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Conserved domains on  [gi|2470707909|ref|XP_054543764|]
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leucine-rich repeat-containing protein 63 isoform X3 [Talpa occidentalis]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
346-487 4.38e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 4.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 346 SLKGFFISNCPDLTPLAfQLVYIDLSFNHISSFPTEVFCVKYLQVLILRNNPIKEIPSAIEQLKYLRIFNIAFNFITTLP 425
Cdd:COG4886    97 NLTELDLSGNEELSNLT-NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2470707909 426 PGFFSLSHLEKVDLSYNSIDFIPNEIQKLRSLTKLAINGNDLRSFPPGILML-NLKKIQFENN 487
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNN 238
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
346-487 4.38e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 4.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 346 SLKGFFISNCPDLTPLAfQLVYIDLSFNHISSFPTEVFCVKYLQVLILRNNPIKEIPSAIEQLKYLRIFNIAFNFITTLP 425
Cdd:COG4886    97 NLTELDLSGNEELSNLT-NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2470707909 426 PGFFSLSHLEKVDLSYNSIDFIPNEIQKLRSLTKLAINGNDLRSFPPGILML-NLKKIQFENN 487
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
411-467 3.69e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.69e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2470707909 411 LRIFNIAFNFITTLPPG-FFSLSHLEKVDLSYNSIDFI-PNEIQKLRSLTKLAINGNDL 467
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 401-487 1.14e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.90  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 401 IPSAIEQLKYLRIFNIAFNFIT-TLPPGFFSLSHLEKVDLSYNSID-FIPNEIQKLRSLTKLAINGNDLRSFPPGIL--- 475
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALggr 513

                          90
                  ....*....|..
gi 2470707909 476 MLNLKKIQFENN 487
Cdd:PLN03150  514 LLHRASFNFTDN 525
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 370-473 4.91e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 370 LSFN--HISSFPTEVFCvKYLQVLILRNNPIKEIP--SAIEQLKYLRIFNiafNFITTLPpGFFSLSHLEKVDLSYNSID 445
Cdd:cd21340     7 LYLNdkNITKIDNLSLC-KNLKVLYLYDNKITKIEnlEFLTNLTHLYLQN---NQIEKIE-NLENLVNLKKLYLGGNRIS 81

                          90       100
                  ....*....|....*....|....*...
gi 2470707909 446 FIPNeIQKLRSLTKLAINGNDLrsfPPG 473
Cdd:cd21340    82 VVEG-LENLTNLEELHIENQRL---PPG 105
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
346-487 4.38e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 4.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 346 SLKGFFISNCPDLTPLAfQLVYIDLSFNHISSFPTEVFCVKYLQVLILRNNPIKEIPSAIEQLKYLRIFNIAFNFITTLP 425
Cdd:COG4886    97 NLTELDLSGNEELSNLT-NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLP 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2470707909 426 PGFFSLSHLEKVDLSYNSIDFIPNEIQKLRSLTKLAINGNDLRSFPPGILML-NLKKIQFENN 487
Cdd:COG4886   176 EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
343-487 1.85e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 1.85e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 343 NALSLKGFFISNCPDLTplafqlvYIDLSFNHISSFPTEVFCVKYLQVLILRNNPIKEIPSAIEQLKYLRIFNIAFNFIT 422
Cdd:COG4886   123 NQLTDLPEELANLTNLK-------ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2470707909 423 TLPPGFFSLSHLEKVDLSYNSIDFIPNEIQKLRSLTKLAINGNDLRSFPPGILMLNLKKIQFENN 487
Cdd:COG4886   196 DLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
411-467 3.69e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.69e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2470707909 411 LRIFNIAFNFITTLPPG-FFSLSHLEKVDLSYNSIDFI-PNEIQKLRSLTKLAINGNDL 467
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 401-487 1.14e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.90  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 401 IPSAIEQLKYLRIFNIAFNFIT-TLPPGFFSLSHLEKVDLSYNSID-FIPNEIQKLRSLTKLAINGNDLRSFPPGIL--- 475
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALggr 513

                          90
                  ....*....|..
gi 2470707909 476 MLNLKKIQFENN 487
Cdd:PLN03150  514 LLHRASFNFTDN 525
LRR_8 pfam13855
Leucine rich repeat;
388-444 6.87e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 6.87e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2470707909 388 LQVLILRNNPIKEI-PSAIEQLKYLRIFNIAFNFITTLPPG-FFSLSHLEKVDLSYNSI 444
Cdd:pfam13855   3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
364-514 6.68e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 6.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 364 QLVYIDLSFNHISSFPtEVFCVKYLQVLILRNNPIKEIPSaIEQLKYLRIFNIAFNFITTLPPGFFSLSHLEKVDLSYNS 443
Cdd:COG4886   229 NLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2470707909 444 IDFIPNEIQKLRSLTKLAINGNDLRSFPPGILMLNLKKIQFENNYTHPIFWKDVILNNPQKLTQLTAFLFL 514
Cdd:COG4886   307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 364-484 8.80e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 8.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 364 QLVYIDLSFNHIS-SFPTEVFCVKYLQVLILRNNPIK-EIPSAIEQLKY-LRIFNIAFN-FITTLPPGFfsLSHLEKVDL 439
Cdd:PLN00113   70 RVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSsLRYLNLSNNnFTGSIPRGS--IPNLETLDL 147

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2470707909 440 SYNSIDF-IPNEIQKLRSLTKLAINGNDLRSFPPGILMlNLKKIQF 484
Cdd:PLN00113  148 SNNMLSGeIPNDIGSFSSLKVLDLGGNVLVGKIPNSLT-NLTSLEF 192
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
352-533 5.15e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 5.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 352 ISNCPDLTPlafQLVYIDLSFNHISSFPteVFCVKYLQVLILrNNPIKEIPSAIEQLKYLRIFNIAFNFITTLPPGffsL 431
Cdd:PRK15387  234 LTSLPALPP---ELRTLEVSGNQLTSLP--VLPPGLLELSIF-SNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPG---L 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 432 SHLEKVDLSYNSIDFIPNEIQKLRSLTKLAINgndLRSFPPGILMLNLKKIQFENNYTHPI-FWKDVILNNpqKLTQLTA 510
Cdd:PRK15387  305 QELSVSDNQLASLPALPSELCKLWAYNNQLTS---LPTLPSGLQELSVSDNQLASLPTLPSeLYKLWAYNN--RLTSLPA 379

                         170       180
                  ....*....|....*....|....*....
gi 2470707909 511 F------LFLKRNLFKYYDVIPEEIQKLL 533
Cdd:PRK15387  380 LpsglkeLIVSGNRLTSLPVLPSELKELM 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 365-475 7.42e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 7.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 365 LVYIDLSFNHIS-SFPTEVFCVKYLQVL-ILRNNPIKEIPSAIEQLKYLRIFNIAFNFIT-TLPPGFFSLSHLEKVDLSY 441
Cdd:PLN00113  214 LKWIYLGYNNLSgEIPYEIGGLTSLNHLdLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSD 293

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2470707909 442 NSIDF-IPNEIQKLRSLTKLAINGNDLRSFPPGIL 475
Cdd:PLN00113  294 NSLSGeIPELVIQLQNLEILHLFSNNFTGKIPVAL 328
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 370-473 4.91e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 370 LSFN--HISSFPTEVFCvKYLQVLILRNNPIKEIP--SAIEQLKYLRIFNiafNFITTLPpGFFSLSHLEKVDLSYNSID 445
Cdd:cd21340     7 LYLNdkNITKIDNLSLC-KNLKVLYLYDNKITKIEnlEFLTNLTHLYLQN---NQIEKIE-NLENLVNLKKLYLGGNRIS 81

                          90       100
                  ....*....|....*....|....*...
gi 2470707909 446 FIPNeIQKLRSLTKLAINGNDLrsfPPG 473
Cdd:cd21340    82 VVEG-LENLTNLEELHIENQRL---PPG 105
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 411-465 5.18e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2470707909 411 LRIFNIAFNFITTLPPgFFSLSHLEKVDLSYNSI-DF--IPNEIQKLRSLTKLAINGN 465
Cdd:cd21340   122 LRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQIsDLeeLLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 323-472 5.75e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2470707909 323 DETVLSMINLAlltcqmyeRNAlslkgfFISNCPDLTPlAFQLVYIDLSFNHIS-SFPTEVFCVKYLQVLILRNNPIK-E 400
Cdd:PLN00113  450 DMPSLQMLSLA--------RNK------FFGGLPDSFG-SKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgE 514

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2470707909 401 IPSAIEQLKYLRIFNIAFNFIT-TLPPGFFSLSHLEKVDLSYNSIDF-IPNEIQKLRSLTKLAINGNDLR-SFPP 472
Cdd:PLN00113  515 IPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHgSLPS 589
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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