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Conserved domains on  [gi|2462547235|ref|XP_054235433|]
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ataxin-2-like protein isoform X29 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
103-176 1.57e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.57e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547235  103 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 176
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
244-306 1.49e-17

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.49e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547235  244 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 306
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
316-898 2.67e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  316 GRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGP-----------GSEARGINGG 384
Cdd:PHA03247  2513 SRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrpaprpsepavTSRARRPDAP 2592
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  385 PSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRmyPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSV 464
Cdd:PHA03247  2593 PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  465 SDPGVGSISPASPKISLAPTDVpglqneqkrfqleelrkfgaqfklqpsSSPENSLDPFPPrilkeepkgkekevdgllt 544
Cdd:PHA03247  2671 GRAAQASSPPQRPRRRAARPTV---------------------------GSLTSLADPPPP------------------- 2704
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  545 sepmgspvssktesvsdkEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLikgedkdeGPVAEQVKKSTLNPNAKEFNP 624
Cdd:PHA03247  2705 ------------------PPTPEPAPHALVSATPLPPGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPA 2758
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  625 TKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAK 704
Cdd:PHA03247  2759 RPPT------TAGPPAPAP-----PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  705 GSLPPQRSDQHQPASAPPmmqaaaaagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLT 782
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPG----------------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLA 2887
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  783 SGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGS 862
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAV 2959
                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 2462547235  863 GQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFPQP 898
Cdd:PHA03247  2960 PQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTPPL 2996
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
103-176 1.57e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.57e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547235  103 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 176
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
244-306 1.49e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.49e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547235  244 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 306
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
316-898 2.67e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  316 GRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGP-----------GSEARGINGG 384
Cdd:PHA03247  2513 SRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrpaprpsepavTSRARRPDAP 2592
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  385 PSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRmyPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSV 464
Cdd:PHA03247  2593 PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  465 SDPGVGSISPASPKISLAPTDVpglqneqkrfqleelrkfgaqfklqpsSSPENSLDPFPPrilkeepkgkekevdgllt 544
Cdd:PHA03247  2671 GRAAQASSPPQRPRRRAARPTV---------------------------GSLTSLADPPPP------------------- 2704
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  545 sepmgspvssktesvsdkEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLikgedkdeGPVAEQVKKSTLNPNAKEFNP 624
Cdd:PHA03247  2705 ------------------PPTPEPAPHALVSATPLPPGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPA 2758
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  625 TKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAK 704
Cdd:PHA03247  2759 RPPT------TAGPPAPAP-----PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  705 GSLPPQRSDQHQPASAPPmmqaaaaagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLT 782
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPG----------------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLA 2887
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  783 SGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGS 862
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAV 2959
                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 2462547235  863 GQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFPQP 898
Cdd:PHA03247  2960 PQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTPPL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
785-947 4.14e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 4.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  785 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 862
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  863 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 942
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350

                   ....*
gi 2462547235  943 QVMLL 947
Cdd:pfam09770  351 QLAQL 355
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
103-176 1.57e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 83.76  E-value: 1.57e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547235  103 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVMLVHFR 176
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
244-306 1.49e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.49e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462547235  244 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 306
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
316-898 2.67e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  316 GRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGP-----------GSEARGINGG 384
Cdd:PHA03247  2513 SRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrpaprpsepavTSRARRPDAP 2592
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  385 PSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRmyPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSV 464
Cdd:PHA03247  2593 PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP--SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL 2670
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  465 SDPGVGSISPASPKISLAPTDVpglqneqkrfqleelrkfgaqfklqpsSSPENSLDPFPPrilkeepkgkekevdgllt 544
Cdd:PHA03247  2671 GRAAQASSPPQRPRRRAARPTV---------------------------GSLTSLADPPPP------------------- 2704
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  545 sepmgspvssktesvsdkEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLikgedkdeGPVAEQVKKSTLNPNAKEFNP 624
Cdd:PHA03247  2705 ------------------PPTPEPAPHALVSATPLPPGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPA 2758
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  625 TKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAK 704
Cdd:PHA03247  2759 RPPT------TAGPPAPAP-----PAAPA-AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  705 GSLPPQRSDQHQPASAPPmmqaaaaagpplvaatPYSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLT 782
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPG----------------PPPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLA 2887
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  783 SGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATqlhahQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGS 862
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAV 2959
                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 2462547235  863 GQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFPQP 898
Cdd:PHA03247  2960 PQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTPPL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
785-947 4.14e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 4.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  785 SHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQL--HAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGS 862
Cdd:pfam09770  217 APAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVP 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  863 GQPQQNLYHPgaltgtppSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVtQAHvqtgitaappphpgaphPP 942
Cdd:pfam09770  297 VQPTQILQNP--------NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITH-----------------PQ 350

                   ....*
gi 2462547235  943 QVMLL 947
Cdd:pfam09770  351 QLAQL 355
PHA03247 PHA03247
large tegument protein UL36; Provisional
345-972 4.78e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 4.78e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  345 RCSSSRGGRPGLSSLPPRGPhhldNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVgrm 424
Cdd:PHA03247  2487 RFPFAAGAAPDPGGGGPPDP----DAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAA--- 2559
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  425 yPPRSPKSAAPAPISASCP-EPPIGS-----AVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVPGLQNEQKRFQL 498
Cdd:PHA03247  2560 -PPAAPDRSVPPPRPAPRPsEPAVTSrarrpDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  499 EELRKFGAQFKLQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVS--DKEDKPPLAPSGGTEG 576
Cdd:PHA03247  2639 DPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADppPPPPTPEPAPHALVSA 2718
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  577 PEQPPPPCPSQTGSPPVGLikgedkdeGPVAEQVKKSTLNPNAKEFNPTKPLlsvnksTSTPTSPGPrthstPSIPVlTA 656
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPARPPT------TAGPPAPAP-----PAAPA-AG 2778
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  657 GQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVA 736
Cdd:PHA03247  2779 PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  737 ATPYSSYIPynPQQFPGQPAMMqpmAHYPSQPVFAPMLQSNPRMLTSGSHPQAivssSTPQYPSAEQPTPQALYATVHQS 816
Cdd:PHA03247  2859 GGDVRRRPP--SRSPAAKPAAP---ARPPVRRLARPAVSRSTESFALPPDQPE----RPPQPQAPPPPQPQPQPPPPPQP 2929
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  817 YPHHATQLHAHQPQPATTPTGSQPQSQHAAPSP----VQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPpGPSAQSPQ 892
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgaLVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHS-LSRVSSWA 3008
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  893 SSF-------PQPAAVYAIHHQQLPHGFTNMAHVTQAHVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSG 965
Cdd:PHA03247  3009 SSLalheetdPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFG 3088

                   ....*..
gi 2462547235  966 VPALSAS 972
Cdd:PHA03247  3089 PPPLSAN 3095
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
608-872 1.24e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 49.26  E-value: 1.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  608 EQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPrthSTPSIPVLTagqsGLYSPQYISYIPQIH-------MGPAVQ 680
Cdd:pfam09770   98 EQVRFNRQQPAARAAQSSAQPPASSLPQYQYASQQS---QQPSKPVRT----GYEKYKEPEPIPDLQvdaslwgVAPKKA 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  681 APQMYPYPVSNSVPGQQGKYRG--------AKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFP 752
Cdd:pfam09770  171 AAPAPAPQPAAQPASLPAPSRKmmsleeveAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQP 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  753 GQPAMMQPMAHYPSQpvfapmLQsnpRMlTSGSHPQAIVSSSTPQYPSAEQPTPQalyatvhqsyPHHATQLHAHQPQPA 832
Cdd:pfam09770  251 QQPQQHPGQGHPVTI------LQ---RP-QSPQPDPAQPSIQPQAQQFHQQPPPV----------PVQPTQILQNPNRLS 310
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2462547235  833 TTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQnLYHP 872
Cdd:pfam09770  311 AARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPI-ITHP 349
PHA03247 PHA03247
large tegument protein UL36; Provisional
624-993 2.79e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 2.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  624 PTKPLLSVNKSTSTPTSPGPrTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQ-QGKYRG 702
Cdd:PHA03247  2595 SARPRAPVDDRGDPRGPAPP-SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRaRRLGRA 2673
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  703 AKGSLPPQRSdqHQPASAPPMMQAAAAAGPPLVAATPYssyiPYNPQQFPGQPAMMQPMAHYPSQPVfAPMLQSNPRMLT 782
Cdd:PHA03247  2674 AQASSPPQRP--RRRAARPTVGSLTSLADPPPPPPTPE----PAPHALVSATPLPPGPAAARQASPA-LPAAPAPPAVPA 2746
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  783 SGSHPQAIVSSSTPQYPSA-EQPTPQALYATVhqsyPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPhlG 861
Cdd:PHA03247  2747 GPATPGGPARPARPPTTAGpPAPAPPAAPAAG----PPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALP--P 2820
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  862 SGQPQQNLYHPGALTGTPPSLPPGPSAQS------------------PQSSFPQPAAVYAIHHQQLPHGFTNMAHVTQAH 923
Cdd:PHA03247  2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL 2900
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  924 VQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHPQGEQPGQAPG 993
Cdd:PHA03247  2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
PRK10263 PRK10263
DNA translocase FtsK; Provisional
617-897 3.07e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.16  E-value: 3.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  617 PNAKEFNP-------TKPLLSVNKSTS-TPTSPGPRTHSTPSIPVLTAgQSGLYSPQY-ISYIPQIHMGPAVQAPQMYPY 687
Cdd:PRK10263   302 PEYDEYDPllngapiTEPVAVAAAATTaTQSWAAPVEPVTQTPPVASV-DVPPAQPTVaWQPVPGPQTGEPVIAPAPEGY 380
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  688 PvsnsvPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQqfPGQPAMMQPMAHYPSQ 767
Cdd:PRK10263   381 P-----QQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA--PEQPVAGNAWQAEEQQ 453
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  768 PVFAPmlqsNPRMLTSGSHPQAIVSSSTPQYPSAEQPT-----------------PQALYATVHQSYPHHATQLHA-HQ- 828
Cdd:PRK10263   454 STFAP----QSTYQTEQTYQQPAAQEPLYQQPQPVEQQpvvepepvveetkparpPLYYFEEVEEKRAREREQLAAwYQp 529
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462547235  829 -PQPATTP---TGSQPQSQHAAPSPVQHQAGQAPhLGSGQPQQNLYHPGALTGTPPSLPP----GPSAQSPQSSFPQ 897
Cdd:PRK10263   530 iPEPVKEPepiKSSLKAPSVAAVPPVEAAAAVSP-LASGVKKATLATGAAATVAAPVFSLansgGPRPQVKEGIGPQ 605
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
747-964 4.23e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 4.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  747 NPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSG----SHPQAI----VSSS------TPQYPSAEQPTPQALYAT 812
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyekyKEPEPIpdlqVDASlwgvapKKAAAPAPAPQPAAQPAS 185
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  813 VHQSYPHHAT------QLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPP-- 884
Cdd:pfam09770  186 LPAPSRKMMSleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVti 265
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  885 --GPSAQSPQSSFPQPAAVYAIHHQQLPhgfTNMAHVTQA-------HVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGG 955
Cdd:pfam09770  266 lqRPQSPQPDPAQPSIQPQAQQFHQQPP---PVPVQPTQIlqnpnrlSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQ 342

                   ....*....
gi 2462547235  956 PPQGAVPQS 964
Cdd:pfam09770  343 APIITHPQQ 351
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
826-901 1.11e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 1.11e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547235  826 AHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 901
Cdd:PRK14971   389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
354-652 1.73e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  354 PGLSSLPPRGPHHLDNSS----PGPGSEARGINGGPSRMSP----KAQRPLRGAKTLSSP--SNRPSGETSVPPPPavgR 423
Cdd:PTZ00449   514 PEASGLPPKAPGDKEGEEgeheDSKESDEPKEGGKPGETKEgevgKKPGPAKEHKPSKIPtlSKKPEFPKDPKHPK---D 590
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  424 MYPPRSPKS--AAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPGVGS--ISPASPKISLAPTDVPGLQNEQKRFQLE 499
Cdd:PTZ00449   591 PEEPKKPKRprSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQrpSSPERPEGPKIIKSPKPPKSPKPPFDPK 670
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  500 ELRKFGAQFKLQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMG-SPVSSKTESVSDKEDKPPLAPSggtegpe 578
Cdd:PTZ00449   671 FKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPlPPKLPRDEEFPFEPIGDPDAEQ------- 743
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  579 qpppPCPSQTGSPPVG---LIKGEDKDE---GPVAEQVKKSTLNPNAKEfnPTKPLLSVNKSTS-TPTSPGprTHstPSI 651
Cdd:PTZ00449   744 ----PDDIEFFTPPEEertFFHETPADTplpDILAEEFKEEDIHAETGE--PDEAMKRPDSPSEhEDKPPG--DH--PSL 813

                   .
gi 2462547235  652 P 652
Cdd:PTZ00449   814 P 814
PRK10927 PRK10927
cell division protein FtsN;
797-900 3.87e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 43.90  E-value: 3.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  797 QYPSAEQpTPQALYATVH-QSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGAL 875
Cdd:PRK10927   138 EVPWNEQ-TPEQRQQTLQrQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAH 216
                           90       100
                   ....*....|....*....|....*.
gi 2462547235  876 TGTPPSLP-PGPSAQSPQSsfPQPAA 900
Cdd:PRK10927   217 TTAQSKPQqAAPVTRAADA--PKPTA 240
PRK10263 PRK10263
DNA translocase FtsK; Provisional
749-898 5.15e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 5.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  749 QQFPG-QPAMMQPMAHypSQPVFAPMlqsnPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAH 827
Cdd:PRK10263   709 QRYSGeQPAGANPFSL--DDFEFSPM----KALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQ 782
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462547235  828 QPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPgaltgTPPSLPPGPSAQSPQSSFPQP 898
Cdd:PRK10263   783 QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ-----PQYQQPQQPVAPQPQDTLLHP 848
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
614-872 5.27e-04

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 43.92  E-value: 5.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  614 TLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYipQIHMGPAVQAPQMYPYPvsnsv 693
Cdd:pfam03326  310 TLVPIAGSTGVTEVVSYGHNSTSPSSTPCPSTAVTEADHQTEPEVPWIATAHQESD--QRPIGPGPEKPTFLPPV----- 382
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  694 pgqqGKYRGAKGsLPPQRSDQHQPAsappmmQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPammqpmahypsqpvfapm 773
Cdd:pfam03326  383 ----GGKQFFQG-LRDSRSTSFLTA------PEATSAISDVFQGTEVCQPKRIRALHPPGSP------------------ 433
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  774 lqSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYAT--VHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQ 851
Cdd:pfam03326  434 --SANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDAApvATPEASHELQPPDEETPQPLDEDQALCGQQDASHPPPRG 511
                          250       260
                   ....*....|....*....|.
gi 2462547235  852 HQAGQAPHLGSGQPQQNLYHP 872
Cdd:pfam03326  512 QLDELTTTLESMTEDLNLDSP 532
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
353-752 8.44e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 8.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  353 RPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRMYPPRSPKS 432
Cdd:PHA03307    64 RFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGS 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  433 AAPAPisasCPEPPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVPGLQNeqkrfqlEELRKFGAQFKLQP 512
Cdd:PHA03307   144 PGPPP----AASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTP-------PAAASPRPPRRSSP 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  513 SSSPENSLDPFPPRilkEEPKGKEKEVDGLLTSEPMGSPVSSKTESvSDKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPP 592
Cdd:PHA03307   213 ISASASSPAPAPGR---SAADDAGASSSDSSSSESSGCGWGPENEC-PLPRPAPITLPTRIWEASGWNGPSSRPGPASSS 288
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  593 VGlIKGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPllSVNKSTSTPTSPGPRTHSTPSipvltaGQSGLYSPQYISYIPQ 672
Cdd:PHA03307   289 SS-PRERSPSPSPSSPGSGPAPSSPRASSSSSSSR--ESSSSSTSSSSESSRGAAVSP------GPSPSRSPSPSRPPPP 359
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  673 IHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFP 752
Cdd:PHA03307   360 ADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSGEP 439
PHA03247 PHA03247
large tegument protein UL36; Provisional
308-476 2.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  308 SAVQRQGSGRESPSLASREGKYIPLPQRVREGPRggvrcsSSRGGRPGLSSLPPRGPHH-------------LDNSSPGP 374
Cdd:PHA03247  2633 PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR------ARRLGRAAQASSPPQRPRRraarptvgsltslADPPPPPP 2706
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  375 GSEARGINGGPSRMSPKAQRPLRGAK--TLSSPSNRPSGETSVPP--PPAVGRMYPPRSPKSAAPAPISASCPEP----P 446
Cdd:PHA03247  2707 TPEPAPHALVSATPLPPGPAAARQASpaLPAAPAPPAVPAGPATPggPARPARPPTTAGPPAPAPPAAPAAGPPRrltrP 2786
                          170       180       190
                   ....*....|....*....|....*....|
gi 2462547235  447 IGSAVPTSSASIPVTSSVSDPGVGSISPAS 476
Cdd:PHA03247  2787 AVASLSESRESLPSPWDPADPPAAVLAPAA 2816
PHA03247 PHA03247
large tegument protein UL36; Provisional
301-487 4.07e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 4.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  301 RTEEEKHSAVQRQGSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARG 380
Cdd:PHA03247  2649 PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  381 INGGPSRMSPKAQRPLRGAKTLSSPSNRPSGE--TSVPPPPAvgrmyPPRSPKSAAP--APISASCPEPPIGSAVPTSSA 456
Cdd:PHA03247  2729 RQASPALPAAPAPPAVPAGPATPGGPARPARPptTAGPPAPA-----PPAAPAAGPPrrLTRPAVASLSESRESLPSPWD 2803
                          170       180       190
                   ....*....|....*....|....*....|.
gi 2462547235  457 SIPVTSSVSDPGVGSISPASPKISLAPTDVP 487
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
624-901 4.88e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  624 PTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIsyiPQIHmGPAVQAPQMYPYPVSNSVPGQQGKYRGA 703
Cdd:pfam03154  199 PTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPH-PPLQPMTQPPPPSQVSPQPLPQPSLHGQ 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  704 KGSLPP--QRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM------QPMAHYPSQPVFAPMLQ 775
Cdd:pfam03154  275 MPPMPHslQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQsqlqsqQPPREQPLPPAPLSMPH 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  776 SNPRMLT---------SGSHPQAIVSSSTPQYPSAEQPTPQ----ALYATVHQSYPHHATQLHAHQPQPATTPTGSQP-- 840
Cdd:pfam03154  355 IKPPPTTpipqlpnpqSHKHPPHLSGPSPFQMNSNLPPPPAlkplSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPvl 434
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547235  841 -QSQHAAPSPVQHQAGQAPHLGSGQ---PQQNLYHPGALTGTPPSLPPG-----------PSAQSPQSSFPQPAAV 901
Cdd:pfam03154  435 tQSQSLPPPAASHPPTSGLHQVPSQspfPQHPFVPGGPPPITPPSGPPTstssampgiqpPSSASVSSSGPVPAAV 510
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
374-488 5.60e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 5.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  374 PGSEARGINGGPSRMSPKAQRPLRGAKTLSSPsnRPSGETSVPPPPAVGRMYPPRSP-----KSAAPAPISASCPEPPIG 448
Cdd:PRK14951   374 APAEKKTPARPEAAAPAAAPVAQAAAAPAPAA--APAAAASAPAAPPAAAPPAPVAApaaaaPAAAPAAAPAAVALAPAP 451
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462547235  449 SAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVPG 488
Cdd:PRK14951   452 PAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPT 491
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
307-468 6.76e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 6.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  307 HSAVQRQGSGRESPSLASREGKyIPLPQRVREGPRGGVRcssSRGGRPGLSSLPPRGPHhldnSSPGPGSEARGINGGPS 386
Cdd:PHA03307   241 SSESSGCGWGPENECPLPRPAP-ITLPTRIWEASGWNGP---SSRPGPASSSSSPRERS----PSPSPSSPGSGPAPSSP 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  387 RMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRMYPPRSPKS-AAPAPISASCPEPPIGSAVPTSSASIPVTSSVS 465
Cdd:PHA03307   313 RASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPpADPSSPRKRPRPSRAPSSPAASAGRPTRRRARA 392

                   ...
gi 2462547235  466 DPG 468
Cdd:PHA03307   393 AVA 395
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
632-992 7.46e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 7.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  632 NKSTStPTSPGPR-----THSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGkyrgAKGS 706
Cdd:pfam03154  141 NRSTS-PSIPSPQdnesdSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS----PATS 215
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  707 LPPQrsdQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQ---PAMMQPMAHYPSQPVFAPmLQSNPRMLTS 783
Cdd:pfam03154  216 QPPN---QTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQvspQPLPQPSLHGQMPPMPHS-LQTGPSHMQH 291
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  784 GSHPQAIvsSSTPQYPSAEQPTPQALYAtvhqsyPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSG 863
Cdd:pfam03154  292 PVPPQPF--PLTPQSSQSQVPPGPSPAA------PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPI 363
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547235  864 QP---QQNLYHPGALTGTPP-----SLPPgPSAQSPQSSFP--QPAAVYAIHHQQLPHGFTNMAHVTQAHVQTgiTAAPP 933
Cdd:pfam03154  364 PQlpnPQSHKHPPHLSGPSPfqmnsNLPP-PPALKPLSSLSthHPPSAHPPPLQLMPQSQQLPPPPAQPPVLT--QSQSL 440
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462547235  934 PHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHPQGEQPGQAP 992
Cdd:pfam03154  441 PPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSAS 499
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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