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Conserved domains on  [gi|2462541620|ref|XP_054232707|]
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basal body-orientation factor 1 isoform X3 [Homo sapiens]

Protein Classification

BBOF1/CCDC121 family protein( domain architecture ID 12171747)

BBOF1/CCDC121 family protein is a DUF4515 domain-containing protein; similar to Homo sapiens basal body-orientation factor 1 and coiled-coil domain-containing protein 121

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 77-270 2.17e-53

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


:

Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 180.35  E-value: 2.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  77 DIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRK 156
Cdd:pfam14988   1 ENKFFLEYLAKKTEEKQKKIEKLWNQYVQECEEIERRRQELASRYTQQTAELQTQLLQKEKEQASLKKELQALRPFAKLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 157 IQVERELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQEA-EKKIIMLAERAHHE-----------AIVQLNDAGRN 224
Cdd:pfam14988  81 ESQEREIQDLEEEKEKVRAETAEKDREAHLQFLKEKALLEKQLqELRILELGERATRElkrkaqalklaAKQALSEFCRS 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2462541620 225 VFKENVYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEINDLL 270
Cdd:pfam14988 161 IKRENRQLQKELLQLIQETQALEAIKSKLENRKQRLKEEQWYLEAL 206
 
Name Accession Description Interval E-value
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 77-270 2.17e-53

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 180.35  E-value: 2.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  77 DIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRK 156
Cdd:pfam14988   1 ENKFFLEYLAKKTEEKQKKIEKLWNQYVQECEEIERRRQELASRYTQQTAELQTQLLQKEKEQASLKKELQALRPFAKLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 157 IQVERELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQEA-EKKIIMLAERAHHE-----------AIVQLNDAGRN 224
Cdd:pfam14988  81 ESQEREIQDLEEEKEKVRAETAEKDREAHLQFLKEKALLEKQLqELRILELGERATRElkrkaqalklaAKQALSEFCRS 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2462541620 225 VFKENVYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEINDLL 270
Cdd:pfam14988 161 IKRENRQLQKELLQLIQETQALEAIKSKLENRKQRLKEEQWYLEAL 206
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 82-374 1.53e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620   82 LSYLKKQDQEKDNMIEKLKQQLNETKEKaQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVER 161
Cdd:TIGR02168  227 LALLVLRLEELREELEELQEELKEAEEE-LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  162 ELDDLKENLRNTERIHQETLRRLESRfFEEKHRLEQEAEKKIIMLAERahHEAIVQLNDAGRNVFKEnvylqKALAYHLK 241
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESK-LDELAEELAELEEKLEELKEE--LESLEAELEELEAELEE-----LESRLEEL 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  242 ETDALQKNSQKLQESHTLLLHQKEIndllvkekimqlVQQRSQIQTLQKKVVNLETalsymtkEFESEVLKLQQHAMIEN 321
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEI------------ERLEARLERLEDRRERLQQ-------EIEELLKKLEEAELKEL 438

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462541620  322 QAGQVEIDKLQHLLQMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQI 374
Cdd:TIGR02168  439 QAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 22-256 1.54e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 1.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  22 IKTDESVVDRAKANASLWEARLEVTELSRIKYRDTSQILAKSNEDLKKKQCKMEKDIMSV---LSYLKKQDQEKDNMIEK 98
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLeerRRELEERLEELEEELAE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  99 LKQQLNETKEK---AQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTER 175
Cdd:COG1196   328 LEEELEELEEEleeLEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEE 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 176 IHQETLRRLESRffeEKHRLEQEAEKKIIMLAERAHHEAIVQLNDAGRNVFKENVYLQKALAYHLKETDALQKNSQKLQE 255
Cdd:COG1196   408 AEEALLERLERL---EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLE 484


                  .
gi 2462541620 256 S 256
Cdd:COG1196   485 E 485
PTZ00121 PTZ00121
MAEBL; Provisional
 31-379 9.83e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 9.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620   31 RAKANASLWEARLE-VTELSRIKYRDTSQILAKSNED-LKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKE 108
Cdd:PTZ00121  1582 KAEEAKKAEEARIEeVMKLYEEEKKMKAEEAKKAEEAkIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKI 1661

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  109 KAQEEKDKLEQ--KYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERElddlKENLRNTERIHQETLRRLES 186
Cdd:PTZ00121  1662 KAAEEAKKAEEdkKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK----AEELKKAEEENKIKAEEAKK 1737

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  187 RFFEEKHRLEQ----EAEKKIIMLAERAHHEAIVQLNDAGRNVFKENVYLQ--KALAYHLKETDALQKNSQKLQESHT-- 258
Cdd:PTZ00121  1738 EAEEDKKKAEEakkdEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEdeKRRMEVDKKIKDIFDNFANIIEGGKeg 1817

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  259 --LLLHQKEINDLLVKEKIMQLVQQRSQIQTLQKKVVNLETALSYMT-KEFESEVLKLQQHAMIENQAGQVEIDKLQHLL 335
Cdd:PTZ00121  1818 nlVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGnKEADFNKEKDLKEDDEEEIEEADEIEKIDKDD 1897

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462541620  336 QMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQIL-ISRK 379
Cdd:PTZ00121  1898 IEREIPNNNMAGKNNDIIDDKLDKDEYIKRDAEETREEIIkISKK 1942
 
Name Accession Description Interval E-value
DUF4515 pfam14988
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ...
 77-270 2.17e-53

Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.


Pssm-ID: 405647 [Multi-domain]  Cd Length: 206  Bit Score: 180.35  E-value: 2.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  77 DIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRK 156
Cdd:pfam14988   1 ENKFFLEYLAKKTEEKQKKIEKLWNQYVQECEEIERRRQELASRYTQQTAELQTQLLQKEKEQASLKKELQALRPFAKLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 157 IQVERELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQEA-EKKIIMLAERAHHE-----------AIVQLNDAGRN 224
Cdd:pfam14988  81 ESQEREIQDLEEEKEKVRAETAEKDREAHLQFLKEKALLEKQLqELRILELGERATRElkrkaqalklaAKQALSEFCRS 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2462541620 225 VFKENVYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEINDLL 270
Cdd:pfam14988 161 IKRENRQLQKELLQLIQETQALEAIKSKLENRKQRLKEEQWYLEAL 206
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 82-374 1.53e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620   82 LSYLKKQDQEKDNMIEKLKQQLNETKEKaQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVER 161
Cdd:TIGR02168  227 LALLVLRLEELREELEELQEELKEAEEE-LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  162 ELDDLKENLRNTERIHQETLRRLESRfFEEKHRLEQEAEKKIIMLAERahHEAIVQLNDAGRNVFKEnvylqKALAYHLK 241
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESK-LDELAEELAELEEKLEELKEE--LESLEAELEELEAELEE-----LESRLEEL 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  242 ETDALQKNSQKLQESHTLLLHQKEIndllvkekimqlVQQRSQIQTLQKKVVNLETalsymtkEFESEVLKLQQHAMIEN 321
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEI------------ERLEARLERLEDRRERLQQ-------EIEELLKKLEEAELKEL 438

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462541620  322 QAGQVEIDKLQHLLQMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQI 374
Cdd:TIGR02168  439 QAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARL 491
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 22-256 1.54e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 1.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  22 IKTDESVVDRAKANASLWEARLEVTELSRIKYRDTSQILAKSNEDLKKKQCKMEKDIMSV---LSYLKKQDQEKDNMIEK 98
Cdd:COG1196   248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLeerRRELEERLEELEEELAE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  99 LKQQLNETKEK---AQEEKDKLEQKYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTER 175
Cdd:COG1196   328 LEEELEELEEEleeLEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEE 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 176 IHQETLRRLESRffeEKHRLEQEAEKKIIMLAERAHHEAIVQLNDAGRNVFKENVYLQKALAYHLKETDALQKNSQKLQE 255
Cdd:COG1196   408 AEEALLERLERL---EEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLE 484


                  .
gi 2462541620 256 S 256
Cdd:COG1196   485 E 485
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 22-339 3.42e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 50.12  E-value: 3.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620   22 IKTDESVVDRAKANASLWEARLEVTELSRIKYRDTSQILAKSNEDLKKKQCKMeKDIMSVLSYLKKQDQEKDNMIEKLKQ 101
Cdd:pfam15921  491 LESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL-RNVQTECEALKLQMAEKDKVIEILRQ 569

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  102 QL-NETK--------------EKAQEEKD------------KLEQKYTRQINELEGQFH----QKAKEIGMIHTELKAVR 150
Cdd:pfam15921  570 QIeNMTQlvgqhgrtagamqvEKAQLEKEindrrlelqefkILKDKKDAKIRELEARVSdlelEKVKLVNAGSERLRAVK 649

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  151 QFQKRKIQVERELDD--------------LKENLRNTERIHQETLRRLESRFFEEKHRLEQEAEKKIIMLAERAHheaiv 216
Cdd:pfam15921  650 DIKQERDQLLNEVKTsrnelnslsedyevLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGH----- 724

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  217 qlndagrnVFKENVYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEindlLVKEKIMQLVQQ--------------- 281
Cdd:pfam15921  725 --------AMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKH----FLKEEKNKLSQElstvateknkmagel 792

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462541620  282 ---RSQIQTLQKKVVNLETALSYMTKEFEsevlklQQHAMIENQAGQVEIDKLQHLLQMKD 339
Cdd:pfam15921  793 evlRSQERRLKEKVANMEVALDKASLQFA------ECQDIIQRQEQESVRLKLQHTLDVKE 847
PTZ00121 PTZ00121
MAEBL; Provisional
 31-379 9.83e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 9.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620   31 RAKANASLWEARLE-VTELSRIKYRDTSQILAKSNED-LKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKE 108
Cdd:PTZ00121  1582 KAEEAKKAEEARIEeVMKLYEEEKKMKAEEAKKAEEAkIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKI 1661

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  109 KAQEEKDKLEQ--KYTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERElddlKENLRNTERIHQETLRRLES 186
Cdd:PTZ00121  1662 KAAEEAKKAEEdkKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKK----AEELKKAEEENKIKAEEAKK 1737

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  187 RFFEEKHRLEQ----EAEKKIIMLAERAHHEAIVQLNDAGRNVFKENVYLQ--KALAYHLKETDALQKNSQKLQESHT-- 258
Cdd:PTZ00121  1738 EAEEDKKKAEEakkdEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEdeKRRMEVDKKIKDIFDNFANIIEGGKeg 1817

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  259 --LLLHQKEINDLLVKEKIMQLVQQRSQIQTLQKKVVNLETALSYMT-KEFESEVLKLQQHAMIENQAGQVEIDKLQHLL 335
Cdd:PTZ00121  1818 nlVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGnKEADFNKEKDLKEDDEEEIEEADEIEKIDKDD 1897

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462541620  336 QMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQIL-ISRK 379
Cdd:PTZ00121  1898 IEREIPNNNMAGKNNDIIDDKLDKDEYIKRDAEETREEIIkISKK 1942
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 104-317 1.26e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 104 NETKEKAQEEKDKLEQkytrQINELEGQFHQKAKEIGMIHTELKAVRQ---FQKRKIQV-ERELDDLKENLRNTERIHQE 179
Cdd:COG4942    19 ADAAAEAEAELEQLQQ----EIAELEKELAALKKEEKALLKQLAALERriaALARRIRAlEQELAALEAELAELEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 180 TLRRLESRFFEEKHRLeqeaeKKIIMLAERAHHEAIVQLNDAGRnVFKENVYLQKALAYHLKETDALQKNSQKLQESHTL 259
Cdd:COG4942    95 LRAELEAQKEELAELL-----RALYRLGRQPPLALLLSPEDFLD-AVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462541620 260 LLHQKEIndllVKEKIMQLVQQRSQIQTLQKKVVNLETALSYMTKEFESEVLKLQQHA 317
Cdd:COG4942   169 LEAERAE----LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA 222
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 90-388 2.18e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.16  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  90 QEKDNMIEKLKQQLnETKEKAQEEKDKLEQkytRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERELDDLKEN 169
Cdd:COG1196   196 GELERQLEPLERQA-EKAERYRELKEELKE---LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEE 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 170 LRNTERIHQETLRRLESRFFEEKHRLEQEaEKKIIMLAERAHH--EAIVQLNDAGRNvfkenvyLQKALAYHLKETDALQ 247
Cdd:COG1196   272 LRLELEELELELEEAQAEEYELLAELARL-EQDIARLEERRREleERLEELEEELAE-------LEEELEELEEELEELE 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 248 KNSQKLQESHTLLLHQKEINDLLVKEKIMQLVQQRSQIQTLQKKVVNLETAlsymtkefESEVLKLQQHAMIENQAGQVE 327
Cdd:COG1196   344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA--------AAELAAQLEELEEAEEALLER 415

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462541620 328 IDKLQHLLQMKDREMNRVKKLAKNILDERTEVERFFLDALHQVKQQILISRKHYKQIAQAA 388
Cdd:COG1196   416 LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE 476
PLN02939 PLN02939
transferase, transferring glycosyl groups
 42-373 2.78e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.12  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  42 RLEVTELSRIKYRDTSQILAKSNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKY 121
Cdd:PLN02939   47 KKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLRTVMELPQKSTSSDDDHNRASMQRDEAIAAIDNEQQTNSKDGEQLS 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 122 TRQINELegqfhqkakeIGMIHTELKAVRQFQKRKIQVereLDDLKENLRNTERIHQEtLRRLESRFFEEKHRLEQEAEK 201
Cdd:PLN02939  127 DFQLEDL----------VGMIQNAEKNILLLNQARLQA---LEDLEKILTEKEALQGK-INILEMRLSETDARIKLAAQE 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 202 KIIM-----LAERAHHEAIVQLNDAGRNVF----------KENVYLQ------KALAYHLKETDalqKNSQKLQESHTLL 260
Cdd:PLN02939  193 KIHVeileeQLEKLRNELLIRGATEGLCVHslskeldvlkEENMLLKddiqflKAELIEVAETE---ERVFKLEKERSLL 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 261 ---LHQKEINDLLVKEKIMQLVQQrsQIQTLQKKVVNLETALSYMTKEFESEVLKLQQHAMIENQAGQVE---------- 327
Cdd:PLN02939  270 dasLRELESKFIVAQEDVSKLSPL--QYDCWWEKVENLQDLLDRATNQVEKAALVLDQNQDLRDKVDKLEaslkeanvsk 347

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462541620 328 -----IDKLQH-------LLQMKDREMNRVKKLAKNILDErteverfFLDALHQVKQQ 373
Cdd:PLN02939  348 fssykVELLQQklklleeRLQASDHEIHSYIQLYQESIKE-------FQDTLSKLKEE 398
DUF4618 pfam15397
Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins ...
 52-256 2.87e-04

Domain of unknown function (DUF4618); This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.


Pssm-ID: 464704 [Multi-domain]  Cd Length: 258  Bit Score: 42.63  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  52 KYRDTSQILAKSNEDLKKKQCKMEKDIMSVLSYLKKQdQEKDNMIEKLKQQLNETK-EKAQEEKDKLEQKYTRQINELEG 130
Cdd:pfam15397  10 ELKKHEDFLTKLNLELIKAIQDTEDSTALKVRKLLQQ-YEKFGTIISILEYSNKKQlQQAKAELQEWEEKEESKLNKLEQ 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620 131 QFHQKAKEIGMIHTEL-------------KAV------RQFQKRKIQVERELDDLkenlrntERIHQETLRRLESRFFEE 191
Cdd:pfam15397  89 QLEQLNAKIQKTQEELnflstykdkeypvKAVqianlvRQLQQLKDSQQDELDEL-------EEMRRMVLESLSRKIQKK 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462541620 192 KHRLEQEAEKKIIMlaerAHHEAIVQLNDAGRNVFKENVYLQKALAYHLKETDALQKNSQKLQES 256
Cdd:pfam15397 162 KEKILSSLAEKTLS----PYQESLLQKTRDNQVMLKEIEQFREFIDELEEEIPKLKAEVQQLQAQ 222
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 54-201 1.56e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  54 RDTSQILAKSNEDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQE-EKDKLEQKYTRQINELEGQF 132
Cdd:pfam17380 420 VEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLElEKEKRDRKRAEEQRRKILEK 499

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462541620 133 HQKAKEIGMIHTElkavrqfQKRKIqVERELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQEAEK 201
Cdd:pfam17380 500 ELEERKQAMIEEE-------RKRKL-LEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRK 560
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 42-355 1.71e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.59  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620   42 RLEVTELSRIKYRDTSQIL--AKSNEDLKKKQcKMEKDIMSVLSYLKKQDQEkdnmIEKLKQQLNETKEKAQEEKDKLEQ 119
Cdd:TIGR02169  202 RLRREREKAERYQALLKEKreYEGYELLKEKE-ALERQKEAIERQLASLEEE----LEKLTEEISELEKRLEEIEQLLEE 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  120 kYTRQINEL-EGQFHQKAKEIGMIHTELKAVRQFQKRKiqvERELDDLKENLRNTErihqETLRRLESRFFEEKHRLEQE 198
Cdd:TIGR02169  277 -LNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEK---ERELEDAEERLAKLE----AEIDKLLAEIEELEREIEEE 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  199 AEKKIIMLAErahheaIVQLNDAGRNVFKENVYLQKALAYHLKETDALQKNSQKLQESHTLLLHQKEINDLLVKEKIMQL 278
Cdd:TIGR02169  349 RKRRDKLTEE------YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEEL 422

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  279 VQQRSQIQTLQKKVVNLETALSYMTKEFESEVLKLQQHAMI------ENQAGQVEIDKLQHLLQMKDREMNRVKKLAKNI 352
Cdd:TIGR02169  423 ADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADlskyeqELYDLKEEYDRVEKELSKLQRELAEAEAQARAS 502


                   ...
gi 2462541620  353 LDE 355
Cdd:TIGR02169  503 EER 505
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 135-374 2.44e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  135 KAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTERIHQETLRRLES---------RFFEEKHRLEqEAEKKIIM 205
Cdd:TIGR02168  153 KPEERRAIFEEAAGISKYKERRKETERKLERTRENLDRLEDILNELERQLKSlerqaekaeRYKELKAELR-ELELALLV 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  206 LAERAHHEAIVQLNDAgrnvFKENVYLQKALAYHLKETDAL--QKNSQKLQESHTLLLHQKEINDL--LVKEKIMQLVQQ 281
Cdd:TIGR02168  232 LRLEELREELEELQEE----LKEAEEELEELTAELQELEEKleELRLEVSELEEEIEELQKELYALanEISRLEQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  282 RSQIQTLQKKVVNLETALsymTKEFESEVLKLQQHAMIENQAGQVEIDKLQHLLQMKdrEMNRVKKLAKNILDERTEVER 361
Cdd:TIGR02168  308 RERLANLERQLEELEAQL---EELESKLDELAEELAELEEKLEELKEELESLEAELE--ELEAELEELESRLEELEEQLE 382

                          250
                   ....*....|...
gi 2462541620  362 FFLDALHQVKQQI 374
Cdd:TIGR02168  383 TLRSKVAQLELQI 395
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 42-342 4.31e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 39.95  E-value: 4.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620   42 RLEVTELSRIKYRDTSQILAKSNEDLKKKQCKMEK--DIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQ 119
Cdd:pfam02463  728 QEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKeeEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALE 807

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  120 KyTRQINELEGQFHQKAKEIGMIHTELKAVRQFQKRKIQVERELDDLKENLRNTERIHQETLRRLESrffEEKHRLEQEA 199
Cdd:pfam02463  808 E-ELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELL---LKEEELEEQK 883

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  200 EKKIIMLAERAHHEaivQLNDAGRNVFKENVYLQKALAYHLKETDALQKNSQKLQESHTLLLhqkEINDLLVKEKIMQLV 279
Cdd:pfam02463  884 LKDELESKEEKEKE---EKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLL---EEADEKEKEENNKEE 957

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462541620  280 QQRSQIQTLQKKVvnLETALSYMTKEFESEVLKLQQHAMIENQAGQVEIDKLQHLLQMKDREM 342
Cdd:pfam02463  958 EEERNKRLLLAKE--ELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 65-199 6.54e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 39.11  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541620  65 EDLKKKQCKMEKDIMSVLSYLKKQDQEKDNMIEKLKQQLNETKEKAQEEKDKLEQKYTRQ--INELEGQFHQKAKEIGMI 142
Cdd:pfam07888  69 EQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEarIRELEEDIKTLTQRVLER 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462541620 143 HTELKAVRQFQKRKIQVERELDDLKENLRNTERIHQETLRRLESRFFEEKHRLEQEA 199
Cdd:pfam07888 149 ETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRD 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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