|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
64-302 |
4.90e-102 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 323.54 E-value: 4.90e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 64 NFTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRLTlntvgsdaalppnaddevdaasgnkeyaNSPTN 143
Cdd:cd18023 1 YFNRIQSEVFPDLLYSDKNFVVSAPTGSGKTVLFELAILRLLKERNP----------------------------LPWGN 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 144 RKAVYICPMKALAFEKYTQWRERFP--ALSVVMETGDQEAMRTvdaimDEVFQTDIIITTPERWDGITRRWKEGVvwNLV 221
Cdd:cd18023 53 RKVVYIAPIKALCSEKYDDWKEKFGplGLSCAELTGDTEMDDT-----FEIQDADIILTTPEKWDSMTRRWRDNG--NLV 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 222 ASVALLMLDEVHTVSEERGAALEAVVSRMKAIKLSMTTRGPQVCRTRFVAISGTLPNIEDFAEWLQVPPAGVFSFTSADR 301
Cdd:cd18023 126 QLVALVLIDEVHIIKENRGATLEVVVSRMKTLSSSSELRGSTVRPMRFVAVSATIPNIEDLAEWLGDNPAGCFSFGESFR 205
|
.
gi 74025910 302 P 302
Cdd:cd18023 206 P 206
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
65-549 |
1.21e-89 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 301.43 E-value: 1.21e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 65 FTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKdrltlntvgsdaalppnaddevdaasgnkeyanspTNR 144
Cdd:COG1204 23 LYPPQAEALEAGLLEGKNLVVSAPTASGKTLIAELAILKALL-----------------------------------NGG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 145 KAVYICPMKALAFEKYTQWRERFPAL--SVVMETGDqeamrtVDAIMDEVFQTDIIITTPERWDGITRRwkegvVWNLVA 222
Cdd:COG1204 68 KALYIVPLRALASEKYREFKRDFEELgiKVGVSTGD------YDSDDEWLGRYDILVATPEKLDSLLRN-----GPSWLR 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 223 SVALLMLDEVHTV-SEERGAALEAVVSRMKaiklsmtTRGPQVcrtRFVAISGTLPNIEDFAEWLQVPPagvfsFTSADR 301
Cdd:COG1204 137 DVDLVVVDEAHLIdDESRGPTLEVLLARLR-------RLNPEA---QIVALSATIGNAEEIAEWLDAEL-----VKSDWR 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 302 PLPLTLRVVSypstsSNPFAFD---RFLTLKLFGLIRR-YSEGRPTLVFCASRGETMNSARRITEELNEAAAREGCERQL 377
Cdd:COG1204 202 PVPLNEGVLY-----DGVLRFDdgsRRSKDPTLALALDlLEEGGQVLVFVSSRRDAESLAKKLADELKRRLTPEEREELE 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 378 CASEEVQRLA-SSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTtffK 456
Cdd:COG1204 277 ELAEELLEVSeETHTNEKLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDT---K 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 457 NGNRDDLPLSEIAQMSGRAGRPGLDTHGVALVLTTDDKAY--LYKPLQHGDTcTTVESRLHQ--NMIEHVNAEVALRTIH 532
Cdd:COG1204 354 RGGMVPIPVLEFKQMAGRAGRPGYDPYGEAILVAKSSDEAdeLFERYILGEP-EPIRSKLANesALRTHLLALIASGFAN 432
|
490
....*....|....*..
gi 74025910 533 NLSLGVEWIKTTFFWIR 549
Cdd:COG1204 433 SREELLDFLENTFYAYQ 449
|
|
| Sec63 |
smart00973 |
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl ... |
637-978 |
1.99e-52 |
|
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
Pssm-ID: 214946 Cd Length: 314 Bit Score: 187.18 E-value: 1.99e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 637 STRVGRAMARRYILFKTVETLNRELlhrfshqsgrqgapqimgaamaeeegqiqqktGESFTLHQVLRVFCHSSEFDGLR 716
Cdd:smart00973 1 PTELGRIASYYYISYETIETFNQSL--------------------------------KPTTTLKDILEILSRASEFKEIP 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 717 LRQGDKKHLNELNKVIRFPLNCGmrggreVREDWH-KVYVLIQAHLDRVAVSDFSLRNDCVRLWTVAPRVARFVVDYATT 795
Cdd:smart00973 49 VRHNEKKELNELNKRVPIPVKEG------IIDSPHaKVNLLLQAHLSRLPLPDFDLVSDLKYILQNAPRILRALVDIALS 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 796 HPCFSLIQQSSLLCRCIEQGTWWDGL-IIKQIEG--IGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNPPFGTDLQE 872
Cdd:smart00973 123 KGWLRTALNALDLSQMVVQRLWEDSDsPLKQLPHflIEDVYDKLELKDGSRSFELLLDMNAAELGEFLNRLPPNGRLIYE 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 873 KCHSRPMYNLALEHVTEAGTVRVVVSYKAGVSTRRDPPLEQCHMILLVGDLELDRTHLLRQIDCRTANRRP------LVF 946
Cdd:smart00973 203 LLRRFPKIEVEAEVLPITRDLTLRVELEITPVFAWDLPRHKGKSESWWLVVGDSDTNELLAIKRVTLRKKKksnevkLDF 282
|
330 340 350
....*....|....*....|....*....|..
gi 74025910 947 TFQVSPGYRGQIMGSLTNGNFLGNDCNATLKV 978
Cdd:smart00973 283 TVPLSEPGPENYTVYLISDSYLGCDQEVSFSL 314
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
301-491 |
3.81e-51 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 177.36 E-value: 3.81e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 301 RPLPLTLRVVSYPSTSSNPFAFDRFLT---LKLFGLIRRYSEGRPTLVFCASRGETMNSARRiteelneaaaregcerql 377
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKFdsdIIVLLKIETVSEGKPVLVFCSSRKECEKTAKD------------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 378 caseevqrlassandkqlrtmlLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTTFFKN 457
Cdd:cd18795 63 ----------------------LAGIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDG 120
|
170 180 190
....*....|....*....|....*....|....
gi 74025910 458 GNRDDLPLSEIAQMSGRAGRPGLDTHGVALVLTT 491
Cdd:cd18795 121 KGYRELSPLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
77-496 |
5.71e-43 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 168.52 E-value: 5.71e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 77 IQNDFNVVVAAPTGSGKTALLEAAMLRLFKdrltlntvgsdaalppnaddevdaasgnkeyanspTNRKAVYICPMKALA 156
Cdd:PRK01172 34 LRKGENVIVSVPTAAGKTLIAYSAIYETFL-----------------------------------AGLKSIYIVPLRSLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 157 FEKYTQW-RERFPALSVVMETGDqeamrtVDAIMDEVFQTDIIITTPERWDGITRRWKEgvvwnLVASVALLMLDEVHTV 235
Cdd:PRK01172 79 MEKYEELsRLRSLGMRVKISIGD------YDDPPDFIKRYDVVILTSEKADSLIHHDPY-----IINDVGLIVADEIHII 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 236 SEE-RGAALEAVVSRMKAIKlsmttrgPQvcrTRFVAISGTLPNIEDFAEWLQVPpagvfSFTSADRPLPLTLRVVSYPS 314
Cdd:PRK01172 148 GDEdRGPTLETVLSSARYVN-------PD---ARILALSATVSNANELAQWLNAS-----LIKSNFRPVPLKLGILYRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 315 TSSNPfafDRFLTLKLFGLIRR-YSEGRPTLVFCASRGETMNSARRITEELNEAAaregcerqlcaseEVQRLASSAN-- 391
Cdd:PRK01172 213 LILDG---YERSQVDINSLIKEtVNDGGQVLVFVSSRKNAEDYAEMLIQHFPEFN-------------DFKVSSENNNvy 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 392 DKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTTFFKNGNRDDLPLSEIAQM 471
Cdd:PRK01172 277 DDSLNEMLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQM 356
|
410 420
....*....|....*....|....*
gi 74025910 472 SGRAGRPGLDTHGVALVLTTDDKAY 496
Cdd:PRK01172 357 IGRAGRPGYDQYGIGYIYAASPASY 381
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
69-493 |
3.37e-42 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 167.04 E-value: 3.37e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 69 QERVIPAIIQNDfNVVVAAPTGSGKTALLEAAMLRlfkdrltlntvgsdaALppnaddevdaASGnkeyansptnRKAVY 148
Cdd:COG4581 30 QEEAILALEAGR-SVLVAAPTGSGKTLVAEFAIFL---------------AL----------ARG----------RRSFY 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 149 ICPMKALAFEKYTQWRERFPALSVVMETGDqeamRTV--DAimdevfqtDIIITTPErwdgITRRWKEGVVWNLvASVAL 226
Cdd:COG4581 74 TAPIKALSNQKFFDLVERFGAENVGLLTGD----ASVnpDA--------PIVVMTTE----ILRNMLYREGADL-EDVGV 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 227 LMLDEVHTVSE-ERGAALEAVVsrmkaIKLsmttrgPQvcRTRFVAISGTLPNIEDFAEWLQV---PPAGVfsfTSADRP 302
Cdd:COG4581 137 VVMDEFHYLADpDRGWVWEEPI-----IHL------PA--RVQLVLLSATVGNAEEFAEWLTRvrgETAVV---VSEERP 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 303 LPLTLRVVSyPSTSSNPFAFDRFL--TLKLFGLIRRYSEGR--PTLVFCASRGETMNSARRIteelneAAARegcerqLC 378
Cdd:COG4581 201 VPLEFHYLV-TPRLFPLFRVNPELlrPPSRHEVIEELDRGGllPAIVFIFSRRGCDEAAQQL------LSAR------LT 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 379 ASEEVQRLA----------SSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVI 448
Cdd:COG4581 268 TKEERAEIReaidefaedfSVLFGKTLSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVV 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 74025910 449 VKGTTFFkNGNRD-DLPLSEIAQMSGRAGRPGLDTHGVALVLTTDD 493
Cdd:COG4581 348 FTKLSKF-DGERHrPLTAREFHQIAGRAGRRGIDTEGHVVVLAPEH 392
|
|
| Sec63 |
pfam02889 |
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of ... |
637-952 |
1.15e-32 |
|
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Pssm-ID: 460740 Cd Length: 307 Bit Score: 129.63 E-value: 1.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 637 STRVGRAMARRYILFKTVETLNRELlhrfshqsgrqgapqimgaamaeeegqiqqktGESFTLHQVLRVFCHSSEFDGLR 716
Cdd:pfam02889 1 PTDLGRIASHYYISYETIETFNQSL--------------------------------KPNTTLADLLRILSSASEFEQIP 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 717 LRQGDKKHLNELNKVIRFPLncgmrggREVREDWH-KVYVLIQAHLDRVAVSDFSLRNDCVRLWTVAPRVARFVVDYATT 795
Cdd:pfam02889 49 VRQEEKKELKKLLEKVPIPV-------KGDIEDPHaKVNILLQAYISRLKLPGFALVSDMNYILQNAGRILRALFEILLS 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 796 HPCFSLIQQSSLLCRCIEQGTWWDGLIIKQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNPPFGTDLQEKCH 875
Cdd:pfam02889 122 KGWLSAALTALDLCKMIEQRMWDSDSPLRQFPGIPPELIKKLEKKGVESVRDILELDDAEELGELIRNPKMGKDIAQFVN 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 876 SRPMYNLALE---HVTEAGTVRVVVsykagvsTRRDPPLEQCHMI-----LLVGDLELDRTHLLRQID-CRTANRRPLVF 946
Cdd:pfam02889 202 RFPKIEIEAEvqpITRSVLRVEVTI-------TPDFPWDKRVHGKsegfwLVVGDSDGNEILHIERFTlTKRTLAGEHKL 274
|
....*.
gi 74025910 947 TFQVSP 952
Cdd:pfam02889 275 EFTVPP 280
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
66-282 |
7.14e-25 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 102.32 E-value: 7.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 66 TRVQERVIPAIIQNDfNVVVAAPTGSGKTALLEAAMLRLFKDRLTlntvgsdaalppnaddevdaasgnkeyansptNRK 145
Cdd:pfam00270 1 TPIQAEAIPAILEGR-DVLVQAPTGSGKTLAFLLPALEALDKLDN--------------------------------GPQ 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 146 AVYICPMKALAFEKYTQWRERF--PALSVVMETGDQEamrtVDAIMDEVFQTDIIITTPERWDGITRRWKegvvwnLVAS 223
Cdd:pfam00270 48 ALVLAPTRELAEQIYEELKKLGkgLGLKVASLLGGDS----RKEQLEKLKGPDILVGTPGRLLDLLQERK------LLKN 117
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74025910 224 VALLMLDEVHTVSEE-RGAALEAVVSRMKAIKlsmttrgpqvcrtRFVAISGTLP-NIEDF 282
Cdd:pfam00270 118 LKLLVLDEAHRLLDMgFGPDLEEILRRLPKKR-------------QILLLSATLPrNLEDL 165
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
58-286 |
3.75e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.94 E-value: 3.75e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 58 SYFPHTNFTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRLtlntvgsdaalppnaddevdaasgnkey 137
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGK---------------------------- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 138 ansptNRKAVYICPMKALAFEKYTQWRERFP--ALSVVMETGDQEAMRTVDAIMDEVfqTDIIITTPERWDGITRRWKEG 215
Cdd:smart00487 54 -----GGRVLVLVPTRELAEQWAEELKKLGPslGLKVVGLYGGDSKREQLRKLESGK--TDILVTTPGRLLDLLENDKLS 126
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74025910 216 VVWnlvasVALLMLDEVHTVSE-ERGAALEAVVSRMKAIKlsmttrgpqvcrtRFVAISGTLPNIEDFAEWL 286
Cdd:smart00487 127 LSN-----VDLVILDEAHRLLDgGFGDQLEKLLKLLPKNV-------------QLLLLSATPPEEIENLLEL 180
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
401-479 |
1.92e-10 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 58.38 E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 401 LGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLP-AHLVIVKGTtffkngnrdDLPLSEIAQMSGRAGRPG 479
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYIQRIGRAGRAG 82
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
85-486 |
1.98e-09 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 62.63 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 85 VAAPTGSGKT-ALLEAAMLRLFKDRltlntvgsdaalppnaddevdaASGNKEYANSPTNRkAVYICPMKALA------- 156
Cdd:PRK09751 1 VIAPTGSGKTlAAFLYALDRLFREG----------------------GEDTREAHKRKTSR-ILYISPIKALGtdvqrnl 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 157 ---FEKYTQWRERFPALSVVMETGdqeaMRTVDAIMDEVFQ-----TDIIITTPER-WDGITRRWKEGvvwnlVASVALL 227
Cdd:PRK09751 58 qipLKGIADERRRRGETEVNLRVG----IRTGDTPAQERSKltrnpPDILITTPESlYLMLTSRARET-----LRGVETV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 228 MLDEVHTVS-EERGAALEAVVSRMKAIKLSMTTRgpqvcrtrfVAISGTLPNIEDFAEWL-QVPPAGVFSFTSADRPlpl 305
Cdd:PRK09751 129 IIDEVHAVAgSKRGAHLALSLERLDALLHTSAQR---------IGLSATVRSASDVAAFLgGDRPVTVVNPPAMRHP--- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 306 TLRVV-------SYPSTSSNPFAFDR------FLTLKLFGLIRRYSEGRPTLVFCASRGetmnSARRITEELNEA-AARE 371
Cdd:PRK09751 197 QIRIVvpvanmdDVSSVASGTGEDSHagregsIWPYIETGILDEVLRHRSTIVFTNSRG----LAEKLTARLNELyAARL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 372 GCERQLCASEEVQRLASSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPA-HLVIVK 450
Cdd:PRK09751 273 QRSPSIAVDAAHFESTSGATSNRVQSSDVFIARSHHGSVSKEQRAITEQALKSGELRCVVATSSLELGIDMGAvDLVIQV 352
|
410 420 430
....*....|....*....|....*....|....*.
gi 74025910 451 GTtffkngnrddlPLSeIAQMSGRAGRPGLDTHGVA 486
Cdd:PRK09751 353 AT-----------PLS-VASGLQRIGRAGHQVGGVS 376
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
388-479 |
7.94e-07 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 49.13 E-value: 7.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 388 SSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLP-AHLVIvkgttFFkngnrdDLP-- 464
Cdd:pfam00271 26 KTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVI-----NY------DLPwn 94
|
90
....*....|....*
gi 74025910 465 LSEIAQMSGRAGRPG 479
Cdd:pfam00271 95 PASYIQRIGRAGRAG 109
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
821-878 |
1.11e-03 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 43.09 E-value: 1.11e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74025910 821 LIIKQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNppfGTDLQEKC---HSRP 878
Cdd:PRK01810 179 LPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGIN---GVRLQRRAngiDDRP 236
|
|
| H3TH |
COG3743 |
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain ... |
824-859 |
2.01e-03 |
|
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain [Replication, recombination and repair];
Pssm-ID: 442957 [Multi-domain] Cd Length: 92 Bit Score: 38.76 E-value: 2.01e-03
10 20 30
....*....|....*....|....*....|....*.
gi 74025910 824 KQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEAL 859
Cdd:COG3743 26 KKIKGIGPKIEKKLNELGIFTFAQIAAWTPEDIAWV 61
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
64-302 |
4.90e-102 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 323.54 E-value: 4.90e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 64 NFTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRLTlntvgsdaalppnaddevdaasgnkeyaNSPTN 143
Cdd:cd18023 1 YFNRIQSEVFPDLLYSDKNFVVSAPTGSGKTVLFELAILRLLKERNP----------------------------LPWGN 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 144 RKAVYICPMKALAFEKYTQWRERFP--ALSVVMETGDQEAMRTvdaimDEVFQTDIIITTPERWDGITRRWKEGVvwNLV 221
Cdd:cd18023 53 RKVVYIAPIKALCSEKYDDWKEKFGplGLSCAELTGDTEMDDT-----FEIQDADIILTTPEKWDSMTRRWRDNG--NLV 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 222 ASVALLMLDEVHTVSEERGAALEAVVSRMKAIKLSMTTRGPQVCRTRFVAISGTLPNIEDFAEWLQVPPAGVFSFTSADR 301
Cdd:cd18023 126 QLVALVLIDEVHIIKENRGATLEVVVSRMKTLSSSSELRGSTVRPMRFVAVSATIPNIEDLAEWLGDNPAGCFSFGESFR 205
|
.
gi 74025910 302 P 302
Cdd:cd18023 206 P 206
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
65-549 |
1.21e-89 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 301.43 E-value: 1.21e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 65 FTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKdrltlntvgsdaalppnaddevdaasgnkeyanspTNR 144
Cdd:COG1204 23 LYPPQAEALEAGLLEGKNLVVSAPTASGKTLIAELAILKALL-----------------------------------NGG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 145 KAVYICPMKALAFEKYTQWRERFPAL--SVVMETGDqeamrtVDAIMDEVFQTDIIITTPERWDGITRRwkegvVWNLVA 222
Cdd:COG1204 68 KALYIVPLRALASEKYREFKRDFEELgiKVGVSTGD------YDSDDEWLGRYDILVATPEKLDSLLRN-----GPSWLR 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 223 SVALLMLDEVHTV-SEERGAALEAVVSRMKaiklsmtTRGPQVcrtRFVAISGTLPNIEDFAEWLQVPPagvfsFTSADR 301
Cdd:COG1204 137 DVDLVVVDEAHLIdDESRGPTLEVLLARLR-------RLNPEA---QIVALSATIGNAEEIAEWLDAEL-----VKSDWR 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 302 PLPLTLRVVSypstsSNPFAFD---RFLTLKLFGLIRR-YSEGRPTLVFCASRGETMNSARRITEELNEAAAREGCERQL 377
Cdd:COG1204 202 PVPLNEGVLY-----DGVLRFDdgsRRSKDPTLALALDlLEEGGQVLVFVSSRRDAESLAKKLADELKRRLTPEEREELE 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 378 CASEEVQRLA-SSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTtffK 456
Cdd:COG1204 277 ELAEELLEVSeETHTNEKLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDT---K 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 457 NGNRDDLPLSEIAQMSGRAGRPGLDTHGVALVLTTDDKAY--LYKPLQHGDTcTTVESRLHQ--NMIEHVNAEVALRTIH 532
Cdd:COG1204 354 RGGMVPIPVLEFKQMAGRAGRPGYDPYGEAILVAKSSDEAdeLFERYILGEP-EPIRSKLANesALRTHLLALIASGFAN 432
|
490
....*....|....*..
gi 74025910 533 NLSLGVEWIKTTFFWIR 549
Cdd:COG1204 433 SREELLDFLENTFYAYQ 449
|
|
| Sec63 |
smart00973 |
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl ... |
637-978 |
1.99e-52 |
|
Sec63 Brl domain; This domain was named after the yeast Sec63 (or NPL1) (also known as the Brl domain) protein in which it was found. This protein is required for assembly of functional endoplasmic reticulum translocons. Other yeast proteins containing this domain include pre-mRNA splicing helicase BRR2, HFM1 protein and putative helicases.
Pssm-ID: 214946 Cd Length: 314 Bit Score: 187.18 E-value: 1.99e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 637 STRVGRAMARRYILFKTVETLNRELlhrfshqsgrqgapqimgaamaeeegqiqqktGESFTLHQVLRVFCHSSEFDGLR 716
Cdd:smart00973 1 PTELGRIASYYYISYETIETFNQSL--------------------------------KPTTTLKDILEILSRASEFKEIP 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 717 LRQGDKKHLNELNKVIRFPLNCGmrggreVREDWH-KVYVLIQAHLDRVAVSDFSLRNDCVRLWTVAPRVARFVVDYATT 795
Cdd:smart00973 49 VRHNEKKELNELNKRVPIPVKEG------IIDSPHaKVNLLLQAHLSRLPLPDFDLVSDLKYILQNAPRILRALVDIALS 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 796 HPCFSLIQQSSLLCRCIEQGTWWDGL-IIKQIEG--IGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNPPFGTDLQE 872
Cdd:smart00973 123 KGWLRTALNALDLSQMVVQRLWEDSDsPLKQLPHflIEDVYDKLELKDGSRSFELLLDMNAAELGEFLNRLPPNGRLIYE 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 873 KCHSRPMYNLALEHVTEAGTVRVVVSYKAGVSTRRDPPLEQCHMILLVGDLELDRTHLLRQIDCRTANRRP------LVF 946
Cdd:smart00973 203 LLRRFPKIEVEAEVLPITRDLTLRVELEITPVFAWDLPRHKGKSESWWLVVGDSDTNELLAIKRVTLRKKKksnevkLDF 282
|
330 340 350
....*....|....*....|....*....|..
gi 74025910 947 TFQVSPGYRGQIMGSLTNGNFLGNDCNATLKV 978
Cdd:smart00973 283 TVPLSEPGPENYTVYLISDSYLGCDQEVSFSL 314
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
301-491 |
3.81e-51 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 177.36 E-value: 3.81e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 301 RPLPLTLRVVSYPSTSSNPFAFDRFLT---LKLFGLIRRYSEGRPTLVFCASRGETMNSARRiteelneaaaregcerql 377
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKFdsdIIVLLKIETVSEGKPVLVFCSSRKECEKTAKD------------------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 378 caseevqrlassandkqlrtmlLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTTFFKN 457
Cdd:cd18795 63 ----------------------LAGIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDG 120
|
170 180 190
....*....|....*....|....*....|....
gi 74025910 458 GNRDDLPLSEIAQMSGRAGRPGLDTHGVALVLTT 491
Cdd:cd18795 121 KGYRELSPLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
65-296 |
6.72e-45 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 161.00 E-value: 6.72e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 65 FTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRltlntvgsdaalppnaddevdaasgnkeyansPTNr 144
Cdd:cd18022 2 FNPIQTQVFHTLYHTDNNVLLGAPTGSGKTIAAELAMFRAFNKY--------------------------------PGS- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 145 KAVYICPMKALAFEKYTQWRERFPA---LSVVMETGDQeamrTVDaiMDEVFQTDIIITTPERWDGITRRWKegvVWNLV 221
Cdd:cd18022 49 KVVYIAPLKALVRERVDDWKKRFEEklgKKVVELTGDV----TPD--MKALADADIIITTPEKWDGISRSWQ---TREYV 119
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74025910 222 ASVALLMLDEVHTVSEERGAALEAVVSRMKAIklSMTTRGPqvcrTRFVAISGTLPNIEDFAEWLQVPPAGVFSF 296
Cdd:cd18022 120 QQVSLIIIDEIHLLGSDRGPVLEVIVSRMNYI--SSQTEKP----VRLVGLSTALANAGDLANWLGIKKMGLFNF 188
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
77-496 |
5.71e-43 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 168.52 E-value: 5.71e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 77 IQNDFNVVVAAPTGSGKTALLEAAMLRLFKdrltlntvgsdaalppnaddevdaasgnkeyanspTNRKAVYICPMKALA 156
Cdd:PRK01172 34 LRKGENVIVSVPTAAGKTLIAYSAIYETFL-----------------------------------AGLKSIYIVPLRSLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 157 FEKYTQW-RERFPALSVVMETGDqeamrtVDAIMDEVFQTDIIITTPERWDGITRRWKEgvvwnLVASVALLMLDEVHTV 235
Cdd:PRK01172 79 MEKYEELsRLRSLGMRVKISIGD------YDDPPDFIKRYDVVILTSEKADSLIHHDPY-----IINDVGLIVADEIHII 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 236 SEE-RGAALEAVVSRMKAIKlsmttrgPQvcrTRFVAISGTLPNIEDFAEWLQVPpagvfSFTSADRPLPLTLRVVSYPS 314
Cdd:PRK01172 148 GDEdRGPTLETVLSSARYVN-------PD---ARILALSATVSNANELAQWLNAS-----LIKSNFRPVPLKLGILYRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 315 TSSNPfafDRFLTLKLFGLIRR-YSEGRPTLVFCASRGETMNSARRITEELNEAAaregcerqlcaseEVQRLASSAN-- 391
Cdd:PRK01172 213 LILDG---YERSQVDINSLIKEtVNDGGQVLVFVSSRKNAEDYAEMLIQHFPEFN-------------DFKVSSENNNvy 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 392 DKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTTFFKNGNRDDLPLSEIAQM 471
Cdd:PRK01172 277 DDSLNEMLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQM 356
|
410 420
....*....|....*....|....*
gi 74025910 472 SGRAGRPGLDTHGVALVLTTDDKAY 496
Cdd:PRK01172 357 IGRAGRPGYDQYGIGYIYAASPASY 381
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
82-494 |
1.98e-42 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 167.30 E-value: 1.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 82 NVVVAAPTGSGKTALLEAAML-RLFKDrltlntvgsdaalppnaddevdaasgnkeyansptNRKAVYICPMKALAFEKY 160
Cdd:PRK00254 41 NLVLAIPTASGKTLVAEIVMVnKLLRE-----------------------------------GGKAVYLVPLKALAEEKY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 161 TQWR--ERFpALSVVMETGDqeamrtVDAIMDEVFQTDIIITTPERWDGITRrwkEGVVWnlVASVALLMLDEVHTV-SE 237
Cdd:PRK00254 86 REFKdwEKL-GLRVAMTTGD------YDSTDEWLGKYDIIIATAEKFDSLLR---HGSSW--IKDVKLVVADEIHLIgSY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 238 ERGAALEAVVSRMkaiklsmttrgpqVCRTRFVAISGTLPNIEDFAEWLQVppagvfSFTSAD-RPLPLTLRVVSYPSTS 316
Cdd:PRK00254 154 DRGATLEMILTHM-------------LGRAQILGLSATVGNAEELAEWLNA------ELVVSDwRPVKLRKGVFYQGFLF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 317 SNPFAFDRFLTLKLFGLIRRYSEGRPTLVFCASRgetmNSARRITEELNEAAAREGCERQLCASEEV-QRLASSANDKQL 395
Cdd:PRK00254 215 WEDGKIERFPNSWESLVYDAVKKGKGALVFVNTR----RSAEKEALELAKKIKRFLTKPELRALKELaDSLEENPTNEKL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 396 RTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVKGTTFFKNGNRDDLPLSEIAQMSGRA 475
Cdd:PRK00254 291 KKALRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFGWEDIPVLEIQQMMGRA 370
|
410
....*....|....*....
gi 74025910 476 GRPGLDTHGVALVLTTDDK 494
Cdd:PRK00254 371 GRPKYDEVGEAIIVATTEE 389
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
69-493 |
3.37e-42 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 167.04 E-value: 3.37e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 69 QERVIPAIIQNDfNVVVAAPTGSGKTALLEAAMLRlfkdrltlntvgsdaALppnaddevdaASGnkeyansptnRKAVY 148
Cdd:COG4581 30 QEEAILALEAGR-SVLVAAPTGSGKTLVAEFAIFL---------------AL----------ARG----------RRSFY 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 149 ICPMKALAFEKYTQWRERFPALSVVMETGDqeamRTV--DAimdevfqtDIIITTPErwdgITRRWKEGVVWNLvASVAL 226
Cdd:COG4581 74 TAPIKALSNQKFFDLVERFGAENVGLLTGD----ASVnpDA--------PIVVMTTE----ILRNMLYREGADL-EDVGV 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 227 LMLDEVHTVSE-ERGAALEAVVsrmkaIKLsmttrgPQvcRTRFVAISGTLPNIEDFAEWLQV---PPAGVfsfTSADRP 302
Cdd:COG4581 137 VVMDEFHYLADpDRGWVWEEPI-----IHL------PA--RVQLVLLSATVGNAEEFAEWLTRvrgETAVV---VSEERP 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 303 LPLTLRVVSyPSTSSNPFAFDRFL--TLKLFGLIRRYSEGR--PTLVFCASRGETMNSARRIteelneAAARegcerqLC 378
Cdd:COG4581 201 VPLEFHYLV-TPRLFPLFRVNPELlrPPSRHEVIEELDRGGllPAIVFIFSRRGCDEAAQQL------LSAR------LT 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 379 ASEEVQRLA----------SSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVI 448
Cdd:COG4581 268 TKEERAEIReaidefaedfSVLFGKTLSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVV 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 74025910 449 VKGTTFFkNGNRD-DLPLSEIAQMSGRAGRPGLDTHGVALVLTTDD 493
Cdd:COG4581 348 FTKLSKF-DGERHrPLTAREFHQIAGRAGRRGIDTEGHVVVLAPEH 392
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
82-536 |
4.70e-42 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 166.29 E-value: 4.70e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 82 NVVVAAPTGSGKTALLEAAMLRlfkdrltlntvgsdaalppnaddevDAASGNKeyansptnrkAVYICPMKALAFEKYT 161
Cdd:PRK02362 41 NLLAAIPTASGKTLIAELAMLK-------------------------AIARGGK----------ALYIVPLRALASEKFE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 162 QWrERFPAL--SVVMETGDQEamRTVDAIMDEvfqtDIIITTPERWDGITRrwkEGVVWnlVASVALLMLDEVHTV-SEE 238
Cdd:PRK02362 86 EF-ERFEELgvRVGISTGDYD--SRDEWLGDN----DIIVATSEKVDSLLR---NGAPW--LDDITCVVVDEVHLIdSAN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 239 RGAALEAVVSRMKAIKLSMttrgpQVcrtrfVAISGTLPNIEDFAEWLQvppAGVFsfTSADRPLPL------------- 305
Cdd:PRK02362 154 RGPTLEVTLAKLRRLNPDL-----QV-----VALSATIGNADELADWLD---AELV--DSEWRPIDLregvfyggaihfd 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 306 -TLRVVSYPSTssnpfafDRFLTLKLFGLIrrysEGRPTLVFCASRGETMNSARRITEELNEAAAREGCERQLCASEEVQ 384
Cdd:PRK02362 219 dSQREVEVPSK-------DDTLNLVLDTLE----EGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAELAELAEEIR 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 385 RLASSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPAHLVIVkgttffKNGNRDD-- 462
Cdd:PRK02362 288 EVSDTETSKDLADCVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVII------RDYRRYDgg 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 463 -----LPLSEIAQMSGRAGRPGLDTHGVALVLTTDDKA-------YLYKPLQHgdtcttVESRLhqnmiehvNAEVALRT 530
Cdd:PRK02362 362 agmqpIPVLEYHQMAGRAGRPGLDPYGEAVLLAKSYDEldelferYIWADPED------VRSKL--------ATEPALRT 427
|
....*.
gi 74025910 531 iHNLSL 536
Cdd:PRK02362 428 -HVLST 432
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
60-296 |
7.85e-42 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 152.03 E-value: 7.85e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 60 FPHtnFTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDrltlntvgsdaalPPNAddevdaasgnkeyan 139
Cdd:cd18021 1 FKF--FNPIQTQVFNSLYNTDDNVFVGAPTGSGKTVCAELALLRHWRQ-------------NPKG--------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 140 sptnrKAVYICPMKALAFEKYTQWRERF---PALSVVMETGDQeamrTVDAIMDEvfQTDIIITTPERWDGITRRWKEGv 216
Cdd:cd18021 51 -----RAVYIAPMQELVDARYKDWRAKFgplLGKKVVKLTGET----STDLKLLA--KSDVILATPEQWDVLSRRWKQR- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 217 vwNLVASVALLMLDEVHTVSEERGAALEAVVSRMKAIklsmttRGPQVCRTRFVAISGTLPNIEDFAEWLQVPPAGVFSF 296
Cdd:cd18021 119 --KNVQSVELFIADELHLIGGENGPVYEVVVSRMRYI------SSQLEKPIRIVGLSSSLANARDVGEWLGASKSTIFNF 190
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
65-288 |
1.93e-40 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 147.79 E-value: 1.93e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 65 FTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLfkdrltLNTVGSdaalppnaddevdaasgnkeyansptnr 144
Cdd:cd17921 2 LNPIQREALRALYLSGDSVLVSAPTSSGKTLIAELAILRA------LATSGG---------------------------- 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 145 KAVYICPMKALAFEKYTQWRERF--PALSVVMETGDQeamrTVDAIMDEvfQTDIIITTPERWDGITRRWKEgvvwNLVA 222
Cdd:cd17921 48 KAVYIAPTRALVNQKEADLRERFgpLGKNVGLLTGDP----SVNKLLLA--EADILVATPEKLDLLLRNGGE----RLIQ 117
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74025910 223 SVALLMLDEVHTVS-EERGAALEAVVSRMKaiklsmtTRGPQVcrtRFVAISGTLPNIEDFAEWLQV 288
Cdd:cd17921 118 DVRLVVVDEAHLIGdGERGVVLELLLSRLL-------RINKNA---RFVGLSATLPNAEDLAEWLGV 174
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
63-296 |
2.02e-34 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 131.72 E-value: 2.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 63 TNFTRVQERVIPAIIQNDFNVVVAAPTGSGKT--ALLeaAMLR-LFKDRltlntvgsdaalppNADDEVDAAsgnkeyan 139
Cdd:cd18019 16 KSLNRIQSKLFPAAFETDENLLLCAPTGAGKTnvALL--TILReIGKHR--------------NPDGTINLD-------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 140 sptNRKAVYICPMKALAFEKYTQWRERFPALSVVME--TGDQEAMRtvdaimDEVFQTDIIITTPERWDGITRRWKEGVV 217
Cdd:cd18019 72 ---AFKIVYIAPMKALVQEMVGNFSKRLAPYGITVAelTGDQQLTK------EQISETQIIVTTPEKWDIITRKSGDRTY 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 218 WNLvasVALLMLDEVHTVSEERGAALEAVVSRmkAIKLSMTTRGPqvcrTRFVAISGTLPNIEDFAEWLQVPPA-GVFSF 296
Cdd:cd18019 143 TQL---VRLIIIDEIHLLHDDRGPVLESIVAR--TIRQIEQTQEY----VRLVGLSATLPNYEDVATFLRVDPKkGLFYF 213
|
|
| Sec63 |
pfam02889 |
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of ... |
637-952 |
1.15e-32 |
|
Sec63 Brl domain; This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons.
Pssm-ID: 460740 Cd Length: 307 Bit Score: 129.63 E-value: 1.15e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 637 STRVGRAMARRYILFKTVETLNRELlhrfshqsgrqgapqimgaamaeeegqiqqktGESFTLHQVLRVFCHSSEFDGLR 716
Cdd:pfam02889 1 PTDLGRIASHYYISYETIETFNQSL--------------------------------KPNTTLADLLRILSSASEFEQIP 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 717 LRQGDKKHLNELNKVIRFPLncgmrggREVREDWH-KVYVLIQAHLDRVAVSDFSLRNDCVRLWTVAPRVARFVVDYATT 795
Cdd:pfam02889 49 VRQEEKKELKKLLEKVPIPV-------KGDIEDPHaKVNILLQAYISRLKLPGFALVSDMNYILQNAGRILRALFEILLS 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 796 HPCFSLIQQSSLLCRCIEQGTWWDGLIIKQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNPPFGTDLQEKCH 875
Cdd:pfam02889 122 KGWLSAALTALDLCKMIEQRMWDSDSPLRQFPGIPPELIKKLEKKGVESVRDILELDDAEELGELIRNPKMGKDIAQFVN 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 876 SRPMYNLALE---HVTEAGTVRVVVsykagvsTRRDPPLEQCHMI-----LLVGDLELDRTHLLRQID-CRTANRRPLVF 946
Cdd:pfam02889 202 RFPKIEIEAEvqpITRSVLRVEVTI-------TPDFPWDKRVHGKsegfwLVVGDSDGNEILHIERFTlTKRTLAGEHKL 274
|
....*.
gi 74025910 947 TFQVSP 952
Cdd:pfam02889 275 EFTVPP 280
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
67-296 |
8.99e-32 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 123.69 E-value: 8.99e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 67 RVQERVIPAIIQNDFNVVVAAPTGSGKTallEAAMLRLfkdrltLNTVGSDaaLPPNADDEVDaasgnkeyansptNRKA 146
Cdd:cd18020 4 RIQSLVFPVAYKTNENMLICAPTGAGKT---NIAMLTI------LHEIRQH--VNQGGVIKKD-------------DFKI 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 147 VYICPMKALAFEKYTQWRERFPALSVVME--TGDQEAMRTvdaimdEVFQTDIIITTPERWDGITRrwKEGVVWNLVASV 224
Cdd:cd18020 60 VYIAPMKALAAEMVEKFSKRLAPLGIKVKelTGDMQLTKK------EIAETQIIVTTPEKWDVVTR--KSSGDVALSQLV 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74025910 225 ALLMLDEVHTVSEERGAALEAVVSRmkaiklsmTTRgpQVCRT----RFVAISGTLPNIEDFAEWLQVPP-AGVFSF 296
Cdd:cd18020 132 RLLIIDEVHLLHDDRGPVIESLVAR--------TLR--QVESTqsmiRIVGLSATLPNYLDVADFLRVNPyKGLFFF 198
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
68-286 |
6.74e-29 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 114.35 E-value: 6.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 68 VQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRlfkdrltlntvgsdAALppnaddevdaasgnkeyanspTNRKAV 147
Cdd:cd18028 5 PQAEAVRAGLLKGENLLISIPTASGKTLIAEMAMVN--------------TLL---------------------EGGKAL 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 148 YICPMKALAFEKYTQWRERF-PALSVVMETGDQEamRTVDAIMDevfqTDIIITTPERWDGITRrwkegVVWNLVASVAL 226
Cdd:cd18028 50 YLVPLRALASEKYEEFKKLEeIGLKVGISTGDYD--EDDEWLGD----YDIIVATYEKFDSLLR-----HSPSWLRDVGV 118
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74025910 227 LMLDEVHTVS-EERGAALEAVVSRMKAIKLsmttrgpqvcRTRFVAISGTLPNIEDFAEWL 286
Cdd:cd18028 119 VVVDEIHLISdEERGPTLESIVARLRRLNP----------NTQIIGLSATIGNPDELAEWL 169
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
66-282 |
7.14e-25 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 102.32 E-value: 7.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 66 TRVQERVIPAIIQNDfNVVVAAPTGSGKTALLEAAMLRLFKDRLTlntvgsdaalppnaddevdaasgnkeyansptNRK 145
Cdd:pfam00270 1 TPIQAEAIPAILEGR-DVLVQAPTGSGKTLAFLLPALEALDKLDN--------------------------------GPQ 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 146 AVYICPMKALAFEKYTQWRERF--PALSVVMETGDQEamrtVDAIMDEVFQTDIIITTPERWDGITRRWKegvvwnLVAS 223
Cdd:pfam00270 48 ALVLAPTRELAEQIYEELKKLGkgLGLKVASLLGGDS----RKEQLEKLKGPDILVGTPGRLLDLLQERK------LLKN 117
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74025910 224 VALLMLDEVHTVSEE-RGAALEAVVSRMKAIKlsmttrgpqvcrtRFVAISGTLP-NIEDF 282
Cdd:pfam00270 118 LKLLVLDEAHRLLDMgFGPDLEEILRRLPKKR-------------QILLLSATLPrNLEDL 165
|
|
| SEC63 |
smart00611 |
Domain of unknown function in Sec63p, Brr2p and other proteins; |
635-953 |
3.50e-23 |
|
Domain of unknown function in Sec63p, Brr2p and other proteins;
Pssm-ID: 214744 Cd Length: 312 Bit Score: 101.95 E-value: 3.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 635 VESTRVGRAMARRYILFKTVETLNrELLHRFshqsgrqgapqimgaaMAEEEgqiqqktgesftlhqVLRVFCHSSEFDG 714
Cdd:smart00611 2 IWPTDLGRIASYYYISYTTIRTFN-ELLKPK----------------MTTKD---------------LLRILSMSSEFDQ 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 715 LRLRQGDKKHLNELNKVIRFPLNCgmrggrEVREDWH-KVYVLIQAHLDRVAVSDFSLRNDCVRLWTVAPRVARFVVDYA 793
Cdd:smart00611 50 IPVRHEEDLLLEELAEKLPIRLEN------PSLDDPHvKANLLLQAHLSRLKLPSFALESDTVYVLQNAGRLLQAMVDIA 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 794 TT----HPCFSLIQqsslLCRCIEQGTWWDGLIIKQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNPPFGTD 869
Cdd:smart00611 124 LErgwlSTALNALN----LSQMIIQALWPTDSPLLQLPHLPEEILKRLEKKKVLSLEDLLELEDEERGELLGLLDAEGER 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 870 LQEKCHSRPMYNL--ALEHVTEAgTVRVVVSYKAGVsTRRDPPLEQC-HMILLVGDLELD-----RTHLLRQIDCRTANR 941
Cdd:smart00611 200 VYKVLSRLPKLNIeiSLEPITRT-VLGVEVTLTVDL-TWDDEIHGKQeGWWLVIGDSDGNellhiERFSLNKKNVSEEVK 277
|
330
....*....|..
gi 74025910 942 rpLVFTFQVSPG 953
Cdd:smart00611 278 --LDFTAPATEG 287
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
58-286 |
3.75e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.94 E-value: 3.75e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 58 SYFPHTNFTRVQERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRLtlntvgsdaalppnaddevdaasgnkey 137
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGK---------------------------- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 138 ansptNRKAVYICPMKALAFEKYTQWRERFP--ALSVVMETGDQEAMRTVDAIMDEVfqTDIIITTPERWDGITRRWKEG 215
Cdd:smart00487 54 -----GGRVLVLVPTRELAEQWAEELKKLGPslGLKVVGLYGGDSKREQLRKLESGK--TDILVTTPGRLLDLLENDKLS 126
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74025910 216 VVWnlvasVALLMLDEVHTVSE-ERGAALEAVVSRMKAIKlsmttrgpqvcrtRFVAISGTLPNIEDFAEWL 286
Cdd:smart00487 127 LSN-----VDLVILDEAHRLLDgGFGDQLEKLLKLLPKNV-------------QLLLLSATPPEEIENLLEL 180
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
145-525 |
1.18e-16 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 85.71 E-value: 1.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 145 KAVYICPMKALAFEKYTQWRERF-PALSVVMETG-----DQEAMRTVDAimdevfqtDIIITTPERWDGITRRWKE---- 214
Cdd:COG1202 256 KMLFLVPLVALANQKYEDFKDRYgDGLDVSIRVGasrirDDGTRFDPNA--------DIIVGTYEGIDHALRTGRDlgdi 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 215 GVVwnlvasvallMLDEVHTVSE-ERGAALEAVVSRMKAIklsmtTRGPQvcrtrFVAISGTLPNIEDFAEWLQvppAGV 293
Cdd:COG1202 328 GTV----------VIDEVHMLEDpERGHRLDGLIARLKYY-----CPGAQ-----WIYLSATVGNPEELAKKLG---AKL 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 294 FSFtsADRPLPLtlrvvsypstssnpfafDRFLTL-----KLfGLIRR---------YSEGRptlvfcasRGETM---NS 356
Cdd:COG1202 385 VEY--EERPVPL-----------------ERHLTFadgreKI-RIINKlvkrefdtkSSKGY--------RGQTIiftNS 436
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 357 ARRiTEELNEAaaregcerqlcaseevqrlassandkqlrtmllLGI--AYHHAAMTANDRTLVERMFMGHYVSVICTTT 434
Cdd:COG1202 437 RRR-CHEIARA---------------------------------LGYkaAPYHAGLDYGERKKVERRFADQELAAVVTTA 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 435 TLALGVNLPAHLVIvkgttfFKN---GNrDDLPLSEIAQMSGRAGRPGLDTHGVALVLTTDDKAYlykplqHGDTCTTVE 511
Cdd:COG1202 483 ALAAGVDFPASQVI------FDSlamGI-EWLSVQEFHQMLGRAGRPDYHDRGKVYLLVEPGKSY------HRSMEMTED 549
|
410
....*....|....*..
gi 74025910 512 S---RLHQNMIEHVNAE 525
Cdd:COG1202 550 EvafKLLKGEMEDVAVE 566
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
82-302 |
6.87e-14 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 71.86 E-value: 6.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 82 NVVVAAPTGSGKTALLEAAMLRLFKDRltlntvgsdaalppnaddevdaasgnkeyansptNRKAVYICPMKALAFEKYT 161
Cdd:cd18026 35 NLVYSLPTSGGKTLVAEILMLKRLLER----------------------------------RKKALFVLPYVSIVQEKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 162 QWRERFPALSVVMET--GDQEAMRTVDaimdeVFQTDIIITTPERWDGITRRW-KEGVVWNLvasvALLMLDEVHTVSEE 238
Cdd:cd18026 81 ALSPLFEELGFRVEGyaGNKGRSPPKR-----RKSLSVAVCTIEKANSLVNSLiEEGRLDEL----GLVVVDELHMLGDG 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74025910 239 -RGAALEAVVSRMkaikLSMTTRGPQVcrtrfVAISGTLPNIEDFAEWLQvppAGVfsFTSADRP 302
Cdd:cd18026 152 hRGALLELLLTKL----LYAAQKNIQI-----VGMSATLPNLEELASWLR---AEL--YTTNFRP 202
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
63-440 |
1.37e-13 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 75.91 E-value: 1.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 63 TNFTRVQERVIPAIIQNDfNVVVAAPTGSGKT--ALLeAAMLRLFKdrltlntvgsdAALPPNADDEVdaasgnkeyans 140
Cdd:COG1201 23 GAPTPPQREAWPAIAAGE-STLLIAPTGSGKTlaAFL-PALDELAR-----------RPRPGELPDGL------------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 141 ptnrKAVYICPMKALAF-----------EKYTQWRERFPALSVVMETGD---QE--AMRTvdaimdevfQT-DIIITTPE 203
Cdd:COG1201 78 ----RVLYISPLKALANdiernlrapleEIGEAAGLPLPEIRVGVRTGDtpaSErqRQRR---------RPpHILITTPE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 204 rwdgitrrwkegvvwnlvaSVALLM----------------LDEVHTVSE-ERGAALEAVVSRMKAIklsmTTRGPQVcr 266
Cdd:COG1201 145 -------------------SLALLLtspdarellrgvrtviVDEIHALAGsKRGVHLALSLERLRAL----APRPLQR-- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 267 trfVAISGTLPNIEDFAEWLqVPPAGVFSFT--SADRPLPLTLRVVSYPSTSSNPFAFDRFLTL----KLFGLIRRYseg 340
Cdd:COG1201 200 ---IGLSATVGPLEEVARFL-VGYEDPRPVTivDAGAGKKPDLEVLVPVEDLIERFPWAGHLWPhlypRVLDLIEAH--- 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 341 RPTLVFCASRGetmnSARRITEELNEAAARegcerqlcaseevqrlassandkqlrtmLLLGIAYHHAAMTANDRTLVER 420
Cdd:COG1201 273 RTTLVFTNTRS----QAERLFQRLNELNPE----------------------------DALPIAAHHGSLSREQRLEVEE 320
|
410 420
....*....|....*....|
gi 74025910 421 MFMGHYVSVICTTTTLALGV 440
Cdd:COG1201 321 ALKAGELRAVVATSSLELGI 340
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
80-286 |
8.66e-13 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 67.61 E-value: 8.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 80 DFNVVVAAPTGSGKTallEAAMLRLFkDRLtlntvgsdaalppnaddevdaasgnkeYANSPTNRKAVYICPMKALAFEk 159
Cdd:cd17922 1 GRNVLIAAPTGSGKT---EAAFLPAL-SSL---------------------------ADEPEKGVQVLYISPLKALIND- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 160 ytQWR-------ERFPALSVVMETGD------QEAMRTVDaimdevfqtDIIITTPERWDGITRRWKegvVWNLVASVAL 226
Cdd:cd17922 49 --QERrleepldEIDLEIPVAVRHGDtsqsekAKQLKNPP---------GILITTPESLELLLVNKK---LRELFAGLRY 114
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74025910 227 LMLDEVHTV-SEERGAALEAVVSRMKAIklsmTTRGPQVcrtrfVAISGTLPNIEDFAEWL 286
Cdd:cd17922 115 VVVDEIHALlGSKRGVQLELLLERLRKL----TGRPLRR-----IGLSATLGNLEEAAAFL 166
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
401-479 |
1.92e-10 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 58.38 E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 401 LGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLP-AHLVIVKGTtffkngnrdDLPLSEIAQMSGRAGRPG 479
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYIQRIGRAGRAG 82
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
85-486 |
1.98e-09 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 62.63 E-value: 1.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 85 VAAPTGSGKT-ALLEAAMLRLFKDRltlntvgsdaalppnaddevdaASGNKEYANSPTNRkAVYICPMKALA------- 156
Cdd:PRK09751 1 VIAPTGSGKTlAAFLYALDRLFREG----------------------GEDTREAHKRKTSR-ILYISPIKALGtdvqrnl 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 157 ---FEKYTQWRERFPALSVVMETGdqeaMRTVDAIMDEVFQ-----TDIIITTPER-WDGITRRWKEGvvwnlVASVALL 227
Cdd:PRK09751 58 qipLKGIADERRRRGETEVNLRVG----IRTGDTPAQERSKltrnpPDILITTPESlYLMLTSRARET-----LRGVETV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 228 MLDEVHTVS-EERGAALEAVVSRMKAIKLSMTTRgpqvcrtrfVAISGTLPNIEDFAEWL-QVPPAGVFSFTSADRPlpl 305
Cdd:PRK09751 129 IIDEVHAVAgSKRGAHLALSLERLDALLHTSAQR---------IGLSATVRSASDVAAFLgGDRPVTVVNPPAMRHP--- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 306 TLRVV-------SYPSTSSNPFAFDR------FLTLKLFGLIRRYSEGRPTLVFCASRGetmnSARRITEELNEA-AARE 371
Cdd:PRK09751 197 QIRIVvpvanmdDVSSVASGTGEDSHagregsIWPYIETGILDEVLRHRSTIVFTNSRG----LAEKLTARLNELyAARL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 372 GCERQLCASEEVQRLASSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLPA-HLVIVK 450
Cdd:PRK09751 273 QRSPSIAVDAAHFESTSGATSNRVQSSDVFIARSHHGSVSKEQRAITEQALKSGELRCVVATSSLELGIDMGAvDLVIQV 352
|
410 420 430
....*....|....*....|....*....|....*.
gi 74025910 451 GTtffkngnrddlPLSeIAQMSGRAGRPGLDTHGVA 486
Cdd:PRK09751 353 AT-----------PLS-VASGLQRIGRAGHQVGGVS 376
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
77-284 |
6.71e-09 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 56.82 E-value: 6.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 77 IQNDFNVVVAAPTGSGKTallEAAMLRLFkdrltlntvgsDAALppnaddevdaasgnkeyanSPTNRKAVYICPMKALA 156
Cdd:cd17923 12 ARAGRSVVVTTGTASGKS---LCYQLPIL-----------EALL-------------------RDPGSRALYLYPTKALA 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 157 ---FEKYTQWRERF-PALSVVMETGDqEAMRTVDAIMDEvfQTDIIITTP-----------ERWDGITRRWKegvvwnlv 221
Cdd:cd17923 59 qdqLRSLRELLEQLgLGIRVATYDGD-TPREERRAIIRN--PPRILLTNPdmlhyallphhDRWARFLRNLR-------- 127
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74025910 222 asvaLLMLDEVHTVSEERGAALEAVVSRMKAIkLSMTTRGPQvcrtrFVAISGTLPNIEDFAE 284
Cdd:cd17923 128 ----YVVLDEAHTYRGVFGSHVALLLRRLRRL-CRRYGADPQ-----FILTSATIGNPAEHAR 180
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
305-480 |
2.09e-07 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 51.44 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 305 LTLRVVSYPSTSsnpfafDRFLTLKLfglIRRYSEGRPTLVFCASRGEtmnsarriteelneaaaregCERqlcASEEVQ 384
Cdd:cd18794 4 LFYSVRPKDKKD------EKLDLLKR---IKVEHLGGSGIIYCLSRKE--------------------CEQ---VAARLQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 385 RLASSAndkqlrtmlllgiAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLP-----AHLvivkgttffkngn 459
Cdd:cd18794 52 SKGISA-------------AAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPdvrfvIHY------------- 105
|
170 180
....*....|....*....|...
gi 74025910 460 rdDLPLS--EIAQMSGRAGRPGL 480
Cdd:cd18794 106 --SLPKSmeSYYQESGRAGRDGL 126
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
76-287 |
3.36e-07 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 51.99 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 76 IIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRltlntvgsdaalppnaDDEVdaasgnkeyansptnrkAVYICPMKAL 155
Cdd:cd18025 12 IVDRRESALIVAPTSSGKTFISYYCMEKVLRES----------------DDGV-----------------VVYVAPTKAL 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 156 ----AFEKYTQWRERFPALSVVMEtgdqeAMRTVDAIMDEVFQTDIIITTPERWDGI-----TRRWKEGVVWnlvasval 226
Cdd:cd18025 59 vnqvVAEVYARFSKKYPPSGKSLW-----GVFTRDYRHNNPMNCQVLITVPECLEILllsphNASWVPRIKY-------- 125
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74025910 227 LMLDEVHTVSEERGAALEAvvsrmkaiKLSMTTRGPqvcrtrFVAISGTLPNIEDFAEWLQ 287
Cdd:cd18025 126 VIFDEIHSIGQSEDGAVWE--------QLLLLIPCP------FLALSATIGNPQKFHEWLQ 172
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
388-479 |
7.94e-07 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 49.13 E-value: 7.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 388 SSANDKQLRTMLLLGIAYHHAAMTANDRTLVERMFMGHYVSVICTTTTLALGVNLP-AHLVIvkgttFFkngnrdDLP-- 464
Cdd:pfam00271 26 KTLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVI-----NY------DLPwn 94
|
90
....*....|....*
gi 74025910 465 LSEIAQMSGRAGRPG 479
Cdd:pfam00271 95 PASYIQRIGRAGRAG 109
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
69-286 |
2.26e-06 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 50.13 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 69 QERVIpAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKDRltlntvgsdaalppnaddevdaasgnkeyansptnRKAVY 148
Cdd:cd18024 37 QKTAI-ACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDK-----------------------------------QRVIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 149 ICPMKALAFEKYTQWRERFPalSVVMETGDQEAMRTVDAImdeVFQTDIIITTPERWDGITRRwkegvvwnlvasVALLM 228
Cdd:cd18024 81 TSPIKALSNQKYRELQEEFG--DVGLMTGDVTINPNASCL---VMTTEILRSMLYRGSEIMRE------------VAWVI 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 74025910 229 LDEVHTVSE-ERGAALEAVVsrmkaIKLSMTTRgpqvcrtrFVAISGTLPNIEDFAEWL 286
Cdd:cd18024 144 FDEIHYMRDkERGVVWEETI-----ILLPDKVR--------YVFLSATIPNARQFAEWI 189
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
279-487 |
1.38e-05 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 49.37 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 279 IEDFAEWLQVPPAGVFSfTSADRPlPLTLRVVsyPSTSSNPFAFdrfltlkLFGLIRRYsEGRPTLVFCASRgetmNSAR 358
Cdd:COG0514 181 RADIAEQLGLEDPRVFV-GSFDRP-NLRLEVV--PKPPDDKLAQ-------LLDFLKEH-PGGSGIVYCLSR----KKVE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 359 RITEELNEAaaregcerqlcaseevqrlassandkqlrtmlllGI---AYHhAAMTANDRTLVERMFMGHYVSVICTTTT 435
Cdd:COG0514 245 ELAEWLREA----------------------------------GIraaAYH-AGLDAEEREANQDRFLRDEVDVIVATIA 289
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 74025910 436 LALGVNLP-----AHLvivkgttffkngnrdDLPLSEIA--QMSGRAGRPGLDTHGVAL 487
Cdd:COG0514 290 FGMGIDKPdvrfvIHY---------------DLPKSIEAyyQEIGRAGRDGLPAEALLL 333
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
63-95 |
1.83e-05 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 47.05 E-value: 1.83e-05
10 20 30
....*....|....*....|....*....|...
gi 74025910 63 TNFTRVQERVIPAIIQNDfNVVVAAPTGSGKTA 95
Cdd:cd00268 11 EKPTPIQAQAIPLILSGR-DVIGQAQTGSGKTL 42
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
63-231 |
7.24e-05 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 45.26 E-value: 7.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 63 TNFTRVQERVIPAIIQNDfNVVVAAPTGSGKTA-----LLEaaMLRLFKDRLTLNTVGsdaalppnaddevdaasgnkey 137
Cdd:cd17960 11 TSMTPVQAATIPLFLSNK-DVVVEAVTGSGKTLaflipVLE--ILLKRKANLKKGQVG---------------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 138 ansptnrkAVYICPMKALAfekyTQWRE--------RFPALSVVMETGDQEAMRTVDAIMDEVFqtDIIITTPERWDGIT 209
Cdd:cd17960 66 --------ALIISPTRELA----TQIYEvlqsflehHLPKLKCQLLIGGTNVEEDVKKFKRNGP--NILVGTPGRLEELL 131
|
170 180
....*....|....*....|..
gi 74025910 210 RRwkeGVVWNLVASVALLMLDE 231
Cdd:cd17960 132 SR---KADKVKVKSLEVLVLDE 150
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
70-233 |
7.80e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 44.59 E-value: 7.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 70 ERVIPAIIQNDFNVVVAAPTGSGKTALLEAAMLRLFKdrltlntvgsdaalppnaddevdaasgnkeyanSPTNRKAVYI 149
Cdd:pfam04851 13 ENLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFK---------------------------------KGPIKKVLFL 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 150 CPMKALafekYTQWRERFpaLSVVMETGDQEAMRTVDAIMDEVFQTDIIITTPERWDGITRRWKEGVVWNlvASVALLMl 229
Cdd:pfam04851 60 VPRKDL----LEQALEEF--KKFLPNYVEIGEIISGDKKDESVDDNKIVVTTIQSLYKALELASLELLPD--FFDVIII- 130
|
....
gi 74025910 230 DEVH 233
Cdd:pfam04851 131 DEAH 134
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
136-286 |
1.90e-04 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 43.79 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 136 EYANSPTNR---KAVYICPMKALAFEKYTQWRERFPALSVVmeTGDQEAMRTVDAImdeVFQTDIIITTPERWDGITRrw 212
Cdd:cd18027 41 EYAIALAQKhmtRTIYTSPIKALSNQKFRDFKNTFGDVGLI--TGDVQLNPEASCL---IMTTEILRSMLYNGSDVIR-- 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74025910 213 kegvvwnlvaSVALLMLDEVHTVSE-ERGAALEAVVsrmkaIKLsmttrgPQvcRTRFVAISGTLPNIEDFAEWL 286
Cdd:cd18027 114 ----------DLEWVIFDEVHYINDaERGVVWEEVL-----IML------PD--HVSIILLSATVPNTVEFADWI 165
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
62-95 |
2.58e-04 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 45.14 E-value: 2.58e-04
10 20 30
....*....|....*....|....*....|....
gi 74025910 62 HTNFTRVQERVIPAIIQNDfNVVVAAPTGSGKTA 95
Cdd:COG0513 22 YTTPTPIQAQAIPLILAGR-DVLGQAQTGTGKTA 54
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
55-94 |
3.93e-04 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 43.34 E-value: 3.93e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 74025910 55 PLASYFPHTNFTRVQERVIPAIIQNDfNVVVAAPTGSGKT 94
Cdd:cd17949 4 HLKSKMGIEKPTAIQKLAIPVLLQGR-DVLVRSQTGSGKT 42
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
821-878 |
1.11e-03 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 43.09 E-value: 1.11e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74025910 821 LIIKQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEALCGKNppfGTDLQEKC---HSRP 878
Cdd:PRK01810 179 LPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGIN---GVRLQRRAngiDDRP 236
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
56-237 |
1.14e-03 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 41.75 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 56 LASYFPHTNFTRVQERVIPAIIQNDfNVVVAAPTGSGKTALLE-AAMLRlfkDRLTLntVGSdaalPPNA--DDEVDAAS 132
Cdd:cd17920 4 LKEVFGYDEFRPGQLEAINAVLAGR-DVLVVMPTGGGKSLCYQlPALLL---DGVTL--VVS----PLISlmQDQVDRLQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 133 GNkeyansptNRKAVYICPmkalafekytqwrerfpalsvvmETGDQEAMRTVDAIMDEvfQTDIIITTPER--WDGITR 210
Cdd:cd17920 74 QL--------GIRAAALNS-----------------------TLSPEEKREVLLRIKNG--QYKLLYVTPERllSPDFLE 120
|
170 180
....*....|....*....|....*..
gi 74025910 211 RWKEgvvWNLVASVALLMLDEVHTVSE 237
Cdd:cd17920 121 LLQR---LPERKRLALIVVDEAHCVSQ 144
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
64-204 |
1.46e-03 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 41.80 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 64 NFTRVQERVIPAIIQNDFNVVVAAPTGSGKTAlleAAMLRLFKDRLtlntvgsdaalppnaddevdaaSGNKEYANSPTn 143
Cdd:cd17964 16 TMTPVQQKTLKPILSTGDDVLARAKTGTGKTL---AFLLPAIQSLL----------------------NTKPAGRRSGV- 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74025910 144 rKAVYICPMKALA------FEKYTQWRERFPALSVVMETGDQEAMRTvdaimdevFQT---DIIITTPER 204
Cdd:cd17964 70 -SALIISPTRELAlqiaaeAKKLLQGLRKLRVQSAVGGTSRRAELNR--------LRRgrpDILVATPGR 130
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
825-861 |
1.71e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 37.85 E-value: 1.71e-03
10 20 30
....*....|....*....|....*....|....*..
gi 74025910 825 QIEGIGENMAKALHEGGIKNFSDVLQANPRKLEALCG 861
Cdd:pfam14520 6 SISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPG 42
|
|
| H3TH |
COG3743 |
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain ... |
824-859 |
2.01e-03 |
|
Predicted 5' DNA nuclease, flap endonuclease-1-like, helix-3-turn-helix (H3TH) domain [Replication, recombination and repair];
Pssm-ID: 442957 [Multi-domain] Cd Length: 92 Bit Score: 38.76 E-value: 2.01e-03
10 20 30
....*....|....*....|....*....|....*.
gi 74025910 824 KQIEGIGENMAKALHEGGIKNFSDVLQANPRKLEAL 859
Cdd:COG3743 26 KKIKGIGPKIEKKLNELGIFTFAQIAAWTPEDIAWV 61
|
|
| |
