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The query sequence YP_003770343.1 may be preliminary or obsolete. For more information, check Entrez.
Conserved domains on  [gi|300790052|ref|YP_003770343.1|]
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fatty-acyl-CoA synthase [Amycolatopsis mediterranei U32]

Protein Classification

fatty acyl-AMP ligase( domain architecture ID 11482892)

fatty acyl-AMP ligase (FAAL) belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK07768 PRK07768
long-chain-fatty-acid--CoA ligase; Validated
1-577 0e+00

long-chain-fatty-acid--CoA ligase; Validated


:

Pssm-ID: 236091 [Multi-domain]  Cd Length: 545  Bit Score: 882.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   1 MSRFVDTLVATAtkRGQQRGMVTGEPKEPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAG 80
Cdd:PRK07768   1 MSRFTEKMYANA--RTSPRGMVTGEPDAPVRHTWGEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  81 GSVTMLHQPTPRTDLAEWAEDTVRVLGMIGSDqdalggpgglaprpgsgagprnvTVLLGEPFDQLAPVLEQKGIGFQLI 160
Cdd:PRK07768  79 ASLTMLHQPTPRTDLAVWAEDTLRVIGMIGAK-----------------------AVVVGEPFLAAAPVLEEKGIRVLTV 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 161 TELAAAEPlPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLT 240
Cdd:PRK07768 136 ADLLAADP-IDPVETGEDDLALMQLTSGSTGSPKAVQITHGNLYANAEAMFVAAEFDVETDVMVSWLPLFHDMGMVGFLT 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 241 VPMTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQ 320
Cdd:PRK07768 215 VPMYFGAELVKVTPMDFLRDPLLWAELISKYRGTMTAAPNFAYALLARRLRRQAKPGAFDLSSLRFALNGAEPIDPADVE 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 321 TFVDAGARFKMPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALEAENRAVPVPEGdprrgtdGVRSFALLGRPLD 400
Cdd:PRK07768 295 DLLDAGARFGLRPEAILPAYGMAEATLAVSFSPCGAGLVVDEVDADLLAALRRAVPATKG-------NTRRLATLGPPLP 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLVD-GQIVICGRRKDVIIMGGRNL 479
Cdd:PRK07768 368 GLEVRVVDEDGQVLPPRGVGVIELRGESVTPGYLTMDGFIPAQDADGWLDTGDLGYLTEeGEVVVCGRVKDVIIMAGRNI 447
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 480 YPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLP 559
Cdd:PRK07768 448 YPTDIERAAARVEGVRPGNAVAVRLDAGHSREGFAVAVESNAFEDPAEVRRIRHQVAHEVVAEVGVRPRNVVVLGPGSIP 527
                        570
                 ....*....|....*...
gi 300790052 560 KTPSGKVKRAATAQQFAD 577
Cdd:PRK07768 528 KTPSGKLRRANAAELVTP 545
 
Name Accession Description Interval E-value
PRK07768 PRK07768
long-chain-fatty-acid--CoA ligase; Validated
1-577 0e+00

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236091 [Multi-domain]  Cd Length: 545  Bit Score: 882.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   1 MSRFVDTLVATAtkRGQQRGMVTGEPKEPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAG 80
Cdd:PRK07768   1 MSRFTEKMYANA--RTSPRGMVTGEPDAPVRHTWGEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  81 GSVTMLHQPTPRTDLAEWAEDTVRVLGMIGSDqdalggpgglaprpgsgagprnvTVLLGEPFDQLAPVLEQKGIGFQLI 160
Cdd:PRK07768  79 ASLTMLHQPTPRTDLAVWAEDTLRVIGMIGAK-----------------------AVVVGEPFLAAAPVLEEKGIRVLTV 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 161 TELAAAEPlPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLT 240
Cdd:PRK07768 136 ADLLAADP-IDPVETGEDDLALMQLTSGSTGSPKAVQITHGNLYANAEAMFVAAEFDVETDVMVSWLPLFHDMGMVGFLT 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 241 VPMTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQ 320
Cdd:PRK07768 215 VPMYFGAELVKVTPMDFLRDPLLWAELISKYRGTMTAAPNFAYALLARRLRRQAKPGAFDLSSLRFALNGAEPIDPADVE 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 321 TFVDAGARFKMPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALEAENRAVPVPEGdprrgtdGVRSFALLGRPLD 400
Cdd:PRK07768 295 DLLDAGARFGLRPEAILPAYGMAEATLAVSFSPCGAGLVVDEVDADLLAALRRAVPATKG-------NTRRLATLGPPLP 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLVD-GQIVICGRRKDVIIMGGRNL 479
Cdd:PRK07768 368 GLEVRVVDEDGQVLPPRGVGVIELRGESVTPGYLTMDGFIPAQDADGWLDTGDLGYLTEeGEVVVCGRVKDVIIMAGRNI 447
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 480 YPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLP 559
Cdd:PRK07768 448 YPTDIERAAARVEGVRPGNAVAVRLDAGHSREGFAVAVESNAFEDPAEVRRIRHQVAHEVVAEVGVRPRNVVVLGPGSIP 527
                        570
                 ....*....|....*...
gi 300790052 560 KTPSGKVKRAATAQQFAD 577
Cdd:PRK07768 528 KTPSGKLRRANAAELVTP 545
FAAL cd05931
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...
20-577 4.36e-174

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.


Pssm-ID: 341254 [Multi-domain]  Cd Length: 547  Bit Score: 504.47  E-value: 4.36e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  20 GMVTGEPKEPVRRTWAEVHEEARRIAGGLVAGGfERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRtdlaEWA 99
Cdd:cd05931   13 TFLDDEGGREETLTYAELDRRARAIAARLQAVG-KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLPPPTPG----RHA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 100 EDTVRVLGmigsdqDAlgGPGGLAPRPGSGAGPRNVTVLLgepfdqlapvlEQKGIGFQLITELAAAEPLPDVVVT--DE 177
Cdd:cd05931   88 ERLAAILA------DA--GPRVVLTTAAALAAVRAFAASR-----------PAAGTPRLLVVDLLPDTSAADWPPPspDP 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 178 GDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEF 257
Cdd:cd05931  149 DDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYGLDPG-DVVVSWLPLYHDMGLIGGLLTPLYSGGPSVLMSPAAF 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 258 LSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDaYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMPAECVF 337
Cdd:cd05931  228 LRRPLRWLRLISRYRATISAAPNFAYDLCVRRVRDEDLEG-LDLSSWRVALNGAEPVRPATLRRFAEAFAPFGFRPEAFR 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 338 PAYGMAEATLAVSFAPLFTGLTLDVVEADALEaeNRAVPVPEGDPrrgtdGVRSFALLGRPLDGLEAEIVDDAGKR-VDE 416
Cdd:cd05931  307 PSYGLAEATLFVSGGPPGTGPVVLRVDRDALA--GRAVAVAADDP-----AARELVSCGRPLPDQEVRIVDPETGReLPD 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 417 REVGEIRLRGEAVTPGYLTMD-------GPLATQDEDGWLNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIERAAT 489
Cdd:cd05931  380 GEVGEIWVRGPSVASGYWGRPeataetfGALAATDEGGWLRTGDLGFLHDGELYITGRLKDLIIVRGRNHYPQDIEATAE 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 490 SVEGV-RAGNAVAVRLDAGSrRERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKR 568
Cdd:cd05931  460 EAHPAlRPGCVAAFSVPDDG-EERLVVVAEVERGADPADLAAIAAAIRAAVAREHGVAPADVVLVRPGSIPRTSSGKIQR 538

                 ....*....
gi 300790052 569 AATAQQFAD 577
Cdd:cd05931  539 RACRAAYLD 547
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
4-578 1.07e-84

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 271.30  E-value: 1.07e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   4 FVDTLVATATKRGQQRGMVTGEpkepVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSV 83
Cdd:COG0318    1 LADLLRRAAARHPDRPALVFGG----RRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  84 TMLHQPTPRTDLAEWAEDtvrvlgmigsdqdalggpgglaprpgsgAGPRnvtvllgepfdqlapvleqkgigfqlitel 163
Cdd:COG0318   77 VPLNPRLTAEELAYILED----------------------------SGAR------------------------------ 98
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 164 aaaeplpdVVVTdegdtALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPM 243
Cdd:COG0318   99 --------ALVT-----ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPG-DVVLVALPLFHVFGLTVGLLAPL 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 244 TFGVELV---KITPVEFLsgpliwpELITKYHGT-TTAAPNFAYaivgrRMARVDEDDAYDLSKLRIALNGAEPIDETAV 319
Cdd:COG0318  165 LAGATLVllpRFDPERVL-------ELIERERVTvLFGVPTMLA-----RLLRHPEFARYDLSSLRLVVSGGAPLPPELL 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 320 QTFVDagaRFKMPaecVFPAYGMAEATLAVSFAPlftgltldvveadaleaenravpVPEGDPRRGTdgvrsfalLGRPL 399
Cdd:COG0318  233 ERFEE---RFGVR---IVEGYGLTETSPVVTVNP-----------------------EDPGERRPGS--------VGRPL 275
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 400 DGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLV-DGQIVICGRRKDVIIMGGRN 478
Cdd:COG0318  276 PGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAFRDGWLRTGDLGRLDeDGYLYIVGRKKDMIISGGEN 355
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 479 LYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAvdMRPYAVVVLPAgsL 558
Cdd:COG0318  356 VYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVLRPGAELDAEE---LRAFLRERLARY--KVPRRVEFVDE--L 428
                        570       580
                 ....*....|....*....|
gi 300790052 559 PKTPSGKVKRAATAQQFADR 578
Cdd:COG0318  429 PRTASGKIDRRALRERYAAG 448
FadD32_Coryne NF040633
FadD32-like long-chain-fatty-acid--AMP ligase; Members of this family are found in the genus ...
178-577 3.54e-62

FadD32-like long-chain-fatty-acid--AMP ligase; Members of this family are found in the genus Corynebacterium, are most similar to the key mycolic acid biosynthesis protein FadD32 of any fatty acid--AMP ligase in Mycobacterium tuberculosis, and are likewise encoded next to Pks13. However, as the mycolic acids produced in Corynebacterium and in Mycobacterium differ substantially, it is not clear that assigning the same name in Corynebacterium is appropriate.


Pssm-ID: 468603 [Multi-domain]  Cd Length: 613  Bit Score: 216.06  E-value: 3.54e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 178 GDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDvMVSWLPTFHDMGMV--GFLTVpmtFGVELVKITPV 255
Cdd:NF040633 201 DDTAFLQYTSGSTRTPAGVVLTNRSIVTNVLQIFTAAQLKTPLR-LVSWLPLHHDMGIIlaAFVTI---LGLEFELMSPR 276
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 256 EFLSGPLIWPELITKYHG---TTTAAPNFAYAIVGrRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMP 332
Cdd:NF040633 277 DFIQQPKRWVDQLSRREDdvnVYTVVPNFALELAA-RYANPEEGEDLDLSAVDGIIIGSEPVTEKAVDAFLDAFGPYGLR 355
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 333 AECVFPAYGMAEATLAVSFA-----PLFTgltldVVEADALeAENRAVPVPEGDPrrgtDGVrSFALLGRPLDGLEAEIV 407
Cdd:NF040633 356 RTALRPSYGLAEASLLVTTPqteerPLFT-----YFDREAL-AEGRAVEVAEDSE----NAV-PFASNGQVVRPQVLAIV 424
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDA-GKRVDEREVGEIRLRGEAVTPGYL------------TMDGPLATQD------EDGWLNTGDLGYLVDGQIVICGRR 468
Cdd:NF040633 425 DPEtGQELPDGTVGEIWVHGDNMAAGYLdreeetaetfrnTLGERLAENSraegapEDNWMATGDLGVIVDGELYITGRL 504
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 469 KDVIIMGGRNLYPTDIERAA-TSVEGVRAGnAVAVRLDAGSRRERFAVVLESKL----AGDAEAEknlmKQVSARVRDAV 543
Cdd:NF040633 505 KDLIVIAGRNHYPQDIEATVqEASDHIRPD-SVAAFAVPGDDVEKLVILAERDDeadeSGDAEAI----EAIRAAVTSAH 579
                        410       420       430
                 ....*....|....*....|....*....|....
gi 300790052 544 DMRPYAVVVLPAGSLPKTPSGKVKRAATAQQFAD 577
Cdd:NF040633 580 GVVPADIRIVAPGEIARSSSGKIARRVNAKAYLE 613
AMP-binding pfam00501
AMP-binding enzyme;
28-475 8.85e-56

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 193.68  E-value: 8.85e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   28 EPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAA--APVLIAptVQAVWLAGG-SVTMLHQPTPRtDLAEWAEDT-V 103
Cdd:pfam00501  18 EGRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPnsPEWVVA--FLACLKAGAvYVPLNPRLPAE-ELAYILEDSgA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  104 RVLgmIGSDQDALGGpggLAPRPGSGAGPRNVTVLLGEPFDQLAPVLEqkgigfqliTELAAAEPLPDVVVTDEGDTALL 183
Cdd:pfam00501  95 KVL--ITDDALKLEE---LLEALGKLEVVKLVLVLDRDPVLKEEPLPE---------EAKPADVPPPPPPPPDPDDLAYI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  184 QLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDV---DVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEFLSg 260
Cdd:pfam00501 161 IYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLgpdDRVLSTLPLFHDFGLSLGLLGPLLAGATVVLPPGFPALD- 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  261 PLIWPELITKYHGTTTAAPNFAYaivgRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARfkmpaeCVFPAY 340
Cdd:pfam00501 240 PAALLELIERYKVTVLYGVPTLL----NMLLEAGAPKRALLSSLRLVLSGGAPLPPELARRFRELFGG------ALVNGY 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  341 GMAEATLAVSFAPlftgltldvveadaleaenravPVPEGDPRRGTdgvrsfalLGRPLDGLEAEIVDDA-GKRVDEREV 419
Cdd:pfam00501 310 GLTETTGVVTTPL----------------------PLDEDLRSLGS--------VGRPLPGTEVKIVDDEtGEPVPPGEP 359
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  420 GEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYLV-DGQIVICGRRKDVIIMG 475
Cdd:pfam00501 360 GELCVRGPGVMKGYL--NDPELTAeafDEDGWYRTGDLGRRDeDGYLEIVGRKKDQIKLG 417
FAAL_FadD32 NF038339
long-chain-fatty-acid--AMP ligase FAAL32/FadD32; FadD32, also called FAAL32, is a marker ...
165-577 3.22e-52

long-chain-fatty-acid--AMP ligase FAAL32/FadD32; FadD32, also called FAAL32, is a marker enzyme for the biosynthesis of the type of mycolic acids, the very large "eumycolic acids", found in Mycobacterium.


Pssm-ID: 468483 [Multi-domain]  Cd Length: 625  Bit Score: 189.16  E-value: 3.22e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 165 AAEPLPDVV-------VTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMvg 237
Cdd:NF038339 157 AVDAVPDSVgstwvrpDADLDDIAYLQYTSGSTRVPAGVEITHRAVATNVLQMVDAIELDEN-SRGVTWLPLFHDMGL-- 233
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 238 fLTV--PMTFGVELVKITPVEFLSGPLIW-PELITK--YHGTTTAAPNFAYAIVGRRmARVDEDDAYDLSKLRIALNGAE 312
Cdd:NF038339 234 -LTVilPALGGKYITIMSPAAFVRRPGRWiRELAAVsdGAGTFAAAPNFAFEHAAAR-GLPKEGEPLDLSNVIGLINGSE 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 313 PIDETAVQTFVDAGARFKMPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALEAeNRAVPVPEGDPrrgtDGVRSF 392
Cdd:NF038339 312 PVTTSSMRKFNEAFAPYGLPKTAIKPSYGMAEATLFVSSTPREDEAKVIYVDREELNA-GRIVEVDPDAP----NAVAQV 386
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 393 AlLGRPLDGLEAEIVD-DAGKRVDEREVGEIRLRGEAVTPGYL--------TMDGPLATQDEDG-----------WLNTG 452
Cdd:NF038339 387 S-CGYVARSQWAVIVDpETGTELPDGQVGEIWLHGNNIGTGYWgrpeeteeTFHNKLKSRLEEGshaegapedanWMRTG 465
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 453 DLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIER--------------AATSV------EGVRAGNAVAVRLDAGSRRER 512
Cdd:NF038339 466 DYGVYYDGELYITGRVKDLVIVDGRNHYPQDLEYsaqeaskalrpgfvAAFSVpanqlpAEVFENSHSGLKYDADDSSEQ 545
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052 513 FAVVLEsKLAGDAEAEKnlmKQVSARVRDAVDMR----PYAVVVLPAGSLPKTPSGKVKRAATAQQFAD 577
Cdd:NF038339 546 LVIVAE-RAPGAGKADP---QPIADAVRAAIAVRhgvtVRDVLLVPAGSIPRTSSGKIARRACKAAYID 610
FAAL_FadD21 NF038337
fatty-acid--AMP ligase FAAL21/FadD21;
170-575 1.09e-49

fatty-acid--AMP ligase FAAL21/FadD21;


Pssm-ID: 439631 [Multi-domain]  Cd Length: 579  Bit Score: 181.23  E-value: 1.09e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVerAEFDFDVD-------VMVSWLPTFHDMGMVGFLTVP 242
Cdd:NF038337 155 PSIRISDAPSIAYLQYTSGSTRLPAGVMVSHRNLQVNFQQLM--AAYFPDTNgvaprdtTIVSWLPFYHDMGLVLGVIAP 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 243 MTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDAyDLSKLRIALNGAEPIDETAVQTF 322
Cdd:NF038337 233 ILGGYRSELTSPVAFLQRPARWIHAMANGSPVFSAAPNFAFELAVRKTTDADLAGL-DLGNVIGIVSGAERIHPATLDRF 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 323 VDAGARFKMPAECVFPAYGMAEATLAVsfaplftgltldvveadALEAENRAVPVPEGDPRRGTDGV--RSFALLGRPLD 400
Cdd:NF038337 312 CKRFAPYNFREDMMQPSYGLAEATVYV-----------------ASRAEGGAPEVVHFEPEKLSEGSaqRCEARTGSPLL 374
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEA------EIVD-DAGKRVDEREVGEIRLRGEAVTPGYL------------TMDGPLATQDEDGWLNTGDLGYLVDGQ 461
Cdd:NF038337 375 SYGTptsptvRIVDpDTCIECPAGTVGEIWVHGDNVAEGYWqkpeetrrtfggVLANPSPGTPEGPWLRTGDLGFISEDE 454
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 462 IVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGnAVAVRLDagsRRERFAVVLESKLAGDAEAEKN-----LMKQVS 536
Cdd:NF038337 455 MFIVGRMKDLLIVYGRNHYPEDIESTVQEITGGRVA-AISVPVD---ETEKLVTIIELKKRGDSDEEAMrkldaVKNNVT 530
                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 300790052 537 ARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKRAATAQQF 575
Cdd:NF038337 531 AAISRSHGLNVADLVLVPPGSIPTTTSGKIRRAACVEQY 569
menE TIGR01923
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ...
33-570 2.55e-31

O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 162605 [Multi-domain]  Cd Length: 436  Bit Score: 126.41  E-value: 2.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmigSD 112
Cdd:TIGR01923   1 TWQDLDCEAAHLAKALKAQGIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLED---------LD 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  113 QDALggpggLAPRPgsgagprnvtvllgepfdqlapvLEQKGIGFQLITELAAAEPLPDVVVTDEG--DTALLQLTSGST 190
Cdd:TIGR01923  72 VQLL-----LTDSL-----------------------LEEKDFQADSLDRIEAAGRYETSLSASFNmdQIATLMFTSGTT 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  191 ADPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHDMGmVGFLTVPMTFGVELVKITPVEFLSgpliwpELITk 270
Cdd:TIGR01923 124 GKPKAVPHTFRNHYASAVGSKENLGFT-EDDNWLLSLPLYHISG-LSILFRWLIEGATLRIVDKFNQLL------EMIA- 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  271 yHGTTTAApnfayAIVGRRMARVDEDDAYDLSkLRIALNGAEPIDETAVQTFVDAGarfkMPaecVFPAYGMAEATLAVS 350
Cdd:TIGR01923 195 -NERVTHI-----SLVPTQLNRLLDEGGHNEN-LRKILLGGSAIPAPLIEEAQQYG----LP---IYLSYGMTETCSQVT 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  351 FAPlftgltldvveadaleaenravpvPEGDPRRGTdgvrsfalLGRPLDGLEAEIvddagKRVDEREVGEIRLRGEAVT 430
Cdd:TIGR01923 261 TAT------------------------PEMLHARPD--------VGRPLAGREIKI-----KVDNKEGHGEIMVKGANLM 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  431 PGYLTmDGPL-ATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGS 508
Cdd:TIGR01923 304 KGYLY-QGELtPAFEQQGWFNTGDIGELdGEGFLYVLGRRDDLIISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWG 382
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300790052  509 RRERFAVVLESKLAgDAEAEKNLMKQVsARVRdavdmRPYAVVVLPagSLPKTPSGKVKRAA 570
Cdd:TIGR01923 383 QVPVAYIVSESDIS-QAKLIAYLTEKL-AKYK-----VPIAFEKLD--ELPYNASGKILRNQ 435
 
Name Accession Description Interval E-value
PRK07768 PRK07768
long-chain-fatty-acid--CoA ligase; Validated
1-577 0e+00

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236091 [Multi-domain]  Cd Length: 545  Bit Score: 882.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   1 MSRFVDTLVATAtkRGQQRGMVTGEPKEPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAG 80
Cdd:PRK07768   1 MSRFTEKMYANA--RTSPRGMVTGEPDAPVRHTWGEVHERARRIAGGLAAAGVGPGDAVAVLAGAPVEIAPTAQGLWMRG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  81 GSVTMLHQPTPRTDLAEWAEDTVRVLGMIGSDqdalggpgglaprpgsgagprnvTVLLGEPFDQLAPVLEQKGIGFQLI 160
Cdd:PRK07768  79 ASLTMLHQPTPRTDLAVWAEDTLRVIGMIGAK-----------------------AVVVGEPFLAAAPVLEEKGIRVLTV 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 161 TELAAAEPlPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLT 240
Cdd:PRK07768 136 ADLLAADP-IDPVETGEDDLALMQLTSGSTGSPKAVQITHGNLYANAEAMFVAAEFDVETDVMVSWLPLFHDMGMVGFLT 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 241 VPMTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQ 320
Cdd:PRK07768 215 VPMYFGAELVKVTPMDFLRDPLLWAELISKYRGTMTAAPNFAYALLARRLRRQAKPGAFDLSSLRFALNGAEPIDPADVE 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 321 TFVDAGARFKMPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALEAENRAVPVPEGdprrgtdGVRSFALLGRPLD 400
Cdd:PRK07768 295 DLLDAGARFGLRPEAILPAYGMAEATLAVSFSPCGAGLVVDEVDADLLAALRRAVPATKG-------NTRRLATLGPPLP 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLVD-GQIVICGRRKDVIIMGGRNL 479
Cdd:PRK07768 368 GLEVRVVDEDGQVLPPRGVGVIELRGESVTPGYLTMDGFIPAQDADGWLDTGDLGYLTEeGEVVVCGRVKDVIIMAGRNI 447
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 480 YPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLP 559
Cdd:PRK07768 448 YPTDIERAAARVEGVRPGNAVAVRLDAGHSREGFAVAVESNAFEDPAEVRRIRHQVAHEVVAEVGVRPRNVVVLGPGSIP 527
                        570
                 ....*....|....*...
gi 300790052 560 KTPSGKVKRAATAQQFAD 577
Cdd:PRK07768 528 KTPSGKLRRANAAELVTP 545
FAAL cd05931
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...
20-577 4.36e-174

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.


Pssm-ID: 341254 [Multi-domain]  Cd Length: 547  Bit Score: 504.47  E-value: 4.36e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  20 GMVTGEPKEPVRRTWAEVHEEARRIAGGLVAGGfERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRtdlaEWA 99
Cdd:cd05931   13 TFLDDEGGREETLTYAELDRRARAIAARLQAVG-KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLPPPTPG----RHA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 100 EDTVRVLGmigsdqDAlgGPGGLAPRPGSGAGPRNVTVLLgepfdqlapvlEQKGIGFQLITELAAAEPLPDVVVT--DE 177
Cdd:cd05931   88 ERLAAILA------DA--GPRVVLTTAAALAAVRAFAASR-----------PAAGTPRLLVVDLLPDTSAADWPPPspDP 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 178 GDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEF 257
Cdd:cd05931  149 DDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYGLDPG-DVVVSWLPLYHDMGLIGGLLTPLYSGGPSVLMSPAAF 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 258 LSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDaYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMPAECVF 337
Cdd:cd05931  228 LRRPLRWLRLISRYRATISAAPNFAYDLCVRRVRDEDLEG-LDLSSWRVALNGAEPVRPATLRRFAEAFAPFGFRPEAFR 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 338 PAYGMAEATLAVSFAPLFTGLTLDVVEADALEaeNRAVPVPEGDPrrgtdGVRSFALLGRPLDGLEAEIVDDAGKR-VDE 416
Cdd:cd05931  307 PSYGLAEATLFVSGGPPGTGPVVLRVDRDALA--GRAVAVAADDP-----AARELVSCGRPLPDQEVRIVDPETGReLPD 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 417 REVGEIRLRGEAVTPGYLTMD-------GPLATQDEDGWLNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIERAAT 489
Cdd:cd05931  380 GEVGEIWVRGPSVASGYWGRPeataetfGALAATDEGGWLRTGDLGFLHDGELYITGRLKDLIIVRGRNHYPQDIEATAE 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 490 SVEGV-RAGNAVAVRLDAGSrRERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKR 568
Cdd:cd05931  460 EAHPAlRPGCVAAFSVPDDG-EERLVVVAEVERGADPADLAAIAAAIRAAVAREHGVAPADVVLVRPGSIPRTSSGKIQR 538

                 ....*....
gi 300790052 569 AATAQQFAD 577
Cdd:cd05931  539 RACRAAYLD 547
PRK05851 PRK05851
long-chain-fatty acid--ACP ligase MbtM;
30-574 8.67e-104

long-chain-fatty acid--ACP ligase MbtM;


Pssm-ID: 180289 [Multi-domain]  Cd Length: 525  Bit Score: 323.26  E-value: 8.67e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  30 VRRTWAEVHEEARRIAGGLVAGGfeRGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDTVRVLGMI 109
Cdd:PRK05851  30 RRHPWPEVHGRAENVAARLLDRD--RPGAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGADDGRWADATLTRFAGI 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 GSDqdalggpgglaprpgsgagprnvTVL-LGEPFDQLAPVleQKGIGFQLITELAAAEPLPDVVVTDEGDTALLQLTSG 188
Cdd:PRK05851 108 GVR-----------------------TVLsHGSHLERLRAV--DSSVTVHDLATAAHTNRSASLTPPDSGGPAVLQGTAG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 189 STADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLTVPMTfGVELVKITPVEFLSGPLIWPELI 268
Cdd:PRK05851 163 STGTPRTAILSPGAVLSNLRGLNARVGLDAATDVGCSWLPLYHDMGLAFLLTAALA-GAPLWLAPTTAFSASPFRWLSWL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 269 TKYHGTTTAAPNFAYAIVGRRMARVDEddaYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMPAECVFPAYGMAEATLA 348
Cdd:PRK05851 242 SDSRATLTAAPNFAYNLIGKYARRVSD---VDLGALRVALNGGEPVDCDGFERFATAMAPFGFDAGAAAPSYGLAESTCA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 349 VSFAPLFTGLTLDVVEADAleaenravpvpegdprrgTDGVRSFALLGRPLDGLEAEIVDDAGKR-VDEREVGEIRLRGE 427
Cdd:PRK05851 319 VTVPVPGIGLRVDEVTTDD------------------GSGARRHAVLGNPIPGMEVRISPGDGAAgVAGREIGEIEIRGA 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 428 AVTPGYLTMDgPLatqDEDGWLNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAG 507
Cdd:PRK05851 381 SMMSGYLGQA-PI---DPDDWFPTGDLGYLVDGGLVVCGRAKELITVAGRNIFPTEIERVAAQVRGVREGAVVAVGTGEG 456
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300790052 508 SRRERFAVVLESKLAGDAEAEKNLMKQVSARvrdaVDMRPYAVVVLPAGSLPKTPSGKVKRAATAQQ 574
Cdd:PRK05851 457 SARPGLVIAAEFRGPDEAGARSEVVQRVASE----CGVVPSDVVFVAPGSLPRTSSGKLRRLAVKRS 519
PRK09192 PRK09192
fatty acyl-AMP ligase;
34-575 5.97e-100

fatty acyl-AMP ligase;


Pssm-ID: 236403 [Multi-domain]  Cd Length: 579  Bit Score: 315.02  E-value: 5.97e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  34 WAEVHEEARRIAGGLVAGGFERGTAVGvlaaapvLIAPT----VQAVW---LAGGSVTMLHQPTPRTDLAEWAEdtvRVL 106
Cdd:PRK09192  52 YQTLRARAEAGARRLLALGLKPGDRVA-------LIAETdgdfVEAFFacqYAGLVPVPLPLPMGFGGRESYIA---QLR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 107 GMIGSDQ-DALGGPGGLAPRPGSGAGPRN-VTVLLGEPFDQLApvleqkgigfqlitelAAAEPLPDVvvtDEGDTALLQ 184
Cdd:PRK09192 122 GMLASAQpAAIITPDELLPWVNEATHGNPlLHVLSHAWFKALP----------------EADVALPRP---TPDDIAYLQ 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 185 LTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEFLSGPLIW 264
Cdd:PRK09192 183 YSSGSTRFPRGVIITHRALMANLRAISHDGLKVRPGDRCVSWLPFYHDMGLVGFLLTPVATQLSVDYLPTRDFARRPLQW 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 265 PELITKYHGTTTAAPNFAYAIVGRRMARVDEDDaYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMPAECVFPAYGMAE 344
Cdd:PRK09192 263 LDLISRNRGTISYSPPFGYELCARRVNSKDLAE-LDLSCWRVAGIGADMIRPDVLHQFAEAFAPAGFDDKAFMPSYGLAE 341
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 345 ATLAVSFAPLFTGLTLDVVEADALEAENRAVPvPEGDPRRgtdgVRSFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRL 424
Cdd:PRK09192 342 ATLAVSFSPLGSGIVVEEVDRDRLEYQGKAVA-PGAETRR----VRTFVNCGKALPGHEIEIRNEAGMPLPERVVGHICV 416
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 425 RGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRL 504
Cdd:PRK09192 417 RGPSLMSGYFRDEESQDVLAADGWLDTGDLGYLLDGYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELRSGDAAAFSI 496
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300790052 505 DAGSrRERFAVVLESKLaGDAEAEKNLMKQVSARVRDAVDMrPYAVVVLPAGSLPKTPSGKVKRAATAQQF 575
Cdd:PRK09192 497 AQEN-GEKIVLLVQCRI-SDEERRGQLIHALAALVRSEFGV-EAAVELVPPHSLPRTSSGKLSRAKAKKRY 564
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
4-578 1.07e-84

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 271.30  E-value: 1.07e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   4 FVDTLVATATKRGQQRGMVTGEpkepVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSV 83
Cdd:COG0318    1 LADLLRRAAARHPDRPALVFGG----RRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  84 TMLHQPTPRTDLAEWAEDtvrvlgmigsdqdalggpgglaprpgsgAGPRnvtvllgepfdqlapvleqkgigfqlitel 163
Cdd:COG0318   77 VPLNPRLTAEELAYILED----------------------------SGAR------------------------------ 98
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 164 aaaeplpdVVVTdegdtALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPM 243
Cdd:COG0318   99 --------ALVT-----ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPG-DVVLVALPLFHVFGLTVGLLAPL 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 244 TFGVELV---KITPVEFLsgpliwpELITKYHGT-TTAAPNFAYaivgrRMARVDEDDAYDLSKLRIALNGAEPIDETAV 319
Cdd:COG0318  165 LAGATLVllpRFDPERVL-------ELIERERVTvLFGVPTMLA-----RLLRHPEFARYDLSSLRLVVSGGAPLPPELL 232
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 320 QTFVDagaRFKMPaecVFPAYGMAEATLAVSFAPlftgltldvveadaleaenravpVPEGDPRRGTdgvrsfalLGRPL 399
Cdd:COG0318  233 ERFEE---RFGVR---IVEGYGLTETSPVVTVNP-----------------------EDPGERRPGS--------VGRPL 275
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 400 DGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLV-DGQIVICGRRKDVIIMGGRN 478
Cdd:COG0318  276 PGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEATAEAFRDGWLRTGDLGRLDeDGYLYIVGRKKDMIISGGEN 355
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 479 LYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAvdMRPYAVVVLPAgsL 558
Cdd:COG0318  356 VYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVLRPGAELDAEE---LRAFLRERLARY--KVPRRVEFVDE--L 428
                        570       580
                 ....*....|....*....|
gi 300790052 559 PKTPSGKVKRAATAQQFADR 578
Cdd:COG0318  429 PRTASGKIDRRALRERYAAG 448
A_NRPS_MycA_like cd05908
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ...
159-575 2.52e-81

The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341234 [Multi-domain]  Cd Length: 499  Bit Score: 263.97  E-value: 2.52e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 159 LITELAAAEPLPDVVvtdegdtALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGF 238
Cdd:cd05908   94 LITEEEVLCELADEL-------AFIQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTK-DRILSWMPLTHDMGLIAF 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 239 LTVPMTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDaYDLSKLRIALNGAEPIDETA 318
Cdd:cd05908  166 HLAPLIAGMNQYLMPTRLFIRRPILWLKKASEHKATIVSSPNFGYKYFLKTLKPEKAND-WDLSSIRMILNGAEPIDYEL 244
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 319 VQTFVDAGARFKMPAECVFPAYGMAEATLAVSFAPL---FTGLTLDvveadaLEAENRAVPVPEGDpRRGTDGVRsFALL 395
Cdd:cd05908  245 CHEFLDHMSKYGLKRNAILPVYGLAEASVGASLPKAqspFKTITLG------RRHVTHGEPEPEVD-KKDSECLT-FVEV 316
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYltMDGPLATQD---EDGWLNTGDLGYLVDGQIVICGRRKDVI 472
Cdd:cd05908  317 GKPIDETDIRICDEDNKILPDGYIGHIQIRGKNVTPGY--YNNPEATAKvftDDGWLKTGDLGFIRNGRLVITGREKDII 394
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 473 IMGGRNLYPTDIERAATSVEGVRAGNAVAVRL-DAGSRRER-FAVVLESKLAGD-AEAEKNLMKQVSARVRDAVDMrpya 549
Cdd:cd05908  395 FVNGQNVYPHDIERIAEELEGVELGRVVACGVnNSNTRNEEiFCFIEHRKSEDDfYPLGKKIKKHLNKRGGWQINE---- 470
                        410       420
                 ....*....|....*....|....*.
gi 300790052 550 vvVLPAGSLPKTPSGKVKRAATAQQF 575
Cdd:cd05908  471 --VLPIRRIPKTTSGKVKRYELAQRY 494
A_NRPS_TubE_like cd05906
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ...
8-575 3.84e-77

The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341232 [Multi-domain]  Cd Length: 540  Bit Score: 254.13  E-value: 3.84e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   8 LVATATKRGQQRGMVT-GEPKEPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTML 86
Cdd:cd05906   15 LLLRAAERGPTKGITYiDADGSEEFQSYQDLLEDARRLAAGLRQLGLRPGDSVILQFDDNEDFIPAFWACVLAGFVPAPL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  87 hqPTPRTDlaEWAEDTVRVLgmigsdqdalggpgglaprpgsgagpRNVTVLLGEPF--------DQLAPVLEQKGI-GF 157
Cdd:cd05906   95 --TVPPTY--DEPNARLRKL--------------------------RHIWQLLGSPVvltdaelvAEFAGLETLSGLpGI 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 158 QLIT--ELAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGM 235
Cdd:cd05906  145 RVLSieELLDTAADHDLPQSRPDDLALLMLTSGSTGFPKAVPLTHRNILARSAGKIQHNGLTPQ-DVFLNWVPLDHVGGL 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 236 VGFLTVPMTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARvDEDDAYDLSKLRIALNGAEPID 315
Cdd:cd05906  224 VELHLRAVYLGCQQVHVPTEEILADPLRWLDLIDRYRVTITWAPNFAFALLNDLLEE-IEDGTWDLSSLRYLVNAGEAVV 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 316 ETAVQTFVDAGARFKMPAECVFPAYGMAEaTLAvsfaplftGLTLDVVeadaleaenravpvpegDPRRGTDGVRSFALL 395
Cdd:cd05906  303 AKTIRRLLRLLEPYGLPPDAIRPAFGMTE-TCS--------GVIYSRS-----------------FPTYDHSQALEFVSL 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQD---EDGWLNTGDLGYLVDGQIVICGRRKDVI 472
Cdd:cd05906  357 GRPIPGVSMRIVDDEGQLLPEGEVGRLQVRGPVVTKGYY--NNPEANAEaftEDGWFRTGDLGFLDNGNLTITGRTKDTI 434
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 473 IMGGRNLYPTDIERAATSVEGVRAG--NAVAVRlDAGSRRERFAVVLESKLAGDAEAEKnLMKQVSARVRDAVDMRPYAV 550
Cdd:cd05906  435 IVNGVNYYSHEIEAAVEEVPGVEPSftAAFAVR-DPGAETEELAIFFVPEYDLQDALSE-TLRAIRSVVSREVGVSPAYL 512
                        570       580
                 ....*....|....*....|....*
gi 300790052 551 VVLPAGSLPKTPSGKVKRAATAQQF 575
Cdd:cd05906  513 IPLPKEEIPKTSLGKIQRSKLKAAF 537
PRK05691 PRK05691
peptide synthase; Validated
176-577 3.35e-66

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 235.06  E-value: 3.35e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  176 DEGDTALLQLTSGSTADPKAVRITYGNLYSNvkAMVERAEFDFDV---DVMVSWLPTFHDMGMVGFLTVPMTFGVELVKI 252
Cdd:PRK05691  164 QPDDIAFLQYTSGSTALPKGVQVSHGNLVAN--EQLIRHGFGIDLnpdDVIVSWLPLYHDMGLIGGLLQPIFSGVPCVLM 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  253 TPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGrrmARVDED--DAYDLSKLRIALNGAEPIDETAVQTFVDAGARFK 330
Cdd:PRK05691  242 SPAYFLERPLRWLEAISEYGGTISGGPDFAYRLCS---ERVSESalERLDLSRWRVAYSGSEPIRQDSLERFAEKFAACG 318
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  331 MPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALeAENRAVPvPEGDPRRGTdgvrsfallGRPLDGLEAEIVDDA 410
Cdd:PRK05691  319 FDPDSFFASYGLAEATLFVSGGRRGQGIPALELDAEAL-ARNRAEP-GTGSVLMSC---------GRSQPGHAVLIVDPQ 387
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  411 -GKRVDEREVGEIRLRGEAVTPGYLTmdGPLATQ----DEDG--WLNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYPTD 483
Cdd:PRK05691  388 sLEVLGDNRVGEIWASGPSIAHGYWR--NPEASAktfvEHDGrtWLRTGDLGFLRDGELFVTGRLKDMLIVRGHNLYPQD 465
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  484 IERAATS-VEGVRAGN--AVAVRLDAgsrRERFAVVLE-SKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLP 559
Cdd:PRK05691  466 IEKTVEReVEVVRKGRvaAFAVNHQG---EEGIGIAAEiSRSVQKILPPQALIKSIRQAVAEACQEAPSVVLLLNPGALP 542
                         410
                  ....*....|....*...
gi 300790052  560 KTPSGKVKRAATAQQFAD 577
Cdd:PRK05691  543 KTSSGKLQRSACRLRLAD 560
FadD32_Coryne NF040633
FadD32-like long-chain-fatty-acid--AMP ligase; Members of this family are found in the genus ...
178-577 3.54e-62

FadD32-like long-chain-fatty-acid--AMP ligase; Members of this family are found in the genus Corynebacterium, are most similar to the key mycolic acid biosynthesis protein FadD32 of any fatty acid--AMP ligase in Mycobacterium tuberculosis, and are likewise encoded next to Pks13. However, as the mycolic acids produced in Corynebacterium and in Mycobacterium differ substantially, it is not clear that assigning the same name in Corynebacterium is appropriate.


Pssm-ID: 468603 [Multi-domain]  Cd Length: 613  Bit Score: 216.06  E-value: 3.54e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 178 GDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDvMVSWLPTFHDMGMV--GFLTVpmtFGVELVKITPV 255
Cdd:NF040633 201 DDTAFLQYTSGSTRTPAGVVLTNRSIVTNVLQIFTAAQLKTPLR-LVSWLPLHHDMGIIlaAFVTI---LGLEFELMSPR 276
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 256 EFLSGPLIWPELITKYHG---TTTAAPNFAYAIVGrRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMP 332
Cdd:NF040633 277 DFIQQPKRWVDQLSRREDdvnVYTVVPNFALELAA-RYANPEEGEDLDLSAVDGIIIGSEPVTEKAVDAFLDAFGPYGLR 355
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 333 AECVFPAYGMAEATLAVSFA-----PLFTgltldVVEADALeAENRAVPVPEGDPrrgtDGVrSFALLGRPLDGLEAEIV 407
Cdd:NF040633 356 RTALRPSYGLAEASLLVTTPqteerPLFT-----YFDREAL-AEGRAVEVAEDSE----NAV-PFASNGQVVRPQVLAIV 424
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDA-GKRVDEREVGEIRLRGEAVTPGYL------------TMDGPLATQD------EDGWLNTGDLGYLVDGQIVICGRR 468
Cdd:NF040633 425 DPEtGQELPDGTVGEIWVHGDNMAAGYLdreeetaetfrnTLGERLAENSraegapEDNWMATGDLGVIVDGELYITGRL 504
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 469 KDVIIMGGRNLYPTDIERAA-TSVEGVRAGnAVAVRLDAGSRRERFAVVLESKL----AGDAEAEknlmKQVSARVRDAV 543
Cdd:NF040633 505 KDLIVIAGRNHYPQDIEATVqEASDHIRPD-SVAAFAVPGDDVEKLVILAERDDeadeSGDAEAI----EAIRAAVTSAH 579
                        410       420       430
                 ....*....|....*....|....*....|....
gi 300790052 544 DMRPYAVVVLPAGSLPKTPSGKVKRAATAQQFAD 577
Cdd:NF040633 580 GVVPADIRIVAPGEIARSSSGKIARRVNAKAYLE 613
AFD_class_I cd04433
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...
179-567 1.29e-61

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341228 [Multi-domain]  Cd Length: 336  Bit Score: 207.14  E-value: 1.29e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHdMGMVGFLTVPMTFGVELVKITPVEfl 258
Cdd:cd04433    1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEG-DVFLSTLPLFH-IGGLFGLLGALLAGGTVVLLPKFD-- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 sgPLIWPELITKYHGTTTAAPNFAYaivgRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVdagARFKMPaecVFP 338
Cdd:cd04433   77 --PEAALELIEREKVTILLGVPTLL----ARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFE---EAPGIK---LVN 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 339 AYGMAEATLAVSFAPlftgltldvveadaleaenravpVPEGDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDERE 418
Cdd:cd04433  145 GYGLTETGGTVATGP-----------------------PDDDARKPGS--------VGRPVPGVEVRIVDPDGGELPPGE 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 419 VGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAg 497
Cdd:cd04433  194 IGELVVRGPSVMKGYWNNPEATAAVDEDGWYRTGDLGRLdEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAE- 272
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300790052 498 nAVAVRLDAGSRRERFAVVLESKLAGDAEAEknlmkQVSARVRDavDMRPYAV--VVLPAGSLPKTPSGKVK 567
Cdd:cd04433  273 -AAVVGVPDPEWGERVVAVVVLRPGADLDAE-----ELRAHVRE--RLAPYKVprRVVFVDALPRTASGKID 336
PRK07769 PRK07769
long-chain-fatty-acid--CoA ligase; Validated
173-577 1.31e-61

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 181109 [Multi-domain]  Cd Length: 631  Bit Score: 214.98  E-value: 1.31e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 173 VVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLtVPMTFGVELVKI 252
Cdd:PRK07769 175 PEANEDTIAYLQYTSGSTRIPAGVQITHLNLPTNVLQVIDALEGQEG-DRGVSWLPFFHDMGLITVL-LPALLGHYITFM 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 253 TPVEFLSGPLIW-PELITKYH---GTTTAAPNFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGAR 328
Cdd:PRK07769 253 SPAAFVRRPGRWiRELARKPGgtgGTFSAAPNFAFEHAAARGLPKDGEPPLDLSNVKGLLNGSEPVSPASMRKFNEAFAP 332
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 329 FKMPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALeAENRAVPVPEGDPRR------GTDGVRSFALlgrpldgl 402
Cdd:PRK07769 333 YGLPPTAIKPSYGMAEATLFVSTTPMDEEPTVIYVDRDEL-NAGRFVEVPADAPNAvaqvsaGKVGVSEWAV-------- 403
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 403 eaeIVD-DAGKRVDEREVGEIRLRGEAVTPGYL------------TMDGPLA------TQDEDGWLNTGDLGYLVDGQIV 463
Cdd:PRK07769 404 ---IVDpETASELPDGQIGEIWLHGNNIGTGYWgkpeetaatfqnILKSRLSeshaegAPDDALWVRTGDYGVYFDGELY 480
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 464 ICGRRKDVIIMGGRNLYPTDIERAA-TSVEGVRAGNAVA-------------------VRLDAGSRRERFAVVLEsKLAG 523
Cdd:PRK07769 481 ITGRVKDLVIIDGRNHYPQDLEYTAqEATKALRTGYVAAfsvpanqlpqvvfddshagLKFDPEDTSEQLVIVAE-RAPG 559
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 300790052 524 DAEAEknlMKQVSARVRDAVDMR----PYAVVVLPAGSLPKTPSGKVKRAATAQQFAD 577
Cdd:PRK07769 560 AHKLD---PQPIADDIRAAIAVRhgvtVRDVLLVPAGSIPRTSSGKIARRACRAAYLD 614
PRK05850 PRK05850
acyl-CoA synthetase; Validated
170-575 5.89e-61

acyl-CoA synthetase; Validated


Pssm-ID: 235624 [Multi-domain]  Cd Length: 578  Bit Score: 211.72  E-value: 5.89e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDV-----MVSWLPTFHDMGMVGFLTVPMT 244
Cdd:PRK05850 152 SDARPRDLPSTAYLQYTSGSTRTPAGVMVSHRNVIANFEQLMSDYFGDTGGVPppdttVVSWLPFYHDMGLVLGVCAPIL 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 245 FGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMArvDEDDA-YDLSKLRIALNGAEPIDETAVQTFV 323
Cdd:PRK05850 232 GGCPAVLTSPVAFLQRPARWMQLLASNPHAFSAAPNFAFELAVRKTS--DDDMAgLDLGGVLGIISGSERVHPATLKRFA 309
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 324 DAGARFKMPAECVFPAYGMAEATLAVSFAPlfTGLTLDVVEADALE-AENRAVPVPEGDprrGTDGVRsfalLGRPLDGL 402
Cdd:PRK05850 310 DRFAPFNLRETAIRPSYGLAEATVYVATRE--PGQPPESVRFDYEKlSAGHAKRCETGG---GTPLVS----YGSPRSPT 380
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 403 eAEIVD-DAGKRVDEREVGEIRLRGEAVTPGYL------------TMDGPLATQDEDGWLNTGDLGYLVDGQIVICGRRK 469
Cdd:PRK05850 381 -VRIVDpDTCIECPAGTVGEIWVHGDNVAAGYWqkpeetertfgaTLVDPSPGTPEGPWLRTGDLGFISEGELFIVGRIK 459
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 470 DVIIMGGRNLYPTDIEraATsVEGVRAGNAVAVRLDAGSrRERFAVVLESKLAGDAEAE-----KNLMKQVSARVRDAVD 544
Cdd:PRK05850 460 DLLIVDGRNHYPDDIE--AT-IQEITGGRVAAISVPDDG-TEKLVAIIELKKRGDSDEEamdrlRTVKREVTSAISKSHG 535
                        410       420       430
                 ....*....|....*....|....*....|.
gi 300790052 545 MRPYAVVVLPAGSLPKTPSGKVKRAATAQQF 575
Cdd:PRK05850 536 LSVADLVLVAPGSIPITTSGKIRRAACVEQY 566
PRK12476 PRK12476
putative fatty-acid--CoA ligase; Provisional
176-577 3.54e-57

putative fatty-acid--CoA ligase; Provisional


Pssm-ID: 171527 [Multi-domain]  Cd Length: 612  Bit Score: 202.28  E-value: 3.54e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 176 DEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFdFDVDVM-VSWLPTFHDMG--MVGFltvPMTFGVELVKI 252
Cdd:PRK12476 191 DTDDVSHLQYTSGSTRPPVGVEITHRAVGTNLVQMILSIDL-LDRNTHgVSWLPLYHDMGlsMIGF---PAVYGGHSTLM 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 253 TPVEFLSGPLIWPELIT---KYHGTTTAAPNFAYAIVGRRmARVDEDDAYDLSKLrIALNGAEPIDETAVQTFVDAGARF 329
Cdd:PRK12476 267 SPTAFVRRPQRWIKALSegsRTGRVVTAAPNFAYEWAAQR-GLPAEGDDIDLSNV-VLIIGSEPVSIDAVTTFNKAFAPY 344
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 330 KMPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALEAeNRAVPVPEGDPRrgtdgVRSFALLGRPLDGLEAEIVD- 408
Cdd:PRK12476 345 GLPRTAFKPSYGIAEATLFVATIAPDAEPSVVYLDREQLGA-GRAVRVAADAPN-----AVAHVSCGQVARSQWAVIVDp 418
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 409 DAGKRVDEREVGEIRLRGEAVTPGY--------LTMDGPLATQDEDG-----------WLNTGDLGYLVDGQIVICGRRK 469
Cdd:PRK12476 419 DTGAELPDGEVGEIWLHGDNIGRGYwgrpeeteRTFGAKLQSRLAEGshadgaaddgtWLRTGDLGVYLDGELYITGRIA 498
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 470 DVIIMGGRNLYPTDIE-RAATSVEGVRAGNAVAVRLDaGSRRERFAVVLEsKLAGDAEAEKN-LMKQVSARVRDAVDMRP 547
Cdd:PRK12476 499 DLIVIDGRNHYPQDIEaTVAEASPMVRRGYVTAFTVP-AEDNERLVIVAE-RAAGTSRADPApAIDAIRAAVSRRHGLAV 576
                        410       420       430
                 ....*....|....*....|....*....|
gi 300790052 548 YAVVVLPAGSLPKTPSGKVKRAATAQQFAD 577
Cdd:PRK12476 577 ADVRLVPAGAIPRTTSGKLARRACRAQYLD 606
AMP-binding pfam00501
AMP-binding enzyme;
28-475 8.85e-56

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 193.68  E-value: 8.85e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   28 EPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAA--APVLIAptVQAVWLAGG-SVTMLHQPTPRtDLAEWAEDT-V 103
Cdd:pfam00501  18 EGRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPnsPEWVVA--FLACLKAGAvYVPLNPRLPAE-ELAYILEDSgA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  104 RVLgmIGSDQDALGGpggLAPRPGSGAGPRNVTVLLGEPFDQLAPVLEqkgigfqliTELAAAEPLPDVVVTDEGDTALL 183
Cdd:pfam00501  95 KVL--ITDDALKLEE---LLEALGKLEVVKLVLVLDRDPVLKEEPLPE---------EAKPADVPPPPPPPPDPDDLAYI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  184 QLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDV---DVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEFLSg 260
Cdd:pfam00501 161 IYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLgpdDRVLSTLPLFHDFGLSLGLLGPLLAGATVVLPPGFPALD- 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  261 PLIWPELITKYHGTTTAAPNFAYaivgRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARfkmpaeCVFPAY 340
Cdd:pfam00501 240 PAALLELIERYKVTVLYGVPTLL----NMLLEAGAPKRALLSSLRLVLSGGAPLPPELARRFRELFGG------ALVNGY 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  341 GMAEATLAVSFAPlftgltldvveadaleaenravPVPEGDPRRGTdgvrsfalLGRPLDGLEAEIVDDA-GKRVDEREV 419
Cdd:pfam00501 310 GLTETTGVVTTPL----------------------PLDEDLRSLGS--------VGRPLPGTEVKIVDDEtGEPVPPGEP 359
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  420 GEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYLV-DGQIVICGRRKDVIIMG 475
Cdd:pfam00501 360 GELCVRGPGVMKGYL--NDPELTAeafDEDGWYRTGDLGRRDeDGYLEIVGRKKDQIKLG 417
FAAL_FadD32 NF038339
long-chain-fatty-acid--AMP ligase FAAL32/FadD32; FadD32, also called FAAL32, is a marker ...
165-577 3.22e-52

long-chain-fatty-acid--AMP ligase FAAL32/FadD32; FadD32, also called FAAL32, is a marker enzyme for the biosynthesis of the type of mycolic acids, the very large "eumycolic acids", found in Mycobacterium.


Pssm-ID: 468483 [Multi-domain]  Cd Length: 625  Bit Score: 189.16  E-value: 3.22e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 165 AAEPLPDVV-------VTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMvg 237
Cdd:NF038339 157 AVDAVPDSVgstwvrpDADLDDIAYLQYTSGSTRVPAGVEITHRAVATNVLQMVDAIELDEN-SRGVTWLPLFHDMGL-- 233
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 238 fLTV--PMTFGVELVKITPVEFLSGPLIW-PELITK--YHGTTTAAPNFAYAIVGRRmARVDEDDAYDLSKLRIALNGAE 312
Cdd:NF038339 234 -LTVilPALGGKYITIMSPAAFVRRPGRWiRELAAVsdGAGTFAAAPNFAFEHAAAR-GLPKEGEPLDLSNVIGLINGSE 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 313 PIDETAVQTFVDAGARFKMPAECVFPAYGMAEATLAVSFAPLFTGLTLDVVEADALEAeNRAVPVPEGDPrrgtDGVRSF 392
Cdd:NF038339 312 PVTTSSMRKFNEAFAPYGLPKTAIKPSYGMAEATLFVSSTPREDEAKVIYVDREELNA-GRIVEVDPDAP----NAVAQV 386
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 393 AlLGRPLDGLEAEIVD-DAGKRVDEREVGEIRLRGEAVTPGYL--------TMDGPLATQDEDG-----------WLNTG 452
Cdd:NF038339 387 S-CGYVARSQWAVIVDpETGTELPDGQVGEIWLHGNNIGTGYWgrpeeteeTFHNKLKSRLEEGshaegapedanWMRTG 465
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 453 DLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIER--------------AATSV------EGVRAGNAVAVRLDAGSRRER 512
Cdd:NF038339 466 DYGVYYDGELYITGRVKDLVIVDGRNHYPQDLEYsaqeaskalrpgfvAAFSVpanqlpAEVFENSHSGLKYDADDSSEQ 545
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052 513 FAVVLEsKLAGDAEAEKnlmKQVSARVRDAVDMR----PYAVVVLPAGSLPKTPSGKVKRAATAQQFAD 577
Cdd:NF038339 546 LVIVAE-RAPGAGKADP---QPIADAVRAAIAVRhgvtVRDVLLVPAGSIPRTSSGKIARRACKAAYID 610
FAAL_FadD21 NF038337
fatty-acid--AMP ligase FAAL21/FadD21;
170-575 1.09e-49

fatty-acid--AMP ligase FAAL21/FadD21;


Pssm-ID: 439631 [Multi-domain]  Cd Length: 579  Bit Score: 181.23  E-value: 1.09e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVerAEFDFDVD-------VMVSWLPTFHDMGMVGFLTVP 242
Cdd:NF038337 155 PSIRISDAPSIAYLQYTSGSTRLPAGVMVSHRNLQVNFQQLM--AAYFPDTNgvaprdtTIVSWLPFYHDMGLVLGVIAP 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 243 MTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDAyDLSKLRIALNGAEPIDETAVQTF 322
Cdd:NF038337 233 ILGGYRSELTSPVAFLQRPARWIHAMANGSPVFSAAPNFAFELAVRKTTDADLAGL-DLGNVIGIVSGAERIHPATLDRF 311
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 323 VDAGARFKMPAECVFPAYGMAEATLAVsfaplftgltldvveadALEAENRAVPVPEGDPRRGTDGV--RSFALLGRPLD 400
Cdd:NF038337 312 CKRFAPYNFREDMMQPSYGLAEATVYV-----------------ASRAEGGAPEVVHFEPEKLSEGSaqRCEARTGSPLL 374
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEA------EIVD-DAGKRVDEREVGEIRLRGEAVTPGYL------------TMDGPLATQDEDGWLNTGDLGYLVDGQ 461
Cdd:NF038337 375 SYGTptsptvRIVDpDTCIECPAGTVGEIWVHGDNVAEGYWqkpeetrrtfggVLANPSPGTPEGPWLRTGDLGFISEDE 454
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 462 IVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGnAVAVRLDagsRRERFAVVLESKLAGDAEAEKN-----LMKQVS 536
Cdd:NF038337 455 MFIVGRMKDLLIVYGRNHYPEDIESTVQEITGGRVA-AISVPVD---ETEKLVTIIELKKRGDSDEEAMrkldaVKNNVT 530
                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 300790052 537 ARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKRAATAQQF 575
Cdd:NF038337 531 AAISRSHGLNVADLVLVPPGSIPTTTSGKIRRAACVEQY 569
FC-FACS_FadD_like cd05936
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...
30-568 1.15e-47

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341259 [Multi-domain]  Cd Length: 468  Bit Score: 173.13  E-value: 1.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  30 VRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLA--AAPVLIAptVQAVWLAGGSVTMLH-QPTPRtDLAEWAEDtvrvl 106
Cdd:cd05936   23 RKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLpnCPQFPIA--YFGALKAGAVVVPLNpLYTPR-ELEHILND----- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 107 gmigsdqdalggpgglaprpgSGAgprnVTVLLGEPFDQLapvleqkgigfqliteLAAAEPLPDVVVTDEGDTALLQLT 186
Cdd:cd05936   95 ---------------------SGA----KALIVAVSFTDL----------------LAAGAPLGERVALTPEDVAVLQYT 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 187 SGSTADPKAVRITYGNLYSNVKAMVERAEFDFDV-DVMVSWLPTFHDMGMVGFLTVPMTFGVELVKIT---PVEFLsgpl 262
Cdd:cd05936  134 SGTTGVPKGAMLTHRNLVANALQIKAWLEDLLEGdDVVLAALPLFHVFGLTVALLLPLALGATIVLIPrfrPIGVL---- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 263 iwpELITKYHGTTTAAPNFAYAIvgrrMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFvdaGARFKMPaecVFPAYGM 342
Cdd:cd05936  210 ---KEIRKHRVTIFPGVPTMYIA----LLNAPEFKKRDFSSLRLCISGGAPLPVEVAERF---EELTGVP---IVEGYGL 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 343 AEATLAVSFAPlftgltldvveadaleaenravpvPEGDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEI 422
Cdd:cd05936  277 TETSPVVAVNP------------------------LDGPRKPGS--------IGIPLPGTEVKIVDDDGEELPPGEVGEL 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 423 RLRGEAVTPGYLTMdgPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNA 499
Cdd:cd05936  325 WVRGPQVMKGYWNR--PEETAEafVDGWLRTGDIGYMdEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAV 402
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052 500 VAVRLDAGSRRERFAVVLESklaGDAEAEKNLMKQvsARVRDAVDMRPYAVVVLPAgsLPKTPSGKVKR 568
Cdd:cd05936  403 VGVPDPYSGEAVKAFVVLKE---GASLTEEEIIAF--CREQLAGYKVPRQVEFRDE--LPKSAVGKILR 464
FACL_FadD13-like cd17631
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...
30-566 1.29e-43

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.


Pssm-ID: 341286 [Multi-domain]  Cd Length: 435  Bit Score: 161.24  E-value: 1.29e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  30 VRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGgsvTMLHQPTPRTDLAEWAEdtvrvlgmI 109
Cdd:cd17631   19 RSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLG---AVFVPLNFRLTPPEVAY--------I 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 GSDQDAlggpgglaprpgsgagprnvTVLLGepfdqlapvleqkgigfqlitelaaaeplpdvvvtdegDTALLQLTSGS 189
Cdd:cd17631   88 LADSGA--------------------KVLFD--------------------------------------DLALLMYTSGT 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 190 TADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELV---KITPVEFLSgpliwpe 266
Cdd:cd17631  110 TGRPKGAMLTHRNLLWNAVNALAALDLGPD-DVLLVVAPLFHIGGLGVFTLPTLLRGGTVVilrKFDPETVLD------- 181
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 267 LITKYHGTTT-AAPNFAYAivgrrMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMpaecvfpAYGMAEA 345
Cdd:cd17631  182 LIERHRVTSFfLVPTMIQA-----LLQHPRFATTDLSSLRAVIYGGAPMPERLLRALQARGVKFVQ-------GYGMTET 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 346 TLAVSFAPlftgltldvvEADALEaenravpvpegdpRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLR 425
Cdd:cd17631  250 SPGVTFLS----------PEDHRR-------------KLGS--------AGRPVFFVEVRIVDPDGREVPPGEVGEIVVR 298
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 426 GEAVTPGYLtmDGPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRagnAVAV 502
Cdd:cd17631  299 GPHVMAGYW--NRPEATAAafRDGWFHTGDLGRLdEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVA---EVAV 373
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 503 rldAGSRRERF------AVVLESklaGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLPAgsLPKTPSGKV 566
Cdd:cd17631  374 ---IGVPDEKWgeavvaVVVPRP---GAELDEDELIAHCRERL--ARYKIPKSVEFVDA--LPRNATGKI 433
PRK06187 PRK06187
long-chain-fatty-acid--CoA ligase; Validated
163-577 1.68e-41

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235730 [Multi-domain]  Cd Length: 521  Bit Score: 157.27  E-value: 1.68e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 163 LAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMvGFLTVP 242
Cdd:PRK06187 152 LAAASDTFDFPDIDENDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRD-DVYLVIVPMFHVHAW-GLPYLA 229
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 243 MTFGVELVkiTPVEFLSGPLIwpELITKyHGTTT--AAPNFAYAIVGRRMARvdeddAYDLSKLRIALNGAEPIDETAVQ 320
Cdd:PRK06187 230 LMAGAKQV--IPRRFDPENLL--DLIET-ERVTFffAVPTIWQMLLKAPRAY-----FVDFSSLRLVIYGGAALPPALLR 299
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 321 TFVDagaRFKMPaecVFPAYGMAEATLAVSFAPLftgltldvveadalEAEnravpVPEGDPRRGTdgvrsfalLGRPLD 400
Cdd:PRK06187 300 EFKE---KFGID---LVQGYGMTETSPVVSVLPP--------------EDQ-----LPGQWTKRRS--------AGRPLP 346
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEAEIVDDAGKRV--DEREVGEIRLRGEAVTPGYLTMdgPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKDVIIMG 475
Cdd:PRK06187 347 GVEARIVDDDGDELppDGGEVGEIIVRGPWLMQGYWNR--PEATAEtiDGGWLHTGDVGYIdEDGYLYITDRIKDVIISG 424
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 476 GRNLYPTDIERAATSVEGVRAgnaVAV------RLDagsrrER-FAVVlesKLAGDAEA-EKNLMKQVSARVRDAVdmRP 547
Cdd:PRK06187 425 GENIYPRELEDALYGHPAVAE---VAVigvpdeKWG-----ERpVAVV---VLKPGATLdAKELRAFLRGRLAKFK--LP 491
                        410       420       430
                 ....*....|....*....|....*....|
gi 300790052 548 YAVVVLPAgsLPKTPSGKVKRAATAQQFAD 577
Cdd:PRK06187 492 KRIAFVDE--LPRTSVGKILKRVLREQYAE 519
Firefly_Luc_like cd05911
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...
33-566 7.20e-40

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341237 [Multi-domain]  Cd Length: 486  Bit Score: 151.98  E-value: 7.20e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHqP--TPRTdLAEWAEDT-VRVLGMI 109
Cdd:cd05911   12 TYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAAN-PiyTADE-LAHQLKISkPKVIFTD 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 GSDQDALggpggLAPRPGSGAGPRnVTVLLGEPFDQLAPvleqkgIGFQLITELAAAEPLPDVVVTDEGDTALLQLTSGS 189
Cdd:cd05911   90 PDGLEKV-----KEAAKELGPKDK-IIVLDDKPDGVLSI------EDLLSPTLGEEDEDLPPPLKDGKDDTAAILYSSGT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 190 TADPKAVRITYGNLYSNVKaMVERAEFDFDV--DVMVSWLPTFHDMGMVGFLTVpMTFGVELV---KITPVEFLsgpliw 264
Cdd:cd05911  158 TGLPKGVCLSHRNLIANLS-QVQTFLYGNDGsnDVILGFLPLYHIYGLFTTLAS-LLNGATVIimpKFDSELFL------ 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 265 pELITKYHGTTTA-APNFAYAivgrrMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFvdaGARFkmPAECVFPAYGMA 343
Cdd:cd05911  230 -DLIEKYKITFLYlVPPIAAA-----LAKSPLLDKYDLSSLRVILSGGAPLSKELQELL---AKRF--PNATIKQGYGMT 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 344 EATLAVSFAPlftgltldvveadaleaenravpvpEGDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDE-REVGEI 422
Cdd:cd05911  299 ETGGILTVNP-------------------------DGDDKPGS--------VGRLLPNVEAKIVDDDGKDSLGpNEPGEI 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 423 RLRGEAVTPGYLtmDGPLAT---QDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGN 498
Cdd:cd05911  346 CVRGPQVMKGYY--NNPEATketFDEDGWLHTGDIGYFdEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAA 423
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300790052 499 AVAVRLDAGSRRERFAVVLEsklAGDAEAEKNLMKQVSARVRDAVDMRPyAVVVLPAgsLPKTPSGKV 566
Cdd:cd05911  424 VIGIPDEVSGELPRAYVVRK---PGEKLTEKEVKDYVAKKVASYKQLRG-GVVFVDE--IPKSASGKI 485
FAA1 COG1022
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
3-579 6.04e-39

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];


Pssm-ID: 440645 [Multi-domain]  Cd Length: 603  Bit Score: 151.02  E-value: 6.04e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   3 RFVDTLVATATKRGQQRGMVTGEPKEPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGvlaaapvLIAPTV-------QA 75
Cdd:COG1022   12 TLPDLLRRRAARFPDRVALREKEDGIWQSLTWAEFAERVRALAAGLLALGVKPGDRVA-------ILSDNRpewviadLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  76 VWLAGGSVTMLHQPTPRTDLAEWAEDT-VRVLgmIGSDQDALGGpggLAPRPGSGAGPRNVTVllgepFDQLAPVLEQKG 154
Cdd:COG1022   85 ILAAGAVTVPIYPTSSAEEVAYILNDSgAKVL--FVEDQEQLDK---LLEVRDELPSLRHIVV-----LDPRGLRDDPRL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 155 IGFQLITELAAAEPLPDVV-----VTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPT 229
Cdd:COG1022  155 LSLDELLALGREVADPAELearraAVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPG-DRTLSFLPL 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 230 FH-----------DMGM-VGFLTVPMTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPN-----FAYAI-VGRRMA 291
Cdd:COG1022  234 AHvfertvsyyalAAGAtVAFAESPDTLAEDLREVKPTFMLAVPRVWEKVYAGIQAKAEEAGGlkrklFRWALaVGRRYA 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 292 RVDEDD------------AYD---LSKLR--------IALNGAEPIDETAVQTFVDAGarfkMPaecVFPAYGMAEATLA 348
Cdd:COG1022  314 RARLAGkspslllrlkhaLADklvFSKLRealggrlrFAVSGGAALGPELARFFRALG----IP---VLEGYGLTETSPV 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 349 VSFaplftgltldvveadaleaeNRavpvpEGDPRRGTdgvrsfalLGRPLDGLEAEIVDDagkrvderevGEIRLRGEA 428
Cdd:COG1022  387 ITV--------------------NR-----PGDNRIGT--------VGPPLPGVEVKIAED----------GEILVRGPN 423
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 429 VTPGYLtmDGPLATQ---DEDGWLNTGDLGYLV-DGQIVICGRRKDVIIM-GGRNLYPTDIERAATSVEGVraGNAVAVr 503
Cdd:COG1022  424 VMKGYY--KNPEATAeafDADGWLHTGDIGELDeDGFLRITGRKKDLIVTsGGKNVAPQPIENALKASPLI--EQAVVV- 498
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 504 ldaGSRR--------------ERFAVVLESKLAGDAEAEKNlmKQVSARVRDAVDM---------RPYAVVVLPA----- 555
Cdd:COG1022  499 ---GDGRpflaalivpdfealGEWAEENGLPYTSYAELAQD--PEVRALIQEEVDRanaglsraeQIKRFRLLPKeftie 573
                        650       660
                 ....*....|....*....|....*
gi 300790052 556 -GSLpkTPSGKVKRAATAQQFADRI 579
Cdd:COG1022  574 nGEL--TPTLKLKRKVILEKYADLI 596
VL_LC_FACS_like cd05907
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...
33-570 2.34e-37

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341233 [Multi-domain]  Cd Length: 452  Bit Score: 144.28  E-value: 2.34e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAApvliaptvQAVWLAggsvtmlhqptprTDLAEWAedtvrvLGMIgsd 112
Cdd:cd05907    7 TWAEFAEEVRALAKGLIALGVEPGDRVAILSRN--------RPEWTI-------------ADLAILA------IGAV--- 56
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 qdalggpgglaprpgsgagprNVTVLLGEPFDQLAPVLEQKGIgfqlitelaaaeplpDVVVTDEG-DTALLQLTSGSTA 191
Cdd:cd05907   57 ---------------------PVPIYPTSSAEQIAYILNDSEA---------------KALFVEDPdDLATIIYTSGTTG 100
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 192 DPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHDMGMVGFLTVPMTFGVELV-------------KITPVEFL 258
Cdd:cd05907  101 RPKGVMLSHRNILSNALALAERLPAT-EGDRHLSFLPLAHVFERRAGLYVPLLAGARIYfassaetllddlsEVRPTVFL 179
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 SGPLIWPELITKYHGttTAAPNFAYAIVGRRMarvdeddaydLSKLRIALNGAEPIDETAVQTFVDAGarfkMPaecVFP 338
Cdd:cd05907  180 AVPRVWEKVYAAIKV--KAVPGLKRKLFDLAV----------GGRLRFAASGGAPLPAELLHFFRALG----IP---VYE 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 339 AYGMAEATLAVSFAPLftgltldvveadaleaenravpvpeGDPRRGTdgvrsfalLGRPLDGLEAEIVDDagkrvdere 418
Cdd:cd05907  241 GYGLTETSAVVTLNPP-------------------------GDNRIGT--------VGKPLPGVEVRIADD--------- 278
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 419 vGEIRLRGEAVTPGYLTMDGPLATQ-DEDGWLNTGDLGYL-VDGQIVICGRRKDVIIM-GGRNLYPTDIERAATSVEGV- 494
Cdd:cd05907  279 -GEILVRGPNVMLGYYKNPEATAEAlDADGWLHTGDLGEIdEDGFLHITGRKKDLIITsGGKNISPEPIENALKASPLIs 357
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 495 --------RAGNAVAVRLDAGS-----RRERFAVVLESKLAGDAEAEKNL---MKQVSARVRDAVDMRPYAVVVLP---- 554
Cdd:cd05907  358 qavvigdgRPFLVALIVPDPEAleawaEEHGIAYTDVAELAANPAVRAEIeaaVEAANARLSRYEQIKKFLLLPEPftie 437
                        570
                 ....*....|....*.
gi 300790052 555 AGSLpkTPSGKVKRAA 570
Cdd:cd05907  438 NGEL--TPTLKLKRPV 451
FACL_fum10p_like cd05926
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...
162-573 1.11e-34

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.


Pssm-ID: 341249 [Multi-domain]  Cd Length: 493  Bit Score: 137.06  E-value: 1.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 162 ELAAAEPLPDVVVT----DEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVG 237
Cdd:cd05926  129 SLSNLLADKKNAKSegvpLPDDLALILHTSGTTGRPKGVPLTHRNLAASATNITNTYKLTPD-DRTLVVMPLFHVHGLVA 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 238 FLTVPMTFGVELVkiTPVEFlSGPLIWPElITKYHGT-TTAAPNFAYAIvgrrMARVDEDDAYDLSKLRIALNGAEPIDE 316
Cdd:cd05926  208 SLLSTLAAGGSVV--LPPRF-SASTFWPD-VRDYNATwYTAVPTIHQIL----LNRPEPNPESPPPKLRFIRSCSASLPP 279
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 317 tavQTFVDAGARFKMPaecVFPAYGMAEATLAVSFAPLftgltldvveadaleaenravpvPEGDPRRGTdgvrsfalLG 396
Cdd:cd05926  280 ---AVLEALEATFGAP---VLEAYGMTEAAHQMTSNPL-----------------------PPGPRKPGS--------VG 322
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 397 RPlDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQD---EDGWLNTGDLGYL-VDGQIVICGRRKDVI 472
Cdd:cd05926  323 KP-VGVEVRILDEDGEILPPGVVGEICLRGPNVTRGYL--NNPEANAEaafKDGWFRTGDLGYLdADGYLFLTGRIKELI 399
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 473 IMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQ------VSARVRdAVDmr 546
Cdd:cd05926  400 NRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAAAVVLREGASVTEEELRAFCRKhlaafkVPKKVY-FVD-- 476
                        410       420
                 ....*....|....*....|....*..
gi 300790052 547 pyavvvlpagSLPKTPSGKVKRAATAQ 573
Cdd:cd05926  477 ----------ELPKTATGKIQRRKVAE 493
PRK07656 PRK07656
long-chain-fatty-acid--CoA ligase; Validated
5-574 1.41e-34

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236072 [Multi-domain]  Cd Length: 513  Bit Score: 137.34  E-value: 1.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   5 VDTLVATATKRGQQRGMVTGEpkepVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAA--APVLIAptVQAVWLAGGS 82
Cdd:PRK07656   8 PELLARAARRFGDKEAYVFGD----QRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPnsPHWVIA--ALGALKAGAV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  83 VTMLHqptPRTDLAEWAEDTVRvlgmigSDQDALGGPGGLAP--RPGSGAGP--RNVTVLLGEPfdqlapvLEQKGIGFQ 158
Cdd:PRK07656  82 VVPLN---TRYTADEAAYILAR------GDAKALFVLGLFLGvdYSATTRLPalEHVVICETEE-------DDPHTEKMK 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 159 LITE-LAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGM-V 236
Cdd:PRK07656 146 TFTDfLAAGDPAERAPEVDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEG-DRYLAANPFFHVFGYkA 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 237 GFLTVPMTFG--VELVKITPVEFLsgpliwpELITKYHGTTTAAP----NFAYAIVGRrmarvdedDAYDLSKLRIALNG 310
Cdd:PRK07656 225 GVNAPLMRGAtiLPLPVFDPDEVF-------RLIETERITVLPGPptmyNSLLQHPDR--------SAEDLSSLRLAVTG 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 311 AEPIDETAVQTFvdagaRFKMPAECVFPAYGMAEATLAVSFAPLftgltldvveadaleaenravpvpeGDPRRGTDGVr 390
Cdd:PRK07656 290 AASMPVALLERF-----ESELGVDIVLTGYGLSEASGVTTFNRL-------------------------DDDRKTVAGT- 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 391 sfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQ---DEDGWLNTGDLGYL-VDGQIVICG 466
Cdd:PRK07656 339 ----IGTAIAGVENKIVNELGEEVPVGEVGELLVRGPNVMKGYYDD--PEATAaaiDADGWLHTGDLGRLdEEGYLYIVD 412
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 467 RRKDVIIMGGRNLYPTDIER--------AATSVEGV---RAGNAVavrldagsrreRFAVVLESKLAGDAEAeknLMKQv 535
Cdd:PRK07656 413 RKKDMFIVGGFNVYPAEVEEvlyehpavAEAAVIGVpdeRLGEVG-----------KAYVVLKPGAELTEEE---LIAY- 477
                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 300790052 536 sARVRDAVDMRPYAVVVLPAgsLPKTPSGKVKRAATAQQ 574
Cdd:PRK07656 478 -CREHLAKYKVPRSIEFLDE--LPKNATGKVLKRALREK 513
CHC_CoA_lg cd05903
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...
31-568 5.71e-34

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.


Pssm-ID: 341229 [Multi-domain]  Cd Length: 437  Bit Score: 134.05  E-value: 5.71e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  31 RRTWAEVHEEARRIAGGLVAGGFERGTAVGVLaaapvliaptvqavwlaggsvtmlhqptprtdLAEWAEDTVRVLGmig 110
Cdd:cd05903    1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQ--------------------------------LPNWWEFAVLYLA--- 45
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 111 sdqdalggpgglaprpgsgagprnvTVLLGEPFDQLAPVLEQKGIGFQLITELAAAEPLPDV-----VVTDEGDTALLQL 185
Cdd:cd05903   46 -------------------------CLRIGAVTNPILPFFREHELAFILRRAKAKVFVVPERfrqfdPAAMPDAVALLLF 100
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 186 TSGSTADPKAVRITYGNLYSNVKAMVERAEFDF-DVDVMVSwlPTFHDMGMVGFLTVPMTFGvelvkiTPVEFLSgplIW 264
Cdd:cd05903  101 TSGTTGEPKGVMHSHNTLSASIRQYAERLGLGPgDVFLVAS--PMAHQTGFVYGFTLPLLLG------APVVLQD---IW 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 265 P-----ELITKYHGTTT-AAPNFAYAIVgrrmaRVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARFkmpaecVFP 338
Cdd:cd05903  170 DpdkalALMREHGVTFMmGATPFLTDLL-----NAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAK------VCS 238
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 339 AYGMAEATLAVSfaplftgltldvveadaleaenrAVPVPEGDPRRGTDGvrsfallgRPLDGLEAEIVDDAGKRVDERE 418
Cdd:cd05903  239 AYGSTECPGAVT-----------------------SITPAPEDRRLYTDG--------RPLPGVEIKVVDDTGATLAPGV 287
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 419 VGEIRLRGEAVTPGYLtmDGPLATQD--EDGWLNTGDLGYLVD-GQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVR 495
Cdd:cd05903  288 EGELLSRGPSVFLGYL--DRPDLTADaaPEGWFRTGDLARLDEdGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVI 365
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300790052 496 AGNAVAV---RLdaGSRRERFaVVLESKLAGDAEAeknlMKQVSARVRDAVDMRPYAVVVLPAgsLPKTPSGKVKR 568
Cdd:cd05903  366 EAAVVALpdeRL--GERACAV-VVTKSGALLTFDE----LVAYLDRQGVAKQYWPERLVHVDD--LPRTPSGKVQK 432
PRK07529 PRK07529
AMP-binding domain protein; Validated
28-566 8.52e-33

AMP-binding domain protein; Validated


Pssm-ID: 236043 [Multi-domain]  Cd Length: 632  Bit Score: 133.16  E-value: 8.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  28 EPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLA------------------AAPV--LIAPTVQAVWL--AGGSVTM 85
Cdd:PRK07529  55 RPETWTYAELLADVTRTANLLHSLGVGPGDVVAFLLpnlpethfalwggeaagiANPInpLLEPEQIAELLraAGAKVLV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  86 LHQPTPRTDLAEWAEDTVR----VLGMIGSD-QDALGGPGGLAPRPGSGAGPRNVtvllgepFDQLAPVLEQKGigfqli 160
Cdd:PRK07529 135 TLGPFPGTDIWQKVAEVLAalpeLRTVVEVDlARYLPGPKRLAVPLIRRKAHARI-------LDFDAELARQPG------ 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 161 TELAAAEPLpdvvvtDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLT 240
Cdd:PRK07529 202 DRLFSGRPI------GPDDVAAYFHTGGTTGMPKLAQHTHGNEVANAWLGALLLGLGPG-DTVFCGLPLFHVNALLVTGL 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 241 VPMTFGVELVKITPVEFlSGPL----IWpELITKYHGTTTAAPNFAYAIVGRRMArvdedDAYDLSKLRIALNGAEPIDE 316
Cdd:PRK07529 275 APLARGAHVVLATPQGY-RGPGvianFW-KIVERYRINFLSGVPTVYAALLQVPV-----DGHDISSLRYALCGAAPLPV 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 317 TAVQTFVDA-GARfkmpaecVFPAYGMAEATLAVSFAPlftgltldvveadaleaenravpvPEGDPRRGTdgvrsfalL 395
Cdd:PRK07529 348 EVFRRFEAAtGVR-------IVEGYGLTEATCVSSVNP------------------------PDGERRIGS--------V 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIV--DDAGKRVDE---REVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRK 469
Cdd:PRK07529 389 GLRLPYQRVRVVilDDAGRYLRDcavDEVGVLCIAGPNVFSGYLEAAHNKGLWLEDGWLNTGDLGRIdADGYFWLTGRAK 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 470 DVIIMGGRNLYPTDIERAATSVEGVRAGNAVAvRLDAGSRRERFAVVlesKLAGDAEA-EKNLMKQVSARV--RDAVdmr 546
Cdd:PRK07529 469 DLIIRGGHNIDPAAIEEALLRHPAVALAAAVG-RPDAHAGELPVAYV---QLKPGASAtEAELLAFARDHIaeRAAV--- 541
                        570       580
                 ....*....|....*....|
gi 300790052 547 PYAVVVLPAgsLPKTPSGKV 566
Cdd:PRK07529 542 PKHVRILDA--LPKTAVGKI 559
LC_FACL_like cd05914
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...
172-568 2.91e-32

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341240 [Multi-domain]  Cd Length: 463  Bit Score: 129.87  E-value: 2.91e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAmVERAEFDFDVDVMVSWLPTFHDMGMVGFLTVPMTFGVELVK 251
Cdd:cd05914   83 IFVSDEDDVALINYTSGTTGNSKGVMLTYRNIVSNVDG-VKEVVLLGKGDKILSILPLHHIYPLTFTLLLPLLNGAHVVF 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 252 ITPvefLSGPLIwpELITKYHGTTTAAPNFAYAIVGRRmaRVDEDDAYDLSKLRIALNG---AEPIDETAVQTFVDA-GA 327
Cdd:cd05914  162 LDK---IPSAKI--IALAFAQVTPTLGVPVPLVIEKIF--KMDIIPKLTLKKFKFKLAKkinNRKIRKLAFKKVHEAfGG 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 328 RFK--------MPAE----------CVFPAYGMAEATLAVSFAPlftgltldvveadaleaENRAVpvpegdprrgtdgv 389
Cdd:cd05914  235 NIKefviggakINPDveeflrtigfPYTIGYGMTETAPIISYSP-----------------PNRIR-------------- 283
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 390 rsFALLGRPLDGLEAEIVDDAGKRVDerevGEIRLRGEAVTPGYltMDGPLATQ---DEDGWLNTGDLGYLV-DGQIVIC 465
Cdd:cd05914  284 --LGSAGKVIDGVEVRIDSPDPATGE----GEIIVRGPNVMKGY--YKNPEATAeafDKDGWFHTGDLGKIDaEGYLYIR 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 466 GRRKDVIIMG-GRNLYPTDIE-------RAATSVEGVRAGNAVA-VRLDAGSrrerfavvLESKLAGDAEAEKNLMKQVS 536
Cdd:cd05914  356 GRKKEMIVLSsGKNIYPEEIEakinnmpFVLESLVVVQEKKLVAlAYIDPDF--------LDVKALKQRNIIDAIKWEVR 427
                        410       420       430
                 ....*....|....*....|....*....|...
gi 300790052 537 ARV-RDAVDMRPYAVVVLPAGSLPKTPSGKVKR 568
Cdd:cd05914  428 DKVnQKVPNYKKISKVKIVKEEFEKTPKGKIKR 460
OSB_CoA_lg cd05912
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...
179-568 5.01e-32

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.


Pssm-ID: 341238 [Multi-domain]  Cd Length: 411  Bit Score: 128.23  E-value: 5.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHdmgmVGFLTVPMTFGVELVKITPVEFL 258
Cdd:cd05912   78 DIATIMYTSGTTGKPKGVQQTFGNHWWSAIGSALNLGLT-EDDNWLCALPLFH----ISGLSILMRSVIYGMTVYLVDKF 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 SGPLIwPELITKYHGTTTAApnfAYAIVGRRMARVDEDDAYDLsklRIALNGAEPIDETAVQTFVDAGarfkMPaecVFP 338
Cdd:cd05912  153 DAEQV-LHLINSGKVTIISV---VPTMLQRLLEILGEGYPNNL---RCILLGGGPAPKPLLEQCKEKG----IP---VYQ 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 339 AYGMAE-ATLAVSFAPLFTGLTLDVVeadaleaenravpvpegdprrgtdgvrsfallGRPLDGLEAEIVDDAGKrvdER 417
Cdd:cd05912  219 SYGMTEtCSQIVTLSPEDALNKIGSA--------------------------------GKPLFPVELKIEDDGQP---PY 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 418 EVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRA 496
Cdd:cd05912  264 EVGEILLKGPNVTKGYLNRPDATEESFENGWFKTGDIGYLdEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPAIKE 343
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300790052 497 GNAVAVRLDAGSRRERFAVVLESKLagdaeAEKNLMKQVSARVrdAVDMRPYAVVVLpaGSLPKTPSGKVKR 568
Cdd:cd05912  344 AGVVGIPDDKWGQVPVAFVVSERPI-----SEEELIAYCSEKL--AKYKVPKKIYFV--DELPRTASGKLLR 406
menE TIGR01923
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ...
33-570 2.55e-31

O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 162605 [Multi-domain]  Cd Length: 436  Bit Score: 126.41  E-value: 2.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmigSD 112
Cdd:TIGR01923   1 TWQDLDCEAAHLAKALKAQGIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLED---------LD 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  113 QDALggpggLAPRPgsgagprnvtvllgepfdqlapvLEQKGIGFQLITELAAAEPLPDVVVTDEG--DTALLQLTSGST 190
Cdd:TIGR01923  72 VQLL-----LTDSL-----------------------LEEKDFQADSLDRIEAAGRYETSLSASFNmdQIATLMFTSGTT 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  191 ADPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHDMGmVGFLTVPMTFGVELVKITPVEFLSgpliwpELITk 270
Cdd:TIGR01923 124 GKPKAVPHTFRNHYASAVGSKENLGFT-EDDNWLLSLPLYHISG-LSILFRWLIEGATLRIVDKFNQLL------EMIA- 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  271 yHGTTTAApnfayAIVGRRMARVDEDDAYDLSkLRIALNGAEPIDETAVQTFVDAGarfkMPaecVFPAYGMAEATLAVS 350
Cdd:TIGR01923 195 -NERVTHI-----SLVPTQLNRLLDEGGHNEN-LRKILLGGSAIPAPLIEEAQQYG----LP---IYLSYGMTETCSQVT 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  351 FAPlftgltldvveadaleaenravpvPEGDPRRGTdgvrsfalLGRPLDGLEAEIvddagKRVDEREVGEIRLRGEAVT 430
Cdd:TIGR01923 261 TAT------------------------PEMLHARPD--------VGRPLAGREIKI-----KVDNKEGHGEIMVKGANLM 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  431 PGYLTmDGPL-ATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGS 508
Cdd:TIGR01923 304 KGYLY-QGELtPAFEQQGWFNTGDIGELdGEGFLYVLGRRDDLIISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWG 382
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300790052  509 RRERFAVVLESKLAgDAEAEKNLMKQVsARVRdavdmRPYAVVVLPagSLPKTPSGKVKRAA 570
Cdd:TIGR01923 383 QVPVAYIVSESDIS-QAKLIAYLTEKL-AKYK-----VPIAFEKLD--ELPYNASGKILRNQ 435
DltA cd05945
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...
163-570 3.74e-31

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341267 [Multi-domain]  Cd Length: 449  Bit Score: 126.21  E-value: 3.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 163 LAAAEPlpDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVER------------AEFDFDVDVMvSWLPTf 230
Cdd:cd05945   84 LDAAKP--ALLIADGDDNAYIIFTSGSTGRPKGVQISHDNLVSFTNWMLSDfplgpgdvflnqAPFSFDLSVM-DLYPA- 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 231 hdmgmvgfLTVPMTfgvelVKITPVEFLSGPLIWPELITKyHGTT--TAAPNFAyaivgrRMARVDEDDAYD-LSKLRIA 307
Cdd:cd05945  160 --------LASGAT-----LVPVPRDATADPKQLFRFLAE-HGITvwVSTPSFA------AMCLLSPTFTPEsLPSLRHF 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 308 LNGAEPIDETAVQTFVdagARFkmPAECVFPAYGMAEATLAVsfaplftglTLDVVEADALEAENRaVPVpegdprrgtd 387
Cdd:cd05945  220 LFCGEVLPHKTARALQ---QRF--PDARIYNTYGPTEATVAV---------TYIEVTPEVLDGYDR-LPI---------- 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 388 gvrsfallGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQ------DEDGWLNTGDLGYLV-DG 460
Cdd:cd05945  275 --------GYAKPGAKLVILDEDGRPVPPGEKGELVISGPSVSKGYL--NNPEKTAaaffpdEGQRAYRTGDLVRLEaDG 344
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 461 QIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAgnAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVR 540
Cdd:cd05945  345 LLFYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKE--AVVVPKYKGEKVTELIAFVVPKPGAEAGLTKAIKAELAERLP 422
                        410       420       430
                 ....*....|....*....|....*....|
gi 300790052 541 DAvdMRPYAVVVLPagSLPKTPSGKVKRAA 570
Cdd:cd05945  423 PY--MIPRRFVYLD--ELPLNANGKIDRKA 448
ttLC_FACS_AlkK_like cd12119
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
22-569 1.44e-29

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.


Pssm-ID: 341284 [Multi-domain]  Cd Length: 518  Bit Score: 122.74  E-value: 1.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  22 VTGEPKEPVRR-TWAEVHEEARRIAGGLVAGGFERGTAVGVLA-----------AAPVLiaptvqavwlagGSVtmLHQP 89
Cdd:cd12119   15 VSRTHEGEVHRyTYAEVAERARRLANALRRLGVKPGDRVATLAwnthrhlelyyAVPGM------------GAV--LHTI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  90 TPR--TDLAEW----AEDtvRVLgMIGSDQDALGGPggLAPRPGSGAGPRNVTVLLGEPFDQLAPVLEQKgigfqliTEL 163
Cdd:cd12119   81 NPRlfPEQIAYiinhAED--RVV-FVDRDFLPLLEA--IAPRLPTVEHVVVMTDDAAMPEPAGVGVLAYE-------ELL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 164 AAAEPLPDVVVTDEGDTALLQLTSGSTADPKAV----RITY----GNLYSNVKAMVERaefdfdvDVMVSWLPTFHDMGM 235
Cdd:cd12119  149 AAESPEYDWPDFDENTAAAICYTSGTTGNPKGVvyshRSLVlhamAALLTDGLGLSES-------DVVLPVVPMFHVNAW 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 236 VGFLTVPMTfGVELVkitpvefLSGPLIWP----ELITKYHGTTTAA-PNFAYAIvgrrMARVDEDDaYDLSKLRIALNG 310
Cdd:cd12119  222 GLPYAAAMV-GAKLV-------LPGPYLDPaslaELIEREGVTFAAGvPTVWQGL----LDHLEANG-RDLSSLRRVVIG 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 311 AEPIDETAVQTFVDAGARfkmpaecVFPAYGMAEATlavsfaPLFTGLTLDVVEADALEAENRAVpvpegdpRRGTdgvr 390
Cdd:cd12119  289 GSAVPRSLIEAFEERGVR-------VIHAWGMTETS------PLGTVARPPSEHSNLSEDEQLAL-------RAKQ---- 344
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 391 sfallGRPLDGLEAEIVDDAGKRV--DEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGR 467
Cdd:cd12119  345 -----GRPVPGVELRIVDDDGRELpwDGKAVGELQVRGPWVTKSYYKNDEESEALTEDGWLRTGDVATIdEDGYLTITDR 419
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 468 RKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLEsklAGDAEAEKNLMKQVSARVrdAVDMRP 547
Cdd:cd12119  420 SKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGERPLAVVVLK---EGATVTAEELLEFLADKV--AKWWLP 494
                        570       580
                 ....*....|....*....|...
gi 300790052 548 YAVVVLPAgsLPKTPSGKV-KRA 569
Cdd:cd12119  495 DDVVFVDE--IPKTSTGKIdKKA 515
4CL cd05904
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...
33-472 1.60e-29

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.


Pssm-ID: 341230 [Multi-domain]  Cd Length: 505  Bit Score: 122.34  E-value: 1.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDTVRVLGMIGSD 112
Cdd:cd05904   34 TYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPAEIAKQVKDSGAKLAFTTAE 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 qdalggpggLAPRPGSGAGPrnvTVLLGE-PFDQLAPVLEQKgigfqlitelAAAEPLPDVVVTDEGDTALLQLTSGSTA 191
Cdd:cd05904  114 ---------LAEKLASLALP---VVLLDSaEFDSLSFSDLLF----------EADEAEPPVVVIKQDDVAALLYSSGTTG 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 192 DPKAVRITYGNLYSNVKAMVERAEFDFDV-DVMVSWLPTFHDMGMVGFLTVPMTFGVELVkITPVEFLSGPLiwpELITK 270
Cdd:cd05904  172 RSKGVMLTHRNLIAMVAQFVAGEGSNSDSeDVFLCVLPMFHIYGLSSFALGLLRLGATVV-VMPRFDLEELL---AAIER 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 271 YHGT-TTAAPNFAYAIVGRRMArvdedDAYDLSKLRIALNGAEPIDETAVQTFvdagaRFKMPAECVFPAYGMAEATLAV 349
Cdd:cd05904  248 YKVThLPVVPPIVLALVKSPIV-----DKYDLSSLRQIMSGAAPLGKELIEAF-----RAKFPNVDLGQGYGMTESTGVV 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 350 SfaplftgltldvveadaleaenrAVPVPEGDPRRGTDgvrsfalLGRPLDGLEAEIVD-DAGKRVDEREVGEIRLRGEA 428
Cdd:cd05904  318 A-----------------------MCFAPEKDRAKYGS-------VGRLVPNVEAKIVDpETGESLPPNQTGELWIRGPS 367
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 300790052 429 VTPGYLtmDGPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKDVI 472
Cdd:cd05904  368 IMKGYL--NNPEATAatiDKEGWLHTGDLCYIdEDGYLFIVDRLKELI 413
PRK12583 PRK12583
acyl-CoA synthetase; Provisional
30-485 4.55e-29

acyl-CoA synthetase; Provisional


Pssm-ID: 237145 [Multi-domain]  Cd Length: 558  Bit Score: 121.42  E-value: 4.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  30 VRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLA-----------------AAPVLIAPTVQAVWLAggsvTMLHQPTPR 92
Cdd:PRK12583  44 LRYTWRQLADAVDRLARGLLALGVQPGDRVGIWApncaewlltqfatarigAILVNINPAYRASELE----YALGQSGVR 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  93 TDLAEWAEDTVRVLGMIGS--DQDALGGPGGLAPR--PGSgagpRNVTVLLGEP------FDQLAPvlEQKGIGFQLITE 162
Cdd:PRK12583 120 WVICADAFKTSDYHAMLQEllPGLAEGQPGALACErlPEL----RGVVSLAPAPppgflaWHELQA--RGETVSREALAE 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 163 LAAAeplpdvvvTDEGDTALLQLTSGSTADPKAVRITYGNLYSNvKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLTVP 242
Cdd:PRK12583 194 RQAS--------LDRDDPINIQYTSGTTGFPKGATLSHHNILNN-GYFVAESLGLTEHDRLCVPVPLYHCFGMVLANLGC 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 243 MTFGVELvkITPVEFLSgPLIWPELITKYHGTTTaapnfaYAIVGRRMARVD--EDDAYDLSKLRIALNGAEPIDETAVQ 320
Cdd:PRK12583 265 MTVGACL--VYPNEAFD-PLATLQAVEEERCTAL------YGVPTMFIAELDhpQRGNFDLSSLRTGIMAGAPCPIEVMR 335
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 321 TFVDagarfKMPAECVFPAYGMAEATlavsfaPLftglTLDVVEADALEaenravpvpegdprrgtdgvRSFALLGRPLD 400
Cdd:PRK12583 336 RVMD-----EMHMAEVQIAYGMTETS------PV----SLQTTAADDLE--------------------RRVETVGRTQP 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQ-DEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRN 478
Cdd:PRK12583 381 HLEVKVVDPDGATVPRGEIGELCTRGYSVMKGYWNNPEATAESiDEDGWMHTGDLATMdEQGYVRIVGRSKDMIIRGGEN 460

                 ....*..
gi 300790052 479 LYPTDIE 485
Cdd:PRK12583 461 IYPREIE 467
PRK06087 PRK06087
medium-chain fatty-acid--CoA ligase;
143-583 4.73e-29

medium-chain fatty-acid--CoA ligase;


Pssm-ID: 180393 [Multi-domain]  Cd Length: 547  Bit Score: 121.39  E-value: 4.73e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 143 FDQLAPVLEQkgigFQLITELAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDV 222
Cdd:PRK06087 156 VDKLAPATSS----LSLSQIIADYEPLTTAITTHGDELAAVLFTSGTEGLPKGVMLTHNNILASERAYCARLNLTWQ-DV 230
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 223 MVSWLPTFHDMGMVGFLTVPMTFG---VELVKITPVEFLSgpLIWPELITKYHGTTTaapnFAYAIVgrrmaRVDEDDAY 299
Cdd:PRK06087 231 FMMPAPLGHATGFLHGVTAPFLIGarsVLLDIFTPDACLA--LLEQQRCTCMLGATP----FIYDLL-----NLLEKQPA 299
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 300 DLSKLRIALNGAEPIDETAVQtfvDAGARFKMPAECvfpaYGMAEATLAVsFAPLftgltldvveADALEaenravpvpe 379
Cdd:PRK06087 300 DLSALRFFLCGGTTIPKKVAR---ECQQRGIKLLSV----YGSTESSPHA-VVNL----------DDPLS---------- 351
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 380 gdprrgtdgvRSFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGY 456
Cdd:PRK06087 352 ----------RFMHTDGYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYL--DEPELTAralDEEGWYYSGDLCR 419
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 457 L-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAV---RLdaGSRRERFAVVLESKLAGDAEAEKNLM 532
Cdd:PRK06087 420 MdEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMpdeRL--GERSCAYVVLKAPHHSLTLEEVVAFF 497
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 300790052 533 kqvsARVRDAVDMRPYAVVVLPAgsLPKTPSGKVKRAATAQQFADRIKKNA 583
Cdd:PRK06087 498 ----SRKRVAKYKYPEHIVVIDK--LPRTASGKIQKFLLRKDIMRRLTQDV 542
AA-adenyl-dom TIGR01733
amino acid adenylation domain; This model represents a domain responsible for the specific ...
33-501 9.22e-29

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.


Pssm-ID: 273779 [Multi-domain]  Cd Length: 409  Bit Score: 118.52  E-value: 9.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   33 TWAEVHEEARRIAGGLVA-GGFERGTAVGVLAA--APVLIAptVQAVWLAGGSVTML--HQPTPRtdLAEWAEDT-VRVL 106
Cdd:TIGR01733   1 TYRELDERANRLARHLRAaGGVGPGDRVAVLLErsAELVVA--ILAVLKAGAAYVPLdpAYPAER--LAFILEDAgARLL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  107 gmigsdqdaLGGPGGLAPRPGSGAGPRNVTVLLGEPFDQLAPvleqkgigfqliTELAAAEPLPDvvvtdegDTALLQLT 186
Cdd:TIGR01733  77 ---------LTDSALASRLAGLVLPVILLDPLELAALDDAPA------------PPPPDAPSGPD-------DLAYVIYT 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  187 SGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTvPMTFGVELVKITPVEFLSGPLIWPE 266
Cdd:TIGR01733 129 SGSTGRPKGVVVTHRSLVNLLAWLARRYGLDPD-DRVLQFASLSFDASVEEIFG-ALLAGATLVVPPEDEERDDAALLAA 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  267 LITkyHGTTTAApnfayAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFvdagaRFKMPAECVFPAYGMAEAT 346
Cdd:TIGR01733 207 LIA--EHPVTVL-----NLTPSLLALLAAALPPALASLRLVILGGEALTPALVDRW-----RARGPGARLINLYGPTETT 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  347 LAVSFAPLftgltldvveadALEAENRAVPVPegdprrgtdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRG 426
Cdd:TIGR01733 275 VWSTATLV------------DPDDAPRESPVP----------------IGRPLANTRLYVLDDDLRPVPVGVVGELYIGG 326
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  427 EAVTPGYLTMDG---------PLATQDEDGWLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRa 496
Cdd:TIGR01733 327 PGVARGYLNRPEltaerfvpdPFAGGDGARLYRTGDLVrYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGVR- 405

                  ....*
gi 300790052  497 gNAVA 501
Cdd:TIGR01733 406 -EAVV 409
FACL_DitJ_like cd05934
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
33-569 9.58e-29

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.


Pssm-ID: 341257 [Multi-domain]  Cd Length: 422  Bit Score: 118.93  E-value: 9.58e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAApvliAPTVQAVWLAggsvtmlhqptprtdlaewaedtvrvLGMIGSD 112
Cdd:cd05934    5 TYAELLRESARIAAALAALGIRPGDRVALMLDN----CPEFLFAWFA--------------------------LAKLGAV 54
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 qdalggpgglaprpgsgAGPRNvTVLLGepfDQLAPVLEQKGigfqlitelaaaeplPDVVVTDegdTALLQLTSGSTAD 192
Cdd:cd05934   55 -----------------LVPIN-TALRG---DELAYIIDHSG---------------AQLVVVD---PASILYTSGTTGP 95
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 193 PKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFH----DMGMVGFLTVPMTFgVELVKITPVEFlsgpliWPElI 268
Cdd:cd05934   96 PKGVVITHANLTFAGYYSARRFGLG-EDDVYLTVLPLFHinaqAVSVLAALSVGATL-VLLPRFSASRF------WSD-V 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 269 TKYHGTTTAAPNFAYAIVGRRMARVDEDDAydlsKLRIALNGAEPIDETAvqtfvDAGARFKMPaecVFPAYGMAEATLA 348
Cdd:cd05934  167 RRYGATVTNYLGAMLSYLLAQPPSPDDRAH----RLRAAYGAPNPPELHE-----EFEERFGVR---LLEGYGMTETIVG 234
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 349 VsfaplftgltldvveadaleaenrAVPVPEgdprrgTDGVRSFallGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGE- 427
Cdd:cd05934  235 V------------------------IGPRDE------PRRPGSI---GRPAPGYEVRIVDDDGQELPAGEPGELVIRGLr 281
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 428 --AVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRL 504
Cdd:cd05934  282 gwGFFKGYYNMPEATAEAMRNGWFHTGDLGYRdADGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPD 361
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300790052 505 DAGSRRERFAVVLEsklAGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLPagSLPKTPSGKVKRA 569
Cdd:cd05934  362 EVGEDEVKAVVVLR---PGETLDPEELFAFCEGQL--AYFKVPRYIRFVD--DLPKTPTEKVAKA 419
PRK05605 PRK05605
long-chain-fatty-acid--CoA ligase; Validated
162-568 7.15e-28

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235531 [Multi-domain]  Cd Length: 573  Bit Score: 118.18  E-value: 7.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 162 ELAAAEPLPDVVVTDE-----GDTALLQLTSGSTADPKAVRITYGNLYSN-------VKAMVERAEfdfdvdVMVSWLPT 229
Cdd:PRK05605 198 TLVDAAIGGDGSDVSHprptpDDVALILYTSGTTGKPKGAQLTHRNLFANaaqgkawVPGLGDGPE------RVLAALPM 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 230 FHDMGMVGFLTVPMTFGVELVKITPVEFlsgPLIWPelITKYHgTTTAAPnfAYAIVGRRMARVDEDDAYDLSKLRIALN 309
Cdd:PRK05605 272 FHAYGLTLCLTLAVSIGGELVLLPAPDI---DLILD--AMKKH-PPTWLP--GVPPLYEKIAEAAEERGVDLSGVRNAFS 343
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 310 GAEPIDETAVQTFVDA-GARfkmpaecVFPAYGMAEAtlavsfAPLFTGltldvveadaleaeNravpvPEGDPRR-GTD 387
Cdd:PRK05605 344 GAMALPVSTVELWEKLtGGL-------LVEGYGLTET------SPIIVG--------------N-----PMSDDRRpGYV 391
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 388 GVrsfallgrPLDGLEAEIVD--DAGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQD--EDGWLNTGDLGYL-VDGQI 462
Cdd:PRK05605 392 GV--------PFPDTEVRIVDpeDPDETMPDGEEGELLVRGPQVFKGYWNR--PEETAKsfLDGWFRTGDVVVMeEDGFI 461
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 463 VICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRda 542
Cdd:PRK05605 462 RIVDRIKELIITGGFNVYPAEVEEVLREHPGVEDAAVVGLPREDGSEEVVAAVVLEPGAALDPEGLRAYCREHLTRYK-- 539
                        410       420
                 ....*....|....*....|....*.
gi 300790052 543 VDMRPYAVVVLPAGSLpktpsGKVKR 568
Cdd:PRK05605 540 VPRRFYHVDELPRDQL-----GKVRR 560
FACL_like_4 cd05944
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
178-570 1.01e-27

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341266 [Multi-domain]  Cd Length: 359  Bit Score: 114.50  E-value: 1.01e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 178 GDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEF 257
Cdd:cd05944    2 DDVAAYFHTGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPD-DVLLCGLPLFHVNGSVVTLLTPLASGAHVVLAGPAGY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 258 LSGPL---IWpELITKYHGTTTAAPNFAYAIVGRRmarvdEDDAyDLSKLRIALNGAEPIDETAVQTFVDAgarFKMPae 334
Cdd:cd05944   81 RNPGLfdnFW-KLVERYRITSLSTVPTVYAALLQV-----PVNA-DISSLRFAMSGAAPLPVELRARFEDA---TGLP-- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 335 cVFPAYGMAEATLAVSFAPlftgltldvveadaleaenravpvPEGDPRRGTDGVR--SFALLGRPLDGLEAEIVDDAGK 412
Cdd:cd05944  149 -VVEGYGLTEATCLVAVNP------------------------PDGPKRPGSVGLRlpYARVRIKVLDGVGRLLRDCAPD 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 413 rvderEVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSV 491
Cdd:cd05944  204 -----EVGEICVAGPGVFGGYLYTEGNKNAFVADGWLNTGDLGRLdADGYLFITGRAKDLIIRGGHNIDPALIEEALLRH 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 492 EGVRAGNAVAvRLDAGSRRERFAVVlesKLAGDAEAEK-NLMKQVSARV--RDAVdmrPYAVVVLPagSLPKTPSGKVKR 568
Cdd:cd05944  279 PAVAFAGAVG-QPDAHAGELPVAYV---QLKPGAVVEEeELLAWARDHVpeRAAV---PKHIEVLE--ELPVTAVGKVFK 349

                 ..
gi 300790052 569 AA 570
Cdd:cd05944  350 PA 351
PRK13295 PRK13295
cyclohexanecarboxylate-CoA ligase; Reviewed
163-568 1.68e-27

cyclohexanecarboxylate-CoA ligase; Reviewed


Pssm-ID: 171961 [Multi-domain]  Cd Length: 547  Bit Score: 116.69  E-value: 1.68e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 163 LAAAEPLPDvvvtdegDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVP 242
Cdd:PRK13295 189 LARLRPGPD-------DVTQLIYTSGTTGEPKGVMHTANTLMANIVPYAERLGLGAD-DVILMASPMAHQTGFMYGLMMP 260
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 243 MTFGVELVKI---TPVEFLSgpLIWPELITkyhgTTTAAPNFAYaivgrRMARVDEDDAYDLSKLRIALNGAEPIDETAV 319
Cdd:PRK13295 261 VMLGATAVLQdiwDPARAAE--LIRTEGVT----FTMASTPFLT-----DLTRAVKESGRPVSSLRTFLCAGAPIPGALV 329
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 320 QTfvdagARFKMPAECVfPAYGMAEATLAvsfaplfTGLTLDvveaDALEaenravpvpegdprrgtdgvRSFALLGRPL 399
Cdd:PRK13295 330 ER-----ARAALGAKIV-SAWGMTENGAV-------TLTKLD----DPDE--------------------RASTTDGCPL 372
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 400 DGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATqDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRN 478
Cdd:PRK13295 373 PGVEVRVVDADGAPLPAGQIGRLQVRGCSNFGGYLKRPQLNGT-DADGWFDTGDLARIdADGYIRISGRSKDVIIRGGEN 451
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 479 LYPTDIERAATSVEGVRAGNAVAV---RLdaGSRRERFaVVLESKLAGDAEAEKNLMKqvSARVrdAVDMRPYAVVVLPA 555
Cdd:PRK13295 452 IPVVEIEALLYRHPAIAQVAIVAYpdeRL--GERACAF-VVPRPGQSLDFEEMVEFLK--AQKV--AKQYIPERLVVRDA 524
                        410
                 ....*....|...
gi 300790052 556 gsLPKTPSGKVKR 568
Cdd:PRK13295 525 --LPRTPSGKIQK 535
PRK06839 PRK06839
o-succinylbenzoate--CoA ligase;
135-578 1.79e-27

o-succinylbenzoate--CoA ligase;


Pssm-ID: 168698 [Multi-domain]  Cd Length: 496  Bit Score: 116.11  E-value: 1.79e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 135 VTVLLGEPFDQLAPVLEQKGIGFQ---LITELAAAE--PLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLY----S 205
Cdd:PRK06839 101 TTVLFVEKTFQNMALSMQKVSYVQrviSITSLKEIEdrKIDNFVEKNESASFIICYTSGTTGKPKGAVLTQENMFwnalN 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 206 NVKAMVERAEfdfdvDVMVSWLPTFHdMGMVGFLTVPMTF--GVELV--KITPVEFLSgpLIWPELITKYHGTTTaapnf 281
Cdd:PRK06839 181 NTFAIDLTMH-----DRSIVLLPLFH-IGGIGLFAFPTLFagGVIIVprKFEPTKALS--MIEKHKVTVVMGVPT----- 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 282 ayaiVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMpaecvfpAYGMAEATLAVSFaplftgltld 361
Cdd:PRK06839 248 ----IHQALINCSKFETTNLQSVRWFYNGGAPCPEELMREFIDRGFLFGQ-------GFGMTETSPTVFM---------- 306
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 362 vveadaleaenravpVPEGDPRRGTDGVrsfallGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLA 441
Cdd:PRK06839 307 ---------------LSEEDARRKVGSI------GKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDATE 365
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 442 TQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESk 520
Cdd:PRK06839 366 ETIQDGWLCTGDLARVdEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIAFIVKKS- 444
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 300790052 521 laGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLPagSLPKTPSGKVKRAATAQQFADR 578
Cdd:PRK06839 445 --SSVLIEKDVIEHCRLFL--AKYKIPKEIVFLK--ELPKNATGKIQKAQLVNQLKSR 496
PRK03640 PRK03640
o-succinylbenzoate--CoA ligase;
33-582 1.93e-27

o-succinylbenzoate--CoA ligase;


Pssm-ID: 235146 [Multi-domain]  Cd Length: 483  Bit Score: 115.83  E-value: 1.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmigsd 112
Cdd:PRK03640  29 TFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSREELLWQLDD----------- 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 qdalggpgglaprpgSGAgprnVTVLLGEPFDQlapvlEQKGIGFQLITELAAaEPLPDVVVT---DEGDTALLQLTSGS 189
Cdd:PRK03640  98 ---------------AEV----KCLITDDDFEA-----KLIPGISVKFAELMN-GPKEEAEIQeefDLDEVATIMYTSGT 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 190 TADPKAVRITYGN-LYSNVKAMVERAEFDFDvdvmvSWL---PTFHDMG---MVGFLTVPMTfgVELVKITPVEFLSgpl 262
Cdd:PRK03640 153 TGKPKGVIQTYGNhWWSAVGSALNLGLTEDD-----CWLaavPIFHISGlsiLMRSVIYGMR--VVLVEKFDAEKIN--- 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 263 iwpELITKYHGTTTAApnfAYAIVGRRMARVdEDDAYDlSKLRIALNGAEPIDETAVQTFVDAGarfkMPaecVFPAYGM 342
Cdd:PRK03640 223 ---KLLQTGGVTIISV---VSTMLQRLLERL-GEGTYP-SSFRCMLLGGGPAPKPLLEQCKEKG----IP---VYQSYGM 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 343 AE-ATLAVSFAPlftgltldvveADALEAENRAvpvpegdprrgtdgvrsfallGRPLDGLEAEIVDDaGKRVDEREVGE 421
Cdd:PRK03640 288 TEtASQIVTLSP-----------EDALTKLGSA---------------------GKPLFPCELKIEKD-GVVVPPFEEGE 334
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 422 IRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVragNAV 500
Cdd:PRK03640 335 IVVKGPNVTKGYLNREDATRETFQDGWFKTGDIGYLdEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGV---AEA 411
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 501 AVrldAGSRRERFAVVLESKLAGDAEAEKNLMKQVsARVRDAVDMRPYAVVVlpAGSLPKTPSGKVKRaataQQFADRIK 580
Cdd:PRK03640 412 GV---VGVPDDKWGQVPVAFVVKSGEVTEEELRHF-CEEKLAKYKVPKRFYF--VEELPRNASGKLLR----HELKQLVE 481

                 ..
gi 300790052 581 KN 582
Cdd:PRK03640 482 EM 483
A_NRPS cd05930
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...
170-570 3.76e-27

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341253 [Multi-domain]  Cd Length: 444  Bit Score: 114.55  E-value: 3.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTvPMTFGVEL 249
Cdd:cd05930   85 AKLVLTDPDDLAYVIYTSGSTGKPKGVMVEHRGLVNLLLWMQEAYPLTPG-DRVLQFTSFSFDVSVWEIFG-ALLAGATL 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 250 VKITPVEFLSGPLIWPEL----ITKYHGTTTAAPNFayaivgrrmarVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDA 325
Cdd:cd05930  163 VVLPEEVRKDPEALADLLaeegITVLHLTPSLLRLL-----------LQELELAALPSLRLVLVGGEALPPDLVRRWREL 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 326 GarfkmPAECVFPAYGMAEATLAVSFAplftgltldvvEADALEAENRAVPVpegdprrgtdgvrsfallGRPLDGLEAE 405
Cdd:cd05930  232 L-----PGARLVNLYGPTEATVDATYY-----------RVPPDDEEDGRVPI------------------GRPIPNTRVY 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 406 IVDDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQ--------DEDGWL-NTGDLG-YLVDGQIVICGRRKD-VIIM 474
Cdd:cd05930  278 VLDENLRPVPPGVPGELYIGGAGLARGYL--NRPELTAerfvpnpfGPGERMyRTGDLVrWLPDGNLEFLGRIDDqVKIR 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 475 GGRnLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQvsarvRDAVDMRPYAVVVLP 554
Cdd:cd05930  356 GYR-IELGEIEAALLAHPGVREAAVVAREDGDGEKRLVAYVVPDEGGELDEEELRAHLAE-----RLPDYMVPSAFVVLD 429
                        410
                 ....*....|....*.
gi 300790052 555 AgsLPKTPSGKVKRAA 570
Cdd:cd05930  430 A--LPLTPNGKVDRKA 443
FACL_like_2 cd05917
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
183-568 3.99e-27

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341241 [Multi-domain]  Cd Length: 349  Bit Score: 112.76  E-value: 3.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 183 LQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEFLSGPL 262
Cdd:cd05917    7 IQFTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQ-DRLCIPVPLFHCFGSVLGVLACLTHGATMVFPSPSFDPLAVL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 263 --IWPELITKYHGTttaaPNFAYAIVGRrmarvDEDDAYDLSKLRIALNGAEPIDETAVQTFVDagarfKMPAECVFPAY 340
Cdd:cd05917   86 eaIEKEKCTALHGV----PTMFIAELEH-----PDFDKFDLSSLRTGIMAGAPCPPELMKRVIE-----VMNMKDVTIAY 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 341 GMAEATlavsfaPLFTGLTLDVveadalEAENRAVPVpegdprrgtdgvrsfallGRPLDGLEAEIVDDAGKRVDER-EV 419
Cdd:cd05917  152 GMTETS------PVSTQTRTDD------SIEKRVNTV------------------GRIMPHTEAKIVDPEGGIVPPVgVP 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 420 GEIRLRGEAVTPGYLTMdgPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIER--------A 487
Cdd:cd05917  202 GELCIRGYSVMKGYWND--PEKTAeaiDGDGWLHTGDLAVMdEDGYCRIVGRIKDMIIRGGENIYPREIEEflhthpkvS 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 488 ATSVEGV---RAGNAVA--VRLDAGSRRerfavvlesklagDAEAEKNLMKQVSARvrdavdmrpYAV--VVLPAGSLPK 560
Cdd:cd05917  280 DVQVVGVpdeRYGEEVCawIRLKEGAEL-------------TEEDIKAYCKGKIAH---------YKVprYVFFVDEFPL 337

                 ....*...
gi 300790052 561 TPSGKVKR 568
Cdd:cd05917  338 TVSGKIQK 345
AAS_C cd05909
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...
172-517 4.98e-27

C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.


Pssm-ID: 341235 [Multi-domain]  Cd Length: 490  Bit Score: 114.74  E-value: 4.98e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVk 251
Cdd:cd05909  141 VAPVQPDDPAVILFTSGSEGLPKGVVLSHKNLLANVEQITAIFDPNPE-DVVFGALPFFHSFGLTGCLWLPLLSGIKVV- 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 252 itpveFLSGPL---IWPELITKYHGTTT-AAPNFAYAIVGRRmarvdedDAYDLSKLRIALNGAEPIDETAVQTFVDaga 327
Cdd:cd05909  219 -----FHPNPLdykKIPELIYDKKATILlGTPTFLRGYARAA-------HPEDFSSLRLVVAGAEKLKDTLRQEFQE--- 283
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 328 RFKMPaecVFPAYGMAEAtlavsfAPLFtgltldvveadaleaenrAVPVPEGDPRRGTdgvrsfalLGRPLDGLEAEIV 407
Cdd:cd05909  284 KFGIR---ILEGYGTTEC------SPVI------------------SVNTPQSPNKEGT--------VGRPLPGMEVKIV 328
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDAGK-RVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIE 485
Cdd:cd05909  329 SVETHeEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAFGDGWYDTGDIGKIdGEGFLTITGRLSRFAKIAGEMVSLEAIE 408
                        330       340       350
                 ....*....|....*....|....*....|..
gi 300790052 486 RAATSVEGVRAGNAVAVRLDaGSRRERFAVVL 517
Cdd:cd05909  409 DILSEILPEDNEVAVVSVPD-GRKGEKIVLLT 439
LC_FACS_like cd17640
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ...
163-489 9.14e-27

Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341295 [Multi-domain]  Cd Length: 468  Bit Score: 113.61  E-value: 9.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 163 LAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDM--------- 233
Cdd:cd17640   73 LNHSESVALVVENDSDDLATIIYTSGTTGNPKGVMLTHANLLHQIRSLSDIVPPQPG-DRFLSILPIWHSYersaeyfif 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 234 --GMVGFLTVPMTFGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRrmarvdeddAYDLSKLRIALNGA 311
Cdd:cd17640  152 acGCSQAYTSIRTLKDDLKRVKPHYIVSVPRLWESLYSGIQKQVSKSSPIKQFLFLF---------FLSGGIFKFGISGG 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 312 EPIdETAVQTFVDA-GARfkmpaecVFPAYGMAEATLAVSFAPLftgltldvveadaleaenravpvpeGDPRRGTdgvr 390
Cdd:cd17640  223 GAL-PPHVDTFFEAiGIE-------VLNGYGLTETSPVVSARRL-------------------------KCNVRGS---- 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 391 sfalLGRPLDGLEAEIVDDAGKRVDER-EVGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYLV-DGQIVIC 465
Cdd:cd17640  266 ----VGRPLPGTEIKIVDPEGNVVLPPgEKGIVWVRGPQVMKGYY--KNPEATSkvlDSDGWFNTGDLGWLTcGGELVLT 339
                        330       340
                 ....*....|....*....|....*
gi 300790052 466 GRRKDVIIM-GGRNLYPTDIERAAT 489
Cdd:cd17640  340 GRAKDTIVLsNGENVEPQPIEEALM 364
BCL_like cd05919
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...
162-570 1.39e-26

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.


Pssm-ID: 341243 [Multi-domain]  Cd Length: 436  Bit Score: 112.56  E-value: 1.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 162 ELAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLTV 241
Cdd:cd05919   75 AYIARDCEARLVVTSADDIAYLLYSSGTTGPPKGVMHAHRDPLLFADAMAREALGLTPGDRVFSSAKMFFGYGLGNSLWF 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 242 PMTFGV-----------ELVKITPVEFlsGPLIWpelitkyhgttTAAPNFaYAivgrRMARVDEDDAYDLSKLRIALNG 310
Cdd:cd05919  155 PLAVGAsavlnpgwptaERVLATLARF--RPTVL-----------YGVPTF-YA----NLLDSCAGSPDALRSLRLCVSA 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 311 AEPIDEtavqtfvdagarfkmpaecvfpayGMAEATLAVSFAPLFTGLtlDVVEADALEAENRAvpvpeGDPRRGTdgvr 390
Cdd:cd05919  217 GEALPR------------------------GLGERWMEHFGGPILDGI--GATEVGHIFLSNRP-----GAWRLGS---- 261
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 391 sfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTM-DGPLATQdEDGWLNTGDL-GYLVDGQIVICGRR 468
Cdd:cd05919  262 ----TGRPVPGYEIRLVDEEGHTIPPGEEGDLLVRGPSAAVGYWNNpEKSRATF-NGGWYRTGDKfCRDADGWYTHAGRA 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 469 KDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVrdAVDMRPY 548
Cdd:cd05919  337 DDMLKVGGQWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPAAPQESLARDIHRHLLERL--SAHKVPR 414
                        410       420
                 ....*....|....*....|..
gi 300790052 549 AVVVLPAgsLPKTPSGKVKRAA 570
Cdd:cd05919  415 RIAFVDE--LPRTATGKLQRFK 434
MCS cd05941
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...
179-568 7.84e-26

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.


Pssm-ID: 341264 [Multi-domain]  Cd Length: 442  Bit Score: 110.46  E-value: 7.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVElvkitpVEFL 258
Cdd:cd05941   90 DPALILYTSGTTGRPKGVVLTHANLAANVRALVDAWRWTED-DVLLHVLPLHHVHGLVNALLCPLFAGAS------VEFL 162
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 SGPLIWPELITKYHGTTT---AAPNFaYAivgRRMARVDEDD-------AYDLSKLRIALNGAEPIDETAVQTFVDAGAR 328
Cdd:cd05941  163 PKFDPKEVAISRLMPSITvfmGVPTI-YT---RLLQYYEAHFtdpqfarAAAAERLRLMVSGSAALPVPTLEEWEAITGH 238
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 329 FkmpaecVFPAYGMAEATLAVSfAPLftgltldvveadaleaenravpvpEGDPRRGTdgvrsfalLGRPLDGLEAEIVD 408
Cdd:cd05941  239 T------LLERYGMTEIGMALS-NPL------------------------DGERRPGT--------VGMPLPGVQARIVD 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 409 D-AGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQDE---DGWLNTGDLG-YLVDGQIVICGRRKDVII-MGGRNLYPT 482
Cdd:cd05941  280 EeTGEPLPRGEVGEIQVRGPSVFKEYWNK--PEATKEEftdDGWFKTGDLGvVDEDGYYWILGRSSVDIIkSGGYKVSAL 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 483 DIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLES-KLAGDAEAEKNLMKQVSARVRdavdmRPYAVVVLPAgsLPKT 561
Cdd:cd05941  358 EIERVLLAHPGVSECAVIGVPDPDWGERVVAVVVLRAgAAALSLEELKEWAKQRLAPYK-----RPRRLILVDE--LPRN 430

                 ....*..
gi 300790052 562 PSGKVKR 568
Cdd:cd05941  431 AMGKVNK 437
FACL_like_6 cd05922
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
164-570 1.37e-25

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341246 [Multi-domain]  Cd Length: 457  Bit Score: 109.84  E-value: 1.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 164 AAAEPLPDVVVTDEgDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMvGFLTVPM 243
Cdd:cd05922  104 AARASAPAHEVSHE-DLALLLYTSGSTGSPKLVRLSHQNLLANARSIAEYLGITAD-DRALTVLPLSYDYGL-SVLNTHL 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 244 TFGVELVkITPvEFLSGPLIWpELITKYHGTTTAAPNFAYAIvgrrMARVDEDDAyDLSKLRIALNGAEPIDETAVQTFv 323
Cdd:cd05922  181 LRGATLV-LTN-DGVLDDAFW-EDLREHGATGLAGVPSTYAM----LTRLGFDPA-KLPSLRYLTQAGGRLPQETIARL- 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 324 dagaRFKMPAECVFPAYGMAEATLAVSFAPlftgltldvveadaleaenravpvPEGDPRRGTDgvrsfalLGRPLDGLE 403
Cdd:cd05922  252 ----RELLPGAQVYVMYGQTEATRRMTYLP------------------------PERILEKPGS-------IGLAIPGGE 296
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 404 AEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDE-DGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYP 481
Cdd:cd05922  297 FEILDDDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYRRKEGRgGGVLHTGDLARRdEDGFLFIVGRRDRMIKLFGNRISP 376
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 482 TDIERAATSVEGVRAGNAVAVRLDAGsrrERFAVVLESKLAGDAEAeknLMKQVSARVRDAvdMRPYAVVVLpaGSLPKT 561
Cdd:cd05922  377 TEIEAAARSIGLIIEAAAVGLPDPLG---EKLALFVTAPDKIDPKD---VLRSLAERLPPY--KVPATVRVV--DELPLT 446

                 ....*....
gi 300790052 562 PSGKVKRAA 570
Cdd:cd05922  447 ASGKVDYAA 455
Acs COG0365
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
24-568 6.62e-25

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];


Pssm-ID: 440134 [Multi-domain]  Cd Length: 565  Bit Score: 109.05  E-value: 6.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  24 GEPKEPVRRTWAEVHEEARRIAGGLVAGGFERG------------TAVGVLAAApvliapTVQAVWlaggSV--TMLhqp 89
Cdd:COG0365   32 GEDGEERTLTYAELRREVNRFANALRALGVKKGdrvaiylpnipeAVIAMLACA------RIGAVH----SPvfPGF--- 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  90 TPRtDLAEWAEDT-VRVLgmIGSDQDALGG-PGGLAPR----PGSGAGPRNVTVllgepFDQLAPVLEQKGIgFQLITEL 163
Cdd:COG0365   99 GAE-ALADRIEDAeAKVL--ITADGGLRGGkVIDLKEKvdeaLEELPSLEHVIV-----VGRTGADVPMEGD-LDWDELL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 164 AAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMverAEFDFDV---DVM-----VSWLptfhdMGM 235
Cdd:COG0365  170 AAASAEFEPEPTDADDPLFILYTSGTTGKPKGVVHTHGGYLVHAATT---AKYVLDLkpgDVFwctadIGWA-----TGH 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 236 VGFLTVPMTFGVELVkitpveFLSGPLIWP------ELITKYHGTTT-AAPNfAYaivgRRMARVDED--DAYDLSKLRI 306
Cdd:COG0365  242 SYIVYGPLLNGATVV------LYEGRPDFPdpgrlwELIEKYGVTVFfTAPT-AI----RALMKAGDEplKKYDLSSLRL 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 307 ALNGAEPIDETAVQTFVDAgarFKMPaecVFPAYGMAEATLAVsfaplftgltldvveadaleaenrAVPVPEGDPRRGT 386
Cdd:COG0365  311 LGSAGEPLNPEVWEWWYEA---VGVP---IVDGWGQTETGGIF------------------------ISNLPGLPVKPGS 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 387 dgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGE--AVTPGYLtmDGPLATQDE-----DGWLNTGDLGYL-V 458
Cdd:COG0365  361 --------MGKPVPGYDVAVVDEDGNPVPPGEEGELVIKGPwpGMFRGYW--NDPERYRETyfgrfPGWYRTGDGARRdE 430
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 459 DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRagNAVAV-RLDAGsRRER---FaVVLESKLAGDAEAEKNLMKQ 534
Cdd:COG0365  431 DGYFWILGRSDDVINVSGHRIGTAEIESALVSHPAVA--EAAVVgVPDEI-RGQVvkaF-VVLKPGVEPSDELAKELQAH 506
                        570       580       590
                 ....*....|....*....|....*....|....
gi 300790052 535 VSARVrdAVDMRPYAVVVLPAgsLPKTPSGKVKR 568
Cdd:COG0365  507 VREEL--GPYAYPREIEFVDE--LPKTRSGKIMR 536
A_NRPS_Cytc1-like cd17643
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...
170-570 1.65e-24

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341298 [Multi-domain]  Cd Length: 450  Bit Score: 106.62  E-value: 1.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDEGDTALLQLTSGSTADPKAVRITYGNlysnVKAMVERAEFDFDVDVMVSWLpTFHDMGM---VGFLTVPMTFG 246
Cdd:cd17643   85 PSLLLTDPDDLAYVIYTSGSTGRPKGVVVSHAN----VLALFAATQRWFGFNEDDVWT-LFHSYAFdfsVWEIWGALLHG 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 247 VELVKI------TPVEFLSgpLIWPELITKYHGTTTAapnFayaivgRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQ 320
Cdd:cd17643  160 GRLVVVpyevarSPEDFAR--LLRDEGVTVLNQTPSA---F------YQLVEAADRDGRDPLALRYVIFGGEALEAAMLR 228
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 321 TFVdagARFKMPAECVFPAYGMAEATLAVSFAPLftgltldvVEADALEAENravpvpegdprrgtdgvrsfALLGRPLD 400
Cdd:cd17643  229 PWA---GRFGLDRPQLVNMYGITETTVHVTFRPL--------DAADLPAAAA--------------------SPIGRPLP 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQ---DEDG-----WLNTGDLG-YLVDGQIVICGRRKDV 471
Cdd:cd17643  278 GLRVYVLDADGRPVPPGVVGELYVSGAGVARGYLGRPELTAERfvaNPFGgpgsrMYRTGDLArRLPDGELEYLGRADEQ 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 472 IIMGGRNLYPTDIERAATSVEGVRAGnAVAVRLDA-GSRRERFAVVLESKLAGDAEAEKNLMKqvsARVRDAvdMRPYAV 550
Cdd:cd17643  358 VKIRGFRIELGEIEAALATHPSVRDA-AVIVREDEpGDTRLVAYVVADDGAAADIAELRALLK---ELLPDY--MVPARY 431
                        410       420
                 ....*....|....*....|
gi 300790052 551 VVLPAgsLPKTPSGKVKRAA 570
Cdd:cd17643  432 VPLDA--LPLTVNGKLDRAA 449
BCL_4HBCL cd05959
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...
31-568 6.11e-23

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.


Pssm-ID: 341269 [Multi-domain]  Cd Length: 508  Bit Score: 102.45  E-value: 6.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  31 RRTWAEVHEEARRIAGGLVAGGFERGTAVG-VLAAAPVLIAPTVQAVwLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmi 109
Cdd:cd05959   29 SLTYAELEAEARRVAGALRALGVKREERVLlIMLDTVDFPTAFLGAI-RAGIVPVPVNTLLTPDDYAYYLED-------- 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 gSDQDALGGPGGLAPRPGS---GAGPRNVTVLLGEPFDQLAPVLeqkgigfQLITELAAAEPLPDVVVTDEGDTALLQLT 186
Cdd:cd05959  100 -SRARVVVVSGELAPVLAAaltKSEHTLVVLIVSGGAGPEAGAL-------LLAELVAAEAEQLKPAATHADDPAFWLYS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 187 SGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLTVPMTFGVELV----KITPVEFLsgpl 262
Cdd:cd05959  172 SGSTGRPKGVVHLHADIYWTAELYARNVLGIREDDVCFSAAKLFFAYGLGNSLTFPLSVGATTVlmpeRPTPAAVF---- 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 263 iwpELITKYHGTTT-AAPNFaYAivgrRMARVDEDDAYDLSKLRIALNGAEPIDEtavqtfvDAGARFKMpaecvfpayg 341
Cdd:cd05959  248 ---KRIRRYRPTVFfGVPTL-YA----AMLAAPNLPSRDLSSLRLCVSAGEALPA-------EVGERWKA---------- 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 342 maeatlavsfaplFTGLT-LDVV---EADALEAENRAvpvpeGDPRRGTDGvrsfallgRPLDGLEAEIVDDAGKRVDER 417
Cdd:cd05959  303 -------------RFGLDiLDGIgstEMLHIFLSNRP-----GRVRYGTTG--------KPVPGYEVELRDEDGGDVADG 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 418 EVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDlGYLV--DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVR 495
Cdd:cd05959  357 EPGELYVRGPSSATMYWNNRDKTRDTFQGEWTRTGD-KYVRddDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVL 435
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300790052 496 AGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLpaGSLPKTPSGKVKR 568
Cdd:cd05959  436 EAAVVGVEDEDGLTKPKAFVVLRPGYEDSEALEEELKEFVKDRL--APYKYPRWIVFV--DELPKTATGKIQR 504
OSB_MenE-like cd17630
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...
179-575 7.63e-23

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.


Pssm-ID: 341285 [Multi-domain]  Cd Length: 325  Bit Score: 99.71  E-value: 7.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSwLPTFHDMGMvGFLTVPMTFGVELVKITPVefl 258
Cdd:cd17630    1 RLATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGDSWLLS-LPLYHVGGL-AILVRSLLAGAELVLLERN--- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 sgpliWPELITKYHGTTTAApnfayAIVGRRMARVDEDDAY--DLSKLRIALNGAEPIDETAVQTFVDAGARfkmpaecV 336
Cdd:cd17630   76 -----QALAEDLAPPGVTHV-----SLVPTQLQRLLDSGQGpaALKSLRAVLLGGAPIPPELLERAADRGIP-------L 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 337 FPAYGMAEatlavsFAPLFTGLTLDvveadaleaenravpvpegDPRRGTDgvrsfallGRPLDGLEAEIVDDagkrvde 416
Cdd:cd17630  139 YTTYGMTE------TASQVATKRPD-------------------GFGRGGV--------GVLLPGRELRIVED------- 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 417 revGEIRLRGEAVTPGYLTMDGPLATqDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVR 495
Cdd:cd17630  179 ---GEIWVGGASLAMGYLRGQLVPEF-NEDGWFTTKDLGELhADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVR 254
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 496 AGNAVAVrldaGSRR--ERFAVVLESklagdaeAEKNLMKQVSARVRDAVD--MRPYAVVVLPAgsLPKTPSGKVKRAAT 571
Cdd:cd17630  255 DAFVVGV----PDEElgQRPVAVIVG-------RGPADPAELRAWLKDKLArfKLPKRIYPVPE--LPRTGGGKVDRRAL 321

                 ....
gi 300790052 572 AQQF 575
Cdd:cd17630  322 RAWL 325
ttLC_FACS_AEE21_like cd12118
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...
30-568 1.21e-22

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.


Pssm-ID: 341283 [Multi-domain]  Cd Length: 486  Bit Score: 101.22  E-value: 1.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  30 VRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGsvtmlhqptprtdlaewaedtvrVLGMI 109
Cdd:cd12118   28 RRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGA-----------------------VLNAL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 GSDQDAlggpgglaprpgsgagpRNVTVLLGEPFDQLAPVLEQkgigFQLITELAAAEPLPD-VVVTDEGDTALLQLTSG 188
Cdd:cd12118   85 NTRLDA-----------------EEIAFILRHSEAKVLFVDRE----FEYEDLLAEGDPDFEwIPPADEWDPIALNYTSG 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 189 STADPKAVRITYGNLYSNvkAMVERAEFDFDVDVMVSW-LPTFHDMGMVGFLTVPMTFG--VELVKITPveflsgPLIWp 265
Cdd:cd12118  144 TTGRPKGVVYHHRGAYLN--ALANILEWEMKQHPVYLWtLPMFHCNGWCFPWTVAAVGGtnVCLRKVDA------KAIY- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 266 ELITKYHGT-TTAAPnfayaIVGRRMARVDEDDAYDLS-KLRIALNGAEPidetavqtfvDAGARFKMPAE--CVFPAYG 341
Cdd:cd12118  215 DLIEKHKVThFCGAP-----TVLNMLANAPPSDARPLPhRVHVMTAGAPP----------PAAVLAKMEELgfDVTHVYG 279
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 342 MAEATLAVSFAPLFTgltldvvEADALEAENRAVpvpegdpRRGTDGVRSFALLgrPLDGLEAEIVDDAGKrvDEREVGE 421
Cdd:cd12118  280 LTETYGPATVCAWKP-------EWDELPTEERAR-------LKARQGVRYVGLE--EVDVLDPETMKPVPR--DGKTIGE 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 422 IRLRGEAVTPGYLtmDGPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGn 498
Cdd:cd12118  342 IVFRGNIVMKGYL--KNPEATAEafRGGWFHSGDLAVIhPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEA- 418
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300790052 499 AVAVRLDagsrrERFAVVLES--KLAGDAEA-EKNLMKQvsARVRDAVDMRPYAVVVLPagsLPKTPSGKVKR 568
Cdd:cd12118  419 AVVARPD-----EKWGEVPCAfvELKEGAKVtEEEIIAF--CREHLAGFMVPKTVVFGE---LPKTSTGKIQK 481
PRK06710 PRK06710
long-chain-fatty-acid--CoA ligase; Validated
171-584 2.56e-22

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 180666 [Multi-domain]  Cd Length: 563  Bit Score: 100.88  E-value: 2.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 171 DVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSN----VKAMVERAEFDfdvDVMVSWLPTFHDMGMVGFLTVPMTFG 246
Cdd:PRK06710 199 EVPCDPENDLALLQYTGGTTGFPKGVMLTHKNLVSNtlmgVQWLYNCKEGE---EVVLGVLPFFHVYGMTAVMNLSIMQG 275
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 247 VELVKITPVEFlsgPLIWpELITKYHGTT-TAAPNFAYAIVGRRMARvdeddAYDLSKLRIALNGAEPIDETAVQTF--V 323
Cdd:PRK06710 276 YKMVLIPKFDM---KMVF-EAIKKHKVTLfPGAPTIYIALLNSPLLK-----EYDISSIRACISGSAPLPVEVQEKFetV 346
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 324 DAGArfkmpaecVFPAYGMAEATlavsfaplftgltlDVVEADALeAENRavpVPegdprrGTDGVrsfallgrPLDGLE 403
Cdd:PRK06710 347 TGGK--------LVEGYGLTESS--------------PVTHSNFL-WEKR---VP------GSIGV--------PWPDTE 386
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 404 AEIVD-DAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYP 481
Cdd:PRK06710 387 AMIMSlETGEALPPGEIGEIVVKGPQIMKGYWNKPEETAAVLQDGWLHTGDVGYMdEDGFFYVKDRKKDMIVASGFNVYP 466
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 482 TDIERAATSVEGVRagNAVAVRLDAGSRRER---FAVVLESKLAGDAEAEKNLMKQVSA-RVRDAVDMRpyavvvlpaGS 557
Cdd:PRK06710 467 REVEEVLYEHEKVQ--EVVTIGVPDPYRGETvkaFVVLKEGTECSEEELNQFARKYLAAyKVPKVYEFR---------DE 535
                        410       420
                 ....*....|....*....|....*..
gi 300790052 558 LPKTPSGKVKRAATAQQfadRIKKNAD 584
Cdd:PRK06710 536 LPKTTVGKILRRVLIEE---EKRKNED 559
MACS_like cd05972
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...
172-570 3.50e-22

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.


Pssm-ID: 341276 [Multi-domain]  Cd Length: 428  Bit Score: 99.33  E-value: 3.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMvsWlpTFHDMGMVGFL----TVPMTFGV 247
Cdd:cd05972   75 AIVTDAEDPALIYFTSGTTGLPKGVLHTHSYPLGHIPTAAYWLGLRPD-DIH--W--NIADPGWAKGAwssfFGPWLLGA 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 248 ELVKITPVEFlsGPLIWPELITKYHGTTTAAPNFAYaivgRRMARVDEDdAYDLSKLRIALNGAEPIDETAVQTFVDAga 327
Cdd:cd05972  150 TVFVYEGPRF--DAERILELLERYGVTSFCGPPTAY----RMLIKQDLS-SYKFSHLRLVVSAGEPLNPEVIEWWRAA-- 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 328 rFKMPaecVFPAYGMAEatlavsfaplfTGLTLDVVeadaleaenRAVPVPEGDprrgtdgvrsfalLGRPLDGLEAEIV 407
Cdd:cd05972  221 -TGLP---IRDGYGQTE-----------TGLTVGNF---------PDMPVKPGS-------------MGRPTPGYDVAII 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDAGKRVDEREVGEIRLRGEAVTP--GYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDI 484
Cdd:cd05972  264 DDDGRELPPGEEGDIAIKLPPPGLflGYVGDPEKTEASIRGDYYLTGDRAYRdEDGYFWFVGRADDIIKSSGYRIGPFEV 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 485 ERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESklagDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLPKTPSG 564
Cdd:cd05972  344 ESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTS----GYEPSEELAEELQGHVKKVLAPYKYPREIEFVEELPKTISG 419

                 ....*.
gi 300790052 565 KVKRAA 570
Cdd:cd05972  420 KIRRVE 425
FadD3 cd17638
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...
179-568 3.02e-21

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.


Pssm-ID: 341293 [Multi-domain]  Cd Length: 330  Bit Score: 94.88  E-value: 3.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVkitPVEFL 258
Cdd:cd17638    1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTED-DRYLIINPFFHTFGYKAGIVACLLTGATVV---PVAVF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 SGPLIWPELITKYHGTTTAAPNFAYAIVGrrmarVDEDDAYDLSKLRIALNGAEPIDETAVQTFvdagaRFKMPAECVFP 338
Cdd:cd17638   77 DVDAILEAIERERITVLPGPPTLFQSLLD-----HPGRKKFDLSSLRAAVTGAATVPVELVRRM-----RSELGFETVLT 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 339 AYGMAEATLAVSFAPlftgltldvveadaleaenravpvpegdprrGTDGVRSFALLGRPLDGLEAEIVDDagkrvdere 418
Cdd:cd17638  147 AYGLTEAGVATMCRP-------------------------------GDDAETVATTCGRACPGFEVRIADD--------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 419 vGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYLVD-GQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGV 494
Cdd:cd17638  187 -GEVLVRGYNVMQGYL--DDPEATAeaiDADGWLHTGDVGELDErGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGV 263
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300790052 495 RAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAeknlmkqVSARVRDavDMRPYAV--VVLPAGSLPKTPSGKVKR 568
Cdd:cd17638  264 AQVAVIGVPDERMGEVGKAFVVARPGVTLTEED-------VIAWCRE--RLANYKVprFVRFLDELPRNASGKVMK 330
LC_FACS_like cd05935
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...
172-568 3.52e-21

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.


Pssm-ID: 341258 [Multi-domain]  Cd Length: 430  Bit Score: 96.39  E-value: 3.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVK 251
Cdd:cd05935   78 VVGSELDDLALIPYTSGTTGLPKGCMHTHFSAAANALQSAVWTGLTPS-DVILACLPLFHVTGFVGSLNTAVYVGGTYVL 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 252 ITpveflsgplIW-----PELITKYHGT-TTAAPnfayAIVGRRMARVdEDDAYDLSKLRIALNGAEPIDETAVQTFVD- 324
Cdd:cd05935  157 MA---------RWdretaLELIEKYKVTfWTNIP----TMLVDLLATP-EFKTRDLSSLKVLTGGGAPMPPAVAEKLLKl 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 325 AGARFkmpaecvFPAYGMAEAtlavsFAPLFTGltldvveadaleaenravpvPEGDPRRGTdgvrsfalLGRPLDGLEA 404
Cdd:cd05935  223 TGLRF-------VEGYGLTET-----MSQTHTN--------------------PPLRPKLQC--------LGIP*FGVDA 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 405 EIVD-DAGKRVDEREVGEIRLRGEAVTPGYltMDGPLATQD---EDG---WLNTGDLGYL-VDGQIVICGRRKDVIIMGG 476
Cdd:cd05935  263 RVIDiETGRELPPNEVGEIVVRGPQIFKGY--WNRPEETEEsfiEIKgrrFFRTGDLGYMdEEGYFFFVDRVKRMINVSG 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 477 RNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEkNLMKQvsARVRDAVDMRPYAVVVLPag 556
Cdd:cd05935  341 FKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLRPEYRGKVTEE-DIIEW--AREQMAAYKYPREVEFVD-- 415
                        410
                 ....*....|..
gi 300790052 557 SLPKTPSGKVKR 568
Cdd:cd05935  416 ELPRSASGKILW 427
PLN02330 PLN02330
4-coumarate--CoA ligase-like 1
33-582 5.22e-21

4-coumarate--CoA ligase-like 1


Pssm-ID: 215189 [Multi-domain]  Cd Length: 546  Bit Score: 96.59  E-value: 5.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEdTVRVLGMIGSD 112
Cdd:PLN02330  57 TYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAE-AAGAKLIVTND 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 QD-----ALGGPgglaprpgsgagprnvTVLLGEpfDQLAPVLEQKGIgfqliteLAAAEPLPDVVVTDE---GDTALLQ 184
Cdd:PLN02330 136 TNygkvkGLGLP----------------VIVLGE--EKIEGAVNWKEL-------LEAADRAGDTSDNEEilqTDLCALP 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 185 LTSGSTADPKAVRITYGNLYSNVKAMV--ERAEFDFDVdVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVE---FLS 259
Cdd:PLN02330 191 FSSGTTGISKGVMLTHRNLVANLCSSLfsVGPEMIGQV-VTLGLIPFFHIYGITGICCATLRNKGKVVVMSRFElrtFLN 269
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 260 GpliwpeLITKYHGTTTAAPNFAYAIVGRRMarVDEddaYDLSKLRI--ALNGAEPIDETAVQTFVDagarfKMPAECVF 337
Cdd:PLN02330 270 A------LITQEVSFAPIVPPIILNLVKNPI--VEE---FDLSKLKLqaIMTAAAPLAPELLTAFEA-----KFPGVQVQ 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 338 PAYGMAEatlavsfaplftgltldvveadaleaeNRAVPVPEGDPRRGtDGVRSFALLGRPLDGLEAEIVD-DAGKRVDE 416
Cdd:PLN02330 334 EAYGLTE---------------------------HSCITLTHGDPEKG-HGIAKKNSVGFILPNLEVKFIDpDTGRSLPK 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 417 REVGEIRLRGEAVTPGYLTMDGPLA-TQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIER---AATSV 491
Cdd:PLN02330 386 NTPGELCVRSQCVMQGYYNNKEETDrTIDEDGWLHTGDIGYIdDDGDIFIVDRIKELIKYKGFQVAPAELEAillTHPSV 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 492 EGVragnAVAVRLDAGSRRERFAVVLESKLAgdAEAEKNLMKQVSARVRDAVDMRpyavVVLPAGSLPKTPSGKVKRAAT 571
Cdd:PLN02330 466 EDA----AVVPLPDEEAGEIPAACVVINPKA--KESEEDILNFVAANVAHYKKVR----VVQFVDSIPKSLSGKIMRRLL 535
                        570
                 ....*....|.
gi 300790052 572 AQQFADRIKKN 582
Cdd:PLN02330 536 KEKMLSINKAN 546
PRK05852 PRK05852
fatty acid--CoA ligase family protein;
2-578 5.89e-21

fatty acid--CoA ligase family protein;


Pssm-ID: 235625 [Multi-domain]  Cd Length: 534  Bit Score: 96.49  E-value: 5.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   2 SRFVDTLVATATKRGQQRGMVTGEPKEPVrrTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGG 81
Cdd:PRK05852  16 PRIADLVEVAATRLPEAPALVVTADRIAI--SYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  82 SVTMLHQPTPRTDLAewaeDTVRVLGMIGSDQDALGgPGGLAPrPGSGAGPRNVTVllgepfdqlAPVLEQKGiGFQLIT 161
Cdd:PRK05852  94 VVVPLDPALPIAEQR----VRSQAAGARVVLIDADG-PHDRAE-PTTRWWPLTVNV---------GGDSGPSG-GTLSVH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 162 ELAAAEPLPdVVVTDEG---DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHDMGMVGF 238
Cdd:PRK05852 158 LDAATEPTP-ATSTPEGlrpDDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLS-PRDATVAVMPLYHGHGLIAA 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 239 LTVPMTFGVELVKITPVEFlSGPLIWPELITKYHGTTTAAPNFaYAIVGRRMArvDEDDAYDLSKLRIALNGAEPIDETA 318
Cdd:PRK05852 236 LLATLASGGAVLLPARGRF-SAHTFWDDIKAVGATWYTAVPTI-HQILLERAA--TEPSGRKPAALRFIRSCSAPLTAET 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 319 VQTFVDagaRFKMPAECvfpAYGMAEATLAVSfaplftglTLDVVEADaleaenravpvpegdprRGTDGVRSFALLGRP 398
Cdd:PRK05852 312 AQALQT---EFAAPVVC---AFGMTEATHQVT--------TTQIEGIG-----------------QTENPVVSTGLVGRS 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 399 lDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGR 477
Cdd:PRK05852 361 -TGAQIRIVGSDGLPLPAGAVGEVWLRGTTVVRGYLGDPTITAANFTDGWLRTGDLGSLsAAGDLSIRGRIKELINRGGE 439
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 478 NLYPTDIERAATSVEGVRAgNAVAVRLDAGSRRERFAVVLESKLAGDAEAEknlmkqVSARVRDAVDMRPYAVVVLPAGS 557
Cdd:PRK05852 440 KISPERVEGVLASHPNVME-AAVFGVPDQLYGEAVAAVIVPRESAPPTAEE------LVQFCRERLAAFEIPASFQEASG 512
                        570       580
                 ....*....|....*....|.
gi 300790052 558 LPKTPSGKVKRAATAQQFADR 578
Cdd:PRK05852 513 LPHTAKGSLDRRAVAEQFGHS 533
PLN02246 PLN02246
4-coumarate--CoA ligase
160-568 7.37e-21

4-coumarate--CoA ligase


Pssm-ID: 215137 [Multi-domain]  Cd Length: 537  Bit Score: 96.20  E-value: 7.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 160 ITELAAA--EPLPDVVVTDEgDTALLQLTSGSTADPKAVRITYGNLYSNVKAMV--ERAEFDFDV-DVMVSWLPTFHDMG 234
Cdd:PLN02246 160 FSELTQAdeNELPEVEISPD-DVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVdgENPNLYFHSdDVILCVLPMFHIYS 238
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 235 MVGFLTVPMTFGVELVkITPvEFLSGPLIwpELITKYHgtTTAAPnFAYAIVgRRMARVDEDDAYDLSKLRIALNGAEPI 314
Cdd:PLN02246 239 LNSVLLCGLRVGAAIL-IMP-KFEIGALL--ELIQRHK--VTIAP-FVPPIV-LAIAKSPVVEKYDLSSIRMVLSGAAPL 310
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 315 DETAVQTFvdagaRFKMPAECVFPAYGMAEATLAVSFAPLFtgltldvveadALEaenravPVPegdprrgtdgVRSFAl 394
Cdd:PLN02246 311 GKELEDAF-----RAKLPNAVLGQGYGMTEAGPVLAMCLAF-----------AKE------PFP----------VKSGS- 357
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVD-DAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRK 469
Cdd:PLN02246 358 CGTVVRNAELKIVDpETGASLPRNQPGEICIRGPQIMKGYL--NDPEATAntiDKDGWLHTGDIGYIdDDDELFIVDRLK 435
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 470 DVIIMGGRNLYPTDIERAATSVEGVrAGNAVAVRLD--AGSRRERFAVVLE-SKLAGDaEAEKNLMKQV--SARVRDavd 544
Cdd:PLN02246 436 ELIKYKGFQVAPAELEALLISHPSI-ADAAVVPMKDevAGEVPVAFVVRSNgSEITED-EIKQFVAKQVvfYKRIHK--- 510
                        410       420
                 ....*....|....*....|....
gi 300790052 545 mrpyavvVLPAGSLPKTPSGKVKR 568
Cdd:PLN02246 511 -------VFFVDSIPKAPSGKILR 527
Firefly_Luc cd17642
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...
170-568 7.99e-21

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341297 [Multi-domain]  Cd Length: 532  Bit Score: 96.06  E-value: 7.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDEgDTALLQLTSGSTADPKAVRITYGNL---YSNVKAMVERAEFDFDVDVMvSWLPTFHDMGMVGFLTVpMTFG 246
Cdd:cd17642  177 PPSFDRDE-QVALIMNSSGSTGLPKGVQLTHKNIvarFSHARDPIFGNQIIPDTAIL-TVIPFHHGFGMFTTLGY-LICG 253
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 247 VELVKITPVE---FLSGpliwpelITKYHGTTT--AAPNFAYaivgrrMARVDEDDAYDLSKLRIALNGAEPID-ETAVQ 320
Cdd:cd17642  254 FRVVLMYKFEeelFLRS-------LQDYKVQSAllVPTLFAF------FAKSTLVDKYDLSNLHEIASGGAPLSkEVGEA 320
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 321 TfvdaGARFKMPAecVFPAYGMAEATLAVsfapLFTgltldvveadaleaenravpvPEGDPRRGTdgvrsfalLGRPLD 400
Cdd:cd17642  321 V----AKRFKLPG--IRQGYGLTETTSAI----LIT---------------------PEGDDKPGA--------VGKVVP 361
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 401 GLEAEIVD-DAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMG 475
Cdd:cd17642  362 FFYAKVVDlDTGKTLGPNERGELCVKGPMIMKGYV--NNPEATKaliDKDGWLHSGDIAYYdEDGHFFIVDRLKSLIKYK 439
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 476 GRNLYPTDIERAATSVEGVR-AGNAVAVRLDAGSRRERFaVVLEsklAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVlp 554
Cdd:cd17642  440 GYQVPPAELESILLQHPKIFdAGVAGIPDEDAGELPAAV-VVLE---AGKTMTEKEVMDYVASQVSTAKRLRGGVKFV-- 513
                        410
                 ....*....|....
gi 300790052 555 aGSLPKTPSGKVKR 568
Cdd:cd17642  514 -DEVPKGLTGKIDR 526
LC_FACS_bac cd05932
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...
33-568 3.06e-20

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341255 [Multi-domain]  Cd Length: 508  Bit Score: 94.07  E-value: 3.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGG-SVTMLHQPTPRT--DLAEWAEDTVRVLGMI 109
Cdd:cd05932    8 TWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHiSVPLYPTLNPDTirYVLEHSESKALFVGKL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 GSDQD-ALGGPGGLAPRPGSGAGPRNVTvllgEPFDQLapvleqkgigfqliteLAAAEPLPDVVVTDEGDTALLQLTSG 188
Cdd:cd05932   88 DDWKAmAPGVPEGLISISLPPPSAANCQ----YQWDDL----------------IAQHPPLEERPTRFPEQLATLIYTSG 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 189 STADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFH-------DMG------MVGFLTVPMTFGVELVKITPV 255
Cdd:cd05932  148 TTGQPKGVMLTFGSFAWAAQAGIEHIGTEEN-DRMLSYLPLAHvtervfvEGGslyggvLVAFAESLDTFVEDVQRARPT 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 256 EFLSGPLIWpeliTKY-HGTTTAAPN----------FAYAIVGRRMArvdedDAYDLSKLRIALNGAEPIDETAVQTFVD 324
Cdd:cd05932  227 LFFSVPRLW----TKFqQGVQDKIPQqklnlllkipVVNSLVKRKVL-----KGLGLDQCRLAGCGSAPVPPALLEWYRS 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 325 AGARfkmpaecVFPAYGMAEaTLAVSFaplftgltldvveadaleaenraVPVPeGDPRRGTdgvrsfalLGRPLDGLEA 404
Cdd:cd05932  298 LGLN-------ILEAYGMTE-NFAYSH-----------------------LNYP-GRDKIGT--------VGNAGPGVEV 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 405 EIVDDagkrvderevGEIRLRGEAVTPGYLTmdGPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMG-GRNL 479
Cdd:cd05932  338 RISED----------GEILVRSPALMMGYYK--DPEATAeafTADGFLRTGDKGELdADGNLTITGRVKDIFKTSkGKYV 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 480 YPTDIERAATSVEGVRAgnavAVRLDAGSRRERFAVVL--ESKLAGDAEAEKNL---MKQVSARVRDAVDMRP---YAVV 551
Cdd:cd05932  406 APAPIENKLAEHDRVEM----VCVIGSGLPAPLALVVLseEARLRADAFARAELeasLRAHLARVNSTLDSHEqlaGIVV 481
                        570       580
                 ....*....|....*....|
gi 300790052 552 VLPAGSLPK---TPSGKVKR 568
Cdd:cd05932  482 VKDPWSIDNgilTPTLKIKR 501
PRK05677 PRK05677
long-chain-fatty-acid--CoA ligase; Validated
153-568 3.36e-20

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 168170 [Multi-domain]  Cd Length: 562  Bit Score: 94.44  E-value: 3.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 153 KGIGFQLITELAAAEPLPDVVVtDEGDTALLQLTSGSTADPKAVRITYGNLYSN---VKAMVErAEFDFDVDVMVSWLP- 228
Cdd:PRK05677 183 QAVKFNDALAKGAGQPVTEANP-QADDVAVLQYTGGTTGVAKGAMLTHRNLVANmlqCRALMG-SNLNEGCEILIAPLPl 260
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 229 ------TFHDMGMvgfltvpMTFGVELVKItpveflSGPLIWPELI-----TKYHGTTTAAPNFAyAIVGRRMARvdedd 297
Cdd:PRK05677 261 yhiyafTFHCMAM-------MLIGNHNILI------SNPRDLPAMVkelgkWKFSGFVGLNTLFV-ALCNNEAFR----- 321
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 298 AYDLSKLRIALNGAepideTAVQTfvDAGARFKMPAEC-VFPAYGMAEATLAVSFAPLftgltldvveadaleaenravp 376
Cdd:PRK05677 322 KLDFSALKLTLSGG-----MALQL--ATAERWKEVTGCaICEGYGMTETSPVVSVNPS---------------------- 372
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 377 vpeGDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQ---DEDGWLNTGD 453
Cdd:PRK05677 373 ---QAIQVGT--------IGIPVPSTLCKVIDDDGNELPLGEVGELCVKGPQVMKGYWQR--PEATDeilDSDGWLKTGD 439
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 454 LGYLV-DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLM 532
Cdd:PRK05677 440 IALIQeDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQCAAIGVPDEKSGEAIKVFVVVKPGETLTKEQVMEHM 519
                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 300790052 533 K-QVSA-RVRDAVDMRpyavvvlpaGSLPKTPSGKVKR 568
Cdd:PRK05677 520 RaNLTGyKVPKAVEFR---------DELPTTNVGKILR 548
PRK07514 PRK07514
malonyl-CoA synthase; Validated
130-577 5.14e-20

malonyl-CoA synthase; Validated


Pssm-ID: 181011 [Multi-domain]  Cd Length: 504  Bit Score: 93.40  E-value: 5.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 130 AGPRnVTVLLGEPFDQLAPVLEQKGIG--FQL-------ITELAAAEPLP-DVVVTDEGDTALLQLTSGSTADPKAVRIT 199
Cdd:PRK07514  99 AEPA-LVVCDPANFAWLSKIAAAAGAPhvETLdadgtgsLLEAAAAAPDDfETVPRGADDLAAILYTSGTTGRSKGAMLS 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 200 YGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMvgfltvpmtfgveLVKITPVEFLSGPLIW-----PELITKYHGT 274
Cdd:PRK07514 178 HGNLLSNALTLVDYWRFTPD-DVLIHALPIFHTHGL-------------FVATNVALLAGASMIFlpkfdPDAVLALMPR 243
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 275 TTA---APNFaYAivgrRM---ARVDEDDAydlSKLRIALNGAEPIdetAVQTFVDAGARfkmPAECVFPAYGMAEATLA 348
Cdd:PRK07514 244 ATVmmgVPTF-YT----RLlqePRLTREAA---AHMRLFISGSAPL---LAETHREFQER---TGHAILERYGMTETNMN 309
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 349 VSfAPLftgltldvveadaleaenravpvpEGDPRRGTdgvrsfalLGRPLDGLEAEIVD-DAGKRVDEREVGEIRLRGE 427
Cdd:PRK07514 310 TS-NPY------------------------DGERRAGT--------VGFPLPGVSLRVTDpETGAELPPGEIGMIEVKGP 356
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 428 AVTPGYLTMdgPLATQDE---DGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVR-------- 495
Cdd:PRK07514 357 NVFKGYWRM--PEKTAEEfraDGFFITGDLGKIdERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVesavigvp 434
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 496 ------AGNAVAVRLDAGSRRERfAVV--LESKLAGdaeaeknlMKQvsarvrdavdmrPYAVVVLPAgsLPKTPSGKVK 567
Cdd:PRK07514 435 hpdfgeGVTAVVVPKPGAALDEA-AILaaLKGRLAR--------FKQ------------PKRVFFVDE--LPRNTMGKVQ 491
                        490
                 ....*....|
gi 300790052 568 RAATAQQFAD 577
Cdd:PRK07514 492 KNLLREQYAD 501
FADD10 cd17635
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...
179-568 8.52e-20

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.


Pssm-ID: 341290 [Multi-domain]  Cd Length: 340  Bit Score: 90.78  E-value: 8.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLTVPMTFGVelvKITPVEFL 258
Cdd:cd17635    2 DPLAVIFTSGTTGEPKAVLLANKTFFAVPDILQKEGLNWVVGDVTYLPLPATHIGGLWWILTCLIHGGL---CVTGGENT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 SGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEddaydLSKLRIALNGAEPIDETAVQTFVdagarfKMPAECVFP 338
Cdd:cd17635   79 TYKSLFKILTTNAVTTTCLVPTLLSKLVSELKSANAT-----VPSLRLIGYGGSRAIAADVRFIE------ATGLTNTAQ 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 339 AYGMAEATLAvsfapLFTGLTLDVVEADALeaenravpvpegdprrgtdgvrsfallGRPLDGLEAEIVDDAGKRVDERE 418
Cdd:cd17635  148 VYGLSETGTA-----LCLPTDDDSIEINAV---------------------------GRPYPGVDVYLAATDGIAGPSAS 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 419 VGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLV-DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAG 497
Cdd:cd17635  196 FGTIWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLGERReDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQEC 275
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300790052 498 nAVAVRLDagsrrERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVD--MRPYAVVVLPagSLPKTPSGKVKR 568
Cdd:cd17635  276 -ACYEISD-----EEFGELVGLAVVASAELDENAIRALKHTIRRELEpyARPSTIVIVT--DIPRTQSGKVKR 340
PRK06145 PRK06145
acyl-CoA synthetase; Validated
33-566 4.08e-19

acyl-CoA synthetase; Validated


Pssm-ID: 102207 [Multi-domain]  Cd Length: 497  Bit Score: 90.72  E-value: 4.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDTVRVLGMIGSD 112
Cdd:PRK06145  29 SYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVAYILGDAGAKLLLVDEE 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 QDALggPGGLAPRPGSGAGPRNVTVLLGEPfdqlapvleqkgigfqlitelaaAEPLPDVVVTDEGDTALLQLTSGSTAD 192
Cdd:PRK06145 109 FDAI--VALETPKIVIDAAAQADSRRLAQG-----------------------GLEIPPQAAVAPTDLVRLMYTSGTTDR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 193 PKAVRITYGNLY----SNVKAMVERAEFDFDV-----DVMVSWLPTFHDMGMVGFLTVPMTFGVELV-KITPVEFLSGPL 262
Cdd:PRK06145 164 PKGVMHSYGNLHwksiDHVIALGLTASERLLVvgplyHVGAFDLPGIAVLWVGGTLRIHREFDPEAVlAAIERHRLTCAW 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 263 IWPELITkyhgtttaapnfayaivgrRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTF--VDAGARFkmpaecvFPAY 340
Cdd:PRK06145 244 MAPVMLS-------------------RVLTVPDRDRFDLDSLAWCIGGGEKTPESRIRDFtrVFTRARY-------IDAY 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 341 GMAEAtlavsfaplftgltldvVEADALEAENRAVpvpegdprrgtDGVRSfalLGRPLDGLEAEIVDDAGKRVDEREVG 420
Cdd:PRK06145 298 GLTET-----------------CSGDTLMEAGREI-----------EKIGS---TGRALAHVEIRIADGAGRWLPPNMKG 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 421 EIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYLVD-GQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNA 499
Cdd:PRK06145 347 EICMRGPKVTKGYWKDPEKTAEAFYGDWFRSGDVGYLDEeGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAV 426
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300790052 500 VAVRLDAGSRRERFAVVLEsklAGDAEAEKNLMKQVSARVRDAVDMRPYAVVvlpaGSLPKTPSGKV 566
Cdd:PRK06145 427 IGVHDDRWGERITAVVVLN---PGATLTLEALDRHCRQRLASFKVPRQLKVR----DELPRNPSGKV 486
PRK08316 PRK08316
acyl-CoA synthetase; Validated
30-568 4.15e-19

acyl-CoA synthetase; Validated


Pssm-ID: 181381 [Multi-domain]  Cd Length: 523  Bit Score: 90.76  E-value: 4.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  30 VRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLA---AAPVLiaptvqaVWLAGGSVTMLHQPTprtDLAEWAEDTVRVL 106
Cdd:PRK08316  35 RSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGhnsDAYAL-------LWLACARAGAVHVPV---NFMLTGEELAYIL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 107 GMIGSDqdALGGPGGLAPRPGSGAGPRNVTVLLGEPFDQLAPVleqkGIGFQLITELAAAEP--LPDVVVTDEgDTALLQ 184
Cdd:PRK08316 105 DHSGAR--AFLVDPALAPTAEAALALLPVDTLILSLVLGGREA----PGGWLDFADWAEAGSvaEPDVELADD-DLAQIL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 185 LTSGSTADPKAVRITYGNLYSN-VKAMVErAEFDFDvDVMVSWLPTFHDMGMVGFLtvpMTF------GVELVKITPVEF 257
Cdd:PRK08316 178 YTSGTESLPKGAMLTHRALIAEyVSCIVA-GDMSAD-DIPLHALPLYHCAQLDVFL---GPYlyvgatNVILDAPDPELI 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 258 LsgPLIWPELITKYhgtttaapnFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFvdagaRFKMPAECVF 337
Cdd:PRK08316 253 L--RTIEAERITSF---------FAPPTVWISLLRHPDFDTRDLSSLRKGYYGASIMPVEVLKEL-----RERLPGLRFY 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 338 PAYGMAEatlavsFAPLFTGLTldvveadaleaenravpvPEGDPRRGTDGvrsfallGRPLDGLEAEIVDDAGKRVDER 417
Cdd:PRK08316 317 NCYGQTE------IAPLATVLG------------------PEEHLRRPGSA-------GRPVLNVETRVVDDDGNDVAPG 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 418 EVGEIRLRGEAVTPGYLtmDGPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGV 494
Cdd:PRK08316 366 EVGEIVHRSPQLMLGYW--DDPEKTAEafRGGWFHSGDLGVMdEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAV 443
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 495 ragNAVAVrldAGSRRERF------AVVLEsklAGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLPagSLPKTPSGKV-K 567
Cdd:PRK08316 444 ---AEVAV---IGLPDPKWieavtaVVVPK---AGATVTEDELIAHCRARL--AGFKVPKRVIFVD--ELPRNPSGKIlK 510

                 .
gi 300790052 568 R 568
Cdd:PRK08316 511 R 511
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
163-585 4.86e-19

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 91.57  E-value: 4.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  163 LAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVP 242
Cdd:PRK06814  778 LAGRFPLVYFCNRDPDDPAVILFTSGSEGTPKGVVLSHRNLLANRAQVAARIDFSPE-DKVFNALPVFHSFGLTGGLVLP 856
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  243 MTFGVelvkitPVEFLSGPL---IWPELI-----TKYHGTTTAAPNFAyaivgrRMArvdedDAYDLSKLRIALNGAEPI 314
Cdd:PRK06814  857 LLSGV------KVFLYPSPLhyrIIPELIydtnaTILFGTDTFLNGYA------RYA-----HPYDFRSLRYVFAGAEKV 919
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  315 DETAVQTFVDA-GARfkmpaecVFPAYGMAEAT--LAVSfAPLFtgltldvveadaleaeNRAvpvpegdprrGTdgvrs 391
Cdd:PRK06814  920 KEETRQTWMEKfGIR-------ILEGYGVTETApvIALN-TPMH----------------NKA----------GT----- 960
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  392 falLGRPLDGLEAEIVDDAGkrVDERevGEIRLRGEAVTPGYLTMDGPLATQD-EDGWLNTGDlgyLV----DGQIVICG 466
Cdd:PRK06814  961 ---VGRLLPGIEYRLEPVPG--IDEG--GRLFVRGPNVMLGYLRAENPGVLEPpADGWYDTGD---IVtideEGFITIKG 1030
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  467 RRKDVIIMGGRNLYPTDIERAATSVEgVRAGNAVAVRLDAgSRRERFAVVLESKlagDAEAEkNLMKQVSArvRDAVD-M 545
Cdd:PRK06814 1031 RAKRFAKIAGEMISLAAVEELAAELW-PDALHAAVSIPDA-RKGERIILLTTAS---DATRA-AFLAHAKA--AGASElM 1102
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 300790052  546 RPYAVVVLPAgsLPKTPSGKVKRAATAQQFADRIKKNADA 585
Cdd:PRK06814 1103 VPAEIITIDE--IPLLGTGKIDYVAVTKLAEEAAAKPEAA 1140
FACL_like_1 cd05910
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
148-541 4.92e-19

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341236 [Multi-domain]  Cd Length: 457  Bit Score: 90.21  E-value: 4.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 148 PVLEQKGIGFQ-LITELAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEF-DFDVDvmvs 225
Cdd:cd05910   54 PVLIDPGMGRKnLKQCLQEAEPDAFIGIPKADEPAAILFTSGSTGTPKGVVYRHGTFAAQIDALRQLYGIrPGEVD---- 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 226 wLPTFHDMGMVGFLtvpmtFGVELVkITPVEFL----SGPLIWPELITKYHGTTTaapnFAYAIVGRRMARVDEDDAYDL 301
Cdd:cd05910  130 -LATFPLFALFGPA-----LGLTSV-IPDMDPTrparADPQKLVGAIRQYGVSIV----FGSPALLERVARYCAQHGITL 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 302 SKLRIALNGAEPIDETAVQTFvdagARFKMPAECVFPAYGMAEAtlavsfaplftgLTLDVVEADALEAENRAVPvpegD 381
Cdd:cd05910  199 PSLRRVLSAGAPVPIALAARL----RKMLSDEAEILTPYGATEA------------LPVSSIGSRELLATTTAAT----S 258
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 382 PRRGTdgvrsfaLLGRPLDGLEAEIV--DDAG-------KRVDEREVGEIRLRGEAVTPGYLTMdgPLAT-----QDEDG 447
Cdd:cd05910  259 GGAGT-------CVGRPIPGVRVRIIeiDDEPiaewddtLELPRGEIGEITVTGPTVTPTYVNR--PVATalakiDDNSE 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 448 --WLNTGDLGYLVD-GQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVrldaGSRRERFAVVLESKLAGD 524
Cdd:cd05910  330 gfWHRMGDLGYLDDeGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV----GKPGCQLPVLCVEPLPGT 405
                        410
                 ....*....|....*..
gi 300790052 525 AEAEKNLMKQVSARVRD 541
Cdd:cd05910  406 ITPRARLEQELRALAKD 422
PRK06188 PRK06188
acyl-CoA synthetase; Validated
7-575 7.90e-19

acyl-CoA synthetase; Validated


Pssm-ID: 235731 [Multi-domain]  Cd Length: 524  Bit Score: 89.66  E-value: 7.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   7 TLVATATKRGQQR-GMVTGEpkepVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAA--APVLIAptVQAVWLAGGSV 83
Cdd:PRK06188  16 HLLVSALKRYPDRpALVLGD----TRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLnrPEVLMA--IGAAQLAGLRR 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  84 TMLHQPTPRTDLAEWAEDT-VRVLgmigsdqdaLGGPGGLAPRPGS-GAGPRNVTVLLGepfdqLAPVleqkGIGFQLIT 161
Cdd:PRK06188  90 TALHPLGSLDDHAYVLEDAgISTL---------IVDPAPFVERALAlLARVPSLKHVLT-----LGPV----PDGVDLLA 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 162 ELAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVerAEFDFDVDVMvswlptfhdmgmvgFLTV 241
Cdd:PRK06188 152 AAAKFGPAPLVAAALPPDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQL--AEWEWPADPR--------------FLMC 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 242 pmtfgvelvkiTPVEFLSGPLIWPELITKyhGTTTAAPNFAYAIVGRRMAR----------------VDEDD--AYDLSK 303
Cdd:PRK06188 216 -----------TPLSHAGGAFFLPTLLRG--GTVIVLAKFDPAEVLRAIEEqritatflvptmiyalLDHPDlrTRDLSS 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 304 LRIALNGAEPIDETAVQtfvDAGARFkmpAECVFPAYGMAEATLAVSfaplftglTLDVVEADAleaenravpvpeGDPR 383
Cdd:PRK06188 283 LETVYYGASPMSPVRLA---EAIERF---GPIFAQYYGQTEAPMVIT--------YLRKRDHDP------------DDPK 336
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 384 RgtdgvrsFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQD--EDGWLNTGDLGYL-VDG 460
Cdd:PRK06188 337 R-------LTSCGRPTPGLRVALLDEDGREVAQGEVGEICVRGPLVMDGYWNR--PEETAEafRDGWLHTGDVAREdEDG 407
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 461 QIVICGRRKDVIIMGGRNLYPTDIER--------AATSVEGV---RAGNAV-AVrldagsrrerfaVVLESKLAGDAEAE 528
Cdd:PRK06188 408 FYYIVDRKKDMIVTGGFNVFPREVEDvlaehpavAQVAVIGVpdeKWGEAVtAV------------VVLRPGAAVDAAEL 475
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*..
gi 300790052 529 KNLMKQvsarvRDAVDMRPYAVVVlpAGSLPKTPSGKVKRAATAQQF 575
Cdd:PRK06188 476 QAHVKE-----RKGSVHAPKQVDF--VDSLPLTALGKPDKKALRARY 515
PRK07788 PRK07788
acyl-CoA synthetase; Validated
32-568 1.03e-18

acyl-CoA synthetase; Validated


Pssm-ID: 236097 [Multi-domain]  Cd Length: 549  Bit Score: 89.60  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  32 RTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAE-DTVRVLGMig 110
Cdd:PRK07788  75 LTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLNTGFSGPQLAEVAArEGVKALVY-- 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 111 sDQDALGGPGGLAPR-PGSGAGPRNVTVllGEPFDQLAPVLEQkgigfqlITELAAAEPLPdvVVTDEGdtALLQLTSGS 189
Cdd:PRK07788 153 -DDEFTDLLSALPPDlGRLRAWGGNPDD--DEPSGSTDETLDD-------LIAGSSTAPLP--KPPKPG--GIVILTSGT 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 190 TADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGmVGFLTVPMTFGVELV---KITPVEFLsgpliwpE 266
Cdd:PRK07788 219 TGTPKGAPRPEPSPLAPLAGLLSRVPFRAG-ETTLLPAPMFHATG-WAHLTLAMALGSTVVlrrRFDPEATL-------E 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 267 LITKYHGTT-TAAPNFAyaivgRRMARVDED--DAYDLSKLRIALNGAEPIDETAVQTFVDAgarFkmpAECVFPAYGMA 343
Cdd:PRK07788 290 DIAKHKATAlVVVPVML-----SRILDLGPEvlAKYDTSSLKIIFVSGSALSPELATRALEA---F---GPVLYNLYGST 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 344 EatlaVSFAplftgltldvveadaleaenrAVPVPEgdprrgtDGVRSFALLGRPLDGLEAEIVDDAGKRVDEREVGEIR 423
Cdd:PRK07788 359 E----VAFA---------------------TIATPE-------DLAEAPGTVGRPPKGVTVKILDENGNEVPRGVVGRIF 406
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 424 LRGEAVTPGYLtmdGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAV 502
Cdd:PRK07788 407 VGNGFPFEGYT---DGRDKQIIDGLLSSGDVGYFdEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGV 483
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052 503 RLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARV---RDavdmrpyaVVVLPAgsLPKTPSGKVKR 568
Cdd:PRK07788 484 DDEEFGQRLRAFVVKAPGAALDEDAIKDYVRDNLARYkvpRD--------VVFLDE--LPRNPTGKVLK 542
A_NRPS_VisG_like cd17651
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...
28-570 1.06e-18

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341306 [Multi-domain]  Cd Length: 491  Bit Score: 89.33  E-value: 1.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  28 EPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDT--VRV 105
Cdd:cd17651   17 EGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYPAERLAFMLADAgpVLV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 106 LgmigsdqdalggpggLAPRPGSGAGPRNVTVLLGEPFdqlapvleqkgigfqlitELAAAEPLPDVVVTDEGDTALLQL 185
Cdd:cd17651   97 L---------------THPALAGELAVELVAVTLLDQP------------------GAAAGADAEPDPALDADDLAYVIY 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 186 TSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTvPMTFGVELVKITPVEFLSGPLIWP 265
Cdd:cd17651  144 TSGSTGRPKGVVMPHRSLANLVAWQARASSLGPG-ARTLQFAGLGFDVSVQEIFS-TLCAGATLVLPPEEVRTDPPALAA 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 266 ELITkyHGTTTAapnFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDET-AVQTFVDAgarfkMPAECVFPAYGMAE 344
Cdd:cd17651  222 WLDE--QRISRV---FLPTVALRALAEHGRPLGVRLAALRYLLTGGEQLVLTeDLREFCAG-----LPGLRLHNHYGPTE 291
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 345 ATLAvsfaplfTGLTLDVVEADALEAenravpvpegdprrgtdgvrsfALLGRPLDGLEAEIVDDAGKRVDEREVGEIRL 424
Cdd:cd17651  292 THVV-------TALSLPGDPAAWPAP----------------------PPIGRPIDNTRVYVLDAALRPVPPGVPGELYI 342
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 425 RGEAVTPGYLTMDGpLATQD--EDGWLN------TGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVR 495
Cdd:cd17651  343 GGAGLARGYLNRPE-LTAERfvPDPFVPgarmyrTGDLArWLPDGELEFLGRADDQVKIRGFRIELGEIEAALARHPGVR 421
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300790052 496 AGNAVAVRLDAGSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAvdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:cd17651  422 EAVVLAREDRPGEKRLVAYVVGDPEAPVDAAE---LRAALATHLPEY--MVPSAFVLLDA--LPLTPNGKLDRRA 489
LC_FACS_bac1 cd17641
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ...
33-485 7.17e-18

bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341296 [Multi-domain]  Cd Length: 569  Bit Score: 87.09  E-value: 7.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAA-APVLIAPTVQAVWLAGGSVTMLHQPTPrtdlaewaEDTVRVL----- 106
Cdd:cd17641   13 TWADYADRVRAFALGLLALGVGRGDVVAILGDnRPEWVWAELAAQAIGALSLGIYQDSMA--------EEVAYLLnytga 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 107 -GMIGSDQDALGGPGGLAPRPgsgagPRNVTVLLGEP-----FDQlaPVLEQKGIGFQLITELAAAEP---LPDVVVTDE 177
Cdd:cd17641   85 rVVIAEDEEQVDKLLEIADRI-----PSVRYVIYCDPrgmrkYDD--PRLISFEDVVALGRALDRRDPglyEREVAAGKG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 178 GDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVeRAEFDFDVDVMVSWLPTFHDM--------GMVGFLTV-----PMT 244
Cdd:cd17641  158 EDVAVLCTTSGTTGKPKLAMLSHGNFLGHCAAYL-AADPLGPGDEYVSVLPLPWIGeqmysvgqALVCGFIVnfpeePET 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 245 FGVELVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMarvdeddaydlsklRIALNGAepidetavqtfvD 324
Cdd:cd17641  237 MMEDLREIGPTFVLLPPRVWEGIAADVRARMMDATPFKRFMFELGM--------------KLGLRAL------------D 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 325 AGARFKMPAECVFPAYGMAEATLavsFAPL-----FTGLTLDVVEADALEAEN----RAVPVP----------------- 378
Cdd:cd17641  291 RGKRGRPVSLWLRLASWLADALL---FRPLrdrlgFSRLRSAATGGAALGPDTfrffHAIGVPlkqlygqtelagaytvh 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 379 -EGDPRRGTDGVrsfallgrPLDGLEAEIVddagkrvderEVGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDL 454
Cdd:cd17641  368 rDGDVDPDTVGV--------PFPGTEVRID----------EVGEILVRSPGVFVGYY--KNPEATAedfDEDGWLHTGDA 427
                        490       500       510
                 ....*....|....*....|....*....|...
gi 300790052 455 GYL-VDGQIVICGRRKDVIIMG-GRNLYPTDIE 485
Cdd:cd17641  428 GYFkENGHLVVIDRAKDVGTTSdGTRFSPQFIE 460
EntE COG1021
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...
31-577 7.95e-18

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440644 [Multi-domain]  Cd Length: 533  Bit Score: 86.74  E-value: 7.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  31 RRTWAEVHEEARRIAGGLVAGGFERGTAVGV-----------------LAAAPVLIAPTvqavwlaggsvtmlHQptpRT 93
Cdd:COG1021   50 RLSYAELDRRADRLAAGLLALGLRPGDRVVVqlpnvaefvivffalfrAGAIPVFALPA--------------HR---RA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  94 DLAEWAEDTVRVlGMIGSDQDALGGPGGLAPR-PGSGAGPRNVtVLLGEPFDQLApvleqkgigfqlITELAAAEPLPDV 172
Cdd:COG1021  113 EISHFAEQSEAV-AYIIPDRHRGFDYRALARElQAEVPSLRHV-LVVGDAGEFTS------------LDALLAAPADLSE 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 173 VVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMV--GFLTVPMTFGveLV 250
Cdd:COG1021  179 PRPDPDDVAFFQLSGGTTGLPKLIPRTHDDYLYSVRASAEICGLDAD-TVYLAALPAAHNFPLSspGVLGVLYAGG--TV 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 251 KITPVeflSGPLIWPELITKYHGTTTAA-PnfayAIVGRRMARVDEDDaYDLSKLRIALNGAEPIDETAVQTFVDA-GAR 328
Cdd:COG1021  256 VLAPD---PSPDTAFPLIERERVTVTALvP----PLALLWLDAAERSR-YDLSSLRVLQVGGAKLSPELARRVRPAlGCT 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 329 FKMpaecVFpayGMAEATLavsfapLFTGLtldvveadaleaenravpvpeGDPRRgtdgvRSFALLGRPL-DGLEAEIV 407
Cdd:COG1021  328 LQQ----VF---GMAEGLV------NYTRL---------------------DDPEE-----VILTTQGRPIsPDDEVRIV 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYLV-DGQIVICGRRKDVIIMGGRNLYPTD 483
Cdd:COG1021  369 DEDGNPVPPGEVGELLTRGPYTIRGYY--RAPEHNArafTPDGFYRTGDLVRRTpDGYLVVEGRAKDQINRGGEKIAAEE 446
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 484 IERAATSVEGVRAGNAVAV---RLdaGSRRERFAVVLESKLAgdaeaeknlMKQVSARVRD---AVDMRPYAVVVLPAgs 557
Cdd:COG1021  447 VENLLLAHPAVHDAAVVAMpdeYL--GERSCAFVVPRGEPLT---------LAELRRFLRErglAAFKLPDRLEFVDA-- 513
                        570       580
                 ....*....|....*....|
gi 300790052 558 LPKTPSGKVKRAATAQQFAD 577
Cdd:COG1021  514 LPLTAVGKIDKKALRAALAA 533
PRK12406 PRK12406
long-chain-fatty-acid--CoA ligase; Provisional
31-495 1.21e-17

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 183506 [Multi-domain]  Cd Length: 509  Bit Score: 85.91  E-value: 1.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  31 RRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDT-VRVLgmI 109
Cdd:PRK12406  11 RRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSgARVL--I 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 GSDqDALggpgglapRPGSGAGPRNVTVLLGEPFDQ------LAPVLEQKGIGFQLITELAAAEPLPDVVVTdEGDTALL 183
Cdd:PRK12406  89 AHA-DLL--------HGLASALPAGVTVLSVPTPPEiaaayrISPALLTPPAGAIDWEGWLAQQEPYDGPPV-PQPQSMI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 184 qLTSGSTADPKAVRITygnlysnvKAMVERAEFDFDVDVMVSWLPTfhdmGMVGFLTVPM-------------TFGVELV 250
Cdd:PRK12406 159 -YTSGTTGHPKGVRRA--------APTPEQAAAAEQMRALIYGLKP----GIRALLTGPLyhsapnayglragRLGGVLV 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 251 ---KITPVEFLSgpLIWPELITKYHGTTTaapnfayaIVGRRMARVDEDDA-YDLSKLRIALNGAEPIDETAVQTFVDag 326
Cdd:PRK12406 226 lqpRFDPEELLQ--LIERHRITHMHMVPT--------MFIRLLKLPEEVRAkYDVSSLRHVIHAAAPCPADVKRAMIE-- 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 327 arFKMPAECVFpaYGMAEaTLAVSFAplftgltldvVEADALEaenravpvpegdpRRGTdgvrsfalLGRPLDGLEAEI 406
Cdd:PRK12406 294 --WWGPVIYEY--YGSTE-SGAVTFA----------TSEDALS-------------HPGT--------VGKAAPGAELRF 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 407 VDDAGKRVDEREVGEIRLRGEAVTP-GYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDI 484
Cdd:PRK12406 338 VDEDGRPLPQGEIGEIYSRIAGNPDfTYHNKPEKRAEIDRGGFITSGDVGYLdADGYLFLCDRKRDMVISGGVNIYPAEI 417
                        490
                 ....*....|.
gi 300790052 485 ERAATSVEGVR 495
Cdd:PRK12406 418 EAVLHAVPGVH 428
PRK06018 PRK06018
putative acyl-CoA synthetase; Provisional
176-585 2.42e-17

putative acyl-CoA synthetase; Provisional


Pssm-ID: 235673 [Multi-domain]  Cd Length: 542  Bit Score: 85.19  E-value: 2.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 176 DEGDTALLQLTSGSTADPKAVRITY-GNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMVGFLTVPMTfGVELVkiTP 254
Cdd:PRK06018 175 DENTAAGMCYTSGTTGDPKGVLYSHrSNVLHALMANNGDALGTSAADTMLPVVPLFHANSWGIAFSAPSM-GTKLV--MP 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 255 VEFLSGPLIWpELITKYHGTTTAAPNFAYAIVGRRMarvdEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARfkmpae 334
Cdd:PRK06018 252 GAKLDGASVY-ELLDTEKVTFTAGVPTVWLMLLQYM----EKEGLKLPHLKMVVCGGSAMPRSMIKAFEDMGVE------ 320
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 335 cVFPAYGMAE----ATLAvSFAPLFTGLTLDVvEADALEAEnravpvpegdprrgtdgvrsfallGRPLDGLEAEIVDDA 410
Cdd:PRK06018 321 -VRHAWGMTEmsplGTLA-ALKPPFSKLPGDA-RLDVLQKQ------------------------GYPPFGVEMKITDDA 373
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 411 GKRV--DEREVGEIRLRGEAVTPGYLTMDGPLAtqDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERA 487
Cdd:PRK06018 374 GKELpwDGKTFGRLKVRGPAVAAAYYRVDGEIL--DDDGFFDTGDVATIdAYGYMRITDRSKDVIKSGGEWISSIDLENL 451
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 488 ATSVEGVRAGNAVAVRLDAGSRRERFAVVLEsklAGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLpaGSLPKTPSGKVK 567
Cdd:PRK06018 452 AVGHPKVAEAAVIGVYHPKWDERPLLIVQLK---PGETATREEILKYMDGKI--AKWWMPDDVAFV--DAIPHTATGKIL 524
                        410
                 ....*....|....*...
gi 300790052 568 RAATAQQFADRIKKNADA 585
Cdd:PRK06018 525 KTALREQFKDYKLPTAAA 542
PLN02860 PLN02860
o-succinylbenzoate-CoA ligase
8-485 2.50e-17

o-succinylbenzoate-CoA ligase


Pssm-ID: 215464 [Multi-domain]  Cd Length: 563  Bit Score: 85.24  E-value: 2.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   8 LVATATKRGQQRGMVTGEPkepvRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLH 87
Cdd:PLN02860  13 LTRLATLRGNAVVTISGNR----RRTGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  88 QptpRTDLAEwAEDTVRVLG--MIGSDQDALGGPgglaPRPGSGAGPR-NVTVLLGEPFDQLAPVLEQKgIGFQLITELA 164
Cdd:PLN02860  89 Y---RWSFEE-AKSAMLLVRpvMLVTDETCSSWY----EELQNDRLPSlMWQVFLESPSSSVFIFLNSF-LTTEMLKQRA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 165 AAEPLPDVVVTDEgDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMT 244
Cdd:PLN02860 160 LGTTELDYAWAPD-DAVLICFTSGTTGRPKGVTISHSALIVQSLAKIAIVGYGED-DVYLHTAPLCHIGGLSSALAMLMV 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 245 FGVELvkITPvEFLSGPLIwpELITKYHGTT-TAAPNFAYAIVgrRMARVDEDDAYDLSKLRIaLNGAEPID----ETAV 319
Cdd:PLN02860 238 GACHV--LLP-KFDAKAAL--QAIKQHNVTSmITVPAMMADLI--SLTRKSMTWKVFPSVRKI-LNGGGSLSsrllPDAK 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 320 QTFvdagarfkmPAECVFPAYGMAEATLAVSFAPLF--TGLTLDVVEADALEAENRAVPVPEGdprrgtdgvrsfALLGR 397
Cdd:PLN02860 310 KLF---------PNAKLFSAYGMTEACSSLTFMTLHdpTLESPKQTLQTVNQTKSSSVHQPQG------------VCVGK 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 398 PLDGLEAEIVDDAGKRVderevGEIRLRGEAVTPGYltMDGPLATQDE---DGWLNTGDLGYLVD-GQIVICGRRKDVII 473
Cdd:PLN02860 369 PAPHVELKIGLDESSRV-----GRILTRGPHVMLGY--WGQNSETASVlsnDGWLDTGDIGWIDKaGNLWLIGRSNDRIK 441
                        490
                 ....*....|..
gi 300790052 474 MGGRNLYPTDIE 485
Cdd:PLN02860 442 TGGENVYPEEVE 453
PRK07638 PRK07638
acyl-CoA synthetase; Validated
396-580 4.14e-17

acyl-CoA synthetase; Validated


Pssm-ID: 236071 [Multi-domain]  Cd Length: 487  Bit Score: 84.45  E-value: 4.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIM 474
Cdd:PRK07638 310 GRPFHNVQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYIIGGVLARELNADGWMTVRDVGYEdEEGFIYIVGREKNMILF 389
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 475 GGRNLYPTDIERAATSVEGVRagNAVAVrldaGSRRERFAVVLESKLAGDAEAeknlmKQVSARVRD--AVDMRPYAVVV 552
Cdd:PRK07638 390 GGINIFPEEIESVLHEHPAVD--EIVVI----GVPDSYWGEKPVAIIKGSATK-----QQLKSFCLQrlSSFKIPKEWHF 458
                        170       180
                 ....*....|....*....|....*...
gi 300790052 553 lpAGSLPKTPSGKVKRAATAQQFADRIK 580
Cdd:PRK07638 459 --VDEIPYTNSGKIARMEAKSWIENQEK 484
A_NRPS_Srf_like cd12117
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...
33-570 7.39e-17

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.


Pssm-ID: 341282 [Multi-domain]  Cd Length: 483  Bit Score: 83.40  E-value: 7.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAA-APVLIAPTVqAVWLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmigs 111
Cdd:cd12117   24 TYAELNERANRLARRLRAAGVGPGDVVGVLAErSPELVVALL-AVLKAGAAYVPLDPELPAERLAFMLAD---------- 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 112 dqdalggpgglaprpgsgAGPRnvTVLLGEPFDQLAPVLEQKGIGFQlitELAAAEPLPDVVVTDEGDTALLQLTSGSTA 191
Cdd:cd12117   93 ------------------AGAK--VLLTDRSLAGRAGGLEVAVVIDE---ALDAGPAGNPAVPVSPDDLAYVMYTSGSTG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 192 DPKAVRITYGN---LYSNVKAMVERAEfdfDVDVMVSWLP----TFHdmgmvgfLTVPMTFGVELVkITPVEFLSGPLIW 264
Cdd:cd12117  150 RPKGVAVTHRGvvrLVKNTNYVTLGPD---DRVLQTSPLAfdasTFE-------IWGALLNGARLV-LAPKGTLLDPDAL 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 265 PELITKyHGTTTAapnFAYAIVGRRMARVDEDDaydLSKLRIALNGAEPIDETAVQTFVDAGARFKmpaecVFPAYGMAE 344
Cdd:cd12117  219 GALIAE-EGVTVL---WLTAALFNQLADEDPEC---FAGLRELLTGGEVVSPPHVRRVLAACPGLR-----LVNGYGPTE 286
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 345 ATLavsfaplFTglTLDVVEADALEAEnravPVPegdprrgtdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRL 424
Cdd:cd12117  287 NTT-------FT--TSHVVTELDEVAG----SIP----------------IGRPIANTRVYVLDEDGRPVPPGVPGELYV 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 425 RGEAVTPGYLtmDGPLATQD---EDGWLN------TGDL-GYLVDGQIVICGRRKD-VIIMGGRnLYPTDIERAATSVEG 493
Cdd:cd12117  338 GGDGLALGYL--NRPALTAErfvADPFGPgerlyrTGDLaRWLPDGRLEFLGRIDDqVKIRGFR-IELGEIEAALRAHPG 414
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300790052 494 VRAgNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARvrdavdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:cd12117  415 VRE-AVVVVREDAGGDKRLVAYVVAEGALDAAELRAFLRERLPAY------MVPAAFVVLDE--LPLTANGKVDRRA 482
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
170-485 9.92e-17

long-chain-fatty-acid--CoA ligase FadD;


Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 83.56  E-value: 9.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDegdTALLQLTSGSTADPKAVRITYGNLYSNVK--------AMVERAEFdfdvdvMVSWLPTFHdmgmVGFLTV 241
Cdd:PRK08974 201 PELVPED---LAFLQYTGGTTGVAKGAMLTHRNMLANLEqakaaygpLLHPGKEL------VVTALPLYH----IFALTV 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 242 PMTFGVEL----VKIT-PVEFlsgPLIWPELiTKYHGTTTAAPNFAY-AIVGRrmarvDEDDAYDLSKLRIALNGAEPId 315
Cdd:PRK08974 268 NCLLFIELggqnLLITnPRDI---PGFVKEL-KKYPFTAITGVNTLFnALLNN-----EEFQELDFSSLKLSVGGGMAV- 337
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 316 ETAVQTfvdagaRFKMPAEC-VFPAYGMAEAtlavsfAPLFTGLTLDVVEADAleaeNRAVPVPEGDPRrgtdgvrsfal 394
Cdd:PRK08974 338 QQAVAE------RWVKLTGQyLLEGYGLTEC------SPLVSVNPYDLDYYSG----SIGLPVPSTEIK----------- 390
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 lgrpldgleaeIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQD--EDGWLNTGDLGYLVD-GQIVICGRRKDV 471
Cdd:PRK08974 391 -----------LVDDDGNEVPPGEPGELWVKGPQVMLGYWQR--PEATDEviKDGWLATGDIAVMDEeGFLRIVDRKKDM 457
                        330
                 ....*....|....
gi 300790052 472 IIMGGRNLYPTDIE 485
Cdd:PRK08974 458 ILVSGFNVYPNEIE 471
A_NRPS_AB3403-like cd17646
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...
8-570 1.70e-16

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341301 [Multi-domain]  Cd Length: 488  Bit Score: 82.32  E-value: 1.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   8 LVATATKRGQQRGMVTGEPkepVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLH 87
Cdd:cd17646    3 LVAEQAARTPDAPAVVDEG---RTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  88 QPTPRTDLAEWAEDTVRVLGMIGSDQDALGGPGGLAPRPGSgagprnvtvllgepfdqlapvleqkgigfqliTELAAAE 167
Cdd:cd17646   80 PGYPADRLAYMLADAGPAVVLTTADLAARLPAGGDVALLGD--------------------------------EALAAPP 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 168 PLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFhDMGMVGFLtVPMTFGV 247
Cdd:cd17646  128 ATPPLVPPRPDNLAYVIYTSGSTGRPKGVMVTHAGIVNRLLWMQDEYPLGPGDRVLQKTPLSF-DVSVWELF-WPLVAGA 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 248 ELVkITPVEFLSGPLIWPELITKyHGTTTAapNFAYAIVGrrmARVDEDDAYDLSKLRIALNGAEPIDetavqtfVDAGA 327
Cdd:cd17646  206 RLV-VARPGGHRDPAYLAALIRE-HGVTTC--HFVPSMLR---VFLAEPAAGSCASLRRVFCSGEALP-------PELAA 271
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 328 RF-KMPAECVFPAYGMAEATLAVSfaplftgltldvveADALEAENRAVPVPegdprrgtdgvrsfalLGRPLDGLEAEI 406
Cdd:cd17646  272 RFlALPGAELHNLYGPTEAAIDVT--------------HWPVRGPAETPSVP----------------IGRPVPNTRLYV 321
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 407 VDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLN-------TGDLG-YLVDGQIVICGRRKDVIIMGGRN 478
Cdd:cd17646  322 LDDALRPVPVGVPGELYLGGVQLARGYLGRPALTAERFVPDPFGpgsrmyrTGDLArWRPDGALEFLGRSDDQVKIRGFR 401
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 479 LYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEknLMKQVSARVRDAvdMRPYAVVVLPAgsL 558
Cdd:cd17646  402 VEPGEIEAALAAHPAVTHAVVVARAAPAGAARLVGYVVPAAGAAGPDTAA--LRAHLAERLPEY--MVPAAFVVLDA--L 475
                        570
                 ....*....|..
gi 300790052 559 PKTPSGKVKRAA 570
Cdd:cd17646  476 PLTANGKLDRAA 487
PRK04813 PRK04813
D-alanine--poly(phosphoribitol) ligase subunit DltA;
186-573 1.96e-16

D-alanine--poly(phosphoribitol) ligase subunit DltA;


Pssm-ID: 235313 [Multi-domain]  Cd Length: 503  Bit Score: 82.25  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 186 TSGSTADPKAVRITYGNLYSNVKAMVE------------RAEFDFDVDVMvSWLPTFHDMGMVGFLTVPMT--FGV--EL 249
Cdd:PRK04813 151 TSGTTGKPKGVQISHDNLVSFTNWMLEdfalpegpqflnQAPYSFDLSVM-DLYPTLASGGTLVALPKDMTanFKQlfET 229
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 250 VKITPVEflsgplIWpelitkyhgttTAAPNFAyaivgrRMARVDED-DAYDLSKLRIAL-NGAEPIDETAvQTFVDaga 327
Cdd:PRK04813 230 LPQLPIN------VW-----------VSTPSFA------DMCLLDPSfNEEHLPNLTHFLfCGEELPHKTA-KKLLE--- 282
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 328 RFkmPAECVFPAYGMAEATLAVsfaplfTGLTldvVEADALEAENRaVPVpegdprrgtdgvrsfallGRPLDGLEAEIV 407
Cdd:PRK04813 283 RF--PSATIYNTYGPTEATVAV------TSIE---ITDEMLDQYKR-LPI------------------GYAKPDSPLLII 332
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQ----DEDGW--LNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYP 481
Cdd:PRK04813 333 DEEGTKLPDGEQGEIVISGPSVSKGYL--NNPEKTAeaffTFDGQpaYHTGDAGYLEDGLLFYQGRIDFQIKLNGYRIEL 410
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 482 TDIERAATSVEGVRagNAVAVRLDAGSRRERFAVVLESKlAGDAEAEKNLMKQVSARVRDavDMRPYavvVLPA-----G 556
Cdd:PRK04813 411 EEIEQNLRQSSYVE--SAVVVPYNKDHKVQYLIAYVVPK-EEDFEREFELTKAIKKELKE--RLMEY---MIPRkfiyrD 482
                        410
                 ....*....|....*..
gi 300790052 557 SLPKTPSGKVKRAATAQ 573
Cdd:PRK04813 483 SLPLTPNGKIDRKALIE 499
A_NRPS_PpsD_like cd17650
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...
171-570 2.28e-16

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341305 [Multi-domain]  Cd Length: 447  Bit Score: 81.74  E-value: 2.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 171 DVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFD-----------FDVDVmvswlptfhdmgMVGFL 239
Cdd:cd17650   86 KLLLTQPEDLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELDsfpvrllqmasFSFDV------------FAGDF 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 240 TVPMTFGVELVkITPVEFLSGPLIWPELITKYHGTT-TAAPNFAYAIvgrrMARVDEDDaYDLSKLRIALNGAepiDETA 318
Cdd:cd17650  154 ARSLLNGGTLV-ICPDEVKLDPAALYDLILKSRITLmESTPALIRPV----MAYVYRNG-LDLSAMRLLIVGS---DGCK 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 319 VQTFVDAGARFKMPAECVfPAYGMAEATLAVSFAPlftgltldvvEADALEAENRAVPVpegdprrgtdgvrsfallGRP 398
Cdd:cd17650  225 AQDFKTLAARFGQGMRII-NSYGVTEATIDSTYYE----------EGRDPLGDSANVPI------------------GRP 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 399 LDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLT---------MDGPLATQDEdgWLNTGDLG-YLVDGQIVICGRR 468
Cdd:cd17650  276 LPNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNrpeltaerfVENPFAPGER--MYRTGDLArWRADGNVELLGRV 353
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 469 KDVIIMGGRNLYPTDIERAATSVEGVRAGnAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARvrdavdMRPY 548
Cdd:cd17650  354 DHQVKIRGFRIELGEIESQLARHPAIDEA-VVAVREDKGGEARLCAYVVAAATLNTAELRAFLAKELPSY------MIPS 426
                        410       420
                 ....*....|....*....|..
gi 300790052 549 AVVVLPAgsLPKTPSGKVKRAA 570
Cdd:cd17650  427 YYVQLDA--LPLTPNGKVDRRA 446
AFD_YhfT-like cd17633
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...
396-568 2.68e-16

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain


Pssm-ID: 341288 [Multi-domain]  Cd Length: 320  Bit Score: 80.14  E-value: 2.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGkrvdeREVGEIRLRGEAVTPGYLTMDGplatQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIM 474
Cdd:cd17633  166 GRPFPNVEIEIRNADG-----GEIGKIFVKSEMVFSGYVRGGF----SNPDGWMSVGDIGYVdEEGYLYLVGRESDMIII 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 475 GGRNLYPTDIERAATSVEGVRagNAVAVRLdAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRdavdmRPYAVVVLp 554
Cdd:cd17633  237 GGINIFPTEIESVLKAIPGIE--EAIVVGI-PDARFGEIAVALYSGDKLTYKQLKRFLKQKLSRYE-----IPKKIIFV- 307
                        170
                 ....*....|....
gi 300790052 555 aGSLPKTPSGKVKR 568
Cdd:cd17633  308 -DSLPYTSSGKIAR 320
PRK06155 PRK06155
crotonobetaine/carnitine-CoA ligase; Provisional
31-569 2.79e-16

crotonobetaine/carnitine-CoA ligase; Provisional


Pssm-ID: 235719 [Multi-domain]  Cd Length: 542  Bit Score: 82.11  E-value: 2.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  31 RRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAA-APVLIAPTVQAVWLAGGSV---TMLHQPTPRTDLAEwaedtvrvl 106
Cdd:PRK06155  46 RWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGnRIEFLDVFLGCAWLGAIAVpinTALRGPQLEHILRN--------- 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 107 gmigSDQDALGGPGGLAPRPGS---GAGPRNVTVLLGEPFDQLAPVleqkgiGFQLITELAAAEPLPDVVVTDeGDTALL 183
Cdd:PRK06155 117 ----SGARLLVVEAALLAALEAadpGDLPLPAVWLLDAPASVSVPA------GWSTAPLPPLDAPAPAAAVQP-GDTAAI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 184 QLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVpMTFGVELVkITPVEFLSGplI 263
Cdd:PRK06155 186 LYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGAD-DVLYTTLPLFHTNALNAFFQA-LLAGATYV-LEPRFSASG--F 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 264 WPELitKYHGTTtaapnFAY---AIVGRRMARVDEDDAYDlSKLRIALNGAEPidetaVQTFVDAGARFKMPAecvFPAY 340
Cdd:PRK06155 261 WPAV--RRHGAT-----VTYllgAMVSILLSQPARESDRA-HRVRVALGPGVP-----AALHAAFRERFGVDL---LDGY 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 341 GMAEAtlavsfaplftgltldvveadaleaeNRAVPVPEGDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVG 420
Cdd:PRK06155 325 GSTET--------------------------NFVIAVTHGSQRPGS--------MGRLAPGFEARVVDEHDQELPDGEPG 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 421 EIRLRGE---AVTPGYLTMdgPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGV 494
Cdd:PRK06155 371 ELLLRADepfAFATGYFGM--PEKTVEawRNLWFHTGDRVVRdADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSHPAV 448
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300790052 495 RAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAeknLMKQVSARVrdavdmrPYAVV---VLPAGSLPKTPSGKVKRA 569
Cdd:PRK06155 449 AAAAVFPVPSELGEDEVMAAVVLRDGTALEPVA---LVRHCEPRL-------AYFAVpryVEFVAALPKTENGKVQKF 516
PRK13382 PRK13382
bile acid CoA ligase;
158-569 3.12e-16

bile acid CoA ligase;


Pssm-ID: 172019 [Multi-domain]  Cd Length: 537  Bit Score: 81.73  E-value: 3.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 158 QLITELAAAEPLPdvvVTDEGDTALLqlTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSwLPTFHDMgmvG 237
Cdd:PRK13382 181 VLIAAHAGQRPEP---TGRKGRVILL--TSGTTGTPKGARRSGPGGIGTLKAILDRTPWRAEEPTVIV-APMFHAW---G 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 238 FLTVPMTFGVELVKITPVEFlsGPLIWPELITKYHGTTTAapnfAYAIVGRRMARVDED--DAYDLSKLRIALNGAEPID 315
Cdd:PRK13382 252 FSQLVLAASLACTIVTRRRF--DPEATLDLIDRHRATGLA----VVPVMFDRIMDLPAEvrNRYSGRSLRFAAASGSRMR 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 316 ETAVQTFVDagaRFkmpAECVFPAYGMAEATLAVSFAPlftgltldvveADALEAENRAvpvpegdprrgtdgvrsfall 395
Cdd:PRK13382 326 PDVVIAFMD---QF---GDVIYNNYNATEAGMIATATP-----------ADLRAAPDTA--------------------- 367
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLtmdgPLATQD-EDGWLNTGDLGYLVD-GQIVICGRRKDVII 473
Cdd:PRK13382 368 GRPAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGYT----SGSTKDfHDGFMASGDVGYLDEnGRLFVVGRDDEMIV 443
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 474 MGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKnlmkqvsARVRD--AVDMRPYAVV 551
Cdd:PRK13382 444 SGGENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQRLAAFVVLKPGASATPETLK-------QHVRDnlANYKVPRDIV 516
                        410
                 ....*....|....*...
gi 300790052 552 VLPagSLPKTPSGKVKRA 569
Cdd:PRK13382 517 VLD--ELPRGATGKILRR 532
PRK12316 PRK12316
peptide synthase; Provisional
31-570 3.88e-16

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 82.70  E-value: 3.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   31 RRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDT-VRVLgmi 109
Cdd:PRK12316 3082 RLSYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEMVVGLLAILKAGGAYVPLDPEYPEERLAYMLEDSgAQLL--- 3158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  110 gsdqdalggpggLAPRPGSGAGPRNVTVLLGEPFDQlapvleqkgigfqlitelAAAEPLPDVVVTDEgDTALLQLTSGS 189
Cdd:PRK12316 3159 ------------LSQSHLRLPLAQGVQVLDLDRGDE------------------NYAEANPAIRTMPE-NLAYVIYTSGS 3207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  190 TADPKAVRITYGNLYSNVKAMVEraEFDFDVDVMVSWLPTFHDMGMVGFLTVPMTFGVELVkitpvefLSGPLIWPELIT 269
Cdd:PRK12316 3208 TGKPKGVGIRHSALSNHLCWMQQ--AYGLGVGDRVLQFTTFSFDVFVEELFWPLMSGARVV-------LAGPEDWRDPAL 3278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  270 KYHGTTTAAPNFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGArfkmpaecVFPAYGMAEATLav 349
Cdd:PRK12316 3279 LVELINSEGVDVLHAYPSMLQAFLEEEDAHRCTSLKRIVCGGEALPADLQQQVFAGLP--------LYNLYGPTEATI-- 3348
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  350 sfaplfTGLTLDVVEADaleaenravpvpegdprrgtdgvRSFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAV 429
Cdd:PRK12316 3349 ------TVTHWQCVEEG-----------------------KDAVPIGRPIANRACYILDGSLEPVPVGALGELYLGGEGL 3399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  430 TPGYLTMDG-------PLATQDEDGWLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAgnavA 501
Cdd:PRK12316 3400 ARGYHNRPGltaerfvPDPFVPGERLYRTGDLArYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWVRE----A 3475
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052  502 VRLDAGSRRERFAVVLESKlagDAEAEKNLMKQVSARVRDAvdMRPYAVVVLPagSLPKTPSGKVKRAA 570
Cdd:PRK12316 3476 VVLAVDGRQLVAYVVPEDE---AGDLREALKAHLKASLPEY--MVPAHLLFLE--RMPLTPNGKLDRKA 3537
PLN02574 PLN02574
4-coumarate--CoA ligase-like
33-568 4.25e-16

4-coumarate--CoA ligase-like


Pssm-ID: 215312 [Multi-domain]  Cd Length: 560  Bit Score: 81.43  E-value: 4.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLV-AGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDTVRVLGMIGS 111
Cdd:PLN02574  68 SYSELQPLVKSMAAGLYhVMGVRQGDVVLLLLPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIKKRVVDCSVGLAFTSP 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 112 DQ----DALGGPGGLAPRPGSgagprnvtvllgepFDQLAPvleQKGIGFQLITElaAAEPLPDVVVTDEgDTALLQLTS 187
Cdd:PLN02574 148 ENveklSPLGVPVIGVPENYD--------------FDSKRI---EFPKFYELIKE--DFDFVPKPVIKQD-DVAAIMYSS 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 188 GSTADPKAVRITYGNLYSNVKAMV--ERAEFDFDV--DVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITpvEFLSGPLI 263
Cdd:PLN02574 208 GTTGASKGVVLTHRNLIAMVELFVrfEASQYEYPGsdNVYLAALPMFHIYGLSLFVVGLLSLGSTIVVMR--RFDASDMV 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 264 wpELITKYHGTT-TAAPNFAYAIVgrRMARvdEDDAYDLSKLRIALNGAEPIDETAVQTFVDAgarfkMPAECVFPAYGM 342
Cdd:PLN02574 286 --KVIDRFKVTHfPVVPPILMALT--KKAK--GVCGEVLKSLKQVSCGAAPLSGKFIQDFVQT-----LPHVDFIQGYGM 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 343 AEATlAVSfaplftgltldvveadaleaenravpvpegdpRRG--TDGVRSFALLGRPLDGLEAEIVD-DAGKRVDEREV 419
Cdd:PLN02574 355 TEST-AVG--------------------------------TRGfnTEKLSKYSSVGLLAPNMQAKVVDwSTGCLLPPGNC 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 420 GEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATS-VEGV 494
Cdd:PLN02574 402 GELWIQGPGVMKGYL--NNPKATQstiDKDGWLRTGDIAYFdEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLIShPEII 479
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300790052 495 RAGNAVAVRLDAGSRRERFAVvlesKLAGDAEAEKNLMKQVSARVrdavdmRPYAVV--VLPAGSLPKTPSGKVKR 568
Cdd:PLN02574 480 DAAVTAVPDKECGEIPVAFVV----RRQGSTLSQEAVINYVAKQV------APYKKVrkVVFVQSIPKSPAGKILR 545
MACS_like_3 cd05971
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
29-568 8.70e-16

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341275 [Multi-domain]  Cd Length: 439  Bit Score: 79.78  E-value: 8.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  29 PVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAapvliaptvqavwlaggsvtmlhqPTPRTDLAEWAedtVRVLGM 108
Cdd:cd05971    4 PEKVTFKELKTASNRFANVLKEIGLEKGDRVGVFLS------------------------QGPECAIAHIA---ILRSGA 56
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 109 IGSDQDALGGPGGLAPR-PGSGAgprnvtvllgepfdqlapvleqkgigfqlitelaaaeplpDVVVTDEG-DTALLQLT 186
Cdd:cd05971   57 IAVPLFALFGPEALEYRlSNSGA----------------------------------------SALVTDGSdDPALIIYT 96
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 187 SGSTADPKAV----RITYGNLysnvkAMVERAEFDFDVDVMVSWLPTfhDMGMVGFL---TVP-MTFGVELVKITPVEFL 258
Cdd:cd05971   97 SGTTGPPKGAlhahRVLLGHL-----PGVQFPFNLFPRDGDLYWTPA--DWAWIGGLldvLLPsLYFGVPVLAHRMTKFD 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 259 SGPLIwpELITKyHGTTTAapnFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAgarFKMPaecVFP 338
Cdd:cd05971  170 PKAAL--DLMSR-YGVTTA---FLPPTALKMMRQQGEQLKHAQVKLRAIATGGESLGEELLGWAREQ---FGVE---VNE 237
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 339 AYGMAEATLAVSFAPLFtgltldvveadaleaenravpvpeGDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDERE 418
Cdd:cd05971  238 FYGQTECNLVIGNCSAL------------------------FPIKPGS--------MGKPIPGHRVAIVDDNGTPLPPGE 285
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 419 VGEIRLRgeavTPGYLTM----DGPLATQDE--DGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSV 491
Cdd:cd05971  286 VGEIAVE----LPDPVAFlgywNNPSATEKKmaGDWLLTGDLGRKdSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKH 361
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 492 EGVRagNAVAVRLDAGSRRE---RFAVVLESKLAGDAeaeknLMKQVSARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKR 568
Cdd:cd05971  362 PAVL--MAAVVGIPDPIRGEivkAFVVLNPGETPSDA-----LAREIQELVKTRLAAHEYPREIEFVNELPRTATGKIRR 434
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
179-566 9.25e-16

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 81.12  E-value: 9.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  179 DTALLQLTSGSTADPKAVRITYGNLYSNVKA--MVERAEFDfdvDVMVSWLPTFHDMGMVGFLTVPMTFGVelvkitPVE 256
Cdd:PRK08633  783 DTATIIFSSGSEGEPKGVMLSHHNILSNIEQisDVFNLRND---DVILSSLPFFHSFGLTVTLWLPLLEGI------KVV 853
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  257 FLSGPL----IwPELITKYHGTTT-AAPNF--AYAivgrRMARVDEDdayDLSKLRIALNGAEPIDETAVQTFVDagaRF 329
Cdd:PRK08633  854 YHPDPTdalgI-AKLVAKHRATILlGTPTFlrLYL----RNKKLHPL---MFASLRLVVAGAEKLKPEVADAFEE---KF 922
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  330 KMPaecVFPAYGMAEATlavsfaPLFTGLTLDVVEADALEaenravpvpEGDPRRGTdgvrsfalLGRPLDGLEAEIVD- 408
Cdd:PRK08633  923 GIR---ILEGYGATETS------PVASVNLPDVLAADFKR---------QTGSKEGS--------VGMPLPGVAVRIVDp 976
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  409 DAGKRVDEREVGEIRLRGEAVTPGYLtmDGP------LATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGG----- 476
Cdd:PRK08633  977 ETFEELPPGEDGLILIGGPQVMKGYL--GDPektaevIKDIDGIGWYVTGDKGHLdEDGFLTITDRYSRFAKIGGemvpl 1054
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  477 --------RNLYPTDIERAATSVEGVRAGNAVavrldagsrrerfaVVLESKLAGDAEAEKNLMKQVSarvrDAVDMRPY 548
Cdd:PRK08633 1055 gaveeelaKALGGEEVVFAVTAVPDEKKGEKL--------------VVLHTCGAEDVEELKRAIKESG----LPNLWKPS 1116
                         410
                  ....*....|....*...
gi 300790052  549 AVVVLPAgsLPKTPSGKV 566
Cdd:PRK08633 1117 RYFKVEA--LPLLGSGKL 1132
EntF COG1020
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...
33-578 9.70e-16

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440643 [Multi-domain]  Cd Length: 1329  Bit Score: 81.06  E-value: 9.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTML--HQPTPRtdLAEWAEDtvrvlgmig 110
Cdd:COG1020   503 TYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLdpAYPAER--LAYMLED--------- 571
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  111 sdqdalggpgglaprpgsgAGPRnvtVLLGEPfdQLAPVLEQKGIGFQLI--TELAAAEPLPDVVVTDEGDTALLQLTSG 188
Cdd:COG1020   572 -------------------AGAR---LVLTQS--ALAARLPELGVPVLALdaLALAAEPATNPPVPVTPDDLAYVIYTSG 627
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  189 STADPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHDMGMVGFLtVPMTFGVELVkITPVEFLSGPLIWPELI 268
Cdd:COG1020   628 STGRPKGVMVEHRALVNLLAWMQRRYGLG-PGDRVLQFASLSFDASVWEIF-GALLSGATLV-LAPPEARRDPAALAELL 704
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  269 TKYHGTT-TAAPNFAYAIVgrrmarvdEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARFKmpaecVFPAYGMAEATL 347
Cdd:COG1020   705 ARHRVTVlNLTPSLLRALL--------DAAPEALPSLRLVLVGGEALPPELVRRWRARLPGAR-----LVNLYGPTETTV 771
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  348 AVSFAPLftgltldvveaDALEAENRAVPVpegdprrgtdgvrsfallGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGE 427
Cdd:COG1020   772 DSTYYEV-----------TPPDADGGSVPI------------------GRPIANTRVYVLDAHLQPVPVGVPGELYIGGA 822
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  428 AVTPGYLTMDGPLATQ------DEDG--WLNTGDLG-YLVDGQIVICGRRKD-VIIMGGRnLYPTDIERAATSVEGVRAG 497
Cdd:COG1020   823 GLARGYLNRPELTAERfvadpfGFPGarLYRTGDLArWLPDGNLEFLGRADDqVKIRGFR-IELGEIEAALLQHPGVREA 901
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  498 nAVAVRLDAGSRRERFAVVLESKLAGDAEAEknlmkqVSARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKRAATAQQFAD 577
Cdd:COG1020   902 -VVVAREDAPGDKRLVAYVVPEAGAAAAAAL------LRLALALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALPAPAAA 974

                  .
gi 300790052  578 R 578
Cdd:COG1020   975 A 975
PRK12316 PRK12316
peptide synthase; Provisional
31-570 9.74e-16

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 81.54  E-value: 9.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   31 RRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDT-VRVLGMI 109
Cdd:PRK12316  536 TLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDPEYPAERLAYMLEDSgVQLLLSQ 615
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  110 GSDQDALGGPGGlaprpgsgagprnVTVLLgepFDQLAPVLEqkgigfqlitelAAAEPLPDVVVTDEgDTALLQLTSGS 189
Cdd:PRK12316  616 SHLGRKLPLAAG-------------VQVLD---LDRPAAWLE------------GYSEENPGTELNPE-NLAYVIYTSGS 666
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  190 TADPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHDMGMVGFLtVPMTFGVELVkITPVEFLSGPLIWPELIT 269
Cdd:PRK12316  667 TGKPKGAGNRHRALSNRLCWMQQAYGLG-VGDTVLQKTPFSFDVSVWEFF-WPLMSGARLV-VAAPGDHRDPAKLVELIN 743
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  270 KyHGTTT--AAPNFAYAIVGrrmarvDEDDAYDLSKLRIALNGaEPIDETAVQTFVDagarfKMPAECVFPAYGMAEATL 347
Cdd:PRK12316  744 R-EGVDTlhFVPSMLQAFLQ------DEDVASCTSLRRIVCSG-EALPADAQEQVFA-----KLPQAGLYNLYGPTEAAI 810
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  348 avsfaplftgltlDVVEADALEAENRAVPVpegdprrgtdgvrsfallGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGE 427
Cdd:PRK12316  811 -------------DVTHWTCVEEGGDSVPI------------------GRPIANLACYILDANLEPVPVGVLGELYLAGR 859
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  428 AVTPGY-----LTMDGPLATQDEDG--WLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAgna 499
Cdd:PRK12316  860 GLARGYhgrpgLTAERFVPSPFVAGerMYRTGDLArYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVRE--- 936
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300790052  500 vAVRLDAGSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAvdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:PRK12316  937 -AAVLAVDGKQLVGYVVLESEGGDWREA---LKAHLAASLPEY--MVPAQWLALER--LPLTPNGKLDRKA 999
PLN03102 PLN03102
acyl-activating enzyme; Provisional
167-566 1.12e-15

acyl-activating enzyme; Provisional


Pssm-ID: 215576 [Multi-domain]  Cd Length: 579  Bit Score: 80.06  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 167 EPLPDVV-----VTDEGDTALLQLTSGSTADPKAVRITYGNLY-SNVKAMVERAEFDFDVDVmvsW-LPTFHDMGMVgfl 239
Cdd:PLN03102 170 EPTPSLVarmfrIQDEHDPISLNYTSGTTADPKGVVISHRGAYlSTLSAIIGWEMGTCPVYL---WtLPMFHCNGWT--- 243
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 240 tvpMTFGVELVKITPV--EFLSGPLIWPELitKYHGTT--TAAPN-FAYAIVGRRMarvdeDDAYDLSKLRIaLNGAEPI 314
Cdd:PLN03102 244 ---FTWGTAARGGTSVcmRHVTAPEIYKNI--EMHNVThmCCVPTvFNILLKGNSL-----DLSPRSGPVHV-LTGGSPP 312
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 315 DETAVQTFVDAGARfkmpaecVFPAYGMAEATLAVSFAplftgltldvveadalEAENRAVPVPEGDPR--RGTDGVRSF 392
Cdd:PLN03102 313 PAALVKKVQRLGFQ-------VMHAYGLTEATGPVLFC----------------EWQDEWNRLPENQQMelKARQGVSIL 369
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 393 ALlgRPLDGLEAEIVDDAGKrvDEREVGEIRLRGEAVTPGYLTmdGPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRK 469
Cdd:PLN03102 370 GL--ADVDVKNKETQESVPR--DGKTMGEIVIKGSSIMKGYLK--NPKATSEafKHGWLNTGDVGVIhPDGHVEIKDRSK 443
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 470 DVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMkqvsARVRDAVD----- 544
Cdd:PLN03102 444 DIIISGGENISSVEVENVLYKYPKVLETAVVAMPHPTWGETPCAFVVLEKGETTKEDRVDKLV----TRERDLIEycren 519
                        410       420
                 ....*....|....*....|....*.
gi 300790052 545 ----MRPYAVVVLPagSLPKTPSGKV 566
Cdd:PLN03102 520 lphfMCPRKVVFLQ--ELPKNGNGKI 543
PRK07470 PRK07470
acyl-CoA synthetase; Validated
8-578 1.57e-15

acyl-CoA synthetase; Validated


Pssm-ID: 180988 [Multi-domain]  Cd Length: 528  Bit Score: 79.70  E-value: 1.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   8 LVATATKRGQQRGMVTGEpkepVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGS-VTML 86
Cdd:PRK07470  13 LRQAARRFPDRIALVWGD----RSWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGAVwVPTN 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  87 HQPTPrTDLAEWAEdTVRVLGMIGSDqdalGGPGGLAPRPGSGAGPRNVTVLLGEPFdqlapvleqkGIGFQLITELAAA 166
Cdd:PRK07470  89 FRQTP-DEVAYLAE-ASGARAMICHA----DFPEHAAAVRAASPDLTHVVAIGGARA----------GLDYEALVARHLG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 167 EPLPDVVVtDEGDTALLQLTSGSTADPKAVRITYGNL---YSNVKAMVERAEFDFDVDVMVSwlPTFHDMGMVGFLTVPM 243
Cdd:PRK07470 153 ARVANAAV-DHDDPCWFFFTSGTTGRPKAAVLTHGQMafvITNHLADLMPGTTEQDASLVVA--PLSHGAGIHQLCQVAR 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 244 tfGVELVkITPVEFLSGPLIWpELITKYHGTTTaapnFAYAIVGRRMARVDEDDAYDLSKLRIALNGAEPIDETAVQTfv 323
Cdd:PRK07470 230 --GAATV-LLPSERFDPAEVW-ALVERHRVTNL----FTVPTILKMLVEHPAVDRYDHSSLRYVIYAGAPMYRADQKR-- 299
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 324 dagARFKMPAECVfPAYGMAEATLAVSFAPlftgltldvveadalEAENRAVPVPegDPRRGTdgvrsfalLGRPLDGLE 403
Cdd:PRK07470 300 ---ALAKLGKVLV-QYFGLGEVTGNITVLP---------------PALHDAEDGP--DARIGT--------CGFERTGME 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 404 AEIVDDAGKRVDEREVGEIRLRGEAVTPGYLtmDGPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLY 480
Cdd:PRK07470 351 VQIQDDEGRELPPGETGEICVIGPAVFAGYY--NNPEANAKafRDGWFRTGDLGHLdARGFLYITGRASDMYISGGSNVY 428
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 481 PTDIER--------AATSVEGV------RAGNAVAVRLDAGS-RRERFAVVLESKLagdaeaeknlmkqvsARVRdavdm 545
Cdd:PRK07470 429 PREIEEkllthpavSEVAVLGVpdpvwgEVGVAVCVARDGAPvDEAELLAWLDGKV---------------ARYK----- 488
                        570       580       590
                 ....*....|....*....|....*....|...
gi 300790052 546 RPYAVVVLPAgsLPKTPSGKVKRAATAQQFADR 578
Cdd:PRK07470 489 LPKRFFFWDA--LPKSGYGKITKKMVREELEER 519
A_NRPS_Ta1_like cd12116
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...
33-570 1.70e-15

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.


Pssm-ID: 341281 [Multi-domain]  Cd Length: 470  Bit Score: 79.26  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDTVRVLgmigsd 112
Cdd:cd12116   14 SYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYILEDAEPAL------ 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 qdALGGPGGLAPRPGSGAGPRNVTVLLGEPFDQLAPvleqkgigfqlitelaaaEPLPDvvvtdegDTALLQLTSGSTAD 192
Cdd:cd12116   88 --VLTDDALPDRLPAGLPVLLLALAAAAAAPAAPRT------------------PVSPD-------DLAYVIYTSGSTGR 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 193 PKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTvPMTFGVELVkITPVEFLSGPLIWPELITKyH 272
Cdd:cd12116  141 PKGVVVSHRNLVNFLHSMRERLGLGPG-DRLLAVTTYAFDISLLELLL-PLLAGARVV-IAPRETQRDPEALARLIEA-H 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 273 GTTT--AAPnfayaiVGRRMARVDEDDAydLSKLRiALNGAEPIDETAVQTFVDAGArfkmpaeCVFPAYGMAEATLAVS 350
Cdd:cd12116  217 SITVmqATP------ATWRMLLDAGWQG--RAGLT-ALCGGEALPPDLAARLLSRVG-------SLWNLYGPTETTIWST 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 351 faplftgltldvveADALEAENRAVPvpegdprrgtdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVT 430
Cdd:cd12116  281 --------------AARVTAAAGPIP------------------IGRPLANTQVYVLDAALRPVPPGVPGELYIGGDGVA 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 431 PGY-----LT----MDGPLATQDEDgWLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGnAV 500
Cdd:cd12116  329 QGYlgrpaLTaerfVPDPFAGPGSR-LYRTGDLVrRRADGRLEYLGRADGQVKIRGHRIELGEIEAALAAHPGVAQA-AV 406
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 501 AVRLDAGSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAvdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:cd12116  407 VVREDGGDRRLVAYVVLKAGAAPDAAA---LRAHLRATLPAY--MVPSAFVRLDA--LPLTANGKLDRKA 469
PRK08315 PRK08315
AMP-binding domain protein; Validated
396-485 2.73e-15

AMP-binding domain protein; Validated


Pssm-ID: 236236 [Multi-domain]  Cd Length: 559  Bit Score: 78.70  E-value: 2.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVD-DAGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKD 470
Cdd:PRK08315 374 GRALPHLEVKIVDpETGETVPRGEQGELCTRGYSVMKGYWND--PEKTAeaiDADGWMHTGDLAVMdEEGYVNIVGRIKD 451
                         90
                 ....*....|....*
gi 300790052 471 VIIMGGRNLYPTDIE 485
Cdd:PRK08315 452 MIIRGGENIYPREIE 466
caiC PRK08008
putative crotonobetaine/carnitine-CoA ligase; Validated
125-485 2.78e-15

putative crotonobetaine/carnitine-CoA ligase; Validated


Pssm-ID: 181195 [Multi-domain]  Cd Length: 517  Bit Score: 78.57  E-value: 2.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 125 RPGSGAGPRNVtVLLGEPFDQLAPVleqkgIGFQLITELAAAEpLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNL- 203
Cdd:PRK08008 127 QQEDATPLRHI-CLTRVALPADDGV-----SSFTQLKAQQPAT-LCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLr 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 204 ----YSNVKAMVeRAEfdfdvDVMVSWLPTFHdmgmVGF-LTVPM---TFGVELVKitpVEFLSGPLIWPElITKYHGTT 275
Cdd:PRK08008 200 fagyYSAWQCAL-RDD-----DVYLTVMPAFH----IDCqCTAAMaafSAGATFVL---LEKYSARAFWGQ-VCKYRATI 265
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 276 T-AAPnfayAIVGRRMAR--VDEDDAYDLSKLRIALNgaepIDETAVQTFVdagARFKMPaecVFPAYGMAEaTLAvsfa 352
Cdd:PRK08008 266 TeCIP----MMIRTLMVQppSANDRQHCLREVMFYLN----LSDQEKDAFE---ERFGVR---LLTSYGMTE-TIV---- 326
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 353 plftGLTLDvveadaleaenravpvPEGDPRRgtdgvrsFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEavtPG 432
Cdd:PRK08008 327 ----GIIGD----------------RPGDKRR-------WPSIGRPGFCYEAEIRDDHNRPLPAGEIGEICIKGV---PG 376
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300790052 433 YLTMDG----PLATQ---DEDGWLNTGDLGYlVD--GQIVICGRRKDVIIMGGRNLYPTDIE 485
Cdd:PRK08008 377 KTIFKEyyldPKATAkvlEADGWLHTGDTGY-VDeeGFFYFVDRRCNMIKRGGENVSCVELE 437
ABCL cd05958
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...
174-570 3.36e-15

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.


Pssm-ID: 341268 [Multi-domain]  Cd Length: 439  Bit Score: 77.90  E-value: 3.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 174 VTDEGDTALLQLTSGSTADPKAVRitygNLYSNVKAMVE-------RAEFDfdvDVMVSWLPTFHDMGMVGFLTVPMTFG 246
Cdd:cd05958   93 LTASDDICILAFTSGTTGAPKATM----HFHRDPLASADryavnvlRLRED---DRFVGSPPLAFTFGLGGVLLFPFGVG 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 247 ---VELVKITPVEFLSgpliwpeLITKYHGTTTAAPNFAYaivgRRMARVDEDDAYDLSKLRIALNGAEpidetavqtfv 323
Cdd:cd05958  166 asgVLLEEATPDLLLS-------AIARYKPTVLFTAPTAY----RAMLAHPDAAGPDLSSLRKCVSAGE----------- 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 324 dagarfKMPAEcvfpaygMAEATLAVSFAPLFTGLtldvveaDALEAENRAVPVPEGDPRRGTdgvrsfalLGRPLDGLE 403
Cdd:cd05958  224 ------ALPAA-------LHRAWKEATGIPIIDGI-------GSTEMFHIFISARPGDARPGA--------TGKPVPGYE 275
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 404 AEIVDDAGKRVDEREVGEIRLRGEAvtpGYLTMDGPLA-TQDEDGWLNTGDLgYLV--DGQIVICGRRKDVIIMGGRNLY 480
Cdd:cd05958  276 AKVVDDEGNPVPDGTIGRLAVRGPT---GCRYLADKRQrTYVQGGWNITGDT-YSRdpDGYFRHQGRSDDMIVSGGYNIA 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 481 PTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLPagSLPK 560
Cdd:cd05958  352 PPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVVLRPGVIPGPVLARELQDHAKAHI--APYKYPRAIEFVT--ELPR 427
                        410
                 ....*....|
gi 300790052 561 TPSGKVKRAA 570
Cdd:cd05958  428 TATGKLQRFA 437
A_NRPS_PvdJ-like cd17649
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ...
172-570 1.01e-14

non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341304 [Multi-domain]  Cd Length: 450  Bit Score: 76.64  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDT-ALLQLTSGSTADPKAVRITYGNLYSNVKAMVER------------AEFDFDVDVMvSWLPtfhdmgmvgf 238
Cdd:cd17649   87 LLLTHHPRQlAYVIYTSGSTGTPKGVAVSHGPLAAHCQATAERygltpgdrelqfASFNFDGAHE-QLLP---------- 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 239 ltvPMTFGVELVkITPVEFLSGPLIWPELITKyHGTTTAAPNFAYaivGRRMARVDEDDAYDLSK-LRIALNGAEPIDet 317
Cdd:cd17649  156 ---PLICGACVV-LRPDELWASADELAEMVRE-LGVTVLDLPPAY---LQQLAEEADRTGDGRPPsLRLYIFGGEALS-- 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 318 avqtfVDAGARFKMPAECVFPAYGMAEATLAVsfaplftglTLDVVEADALEAENrAVPvpegdprrgtdgvrsfalLGR 397
Cdd:cd17649  226 -----PELLRRWLKAPVRLFNAYGPTEATVTP---------LVWKCEAGAARAGA-SMP------------------IGR 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 398 PLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQ---DEDG-----WLNTGDLG-YLVDGQIVICGRR 468
Cdd:cd17649  273 PLGGRSAYILDADLNPVPVGVTGELYIGGEGLARGYLGRPELTAERfvpDPFGapgsrLYRTGDLArWRDDGVIEYLGRV 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 469 KDVIIMGGRNLYPTDIERAATSVEGVRAGnAVAVRLDAGSRRERFAVVLESKLAGDAEAEKnLMKQVSARVRDAvdMRPY 548
Cdd:cd17649  353 DHQVKIRGFRIELGEIEAALLEHPGVREA-AVVALDGAGGKQLVAYVVLRAAAAQPELRAQ-LRTALRASLPDY--MVPA 428
                        410       420
                 ....*....|....*....|..
gi 300790052 549 AVVVLPagSLPKTPSGKVKRAA 570
Cdd:cd17649  429 HLVFLA--RLPLTPNGKLDRKA 448
PRK08162 PRK08162
acyl-CoA synthetase; Validated
28-487 2.03e-14

acyl-CoA synthetase; Validated


Pssm-ID: 236169 [Multi-domain]  Cd Length: 545  Bit Score: 76.14  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  28 EPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAApvlIAPTVQA---VWLAGGsvtMLHQPTPRTDLA-------- 96
Cdd:PRK08162  40 GDRRRTWAETYARCRRLASALARRGIGRGDTVAVLLPN---IPAMVEAhfgVPMAGA---VLNTLNTRLDAAsiafmlrh 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  97 ----------EWAEDTVRVLGMIGSDQ----DALGGPGGLAPRPGSgagprnvtvLLGEPFdqlapvleqkgigfqlite 162
Cdd:PRK08162 114 geakvlivdtEFAEVAREALALLPGPKplviDVDDPEYPGGRFIGA---------LDYEAF------------------- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 163 LAAAEP-----LPDvvvtDEGDTALLQLTSGSTADPKAV----RITYGNLYSNVKA--MVERAefdfdvdVMVSWLPTFH 231
Cdd:PRK08162 166 LASGDPdfawtLPA----DEWDAIALNYTSGTTGNPKGVvyhhRGAYLNALSNILAwgMPKHP-------VYLWTLPMFH 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 232 DMGMVGFLTVPMTFGVE--LVKITPVeflsgpLIWpELITKyHGTT--TAAPnfayaIVGRRMARVDEDDAydlsklria 307
Cdd:PRK08162 235 CNGWCFPWTVAARAGTNvcLRKVDPK------LIF-DLIRE-HGVThyCGAP-----IVLSALINAPAEWR--------- 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 308 lngaEPIDETaVQTFVdAGArfkMPAECVFPayGMAEATLAVSFAplfTGLTlDV---VEADALEAENRAVPVPEGDPRR 384
Cdd:PRK08162 293 ----AGIDHP-VHAMV-AGA---APPAAVIA--KMEEIGFDLTHV---YGLT-ETygpATVCAWQPEWDALPLDERAQLK 357
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 385 GTDGVRSFALLGrpldgleAEIVD-DAGKRV--DEREVGEIRLRGEAVTPGYLTmdGPLATQD--EDGWLNTGDLGYL-V 458
Cdd:PRK08162 358 ARQGVRYPLQEG-------VTVLDpDTMQPVpaDGETIGEIMFRGNIVMKGYLK--NPKATEEafAGGWFHTGDLAVLhP 428
                        490       500
                 ....*....|....*....|....*....
gi 300790052 459 DGQIVICGRRKDVIIMGGRNLYPTDIERA 487
Cdd:PRK08162 429 DGYIKIKDRSKDIIISGGENISSIEVEDV 457
A_NRPS_Sfm_like cd12115
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ...
33-570 2.03e-14

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.


Pssm-ID: 341280 [Multi-domain]  Cd Length: 447  Bit Score: 75.82  E-value: 2.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmigsd 112
Cdd:cd12115   26 TYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDPAYPPERLRFILED----------- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 113 qdalggpgglaprpgsgAGPRnvtvllgepfdqlapvleqkgigfqlitelaaaeplpdVVVTDEGDTALLQLTSGSTAD 192
Cdd:cd12115   95 -----------------AQAR--------------------------------------LVLTDPDDLAYVIYTSGSTGR 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 193 PKAVRITYGNlysnVKAMVERAEFDFDVDVMVSWL---PTFHDMGmVGFLTVPMTFGVELVkitpveFLSGPLIWPELit 269
Cdd:cd12115  120 PKGVAIEHRN----AAAFLQWAAAAFSAEELAGVLastSICFDLS-VFELFGPLATGGKVV------LADNVLALPDL-- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 270 kyhgtttAAPNFAYAI--VGRRMARVDEDDAYDLSKLRIALNGaEPIDETAVQTFVDagarfKMPAECVFPAYGMAEATL 347
Cdd:cd12115  187 -------PAAAEVTLIntVPSAAAELLRHDALPASVRVVNLAG-EPLPRDLVQRLYA-----RLQVERVVNLYGPSEDTT 253
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 348 AVSFAPLftgltldvveadaleaenravpvpegdpRRGTDGVRSfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGE 427
Cdd:cd12115  254 YSTVAPV----------------------------PPGASGEVS---IGRPLANTQAYVLDRALQPVPLGVPGELYIGGA 302
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 428 AVTPGYLtmDGPLATQDE---DGWL------NTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAG 497
Cdd:cd12115  303 GVARGYL--GRPGLTAERflpDPFGpgarlyRTGDLVrWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREA 380
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300790052 498 NAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQvsarvRDAVDMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:cd12115  381 VVVAIGDAAGERRLVAYIVAEPGAAGLVEDLRRHLGT-----RLPAYMVPSRFVRLDA--LPLTPNGKIDRSA 446
23DHB-AMP_lg cd05920
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...
173-570 2.24e-14

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.


Pssm-ID: 341244 [Multi-domain]  Cd Length: 482  Bit Score: 75.83  E-value: 2.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 173 VVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHdmgmvGF-LTVPMTFGVELVK 251
Cdd:cd05920  134 LAESIPEVALFLLSGGTTGTPKLIPRTHNDYAYNVRASAEVCGLDQD-TVYLAVLPAAH-----NFpLACPGVLGTLLAG 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 252 ITPVefLSG--------PLIWPELITkyhgTTTAAPnfayAIVGRRMARVDEDDAyDLSKLRIALNGAEPIDETAVQtfv 323
Cdd:cd05920  208 GRVV--LAPdpspdaafPLIEREGVT----VTALVP----ALVSLWLDAAASRRA-DLSSLRLLQVGGARLSPALAR--- 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 324 DAGARFKMPAECVFpayGMAEATLAvsfaplFTGLtldvveadaleaenravpvpeGDPrrgtdGVRSFALLGRPLDGL- 402
Cdd:cd05920  274 RVPPVLGCTLQQVF---GMAEGLLN------YTRL---------------------DDP-----DEVIIHTQGRPMSPDd 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 403 EAEIVDDAGKRVDEREVGEIRLRGEAVTPGYltMDGPLATQ---DEDGWLNTGDLGYLV-DGQIVICGRRKDVIIMGGRN 478
Cdd:cd05920  319 EIRVVDEEGNPVPPGEEGELLTRGPYTIRGY--YRAPEHNArafTPDGFYRTGDLVRRTpDGYLVVEGRIKDQINRGGEK 396
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 479 LYPTDIERAATSVEGVRAGNAVAV-RLDAGSRRERFAVVLESKLaGDAEAEKNLMKQVSARVRdavdmRPYAVVVLPagS 557
Cdd:cd05920  397 IAAEEVENLLLRHPAVHDAAVVAMpDELLGERSCAFVVLRDPPP-SAAQLRRFLRERGLAAYK-----LPDRIEFVD--S 468
                        410
                 ....*....|...
gi 300790052 558 LPKTPSGKVKRAA 570
Cdd:cd05920  469 LPLTAVGKIDKKA 481
PRK07787 PRK07787
acyl-CoA synthetase; Validated
176-573 3.16e-14

acyl-CoA synthetase; Validated


Pssm-ID: 236096 [Multi-domain]  Cd Length: 471  Bit Score: 75.03  E-value: 3.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 176 DEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFG---VELVKI 252
Cdd:PRK07787 126 DPDAPALIVYTSGTTGPPKGVVLSRRAIAADLDALAEAWQWTAD-DVLVHGLPLFHVHGLVLGVLGPLRIGnrfVHTGRP 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 253 TPVEFLSGpliwpeliTKYHGTTTaapnFAYAIVGRRMARvDEDDAYDLSKLRIALNGAEPIDETAVQTFVDAGARfkMP 332
Cdd:PRK07787 205 TPEAYAQA--------LSEGGTLY----FGVPTVWSRIAA-DPEAARALRGARLLVSGSAALPVPVFDRLAALTGH--RP 269
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 333 AEcvfpAYGMAEATLAVSfaplftgltldvVEADaleaenravpvpeGDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGK 412
Cdd:PRK07787 270 VE----RYGMTETLITLS------------TRAD-------------GERRPGW--------VGLPLAGVETRLVDEDGG 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 413 RV--DEREVGEIRLRGEAVTPGYLTM-DGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRK-DVIIMGGRNLYPTDIERA 487
Cdd:PRK07787 313 PVphDGETVGELQVRGPTLFDGYLNRpDATAAAFTADGWFRTGDVAVVdPDGMHRIVGREStDLIKSGGYRIGAGEIETA 392
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 488 ATSVEGVRAGNAVAV-RLDAGSRRERFAVvlesklAGDAEAEKNLMKQVSARVrdAVDMRPYAVVVLPAgsLPKTPSGKV 566
Cdd:PRK07787 393 LLGHPGVREAAVVGVpDDDLGQRIVAYVV------GADDVAADELIDFVAQQL--SVHKRPREVRFVDA--LPRNAMGKV 462

                 ....*..
gi 300790052 567 KRAATAQ 573
Cdd:PRK07787 463 LKKQLLS 469
A_NRPS_TlmIV_like cd12114
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...
33-570 4.29e-14

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.


Pssm-ID: 341279 [Multi-domain]  Cd Length: 477  Bit Score: 74.61  E-value: 4.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPV--LIAptVQAVWLAGGSVTML--HQPTPRTD--LAEWAEDTVRVL 106
Cdd:cd12114   14 TYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPeqVVA--VLGILAAGAAYVPVdiDQPAARREaiLADAGARLVLTD 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 107 GMIgsdqdalggpgglaprpgsgagprnvTVLLGEPFDQLAPVLEqkgigfqliteLAAAEPLPDVVVTDEGDTALLQLT 186
Cdd:cd12114   92 GPD--------------------------AQLDVAVFDVLILDLD-----------ALAAPAPPPPVDVAPDDLAYVIFT 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 187 SGSTADPKAVRITYGNLYSNVKAMVER------------AEFDFDvdvmvswLPTFHDMGmvgfltvPMTFGVELVKITP 254
Cdd:cd12114  135 SGSTGTPKGVMISHRAALNTILDINRRfavgpddrvlalSSLSFD-------LSVYDIFG-------ALSAGATLVLPDE 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 255 VEfLSGPLIWPELITKyHGTTtaAPNFAYAIVGRRMArVDEDDAYDLSKLRIALNGAEPIDetavqtfVDAGARFK--MP 332
Cdd:cd12114  201 AR-RRDPAHWAELIER-HGVT--LWNSVPALLEMLLD-VLEAAQALLPSLRLVLLSGDWIP-------LDLPARLRalAP 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 333 AECVFPAYGMAEATLAVSFAPLftgltldvveaDALEAENRAVPvpegdprrgtdgvrsfalLGRPLDGLEAEIVDDAGK 412
Cdd:cd12114  269 DARLISLGGATEASIWSIYHPI-----------DEVPPDWRSIP------------------YGRPLANQRYRVLDPRGR 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 413 RVDEREVGEIRLRGEAVTPGYLtmDGPLATQ-----DEDG--WLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDI 484
Cdd:cd12114  320 DCPDWVPGELWIGGRGVALGYL--GDPELTAarfvtHPDGerLYRTGDLGrYRPDGTLEFLGRRDGQVKVRGYRIELGEI 397
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 485 ERAATSVEGVRAGNAVAVRlDAGSRRERFAVVLESKLAGDAEAEknLMKQVSARVRDAvdMRPYAVVVLPAgsLPKTPSG 564
Cdd:cd12114  398 EAALQAHPGVARAVVVVLG-DPGGKRLAAFVVPDNDGTPIAPDA--LRAFLAQTLPAY--MIPSRVIALEA--LPLTANG 470

                 ....*.
gi 300790052 565 KVKRAA 570
Cdd:cd12114  471 KVDRAA 476
Dip2 cd05905
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of ...
175-575 4.45e-14

Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of the adenylate forming enzyme family, including insect luciferase, acetyl CoA ligases and the adenylation domain of nonribosomal peptide synthetases (NRPS). However, its function may have diverged from other members of the superfamily. In mouse embryo, Dip2 homolog A plays an important role in the development of both vertebrate and invertebrate nervous systems. Dip2A appears to regulate cell growth and the arrangement of cells in organs. Biochemically, Dip2A functions as a receptor of FSTL1, an extracellular glycoprotein, and may play a role as a cardiovascular protective agent.


Pssm-ID: 341231 [Multi-domain]  Cd Length: 571  Bit Score: 75.08  E-value: 4.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 175 TDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMV-GFLTVPMTfGVELVKIT 253
Cdd:cd05905  146 TRDGDTAYIEYSFSSDGSLSGVAVSHSSLLAHCRALKEACELYES-RPLVTVLDFKSGLGLWhGCLLSVYS-GHHTILIP 223
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 254 PVEFLSGPLIWPELITKYHGTTTAAP-NFAYAIVGRRMARVDEDDAYD--LSKLRIALNGAE-PIDETAVQTFVDAGARF 329
Cdd:cd05905  224 PELMKTNPLLWLQTLSQYKVRDAYVKlRTLHWCLKDLSSTLASLKNRDvnLSSLRMCMVPCEnRPRISSCDSFLKLFQTL 303
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 330 KMPAECVFPAYGmaeaTLAVSF----APLFTGLTLDVVEADALEaENRAVPVPEGDPRRGT--DGvrsfallGRPLDGLE 403
Cdd:cd05905  304 GLSPRAVSTEFG----TRVNPFicwqGTSGPEPSRVYLDMRALR-HGVVRLDERDKPNSLPlqDS-------GKVLPGAQ 371
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 404 AEIVDDAGK---RVDEreVGEIRLRGEAVTPGYLTMDGPLATQDED-------------GWLNTGDLGYLVDGQIV---- 463
Cdd:cd05905  372 VAIVNPETKglcKDGE--IGEIWVNSPANASGYFLLDGETNDTFKVfpstrlstgitnnSYARTGLLGFLRPTKCTdlnv 449
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 464 -------ICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAvrldagSRRERFAVVLESKLAGDAEAeKNLMKQVS 536
Cdd:cd05905  450 eehdllfVVGSIDETLEVRGLRHHPSDIEATVMRVHPYRGRCAVF------SITGLVVVVAEQPPGSEEEA-LDLVPLVL 522
                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 300790052 537 ARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKRAATAQQF 575
Cdd:cd05905  523 NAILEEHQVIVDCVALVPPGSLPKNPLGEKQRMEIRQAF 561
PRK13383 PRK13383
acyl-CoA synthetase; Provisional
395-568 4.65e-14

acyl-CoA synthetase; Provisional


Pssm-ID: 139531 [Multi-domain]  Cd Length: 516  Bit Score: 75.03  E-value: 4.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATqdeDGWLNTGDLGYLVD-GQIVICGRRKDVII 473
Cdd:PRK13383 347 VGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKAVV---DGMTSTGDMGYLDNaGRLFIVGREDDMII 423
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 474 MGGRNLYPTDIERAATSVEGVrAGNAVAVRLDA--GSRRERFaVVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAvv 551
Cdd:PRK13383 424 SGGENVYPRAVENALAAHPAV-ADNAVIGVPDErfGHRLAAF-VVLHPGSGVDAAQLRDYLKDRVSRFEQPRDINIVS-- 499
                        170
                 ....*....|....*..
gi 300790052 552 vlpagSLPKTPSGKVKR 568
Cdd:PRK13383 500 -----SIPRNPTGKVLR 511
ACSBG_like cd05933
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ...
33-487 5.31e-14

Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341256 [Multi-domain]  Cd Length: 596  Bit Score: 74.70  E-value: 5.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLA--AAPVLIApTVQAVwLAGGSVTMLHqPTPRTD----LAEWAE------ 100
Cdd:cd05933   10 TYKEYYEACRQAAKAFLKLGLERFHGVGILGfnSPEWFIA-AVGAI-FAGGIAVGIY-TTNSPEacqyVAETSEanilvv 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 101 DTVRVLGMIGSDQDALggpgglaprpgsgagPR-NVTVLLGEPFDQLAPVLeqkgIGFQLITELAAAEP---LPDVVVTD 176
Cdd:cd05933   87 ENQKQLQKILQIQDKL---------------PHlKAIIQYKEPLKEKEPNL----YSWDEFMELGRSIPdeqLDAIISSQ 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 177 E-GDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVD---VMVSWLPTFHDMGMVGFLTVPMTFG------ 246
Cdd:cd05933  148 KpNQCCTLIYTSGTTGMPKGVMLSHDNITWTAKAASQHMDLRPATVgqeSVVSYLPLSHIAAQILDIWLPIKVGgqvyfa 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 247 ---------VE-LVKITPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRRMARVDEDDAYD---------------- 300
Cdd:cd05933  228 qpdalkgtlVKtLREVRPTAFMGVPRVWEKIQEKMKAVGAKSGTLKRKIASWAKGVGLETNLKLmggespsplfyrlakk 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 301 --LSKLRIAL---------NGAEPIDETAVQTFVDAGARfkmpaecVFPAYGMAEATlavsfAPLFtgltldvveadale 369
Cdd:cd05933  308 lvFKKVRKALgldrcqkffTGAAPISRETLEFFLSLNIP-------IMELYGMSETS-----GPHT-------------- 361
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 370 aenraVPVPEgdprrgtdgvrSFALL--GRPLDGLEAEIVDDagkrvDEREVGEIRLRGEAVTPGYLTM-DGPLATQDED 446
Cdd:cd05933  362 -----ISNPQ-----------AYRLLscGKALPGCKTKIHNP-----DADGIGEICFWGRHVFMGYLNMeDKTEEAIDED 420
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 300790052 447 GWLNTGDLGYL-VDGQIVICGRRKDVIIM-GGRNLYPTDIERA 487
Cdd:cd05933  421 GWLHSGDLGKLdEDGFLYITGRIKELIITaGGENVPPVPIEDA 463
PRK08751 PRK08751
long-chain fatty acid--CoA ligase;
155-568 5.58e-14

long-chain fatty acid--CoA ligase;


Pssm-ID: 181546 [Multi-domain]  Cd Length: 560  Bit Score: 74.91  E-value: 5.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 155 IGFQLITELAAAEPLPDVVVTDEgDTALLQLTSGSTADPKAVRITYGNLYSNVKA----MVERAEFDFDVDVMVSWLPTF 230
Cdd:PRK08751 186 IRFREALALGRKHSMPTLQIEPD-DIAFLQYTGGTTGVAKGAMLTHRNLVANMQQahqwLAGTGKLEEGCEVVITALPLY 264
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 231 HDMGMVGFLTVPMTFGvelvkiTPVEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGRrMARVDEDDAYDLSKLRIALNG 310
Cdd:PRK08751 265 HIFALTANGLVFMKIG------GCNHLISNPRDMPGFVKELKKTRFTAFTGVNTLFNG-LLNTPGFDQIDFSSLKMTLGG 337
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 311 AepideTAVQTFVdAGARFKMPAECVFPAYGMAEATLAVSFAPLftgltldvveadALEAENRAVpvpegdprrgtdgvr 390
Cdd:PRK08751 338 G-----MAVQRSV-AERWKQVTGLTLVEAYGLTETSPAACINPL------------TLKEYNGSI--------------- 384
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 391 sfallGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLAT-QDEDGWLNTGDLGYL-VDGQIVICGRR 468
Cdd:PRK08751 385 -----GLPIPSTDACIKDDAGTVLAIGEIGELCIKGPQVMKGYWKRPEETAKvMDADGWLHTGDIARMdEQGFVYIVDRK 459
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 469 KDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRlDAGSRRERFAVVLESKLAGDAEaeknlmkQVSARVRDAVDMRPY 548
Cdd:PRK08751 460 KDMILVSGFNVYPNEIEDVIAMMPGVLEVAAVGVP-DEKSGEIVKVVIVKKDPALTAE-------DVKAHARANLTGYKQ 531
                        410       420
                 ....*....|....*....|
gi 300790052 549 AVVVLPAGSLPKTPSGKVKR 568
Cdd:PRK08751 532 PRIIEFRKELPKTNVGKILR 551
LC-FACS_euk cd05927
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...
179-471 6.92e-14

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.


Pssm-ID: 341250 [Multi-domain]  Cd Length: 545  Bit Score: 74.56  E-value: 6.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAM---VERAEFDFDVDVMVSWLP------------TFHDMGMVGFLTVPM 243
Cdd:cd05927  115 DLATICYTSGTTGNPKGVMLTHGNIVSNVAGVfkiLEILNKINPTDVYISYLPlahifervvealFLYHGAKIGFYSGDI 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 244 TFGVELVKI-TPVEFLSGPLIWPELITKYHGTTTAAP-------NFAYAIVGRRMARVDED-----DAYDLSK------- 303
Cdd:cd05927  195 RLLLDDIKAlKPTVFPGVPRVLNRIYDKIFNKVQAKGplkrklfNFALNYKLAELRSGVVRaspfwDKLVFNKikqalgg 274
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 304 -LRIALNGAEPIDETaVQTFVDAgarfkMPAECVFPAYGMAEaTLAVSFaplftgLTLdvveadaleaenravpvpEGDP 382
Cdd:cd05927  275 nVRLMLTGSAPLSPE-VLEFLRV-----ALGCPVLEGYGQTE-CTAGAT------LTL------------------PGDT 323
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 383 RRGTdgvrsfalLGRPLDGLEAEIVD------DAGKRVDErevGEIRLRGEAVTPGYLtmDGPLATQ---DEDGWLNTGD 453
Cdd:cd05927  324 SVGH--------VGGPLPCAEVKLVDvpemnyDAKDPNPR---GEVCIRGPNVFSGYY--KDPEKTAealDEDGWLHTGD 390
                        330
                 ....*....|....*....
gi 300790052 454 LG-YLVDGQIVICGRRKDV 471
Cdd:cd05927  391 IGeWLPNGTLKIIDRKKNI 409
PRK07059 PRK07059
Long-chain-fatty-acid--CoA ligase; Validated
178-502 7.10e-14

Long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235923 [Multi-domain]  Cd Length: 557  Bit Score: 74.29  E-value: 7.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 178 GDTALLQLTSGSTADPKAVRITYGNLYSNVKAM------VERAEFDFDVDVMVSWLPTFHDMGM-VGFLTVPMTFGVELV 250
Cdd:PRK07059 204 DDVAFLQYTGGTTGVSKGATLLHRNIVANVLQMeawlqpAFEKKPRPDQLNFVCALPLYHIFALtVCGLLGMRTGGRNIL 283
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 251 KITP------VEFLSG--PLIWPELITKYHGTTTAaPNFayaivgrrmarvdedDAYDLSKLRIALNGAepideTAVQTF 322
Cdd:PRK07059 284 IPNPrdipgfIKELKKyqVHIFPAVNTLYNALLNN-PDF---------------DKLDFSKLIVANGGG-----MAVQRP 342
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 323 VdAGARFKMPAECVFPAYGMAEAtlavsfAPLFTGLTLDVVEADaleaenravpvpegdprrGTdgvrsfalLGRPLDGL 402
Cdd:PRK07059 343 V-AERWLEMTGCPITEGYGLSET------SPVATCNPVDATEFS------------------GT--------IGLPLPST 389
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 403 EAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLA-TQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLY 480
Cdd:PRK07059 390 EVSIRDDDGNDLPLGEPGEICIRGPQVMAGYWNRPDETAkVMTADGFFRTGDVGVMdERGYTKIVDRKKDMILVSGFNVY 469
                        330       340
                 ....*....|....*....|..
gi 300790052 481 PTDIERAATSVEGVRAGNAVAV 502
Cdd:PRK07059 470 PNEIEEVVASHPGVLEVAAVGV 491
A_NRPS_CmdD_like cd17652
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...
170-570 9.15e-14

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).


Pssm-ID: 341307 [Multi-domain]  Cd Length: 436  Bit Score: 73.44  E-value: 9.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 170 PDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERaefdFDVDVMVSWLpTFHDMGM-VGFLTVPMTF--G 246
Cdd:cd17652   85 PALLLTTPDNLAYVIYTSGSTGRPKGVVVTHRGLANLAAAQIAA----FDVGPGSRVL-QFASPSFdASVWELLMALlaG 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 247 VELVKITPVEFLSG-PLIwpELITKYHGTTTAAPNFAYAIVgrrmarvdedDAYDLSKLRIALNGAEPIDETAVQTFVda 325
Cdd:cd17652  160 ATLVLAPAEELLPGePLA--DLLREHRITHVTLPPAALAAL----------PPDDLPDLRTLVVAGEACPAELVDRWA-- 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 326 garfkmPAECVFPAYGMAEATLAVSFAPLFTGltldvveadaleaeNRAVPVpegdprrgtdgvrsfallGRPLDGLEAE 405
Cdd:cd17652  226 ------PGRRMINAYGPTETTVCATMAGPLPG--------------GGVPPI------------------GRPVPGTRVY 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 406 IVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQ--------DEDGWLNTGDLG-YLVDGQIVICGRRKDVIIMGG 476
Cdd:cd17652  268 VLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAERfvadpfgaPGSRMYRTGDLArWRADGQLEFLGRADDQVKIRG 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 477 RNLYPTDIERAATSVEGVRAGnAVAVRLDAGSRRERFAVVLESklAGDAEAEKNLMKQVSARVRDAvdMRPYAVVVLPAg 556
Cdd:cd17652  348 FRIELGEVEAALTEHPGVAEA-VVVVRDDRPGDKRLVAYVVPA--PGAAPTAAELRAHLAERLPGY--MVPAAFVVLDA- 421
                        410
                 ....*....|....
gi 300790052 557 sLPKTPSGKVKRAA 570
Cdd:cd17652  422 -LPLTPNGKLDRRA 434
BACL_like cd05929
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...
164-568 9.59e-14

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.


Pssm-ID: 341252 [Multi-domain]  Cd Length: 473  Bit Score: 73.57  E-value: 9.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 164 AAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERA---EFDFDvDVMVSWLPTFHDMGMVGFLT 240
Cdd:cd05929  111 AAEGGSPETPIEDEAAGWKMLYSGGTTGRPKGIKRGLPGGPPDNDTLMAAAlgfGPGAD-SVYLSPAPLYHAAPFRWSMT 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 241 VPMTFG--VELVKITPVEFLsgpliwpELITKYHGTTTaapNFAYAIVgRRMARVDED--DAYDLSKLRIALNGAEPIDE 316
Cdd:cd05929  190 ALFMGGtlVLMEKFDPEEFL-------RLIERYRVTFA---QFVPTMF-VRLLKLPEAvrNAYDLSSLKRVIHAAAPCPP 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 317 TAVQTFVDAGArfkmpaECVFPAYGMAEATlavsfaplftGLTLdvveadaleaenravpvpegdpRRGTDGVRSFALLG 396
Cdd:cd05929  259 WVKEQWIDWGG------PIIWEYYGGTEGQ----------GLTI----------------------INGEEWLTHPGSVG 300
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 397 RPLDGlEAEIVDDAGKRVDEREVGEIRLRGeavTPGYLTMDGPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKDVI 472
Cdd:cd05929  301 RAVLG-KVHILDEDGNEVPPGEIGEVYFAN---GPGFEYTNDPEKTAaarNEGGWSTLGDVGYLdEDGYLYLTDRRSDMI 376
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 473 IMGGRNLYPTDIERAATSVEGVRAGNAVAVRlDAGSRRERFAVV--LESKLAGDAEAE-------KNLMKQVSARVRDAV 543
Cdd:cd05929  377 ISGGVNIYPQEIENALIAHPKVLDAAVVGVP-DEELGQRVHAVVqpAPGADAGTALAEeliaflrDRLSRYKCPRSIEFV 455
                        410       420
                 ....*....|....*....|....*
gi 300790052 544 DmrpyavvvlpagSLPKTPSGKVKR 568
Cdd:cd05929  456 A------------ELPRDDTGKLYR 468
PRK06334 PRK06334
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
176-476 1.35e-13

long chain fatty acid--[acyl-carrier-protein] ligase; Validated


Pssm-ID: 180533 [Multi-domain]  Cd Length: 539  Bit Score: 73.31  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 176 DEGDTALLQLTSGSTADPKAVRITYGNLYSNvkamvERAEFDF----DVDVMVSWLPTFHDMGMVGFLTVPMTFGVelvk 251
Cdd:PRK06334 181 DPEDVAVILFTSGTEKLPKGVPLTHANLLAN-----QRACLKFfspkEDDVMMSFLPPFHAYGFNSCTLFPLLSGV---- 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 252 itPVEFLSGPLiWP----ELITKYHGT-TTAAPNFAYAIVgrRMARVDEDdayDLSKLRIALNGAEPIDETAVQtfvdaG 326
Cdd:PRK06334 252 --PVVFAYNPL-YPkkivEMIDEAKVTfLGSTPVFFDYIL--KTAKKQES---CLPSLRFVVIGGDAFKDSLYQ-----E 318
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 327 ARFKMPAECVFPAYGMAEATlavsfaPLFTGLTldvveadaleaenravpvpEGDPRRGTdgvrsfaLLGRPLDGLEAEI 406
Cdd:PRK06334 319 ALKTFPHIQLRQGYGTTECS------PVITINT-------------------VNSPKHES-------CVGMPIRGMDVLI 366
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300790052 407 VDDAGK-RVDEREVGEIRLRGEAVTPGYLTMD--GPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGG 476
Cdd:PRK06334 367 VSEETKvPVSSGETGLVLTRGTSLFSGYLGEDfgQGFVELGGETWYVTGDLGYVdRHGELFLKGRLSRFVKIGA 440
PRK08314 PRK08314
long-chain-fatty-acid--CoA ligase; Validated
33-566 1.65e-13

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236235 [Multi-domain]  Cd Length: 546  Bit Score: 73.07  E-value: 1.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  33 TWAEVHEEARRIAGGLV-AGGFERGTAVGVLAA-APVLIApTVQAVWLAGGSVTMLHqPTPRTD-LAEWAEDTVRVLGMI 109
Cdd:PRK08314  37 SYRELLEEAERLAGYLQqECGVRKGDRVLLYMQnSPQFVI-AYYAILRANAVVVPVN-PMNREEeLAHYVTDSGARVAIV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 110 GSDQ----DALGGPGGLAP---RPGSGAGPRNVTVLLGEPFDQLAPVLEQKGIGFQLITE-LAAAEPLPDVVVTDEgDTA 181
Cdd:PRK08314 115 GSELapkvAPAVGNLRLRHvivAQYSDYLPAEPEIAVPAWLRAEPPLQALAPGGVVAWKEaLAAGLAPPPHTAGPD-DLA 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 182 LLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITpveflsgp 261
Cdd:PRK08314 194 VLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPE-SVVLAVLPLFHVTGMVHSMNAPIYAGATVVLMP-------- 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 262 lIW-----PELITKYHGTT-----------TAAPNFAyaivgrrmarvdeddAYDLSKLR-IALNGAEPIDETAVQTFVD 324
Cdd:PRK08314 265 -RWdreaaARLIERYRVTHwtniptmvvdfLASPGLA---------------ERDLSSLRyIGGGGAAMPEAVAERLKEL 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 325 AGARFkmpaecvFPAYGMAEaTLAVSFAplftgltldvveadaleaeNravpvPEGDPRRGTdgvrsfalLGRPLDGLEA 404
Cdd:PRK08314 329 TGLDY-------VEGYGLTE-TMAQTHS-------------------N-----PPDRPKLQC--------LGIPTFGVDA 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 405 EIVD-DAGKRVDEREVGEIRLRGEAVTPGYltMDGPLATQDE----DG--WLNTGDLGYL-VDGQIVICGRRKDVIIMGG 476
Cdd:PRK08314 369 RVIDpETLEELPPGEVGEIVVHGPQVFKGY--WNRPEATAEAfieiDGkrFFRTGDLGRMdEEGYFFITDRLKRMINASG 446
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 477 RNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEknlmkQVSARVRDavDMRPYAV--VVLP 554
Cdd:PRK08314 447 FKVWPAEVENLLYKHPAIQEACVIATPDPRRGETVKAVVVLRPEARGKTTEE-----EIIAWARE--HMAAYKYprIVEF 519
                        570
                 ....*....|..
gi 300790052 555 AGSLPKTPSGKV 566
Cdd:PRK08314 520 VDSLPKSGSGKI 531
PRK12467 PRK12467
peptide synthase; Provisional
31-585 2.19e-13

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 73.66  E-value: 2.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   31 RRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDT-VRVLgmi 109
Cdd:PRK12467  537 VLSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEYPQDRLAYMLDDSgVRLL--- 613
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  110 gsdqdaLGGPGGLAPRPGsgagPRNVTVLlgePFDQLAPVLEQKgigfqlitelaaAEPLPDVVVtDEGDTALLQLTSGS 189
Cdd:PRK12467  614 ------LTQSHLLAQLPV----PAGLRSL---CLDEPADLLCGY------------SGHNPEVAL-DPDNLAYVIYTSGS 667
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  190 TADPKAVRITYGNLYSNVKAMVERaeFDFDVDVMVSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEFLSGPLIWPELIT 269
Cdd:PRK12467  668 TGQPKGVAISHGALANYVCVIAER--LQLAADDSMLMVSTFAFDLGVTELFGALASGATLHLLPPDCARDAEAFAALMAD 745
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  270 kyHGTTTAAPNFAYAIVGRRMARVDEDdaydlSKLRIALNGAEPIDETAVQTFVDAGarfkmPAECVFPAYGMAEATLAV 349
Cdd:PRK12467  746 --QGVTVLKIVPSHLQALLQASRVALP-----RPQRALVCGGEALQVDLLARVRALG-----PGARLINHYGPTETTVGV 813
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  350 SFAPLftgltldvveaDALEAENRAVPvpegdprrgtdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAV 429
Cdd:PRK12467  814 STYEL-----------SDEERDFGNVP------------------IGQPLANLGLYILDHYLNPVPVGVVGELYIGGAGL 864
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  430 TPGYLTMDG---------PLATQDEDGWlNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRagNA 499
Cdd:PRK12467  865 ARGYHRRPAltaerfvpdPFGADGGRLY-RTGDLArYRADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVR--EA 941
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  500 VAVRLDAGSRRERFAVVLESKLAGDAE-AEKNLMKQVSARVRDAVDMRPYAVVVLpaGSLPKTPSGKVKRAATAQQFADR 578
Cdd:PRK12467  942 VVLAQPGDAGLQLVAYLVPAAVADGAEhQATRDELKAQLRQVLPDYMVPAHLLLL--DSLPLTPNGKLDRKALPKPDASA 1019

                  ....*..
gi 300790052  579 IKKNADA 585
Cdd:PRK12467 1020 VQATFVA 1026
PRK07786 PRK07786
long-chain-fatty-acid--CoA ligase; Validated
385-576 2.24e-13

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 169098 [Multi-domain]  Cd Length: 542  Bit Score: 72.89  E-value: 2.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 385 GTDGVRSFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYltMDGPLATQD--EDGWLNTGDLGYL-VDGQ 461
Cdd:PRK07786 337 GEDAIRKLGSVGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGY--WNNPEATAEafAGGWFHSGDLVRQdEEGY 414
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 462 IVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRagnAVAVrldAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRD 541
Cdd:PRK07786 415 VWVVDRKKDMIISGGENIYCAEVENVLASHPDIV---EVAV---IGRADEKWGEVPVAVAAVRNDDAALTLEDLAEFLTD 488
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 300790052 542 --AVDMRPYAVVVLPAgsLPKTPSGKVKRAATAQQFA 576
Cdd:PRK07786 489 rlARYKHPKALEIVDA--LPRNPAGKVLKTELRERYG 523
PRK09088 PRK09088
acyl-CoA synthetase; Validated
396-569 2.59e-13

acyl-CoA synthetase; Validated


Pssm-ID: 181644 [Multi-domain]  Cd Length: 488  Bit Score: 72.53  E-value: 2.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYltMDGPLATQ---DEDGWLNTGDLGYL-VDGQIVICGRRKDV 471
Cdd:PRK09088 309 GIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGY--WRRPQATArafTGDGWFRTGDIARRdADGFFWVVDRKKDM 386
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 472 IIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEaekNLMKQVSARVrdAVDMRPYAVV 551
Cdd:PRK09088 387 FISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYLAIVPADGAPLDLE---RIRSHLSTRL--AKYKVPKHLR 461
                        170
                 ....*....|....*...
gi 300790052 552 VLPAgsLPKTPSGKVKRA 569
Cdd:PRK09088 462 LVDA--LPRTASGKLQKA 477
LC_FACS_euk1 cd17639
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ...
173-472 5.11e-13

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.


Pssm-ID: 341294 [Multi-domain]  Cd Length: 507  Bit Score: 71.48  E-value: 5.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 173 VVTDEG--DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVER-AEFDFDVDVMVSWLPTFHDM------------GMVG 237
Cdd:cd17639   81 IFTDGKpdDLACIMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRvPELLGPDDRYLAYLPLAHIFelaaenvclyrgGTIG 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 238 F-----LTVPMTFGV--ELVKITPVEFLSGPLIWpELITKYHGTTTAAPNF--------AYAivgRRMARVDEddAYDL- 301
Cdd:cd17639  161 YgsprtLTDKSKRGCkgDLTEFKPTLMVGVPAIW-DTIRKGVLAKLNPMGGlkrtlfwtAYQ---SKLKALKE--GPGTp 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 302 ---------------SKLRIALNGAEPIDEtAVQTFVdagarfKMPAECVFPAYGMAEaTLAvsfaplftgltldvvead 366
Cdd:cd17639  235 lldelvfkkvraalgGRLRYMLSGGAPLSA-DTQEFL------NIVLCPVIQGYGLTE-TCA------------------ 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 367 aleaeNRAVPVPeGDPRRGTdgvrsfalLGRPLDGLEAEIVD--DAGKRVDEREV-GEIRLRGEAVTPGYLtmDGPLATQ 443
Cdd:cd17639  289 -----GGTVQDP-GDLETGR--------VGPPLPCCEIKLVDweEGGYSTDKPPPrGEILIRGPNVFKGYY--KNPEKTK 352
                        330       340       350
                 ....*....|....*....|....*....|...
gi 300790052 444 ---DEDGWLNTGDLGYLV-DGQIVICGRRKDVI 472
Cdd:cd17639  353 eafDGDGWFHTGDIGEFHpDGTLKIIDRKKDLV 385
PLN02479 PLN02479
acetate-CoA ligase
28-568 5.92e-13

acetate-CoA ligase


Pssm-ID: 178097 [Multi-domain]  Cd Length: 567  Bit Score: 71.41  E-value: 5.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  28 EPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVlaaapvlIAPTVQAVWLAGGSVTM-----------LHQPTPRTDLA 96
Cdd:PLN02479  42 GSVRYTWAQTYQRCRRLASALAKRSIGPGSTVAV-------IAPNIPAMYEAHFGVPMagavvncvnirLNAPTIAFLLE 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  97 EWAEDTVRVlgmigsDQD----ALGGPGGLAPRPGSGAGPRNVTVLLGEPFD--QLAPVLEQKGIGFQ--LIT---ELAA 165
Cdd:PLN02479 115 HSKSEVVMV------DQEfftlAEEALKILAEKKKSSFKPPLLIVIGDPTCDpkSLQYALGKGAIEYEkfLETgdpEFAW 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 166 AEPlpdvvvTDEGDTALLQLTSGSTADPKAVRITYGNLYsnVKAMVERAEFDFDVDVMVSW-LPTFHDMGMVGFLTVPMT 244
Cdd:PLN02479 189 KPP------ADEWQSIALGYTSGTTASPKGVVLHHRGAY--LMALSNALIWGMNEGAVYLWtLPMFHCNGWCFTWTLAAL 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 245 FG--VELVKITPVEFLSGpliwpelITKYhGTT--TAAPNFAYAIVGRRMarvdEDDAYDLSKL-RIALNGAEPiDETAV 319
Cdd:PLN02479 261 CGtnICLRQVTAKAIYSA-------IANY-GVThfCAAPVVLNTIVNAPK----SETILPLPRVvHVMTAGAAP-PPSVL 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 320 QTFVDAGARfkmpaecVFPAYGMAEA---TLAVSFAPlftgltldvvEADALEAENRAvpvpegdPRRGTDGVRSFALLG 396
Cdd:PLN02479 328 FAMSEKGFR-------VTHTYGLSETygpSTVCAWKP----------EWDSLPPEEQA-------RLNARQGVRYIGLEG 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 397 rpLDgleaeIVD-DAGKRV--DEREVGEIRLRGEAVTPGYLtmDGPLATQD--EDGWLNTGDLGYL-VDGQIVICGRRKD 470
Cdd:PLN02479 384 --LD-----VVDtKTMKPVpaDGKTMGEIVMRGNMVMKGYL--KNPKANEEafANGWFHSGDLGVKhPDGYIEIKDRSKD 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 471 VIIMGGRNLYPTDIERAATSVEGVRAGNAVAvRLDagsrrERFA------VVLESKLAGDAEA--EKNLMKqvSARVRDA 542
Cdd:PLN02479 455 IIISGGENISSLEVENVVYTHPAVLEASVVA-RPD-----ERWGespcafVTLKPGVDKSDEAalAEDIMK--FCRERLP 526
                        570       580
                 ....*....|....*....|....*.
gi 300790052 543 VDMRPYAVVVlpaGSLPKTPSGKVKR 568
Cdd:PLN02479 527 AYWVPKSVVF---GPLPKTATGKIQK 549
ACLS-CaiC cd17637
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...
221-568 7.19e-13

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341292 [Multi-domain]  Cd Length: 333  Bit Score: 69.99  E-value: 7.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 221 DVMVSWLPTFHDMGMVGFLTVPMTFGVELV--KITPVEFLsgpliwpELITKYHGTTTAApnFAyAIVGRRMARVDEDDa 298
Cdd:cd17637   42 DVYLNMLPLFHIAGLNLALATFHAGGANVVmeKFDPAEAL-------ELIEEEKVTLMGS--FP-PILSNLLDAAEKSG- 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 299 YDLSKLRI--ALNGAEPIDETAVQTfvdaGARFkmpaecvFPAYGMAEATLAVSFAPLFTgltldvveadaleaenravp 376
Cdd:cd17637  111 VDLSSLRHvlGLDAPETIQRFEETT----GATF-------WSLYGQTETSGLVTLSPYRE-------------------- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 377 vpegdpRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGY 456
Cdd:cd17637  160 ------RPGS--------AGRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNGWHHTGDLGR 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 457 L-VDGQIVICGRR--KDVIIMGGRNLYPTDIERA--------ATSVEGV---RAGNAV-AVrldagsrrerfaVVLEskl 521
Cdd:cd17637  226 FdEDGYLWYAGRKpeKELIKPGGENVYPAEVEKVilehpaiaEVCVIGVpdpKWGEGIkAV------------CVLK--- 290
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 300790052 522 AGDAEAEKNLMKQVSARVrdAVDMRPYAVVVlpAGSLPKTPSGKVKR 568
Cdd:cd17637  291 PGATLTADELIEFVGSRI--ARYKKPRYVVF--VEALPKTADGSIDR 333
PRK09274 PRK09274
peptide synthase; Provisional
156-509 1.22e-12

peptide synthase; Provisional


Pssm-ID: 236443 [Multi-domain]  Cd Length: 552  Bit Score: 70.31  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 156 GFQLITELAAAEPLP-DVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMveRAEFDF---DVDvmvswLPTFh 231
Cdd:PRK09274 151 GTTLATLLRDGAAAPfPMADLAPDDMAAILFTSGSTGTPKGVVYTHGMFEAQIEAL--REDYGIepgEID-----LPTF- 222
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 232 dmgmvgfltvpmtfgvelvkitPVEFLSGPL-----IWPEL----------------ITKYHGTTTaapnFAYAIVGRRM 290
Cdd:PRK09274 223 ----------------------PLFALFGPAlgmtsVIPDMdptrpatvdpaklfaaIERYGVTNL----FGSPALLERL 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 291 ARVDEDDAYDLSKLRIALNGAEPIDETAVQTF---VDAGARfkmpaecVFPAYGMAEAtLAVSfaplftgltldVVEADA 367
Cdd:PRK09274 277 GRYGEANGIKLPSLRRVISAGAPVPIAVIERFramLPPDAE-------ILTPYGATEA-LPIS-----------SIESRE 337
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 368 LEAENRAVPvpegDPRRGTdgvrsfaLLGRPLDGLEAEIVD---------DAGKRVDEREVGEIRLRGEAVTPGYLtmDG 438
Cdd:PRK09274 338 ILFATRAAT----DNGAGI-------CVGRPVDGVEVRIIAisdapipewDDALRLATGEIGEIVVAGPMVTRSYY--NR 404
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052 439 PLATQ-----DEDG--WLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSR 509
Cdd:PRK09274 405 PEATRlakipDGQGdvWHRMGDLGYLdAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGVKRSALVGVGVPGAQR 483
PRK08276 PRK08276
long-chain-fatty-acid--CoA ligase; Validated
32-568 1.27e-12

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236215 [Multi-domain]  Cd Length: 502  Bit Score: 70.32  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  32 RTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmigS 111
Cdd:PRK08276  12 VTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDD---------S 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 112 DQDALGGPGGLAP--RPGSGAGPRNVTVLL--GEPFDqlapvleqkgiGFQLITELAAAEPlpDVVVTDEGDTALLQLTS 187
Cdd:PRK08276  83 GAKVLIVSAALADtaAELAAELPAGVPLLLvvAGPVP-----------GFRSYEEALAAQP--DTPIADETAGADMLYSS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 188 GSTADPKAVR--ITYGNLYSNVKAMVERAEFDFDVD---VMVSWLPTFHDMGMVGFLTVpMTFGVELV---KITPVEFLs 259
Cdd:PRK08276 150 GTTGRPKGIKrpLPGLDPDEAPGMMLALLGFGMYGGpdsVYLSPAPLYHTAPLRFGMSA-LALGGTVVvmeKFDAEEAL- 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 260 gpliwpELITKYHGTTTA-APnfayaIVGRRMARVDED--DAYDLSKLRIALNGAEPIDETAVQTFVD-AGArfkmpaeC 335
Cdd:PRK08276 228 ------ALIERYRVTHSQlVP-----TMFVRMLKLPEEvrARYDVSSLRVAIHAAAPCPVEVKRAMIDwWGP-------I 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 336 VFPAYGMAEATlavsfaplftGLTLdVVEADALEaenravpvpegdpRRGTdgvrsfalLGRPLDGlEAEIVDDAGKRVD 415
Cdd:PRK08276 290 IHEYYASSEGG----------GVTV-ITSEDWLA-------------HPGS--------VGKAVLG-EVRILDEDGNELP 336
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 416 EREVGEIRLRGEAVTPGYLtmDGPLAT---QDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSV 491
Cdd:PRK08276 337 PGEIGTVYFEMDGYPFEYH--NDPEKTaaaRNPHGWVTVGDVGYLdEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTH 414
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 492 EGVrAGNAVAVRLDAGSRRERFAVV--LESKLAGDAEAEKNLmkqVSARVRDAVDMRPYAVVVLPAgsLPKTPSGK-VKR 568
Cdd:PRK08276 415 PKV-ADVAVFGVPDEEMGERVKAVVqpADGADAGDALAAELI---AWLRGRLAHYKCPRSIDFEDE--LPRTPTGKlYKR 488
PRK12316 PRK12316
peptide synthase; Provisional
33-570 1.64e-12

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 71.14  E-value: 1.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDTVRVLGMIGSD 112
Cdd:PRK12316 2030 SYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALLLTQRH 2109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  113 -QDALGGPGGLAprpgsgagprnvtVLLGEPFDQLApvleqkgigfqlitELAAAEPLPDvvvTDEGDTALLQLTSGSTA 191
Cdd:PRK12316 2110 lLERLPLPAGVA-------------RLPLDRDAEWA--------------DYPDTAPAVQ---LAGENLAYVIYTSGSTG 2159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  192 DPKAVRITYGNLYSNVKAMVERAEFDfDVDVMVSWLPTFHDmGMVGFLTVPMTFGVELVkitpvefLSGPLIW-PELI-- 268
Cdd:PRK12316 2160 LPKGVAVSHGALVAHCQAAGERYELS-PADCELQFMSFSFD-GAHEQWFHPLLNGARVL-------IRDDELWdPEQLyd 2230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  269 -TKYHGTTTAAPNFAYAivgRRMARVDEDDAYDLsKLRIALNGAEPIDetavQTFVDAGARfKMPAECVFPAYGMAEATL 347
Cdd:PRK12316 2231 eMERHGVTILDFPPVYL---QQLAEHAERDGRPP-AVRVYCFGGEAVP----AASLRLAWE-ALRPVYLFNGYGPTEAVV 2301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  348 AVSfaplftgltldVVEADALEAENRAvpvpegdprrgtdgvrsFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGE 427
Cdd:PRK12316 2302 TPL-----------LWKCRPQDPCGAA-----------------YVPIGRALGNRRAYILDADLNLLAPGMAGELYLGGE 2353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  428 AVTPGYLTMDGPLATQ------DEDGWL--NTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRagN 498
Cdd:PRK12316 2354 GLARGYLNRPGLTAERfvpdpfSASGERlyRTGDLArYRADGVVEYLGRIDHQVKIRGFRIELGEIEARLQAHPAVR--E 2431
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300790052  499 AVAVRLDAGSRRERFAVVLESKLAGDAEAEknLMKQVSARVRDAvdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:PRK12316 2432 AVVVAQDGASGKQLVAYVVPDDAAEDLLAE--LRAWLAARLPAY--MVPAHWVVLER--LPLNPNGKLDRKA 2497
FCS cd05921
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...
8-459 2.57e-12

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.


Pssm-ID: 341245 [Multi-domain]  Cd Length: 561  Bit Score: 69.38  E-value: 2.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   8 LVATATKRGQQRGMVTGEPKEPVRR-TWAEVHEEARRIAGGLVAGGFERGTAVGVLAA--------------APVLIAPT 72
Cdd:cd05921    1 LAHWARQAPDRTWLAEREGNGGWRRvTYAEALRQVRAIAQGLLDLGLSAERPLLILSGnsiehalmalaamyAGVPAAPV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  73 VQAVWLAGGSVTMLH----QPTPRTDLAEWAEDTVRVLGMIGSDQDALGGPGGLAPrpgsgagprnvtvllGEPFDQLAP 148
Cdd:cd05921   81 SPAYSLMSQDLAKLKhlfeLLKPGLVFAQDAAPFARALAAIFPLGTPLVVSRNAVA---------------GRGAISFAE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 149 VLEQkgigfqliTELAAAEPLPDVVVTDegDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVE-RAEFDFDVDVMVSWL 227
Cdd:cd05921  146 LAAT--------PPTAAVDAAFAAVGPD--TVAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQtYPFFGEEPPVLVDWL 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 228 P---TF---HDMGMV----GFLTV----PMTFGVE-----LVKITPVEFLSGPLIWPELITKYHGTTTAAPNF------- 281
Cdd:cd05921  216 PwnhTFggnHNFNLVlyngGTLYIddgkPMPGGFEetlrnLREISPTVYFNVPAGWEMLVAALEKDEALRRRFfkrlklm 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 282 AYAivGRRMArvdeDDAYDlsklrialngaePIDETAVQTfvdAGARFKMPAecvfpAYGMAEAtlavsfAPLFTGLTLD 361
Cdd:cd05921  296 FYA--GAGLS----QDVWD------------RLQALAVAT---VGERIPMMA-----GLGATET------APTATFTHWP 343
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 362 VVEAdaleaenravpvpegdprrgtdgvrsfALLGRPLDGLEAEIVDDAGKRvderevgEIRLRGEAVTPGYLtmDGPLA 441
Cdd:cd05921  344 TERS---------------------------GLIGLPAPGTELKLVPSGGKY-------EVRVKGPNVTPGYW--RQPEL 387
                        490       500
                 ....*....|....*....|.
gi 300790052 442 TQ---DEDGWLNTGDLGYLVD 459
Cdd:cd05921  388 TAqafDEEGFYCLGDAAKLAD 408
MACS_AAE_MA_like cd05970
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...
266-570 3.37e-12

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.


Pssm-ID: 341274 [Multi-domain]  Cd Length: 537  Bit Score: 69.06  E-value: 3.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 266 ELITKYHGTTTAAPNFAYaivgRRMARVDEDDaYDLSKLRIALNGAEPIDETAVQTFVDAGARFKMPAecvfpaYGMAEA 345
Cdd:cd05970  270 EKLSKYGVTTFCAPPTIY----RFLIREDLSR-YDLSSLRYCTTAGEALNPEVFNTFKEKTGIKLMEG------FGQTET 338
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 346 TLAVSFAPLFtgltldvveadaleaenravpvpegDPRRGTdgvrsfalLGRPLDGLEAEIVDDAGKRVDEREVGEIRLR 425
Cdd:cd05970  339 TLTIATFPWM-------------------------EPKPGS--------MGKPAPGYEIDLIDREGRSCEAGEEGEIVIR 385
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 426 GEAVTP-----GYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATS----VEGVR 495
Cdd:cd05970  386 TSKGKPvglfgGYYKDAEKTAEVWHDGYYHTGDAAWMdEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQhpavLECAV 465
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300790052 496 AGNAVAVRldaGSRRERFAVvleskLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVVLPAGSLPKTPSGKVKRAA 570
Cdd:cd05970  466 TGVPDPIR---GQVVKATIV-----LAKGYEPSEELKKELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRRVE 532
PRK05857 PRK05857
fatty acid--CoA ligase;
395-572 4.05e-12

fatty acid--CoA ligase;


Pssm-ID: 180293 [Multi-domain]  Cd Length: 540  Bit Score: 68.88  E-value: 4.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAG------KRVDEREVGEIRLRGEAVTPGYltMDGPLATQD--EDGWLNTGDL-GYLVDGQIVIC 465
Cdd:PRK05857 344 VGRPYPGVDVYLAATDGigptapGAGPSASFGTLWIKSPANMLGY--WNNPERTAEvlIDGWVNTGDLlERREDGFFYIK 421
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 466 GRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLagDAEAEKNLMKQVSARVRDAVD- 544
Cdd:PRK05857 422 GRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAEL--DESAARALKHTIAARFRRESEp 499
                        170       180
                 ....*....|....*....|....*....
gi 300790052 545 -MRPYAVVVLpaGSLPKTPSGKVKRAATA 572
Cdd:PRK05857 500 mARPSTIVIV--TDIPRTQSGKVMRASLA 526
ACS-like cd17634
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...
15-566 4.57e-12

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341289 [Multi-domain]  Cd Length: 587  Bit Score: 68.76  E-value: 4.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  15 RGQQRGMVTGEPKEPVRRTW--AEVHEEARRIAGGLVAGGFERGTAVGVLAaaPVLiaPTVQAVWLAGGSVTMLHQP--- 89
Cdd:cd17634   66 NGDRTAIIYEGDDTSQSRTIsyRELHREVCRFAGTLLDLGVKKGDRVAIYM--PMI--PEAAVAMLACARIGAVHSVifg 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  90 --TPRTDLAEWAEDTVRVLgmIGSDqdalggpGGLapRPG---------------SGAGPRNVTVLLGEPfdqlAPVLEQ 152
Cdd:cd17634  142 gfAPEAVAGRIIDSSSRLL--ITAD-------GGV--RAGrsvplkknvddalnpNVTSVEHVIVLKRTG----SDIDWQ 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 153 KGIGFQLITELAAAEPLPDVVVTDEGDTALLQLTSGSTADPK-AVRITYGNLYSNVKAMveRAEFDFDVDVMVSWlptFH 231
Cdd:cd17634  207 EGRDLWWRDLIAKASPEHQPEAMNAEDPLFILYTSGTTGKPKgVLHTTGGYLVYAATTM--KYVFDYGPGDIYWC---TA 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 232 DMG-MVGFLTvpMTFGVELVKITPVEFLSGPlIWP------ELITKyHGTTT--AAPNfayAIVGRRMARVDEDDAYDLS 302
Cdd:cd17634  282 DVGwVTGHSY--LLYGPLACGATTLLYEGVP-NWPtparmwQVVDK-HGVNIlyTAPT---AIRALMAAGDDAIEGTDRS 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 303 KLRIALNGAEPIDETAVQTFVDAGARFKMPaecVFPAYGMAEATLAVsfAPLFTGltldvveADALEAENRAVPVPegdp 382
Cdd:cd17634  355 SLRILGSVGEPINPEAYEWYWKKIGKEKCP---VVDTWWQTETGGFM--ITPLPG-------AIELKAGSATRPVF---- 418
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 383 rrgtdgvrsfallgrpldGLEAEIVDDAGKRVDEREVGEIRLrGEAVTPGYLTMDGPLATQDE------DGWLNTGDLGY 456
Cdd:cd17634  419 ------------------GVQPAVVDNEGHPQPGGTEGNLVI-TDPWPGQTRTLFGDHERFEQtyfstfKGMYFSGDGAR 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 457 L-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLagdaEAEKNLMKQV 535
Cdd:cd17634  480 RdEDGYYWITGRSDDVINVAGHRLGTAEIESVLVAHPKVAEAAVVGIPHAIKGQAPYAYVVLNHGV----EPSPELYAEL 555
                        570       580       590
                 ....*....|....*....|....*....|...
gi 300790052 536 SARVRDavDMRPYAV--VVLPAGSLPKTPSGKV 566
Cdd:cd17634  556 RNWVRK--EIGPLATpdVVHWVDSLPKTRSGKI 586
PRK12492 PRK12492
long-chain-fatty-acid--CoA ligase; Provisional
153-568 5.23e-12

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 171539 [Multi-domain]  Cd Length: 562  Bit Score: 68.31  E-value: 5.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 153 KGIGFQLITELAAAEPLPDVVVTDEgDTALLQLTSGSTADPKAVRITYGNLYSN---VKAMVER------AEFDFDVDVM 223
Cdd:PRK12492 183 QAVPFKQALRQGRGLSLKPVPVGLD-DIAVLQYTGGTTGLAKGAMLTHGNLVANmlqVRACLSQlgpdgqPLMKEGQEVM 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 224 VSWLPTFHDMGMVGFLTVPMTFGVELVKITPVEFLSGpliWPELITKYHGTTTAAPNFAYaivgrrMARVDEDD--AYDL 301
Cdd:PRK12492 262 IAPLPLYHIYAFTANCMCMMVSGNHNVLITNPRDIPG---FIKELGKWRFSALLGLNTLF------VALMDHPGfkDLDF 332
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 302 SKLRIALNGAepideTAVqtfVDAGA-RFKMPAEC-VFPAYGMAEATLAVSFAPLftgltldvveadaleaENRAvpvpe 379
Cdd:PRK12492 333 SALKLTNSGG-----TAL---VKATAeRWEQLTGCtIVEGYGLTETSPVASTNPY----------------GELA----- 383
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 380 gdpRRGTDGVrsfallgrPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMdgPLATQ---DEDGWLNTGDLGY 456
Cdd:PRK12492 384 ---RLGTVGI--------PVPGTALKVIDDDGNELPLGERGELCIKGPQVMKGYWQQ--PEATAealDAEGWFKTGDIAV 450
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 457 L-VDGQIVICGRRKDVIIMGGRNLYPTDIER-----------AATSVEGVRAGNAV---AVRLDAGSRRERFAVVLESKL 521
Cdd:PRK12492 451 IdPDGFVRIVDRKKDLIIVSGFNVYPNEIEDvvmahpkvancAAIGVPDERSGEAVklfVVARDPGLSVEELKAYCKENF 530
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 300790052 522 AGdaeaeKNLMKQVSARvrdavdmrpyavvvlpaGSLPKTPSGKVKR 568
Cdd:PRK12492 531 TG-----YKVPKHIVLR-----------------DSLPMTPVGKILR 555
PRK08043 PRK08043
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
179-517 1.02e-11

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;


Pssm-ID: 181207 [Multi-domain]  Cd Length: 718  Bit Score: 67.81  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGM-VGFLTVPMTfGVELvkitpveF 257
Cdd:PRK08043 366 DAALILFTSGSEGHPKGVVHSHKSLLANVEQIKTIADFTPN-DRFMSALPLFHSFGLtVGLFTPLLT-GAEV-------F 436
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 258 L-SGPL---IWPELI-----TKYHGTTTAAPNFAyaivgrRMArvdedDAYDLSKLRIALNGAEPIDETAVQTFVDA-GA 327
Cdd:PRK08043 437 LyPSPLhyrIVPELVydrncTVLFGTSTFLGNYA------RFA-----NPYDFARLRYVVAGAEKLQESTKQLWQDKfGL 505
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 328 RfkmpaecVFPAYGMAEAtlavsfAPlftgltldVVeadaleaenrAVPVPEGdPRRGTdgvrsfalLGRPLDGLEAEIV 407
Cdd:PRK08043 506 R-------ILEGYGVTEC------AP--------VV----------SINVPMA-AKPGT--------VGRILPGMDARLL 545
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDAGKrvdeREVGEIRLRGEAVTPGYLTMDGP----------LATQDEDGWLNTGDLGYLVD-GQIVICGRRKDVIIMGG 476
Cdd:PRK08043 546 SVPGI----EQGGRLQLKGPNIMNGYLRVEKPgvlevptaenARGEMERGWYDTGDIVRFDEqGFVQIQGRAKRFAKIAG 621
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 300790052 477 RNLYPTDIERAATSVEGvRAGNAVAVRLDAgSRRErfAVVL 517
Cdd:PRK08043 622 EMVSLEMVEQLALGVSP-DKQHATAIKSDA-SKGE--ALVL 658
MACS_like_4 cd05969
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...
175-568 1.06e-11

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.


Pssm-ID: 341273 [Multi-domain]  Cd Length: 442  Bit Score: 67.14  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 175 TDEGDTALLQLTSGSTADPKAVRITYGNLYSnvKAMVERAEFDFDVDVMV------SWLptfhdMGMVGFLTVPMTFGVE 248
Cdd:cd05969   86 TDPEDPTLLHYTSGTTGTPKGVLHVHDAMIF--YYFTGKYVLDLHPDDIYwctadpGWV-----TGTVYGIWAPWLNGVT 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 249 LVkITPVEFlsGPLIWPELITKYHGTT--TAAPNFayaivgRRMARVDED--DAYDLSKLRIALNGAEPIDETAVQTFVD 324
Cdd:cd05969  159 NV-VYEGRF--DAESWYGIIERVKVTVwyTAPTAI------RMLMKEGDElaRKYDLSSLRFIHSVGEPLNPEAIRWGME 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 325 AgarFKMPaecVFPAYGMAE-ATLAVSFAPlftgltldvveadaleaenrAVPVPEGDprrgtdgvrsfalLGRPLDGLE 403
Cdd:cd05969  230 V---FGVP---IHDTWWQTEtGSIMIANYP--------------------CMPIKPGS-------------MGKPLPGVK 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 404 AEIVDDAGKRVDEREVGEIRLRGE--AVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLY 480
Cdd:cd05969  271 AAVVDENGNELPPGTKGILALKPGwpSMFRGIWNDEERYKNSFIDGWYLTGDLAYRdEDGYFWFVGRADDIIKTSGHRVG 350
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 481 PTDIERAATSVEGVrAGNAVAVRLDAgSRRERFA--VVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVvlpaGSL 558
Cdd:cd05969  351 PFEVESALMEHPAV-AEAGVIGKPDP-LRGEIIKafISLKEGFEPSDELKEEIINFVRQKLGAHVAPREIEFV----DNL 424
                        410
                 ....*....|
gi 300790052 559 PKTPSGKVKR 568
Cdd:cd05969  425 PKTRSGKIMR 434
PRK12467 PRK12467
peptide synthase; Provisional
30-570 1.17e-11

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 68.26  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   30 VRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDtvrvlgmi 109
Cdd:PRK12467 3119 QQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLDPEYPRERLAYMIED-------- 3190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  110 gsdqdalggpgglaprpgSGagprnVTVLLGEpfdqlAPVLEQKGI---GFQLITELAAAEPLPD---VVVTDEGDTALL 183
Cdd:PRK12467 3191 ------------------SG-----VKLLLTQ-----AHLLEQLPApagDTALTLDRLDLNGYSEnnpSTRVMGENLAYV 3242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  184 QLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLTVPMTfGVELVkITPVEFLSGPLI 263
Cdd:PRK12467 3243 IYTSGSTGKPKGVGVRHGALANHLCWIAEAYELDAN-DRVLLFMSFSFDGAQERFLWTLIC-GGCLV-VRDNDLWDPEEL 3319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  264 WPELitKYHGTTTAapNFAYAIVgrrMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFvdagaRFKMPAECVFPAYGMA 343
Cdd:PRK12467 3320 WQAI--HAHRISIA--CFPPAYL---QQFAEDAGGADCASLDIYVFGGEAVPPAAFEQV-----KRKLKPRGLTNGYGPT 3387
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  344 EATLAVsfaplftglTLDVVEADAlEAENRAVPVpegdprrgtdgvrsfallGRPLDGLEAEIVDDAGKRVDEREVGEIR 423
Cdd:PRK12467 3388 EAVVTV---------TLWKCGGDA-VCEAPYAPI------------------GRPVAGRSIYVLDGQLNPVPVGVAGELY 3439
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  424 LRGEAVTPGY-----LTMDGPLAT--QDEDGWL-NTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGV 494
Cdd:PRK12467 3440 IGGVGLARGYhqrpsLTAERFVADpfSGSGGRLyRTGDLArYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLLQHPSV 3519
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300790052  495 RagNAVAVRLDAGSRRERFAVVLESKLAGDAEAEknLMKQVSARVRDAvdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:PRK12467 3520 R--EAVVLARDGAGGKQLVAYVVPADPQGDWRET--LRDHLAASLPDY--MVPAQLLVLAA--MPLGPNGKVDRKA 3587
MACS_like_2 cd05973
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
396-568 1.99e-11

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341277 [Multi-domain]  Cd Length: 437  Bit Score: 66.39  E-value: 1.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVT----PGYLTMDGPLAtqdEDGWLNTGDLGYL-VDGQIVICGRRKD 470
Cdd:cd05973  262 GRAMPGWRVAVLDDDGDELGPGEPGRLAIDIANSPlmwfRGYQLPDTPAI---DGGYYLTGDTVEFdPDGSFSFIGRADD 338
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 471 VIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVrdAVDMRPYAV 550
Cdd:cd05973  339 VITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVLRGGHEGTPALADELQLHVKKRL--SAHAYPRTI 416
                        170
                 ....*....|....*...
gi 300790052 551 VVLPAgsLPKTPSGKVKR 568
Cdd:cd05973  417 HFVDE--LPKTPSGKIQR 432
PLN02736 PLN02736
long-chain acyl-CoA synthetase
117-485 4.47e-11

long-chain acyl-CoA synthetase


Pssm-ID: 178337 [Multi-domain]  Cd Length: 651  Bit Score: 65.51  E-value: 4.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 117 GGPGGLAPRPGSGAGPRNVTvllgepFDQLapvlEQKGIgfqlITELAAAEPLPDvvvtdegDTALLQLTSGSTADPKAV 196
Cdd:PLN02736 181 GGADEPLPSLPSGTGVEIVT------YSKL----LAQGR----SSPQPFRPPKPE-------DVATICYTSGTTGTPKGV 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 197 RITYGNLYSNVKAMVERAEFdFDVDVMVSWLPTFHDMGMVGFLtVPMTFGV--------------ELVKITPVEFLSGPL 262
Cdd:PLN02736 240 VLTHGNLIANVAGSSLSTKF-YPSDVHISYLPLAHIYERVNQI-VMLHYGVavgfyqgdnlklmdDLAALRPTIFCSVPR 317
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 263 IWPELITKYHGTTTAAPN-----FAYAIVGRRMARVDED------DAYDLSKL--------RIALNGAEPIDETaVQTF- 322
Cdd:PLN02736 318 LYNRIYDGITNAVKESGGlkerlFNAAYNAKKQALENGKnpspmwDRLVFNKIkaklggrvRFMSSGASPLSPD-VMEFl 396
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 323 -VDAGARfkmpaecVFPAYGMAEATLAVSfaplftglTLDvveadaleaenravpvpEGDprrgtdgvRSFALLGRPLDG 401
Cdd:PLN02736 397 rICFGGR-------VLEGYGMTETSCVIS--------GMD-----------------EGD--------NLSGHVGSPNPA 436
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 402 LEAEIVDdagkrVDEREV---------GEIRLRGEAVTPGYLTMDgpLATQ---DEDGWLNTGDLG-YLVDGQIVICGRR 468
Cdd:PLN02736 437 CEVKLVD-----VPEMNYtsedqpyprGEICVRGPIIFKGYYKDE--VQTReviDEDGWLHTGDIGlWLPGGRLKIIDRK 509
                        410
                 ....*....|....*...
gi 300790052 469 KDVIIMG-GRNLYPTDIE 485
Cdd:PLN02736 510 KNIFKLAqGEYIAPEKIE 527
PRK06178 PRK06178
acyl-CoA synthetase; Validated
139-576 4.95e-11

acyl-CoA synthetase; Validated


Pssm-ID: 235724 [Multi-domain]  Cd Length: 567  Bit Score: 65.45  E-value: 4.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 139 LGEPFDQLAPVLEQKGIgFQLITELAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLY----SNVKAMVERA 214
Cdd:PRK06178 171 LPLPDSLRAPRLAAAGA-IDLLPALRACTAPVPLPPPALDALAALNYTGGTTGMPKGCEHTQRDMVytaaAAYAVAVVGG 249
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 215 EfdfdVDVMVSWLPTF----HDMGMVgfltVPMTFGVELVKIT---PVEFLsgpliwpELITKYHGTTTAAP--NFAYAI 285
Cdd:PRK06178 250 E----DSVFLSFLPEFwiagENFGLL----FPLFSGATLVLLArwdAVAFM-------AAVERYRVTRTVMLvdNAVELM 314
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 286 VGRRMARvdeddaYDLSKLRialngaepidETAVQTFV-----DAGARFKMPAECVF--PAYGMAEATLAVSFAPLFTGL 358
Cdd:PRK06178 315 DHPRFAE------YDLSSLR----------QVRVVSFVkklnpDYRQRWRALTGSVLaeAAWGMTETHTCDTFTAGFQDD 378
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 359 TLDVveadaleaenRAVPVpegdprrgtdgvrsfaLLGRPLDGLEAEIVD-DAGKRVDEREVGEIRLRGEAVTPGYltMD 437
Cdd:PRK06178 379 DFDL----------LSQPV----------------FVGLPVPGTEFKICDfETGELLPLGAEGEIVVRTPSLLKGY--WN 430
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 438 GPLATQD--EDGWLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVrAGNAVAVRLDAGSRRERFA 514
Cdd:PRK06178 431 KPEATAEalRDGWLHTGDIGkIDEQGFLHYLGRRKEMLKVNGMSVFPSEVEALLGQHPAV-LGSAVVGRPDPDKGQVPVA 509
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300790052 515 -VVLESKLAGDAEAeknlmkqVSARVRDAvdMRPYAV---VVLPAgsLPKTPSGKVKRAATAQQFA 576
Cdd:PRK06178 510 fVQLKPGADLTAAA-------LQAWCREN--MAVYKVpeiRIVDA--LPMTATGKVRKQDLQALAE 564
PtmA cd17636
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ...
396-495 6.00e-11

long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341291 [Multi-domain]  Cd Length: 331  Bit Score: 63.86  E-value: 6.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLG-YLVDGQIVICGRRKDVIIM 474
Cdd:cd17636  166 GRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTRGGWHHTNDLGrREPDGSLSFVGPKTRMIKS 245
                         90       100
                 ....*....|....*....|.
gi 300790052 475 GGRNLYPTDIERAATSVEGVR 495
Cdd:cd17636  246 GAENIYPAEVERCLRQHPAVA 266
PRK12316 PRK12316
peptide synthase; Provisional
33-573 7.49e-11

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 65.75  E-value: 7.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDT-VRVLGMIGS 111
Cdd:PRK12316 4578 TYAELNRRANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEYPRERLAYMMEDSgAALLLTQSH 4657
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  112 DQDALGGPGGLAprpgsgagprnvtvllgepfdqlAPVLEQKGI--GFqlitelAAAEPLpdvVVTDEGDTALLQLTSGS 189
Cdd:PRK12316 4658 LLQRLPIPDGLA-----------------------SLALDRDEDweGF------PAHDPA---VRLHPDNLAYVIYTSGS 4705
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  190 TADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVswLPTFHDMGMVGFLTVPMTFGVELVkitpvefLSGPLIW-PE-- 266
Cdd:PRK12316 4706 TGRPKGVAVSHGSLVNHLHATGERYELTPDDRVLQ--FMSFSFDGSHEGLYHPLINGASVV-------IRDDSLWdPErl 4776
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  267 --LITKYHGTTTAAPNFAYaivgRRMARVDEDDAyDLSKLRIALNGAEpidetAVQTFVDAGARFKMPAECVFPAYGMAE 344
Cdd:PRK12316 4777 yaEIHEHRVTVLVFPPVYL----QQLAEHAERDG-EPPSLRVYCFGGE-----AVAQASYDLAWRALKPVYLFNGYGPTE 4846
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  345 ATLAVsfaplftgLTLDVveadaleaenravpvpegdpRRGTDGVRSFALLGRPLDGLEAEIVDDAGKRVDEREVGEIRL 424
Cdd:PRK12316 4847 TTVTV--------LLWKA--------------------RDGDACGAAYMPIGTPLGNRSGYVLDGQLNPLPVGVAGELYL 4898
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  425 RGEAVTPGYLTMDGPLATQ------DEDG--WLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVR 495
Cdd:PRK12316 4899 GGEGVARGYLERPALTAERfvpdpfGAPGgrLYRTGDLArYRADGVIDYLGRVDHQVKIRGFRIELGEIEARLREHPAVR 4978
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  496 AGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVD--MRPYAVVVLpaGSLPKTPSGKVKRAATAQ 573
Cdd:PRK12316 4979 EAVVIAQEGAVGKQLVGYVVPQDPALADADEAQAELRDELKAALRERLPeyMVPAHLVFL--ARMPLTPNGKLDRKALPQ 5056
CBAL cd05923
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...
3-568 8.16e-11

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.


Pssm-ID: 341247 [Multi-domain]  Cd Length: 493  Bit Score: 64.45  E-value: 8.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   3 RFVDTLVATATKRGQQRGMVTgEPKEPVRRTWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGS 82
Cdd:cd05923    1 QTVFEMLRRAASRAPDACAIA-DPARGLRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  83 VTMLH---QPTPRTDLAEWAEDTVRVLGMIGSDQDALGGPGG----LAPRPGSGagprnvtvllgepfdqlapvleqkgi 155
Cdd:cd05923   80 PALINprlKAAELAELIERGEMTAAVIAVDAQVMDAIFQSGVrvlaLSDLVGLG-------------------------- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 156 gfqlitELAAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDF-DVDVMVSWLPTFHDMG 234
Cdd:cd05923  134 ------EPESAGPLIEDPPREPEQPAFVFYTSGTTGLPKGAVIPQRAAESRVLFMSTQAGLRHgRHNVVLGLMPLYHVIG 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 235 MVGFLTVPMTFGVELVKIT---PVEFLSgpLIWPELITKYHGTTTAAPNFAYAIvgrrmarvdEDDAYDLSKLR-IALNG 310
Cdd:cd05923  208 FFAVLVAALALDGTYVVVEefdPADALK--LIEQERVTSLFATPTHLDALAAAA---------EFAGLKLSSLRhVTFAG 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 311 AepideTAVQTFVDAGARFKmPAECVfPAYGMAEAtLAVSFAPlftgltldvveadaleaenravpvpegDPRRGTDG-- 388
Cdd:cd05923  277 A-----TMPDAVLERVNQHL-PGEKV-NIYGTTEA-MNSLYMR---------------------------DARTGTEMrp 321
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 389 -----VRSFALLGRPL----DGLEAEIVDDAGkrvderevgeirlrGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-V 458
Cdd:cd05923  322 gffseVRIVRIGGSPDealaNGEEGELIVAAA--------------ADAAFTGYLNQPEATAKKLQDGWYRTGDVGYVdP 387
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 459 DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRagnAVAVrldAGSRRERFA-VVLESKLAGDAEAEKNLMKQVSA 537
Cdd:cd05923  388 SGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVT---EVVV---IGVADERWGqSVTACVVPREGTLSADELDQFCR 461
                        570       580       590
                 ....*....|....*....|....*....|.
gi 300790052 538 RVRDAVDMRPYAVVVLPAgsLPKTPSGKVKR 568
Cdd:cd05923  462 ASELADFKRPRRYFFLDE--LPKNAMNKVLR 490
PRK08180 PRK08180
feruloyl-CoA synthase; Reviewed
162-459 1.00e-10

feruloyl-CoA synthase; Reviewed


Pssm-ID: 236175 [Multi-domain]  Cd Length: 614  Bit Score: 64.51  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 162 ELAAAEPLPDVV----VTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMveRAEFDFDVD---VMVSWLP---TF- 230
Cdd:PRK08180 189 ALLATPPTAAVDaahaAVGPDTIAKFLFTSGSTGLPKAVINTHRMLCANQQML--AQTFPFLAEeppVLVDWLPwnhTFg 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 231 --HDMGMV----GFLTV----PMTFGVE-----LVKITPVEFLSGPLIWPELITkyhgtttaapnfayaivgrrMARVDE 295
Cdd:PRK08180 267 gnHNLGIVlyngGTLYIddgkPTPGGFDetlrnLREISPTVYFNVPKGWEMLVP--------------------ALERDA 326
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 296 DDAYDL-SKLRIALNGA--------EPIDETAVQTfvdAGARFKMPAecvfpAYGMAEAtlavsfAPLFTGLTldvvead 366
Cdd:PRK08180 327 ALRRRFfSRLKLLFYAGaalsqdvwDRLDRVAEAT---CGERIRMMT-----GLGMTET------APSATFTT------- 385
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 367 alEAENRAvpvpegdprrgtdgvrsfALLGRPLDGLEAEIVDDAGKRvderevgEIRLRGEAVTPGYLtmDGPLATQ--- 443
Cdd:PRK08180 386 --GPLSRA------------------GNIGLPAPGCEVKLVPVGGKL-------EVRVKGPNVTPGYW--RAPELTAeaf 436
                        330
                 ....*....|....*.
gi 300790052 444 DEDGWLNTGDLGYLVD 459
Cdd:PRK08180 437 DEEGYYRSGDAVRFVD 452
A_NRPS_GliP_like cd17653
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...
179-573 1.27e-10

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341308 [Multi-domain]  Cd Length: 433  Bit Score: 63.87  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYSNVKAMVER------------AEFDFDVDVmvswlptfhdmGMVgFLTvpMTFG 246
Cdd:cd17653  106 DLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPARldvgpgsrvaqvLSIAFDACI-----------GEI-FST--LCNG 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 247 VELVKITPveflSGPliWPELITKYHgTTTAAPNFayaivgrrMARVDEDDaydLSKLRIALNGAEPIDetavQTFVDAG 326
Cdd:cd17653  172 GTLVLADP----SDP--FAHVARTVD-ALMSTPSI--------LSTLSPQD---FPNLKTIFLGGEAVP----PSLLDRW 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 327 ArfkmPAECVFPAYGMAEATLAVSFAplftgltldvveadALEAENRAVpvpegdprrgtdgvrsfalLGRPLDGLEAEI 406
Cdd:cd17653  230 S----PGRRLYNAYGPTECTISSTMT--------------ELLPGQPVT-------------------IGKPIPNSTCYI 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 407 VDDAGKRVDEREVGEIRLRGEAVTPGYL-----TMDGPLATQDEDGWL--NTGDLGYLV-DGQIVICGRRKDVI-IMGGR 477
Cdd:cd17653  273 LDADLQPVPEGVVGEICISGVQVARGYLgnpalTASKFVPDPFWPGSRmyRTGDYGRWTeDGGLEFLGREDNQVkVRGFR 352
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 478 -NLYpTDIERAATSVEGVRAGNAVAV--RLDAgsrrerFAVVLESKLAGDAEAEKNLMKQVsarvrdavdMRPYAVVVLP 554
Cdd:cd17653  353 iNLE-EIEEVVLQSQPEVTQAAAIVVngRLVA------FVTPETVDVDGLRSELAKHLPSY---------AVPDRIIALD 416
                        410
                 ....*....|....*....
gi 300790052 555 agSLPKTPSGKVKRAATAQ 573
Cdd:cd17653  417 --SFPLTANGKVDRKALRE 433
PaaK COG1541
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ...
404-568 2.59e-10

Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];


Pssm-ID: 441150 [Multi-domain]  Cd Length: 423  Bit Score: 62.47  E-value: 2.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 404 AEIVD-DAGKRVDEREVGEIrlrgeAVTPgyLTMDG-PLatqdedgwL--NTGDLGYLVDGQ---------IV-ICGRRK 469
Cdd:COG1541  263 VEIIDpETGEPVPEGEEGEL-----VVTT--LTKEAmPL--------IryRTGDLTRLLPEPcpcgrthprIGrILGRAD 327
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 470 DVIIMGGRNLYPTDIERAATSVEGVrAGNAVAVrLDAGSRRERFAVVLEskLAGDAEAEKnLMKQVSARVRDAVDMRPyA 549
Cdd:COG1541  328 DMLIIRGVNVFPSQIEEVLLRIPEV-GPEYQIV-VDREGGLDELTVRVE--LAPGASLEA-LAEAIAAALKAVLGLRA-E 401
                        170
                 ....*....|....*....
gi 300790052 550 VVVLPAGSLPKTPsGKVKR 568
Cdd:COG1541  402 VELVEPGSLPRSE-GKAKR 419
PRK09029 PRK09029
O-succinylbenzoic acid--CoA ligase; Provisional
142-487 4.87e-10

O-succinylbenzoic acid--CoA ligase; Provisional


Pssm-ID: 236363 [Multi-domain]  Cd Length: 458  Bit Score: 61.81  E-value: 4.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 142 PFDQLAPVLEQKGIGFQLITELAAAEPLPDVVVTDEGDT-----------ALLQLTSGSTADPKAVRITYGNLYSNVKAM 210
Cdd:PRK09029  88 PQPLLEELLPSLTLDFALVLEGENTFSALTSLHLQLVEGahavawqpqrlATMTLTSGSTGLPKAAVHTAQAHLASAEGV 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 211 VEraEFDFDVDVmvSWL---PTFHDMGMvGFLTVPMTFGVELVKITPVEFLSGpliwpelitkYHGTTTAApnfayaIVG 287
Cdd:PRK09029 168 LS--LMPFTAQD--SWLlslPLFHVSGQ-GIVWRWLYAGATLVVRDKQPLEQA----------LAGCTHAS------LVP 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 288 RRMARVDEDDAYDLSKLRIALNGAEPIDETAVQtfvdagARfKMPAECvFPAYGMAEAtlavsfaplftGLTLDVVEADa 367
Cdd:PRK09029 227 TQLWRLLDNRSEPLSLKAVLLGGAAIPVELTEQ------AE-QQGIRC-WCGYGLTEM-----------ASTVCAKRAD- 286
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 368 leaenravpvpegdprrGTDGVrsfallGRPLDGLEAEIVDDagkrvderevgEIRLRGEAVTPGYLtMDG---PLAtqD 444
Cdd:PRK09029 287 -----------------GLAGV------GSPLPGREVKLVDG-----------EIWLRGASLALGYW-RQGqlvPLV--N 329
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 300790052 445 EDGWLNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIERA 487
Cdd:PRK09029 330 DEGWFATRDRGEWQNGELTILGRLDNLFFSGGEGIQPEEIERV 372
PrpE cd05967
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...
15-577 7.82e-10

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.


Pssm-ID: 341271 [Multi-domain]  Cd Length: 617  Bit Score: 61.56  E-value: 7.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  15 RGQQRGMVTGEPKEPVRR--TWAEVHEEARRIAGGLVAGGFERG------------TAVGVLAAAPVliaPTVQAVWLAG 80
Cdd:cd05967   64 RGDQIALIYDSPVTGTERtyTYAELLDEVSRLAGVLRKLGVVKGdrviiympmipeAAIAMLACARI---GAIHSVVFGG 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  81 GSVTMLHQptpRTDLAEwaedTVRVLGmigsdqdALGG--PGGLAP-RP-------GSGAGPRNVTVLlgePFDQLAPVL 150
Cdd:cd05967  141 FAAKELAS---RIDDAK----PKLIVT-------ASCGiePGKVVPyKPlldkaleLSGHKPHHVLVL---NRPQVPADL 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 151 EQKGIGFQLITELAAAEPLPDVVVtDEGDTALLQLTSGSTADPKAV-RITYGNLysnvkamveraefdfdvdVMVSW-LP 228
Cdd:cd05967  204 TKPGRDLDWSELLAKAEPVDCVPV-AATDPLYILYTSGTTGKPKGVvRDNGGHA------------------VALNWsMR 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 229 TFHDM--GMVGFLTVPM---------TFGVELVKITPVEFLSGPLIWPE------LITKyHGTTT--AAPNfayAIvgRR 289
Cdd:cd05967  265 NIYGIkpGDVWWAASDVgwvvghsyiVYGPLLHGATTVLYEGKPVGTPDpgafwrVIEK-YQVNAlfTAPT---AI--RA 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 290 MARVDEDDA----YDLSKLRIALNGAEPIDetaVQTFVDAGARFKMPaecVFPAYGMAEATLAVSFAPLftGLTLdvvea 365
Cdd:cd05967  339 IRKEDPDGKyikkYDLSSLRTLFLAGERLD---PPTLEWAENTLGVP---VIDHWWQTETGWPITANPV--GLEP----- 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 366 daleaenraVPVPEGDPrrgtdgvrsfallGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGeAVTPGYLTMdgpLATQDE 445
Cdd:cd05967  406 ---------LPIKAGSP-------------GKPVPGYQVQVLDEDGEPVGPNELGNIVIKL-PLPPGCLLT---LWKNDE 459
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 446 ----------DGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFA 514
Cdd:cd05967  460 rfkklylskfPGYYDTGDAGYKdEDGYLFIMGRTDDVINVAGHRLSTGEMEESVLSHPAVAECAVVGVRDELKGQVPLGL 539
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300790052 515 VVLEsklAGDAEAEKNLMKQVSARVRDAVD--MRPYAVVVLpaGSLPKTPSGKVKRaATAQQFAD 577
Cdd:cd05967  540 VVLK---EGVKITAEELEKELVALVREQIGpvAAFRLVIFV--KRLPKTRSGKILR-RTLRKIAD 598
PRK06164 PRK06164
acyl-CoA synthetase; Validated
418-539 1.37e-09

acyl-CoA synthetase; Validated


Pssm-ID: 235722 [Multi-domain]  Cd Length: 540  Bit Score: 60.91  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 418 EVGEIRLRGEAVTPGYLtmDGPLATQD---EDGWLNTGDLGYLV-DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEG 493
Cdd:PRK06164 376 ESGEIEIRAPSLMRGYL--DNPDATARaltDDGYFRTGDLGYTRgDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPG 453
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 300790052 494 VRAGNAVAVRLDAGSRRERFaVVLESKLAGDAEAEKNLMKQ------VSARV 539
Cdd:PRK06164 454 VAAAQVVGATRDGKTVPVAF-VIPTDGASPDEAGLMAACREalagfkVPARV 504
A_NRPS_ApnA-like cd17644
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ...
172-570 1.95e-09

similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341299 [Multi-domain]  Cd Length: 465  Bit Score: 60.14  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVER------------AEFDFDV---DVMVSWLPtfhdmgmv 236
Cdd:cd17644  100 VLLTQPENLAYVIYTSGSTGKPKGVMIEHQSLVNLSHGLIKEygitssdrvlqfASIAFDVaaeEIYVTLLS-------- 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 237 gfltvpmtfGVELVKITPVEFLSGPLIWP----ELITKYHGTTTAAPNFAYAIVgrrmarvdEDDAYDLSKLRIALNGAE 312
Cdd:cd17644  172 ---------GATLVLRPEEMRSSLEDFVQyiqqWQLTVLSLPPAYWHLLVLELL--------LSTIDLPSSLRLVIVGGE 234
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 313 PIDETAVQTFVDAGARFkmpAECvFPAYGMAEATLAVSFAplftgltldvveadaleaenravpvpegDPRRGTDGVRSF 392
Cdd:cd17644  235 AVQPELVRQWQKNVGNF---IQL-INVYGPTEATIAATVC----------------------------RLTQLTERNITS 282
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 393 ALLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMD---------GPLATQDEDGWLNTGDLG-YLVDGQI 462
Cdd:cd17644  283 VPIGRPIANTQVYILDENLQPVPVGVPGELHIGGVGLARGYLNRPeltaekfisHPFNSSESERLYKTGDLArYLPDGNI 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 463 VICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAgNAVAVRLD-AGSRRERFAVVLESKLAGDAEAEKNLMKQvsarvRD 541
Cdd:cd17644  363 EYLGRIDNQVKIRGFRIELGEIEAVLSQHNDVKT-AVVIVREDqPGNKRLVAYIVPHYEESPSTVELRQFLKA-----KL 436
                        410       420
                 ....*....|....*....|....*....
gi 300790052 542 AVDMRPYAVVVLPagSLPKTPSGKVKRAA 570
Cdd:cd17644  437 PDYMIPSAFVVLE--ELPLTPNGKIDRRA 463
A_NRPS_SidN3_like cd05918
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...
172-577 2.94e-09

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341242 [Multi-domain]  Cd Length: 481  Bit Score: 59.48  E-value: 2.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFD------------FDVDVMVSWLpTFHDMGMV--- 236
Cdd:cd05918  100 VLTSSPSDAAYVIFTSGSTGKPKGVVIEHRALSTSALAHGRALGLTsesrvlqfasytFDVSILEIFT-TLAAGGCLcip 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 237 ----------GFLTvpmTFGVELVKITPveflsgpliwpelitkyhgtttaapnfayaivgrRMARVDEDDayDLSKLRI 306
Cdd:cd05918  179 seedrlndlaGFIN---RLRVTWAFLTP----------------------------------SVARLLDPE--DVPSLRT 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 307 ALNGAEPIDETAVQTFVDaGARfkmpaecVFPAYGMAEATLAVSFAPlftgltldvveadaleaenravPVPEGDPRrgt 386
Cdd:cd05918  220 LVLGGEALTQSDVDTWAD-RVR-------LINAYGPAECTIAATVSP----------------------VVPSTDPR--- 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 387 dgvrsfaLLGRPLDGLeAEIVD--DAGKRVDEREVGEIRLRGEAVTPGYL---------TMDGPLATQDEDGWLN----- 450
Cdd:cd05918  267 -------NIGRPLGAT-CWVVDpdNHDRLVPIGAVGELLIEGPILARGYLndpektaaaFIEDPAWLKQEGSGRGrrlyr 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 451 TGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERA-ATSVEGVRAGNAVAVRLDAGSRRERFAVVL----------- 517
Cdd:cd05918  339 TGDLVrYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHlRQSLPGAKEVVVEVVKPKDGSSSPQLVAFVvldgsssgsgd 418
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300790052 518 -ESKLAGDAEAEKNLMKQVSARVRDAV--DMRPYAVVVLPagSLPKTPSGKVKRAATAQQFAD 577
Cdd:cd05918  419 gDSLFLEPSDEFRALVAELRSKLRQRLpsYMVPSVFLPLS--HLPLTASGKIDRRALRELAES 479
A_NRPS_ACVS-like cd17648
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ...
172-566 6.18e-09

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.


Pssm-ID: 341303 [Multi-domain]  Cd Length: 453  Bit Score: 58.57  E-value: 6.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 172 VVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVER----AEFDFDVDVMVSWLPTFHdmgmVGFLTVPMTFGV 247
Cdd:cd17648   88 VVITNSTDLAYAIYTSGTTGKPKGVLVEHGSVVNLRTSLSERyfgrDNGDEAVLFFSNYVFDFF----VEQMTLALLNGQ 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 248 ELVkITPVEFLSGPLIWPELI-----TKYHGTTTAAPNFAYAIVG--RRMARVDED-DAYDLSKLRialngaepidetav 319
Cdd:cd17648  164 KLV-VPPDEMRFDPDRFYAYInrekvTYLSGTPSVLQQYDLARLPhlKRVDAAGEEfTAPVFEKLR-------------- 228
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 320 qtfvdagARFKMPaecVFPAYGMAEATLAvsfaplftgltldvveadaleaeNRAVPVPEGDPRRGTdgvrsfalLGRPL 399
Cdd:cd17648  229 -------SRFAGL---IINAYGPTETTVT-----------------------NHKRFFPGDQRFDKS--------LGRPV 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 400 DGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMD---------GPLATQDE--DG----WLNTGDLG-YLVDGQIV 463
Cdd:cd17648  268 RNTKCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNRPeltaerflpNPFQTEQEraRGrnarLYKTGDLVrWLPSGELE 347
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 464 ICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGnAVAVRLDAGSRRERFAVVLESKLAGDAEA--EKNLMKQVSARVRD 541
Cdd:cd17648  348 YLGRNDFQVKIRGQRIEPGEVEAALASYPGVREC-AVVAKEDASQAQSRIQKYLVGYYLPEPGHvpESDLLSFLRAKLPR 426
                        410       420
                 ....*....|....*....|....*
gi 300790052 542 AvdMRPYAVVVLPagSLPKTPSGKV 566
Cdd:cd17648  427 Y--MVPARLVRLE--GIPVTINGKL 447
PRK07008 PRK07008
long-chain-fatty-acid--CoA ligase; Validated
396-577 7.70e-09

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235908 [Multi-domain]  Cd Length: 539  Bit Score: 58.18  E-value: 7.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRV--DEREVGEIRLRGEAVTPGYLTMDG-PLAtqdeDGWLNTGDLGYL-VDGQIVICGRRKDV 471
Cdd:PRK07008 359 GRVIYGVDMKIVGDDGRELpwDGKAFGDLQVRGPWVIDRYFRGDAsPLV----DGWFPTGDVATIdADGFMQITDRSKDV 434
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 472 IIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVlesKLAGDAEAEKNLMKQVSARVrdAVDMRPYAVV 551
Cdd:PRK07008 435 IKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERPLLVVV---KRPGAEVTREELLAFYEGKV--AKWWIPDDVV 509
                        170       180
                 ....*....|....*....|....*.
gi 300790052 552 VLPAgsLPKTPSGKVKRAATAQQFAD 577
Cdd:PRK07008 510 FVDA--IPHTATGKLQKLKLREQFRD 533
PTZ00216 PTZ00216
acyl-CoA synthetase; Provisional
175-469 9.74e-09

acyl-CoA synthetase; Provisional


Pssm-ID: 240316 [Multi-domain]  Cd Length: 700  Bit Score: 58.06  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 175 TDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVER-----AEFDFDvDVMVSWLPTFHDM------------GMVG 237
Cdd:PTZ00216 261 ENNDDLALIMYTSGTTGDPKGVMHTHGSLTAGILALEDRlndliGPPEED-ETYCSYLPLAHIMefgvtniflargALIG 339
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 238 FLTvPMTF--------GvELVKITPVEFLSGPLIWpELITKYHGTTTAAPN------FAYAIVGRRMARVDEDDA----- 298
Cdd:PTZ00216 340 FGS-PRTLtdtfarphG-DLTEFRPVFLIGVPRIF-DTIKKAVEAKLPPVGslkrrvFDHAYQSRLRALKEGKDTpywne 416
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 299 --YDL------SKLRIALNGAEPIDEtAVQTFVDAgaRFKMpaecVFPAYGMAEaTLAVSFAPLFTGLTLDVVeadalea 370
Cdd:PTZ00216 417 kvFSApravlgGRVRAMLSGGGPLSA-ATQEFVNV--VFGM----VIQGWGLTE-TVCCGGIQRTGDLEPNAV------- 481
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 371 enravpvpegdprrgtdgvrsfallGRPLDGLEAEIVD-DAGKRVDEREV-GEIRLRGEAVTPGYLTMdgPLATQ---DE 445
Cdd:PTZ00216 482 -------------------------GQLLKGVEMKLLDtEEYKHTDTPEPrGEILLRGPFLFKGYYKQ--EELTRevlDE 534
                        330       340
                 ....*....|....*....|....*
gi 300790052 446 DGWLNTGDLGYL-VDGQIVICGRRK 469
Cdd:PTZ00216 535 DGWFHTGDVGSIaANGTLRIIGRVK 559
PRK13391 PRK13391
acyl-CoA synthetase; Provisional
164-485 1.07e-08

acyl-CoA synthetase; Provisional


Pssm-ID: 184022 [Multi-domain]  Cd Length: 511  Bit Score: 57.78  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 164 AAAEPLPDVVVTDEGDTALLQLTSGSTADPKAVritYGNLYSnvkamveraefdfdvdvmvswLPTFHDMGMVGFLTVPM 243
Cdd:PRK13391 140 EAVAGLPATPIADESLGTDMLYSSGTTGRPKGI---KRPLPE---------------------QPPDTPLPLTAFLQRLW 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 244 TFGVELVKITPVE-FLSGPLIWPELITKYHGTTTAAPNF----AYAIVGR--------------RMARVDED--DAYDLS 302
Cdd:PRK13391 196 GFRSDMVYLSPAPlYHSAPQRAVMLVIRLGGTVIVMEHFdaeqYLALIEEygvthtqlvptmfsRMLKLPEEvrDKYDLS 275
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 303 KLRIALNGAEPIDETAVQTFVDagarFKMPAecVFPAYGMAEATLavsfaplFTGLTldvvEADALEaenravpvpegdp 382
Cdd:PRK13391 276 SLEVAIHAAAPCPPQVKEQMID----WWGPI--IHEYYAATEGLG-------FTACD----SEEWLA------------- 325
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 383 RRGTdgvrsfalLGRPLDGlEAEIVDDAGKRVDEREVGEIRLRGEavTP-GYLTMDGPLA-TQDEDG-WLNTGDLGYL-V 458
Cdd:PRK13391 326 HPGT--------VGRAMFG-DLHILDDDGAELPPGEPGTIWFEGG--RPfEYLNDPAKTAeARHPDGtWSTVGDIGYVdE 394
                        330       340
                 ....*....|....*....|....*..
gi 300790052 459 DGQIVICGRRKDVIIMGGRNLYPTDIE 485
Cdd:PRK13391 395 DGYLYLTDRAAFMIISGGVNIYPQEAE 421
PRK13390 PRK13390
acyl-CoA synthetase; Provisional
163-566 3.87e-08

acyl-CoA synthetase; Provisional


Pssm-ID: 139538 [Multi-domain]  Cd Length: 501  Bit Score: 56.17  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 163 LAAAEPlpdvVVTDEGDTALLQLTSGSTADPKAVRitygnlysnvKAMVERaEFDFDVDVMVSWLPTFHDMGM--VGFLT 240
Cdd:PRK13390 137 LAGAGP----RLTEQPCGAVMLYSSGTTGFPKGIQ----------PDLPGR-DVDAPGDPIVAIARAFYDISEsdIYYSS 201
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 241 VPMtfgvelvkitpveFLSGPLIWPELITKYHGTTTAAPNF-AYAIVGR-----------------RMARVDED--DAYD 300
Cdd:PRK13390 202 API-------------YHAAPLRWCSMVHALGGTVVLAKRFdAQATLGHveryritvtqmvptmfvRLLKLDADvrTRYD 268
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 301 LSKLRIALNGAEPIDETAVQTFVDagarfkMPAECVFPAYGMAEATlavsfaplftGLTLdvveadaleaenraVPVPEG 380
Cdd:PRK13390 269 VSSLRAVIHAAAPCPVDVKHAMID------WLGPIVYEYYSSTEAH----------GMTF--------------IDSPDW 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 381 DPRRGTdgvrsfalLGRPLDGlEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDG---WLNTGDLGYL 457
Cdd:PRK13390 319 LAHPGS--------VGRSVLG-DLHICDDDGNELPAGRIGTVYFERDRLPFRYLNDPEKTAAAQHPAhpfWTTVGDLGSV 389
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 458 -VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVS 536
Cdd:PRK13390 390 dEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDPEMGEQVKAVIQLVEGIRGSDELARELIDYTR 469
                        410       420       430
                 ....*....|....*....|....*....|
gi 300790052 537 ARVRDAVDMRPYAVVvlpaGSLPKTPSGKV 566
Cdd:PRK13390 470 SRIAHYKAPRSVEFV----DELPRTPTGKL 495
PRK07824 PRK07824
o-succinylbenzoate--CoA ligase;
396-578 1.06e-07

o-succinylbenzoate--CoA ligase;


Pssm-ID: 236108 [Multi-domain]  Cd Length: 358  Bit Score: 54.28  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDdagkrvderevGEIRLRGEAVTPGY--LTMDGPLAtqdEDGWLNTGDLGYLVDGQIVICGRRKDVII 473
Cdd:PRK07824 195 GVPLDGVRVRVED-----------GRIALGGPTLAKGYrnPVDPDPFA---EPGWFRTDDLGALDDGVLTVLGRADDAIS 260
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 474 MGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLEsklAGDAEAEKNLMKQVSARVRDAVDMRPYAVVvl 553
Cdd:PRK07824 261 TGGLTVLPQVVEAALATHPAVADCAVFGLPDDRLGQRVVAAVVGD---GGPAPTLEALRAHVARTLDRTAAPRELHVV-- 335
                        170       180
                 ....*....|....*....|....*
gi 300790052 554 paGSLPKTPSGKVKRAATAQQFADR 578
Cdd:PRK07824 336 --DELPRRGIGKVDRRALVRRFAGE 358
PRK13388 PRK13388
acyl-CoA synthetase; Provisional
158-502 1.19e-07

acyl-CoA synthetase; Provisional


Pssm-ID: 237374 [Multi-domain]  Cd Length: 540  Bit Score: 54.65  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 158 QLITELAAAEPLPDVvvtDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVG 237
Cdd:PRK13388 133 ELVAAAGALTPHREV---DAMDPFMLIFTSGTTGAPKAVRCSHGRLAFAGRALTERFGLTRD-DVCYVSMPLFHSNAVMA 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 238 FLTVPMTFGVELV---KITPVEFLSGpliwpelITKYHGTTtaapnFAYaiVGRRMA-------RVDEDDaydlSKLRIA 307
Cdd:PRK13388 209 GWAPAVASGAAVAlpaKFSASGFLDD-------VRRYGATY-----FNY--VGKPLAyilatpeRPDDAD----NPLRVA 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 308 L-NGAEPIDETA-VQTFvdaGARfkmpaecVFPAYGMAEATLAVSFAPLFtgltldvveadaleaenravpvPEGDPRRG 385
Cdd:PRK13388 271 FgNEASPRDIAEfSRRF---GCQ-------VEDGYGSSEGAVIVVREPGT----------------------PPGSIGRG 318
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 386 TDGVR-------------SFALLGRPLDGLEA--EIVDDAGKRVDErevgeirlrgeavtpGYLTMDGPLATQDEDGWLN 450
Cdd:PRK13388 319 APGVAiynpetltecavaRFDAHGALLNADEAigELVNTAGAGFFE---------------GYYNNPEATAERMRHGMYW 383
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 300790052 451 TGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVragNAVAV 502
Cdd:PRK13388 384 SGDLAYRdADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAI---NRVAV 433
PRK05620 PRK05620
long-chain fatty-acid--CoA ligase;
396-494 1.52e-07

long-chain fatty-acid--CoA ligase;


Pssm-ID: 180167 [Multi-domain]  Cd Length: 576  Bit Score: 54.40  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAgkRVDE---REVGEIRLRGEAVTPGYL-----TMDGPLATQD------------EDGWLNTGDLG 455
Cdd:PRK05620 361 GRFPASLEYRIVNDG--QVMEstdRNEGEIQVRGNWVTASYYhspteEGGGAASTFRgedvedandrftADGWLRTGDVG 438
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 300790052 456 YLV-DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGV 494
Cdd:PRK05620 439 SVTrDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEV 478
A_NRPS_acs4 cd17654
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ...
186-496 2.98e-07

acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341309 [Multi-domain]  Cd Length: 449  Bit Score: 53.24  E-value: 2.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 186 TSGSTADPKAVRITYGNLYSNVKAMveRAEFDFDVDVMVswlptfhdmgmvgFLTVPMTFGVELVK------------IT 253
Cdd:cd17654  126 TSGTTGTPKIVAVPHKCILPNIQHF--RSLFNITSEDIL-------------FLTSPLTFDPSVVEiflslssgatllIV 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 254 PVEFLSGPLIWPELITKYHGTTTAapnFAYAIVGRRMARVDEDDAY--DLSKLRIALNGAEPIdetaVQTFVDAGARFKM 331
Cdd:cd17654  191 PTSVKVLPSKLADILFKRHRITVL---QATPTLFRRFGSQSIKSTVlsATSSLRVLALGGEPF----PSLVILSSWRGKG 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 332 PAECVFPAYGMAEATlavSFAplftgLTLDVVEADAleaenravPVPegdprrgtdgvrsfalLGRPLDGLEAEIVDDAG 411
Cdd:cd17654  264 NRTRIFNIYGITEVS---CWA-----LAYKVPEEDS--------PVQ----------------LGSPLLGTVIEVRDQNG 311
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 412 KRVD-EREVGEIRLRGeaVTPGYltMDGPLATqdedgWLNTGDLGYLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATS 490
Cdd:cd17654  312 SEGTgQVFLGGLNRVC--ILDDE--VTVPKGT-----MRATGDFVTVKDGELFFLGRKDSQIKRRGKRINLDLIQQVIES 382

                 ....*.
gi 300790052 491 VEGVRA 496
Cdd:cd17654  383 CLGVES 388
PRK06060 PRK06060
p-hydroxybenzoic acid--AMP ligase FadD22;
158-574 4.17e-07

p-hydroxybenzoic acid--AMP ligase FadD22;


Pssm-ID: 180374 [Multi-domain]  Cd Length: 705  Bit Score: 53.11  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 158 QLITELAAAEPLPDVVVTdeGDT-ALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVSWLPTFHDMGMV 236
Cdd:PRK06060 126 ELMSEAARVAPGGYEPMG--GDAlAYATYTSGTTGPPKAAIHRHADPLTFVDAMCRKALRLTPEDTGLCSARMYFAYGLG 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 237 GFLTVPMTFGVELVkITPVEFlsGPLIWPELITKYHGTTT-AAPNFayaivgrrMARVdeddaydlsklrialngaepID 315
Cdd:PRK06060 204 NSVWFPLATGGSAV-INSAPV--TPEAAAILSARFGPSVLyGVPNF--------FARV--------------------ID 252
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 316 ETAVQTFvdagarfkMPAECVFPAYGMAEATLAVSFAPLFTGL-TLDVVEADalEAENRAVPVPEGDPRRGTdgvrsfal 394
Cdd:PRK06060 253 SCSPDSF--------RSLRCVVSAGEALELGLAERLMEFFGGIpILDGIGST--EVGQTFVSNRVDEWRLGT-------- 314
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDGPLATqdEDGWLNTGDLGYLV-DGQIVICGRRKDVII 473
Cdd:PRK06060 315 LGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSPVA--NEGWLDTRDRVCIDsDGWVTYRCRADDTEV 392
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 474 MGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARVRDAVDMRPYAVVvl 553
Cdd:PRK06060 393 IGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATIDGSVMRDLHRGLLNRLSAFKVPHRFAVV-- 470
                        410       420
                 ....*....|....*....|.
gi 300790052 554 paGSLPKTPSGKVKRAATAQQ 574
Cdd:PRK06060 471 --DRLPRTPNGKLVRGALRKQ 489
PRK07867 PRK07867
acyl-CoA synthetase; Validated
162-575 6.14e-07

acyl-CoA synthetase; Validated


Pssm-ID: 236120 [Multi-domain]  Cd Length: 529  Bit Score: 52.38  E-value: 6.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 162 ELAA-AEPLPDVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLT 240
Cdd:PRK07867 135 ELAAhRDAEPPFRVADPDDLFMLIFTSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPD-DVCYVSMPLFHSNAVMAGWA 213
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 241 VPMTFGVELV---KITPVEFLSGpliwpelITKYHGTttaapnfaYA-IVGRRMARV-----DEDDAYdlSKLRIAL-NG 310
Cdd:PRK07867 214 VALAAGASIAlrrKFSASGFLPD-------VRRYGAT--------YAnYVGKPLSYVlatpeRPDDAD--NPLRIVYgNE 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 311 AEPIDetaVQTFvdaGARFkmpaEC-VFPAYGMAEatLAVSFAplftgltldvveadaleaenRAVPVPEGDPRRGTDGV 389
Cdd:PRK07867 277 GAPGD---IARF---ARRF----GCvVVDGFGSTE--GGVAIT--------------------RTPDTPPGALGPLPPGV 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 390 rsfALLGrPLDGLE---AEIvDDAGKRVDEREVGE-IRLRGEAVTPGYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVI 464
Cdd:PRK07867 325 ---AIVD-PDTGTEcppAED-ADGRLLNADEAIGElVNTAGPGGFEGYYNDPEADAERMRGGVYWSGDLAYRdADGYAYF 399
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 465 CGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDAGSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAVD 544
Cdd:PRK07867 400 AGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVGDQVMAALVLAPGAKFDPDA---FAEFLAAQPDLGPK 476
                        410       420       430
                 ....*....|....*....|....*....|..
gi 300790052 545 MRPYAVVVlpAGSLPKTPSGKV-KRAATAQQF 575
Cdd:PRK07867 477 QWPSYVRV--CAELPRTATFKVlKRQLSAEGV 506
PRK07445 PRK07445
O-succinylbenzoic acid--CoA ligase; Reviewed
395-580 8.78e-07

O-succinylbenzoic acid--CoA ligase; Reviewed


Pssm-ID: 236019 [Multi-domain]  Cd Length: 452  Bit Score: 51.53  E-value: 8.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAgkrvdereVGEIRLRGEAVTPGYLtmdgPlATQDEDGWLNTGDLGYLV-DGQIVICGRRKDVII 473
Cdd:PRK07445 285 SGQVLPHAQITIPANQ--------TGNITIQAQSLALGYY----P-QILDSQGIFETDDLGYLDaQGYLHILGRNSQKII 351
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 474 MGGRNLYPTDIE---RAATSVEGV--------RAGNAVAvrldagsrrerfAVVLESKLAGDAEAEKNLMKQVSARVRda 542
Cdd:PRK07445 352 TGGENVYPAEVEaaiLATGLVQDVcvlglpdpHWGEVVT------------AIYVPKDPSISLEELKTAIKDQLSPFK-- 417
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 300790052 543 vdmRPYAVVVLPAgsLPKTPSGKVKRAATAQQFADRIK 580
Cdd:PRK07445 418 ---QPKHWIPVPQ--LPRNPQGKINRQQLQQIAVQRLG 450
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
161-570 2.13e-06

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 50.81  E-value: 2.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  161 TELAAAEPLPdVVVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDvDVMVSWLPTFHDMGMVGFLt 240
Cdd:PRK10252  582 APLAPQGAAP-LQLSQPHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTAD-DVVLQKTPCSFDVSVWEFF- 658
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  241 VPMTFGVELVkITPVEFLSGPLIWPELITKYHGTTTA-APNFAYAIVGrrmARVDEDDAYDLSKLRIALNGAEPIDETAV 319
Cdd:PRK10252  659 WPFIAGAKLV-MAEPEAHRDPLAMQQFFAEYGVTTTHfVPSMLAAFVA---SLTPEGARQSCASLRQVFCSGEALPADLC 734
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  320 QTFvdaGARFKMPaecVFPAYGMAEATLAVSFAPLFtgltldvveADALeAENRAVPVPEGDPRRGTdgvrsfallgrpl 399
Cdd:PRK10252  735 REW---QQLTGAP---LHNLYGPTEAAVDVSWYPAF---------GEEL-AAVRGSSVPIGYPVWNT------------- 785
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  400 dGLEaeIVDDAGKRVDEREVGEIRLRGEAVTPGYLT---------MDGPLAtQDEDGWLnTGDLG-YLVDGQIVICGRRK 469
Cdd:PRK10252  786 -GLR--ILDARMRPVPPGVAGDLYLTGIQLAQGYLGrpdltasrfIADPFA-PGERMYR-TGDVArWLDDGAVEYLGRSD 860
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  470 DVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRLDA------GSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAv 543
Cdd:PRK10252  861 DQLKIRGQRIELGEIDRAMQALPDVEQAVTHACVINQaaatggDARQLVGYLVSQSGLPLDTSA---LQAQLRERLPPH- 936
                         410       420
                  ....*....|....*....|....*..
gi 300790052  544 dMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:PRK10252  937 -MVPVVLLQLDQ--LPLSANGKLDRKA 960
PLN02614 PLN02614
long-chain acyl-CoA synthetase
171-527 2.20e-06

long-chain acyl-CoA synthetase


Pssm-ID: 166255 [Multi-domain]  Cd Length: 666  Bit Score: 50.79  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 171 DVVVTDEGDTALLQLTSGSTADPKAVRITYGN---LYSNVKAMVERAEFDFDV-DVMVSWLPTFHDM------------G 234
Cdd:PLN02614 216 DLPIKKKSDICTIMYTSGTTGDPKGVMISNESivtLIAGVIRLLKSANAALTVkDVYLSYLPLAHIFdrvieecfiqhgA 295
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 235 MVGFLTVPMTFGVE-LVKITPVEFLSGPLIWPELITKYHGTTT-----------AAPNFAYAIVGRRMARVDEDDAYD-- 300
Cdd:PLN02614 296 AIGFWRGDVKLLIEdLGELKPTIFCAVPRVLDRVYSGLQKKLSdggflkkfvfdSAFSYKFGNMKKGQSHVEASPLCDkl 375
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 301 -LSKL--------RIALNGAEPIdETAVQTFVdagarfKMPAEC-VFPAYGMAEATlAVSFAPLFTGL-TLDVVeadale 369
Cdd:PLN02614 376 vFNKVkqglggnvRIILSGAAPL-ASHVESFL------RVVACChVLQGYGLTESC-AGTFVSLPDELdMLGTV------ 441
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 370 aenrAVPVPEGDPRrgtdgvrsfallgrpldgLEA--EIVDDAgkrVDEREVGEIRLRGEAVTPGYLTMDGPLATQDEDG 447
Cdd:PLN02614 442 ----GPPVPNVDIR------------------LESvpEMEYDA---LASTPRGEICIRGKTLFSGYYKREDLTKEVLIDG 496
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 448 WLNTGDLG-YLVDGQIVICGRRKDVIIMG-GRNLYPTDIERAATSVEGVRA----GNA-----VAVRLDAGSRRERFAVv 516
Cdd:PLN02614 497 WLHTGDVGeWQPNGSMKIIDRKKNIFKLSqGEYVAVENIENIYGEVQAVDSvwvyGNSfesflVAIANPNQQILERWAA- 575
                        410
                 ....*....|.
gi 300790052 517 lESKLAGDAEA 527
Cdd:PLN02614 576 -ENGVSGDYNA 585
ttLC_FACS_like cd05915
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
176-568 3.15e-06

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.


Pssm-ID: 213283 [Multi-domain]  Cd Length: 509  Bit Score: 50.12  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 176 DEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFD-VDVMVSWLPTFHDMGMVGFLTVpMTFGVELVKITp 254
Cdd:cd05915  151 PERAACGMAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSeKDVVLPVVPMFHVNAWCLPYAA-TLVGAKQVLPG- 228
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 255 vEFLSGPLIWPELITKYHGTTTAAPNFAYAIVGrrmARVDEDDAYDLSkLRIALNGAEPIDetaVQTFVDAGARFK-MPA 333
Cdd:cd05915  229 -PRLDPASLVELFDGEGVTFTAGVPTVWLALAD---YLESTGHRLKTL-RRLVVGGSAAPR---SLIARFERMGVEvRQG 300
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 334 ECVFPAYGMAEATLAVSfaplftgltldvveadaleaENRAVPVPEGDPRRGTDGVRSFALLGRPLDGLEAEIVDDAgkr 413
Cdd:cd05915  301 YGLTETSPVVVQNFVKS--------------------HLESLSEEEKLTLKAKTGLPIPLVRLRVADEEGRPVPKDG--- 357
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 414 vdeREVGEIRLRGEAVTPGYLT-MDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRRKDVIIMGGRNLYPTDIERAATSV 491
Cdd:cd05915  358 ---KALGEVQLKGPWITGGYYGnEEATRSALTPDGFFRTGDIAVWdEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGH 434
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300790052 492 EGVRAGNAVAvRLDAGSRRERFAVVlesKLAgDAEAEKNLMKQVSARVRDAVDMRPYAVVVlpAGSLPKTPSGKVKR 568
Cdd:cd05915  435 PKVKEAAVVA-IPHPKWQERPLAVV---VPR-GEKPTPEELNEHLLKAGFAKWQLPDAYVF--AEEIPRTSAGKFLK 504
PRK08308 PRK08308
acyl-CoA synthetase; Validated
137-568 3.35e-06

acyl-CoA synthetase; Validated


Pssm-ID: 236231 [Multi-domain]  Cd Length: 414  Bit Score: 49.65  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 137 VLLGEPFDQLAPV--LEQKGIGFQLI---TELAAAEPLPDVV-----VTDEGDTA-------------LLQLTSGSTADP 193
Cdd:PRK08308  37 VCLKDPFDIITLVffLKEKGASVLPIhpdTPKEAAIRMAKRAgchglLYGESDFTkleavnylaeepsLLQYSSGTTGEP 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 194 KAVRITYGNLYSNVKAMVERAEFDFDVDVMVSwLPTFHDMGMVGFLTVPMTFGVElvkitpveflsgpliwPELITkyhg 273
Cdd:PRK08308 117 KLIRRSWTEIDREIEAYNEALNCEQDETPIVA-CPVTHSYGLICGVLAALTRGSK----------------PVIIT---- 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 274 ttTAAPNFAYAIVgrrmARVDEDDAYDLSKLRIALNGAEPIDET--AVQTfvdAGARfkMPAEC----------VFPAYG 341
Cdd:PRK08308 176 --NKNPKFALNIL----RNTPQHILYAVPLMLHILGRLLPGTFQfhAVMT---SGTP--LPEAWfyklrerttyMMQQYG 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 342 MAEATlAVSFAPlftgltlDVVEADALeaenrAVPVPEGDPRRGTDgvrsfalLGRPldgleAEIVDDAGKRvderevgE 421
Cdd:PRK08308 245 CSEAG-CVSICP-------DMKSHLDL-----GNPLPHVSVSAGSD-------ENAP-----EEIVVKMGDK-------E 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 422 IRlrgeavtpgyltmdgplatqdedgwlnTGDLGYLV-DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRagNAV 500
Cdd:PRK08308 293 IF---------------------------TKDLGYKSeRGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQ--EAV 343
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052 501 AVRLDAGSRRERFAVvlesklagdaeaeknlmkQVSAR-VRDAVDMRPYAVVVLPA----------GSLPKTPSGKVKR 568
Cdd:PRK08308 344 VYRGKDPVAGERVKA------------------KVISHeEIDPVQLREWCIQHLAPyqvpheiesvTEIPKNANGKVSR 404
MACS_euk cd05928
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...
395-569 3.64e-06

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.


Pssm-ID: 341251 [Multi-domain]  Cd Length: 530  Bit Score: 49.77  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTM---DGP---LATQDEDGWLnTGDLGYL-VDGQIVICGR 467
Cdd:cd05928  345 MGKASPPYDVQIIDDNGNVLPPGTEGDIGIRVKPIRPFGLFSgyvDNPektAATIRGDFYL-TGDRGIMdEDGYFWFMGR 423
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 468 RKDVIIMGGRNLYPTDIERAATSVEGVrAGNAVAVRLDA--GSRRERFAVVLESKLAGDAEAeknLMKQVSARVRDAVDM 545
Cdd:cd05928  424 ADDVINSSGYRIGPFEVESALIEHPAV-VESAVVSSPDPirGEVVKAFVVLAPQFLSHDPEQ---LTKELQQHVKSVTAP 499
                        170       180
                 ....*....|....*....|....
gi 300790052 546 RPYAVVVLPAGSLPKTPSGKVKRA 569
Cdd:cd05928  500 YKYPRKVEFVQELPKTVTGKIQRN 523
PTZ00237 PTZ00237
acetyl-CoA synthetase; Provisional
186-485 6.04e-06

acetyl-CoA synthetase; Provisional


Pssm-ID: 240325 [Multi-domain]  Cd Length: 647  Bit Score: 49.35  E-value: 6.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 186 TSGSTADPKA-VRITYGNL----YSNVKAMVERAEFDFDVDVMVSWLpTFHdMGMVGFLTVPMTFgvelvkitpVEFLSG 260
Cdd:PTZ00237 262 TSGTTGNSKAvVRSNGPHLvglkYYWRSIIEKDIPTVVFSHSSIGWV-SFH-GFLYGSLSLGNTF---------VMFEGG 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 261 PL--------IWpELITKYHGTTTaapnFAYAIVGRRMARVDED-----DAYDLSKLRIALNGAEPIDETaVQTFVDAga 327
Cdd:PTZ00237 331 IIknkhieddLW-NTIEKHKVTHT----LTLPKTIRYLIKTDPEatiirSKYDLSNLKEIWCGGEVIEES-IPEYIEN-- 402
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 328 rfKMPAECVfPAYGMAEatlavsfaplfTGLTLdVVEADALEAENRAVpvpegdprrgtdgvrsfallGRPLDGLEAEIV 407
Cdd:PTZ00237 403 --KLKIKSS-RGYGQTE-----------IGITY-LYCYGHINIPYNAT--------------------GVPSIFIKPSIL 447
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 408 DDAGKRVDEREVGEIRLRgeavtpgyLTMDGPLAT----QDED---------GWLNTGDLGYL-VDGQIVICGRRKDVII 473
Cdd:PTZ00237 448 SEDGKELNVNEIGEVAFK--------LPMPPSFATtfykNDEKfkqlfskfpGYYNSGDLGFKdENGYYTIVSRSDDQIK 519
                        330
                 ....*....|..
gi 300790052 474 MGGRNLYPTDIE 485
Cdd:PTZ00237 520 ISGNKVQLNTIE 531
prpE PRK10524
propionyl-CoA synthetase; Provisional
459-570 1.22e-05

propionyl-CoA synthetase; Provisional


Pssm-ID: 182517 [Multi-domain]  Cd Length: 629  Bit Score: 48.02  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 459 DGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRlDA--GSRRERFAVVLESKLAGDAEA----EKNLM 532
Cdd:PRK10524 486 DGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVVGVK-DAlkGQVAVAFVVPKDSDSLADREArlalEKEIM 564
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 300790052 533 KQVSARVrDAVdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:PRK10524 565 ALVDSQL-GAV-ARPARVWFVSA--LPKTRSGKLLRRA 598
A_NRPS_ProA cd17656
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ...
395-570 1.38e-05

gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341311 [Multi-domain]  Cd Length: 479  Bit Score: 47.85  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVTPGYLTMDgPLATQ-------DEDGWL-NTGDLG-YLVDGQIVIC 465
Cdd:cd17656  303 IGKPISNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQ-ELTAEkffpdpfDPNERMyRTGDLArYLPDGNIEFL 381
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 466 GRRKDVIIMGGRNLYPTDIERAATSVEGVRAGnAVAVRLDAGSRRERFAVVLESKLAGDAEAEKNLMKQVSARvrdavdM 545
Cdd:cd17656  382 GRADHQVKIRGYRIELGEIEAQLLNHPGVSEA-VVLDKADDKGEKYLCAYFVMEQELNISQLREYLAKQLPEY------M 454
                        170       180
                 ....*....|....*....|....*
gi 300790052 546 RPYAVVvlPAGSLPKTPSGKVKRAA 570
Cdd:cd17656  455 IPSFFV--PLDQLPLTPNGKVDRKA 477
MACS_like_1 cd05974
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
395-568 3.15e-05

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341278 [Multi-domain]  Cd Length: 432  Bit Score: 46.79  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAGKRVDErevGEIRLRGEAVTP-----GYLTMDGPLATQDEDGWLNTGDLGYL-VDGQIVICGRR 468
Cdd:cd05974  254 MGRPLPGYRVALLDPDGAPATE---GEVALDLGDTRPvglmkGYAGDPDKTAHAMRGGYYRTGDIAMRdEDGYLTYVGRA 330
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 469 KDVIIMGGRNLYPTDIERAATSVEGVrAGNAVAVRLDAgsrrERFAV----VLeskLAGDAEAEKNLMKQVSARVRDAvd 544
Cdd:cd05974  331 DDVFKSSDYRISPFELESVLIEHPAV-AEAAVVPSPDP----VRLSVpkafIV---LRAGYEPSPETALEIFRFSRER-- 400
                        170       180
                 ....*....|....*....|....*
gi 300790052 545 MRPYAVVV-LPAGSLPKTPSGKVKR 568
Cdd:cd05974  401 LAPYKRIRrLEFAELPKTISGKIRR 425
ACS cd05966
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...
396-568 4.12e-05

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.


Pssm-ID: 341270 [Multi-domain]  Cd Length: 608  Bit Score: 46.40  E-value: 4.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 396 GRPLDGLEAEIVDDAGKRVDEREVGEIRLR----GEAVT----------------PG-YLTMDGplATQDEDGWlntgdl 454
Cdd:cd05966  413 TRPFFGIEPAILDEEGNEVEGEVEGYLVIKrpwpGMARTiygdheryedtyfskfPGyYFTGDG--ARRDEDGY------ 484
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 455 gylvdgqIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVrAGNAVAVRLDAGSRRERFA-VVLESKLAGDAEAEKNLMK 533
Cdd:cd05966  485 -------YWITGRVDDVINVSGHRLGTAEVESALVAHPAV-AEAAVVGRPHDIKGEAIYAfVTLKDGEEPSDELRKELRK 556
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 300790052 534 QVSARVRdavdmrPYAV--VVLPAGSLPKTPSGKVKR 568
Cdd:cd05966  557 HVRKEIG------PIATpdKIQFVPGLPKTRSGKIMR 587
PRK05691 PRK05691
peptide synthase; Validated
33-570 8.18e-05

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 45.93  E-value: 8.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052   33 TWAEVHEEARRIAGGLVAGGFERGTAVGVLAAAPVLIAPTVQAVWLAGGSVTMLHQPTPRTDLAEWAEDT-VRVLGMIGS 111
Cdd:PRK05691 1158 DYAELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPDYPAERLAYMLADSgVELLLTQSH 1237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  112 DQDALGGPGGLAPRPgsgagprnvtvllgepFDQLapvleqkgigfqlitELAAAEPLPDVVVTDEGDTALLQLTSGSTA 191
Cdd:PRK05691 1238 LLERLPQAEGVSAIA----------------LDSL---------------HLDSWPSQAPGLHLHGDNLAYVIYTSGSTG 1286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  192 DPKAVRITYGNLYSNVKAMveRAEFDFDV-DVMVSWLPTFHDMGmVGFLTVPMTFGVELVKITPVEFlSGPLIWPELITK 270
Cdd:PRK05691 1287 QPKGVGNTHAALAERLQWM--QATYALDDsDVLMQKAPISFDVS-VWECFWPLITGCRLVLAGPGEH-RDPQRIAELVQQ 1362
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  271 YHGTTTaapNFAYAIVgrrMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFVDagarfKMPAECVFPAYGMAEATLAVS 350
Cdd:PRK05691 1363 YGVTTL---HFVPPLL---QLFIDEPLAAACTSLRRLFSGGEALPAELRNRVLQ-----RLPQVQLHNRYGPTETAINVT 1431
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  351 FAPLftgltldvveadaleaenravpvpegdprRGTDGVRSfaLLGRPLDGLEAEIVDDAGKRVDEREVGEIRLRGEAVT 430
Cdd:PRK05691 1432 HWQC-----------------------------QAEDGERS--PIGRPLGNVLCRVLDAELNLLPPGVAGELCIGGAGLA 1480
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052  431 PGYLTMDGPLATQ---DEDG-----WLNTGDLG-YLVDGQIVICGRRKDVIIMGGRNLYPTDIERAATSVEGVRAGnAVA 501
Cdd:PRK05691 1481 RGYLGRPALTAERfvpDPLGedgarLYRTGDRArWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQA-AVL 1559
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300790052  502 VRLDAGSRRerfAVVLESKLAGDAEAEKNLMKQVSARVRDAvdMRPYAVVVLPAgsLPKTPSGKVKRAA 570
Cdd:PRK05691 1560 VREGAAGAQ---LVGYYTGEAGQEAEAERLKAALAAELPEY--MVPAQLIRLDQ--MPLGPSGKLDRRA 1621
PRK04319 PRK04319
acetyl-CoA synthetase; Provisional
395-568 8.78e-05

acetyl-CoA synthetase; Provisional


Pssm-ID: 235279 [Multi-domain]  Cd Length: 570  Bit Score: 45.27  E-value: 8.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 395 LGRPLDGLEAEIVDDAGKRVDEREVGEIRLRgeavtPGYLTMDGPLATQDE-------DGWLNTGDLGYL-VDGQIVICG 466
Cdd:PRK04319 378 MGKPLPGIEAAIVDDQGNELPPNRMGNLAIK-----KGWPSMMRGIWNNPEkyesyfaGDWYVSGDSAYMdEDGYFWFQG 452
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 467 RRKDVIIMGGRNLYPTDIERA-----ATSVEGVrAGNAVAVRldaGSRRERFaVVLESKLAGDAEAEKNLMKQVSARVRD 541
Cdd:PRK04319 453 RVDDVIKTSGERVGPFEVESKlmehpAVAEAGV-IGKPDPVR---GEIIKAF-VALRPGYEPSEELKEEIRGFVKKGLGA 527
                        170       180
                 ....*....|....*....|....*..
gi 300790052 542 AVDMRPYAVvvlpAGSLPKTPSGKVKR 568
Cdd:PRK04319 528 HAAPREIEF----KDKLPKTRSGKIMR 550
FATP_FACS cd05940
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...
179-504 1.27e-04

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341263 [Multi-domain]  Cd Length: 449  Bit Score: 44.65  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 179 DTALLQLTSGSTADPKAVRITYGNLYsNVKAMVERAEFDFDVDVMVSWLPTFHDMG-MVGFLTVPMTfGVELV---KITP 254
Cdd:cd05940   82 DAALYIYTSGTTGLPKAAIISHRRAW-RGGAFFAGSGGALPSDVLYTCLPLYHSTAlIVGWSACLAS-GATLVirkKFSA 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 255 VEFlsgpliWPELItKYHGTTtaapnFAYaiVG---RRMARVDEDDAYDLSKLRIAL-NGAEPidetavQTFVDAGARFK 330
Cdd:cd05940  160 SNF------WDDIR-KYQATI-----FQY--IGelcRYLLNQPPKPTERKHKVRMIFgNGLRP------DIWEEFKERFG 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 331 MPAECVFpaYGMAEATL----------AVSFAP--LFTGLTLDVVEADaleaenravpVPEGDPRRGTDGVrsfallgrp 398
Cdd:cd05940  220 VPRIAEF--YAATEGNSgfinffgkpgAIGRNPslLRKVAPLALVKYD----------LESGEPIRDAEGR--------- 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 399 ldgleaeivddaGKRVDEREVGEIRLRGEAVTP--GYLtmdGPLATQ---------DEDGWLNTGDLGYLVD-GQIVICG 466
Cdd:cd05940  279 ------------CIKVPRGEPGLLISRINPLEPfdGYT---DPAATEkkilrdvfkKGDAWFNTGDLMRLDGeGFWYFVD 343
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 300790052 467 RRKDVIIMGGRNLYPTDIERAATSVEGVRAGNAVAVRL 504
Cdd:cd05940  344 RLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQV 381
A_NRPS_Bac cd17655
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ...
173-570 1.96e-04

bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341310 [Multi-domain]  Cd Length: 490  Bit Score: 44.24  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 173 VVTDEGDTALLQLTSGSTADPKAVRITYGNLYSNVKAMVERAEFDFDVDVMVswLPTFHDMGMVGFLTVPMTFGVELVKI 252
Cdd:cd17655  132 PVSKSDDLAYVIYTSGSTGKPKGVMIEHRGVVNLVEWANKVIYQGEHLRVAL--FASISFDASVTEIFASLLSGNTLYIV 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 253 TPVEFLSGPLIWPELITKYHGTTTAAPNFayaivgrrMARVDEDDAYDLSKLRIALNGAEPIDETAVQTFvdaGARFKMP 332
Cdd:cd17655  210 RKETVLDGQALTQYIRQNRITIIDLTPAH--------LKLLDAADDSEGLSLKHLIVGGEALSTELAKKI---IELFGTN 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 333 AEcVFPAYGMAEATLavsfaplftGLTLDVVEadalEAENRAVPVPegdprrgtdgvrsfalLGRPLDGLEAEIVDDAGK 412
Cdd:cd17655  279 PT-ITNAYGPTETTV---------DASIYQYE----PETDQQVSVP----------------IGKPLGNTRIYILDQYGR 328
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 413 RVDEREVGEIRLRGEAVTPGYLT---------MDGPLA-------TQDEDGWLNTGDLGYL--VDGQIVICGRRkdvIIM 474
Cdd:cd17655  329 PQPVGVAGELYIGGEGVARGYLNrpeltaekfVDDPFVpgermyrTGDLARWLPDGNIEFLgrIDHQVKIRGYR---IEL 405
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 475 GgrnlyptDIERAATSVEGVRAGnAVAVRLDagsrrERFAVVLESKLAGDAEAEKNLMKQVSARvrdavDMRPYAVvvlP 554
Cdd:cd17655  406 G-------EIEARLLQHPDIKEA-VVIARKD-----EQGQNYLCAYIVSEKELPVAQLREFLAR-----ELPDYMI---P 464
                        410       420
                 ....*....|....*....|.
gi 300790052 555 A-----GSLPKTPSGKVKRAA 570
Cdd:cd17655  465 SyfiklDEIPLTPNGKVDRKA 485
PRK12582 PRK12582
acyl-CoA synthetase; Provisional
132-459 2.64e-04

acyl-CoA synthetase; Provisional


Pssm-ID: 237144 [Multi-domain]  Cd Length: 624  Bit Score: 43.88  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 132 PRNVTVLLGEPFDQLAPVLEQKGIgfQLITELAAAE-----PLPDVV---VTDEGDTALLQL----------TSGSTADP 193
Cdd:PRK12582 158 PRVVFAQSGAPFARALAALDLLDV--TVVHVTGPGEgiasiAFADLAatpPTAAVAAAIAAItpdtvakylfTSGSTGMP 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 194 KAVRITYGNLYSNVKAM--VERAEFDFDVDVMVSWLPTFHDM-GMVGFLTV-------------PMTFGVE-----LVKI 252
Cdd:PRK12582 236 KAVINTQRMMCANIAMQeqLRPREPDPPPPVSLDWMPWNHTMgGNANFNGLlwgggtlyiddgkPLPGMFEetirnLREI 315
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 253 TPVEFLSGPLiwpelitkyhgtttaapnfAYAIVGRRMARVDEDDAYDLSKLR-IALNGA-------EPIDETAVQTfvd 324
Cdd:PRK12582 316 SPTVYGNVPA-------------------GYAMLAEAMEKDDALRRSFFKNLRlMAYGGAtlsddlyERMQALAVRT--- 373
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300790052 325 AGARFKmpaecVFPAYGMAEAtlavsfAPLFTGLTLDvveadaleaenravpvpegdprrgTDGVrsfALLGRPLDGLEA 404
Cdd:PRK12582 374 TGHRIP-----FYTGYGATET------APTTTGTHWD------------------------TERV---GLIGLPLPGVEL 415
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 300790052 405 EIVDDAGKRvderevgEIRLRGEAVTPGYLTM-DGPLATQDEDGWLNTGDLGYLVD 459
Cdd:PRK12582 416 KLAPVGDKY-------EVRVKGPNVTPGYHKDpELTAAAFDEEGFYRLGDAARFVD 464
 
Blast search parameters
Data Source: Live blast search RID = SJFAGJB8016
User Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01   Maximum number of hits: 500

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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