PR domain zinc finger protein 4 isoform X1 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
PR-SET_PRDM4 | cd19189 | PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ... |
405-544 | 3.38e-92 | |||
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation. : Pssm-ID: 380966 Cd Length: 133 Bit Score: 285.13 E-value: 3.38e-92
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zf_PR_Knuckle | pfam18445 | PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ... |
365-402 | 1.32e-23 | |||
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands). : Pssm-ID: 375871 Cd Length: 38 Bit Score: 93.89 E-value: 1.32e-23
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
639-664 | 8.65e-06 | |||
Zinc-finger double domain; : Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 42.74 E-value: 8.65e-06
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
667-690 | 3.29e-04 | |||
Zinc-finger double domain; : Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 38.51 E-value: 3.29e-04
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
695-720 | 3.14e-03 | |||
Zinc-finger double domain; : Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 3.14e-03
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Name | Accession | Description | Interval | E-value | |||
PR-SET_PRDM4 | cd19189 | PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ... |
405-544 | 3.38e-92 | |||
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation. Pssm-ID: 380966 Cd Length: 133 Bit Score: 285.13 E-value: 3.38e-92
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zf_PR_Knuckle | pfam18445 | PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ... |
365-402 | 1.32e-23 | |||
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands). Pssm-ID: 375871 Cd Length: 38 Bit Score: 93.89 E-value: 1.32e-23
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
639-664 | 8.65e-06 | |||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 42.74 E-value: 8.65e-06
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
667-690 | 3.29e-04 | |||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 38.51 E-value: 3.29e-04
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
433-540 | 9.15e-04 | |||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 40.01 E-value: 9.15e-04
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
695-720 | 3.14e-03 | |||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 3.14e-03
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Name | Accession | Description | Interval | E-value | ||||
PR-SET_PRDM4 | cd19189 | PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ... |
405-544 | 3.38e-92 | ||||
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation. Pssm-ID: 380966 Cd Length: 133 Bit Score: 285.13 E-value: 3.38e-92
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PR-SET_PRDM1 | cd19187 | PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ... |
409-541 | 4.39e-33 | ||||
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Pssm-ID: 380964 [Multi-domain] Cd Length: 128 Bit Score: 123.98 E-value: 4.39e-33
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PR-SET_PRDM10 | cd19194 | PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ... |
405-544 | 4.02e-32 | ||||
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation. Pssm-ID: 380971 Cd Length: 128 Bit Score: 121.30 E-value: 4.02e-32
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PR-SET_PRDM15 | cd19199 | PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ... |
404-543 | 9.47e-32 | ||||
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency. Pssm-ID: 380976 Cd Length: 126 Bit Score: 119.83 E-value: 9.47e-32
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PR-SET_PRDM-like | cd10534 | PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ... |
410-536 | 1.53e-28 | ||||
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Pssm-ID: 380932 Cd Length: 83 Bit Score: 109.21 E-value: 1.53e-28
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PR-SET_PRDM7_9 | cd19193 | PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ... |
407-544 | 1.57e-28 | ||||
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer. Pssm-ID: 380970 [Multi-domain] Cd Length: 129 Bit Score: 110.79 E-value: 1.57e-28
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zf_PR_Knuckle | pfam18445 | PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ... |
365-402 | 1.32e-23 | ||||
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands). Pssm-ID: 375871 Cd Length: 38 Bit Score: 93.89 E-value: 1.32e-23
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PR-SET_PRDM14 | cd19198 | PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ... |
408-546 | 6.73e-23 | ||||
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance. Pssm-ID: 380975 Cd Length: 133 Bit Score: 95.16 E-value: 6.73e-23
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PR-SET_PRDM12 | cd19196 | PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ... |
410-546 | 6.36e-21 | ||||
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation. Pssm-ID: 380973 [Multi-domain] Cd Length: 130 Bit Score: 89.34 E-value: 6.36e-21
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PR-SET_PRDM2 | cd19188 | PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ... |
410-535 | 1.15e-18 | ||||
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor. Pssm-ID: 380965 Cd Length: 123 Bit Score: 82.49 E-value: 1.15e-18
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PR-SET_PRDM6 | cd19191 | PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ... |
410-543 | 1.35e-17 | ||||
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro. Pssm-ID: 380968 Cd Length: 128 Bit Score: 79.83 E-value: 1.35e-17
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PR-SET_PRDM16_PRDM3 | cd19200 | PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ... |
408-534 | 4.72e-16 | ||||
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation. Pssm-ID: 380977 Cd Length: 135 Bit Score: 75.48 E-value: 4.72e-16
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PR-SET_PRDM8 | cd19192 | PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ... |
422-540 | 1.76e-14 | ||||
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3. Pssm-ID: 380969 Cd Length: 131 Bit Score: 70.92 E-value: 1.76e-14
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PR-SET_PRDM3 | cd19214 | PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ... |
389-547 | 3.71e-14 | ||||
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation. Pssm-ID: 380991 Cd Length: 158 Bit Score: 70.74 E-value: 3.71e-14
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PR-SET_ZFPM | cd19201 | PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ... |
408-532 | 3.86e-14 | ||||
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Pssm-ID: 380978 Cd Length: 122 Bit Score: 69.68 E-value: 3.86e-14
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PR-SET_PRDM11 | cd19195 | PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ... |
438-543 | 1.62e-11 | ||||
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation. Pssm-ID: 380972 Cd Length: 127 Bit Score: 62.18 E-value: 1.62e-11
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PR-SET_PRDM13 | cd19197 | PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ... |
475-543 | 1.04e-09 | ||||
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits. Pssm-ID: 380974 Cd Length: 103 Bit Score: 56.37 E-value: 1.04e-09
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PR-SET_PRDM16 | cd19213 | PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ... |
389-534 | 1.24e-09 | ||||
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation. Pssm-ID: 380990 Cd Length: 162 Bit Score: 57.96 E-value: 1.24e-09
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PR-SET_PRDM5 | cd19190 | PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ... |
433-535 | 1.44e-08 | ||||
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Pssm-ID: 380967 Cd Length: 127 Bit Score: 53.84 E-value: 1.44e-08
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
639-664 | 8.65e-06 | ||||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 42.74 E-value: 8.65e-06
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PR-SET_PRDM17 | cd10520 | PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ... |
433-532 | 2.52e-05 | ||||
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation. Pssm-ID: 380918 Cd Length: 121 Bit Score: 44.33 E-value: 2.52e-05
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
667-690 | 3.29e-04 | ||||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 38.51 E-value: 3.29e-04
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zf-C2H2 | pfam00096 | Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ... |
653-675 | 5.96e-04 | ||||
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter. Pssm-ID: 395048 [Multi-domain] Cd Length: 23 Bit Score: 37.66 E-value: 5.96e-04
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SET | smart00317 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ... |
433-540 | 9.15e-04 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 40.01 E-value: 9.15e-04
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
695-720 | 3.14e-03 | ||||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 3.14e-03
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Blast search parameters | ||||
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