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Conserved domains on  [gi|2462547060|ref|XP_054235349|]
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cadherin-16 isoform X2 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-375 1.56e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 272 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 350
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 2462547060 351 DlaGAEGGFSSTCEVEVAVTDINDH 375
Cdd:cd11304    76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 194-262 2.14e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.14e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462547060 194 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 262
Cdd:cd11304    28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-585 8.17e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 498 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 573
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                          90
                  ....*....|..
gi 2462547060 574 PRLSASAPLVIH 585
Cdd:cd11304    80 PPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 60-164 5.30e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060  60 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 139
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                          90       100
                  ....*....|....*....|....*
gi 2462547060 140 LVQVKDMGDQAsgHQATATVEVSII 164
Cdd:cd11304    71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 387-488 6.04e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 387 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 466
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                          90       100
                  ....*....|....*....|....*..
gi 2462547060 467 kLV-----GPGPGPGATATVTVLVERV 488
Cdd:cd11304    70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-51 7.31e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.31e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462547060   1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 51
Cdd:cd11304    47 IDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-375 1.56e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 272 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 350
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 2462547060 351 DlaGAEGGFSSTCEVEVAVTDINDH 375
Cdd:cd11304    76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 194-262 2.14e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.14e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462547060 194 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 262
Cdd:cd11304    28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 194-264 2.95e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.95e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547060  194 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 264
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-585 8.17e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 498 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 573
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                          90
                  ....*....|..
gi 2462547060 574 PRLSASAPLVIH 585
Cdd:cd11304    80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 289-377 2.62e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 2.62e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060  289 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 366
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 2462547060  367 VAVTDINDHAP 377
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 60-164 5.30e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060  60 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 139
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                          90       100
                  ....*....|....*....|....*
gi 2462547060 140 LVQVKDMGDQAsgHQATATVEVSII 164
Cdd:cd11304    71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 387-488 6.04e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 387 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 466
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                          90       100
                  ....*....|....*....|....*..
gi 2462547060 467 kLV-----GPGPGPGATATVTVLVERV 488
Cdd:cd11304    70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
271-370 1.90e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 271 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 2462547060 349 AMDLAGaeGGFSSTCEVEVAVT 370
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-51 7.31e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.31e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462547060   1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 51
Cdd:cd11304    47 IDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1-54 7.38e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 7.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462547060    1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 54
Cdd:smart00112  28 IDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
386-486 2.41e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 386 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 465
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 2462547060 466 AKLVGPGPGPGATATVTVLVE 486
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-164 1.87e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060   80 ASDRDEPgtANSDLRFHILSQAPaqpsPDMFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATV 159
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 2462547060  160 EVSII 164
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
202-256 1.04e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547060 202 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 256
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
61-164 3.34e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060  61 YRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQLL 140
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 2462547060 141 VQVKDMGDQASghQATATVEVSII 164
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1-46 1.38e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 1.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462547060   1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHV 46
Cdd:pfam00028  46 IDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 272-375 1.56e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 272 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 350
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 2462547060 351 DlaGAEGGFSSTCEVEVAVTDINDH 375
Cdd:cd11304    76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 194-262 2.14e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.14e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462547060 194 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 262
Cdd:cd11304    28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 194-264 2.95e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.95e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547060  194 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 264
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-585 8.17e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 498 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 573
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                          90
                  ....*....|..
gi 2462547060 574 PRLSASAPLVIH 585
Cdd:cd11304    80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 289-377 2.62e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 2.62e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060  289 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 366
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 2462547060  367 VAVTDINDHAP 377
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 60-164 5.30e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060  60 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 139
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                          90       100
                  ....*....|....*....|....*
gi 2462547060 140 LVQVKDMGDQAsgHQATATVEVSII 164
Cdd:cd11304    71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 387-488 6.04e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 387 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 466
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                          90       100
                  ....*....|....*....|....*..
gi 2462547060 467 kLV-----GPGPGPGATATVTVLVERV 488
Cdd:cd11304    70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
271-370 1.90e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 271 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 348
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 2462547060 349 AMDLAGaeGGFSSTCEVEVAVT 370
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-51 7.31e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.31e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462547060   1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 51
Cdd:cd11304    47 IDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1-54 7.38e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 7.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462547060    1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 54
Cdd:smart00112  28 IDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
386-486 2.41e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060 386 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 465
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 2462547060 466 AKLVGPGPGPGATATVTVLVE 486
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-164 1.87e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060   80 ASDRDEPgtANSDLRFHILSQAPaqpsPDMFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATV 159
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 2462547060  160 EVSII 164
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
202-256 1.04e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547060 202 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 256
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
61-164 3.34e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547060  61 YRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQLL 140
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 2462547060 141 VQVKDMGDQASghQATATVEVSII 164
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 206-262 8.12e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 8.12e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547060 206 PPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 262
Cdd:cd00031    41 LPSWLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
1-46 1.38e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 1.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462547060   1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHV 46
Cdd:pfam00028  46 IDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1-51 1.54e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.48  E-value: 1.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462547060   1 MDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 51
Cdd:cd00031    47 WEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDEND 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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