NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462548718|ref|XP_054236158|]
View 

general transcription factor 3C polypeptide 1 isoform X2 [Homo sapiens]

Protein Classification

B-block_TFIIIC and Tau138_eWH domain-containing protein( domain architecture ID 12050989)

B-block_TFIIIC and Tau138_eWH domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
B-block_TFIIIC pfam04182
B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit ...
 174-250 1.30e-24

B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding.


:

Pssm-ID: 367858  Cd Length: 75  Bit Score: 98.86  E-value: 1.30e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462548718  174 PDFSYCILERLGRSRWQGELQRDLHTtAFKVDAGKLHYHRKILNKNGLITMQSHvIRLPTGAQQHSILLLLNRFHVD 250
Cdd:pfam04182    1 GALQFCLLEEIARSRYNGITQSDLAK-LTGQDPRSLHYRLKKLEKKGLIVKQQI-IQSNTGKSIHTSLLVLPRFAID 75
Tau138_eWH cd16169
extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits ...
 611-707 2.78e-23

extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits of the tauB subcomplex of yeast transcription factor IIIC. This extended winged-helix domain of tau138 appears to interact with the TPR (tetratricopeptide repeat) array of tauA subunit tau131, and may therefore play a role in linking tauA, tauB, and TFIIIB to regulate the formation of the RNA polymerase III pre-initiation complex.


:

Pssm-ID: 320085  Cd Length: 97  Bit Score: 96.11  E-value: 2.78e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548718  611 TYRLLKRRNLIIEAVTNLRLIesLFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQ--DGIKKKV 688
Cdd:cd16169      1 SLRSLRRENEILEVLKELGGV--VNLEKKFLEEHEKLLGSLTRMDKKTLKRDLNKLEEEGKLKVITTSVPAvgDGRSRTV 78

                           90
                   ....*....|....*....
gi 2462548718  689 DLVVHPSMDQNDPLVRSAI 707
Cdd:cd16169     79 LYLPDPSVEPLDPLLLSLI 97
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 1766-1869 3.11e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548718 1766 REDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTqmtPAKRPALQDSNLAPSLGPGAEDGAEAQ 1845
Cdd:PRK07764   412 PAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAA---PSAQPAPAPAAAPEPTAAPAPAPPAAP 488

                           90       100
                   ....*....|....*....|....
gi 2462548718 1846 APSPPPALEDTAAAGAAQEDQEGV 1869
Cdd:PRK07764   489 APAAAPAAPAAPAAPAGADDAATL 512
 
Name Accession Description Interval E-value
B-block_TFIIIC pfam04182
B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit ...
 174-250 1.30e-24

B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding.


Pssm-ID: 367858  Cd Length: 75  Bit Score: 98.86  E-value: 1.30e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462548718  174 PDFSYCILERLGRSRWQGELQRDLHTtAFKVDAGKLHYHRKILNKNGLITMQSHvIRLPTGAQQHSILLLLNRFHVD 250
Cdd:pfam04182    1 GALQFCLLEEIARSRYNGITQSDLAK-LTGQDPRSLHYRLKKLEKKGLIVKQQI-IQSNTGKSIHTSLLVLPRFAID 75
Tau138_eWH cd16169
extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits ...
 611-707 2.78e-23

extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits of the tauB subcomplex of yeast transcription factor IIIC. This extended winged-helix domain of tau138 appears to interact with the TPR (tetratricopeptide repeat) array of tauA subunit tau131, and may therefore play a role in linking tauA, tauB, and TFIIIB to regulate the formation of the RNA polymerase III pre-initiation complex.


Pssm-ID: 320085  Cd Length: 97  Bit Score: 96.11  E-value: 2.78e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548718  611 TYRLLKRRNLIIEAVTNLRLIesLFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQ--DGIKKKV 688
Cdd:cd16169      1 SLRSLRRENEILEVLKELGGV--VNLEKKFLEEHEKLLGSLTRMDKKTLKRDLNKLEEEGKLKVITTSVPAvgDGRSRTV 78

                           90
                   ....*....|....*....
gi 2462548718  689 DLVVHPSMDQNDPLVRSAI 707
Cdd:cd16169     79 LYLPDPSVEPLDPLLLSLI 97
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1766-1869 3.11e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548718 1766 REDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTqmtPAKRPALQDSNLAPSLGPGAEDGAEAQ 1845
Cdd:PRK07764   412 PAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAA---PSAQPAPAPAAAPEPTAAPAPAPPAAP 488

                           90       100
                   ....*....|....*....|....
gi 2462548718 1846 APSPPPALEDTAAAGAAQEDQEGV 1869
Cdd:PRK07764   489 APAAAPAAPAAPAAPAGADDAATL 512
 
Name Accession Description Interval E-value
B-block_TFIIIC pfam04182
B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit ...
 174-250 1.30e-24

B-block binding subunit of TFIIIC; Yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding.


Pssm-ID: 367858  Cd Length: 75  Bit Score: 98.86  E-value: 1.30e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462548718  174 PDFSYCILERLGRSRWQGELQRDLHTtAFKVDAGKLHYHRKILNKNGLITMQSHvIRLPTGAQQHSILLLLNRFHVD 250
Cdd:pfam04182    1 GALQFCLLEEIARSRYNGITQSDLAK-LTGQDPRSLHYRLKKLEKKGLIVKQQI-IQSNTGKSIHTSLLVLPRFAID 75
Tau138_eWH cd16169
extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits ...
 611-707 2.78e-23

extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits of the tauB subcomplex of yeast transcription factor IIIC. This extended winged-helix domain of tau138 appears to interact with the TPR (tetratricopeptide repeat) array of tauA subunit tau131, and may therefore play a role in linking tauA, tauB, and TFIIIB to regulate the formation of the RNA polymerase III pre-initiation complex.


Pssm-ID: 320085  Cd Length: 97  Bit Score: 96.11  E-value: 2.78e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548718  611 TYRLLKRRNLIIEAVTNLRLIesLFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQ--DGIKKKV 688
Cdd:cd16169      1 SLRSLRRENEILEVLKELGGV--VNLEKKFLEEHEKLLGSLTRMDKKTLKRDLNKLEEEGKLKVITTSVPAvgDGRSRTV 78

                           90
                   ....*....|....*....
gi 2462548718  689 DLVVHPSMDQNDPLVRSAI 707
Cdd:cd16169     79 LYLPDPSVEPLDPLLLSLI 97
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1766-1869 3.11e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462548718 1766 REDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTqmtPAKRPALQDSNLAPSLGPGAEDGAEAQ 1845
Cdd:PRK07764   412 PAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAA---PSAQPAPAPAAAPEPTAAPAPAPPAAP 488

                           90       100
                   ....*....|....*....|....
gi 2462548718 1846 APSPPPALEDTAAAGAAQEDQEGV 1869
Cdd:PRK07764   489 APAAAPAAPAAPAAPAGADDAATL 512
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH