQIQGTYNFMQDSMLDFDKPS-DSAIVSAQP--PSQSPDLSQMVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 439 SEGYTASQPLYQPShaTEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQagtSKPLHSSGINVNAAPFQSMQT 518
Cdd:pfam12287  78 SNACASSGSEYQFH--TSEPPQPEAIDPIQSSMSLPSELAPPSPPLSPASQPQVFQ---SKPASSSGINVNAAPFQSMQT 152
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
 132-247 4.11e-51

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


Pssm-ID: 436391  Cd Length: 116  Bit Score: 170.47  E-value: 4.11e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 132 RREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHAS 211
Cdd:pfam18293   1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462525260 212 IHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFD 247
Cdd:pfam18293  81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 321-470 1.04e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.54  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260  321 VEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQM------QGPYNFIQDSMLDFENQTLDPAIVSAQP 394
Cdd:PRK10263   346 VASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVqyneplQQPVQPQQPYYAPAAEQPAQQPYYAPAP 425

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462525260  395 MNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPlvSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQAT 470
Cdd:PRK10263   426 EQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQT--EQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEET 499
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 327-492 3.92e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 46.34  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 327 LQQQPQAASPSVPEPHSLTPV--AQADPLVRRQRVQdlmAQMQG-PYNFIQDSMLDFENQTLDPAivsaQPMNPTQnmdM 403
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMggAMGQPPYYGQGPQ---QQFNGqPLGWPRMSMMPTPMGPGGPL----RPNGLAP---M 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 404 PQLVCPPVHSESRLAQPNQVPVQpeatqvplvsstsegytasqplYQPSHATEQRPQKEPIDQIQATISLNTDQTTAS-S 482
Cdd:TIGR01628 441 NAVRAPSRNAQNAAQKPPMQPVM----------------------YPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVlA 498

                         170
                  ....*....|
gi 2462525260 483 SLPAASQPQV 492
Cdd:TIGR01628 499 SATPQMQKQV 508
 
Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
 359-518 2.00e-69

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 225.44  E-value: 2.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 359 VQDLMAQMQGPYNFIQDSMLDFENQTlDPAIVSAQPmnPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSST 438
Cdd:pfam12287   1 LQDLMAQIQGTYNFMQDSMLDFDKPS-DSAIVSAQP--PSQSPDLSQMVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 439 SEGYTASQPLYQPShaTEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQagtSKPLHSSGINVNAAPFQSMQT 518
Cdd:pfam12287  78 SNACASSGSEYQFH--TSEPPQPEAIDPIQSSMSLPSELAPPSPPLSPASQPQVFQ---SKPASSSGINVNAAPFQSMQT 152
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
 132-247 4.11e-51

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


Pssm-ID: 436391  Cd Length: 116  Bit Score: 170.47  E-value: 4.11e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 132 RREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHAS 211
Cdd:pfam18293   1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2462525260 212 IHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFD 247
Cdd:pfam18293  81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 321-470 1.04e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.54  E-value: 1.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260  321 VEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQM------QGPYNFIQDSMLDFENQTLDPAIVSAQP 394
Cdd:PRK10263   346 VASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVqyneplQQPVQPQQPYYAPAAEQPAQQPYYAPAP 425

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462525260  395 MNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPlvSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQAT 470
Cdd:PRK10263   426 EQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQT--EQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEET 499
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 327-492 3.92e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 46.34  E-value: 3.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 327 LQQQPQAASPSVPEPHSLTPV--AQADPLVRRQRVQdlmAQMQG-PYNFIQDSMLDFENQTLDPAivsaQPMNPTQnmdM 403
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMggAMGQPPYYGQGPQ---QQFNGqPLGWPRMSMMPTPMGPGGPL----RPNGLAP---M 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462525260 404 PQLVCPPVHSESRLAQPNQVPVQpeatqvplvsstsegytasqplYQPSHATEQRPQKEPIDQIQATISLNTDQTTAS-S 482
Cdd:TIGR01628 441 NAVRAPSRNAQNAAQKPPMQPVM----------------------YPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVlA 498

                         170
                  ....*....|
gi 2462525260 483 SLPAASQPQV 492
Cdd:TIGR01628 499 SATPQMQKQV 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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