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Conserved domains on  [gi|2462545977|ref|XP_054234827|]
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thrombospondin type-1 domain-containing protein 4 isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 62-177 4.96e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 125.77  E-value: 4.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545977  62 VVSGVFKHALtSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 140
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462545977 141 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 177
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 505-561 1.48e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 1.48e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462545977 505 WFAGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPSECSFLEKPPSQQSCHLKPC 561
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 329-385 1.05e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 1.05e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462545977 329 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 385
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 388-442 1.69e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.69e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977 388 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDVVDDEECNMKLRPNDIENCDMGPC 442
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 624-654 2.09e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.00  E-value: 2.09e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462545977 624 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 654
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 565-616 1.27e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 1.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462545977 565 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTLSNLCDPQLKPEERESCNPQDC 616
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 1-60 5.66e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 54.33  E-value: 5.66e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977   1 MGYRFYVRQAEKVIDGTPCDQNGT------AICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGC 60
Cdd:pfam19236  50 IGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 276-325 3.28e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 3.28e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462545977 276 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPtPEEEPCNIFPC 325
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 446-499 7.81e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 7.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977 446 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPAEATPCDNGPC 499
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 62-177 4.96e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 125.77  E-value: 4.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545977  62 VVSGVFKHALtSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 140
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462545977 141 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 177
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 505-561 1.48e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 1.48e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462545977 505 WFAGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPSECSFLEKPPSQQSCHLKPC 561
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 329-385 1.05e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 1.05e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462545977 329 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 385
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 388-442 1.69e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.69e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977 388 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDVVDDEECNMKLRPNDIENCDMGPC 442
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 624-654 2.09e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.00  E-value: 2.09e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462545977 624 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 654
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 565-616 1.27e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 1.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462545977 565 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTLSNLCDPQLKPEERESCNPQDC 616
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 1-60 5.66e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 54.33  E-value: 5.66e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977   1 MGYRFYVRQAEKVIDGTPCDQNGT------AICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGC 60
Cdd:pfam19236  50 IGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 276-325 3.28e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 3.28e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462545977 276 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPtPEEEPCNIFPC 325
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 446-499 7.81e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 7.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977 446 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPAEATPCDNGPC 499
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 385-442 1.21e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.21e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462545977  385 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDvVDDEECNMKLRpnDIENCDMGPC 442
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 568-616 3.89e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462545977  568 TEWSMCSKSCQGGFRVREVRCLSDDMTLS-NLCDPQLKpeERESCNPQDC 616
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 329-352 4.93e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 4.93e-04
                           10        20
                   ....*....|....*....|....
gi 2462545977  329 WDIGEWSECSKTCGLGMQHRQVLC 352
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 508-561 4.94e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 4.94e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462545977  508 GSWSQCSIECGSGTQQREVICVRKNADtfevLDPSECSflEKPPSQQSCHLKPC 561
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 62-177 4.96e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 125.77  E-value: 4.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462545977  62 VVSGVFKHALtSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpneiS 140
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462545977 141 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 177
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 505-561 1.48e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 65.55  E-value: 1.48e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462545977 505 WFAGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPSECSFLEKPPSQQSCHLKPC 561
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 329-385 1.05e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 1.05e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462545977 329 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 385
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 388-442 1.69e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.69  E-value: 1.69e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977 388 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDVVDDEECNMKLRPNDIENCDMGPC 442
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 624-654 2.09e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.00  E-value: 2.09e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462545977 624 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 654
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 565-616 1.27e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.38  E-value: 1.27e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462545977 565 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTLSNLCDPQLKPEERESCNPQDC 616
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 1-60 5.66e-09

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 54.33  E-value: 5.66e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977   1 MGYRFYVRQAEKVIDGTPCDQNGT------AICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGC 60
Cdd:pfam19236  50 IGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 276-325 3.28e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 50.14  E-value: 3.28e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462545977 276 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPtPEEEPCNIFPC 325
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 446-499 7.81e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.60  E-value: 7.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462545977 446 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPAEATPCDNGPC 499
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 385-442 1.21e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.21e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462545977  385 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDvVDDEECNMKLRpnDIENCDMGPC 442
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 568-616 3.89e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462545977  568 TEWSMCSKSCQGGFRVREVRCLSDDMTLS-NLCDPQLKpeERESCNPQDC 616
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGgGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 329-352 4.93e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.34  E-value: 4.93e-04
                           10        20
                   ....*....|....*....|....
gi 2462545977  329 WDIGEWSECSKTCGLGMQHRQVLC 352
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP_1 pfam00090
Thrombospondin type 1 domain;
386-442 5.76e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.17  E-value: 5.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462545977 386 SEWqirTDWTSCSVPCGVGQRTRDVKCVSNigdVVDDEECNMKLRPNDIenCDMGPC 442
Cdd:pfam00090   1 SPW---SPWSPCSVTCGKGIQVRQRTCKSP---FPGGEPCTGDDIETQA--CKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 332-365 1.20e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462545977 332 GEWSECSKTCGLGMQHRQvlcrqvyanRSLTVQP 365
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRT---------RTVIVEP 31
TSP_1 pfam00090
Thrombospondin type 1 domain;
332-352 1.94e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.63  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|.
gi 2462545977 332 GEWSECSKTCGLGMQHRQVLC 352
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTC 24
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 508-561 4.94e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 4.94e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462545977  508 GSWSQCSIECGSGTQQREVICVRKNADtfevLDPSECSflEKPPSQQSCHLKPC 561
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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