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Conserved domains on  [gi|2781606335|ref|XP_066804219|]
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hypothetical protein IAR55_002417 [Kwoniella newhampshirensis]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-601 1.96e-41

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.68  E-value: 1.96e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 138 AGHAKPITALSIRHQRPFRAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASVASDGKVFFYEGKTGE 217
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 218 VKGQVdREATSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIqsysvgsdissqqngivyanpdtlvsislsgtlnv 297
Cdd:COG2319   112 LLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL----------------------------------- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 298 fdtressstkwRTLQGPTKAITASAISPseDGKgaTFYAGSFDGTMKRFDIgegfgeKEGQCEDVKgTGHSARV--VGLS 375
Cdd:COG2319   156 -----------RTLTGHSGAVTSVAFSP--DGK--LLASGSDDGTVRLWDL------ATGKLLRTL-TGHTGAVrsVAFS 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 376 ADGKgKVWSAGWDDKVTAIEgesfassslptkaqpsgiaatsdavyVATTSGLEVLQSGSSSVivptptTAVAVHhgPNS 455
Cdd:COG2319   214 PDGK-LLASGSADGTVRLWD--------------------------LATGKLLRTLTGHSGSV------RSVAFS--PDG 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 456 DTLAYSSG-KVVTLASTSPQTTLATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEETAVSskWTFHTGRVVSL 534
Cdd:COG2319   259 RLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSV 336

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2781606335 535 AWAKSGKRLASGGLDENIYIWDTEKQlKNIPIRNAHPGGVSGVAWLEGNTKLVSTGADGIVRTWTIP 601
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-601 1.96e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.68  E-value: 1.96e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 138 AGHAKPITALSIRHQRPFRAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASVASDGKVFFYEGKTGE 217
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 218 VKGQVdREATSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIqsysvgsdissqqngivyanpdtlvsislsgtlnv 297
Cdd:COG2319   112 LLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL----------------------------------- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 298 fdtressstkwRTLQGPTKAITASAISPseDGKgaTFYAGSFDGTMKRFDIgegfgeKEGQCEDVKgTGHSARV--VGLS 375
Cdd:COG2319   156 -----------RTLTGHSGAVTSVAFSP--DGK--LLASGSDDGTVRLWDL------ATGKLLRTL-TGHTGAVrsVAFS 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 376 ADGKgKVWSAGWDDKVTAIEgesfassslptkaqpsgiaatsdavyVATTSGLEVLQSGSSSVivptptTAVAVHhgPNS 455
Cdd:COG2319   214 PDGK-LLASGSADGTVRLWD--------------------------LATGKLLRTLTGHSGSV------RSVAFS--PDG 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 456 DTLAYSSG-KVVTLASTSPQTTLATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEETAVSskWTFHTGRVVSL 534
Cdd:COG2319   259 RLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSV 336

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2781606335 535 AWAKSGKRLASGGLDENIYIWDTEKQlKNIPIRNAHPGGVSGVAWLEGNTKLVSTGADGIVRTWTIP 601
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-344 1.17e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 1.17e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335  45 LSHAYTQHTQTTTVARFSPSGFYAASADVAGNVRIWDVTQTENSLKLATRplSGKINDLAWDGESKRIIVGGEgkDKFGA 124
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGSS--DKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 125 AFFMDSGSSCGEIAGHAKPITALSIRHQRPFrAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASVAS 204
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 205 DGKVFFYEGKTGEVKGQVDREaTSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIQSYSVgsdissqQNGIVYA--- 281
Cdd:cd00200   156 DGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSvaf 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2781606335 282 --NPDTLVSISLSGTLNVFDTResSSTKWRTLQGPTKAITASAISPSedgkGATFYAGSFDGTMK 344
Cdd:cd00200   228 spDGYLLASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPD----GKRLASGSADGTIR 286
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 481-537 3.74e-08

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 51.12  E-value: 3.74e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2781606335 481 EDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEETAvsSKWTFHTGRVVSLAWA 537
Cdd:pfam12894  35 DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV--HHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 522-556 1.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2781606335  522 SKWTFHTGRVVSLAWAKSGKRLASGGLDENIYIWD 556
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 174-348 9.44e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 9.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 174 FKYDKMINThTRFVRDVAFSPNGDLFASVASDGKVFFYEGKTGEVKGQ------VDREATSSLMACSW-APDSSKIATAG 246
Cdd:PLN00181  474 LKQGDLLNS-SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvVELASRSKLSGICWnSYIKSQVASSN 552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 247 ADGVVSIWD------ASSFKSIQSYSVGSDISSqqngivyANPDTLVSISLSGTLNVFDTRESSSTKwrTLQgpTKAITA 320
Cdd:PLN00181  553 FEGVVQVWDvarsqlVTEMKEHEKRVWSIDYSS-------ADPTLLASGSDDGSVKLWSINQGVSIG--TIK--TKANIC 621

                         170       180
                  ....*....|....*....|....*...
gi 2781606335 321 SAISPSEDGKGATFyaGSFDGTMKRFDI 348
Cdd:PLN00181  622 CVQFPSESGRSLAF--GSADHKVYYYDL 647
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-601 1.96e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.68  E-value: 1.96e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 138 AGHAKPITALSIRHQRPFRAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASVASDGKVFFYEGKTGE 217
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 218 VKGQVdREATSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIqsysvgsdissqqngivyanpdtlvsislsgtlnv 297
Cdd:COG2319   112 LLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL----------------------------------- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 298 fdtressstkwRTLQGPTKAITASAISPseDGKgaTFYAGSFDGTMKRFDIgegfgeKEGQCEDVKgTGHSARV--VGLS 375
Cdd:COG2319   156 -----------RTLTGHSGAVTSVAFSP--DGK--LLASGSDDGTVRLWDL------ATGKLLRTL-TGHTGAVrsVAFS 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 376 ADGKgKVWSAGWDDKVTAIEgesfassslptkaqpsgiaatsdavyVATTSGLEVLQSGSSSVivptptTAVAVHhgPNS 455
Cdd:COG2319   214 PDGK-LLASGSADGTVRLWD--------------------------LATGKLLRTLTGHSGSV------RSVAFS--PDG 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 456 DTLAYSSG-KVVTLASTSPQTTLATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEETAVSskWTFHTGRVVSL 534
Cdd:COG2319   259 RLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--LTGHTGAVRSV 336

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2781606335 535 AWAKSGKRLASGGLDENIYIWDTEKQlKNIPIRNAHPGGVSGVAWLEGNTKLVSTGADGIVRTWTIP 601
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-344 1.17e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 1.17e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335  45 LSHAYTQHTQTTTVARFSPSGFYAASADVAGNVRIWDVTQTENSLKLATRplSGKINDLAWDGESKRIIVGGEgkDKFGA 124
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGH--TGPVRDVAASADGTYLASGSS--DKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 125 AFFMDSGSSCGEIAGHAKPITALSIRHQRPFrAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASVAS 204
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 205 DGKVFFYEGKTGEVKGQVDREaTSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIQSYSVgsdissqQNGIVYA--- 281
Cdd:cd00200   156 DGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSvaf 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2781606335 282 --NPDTLVSISLSGTLNVFDTResSSTKWRTLQGPTKAITASAISPSedgkGATFYAGSFDGTMK 344
Cdd:cd00200   228 spDGYLLASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPD----GKRLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
44-391 7.88e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 7.88e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335  44 GLSHAYTQHTQTTTVARFSPSGFYAASADVAGNVRIWDVTQTEnsLKLATRPLSGKINDLAWDGESKRIIVGGEGKdkfG 123
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPDGKTLASGSADG---T 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 124 AAFF-MDSGSSCGEIAGHAKPITALSIRHQRPfRAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASV 202
Cdd:COG2319   144 VRLWdLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 203 ASDGKVFFYEGKTGEVkGQVDREATSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIQSYSVGSDISsqqNGIVYAn 282
Cdd:COG2319   223 SADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV---NSVAFS- 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 283 PD--TLVSISLSGTLNVFDTreSSSTKWRTLQGPTKAITASAISPseDGKgaTFYAGSFDGTMKRFDIgegfgekEGQCE 360
Cdd:COG2319   298 PDgkLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSP--DGK--TLASGSDDGTVRLWDL-------ATGEL 364

                         330       340       350
                  ....*....|....*....|....*....|...
gi 2781606335 361 DVKGTGHSARV--VGLSADGKgKVWSAGWDDKV 391
Cdd:COG2319   365 LRTLTGHTGAVtsVAFSPDGR-TLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
191-598 1.25e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 191 AFSPNGDLFASVASDGKVFFYEGKTGEVkGQVDREATSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIQSYSVGSD 270
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGAL-LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 271 isSQQNGIVYANPDTLVSISLSGTLNVFDTreSSSTKWRTLQGPTKAITASAISPseDGKgaTFYAGSFDGTMKRFDIge 350
Cdd:COG2319    80 --AVLSVAFSPDGRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSP--DGK--TLASGSADGTVRLWDL-- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 351 gfgeKEGQCEDVKgTGHSARVVGL--SADGKgKVWSAGWDDKVTAIEgesfassslptkaqpsgiaatsdavyVATTSGL 428
Cdd:COG2319   150 ----ATGKLLRTL-TGHSGAVTSVafSPDGK-LLASGSDDGTVRLWD--------------------------LATGKLL 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 429 EVLQSGSSSVivptptTAVAVHhgPNSDTLAYSSG-KVVTLASTSPQTTLATFEDNRGEVLSLAFSPDGRYLAAGDATGR 507
Cdd:COG2319   198 RTLTGHTGAV------RSVAFS--PDGKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 508 IILIDVEKEETAVSskWTFHTGRVVSLAWAKSGKRLASGGLDENIYIWDTEKQlKNIPIRNAHPGGVSGVAWLEGNTKLV 587
Cdd:COG2319   270 VRLWDLATGELLRT--LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLA 346

                         410
                  ....*....|.
gi 2781606335 588 STGADGIVRTW 598
Cdd:COG2319   347 SGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
47-348 7.97e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 7.97e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335  47 HAYTQHTQTTTVARFSPSGFYAASADVAGNVRIWDVTQTEnslKLAT-RPLSGKINDLAWDGESKRIIVGGEgkDKFGAA 125
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK---LLRTlTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 126 FFMDSGSSCGEIAGHAKPITALSIRHQRPfRAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASVASD 205
Cdd:COG2319   189 WDLATGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 206 GKVFFYEGKTGEVKGQVDREaTSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIQSYSVGSDissQQNGIVYAnPD- 284
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG---AVRSVAFS-PDg 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2781606335 285 -TLVSISLSGTLNVFDTreSSSTKWRTLQGPTKAITASAISPseDGKgaTFYAGSFDGTMKRFDI 348
Cdd:COG2319   343 kTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSP--DGR--TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-556 1.73e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 1.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 227 TSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIQSYSVGSDisSQQNGIVYANPDTLVSISLSGTLNVFDTRESSST 306
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 307 kwRTLQGPTKAITASAISPSEDgkgaTFYAGSFDGTMKRFDIgegfgeKEGQCEDVkGTGHSARVVGLSADGKGKVWSAG 386
Cdd:cd00200    87 --RTLTGHTSYVSSVAFSPDGR----ILSSSSRDKTIKVWDV------ETGKCLTT-LRGHTDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 387 WDDKvtaiegesfassslptkaqpsgiaatsdAVYV---ATTSGLEVLQSGSSSVivptptTAVAVHhgPNSDTLAYSSG 463
Cdd:cd00200   154 SQDG----------------------------TIKLwdlRTGKCVATLTGHTGEV------NSVAFS--PDGEKLLSSSS 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 464 -KVVTLASTSPQTTLATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEETavSSKWTFHTGRVVSLAWAKSGKR 542
Cdd:cd00200   198 dGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC--VQTLSGHTNSVTSLAWSPDGKR 275

                         330
                  ....*....|....
gi 2781606335 543 LASGGLDENIYIWD 556
Cdd:cd00200   276 LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-255 7.29e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 7.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335  45 LSHAYTQHTQTTTVARFSPSGFYAASADVAGNVRIWDVTQTEnsLKLATRPLSGKINDLAWDGeSKRIIVGGeGKDKFGA 124
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSP-DGTFVASS-SQDGTIK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 125 AFFMDSGSSCGEIAGHAKPITALSIrHQRPFRAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASVAS 204
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2781606335 205 DGKVFFYEGKTGEVKGQVdREATSSLMACSWAPDSSKIATAGADGVVSIWD 255
Cdd:cd00200   240 DGTIRVWDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
45-258 1.03e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335  45 LSHAYTQHTQTTTVARFSPSGFYAASADVAGNVRIWDVTQTENSLKLATRplSGKINDLAWDGESKRIIVGGEGkdkfGA 124
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH--SGSVRSVAFSPDGRLLASGSAD----GT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 125 AFF--MDSGSSCGEIAGHAKPITALSIRHQRPfRAISGSDDNSVIFHTAVPFKYDKMINTHTRFVRDVAFSPNGDLFASV 202
Cdd:COG2319   270 VRLwdLATGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2781606335 203 ASDGKVFFYEGKTGEVKgQVDREATSSLMACSWAPDSSKIATAGADGVVSIWDASS 258
Cdd:COG2319   349 SDDGTVRLWDLATGELL-RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 449-600 3.27e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 3.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 449 VHHGPNSDTLAYSSGKvvTLASTSPQTTL-----------ATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEE 517
Cdd:cd00200    49 GHTGPVRDVAASADGT--YLASGSSDKTIrlwdletgecvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 518 TAVSskWTFHTGRVVSLAWAKSGKRLASGGLDENIYIWD--TEKQLKNIPirnAHPGGVSGVAWLEGNTKLVSTGADGIV 595
Cdd:cd00200   127 CLTT--LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDlrTGKCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTI 201


                  ....*
gi 2781606335 596 RTWTI 600
Cdd:cd00200   202 KLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 477-601 2.86e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 2.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 477 LATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEEtaVSSKWTFHTGRVVSLAWAKSGKRLASGGLDENIYIWD 556
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2781606335 557 TEKQLKNIPIRnAHPGGVSGVAWLEGNTKLVSTGADGIVRTWTIP 601
Cdd:cd00200    80 LETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 481-537 3.74e-08

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 51.12  E-value: 3.74e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2781606335 481 EDNRGEVLSLAFSPDGRYLAAGDATGRIILIDVEKEETAvsSKWTFHTGRVVSLAWA 537
Cdd:pfam12894  35 DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV--HHFSAGSDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 453-560 2.65e-07

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 53.89  E-value: 2.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335  453 PNSDTLAYSS---GK----VVTLASTSPQTTLATFEDnrGEVLSLAFSPDGRYLAAGDATGRIILIDVE--KEETAVSSK 523
Cdd:COG4946    352 PDGKSIAYFSdasGEyelyIAPADGSGEPKQLTLGDL--GRVFNPVWSPDGKKIAFTDNRGRLWVVDLAsgKVRKVDTDG 429

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2781606335  524 WTFHTGRVV-S-----LAWAKSGKRLASggldeNIYIWDTEKQ 560
Cdd:COG4946    430 YGDGISDLAwSpdskwLAYSKPGPNQLS-----QIFLYDVETG 467
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 522-556 1.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2781606335  522 SKWTFHTGRVVSLAWAKSGKRLASGGLDENIYIWD 556
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 174-348 9.44e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 9.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 174 FKYDKMINThTRFVRDVAFSPNGDLFASVASDGKVFFYEGKTGEVKGQ------VDREATSSLMACSW-APDSSKIATAG 246
Cdd:PLN00181  474 LKQGDLLNS-SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRdihypvVELASRSKLSGICWnSYIKSQVASSN 552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 247 ADGVVSIWD------ASSFKSIQSYSVGSDISSqqngivyANPDTLVSISLSGTLNVFDTRESSSTKwrTLQgpTKAITA 320
Cdd:PLN00181  553 FEGVVQVWDvarsqlVTEMKEHEKRVWSIDYSS-------ADPTLLASGSDDGSVKLWSINQGVSIG--TIK--TKANIC 621

                         170       180
                  ....*....|....*....|....*...
gi 2781606335 321 SAISPSEDGKGATFyaGSFDGTMKRFDI 348
Cdd:PLN00181  622 CVQFPSESGRSLAF--GSADHKVYYYDL 647
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
158-300 9.95e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 9.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 158 ISGSDDNSVIFHTAVPFKYDKMINTHTRfVRDVAFSPNGD-LFASVASDGKVFFYEGKTGEVKGQVDREATSSLMACSwa 236
Cdd:COG3391    84 VANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVD-- 160

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2781606335 237 PDSSKIATAGADG-----VVSIWDASSFKSIQSYSVGSD-----ISSQQNGIVYANPDTLVSISLSGTLNVFDT 300
Cdd:COG3391   161 PDGKRLYVANSGSntvsvIVSVIDTATGKVVATIPVGGGpvgvaVSPDGRRLYVANRGSNTSNGGSNTVSVIDL 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-212 1.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2781606335  173 PFKYDKMINTHTRFVRDVAFSPNGDLFASVASDGKVFFYE 212
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
527-556 2.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 2.27e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 2781606335 527 HTGRVVSLAWAKSGKRLASGGLDENIYIWD 556
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 477-512 5.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.37e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2781606335  477 LATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILID 512
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-255 9.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 9.14e-04
                           10        20
                   ....*....|....*....|....*....
gi 2781606335  227 TSSLMACSWAPDSSKIATAGADGVVSIWD 255
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
188-453 2.80e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.00  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 188 RDVAFSPNGDLFASVASDGKVFFYEGKTGEVKgQVDREATSSLMACSWAPDSSK-IATAGADGVVSIwDASSfKSIQSYS 266
Cdd:COG4257    20 RDVAVDPDGAVWFTDQGGGRIGRLDPATGEFT-EYPLGGGSGPHGIAVDPDGNLwFTDNGNNRIGRI-DPKT-GEITTFA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 267 VGSDIsSQQNGIVYANPDTL-VSISLSGTLNVFDTresSSTKWRTLQGPTKAITASAISPseDGKGATFYAGSFDGTMKR 345
Cdd:COG4257    97 LPGGG-SNPHGIAFDPDGNLwFTDQGGNRIGRLDP---ATGEVTEFPLPTGGAGPYGIAV--DPDGNLWVTDFGANAIGR 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 346 FDIgegfgeKEGQCEDVKGTGHSARVVGLSADGKGKVWSAGWD-DKVTAI--EGESFASSSLPTK-AQPSGIAATSD-AV 420
Cdd:COG4257   171 IDP------DTGTLTEYALPTPGAGPRGLAVDPDGNLWVADTGsGRIGRFdpKTGTVTEYPLPGGgARPYGVAVDGDgRV 244

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2781606335 421 YVAttsglevlQSGSSSVIVPTPTTAVAVHHGP 453
Cdd:COG4257   245 WFA--------ESGANRIVRFDPDTELTEYVLP 269
WD40 pfam00400
WD domain, G-beta repeat;
475-512 3.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2781606335 475 TTLATFEDNRGEVLSLAFSPDGRYLAAGDATGRIILID 512
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
178-212 3.94e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2781606335 178 KMINTHTRFVRDVAFSPNGDLFASVASDGKVFFYE 212
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
RAB3GAP2_N pfam14655
Rab3 GTPase-activating protein regulatory subunit N-terminus; This family includes the ...
 482-513 5.58e-03

Rab3 GTPase-activating protein regulatory subunit N-terminus; This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily.


Pssm-ID: 464240  Cd Length: 416  Bit Score: 39.60  E-value: 5.58e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2781606335 482 DNRGEVLSLAFSPDGRYLAAGDATGRIILIDV 513
Cdd:pfam14655 307 DSKREGESITLSPSGRLAAVTDSLGRVLLLDV 338
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 190-270 5.82e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 5.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606335 190 VAFSPNGDLFASVASDGKVFFYEGKTGEVKGQVDREATSSLMACSWAPDSSKIATAGADGVVSIWDASSFKSIQSYSVGS 269
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80


                  .
gi 2781606335 270 D 270
Cdd:pfam12894  81 D 81
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 489-559 8.17e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.75  E-value: 8.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2781606335 489 SLAFSPDGRYLAAGDATGRIILIDVEKEETAVSSKwTFHTGRVVSLAWAKSGKRLASGGLDENIYIWDTEK 559
Cdd:cd22857   228 AVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFK-GKCGGSIRSIARHPELPLIASCGLDRYLRIWDTET 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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