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Conserved domains on  [gi|2462538700|ref|XP_054231288|]
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trans-3-hydroxy-L-proline dehydratase isoform X3 [Homo sapiens]

Protein Classification

4-hydroxyproline epimerase; proline racemase family protein( domain architecture ID 1905033)

4-hydroxyproline epimerase catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp)| proline racemase family protein similar to trans-3-hydroxy-L-proline (t3LHyp) dehydratase (aka 4-hydroxyproline 2-epimerase) that catalyzes the dehydration of t3LHyp to delta(1)-pyrroline-2-carboxylate (Pyr2C), and the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_racemase super family cl42407
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 22-314 1.88e-140

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


The actual alignment was detected with superfamily member pfam05544:

Pssm-ID: 478179  Cd Length: 325  Bit Score: 399.75  E-value: 1.88e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  22 VVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYS 101
Cdd:pfam05544   1 VVDSHTEGEPGRVVVGGVPPLPGATMAEKRRYFARDHDHLRRFLMFEPRGHDMMSGALLVPPKRPDADAGVIFMEPSGYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 102 SMCGHAVLALGRFALDFGLVPAPpagTREARVNIHCPCGLVTAFVACEDGRsHGPVRFHSVPAFVLATDLMVDVPGHGKV 181
Cdd:pfam05544  81 PMCGHNTIGVVTVLLETGIVPPQ---EPETRLNLETPAGLVEARAECRDGK-VERVSLRNVPSFVYALDVEVEVPGLGRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 182 MVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKePTTNIC 261
Cdd:pfam05544 157 RVDIAYGGNFYAIVDAEQLGFDIEPAEARELVAAGEKIRDALNEQLKVVHPENPDIRGVSHVQLTGPPTRAEA-HARNAV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462538700 262 VFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKsSATGSVFTGKAVRE 314
Cdd:pfam05544 236 IIGPGAIDRSPCGTGTSARMAQLHAKGKLKVGETFVHE-SIIGSEFEGRVEGE 287
 
Name Accession Description Interval E-value
Pro_racemase pfam05544
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 22-314 1.88e-140

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


Pssm-ID: 398923  Cd Length: 325  Bit Score: 399.75  E-value: 1.88e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  22 VVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYS 101
Cdd:pfam05544   1 VVDSHTEGEPGRVVVGGVPPLPGATMAEKRRYFARDHDHLRRFLMFEPRGHDMMSGALLVPPKRPDADAGVIFMEPSGYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 102 SMCGHAVLALGRFALDFGLVPAPpagTREARVNIHCPCGLVTAFVACEDGRsHGPVRFHSVPAFVLATDLMVDVPGHGKV 181
Cdd:pfam05544  81 PMCGHNTIGVVTVLLETGIVPPQ---EPETRLNLETPAGLVEARAECRDGK-VERVSLRNVPSFVYALDVEVEVPGLGRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 182 MVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKePTTNIC 261
Cdd:pfam05544 157 RVDIAYGGNFYAIVDAEQLGFDIEPAEARELVAAGEKIRDALNEQLKVVHPENPDIRGVSHVQLTGPPTRAEA-HARNAV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462538700 262 VFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKsSATGSVFTGKAVRE 314
Cdd:pfam05544 236 IIGPGAIDRSPCGTGTSARMAQLHAKGKLKVGETFVHE-SIIGSEFEGRVEGE 287
PrdF COG3938
Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];
19-314 4.06e-117

Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];


Pssm-ID: 443139  Cd Length: 335  Bit Score: 340.92  E-value: 4.06e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  19 VLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNE 98
Cdd:COG3938     6 TITTIDAHTEGEPTRVVTGGVPPLPGNTMLEKRRYFAENYDWLRRLLMFEPRGHADMSGALLVPPTRPDADFGVIFMETS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  99 GYSSMCGHAVLALGRFALDFGLVPAPPAGTreaRVNIHCPCGLVTAFVACEDGRSHGpVRFHSVPAFVLATDLMVDVPGH 178
Cdd:COG3938    86 GYLPMCGHGTIGVATVLLETGLVPMTEPVT---EVVLDTPAGLVRARAEVEDGKVES-VTFENVPSFVYALDVEVEVPGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 179 GKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTdGKDAYTKEPTT 258
Cdd:COG3938   162 GTVTVDIAYGGNFYAIVDAQQLGLDLEPENARELIRLGLEIRDAANEQLEVVHPENPDINGVSHVEFT-GPPTDPDADAR 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462538700 259 NICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQmrAFKS-SATGSVFTGKAVRE 314
Cdd:COG3938   241 NAVVFGPGAIDRSPCGTGTSARMALLHARGELKVGE--TFVHeSIIGSRFTGRILEE 295
PRK13969 PRK13969
proline racemase; Provisional
 23-314 2.34e-77

proline racemase; Provisional


Pssm-ID: 184427 [Multi-domain]  Cd Length: 334  Bit Score: 239.37  E-value: 2.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  23 VDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSS 102
Cdd:PRK13969   10 IDSHTMGEPTRIVVGGLPKIPGKTMAEKKEYLEENNDSLRTALMSEPRGHNDMFGSIYTEPADETADFGIIFMDGGGYLN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 103 MCGHAVLALGRFALDFGLVPAPPAGTreaRVNIHCPCGLVTAFVACEDGRSHgPVRFHSVPAFVLATDLMVDVPGHGKVM 182
Cdd:PRK13969   90 MCGHGSIGAATCAVETGIVKVEEPYT---HIKLEAPAGMINARVKVEDGKAK-EVSIVNVPAFLYKKDVEIDVPDYGKVT 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 183 VDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSE-----DLAFLYGTilTDGKDAYTKept 257
Cdd:PRK13969  166 LDISFGGSFFAIVDAEQLGIKISPANSQKLNDLGMKIRHAVNEQIEIKHPVLEhiktvDLVEIYDE--AKHPDADYK--- 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462538700 258 tNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQmRAFKSSATGSVFTGKAVRE 314
Cdd:PRK13969  241 -NVVIFGQGQVDRSPCGTGTSAKMATLYAKGKLKVGE-EFVYESIIGTKFKGKILEE 295
 
Name Accession Description Interval E-value
Pro_racemase pfam05544
Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which ...
 22-314 1.88e-140

Proline racemase; This family consists of proline racemase (EC 5.1.1.4) proteins which catalyze the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterized as a co-factor-independent proline racemase.


Pssm-ID: 398923  Cd Length: 325  Bit Score: 399.75  E-value: 1.88e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  22 VVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYS 101
Cdd:pfam05544   1 VVDSHTEGEPGRVVVGGVPPLPGATMAEKRRYFARDHDHLRRFLMFEPRGHDMMSGALLVPPKRPDADAGVIFMEPSGYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 102 SMCGHAVLALGRFALDFGLVPAPpagTREARVNIHCPCGLVTAFVACEDGRsHGPVRFHSVPAFVLATDLMVDVPGHGKV 181
Cdd:pfam05544  81 PMCGHNTIGVVTVLLETGIVPPQ---EPETRLNLETPAGLVEARAECRDGK-VERVSLRNVPSFVYALDVEVEVPGLGRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 182 MVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDGKDAYTKePTTNIC 261
Cdd:pfam05544 157 RVDIAYGGNFYAIVDAEQLGFDIEPAEARELVAAGEKIRDALNEQLKVVHPENPDIRGVSHVQLTGPPTRAEA-HARNAV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462538700 262 VFADEQVDRSPTGSGVTARIALQYHKGLLELNQMRAFKsSATGSVFTGKAVRE 314
Cdd:pfam05544 236 IIGPGAIDRSPCGTGTSARMAQLHAKGKLKVGETFVHE-SIIGSEFEGRVEGE 287
PrdF COG3938
Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];
19-314 4.06e-117

Proline racemase/hydroxyproline epimerase [Amino acid transport and metabolism];


Pssm-ID: 443139  Cd Length: 335  Bit Score: 340.92  E-value: 4.06e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  19 VLSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNE 98
Cdd:COG3938     6 TITTIDAHTEGEPTRVVTGGVPPLPGNTMLEKRRYFAENYDWLRRLLMFEPRGHADMSGALLVPPTRPDADFGVIFMETS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  99 GYSSMCGHAVLALGRFALDFGLVPAPPAGTreaRVNIHCPCGLVTAFVACEDGRSHGpVRFHSVPAFVLATDLMVDVPGH 178
Cdd:COG3938    86 GYLPMCGHGTIGVATVLLETGLVPMTEPVT---EVVLDTPAGLVRARAEVEDGKVES-VTFENVPSFVYALDVEVEVPGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 179 GKVMVDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTdGKDAYTKEPTT 258
Cdd:COG3938   162 GTVTVDIAYGGNFYAIVDAQQLGLDLEPENARELIRLGLEIRDAANEQLEVVHPENPDINGVSHVEFT-GPPTDPDADAR 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462538700 259 NICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQmrAFKS-SATGSVFTGKAVRE 314
Cdd:COG3938   241 NAVVFGPGAIDRSPCGTGTSARMALLHARGELKVGE--TFVHeSIIGSRFTGRILEE 295
PRK13969 PRK13969
proline racemase; Provisional
 23-314 2.34e-77

proline racemase; Provisional


Pssm-ID: 184427 [Multi-domain]  Cd Length: 334  Bit Score: 239.37  E-value: 2.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  23 VDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSS 102
Cdd:PRK13969   10 IDSHTMGEPTRIVVGGLPKIPGKTMAEKKEYLEENNDSLRTALMSEPRGHNDMFGSIYTEPADETADFGIIFMDGGGYLN 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 103 MCGHAVLALGRFALDFGLVPAPPAGTreaRVNIHCPCGLVTAFVACEDGRSHgPVRFHSVPAFVLATDLMVDVPGHGKVM 182
Cdd:PRK13969   90 MCGHGSIGAATCAVETGIVKVEEPYT---HIKLEAPAGMINARVKVEDGKAK-EVSIVNVPAFLYKKDVEIDVPDYGKVT 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 183 VDIAYGGAFYAFVTAEKLGLDICSAKTRDLVDAASAVTEAVKAQFKINHPDSE-----DLAFLYGTilTDGKDAYTKept 257
Cdd:PRK13969  166 LDISFGGSFFAIVDAEQLGIKISPANSQKLNDLGMKIRHAVNEQIEIKHPVLEhiktvDLVEIYDE--AKHPDADYK--- 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462538700 258 tNICVFADEQVDRSPTGSGVTARIALQYHKGLLELNQmRAFKSSATGSVFTGKAVRE 314
Cdd:PRK13969  241 -NVVIFGQGQVDRSPCGTGTSAKMATLYAKGKLKVGE-EFVYESIIGTKFKGKILEE 295
PRK13971 PRK13971
4-hydroxyproline epimerase;
23-310 4.82e-55

4-hydroxyproline epimerase;


Pssm-ID: 184428  Cd Length: 333  Bit Score: 182.07  E-value: 4.82e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  23 VDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEGYSS 102
Cdd:PRK13971    9 IDAHTCGNPVRLVAGGGPLLQGATMSEKRAHFLREYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDFAILFIETSGCLP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 103 MCGHAVLALGRFALDFGLVPAPPAGtreaRVNIHCPCGLVTAFVACEDGRSHGpVRFHSVPAFVLATDLMVDVPGHGKVM 182
Cdd:PRK13971   89 MCGHGTIGTVTAAIEEGLVTPKTPG----KLRLDTPAGLVDIEYEQDGEKVES-VRLTNVPSYLAAEDLEVEIPGLGPLK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 183 VDIAYGGAFYAFVTAEK--LGLDICSAKtrDLVDAASAVTEAVKAQFKINHPDSEDLAFLYGTILTDgkDAYTKEPTTNI 260
Cdd:PRK13971  164 VDVAYGGNFYAIVEPQEnfPGLDHYSAS--DILRWSPVLRQALNEKYEFVHPEDPRIRGVSHVLWTG--KPISPGADARN 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462538700 261 CVFA-DEQVDRSPTGSGVTARIALQYHKGLLELNQmrAF-KSSATGSVFTGK 310
Cdd:PRK13971  240 AVFYgDKAIDRSPCGTGTSARMAQLAAKGKLKVGD--EFvHESIIGSLFEGR 289
PRK13970 PRK13970
4-hydroxyproline epimerase;
20-313 5.33e-32

4-hydroxyproline epimerase;


Pssm-ID: 172473  Cd Length: 311  Bit Score: 121.28  E-value: 5.33e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700  20 LSVVDMHTGGEPLRIVLAGCPEVSGPTLLAKRRYMRQHLDHVRRRLMFEPRGHRDMYGAVLVPSELPDAHLGVLFLHNEG 99
Cdd:PRK13970    5 IQIIDSHTGGEPTRLVVSGFPSLGGGTMAERRDVLAREHDRYRTACILEPRGSDVLVGALLCEPVSPDAAAGVIFFNNSG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 100 YSSMCGHAVLALGRFALDFGLVpaPPAGTRearvnIHCPCGLVTAfvACEDGRShgpVRFHSVPAFVLATDLMVDVPGHG 179
Cdd:PRK13970   85 YLGMCGHGTIGVVRTLHHMGRI--GPGVHR-----IETPVGTVEA--TLHDDLS---VSVRNVLAYRHAKDVVVDVPGYG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538700 180 KVMVDIAYGGAFYAFVTAEklGLDICSAKTRDLVDAASAVTEAVKAQfkinhpdsedlaflyGTILTDGKdaytkePTTN 259
Cdd:PRK13970  153 PVKGDIAWGGNWFFLISDH--GQRVAGDNVAALTAYASAVRAGLERA---------------GITGANGG------EIDH 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462538700 260 ICVFADE--------------QVDRSPTGSGVTARIALQYHKGLLELNQMRAfKSSATGSVFTGKAVR 313
Cdd:PRK13970  210 IELFADDpehdsrsfvlcpghAYDRSPCGTGTSAKLACLAADGKLAPGVVWR-QASVIGSVFSASYAA 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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