NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|347971211|ref|XP_309639|]
View 

AGAP004088-PA [Anopheles gambiae str. PEST]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 13791650)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
805-1106 6.32e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.78  E-value: 6.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  805 NSALDNAVEDERFELARFLVERLHFDATDVFNELRQQYEQNPQFNDYKRLHSLCRDGEFAMVRQMIEEKCLDAQQEYDGS 884
Cdd:COG0666     9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  885 NIFIQAASSGNLELVQYLCEtHGflARIDDRDEHGFTAMRQAMVQGHQPIVLYLRKHNATVNpswmqqssnvsAVDDSei 964
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLE-AG--ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN-----------AQDND-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  965 dtedflaliacdrerlarlsidynryesGELLLHCYIRYvdePDEDTFRFLLAQYDNVDIRTDAscelrcGETPLHLAYQ 1044
Cdd:COG0666   153 ----------------------------GNTPLHLAAAN---GNLEIVKLLLEAGADVNARDND------GETPLHLAAE 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347971211 1045 SGNKRCREILLESGADIYAKSlRHGLTTLHFAIMgsAEREIIEQLLDVYGFDVNTRDERGRT 1106
Cdd:COG0666   196 NGHLEIVKLLLEAGADVNAKD-NDGKTALDLAAE--NGNLEIVKLLLEAGADLNAKDKDGLT 254
Ank_5 pfam13857
Ankyrin repeats (many copies);
1158-1214 2.90e-08

Ankyrin repeats (many copies);


:

Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.19  E-value: 2.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 347971211  1158 LLQTLQVPQSHTDARGRLPLHYAVEADNCPIVRLLLKYRQDlCNVPDSEGLTAVQVA 1214
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVD-LNLKDEEGLTALDLA 56
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
654-727 5.35e-03

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  654 ITDCLQRNLLH--VVHGSKEIADLLLSAEVPLEQQcvgQLNHWTPILVAIERKDWPLVDRLLAKGAKLST----GQTKLH 727
Cdd:COG0666   148 AQDNDGNTPLHlaAANGNLEIVKLLLEAGADVNAR---DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdndGKTALD 224
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
805-1106 6.32e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.78  E-value: 6.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  805 NSALDNAVEDERFELARFLVERLHFDATDVFNELRQQYEQNPQFNDYKRLHSLCRDGEFAMVRQMIEEKCLDAQQEYDGS 884
Cdd:COG0666     9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  885 NIFIQAASSGNLELVQYLCEtHGflARIDDRDEHGFTAMRQAMVQGHQPIVLYLRKHNATVNpswmqqssnvsAVDDSei 964
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLE-AG--ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN-----------AQDND-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  965 dtedflaliacdrerlarlsidynryesGELLLHCYIRYvdePDEDTFRFLLAQYDNVDIRTDAscelrcGETPLHLAYQ 1044
Cdd:COG0666   153 ----------------------------GNTPLHLAAAN---GNLEIVKLLLEAGADVNARDND------GETPLHLAAE 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347971211 1045 SGNKRCREILLESGADIYAKSlRHGLTTLHFAIMgsAEREIIEQLLDVYGFDVNTRDERGRT 1106
Cdd:COG0666   196 NGHLEIVKLLLEAGADVNAKD-NDGKTALDLAAE--NGNLEIVKLLLEAGADLNAKDKDGLT 254
PHA03095 PHA03095
ankyrin-like protein; Provisional
 991-1214 1.30e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.31  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  991 ESGELLLHCYIRYVDEPDEDTFRFLLAQYDNVDIRTdascelRCGETPLHLAYQSGNK-RCREILLESGADIYAKSlRHG 1069
Cdd:PHA03095   45 EYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAPE------RCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKD-KVG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1070 LTTLHFAIMG-SAEREIIEQLLDvYGFDVNTRDERGRTiSFYMPVKS-----ELYRWLVERyQFDPCAADNNGQTVLHHr 1143
Cdd:PHA03095  118 RTPLHVYLSGfNINPKVIRLLLR-KGADVNALDLYGMT-PLAVLLKSrnanvELLRLLIDA-GADVYAVDDRFRSLLHH- 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347971211 1144 vIKNSFFARAEIEFLLQTLQVPQSHTDARGRLPLHYAVEADNCP---IVRLLLKYRQDlcNVPDSEGLTAVQVA 1214
Cdd:PHA03095  194 -HLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrslVLPLLIAGISI--NARNRYGQTPLHYA 264
Ank_2 pfam12796
Ankyrin repeats (3 copies);
854-946 1.99e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 1.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211   854 LHSLCRDGEFAMVRQMIEEKCLDAQQEYDGSNIFIQAASSGNLELVQYLCEThgflARIDDRDeHGFTAMRQAMVQGHQP 933
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH----ADVNLKD-NGRTALHYAARSGHLE 75

                           90
                   ....*....|...
gi 347971211   934 IVLYLRKHNATVN 946
Cdd:pfam12796   76 IVKLLLEKGADIN 88
Ank_5 pfam13857
Ankyrin repeats (many copies);
1158-1214 2.90e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.19  E-value: 2.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 347971211  1158 LLQTLQVPQSHTDARGRLPLHYAVEADNCPIVRLLLKYRQDlCNVPDSEGLTAVQVA 1214
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVD-LNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1035-1063 3.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.78e-03
                            10        20
                    ....*....|....*....|....*....
gi 347971211   1035 GETPLHLAYQSGNKRCREILLESGADIYA 1063
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
654-727 5.35e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  654 ITDCLQRNLLH--VVHGSKEIADLLLSAEVPLEQQcvgQLNHWTPILVAIERKDWPLVDRLLAKGAKLST----GQTKLH 727
Cdd:COG0666   148 AQDNDGNTPLHlaAANGNLEIVKLLLEAGADVNAR---DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdndGKTALD 224
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1028-1107 9.89e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.06  E-value: 9.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  1028 ASCELRCGETPLHLAYQSGNKRCREILLESGADIYAK-------------SLRHGLTTLHFAiMGSAEREIIeQLLDVYG 1094
Cdd:TIGR00870  121 YTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffvksqgvdSFYHGESPLNAA-ACLGSPSIV-ALLSEDP 198

                           90
                   ....*....|...
gi 347971211  1095 FDVNTRDERGRTI 1107
Cdd:TIGR00870  199 ADILTADSLGNTL 211
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
805-1106 6.32e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.78  E-value: 6.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  805 NSALDNAVEDERFELARFLVERLHFDATDVFNELRQQYEQNPQFNDYKRLHSLCRDGEFAMVRQMIEEKCLDAQQEYDGS 884
Cdd:COG0666     9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  885 NIFIQAASSGNLELVQYLCEtHGflARIDDRDEHGFTAMRQAMVQGHQPIVLYLRKHNATVNpswmqqssnvsAVDDSei 964
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLE-AG--ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN-----------AQDND-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  965 dtedflaliacdrerlarlsidynryesGELLLHCYIRYvdePDEDTFRFLLAQYDNVDIRTDAscelrcGETPLHLAYQ 1044
Cdd:COG0666   153 ----------------------------GNTPLHLAAAN---GNLEIVKLLLEAGADVNARDND------GETPLHLAAE 195

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 347971211 1045 SGNKRCREILLESGADIYAKSlRHGLTTLHFAIMgsAEREIIEQLLDVYGFDVNTRDERGRT 1106
Cdd:COG0666   196 NGHLEIVKLLLEAGADVNAKD-NDGKTALDLAAE--NGNLEIVKLLLEAGADLNAKDKDGLT 254
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
970-1220 1.30e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.92  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  970 LALIACDRERLARLSIDYNRYESGELLLHCYIRYVDEPDEDTFRFLLAQYDNVDIRTDAscelrcGETPLHLAYQSGNKR 1049
Cdd:COG0666    28 AALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG------GNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1050 CREILLESGADIYAKSlRHGLTTLHFAIMGSAErEIIEQLLDvYGFDVNtrdergrtisfympvkselyrwlveryqfdp 1129
Cdd:COG0666   102 IVKLLLEAGADVNARD-KDGETPLHLAAYNGNL-EIVKLLLE-AGADVN------------------------------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1130 cAADNNGQTVLHHRVIKNsffaRAEI-EFLLQtLQVPQSHTDARGRLPLHYAVEADNCPIVRLLLKYRQDLcNVPDSEGL 1208
Cdd:COG0666   148 -AQDNDGNTPLHLAAANG----NLEIvKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV-NAKDNDGK 220

                         250
                  ....*....|..
gi 347971211 1209 TAVQVAQHLPHD 1220
Cdd:COG0666   221 TALDLAAENGNL 232
PHA03095 PHA03095
ankyrin-like protein; Provisional
 991-1214 1.30e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.31  E-value: 1.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  991 ESGELLLHCYIRYVDEPDEDTFRFLLAQYDNVDIRTdascelRCGETPLHLAYQSGNK-RCREILLESGADIYAKSlRHG 1069
Cdd:PHA03095   45 EYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNAPE------RCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKD-KVG 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1070 LTTLHFAIMG-SAEREIIEQLLDvYGFDVNTRDERGRTiSFYMPVKS-----ELYRWLVERyQFDPCAADNNGQTVLHHr 1143
Cdd:PHA03095  118 RTPLHVYLSGfNINPKVIRLLLR-KGADVNALDLYGMT-PLAVLLKSrnanvELLRLLIDA-GADVYAVDDRFRSLLHH- 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 347971211 1144 vIKNSFFARAEIEFLLQTLQVPQSHTDARGRLPLHYAVEADNCP---IVRLLLKYRQDlcNVPDSEGLTAVQVA 1214
Cdd:PHA03095  194 -HLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrslVLPLLIAGISI--NARNRYGQTPLHYA 264
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
980-1232 7.51e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 7.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  980 LARLSIDYNRYESGELLLHCYIRYVDEpdeDTFRFLLAQYDNVDIRTDAscelrcGETPLHLAYQSGNKRCREILLESGA 1059
Cdd:COG0666    74 LAAGADINAKDDGGNTLLHAAARNGDL---EIVKLLLEAGADVNARDKD------GETPLHLAAYNGNLEIVKLLLEAGA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1060 DIYAKSlRHGLTTLHFAIMGSAErEIIEQLLDvYGFDVNtrdergrtisfympvkselyrwlveryqfdpcAADNNGQTV 1139
Cdd:COG0666   145 DVNAQD-NDGNTPLHLAAANGNL-EIVKLLLE-AGADVN--------------------------------ARDNDGETP 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1140 LHHRVIKNsffaRAEI-EFLLQTLQVPqSHTDARGRLPLHYAVEADNCPIVRLLLKYRQDLcNVPDSEGLTAVQVAQHLP 1218
Cdd:COG0666   190 LHLAAENG----HLEIvKLLLEAGADV-NAKDNDGKTALDLAAENGNLEIVKLLLEAGADL-NAKDKDGLTALLLAAAAG 263

                         250
                  ....*....|....
gi 347971211 1219 HDSATCNLFRLLYK 1232
Cdd:COG0666   264 AALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
802-1090 5.34e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.92  E-value: 5.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  802 IFDNSALDNAVEDERFELARFLVERLHFDATDVFNELRQQYEQNPQFNDYKRLHSLCRDGEFAMVRQMIEEKCLDAQQEY 881
Cdd:COG0666    39 LLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  882 DGSNIFIQAASSGNLELVQYLCEtHGflARIDDRDEHGFTAMRQAMVQGHQPIVLYLRKHNATVNpswmqqssnvsavdd 961
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLLLE-AG--ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN--------------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  962 seidtedflaliacdrerlarlsidyNRYESGELLLHCYIRYvdePDEDTFRFLLAQYDNVDIRTDAscelrcGETPLHL 1041
Cdd:COG0666   181 --------------------------ARDNDGETPLHLAAEN---GHLEIVKLLLEAGADVNAKDND------GKTALDL 225

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 347971211 1042 AYQSGNKRCREILLESGADIYAKSLRHGLTTLHFAIMGSAEREIIEQLL 1090
Cdd:COG0666   226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 995-1214 5.78e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 59.68  E-value: 5.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  995 LLLHCYIRYVDEpdeDTFRFLLAQYDNVDIRTDAScelrcgETPLHLAYQSG-----NKRCREILLESGADIYAKSlRHG 1069
Cdd:PHA03100   37 LPLYLAKEARNI---DVVKILLDNGADINSSTKNN------STPLHYLSNIKynltdVKEIVKLLLEYGANVNAPD-NNG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1070 LTTLHFAIMG-SAEREIIEQLLDvYGFDVNTRDERGRTIsFYMPVKSelyrwlveryqfdpCAADNN-GQTVLHHRV--- 1144
Cdd:PHA03100  107 ITPLLYAISKkSNSYSIVEYLLD-NGANVNIKNSDGENL-LHLYLES--------------NKIDLKiLKLLIDKGVdin 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1145 IKNSffaraeIEFLLqTLQVPQSHTDARGRLPLHYAVEADNCPIVRLLLKYRQDLcNVPDSEGLTAVQVA 1214
Cdd:PHA03100  171 AKNR------VNYLL-SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANP-NLVNKYGDTPLHIA 232
Ank_2 pfam12796
Ankyrin repeats (3 copies);
854-946 1.99e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 1.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211   854 LHSLCRDGEFAMVRQMIEEKCLDAQQEYDGSNIFIQAASSGNLELVQYLCEThgflARIDDRDeHGFTAMRQAMVQGHQP 933
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH----ADVNLKD-NGRTALHYAARSGHLE 75

                           90
                   ....*....|...
gi 347971211   934 IVLYLRKHNATVN 946
Cdd:pfam12796   76 IVKLLLEKGADIN 88
Ank_5 pfam13857
Ankyrin repeats (many copies);
1158-1214 2.90e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.19  E-value: 2.90e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 347971211  1158 LLQTLQVPQSHTDARGRLPLHYAVEADNCPIVRLLLKYRQDlCNVPDSEGLTAVQVA 1214
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVD-LNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 955-1148 5.51e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 5.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  955 NVSAVDDSEIDTEDFLALIacdRERLARLSIDYNR------YESGELLLHcYIryVDEPDEDTFRFLLAQYDNVDIRTda 1028
Cdd:PHA02878  127 NIQTIDLVYIDKKSKDDII---EAEITKLLLSYGAdinmkdRHKGNTALH-YA--TENKDQRLTELLLSYGANVNIPD-- 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1029 scelRCGETPLHLAYQSGNKRCREILLESGADIYAKSLrHGLTTLHFAIMGSAEREIIEQLLDvYGFDVNTRDE-RGRTi 1107
Cdd:PHA02878  199 ----KTNNSPLHHAVKHYNKPIVHILLENGASTDARDK-CGNTPLHISVGYCKDYDILKLLLE-HGVDVNAKSYiLGLT- 271

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 347971211 1108 SFYMPVKSELYRWLVERYQFDPCAADNNGQTVLHHRVIKNS 1148
Cdd:PHA02878  272 ALHSSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYL 312
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1008-1101 2.14e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 2.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  1008 DEDTFRFLLAQydnvdiRTDASCELRCGETPLHLAYQSGNKRCREILLESGAdiyAKSLRHGLTTLHFAIMgSAEREIIE 1087
Cdd:pfam12796    9 NLELVKLLLEN------GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAAR-SGHLEIVK 78

                           90
                   ....*....|....
gi 347971211  1088 QLLDvYGFDVNTRD 1101
Cdd:pfam12796   79 LLLE-KGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1119-1204 4.86e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 4.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  1119 RWLVErYQFDPCAADNNGQTVLHHRVIKNSFFAraeIEFLLQTLQVpqsHTDARGRLPLHYAVEADNCPIVRLLLKYRQD 1198
Cdd:pfam12796   14 KLLLE-NGADANLQDKNGRTALHLAAKNGHLEI---VKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGAD 86


                   ....*.
gi 347971211  1199 lCNVPD 1204
Cdd:pfam12796   87 -INVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 893-1214 4.11e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.65  E-value: 4.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  893 SGNLELVQYLCETHGFLARIDDrdEHGFTAMRQAMVQGHQPIVLYLRKHNATVNpswmQQSSNVSavddseidtEDFLAL 972
Cdd:PHA02874   11 SGDIEAIEKIIKNKGNCINISV--DETTTPLIDAIRSGDAKIVELFIKHGADIN----HINTKIP---------HPLLTA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  973 IACDRERLARLSIDyNRYESGELLLHCYiryvdepDEDTFRFLLAQYDNVDIRTDAScelrcgETPLHLAYQSGNKRCRE 1052
Cdd:PHA02874   76 IKIGAHDIIKLLID-NGVDTSILPIPCI-------EKDMIKTILDCGIDVNIKDAEL------KTFLHYAIKKGDLESIK 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1053 ILLESGADIYAKSLrHGLTTLHFAIMgSAEREIIEQLLDvYGFDVNTRDERGRTiSFYMPVKSELYRWLveRYQFD---- 1128
Cdd:PHA02874  142 MLFEYGADVNIEDD-NGCYPIHIAIK-HNFFDIIKLLLE-KGAYANVKDNNGES-PLHNAAEYGDYACI--KLLIDhgnh 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1129 ---PCaadNNGQTVLHHRVIKNsffaRAEIEFLLQTLQVpqSHTDARGRLPLHYAVEAD-NCPIVRLLLKYRQDLcNVPD 1204
Cdd:PHA02874  216 imnKC---KNGFTPLHNAIIHN----RSAIELLINNASI--NDQDIDGSTPLHHAINPPcDIDIIDILLYHKADI-SIKD 285

                         330
                  ....*....|
gi 347971211 1205 SEGLTAVQVA 1214
Cdd:PHA02874  286 NKGENPIDTA 295
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 1036-1141 2.53e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.57  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1036 ETPLH--LAYQSGNKRCREILLESGADIYAKSLRHGLTTLHF--AIMGSAEREIIEQLLDVyGFDVNTRDERGRT-ISFY 1110
Cdd:PHA02859   52 ETPIFscLEKDKVNVEILKFLIENGADVNFKTRDNNLSALHHylSFNKNVEPEILKILIDS-GSSITEEDEDGKNlLHMY 130

                          90       100       110
                  ....*....|....*....|....*....|....
gi 347971211 1111 M---PVKSELYRWLVErYQFDPCAADNNGQTVLH 1141
Cdd:PHA02859  131 McnfNVRINVIKLLID-SGVSFLNKDFDNNNILY 163
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1035-1063 3.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.78e-03
                            10        20
                    ....*....|....*....|....*....
gi 347971211   1035 GETPLHLAYQSGNKRCREILLESGADIYA 1063
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
654-727 5.35e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  654 ITDCLQRNLLH--VVHGSKEIADLLLSAEVPLEQQcvgQLNHWTPILVAIERKDWPLVDRLLAKGAKLST----GQTKLH 727
Cdd:COG0666   148 AQDNDGNTPLHlaAANGNLEIVKLLLEAGADVNAR---DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdndGKTALD 224
PHA02946 PHA02946
ankyin-like protein; Provisional
 1035-1193 5.75e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.81  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1035 GETPLHLAYQSGNKRCREILLESGADIYAKSlRHGLTTLHFaiMGSAEREIIEQ--LLDVYGFDVNTR-DERGRTISFYM 1111
Cdd:PHA02946   72 GNYPLHIASKINNNRIVAMLLTHGADPNACD-KQHKTPLYY--LSGTDDEVIERinLLVQYGAKINNSvDEEGCGPLLAC 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211 1112 PVKSELYRWLVERYQFDPCAADNNGQTVLHHRVIKNSffARAEIEFLLQTLQVPQSHTDARGRLPLHYAVE--ADNCPIV 1189
Cdd:PHA02946  149 TDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDN--PKASTISWMMKLGISPSKPDHDGNTPLHIVCSktVKNVDII 226


                  ....
gi 347971211 1190 RLLL 1193
Cdd:PHA02946  227 NLLL 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1039-1106 6.44e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 6.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 347971211  1039 LHLAYQSGNKRCREILLESGADIYAKSLRhGLTTLHFAIMGSAErEIIEQLLDVygFDVNTRDErGRT 1106
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHL-EIVKLLLEH--ADVNLKDN-GRT 63
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1177-1214 8.14e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 8.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 347971211  1177 LHYAVEADNCPIVRLLLKYRQDlCNVPDSEGLTAVQVA 1214
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGAD-ANLQDKNGRTALHLA 37
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1028-1107 9.89e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 40.06  E-value: 9.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347971211  1028 ASCELRCGETPLHLAYQSGNKRCREILLESGADIYAK-------------SLRHGLTTLHFAiMGSAEREIIeQLLDVYG 1094
Cdd:TIGR00870  121 YTSEFTPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffvksqgvdSFYHGESPLNAA-ACLGSPSIV-ALLSEDP 198

                           90
                   ....*....|...
gi 347971211  1095 FDVNTRDERGRTI 1107
Cdd:TIGR00870  199 ADILTADSLGNTL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH