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Conserved domains on  [gi|2462539238|ref|XP_054231552|]
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tubulinyl-Tyr carboxypeptidase 1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vasohibin super family cl20733
Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible ...
 1-120 4.45e-77

Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.


The actual alignment was detected with superfamily member pfam14822:

Pssm-ID: 434242  Cd Length: 245  Bit Score: 230.32  E-value: 4.45e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539238   1 MPTLERFPISFKTYFSGNYFRHIVLGVNFAGRYGALGMSRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQS 80
Cdd:pfam14822 126 YPNLERFPISFKSQFSGHHFRHIVLGVHHNGRYGALGLSRRQDLMYKPLTFRTLSDLIFDFEDSYEKYWHTLKKVKIGLY 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462539238  81 VSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERHARDMR 120
Cdd:pfam14822 206 VPHDPHSCQPIEWKHLVLNVSKLGREDLRKELEKHSRDMR 245
 
Name Accession Description Interval E-value
Vasohibin pfam14822
Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible ...
 1-120 4.45e-77

Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.


Pssm-ID: 434242  Cd Length: 245  Bit Score: 230.32  E-value: 4.45e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539238   1 MPTLERFPISFKTYFSGNYFRHIVLGVNFAGRYGALGMSRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQS 80
Cdd:pfam14822 126 YPNLERFPISFKSQFSGHHFRHIVLGVHHNGRYGALGLSRRQDLMYKPLTFRTLSDLIFDFEDSYEKYWHTLKKVKIGLY 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462539238  81 VSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERHARDMR 120
Cdd:pfam14822 206 VPHDPHSCQPIEWKHLVLNVSKLGREDLRKELEKHSRDMR 245
 
Name Accession Description Interval E-value
Vasohibin pfam14822
Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible ...
 1-120 4.45e-77

Vasohibin; This family of proteins function as angiogenesis inhibitors in animals. Reversible detyrosination of alpha-tubulin is crucial to microtubule dynamics and functions and defects have been implicated in cancer, brain disorganization, and cardiomyopathies. VASH1 and its homolog VASH2, when complexed with SVBP, exhibited robust and specific Tyr/Phe carboxypeptidase activity on microtubules.


Pssm-ID: 434242  Cd Length: 245  Bit Score: 230.32  E-value: 4.45e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462539238   1 MPTLERFPISFKTYFSGNYFRHIVLGVNFAGRYGALGMSRREDLMYKPPAFRTLSELVLDFEAAYGRCWHVLKKVKLGQS 80
Cdd:pfam14822 126 YPNLERFPISFKSQFSGHHFRHIVLGVHHNGRYGALGLSRRQDLMYKPLTFRTLSDLIFDFEDSYEKYWHTLKKVKIGLY 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462539238  81 VSHDPHSVEQIEWKHSVLDVERLGRDDFRKELERHARDMR 120
Cdd:pfam14822 206 VPHDPHSCQPIEWKHLVLNVSKLGREDLRKELEKHSRDMR 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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