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Conserved domains on  [gi|2462544805|ref|XP_054234260|]
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membrane progestin receptor gamma isoform X4 [Homo sapiens]

Protein Classification

AdipoR/hemolysin III family protein( domain architecture ID 2520)

AdipoR/hemolysin III family protein similar to adiponectin receptors (AdipoRs), which are integral membrane proteins that control glucose and lipid metabolism by mediating cellular ceramidase activity

PubMed:  28329765

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HlyIII super family cl03831
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 68-158 6.55e-21

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


The actual alignment was detected with superfamily member pfam03006:

Pssm-ID: 470885  Cd Length: 222  Bit Score: 86.94  E-value: 6.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544805  68 RLCKVIRVLAFAYPYTWDSLPIFYRLFLFPG-ESAQNEATSYHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLF 146
Cdd:pfam03006 131 PAPRWLRTAVYILMGWSGIIPIAHRALALGGaGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIF 210

                          90
                  ....*....|..
gi 2462544805 147 HVCVILATHMQM 158
Cdd:pfam03006 211 HVFVVLAALCHY 222
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 68-158 6.55e-21

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 86.94  E-value: 6.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544805  68 RLCKVIRVLAFAYPYTWDSLPIFYRLFLFPG-ESAQNEATSYHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLF 146
Cdd:pfam03006 131 PAPRWLRTAVYILMGWSGIIPIAHRALALGGaGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIF 210

                          90
                  ....*....|..
gi 2462544805 147 HVCVILATHMQM 158
Cdd:pfam03006 211 HVFVVLAALCHY 222
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 68-158 6.55e-21

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 86.94  E-value: 6.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462544805  68 RLCKVIRVLAFAYPYTWDSLPIFYRLFLFPG-ESAQNEATSYHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLF 146
Cdd:pfam03006 131 PAPRWLRTAVYILMGWSGIIPIAHRALALGGaGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIF 210

                          90
                  ....*....|..
gi 2462544805 147 HVCVILATHMQM 158
Cdd:pfam03006 211 HVFVVLAALCHY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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