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Conserved domains on  [gi|2781606347|ref|XP_066804221|]
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hypothetical protein IAR55_002419 [Kwoniella newhampshirensis]

Protein Classification

N5-glutamine methyltransferase family protein( domain architecture ID 11458394)

N5-glutamine methyltransferase family protein such as peptide chain release factor N(5)-glutamine methyltransferase, which modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12826405|12504684|12741815
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 69-366 7.32e-61

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 197.29  E-value: 7.32e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  69 DATNELRWIVSEV----RSHAAKEMARgRLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSETAH 144
Cdd:COG2890    21 SARLEAELLLAHVlgldRADLLLHPDR-PLTEEELARLEALVARRAAGEPLAYILGEAEFYGLEFKVDPGVLIPRPETEE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 145 IftllsqsilssISLLSSAARPKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSERVKVR 224
Cdd:COG2890   100 L-----------VELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 225 YGNVFSDpealllgaqLREGGRIGMVVSNPPYIPYDQYQDLPRSVRVYESPSALLGDglrhyepGRGLKFYERISQVLED 304
Cdd:COG2890   169 QGDLFEP---------LPGDGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALDGG-------EDGLDFYRRIIAQAPR 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2781606347 305 LLVEeekmvnQGWsdiprVAVEVGLGQATEVEDILRSSKGGVVgrtEVWKDQYGSDRMVVGW 366
Cdd:COG2890   233 LLKP------GGW-----LLLEIGEDQGEAVRALLEAAGFADV---ETHKDLAGRDRVVVAR 280
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 69-366 7.32e-61

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 197.29  E-value: 7.32e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  69 DATNELRWIVSEV----RSHAAKEMARgRLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSETAH 144
Cdd:COG2890    21 SARLEAELLLAHVlgldRADLLLHPDR-PLTEEELARLEALVARRAAGEPLAYILGEAEFYGLEFKVDPGVLIPRPETEE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 145 IftllsqsilssISLLSSAARPKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSERVKVR 224
Cdd:COG2890   100 L-----------VELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 225 YGNVFSDpealllgaqLREGGRIGMVVSNPPYIPYDQYQDLPRSVRVYESPSALLGDglrhyepGRGLKFYERISQVLED 304
Cdd:COG2890   169 QGDLFEP---------LPGDGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALDGG-------EDGLDFYRRIIAQAPR 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2781606347 305 LLVEeekmvnQGWsdiprVAVEVGLGQATEVEDILRSSKGGVVgrtEVWKDQYGSDRMVVGW 366
Cdd:COG2890   233 LLKP------GGW-----LLLEIGEDQGEAVRALLEAAGFADV---ETHKDLAGRDRVVVAR 280
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 68-365 6.80e-52

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 173.81  E-value: 6.80e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  68 NDATNELRWIVSEV----RS--HAAKEMArgrLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSE 141
Cdd:PRK09328   16 ASPRLDAELLLAHVlglsRTdlLLNPEEE---LTPEELERFRALVARRAAGEPLQYILGEAEFWGLDFKVSPGVLIPRPE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 142 TAHIFtllsqsilssiSLLSSAARPKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQmSERV 221
Cdd:PRK09328   93 TEELV-----------EWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL-GARV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 222 KVRYGNVFsdpEALllgaqlrEGGRIGMVVSNPPYIPYDQYQDLPRSVRVYESPSALLGDglrhyepGRGLKFYERISQV 301
Cdd:PRK09328  161 EFLQGDWF---EPL-------PGGRFDLIVSNPPYIPEADIHLLQPEVRDHEPHLALFGG-------EDGLDFYRRIIEQ 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2781606347 302 LEDLLVEeekmvnQGWsdiprVAVEVGLGQATEVEDILRSSKGGVVgrtEVWKDQYGSDRMVVG 365
Cdd:PRK09328  224 APRYLKP------GGW-----LLLEIGYDQGEAVRALLAAAGFADV---ETRKDLAGRDRVVLG 273
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 94-364 1.98e-49

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 166.49  E-value: 1.98e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  94 LPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSETAHIftllsqsilssisLLSSAARPKEPLSIL 173
Cdd:TIGR03534  25 LTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEEL-------------VEAALERLKKGPRVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 174 DLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMsERVKVRYGNVFsdpEALLlgaqlreGGRIGMVVSN 253
Cdd:TIGR03534  92 DLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGL-ENVEFLQGDWF---EPLP-------SGKFDLIVSN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 254 PPYIPYDQYQDLPRSVRVYESPSALLGdglrhyePGRGLKFYERISQVLEDLLVEEekmvnqGWsdiprVAVEVGLGQAT 333
Cdd:TIGR03534 161 PPYIPEADIHLLDPEVRDFEPRLALFG-------GEDGLDFYRRIIAQAPRLLKPG------GW-----LLLEIGYDQGE 222

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2781606347 334 EVEDILRSSKGGVVgrtEVWKDQYGSDRMVV 364
Cdd:TIGR03534 223 AVRALFEAAGFADV---ETRKDLAGKDRVVL 250
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 172-255 2.29e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 44.50  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 172 ILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMsERVKVRYGNVFSDPEAlllgaqlregGRIGMVV 251
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVED----------GKFDLII 103


                  ....
gi 2781606347 252 SNPP 255
Cdd:pfam05175 104 SNPP 107
 
Name Accession Description Interval E-value
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 69-366 7.32e-61

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 197.29  E-value: 7.32e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  69 DATNELRWIVSEV----RSHAAKEMARgRLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSETAH 144
Cdd:COG2890    21 SARLEAELLLAHVlgldRADLLLHPDR-PLTEEELARLEALVARRAAGEPLAYILGEAEFYGLEFKVDPGVLIPRPETEE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 145 IftllsqsilssISLLSSAARPKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSERVKVR 224
Cdd:COG2890   100 L-----------VELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 225 YGNVFSDpealllgaqLREGGRIGMVVSNPPYIPYDQYQDLPRSVRVYESPSALLGDglrhyepGRGLKFYERISQVLED 304
Cdd:COG2890   169 QGDLFEP---------LPGDGRFDLIVSNPPYIPEDEIALLPPEVRDHEPRLALDGG-------EDGLDFYRRIIAQAPR 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2781606347 305 LLVEeekmvnQGWsdiprVAVEVGLGQATEVEDILRSSKGGVVgrtEVWKDQYGSDRMVVGW 366
Cdd:COG2890   233 LLKP------GGW-----LLLEIGEDQGEAVRALLEAAGFADV---ETHKDLAGRDRVVVAR 280
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 68-365 6.80e-52

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 173.81  E-value: 6.80e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  68 NDATNELRWIVSEV----RS--HAAKEMArgrLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSE 141
Cdd:PRK09328   16 ASPRLDAELLLAHVlglsRTdlLLNPEEE---LTPEELERFRALVARRAAGEPLQYILGEAEFWGLDFKVSPGVLIPRPE 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 142 TAHIFtllsqsilssiSLLSSAARPKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQmSERV 221
Cdd:PRK09328   93 TEELV-----------EWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGL-GARV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 222 KVRYGNVFsdpEALllgaqlrEGGRIGMVVSNPPYIPYDQYQDLPRSVRVYESPSALLGDglrhyepGRGLKFYERISQV 301
Cdd:PRK09328  161 EFLQGDWF---EPL-------PGGRFDLIVSNPPYIPEADIHLLQPEVRDHEPHLALFGG-------EDGLDFYRRIIEQ 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2781606347 302 LEDLLVEeekmvnQGWsdiprVAVEVGLGQATEVEDILRSSKGGVVgrtEVWKDQYGSDRMVVG 365
Cdd:PRK09328  224 APRYLKP------GGW-----LLLEIGYDQGEAVRALLAAAGFADV---ETRKDLAGRDRVVLG 273
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 94-364 1.98e-49

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 166.49  E-value: 1.98e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  94 LPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSETAHIftllsqsilssisLLSSAARPKEPLSIL 173
Cdd:TIGR03534  25 LTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEEL-------------VEAALERLKKGPRVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 174 DLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMsERVKVRYGNVFsdpEALLlgaqlreGGRIGMVVSN 253
Cdd:TIGR03534  92 DLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGL-ENVEFLQGDWF---EPLP-------SGKFDLIVSN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 254 PPYIPYDQYQDLPRSVRVYESPSALLGdglrhyePGRGLKFYERISQVLEDLLVEEekmvnqGWsdiprVAVEVGLGQAT 333
Cdd:TIGR03534 161 PPYIPEADIHLLDPEVRDFEPRLALFG-------GEDGLDFYRRIIAQAPRLLKPG------GW-----LLLEIGYDQGE 222

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2781606347 334 EVEDILRSSKGGVVgrtEVWKDQYGSDRMVV 364
Cdd:TIGR03534 223 AVRALFEAAGFADV---ETRKDLAGKDRVVL 250
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 88-365 1.13e-41

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 147.50  E-value: 1.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  88 EMARGRLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSETAHIftllsqsilssISLLSSAARPK 167
Cdd:TIGR00536  44 AFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFYGLEFFVNEHVLIPRPETEEL-----------VEKALASLISQ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 168 EP-LSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSERVKVRYGNVFSDpealLLGAQlreggr 246
Cdd:TIGR00536 113 PPiLHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNLFEP----LAGQK------ 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 247 IGMVVSNPPYIPYDQYQDLPRSVRvYESPSALLGDglrhyepGRGLKFYERISQVLEDLLVEEEKMVnqgwsdiprvaVE 326
Cdd:TIGR00536 183 IDIIVSNPPYIDEEDLADLPNVVR-FEPLLALVGG-------DDGLNILRQIIELAPDYLKPNGFLV-----------CE 243

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2781606347 327 VGLGQATEVEDILRSSKGGVvgRTEVWKDQYGSDRMVVG 365
Cdd:TIGR00536 244 IGNWQQKSLKELLRIKFTWY--DVENGRDLNGKERVVLG 280
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 87-283 1.41e-22

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 96.04  E-value: 1.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  87 KEMARGRLPPIEDERVGQLVRRRAEGE-PLQYILGSTDFGPLNLLCKKPVLIPRSETAHIFTLLSQSILSsisllssaar 165
Cdd:TIGR03533  49 EPFLDARLTPSEKERILELIERRIEERiPVAYLTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLE---------- 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 166 PKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSERVKVRYGNVFSdpeALllgaqlrEGG 245
Cdd:TIGR03533 119 PEPVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQSDLFA---AL-------PGR 188

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2781606347 246 RIGMVVSNPPYIPYDQYQDLPRSVRvYESPSALLG--DGL 283
Cdd:TIGR03533 189 KYDLIVSNPPYVDAEDMADLPAEYH-HEPELALASgeDGL 227
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 93-286 8.80e-15

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 75.29  E-value: 8.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  93 RLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSETA-------HIFTLLSQSILSSISLLSSAAR 165
Cdd:PRK01544   50 QLNEAEIEAFEKLLERRLKHEPIAYITGVKEFYSREFIVNKHVLIPRSDTEvlvdvvfQCHSRESGNPEKKQLNPCFRGN 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 166 PKEP------LSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSERVKVRYGNVFSDpeallLGA 239
Cdd:PRK01544  130 DISSncndkfLNILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNAIKYEVTDRIQIIHSNWFEN-----IEK 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2781606347 240 QlreggRIGMVVSNPPYIPYDQYQDLPRSVRVYESPSALLG--DGLRHY 286
Cdd:PRK01544  205 Q-----KFDFIVSNPPYISHSEKSEMAIETINYEPSIALFAeeDGLQAY 248
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 163-256 1.72e-12

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 66.32  E-value: 1.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 163 AARPKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSERVKVRYGNVFSDPEALllgaqlr 242
Cdd:COG4123    32 FAPVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAAEL------- 104

                          90
                  ....*....|....
gi 2781606347 243 EGGRIGMVVSNPPY 256
Cdd:COG4123   105 PPGSFDLVVSNPPY 118
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 64-257 1.00e-09

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 59.71  E-value: 1.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347  64 ELSENDATNELRWIVSEVRshaAKEMARG--RLPPIEDERVGQLVRRRAEGEPLQYILGSTDFGPLNLLCKKPVLIPRSE 141
Cdd:PRK14966  161 KLPKNEARMLLQYASEYTR---VQLLTRGgeEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYGRRFAVNPNVLIPRPE 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 142 TAHIFTLLSqsilssisllssaARPKEPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLqmSERV 221
Cdd:PRK14966  238 TEHLVEAVL-------------ARLPENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADL--GARV 302

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2781606347 222 KVRYGNVFSdpealllgAQLREGGRIGMVVSNPPYI 257
Cdd:PRK14966  303 EFAHGSWFD--------TDMPSEGKWDIIVSNPPYI 330
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 172-256 8.11e-07

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 49.03  E-value: 8.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 172 ILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMsERVKVRYGNVFSDPEalllgaqlreGGRIGMVV 251
Cdd:COG2813    53 VLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGL-ENVEVLWSDGLSGVP----------DGSFDLIL 121


                  ....*
gi 2781606347 252 SNPPY 256
Cdd:COG2813   122 SNPPF 126
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 172-255 2.29e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 44.50  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 172 ILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMsERVKVRYGNVFSDPEAlllgaqlregGRIGMVV 251
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVED----------GKFDLII 103


                  ....
gi 2781606347 252 SNPP 255
Cdd:pfam05175 104 SNPP 107
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
168-247 2.56e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 42.50  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 168 EPLSILDLCTGSACIPLLMTHLNPLCTVVGIDNSPAAVALGNANVQKLQMSE------RVKVRYGNVFS--------DPE 233
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVadlrdlDPPEPFDLVVSnaalhwlpDHA 80

                          90
                  ....*....|....*.
gi 2781606347 234 ALL--LGAQLREGGRI 247
Cdd:COG4106    81 ALLarLAAALAPGGVL 96
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 94-120 2.82e-05

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 41.70  E-value: 2.82e-05
                          10        20
                  ....*....|....*....|....*..
gi 2781606347  94 LPPIEDERVGQLVRRRAEGEPLQYILG 120
Cdd:pfam17827  45 LSEEELERFEELLERRAAGEPLQYILG 71
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 166-235 7.98e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 39.32  E-value: 7.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2781606347 166 PKEPLSILDLCTGSACIPLLMTH-LNPLCTVVGIDNSPAAVALGNANVQKLQmSERVKVRYGNVFSDPEAL 235
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARENAQKLG-FDNVEFEQGDIEELPELL 70
PRK14967 PRK14967
putative methyltransferase; Provisional
 172-258 1.65e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.27  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 172 ILDLCTGSACIPLLMTHLNPlCTVVGIDNSPAAVALGNANVqkLQMSERVKVRYGNvfsdpeallLGAQLReGGRIGMVV 251
Cdd:PRK14967   40 VLDLCTGSGALAVAAAAAGA-GSVTAVDISRRAVRSARLNA--LLAGVDVDVRRGD---------WARAVE-FRPFDVVV 106


                  ....*..
gi 2781606347 252 SNPPYIP 258
Cdd:PRK14967  107 SNPPYVP 113
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 163-255 2.21e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 38.05  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2781606347 163 AARPKEPLSILDLCTGSACIPLLMTHLNplCTVVGIDNSPAAVALGNANVQKLQMseRVKVRYGNV-------------- 228
Cdd:COG2226    17 ALGLRPGARVLDLGCGTGRLALALAERG--ARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAedlpfpdgsfdlvi 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2781606347 229 -------FSDPEALLLGAQ--LREGGRIGMVVSNPP 255
Cdd:COG2226    93 ssfvlhhLPDPERALAEIArvLKPGGRLVVVDFSPP 128
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 164-215 3.44e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 38.36  E-value: 3.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2781606347 164 ARPKEPLSILDLCTGSAcipllmTHLNPLC-----TVVGIDNSPAAVALGNANVQKL 215
Cdd:COG0500    22 ERLPKGGRVLDLGCGTG------RNLLALAarfggRVIGIDLSPEAIALARARAAKA 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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