NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462547741|ref|XP_054235679|]
View 

zinc finger protein ZFPM1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 119-228 1.42e-58

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


:

Pssm-ID: 380992  Cd Length: 110  Bit Score: 196.15  E-value: 1.42e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  119 WSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEI 198
Cdd:cd19215      1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGQAEESPAVTLLLVDEDCWLRRLPLVSTEAEANCTI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462547741  199 HRKDDALWCRVTKPVPAGGLLSVLLTAEPH 228
Cdd:cd19215     81 YRKGDAIWCKTTKPVPEGELLSAILVTEPQ 110
PRK12495 super family cl32772
hypothetical protein; Provisional
 443-554 5.47e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PRK12495:

Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 42.55  E-value: 5.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  443 QGPLASADLGLAPTPSPGLDRNALAEATNGEARAAPQNGGSSEPPAAPRSikveaveEPEAAPILGPGEPGPQAPSRTPS 522
Cdd:PRK12495    80 DGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEAATD-------PPATAAARDGPTPDPTAQPATPD 152

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462547741  523 PRSPAPARVKAELSSPTPGSSPVPGELGLAGA 554
Cdd:PRK12495   153 ERRSPRQRPPVSGEPPTPSTPDAHVAGTLQAA 184
PHA00733 super family cl26169
hypothetical protein
 352-407 2.90e-03

hypothetical protein


The actual alignment was detected with superfamily member PHA00733:

Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 2.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547741  352 PFVCLICLSAFTTKANCERHLKVHTDTLsgVCHSCGFISTTRDILYSHLVTNHMVC 407
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVCKKHNIC 126
 
Name Accession Description Interval E-value
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 119-228 1.42e-58

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 196.15  E-value: 1.42e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  119 WSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEI 198
Cdd:cd19215      1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGQAEESPAVTLLLVDEDCWLRRLPLVSTEAEANCTI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462547741  199 HRKDDALWCRVTKPVPAGGLLSVLLTAEPH 228
Cdd:cd19215     81 YRKGDAIWCKTTKPVPEGELLSAILVTEPQ 110
PRK12495 PRK12495
hypothetical protein; Provisional
 443-554 5.47e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 42.55  E-value: 5.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  443 QGPLASADLGLAPTPSPGLDRNALAEATNGEARAAPQNGGSSEPPAAPRSikveaveEPEAAPILGPGEPGPQAPSRTPS 522
Cdd:PRK12495    80 DGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEAATD-------PPATAAARDGPTPDPTAQPATPD 152

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462547741  523 PRSPAPARVKAELSSPTPGSSPVPGELGLAGA 554
Cdd:PRK12495   153 ERRSPRQRPPVSGEPPTPSTPDAHVAGTLQAA 184
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 461-555 2.01e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.91  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  461 LDRNALAEATNGEARAAPQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPTP 540
Cdd:NF041121    15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94

                           90
                   ....*....|....*
gi 2462547741  541 GSSPVPGELGLAGAL 555
Cdd:NF041121    95 APPALPNPLELARAL 109
PHA00733 PHA00733
hypothetical protein
 352-407 2.90e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 2.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547741  352 PFVCLICLSAFTTKANCERHLKVHTDTLsgVCHSCGFISTTRDILYSHLVTNHMVC 407
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVCKKHNIC 126
 
Name Accession Description Interval E-value
PR-SET_ZFPM1 cd19215
PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed ...
 119-228 1.42e-58

PR-SET domain found in zinc finger protein ZFPM1 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation.


Pssm-ID: 380992  Cd Length: 110  Bit Score: 196.15  E-value: 1.42e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  119 WSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEI 198
Cdd:cd19215      1 WNGPDELELVGSSGQRRVRARQSLSEGLSWGPYHGSIQSSASSPGQAEESPAVTLLLVDEDCWLRRLPLVSTEAEANCTI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462547741  199 HRKDDALWCRVTKPVPAGGLLSVLLTAEPH 228
Cdd:cd19215     81 YRKGDAIWCKTTKPVPEGELLSAILVTEPQ 110
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 119-228 1.75e-20

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 88.17  E-value: 1.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  119 WSGPDELE----PVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPA--------LTLLLVDEACWLRTLP 186
Cdd:cd19201      1 LSLPGELElrkpSQDAGRSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYEWKVEAqgskggegLLLLTEDSGTWLKLVR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2462547741  187 QALTEAEANTEIHRKDDALWCRVTKPVPAGGLLSVLLTAEPH 228
Cdd:cd19201     81 SADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPLL 122
PR-SET_ZFPM2 cd19216
PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed ...
 119-216 7.31e-12

PR-SET domain found in zinc finger protein ZFPM2 and similar proteins; ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380993  Cd Length: 111  Bit Score: 62.98  E-value: 7.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  119 WSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPaltLLLVDEACWLRTLP-QALTEAEANTE 197
Cdd:cd19216      1 WDGPGELEVFQKDGERKIHSRQQLPVGTTWGPFPGKIDLNNNSLKTKAPVP---LVLTAGPKWLLDVTwQGTEDNKNNCI 77

                           90
                   ....*....|....*....
gi 2462547741  198 IHRKDDALWCRVTKPVPAG 216
Cdd:cd19216     78 VYSKGGQLWCTTTKNISEG 96
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 122-221 2.40e-08

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 52.20  E-value: 2.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  122 PDELEPVVQD---GQRRIRARLSLATGLSWGPFHGSVqtrassprqaepspaltlllvdeaCWLRTLPQALTEAEANTEI 198
Cdd:cd10534      2 PAGLELVLSSipeGGLGVFARRTIPAGTRFGPLEGVV------------------------NWMRFVRPARNEEEQNLVA 57

                           90       100
                   ....*....|....*....|...
gi 2462547741  199 HRKDDALWCRVTKPVPAGGLLSV 221
Cdd:cd10534     58 YQHGGQIYFRTTRDIPPGEELLV 80
PRK12495 PRK12495
hypothetical protein; Provisional
 443-554 5.47e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 42.55  E-value: 5.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  443 QGPLASADLGLAPTPSPGLDRNALAEATNGEARAAPQNGGSSEPPAAPRSikveaveEPEAAPILGPGEPGPQAPSRTPS 522
Cdd:PRK12495    80 DGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEAATD-------PPATAAARDGPTPDPTAQPATPD 152

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462547741  523 PRSPAPARVKAELSSPTPGSSPVPGELGLAGA 554
Cdd:PRK12495   153 ERRSPRQRPPVSGEPPTPSTPDAHVAGTLQAA 184
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 429-571 6.88e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 6.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  429 PDSLGSFQQQHTALQGPLASADLGLAPTPSPGLDRNALAEATNGEARAAPQNGGSSEPPAAPrsikvEAVEEPEAAPilg 508
Cdd:PRK07764   368 SDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAP-----QPAPAPAPAP--- 439

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462547741  509 pgepgPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPAS 571
Cdd:PRK07764   440 -----APPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAP 497
PHA03247 PHA03247
large tegument protein UL36; Provisional
 454-571 1.51e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  454 APTPSPGLDRNALAEATNGEARAAPQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKA 533
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAV 2788

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462547741  534 ELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPAS 571
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 461-555 2.01e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 41.91  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  461 LDRNALAEATNGEARAAPQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPTP 540
Cdd:NF041121    15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVP 94

                           90
                   ....*....|....*
gi 2462547741  541 GSSPVPGELGLAGAL 555
Cdd:NF041121    95 APPALPNPLELARAL 109
PHA00733 PHA00733
hypothetical protein
 352-407 2.90e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 2.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462547741  352 PFVCLICLSAFTTKANCERHLKVHTDTLsgVCHSCGFISTTRDILYSHLVTNHMVC 407
Cdd:PHA00733    73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHVCKKHNIC 126
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
445-572 4.53e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 4.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  445 PLASADLGLAPTPSPGLDRNALAEATNGEARAAPQNGGSSEPPAAPRSIKVEAVEEPEAAPilgpgEPGPQAPSRTPSPR 524
Cdd:PRK12323   407 AAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAA-----GPRPVAAAAAAAPA 481

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462547741  525 SPAPARVKAELSSPTPGSSPVPGELGLAGalflpqyVFGPDAAPPASE 572
Cdd:PRK12323   482 RAAPAAAPAPADDDPPPWEELPPEFASPA-------PAQPDAAPAGWV 522
PHA03247 PHA03247
large tegument protein UL36; Provisional
 418-570 9.35e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 9.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  418 PGAGHPATKLPPDSLGSFQQQHTALQGPLASADLGLAPTPSpGLDRNALAEATNGEARAAPQNGGSSEPP---------- 487
Cdd:PHA03247  2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPAPPAAPAAGPPrrltrpavas 2790

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462547741  488 AAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAA 567
Cdd:PHA03247  2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRS 2870


                   ...
gi 2462547741  568 PPA 570
Cdd:PHA03247  2871 PAA 2873
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH