|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-860 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1580.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 81 AFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCP 160
Cdd:COG0495 81 AFGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 161 NDQTVLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSVGVEISFDVNDYA 240
Cdd:COG0495 161 VDQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDGWPEKVKTMQRNWIGRSEGAEVDFPVEGSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 241 DKLTVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPAL--AAFIDECRNTKVAEADMATMEKKGVDTGFKAIHPLTGEQI 318
Cdd:COG0495 241 EKITVFTTRPDTLFGATFMVLAPEHPLVKELATPEQNAavAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 319 PVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSEQALTEKGVLFNSGEFSGLDYEAGFNA 398
Cdd:COG0495 321 PIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGDDPDILEEAYTGDGVLINSGEFDGLDSEEAKEA 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 399 IADKLAAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVLPTPEDQLPVILPEDVVMDGI-TSPIKADPEWAKTT 477
Cdd:COG0495 401 IIEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDPTgGSPLARAPEWVNVT 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 478 --VNGQPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVN 555
Cdd:COG0495 481 cpKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVS 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 556 SDEPAKQLLCQGMVLAdafyyVGENGErnwvspvdaiverdekgrivkakdaaghelVYTGMSKMSKSKNNGIDPQVMVE 635
Cdd:COG0495 561 FDEPFKRLLTQGMVLE-----VGKDGV------------------------------VIGGIEKMSKSKGNVVDPDEIIE 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 636 RYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTTKGevaALNVAALSEDQKALRRDIHKTIAKVTDD 715
Cdd:COG0495 606 KYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEAL---KLDVADLSEADKELRRALHKTIKKVTED 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 716 IGrRQTFNTAIAAIMELMNKLAKAPQEDEQDRALMQEALLAVVRMLNPFTPHASFTLWRELNGEGDIDNAPWPVADESAM 795
Cdd:COG0495 683 IE-RLRFNTAIAALMELVNALYKAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAAL 761
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378977672 796 VEDSTLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLDGKTVRKVIYVPGKLLNLVVG 860
Cdd:COG0495 762 VEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
5-860 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1437.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 5 YRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 85 PAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQT 164
Cdd:TIGR00396 81 PAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 165 VLANEQVI-DGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSVGVEISFDVNDYADKL 243
Cdd:TIGR00396 161 VLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPESVKEMQRNWIGKSEGVEITFKIADHDEKI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 244 TVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPALAAFIDECRNTKVAEADMATMEKKGVDTGFKAIHPLTGEQIPVWAA 323
Cdd:TIGR00396 241 TVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPIWVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 324 NFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPdlSEQALTEKGVLFNSGEFSGLDYEAGFNAIADKL 403
Cdd:TIGR00396 321 NYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKDLS--LTAAYTEDGVLVNSGEFNGLNSSEARNAIIDML 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 404 AAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVLPTPEDQLPVILPEDVVMDGI-TSPIKADPEWAKTTVN--G 480
Cdd:TIGR00396 399 EKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDgGSPLSRIPEWVNVTCPscG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 481 QPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVNSDEPA 560
Cdd:TIGR00396 479 KPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPF 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 561 KQLLCQGMVLAdafYYVGENGErnwvSPVDAIVERDEKGrivkaKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGAD 640
Cdd:TIGR00396 559 KKLINQGMVLG---FYYPPNGK----VPADVLTERDEKG-----KDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGAD 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 641 TVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTTKGEVAALNVAALSEDQKALRRDIHKTIAKVTDDIGRRQ 720
Cdd:TIGR00396 627 ALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLEKRE 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 721 TFNTAIAAIMELMNKLAKAPQEdeqdrALMQEALLAVVRMLNPFTPHASFTLWRELN-GEGDIDNAPWPVADESAMVEDS 799
Cdd:TIGR00396 707 SFNTAISAMMELLNKLYKAKKE-----ALMLEYLKGFVTVLSPFAPHLAEELWEKLGsEPFIIDNAKWPVVDETALVEDK 781
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378977672 800 TLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLDGKTVRKVIYVPGKLLNLVVG 860
Cdd:TIGR00396 782 TLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-860 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 877.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 9 EIESKVQLHWDENRTFEVTE--DESKEKYYCLSMLPYPSGR-LHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLP 85
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRTPDdvDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLP 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 86 AEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTV 165
Cdd:PLN02563 164 AEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTV 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 166 LANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDhWPDTVKTMQRNWIGRSVGVEISFDVNDYA----- 240
Cdd:PLN02563 244 LANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLD-WPESIKEMQRNWIGRSEGAELDFSVLDGEgkerd 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 241 DKLTVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPALAafIDECRNTKVAEADM----ATMEKKGVDTGFKAIHPLTGE 316
Cdd:PLN02563 323 EKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEA--VEEYVDAASRKSDLerteLQKEKTGVFTGSYAINPATGE 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 317 QIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDlSEQALTEKGVLFNSGE----FSGLDY 392
Cdd:PLN02563 401 AIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDD-AEKAYTGEGVIVNSSSsgldINGLSS 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 393 EAGFNAIADKLAAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLED-GTVLPTPEDQLPVILPEdvvMDGIT------S 465
Cdd:PLN02563 480 KEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDsGEPVPVPESDLPLTLPE---LDDFTptgtgeP 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 466 PIKADPEWAKTT--VNGQPALRETDTFDTFMESSWYYARYTCPQYQEGMLDSKAANYWLPVDIYIGGIEHAIMHLLYFRF 543
Cdd:PLN02563 557 PLAKAVSWVNTVdpSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARF 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 544 FHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGRIVKAKDAA--GHELVYTG----- 616
Cdd:PLN02563 637 WHKVLYDIGVVSTKEPFQCLVNQGMILGEVEYTAFKDSDGEYVSADTADRLGELQQEKIPEEKVIksGDSFVLKDdpsir 716
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 617 ----MSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVY-EHTTKGEVAALNV 691
Cdd:PLN02563 717 liarAHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVgAPLPDGSFRDGTV 796
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 692 AALSEDQKALRRDIHKTIAKVTDDI-GRRqtFNTAIAAIMELMNKLAKapqEDEQDRalmqEALLAVVRMLNPFTPHASF 770
Cdd:PLN02563 797 VTDEEPSLEQLRLLHKCIAKVTEEIeSTR--FNTAISAMMEFTNAAYK---WDKVPR----EAIEPFVLLLSPYAPHLAE 867
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 771 TLWRELNGEGDIDNAPWPVADESAMVEDSTLVVVQVNGKVRGKITVAVDATEEQVRERAGQEHLVAKYLDGKTVRKVIYV 850
Cdd:PLN02563 868 ELWFRLGHSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYV 947
|
890
....*....|
gi 378977672 851 PGKLLNLVVG 860
Cdd:PLN02563 948 PGKILNVILK 957
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-658 |
3.24e-121 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 368.88 E-value: 3.24e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:cd00812 1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 114 MLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCpndqtvlaneqvidgccwrcdtkverKEIPQWFI 193
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 194 KI--TAYADELLNDLdkldhwpdtvktmqrnwigrsvgveisfdvndyadkltvyttrpdtfmgctylavaaghplaqqa 271
Cdd:cd00812 135 KYseTEWKEKLLKDL----------------------------------------------------------------- 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 272 aannpalaafidecrntkvaeadmatmekkgvdtgfkaihpltgEQIPVWAANFVLMeygtgavmavpghdqrdyefask 351
Cdd:cd00812 150 --------------------------------------------EKLDGWPEEVRAM----------------------- 162
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 352 yglnikpvilaadgsepdlseqaltekgvlfnsgefsgldyeagfnaiadklaamgvgerkvnyrLRDW-GVSRQRYWGA 430
Cdd:cd00812 163 -----------------------------------------------------------------QENWiGCSRQRYWGT 177
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 431 PIPMvtledgtvlptpedqlpvilpedvvmdgitspikadpewakttvngqpalreTDTFDTFMESSWYYARYTCPQYQE 510
Cdd:cd00812 178 PIPW----------------------------------------------------TDTMESLSDSTWYYARYTDAHNLE 205
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 511 GML------DSKAANYWLPVDIYIGGIEHAIMHLLYFRFFHKLMRDAGMVnSDEPAKQLLCQGMVLAdafyyvgeNGErn 584
Cdd:cd00812 206 QPYegdlefDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLL--------EGE-- 274
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378977672 585 wvspvdaiverdekgrivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEW 658
Cdd:cd00812 275 ----------------------------------KMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
221-404 |
1.47e-103 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 317.95 E-value: 1.47e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 221 RNWIGRSVGVEISFDVNDYADKLTVYTTRPDTFMGCTYLAVAAGHPLAQQAAANNPALAAFIDECRNTKVAEADMATMEK 300
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAFIEECKNTSEIERTSETKEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 301 KGVDTGFKAIHPLTGEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSE-PDLSEQALTEKG 379
Cdd:pfam13603 81 EGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDGDLdLDIMTEAYTEEG 160
|
170 180
....*....|....*....|....*
gi 378977672 380 VLFNSGEFSGLDYEAGFNAIADKLA 404
Cdd:pfam13603 161 ILVNSGEFDGLDSEEAKEAIIKKLE 185
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-852 |
1.03e-92 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 311.22 E-value: 1.03e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 81 AFGLPAEGAAVKNNTAPAP----------------WTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELY 144
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAEGKtkhdlgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 145 KKGLVYKKTSAVNWCPNDQTVLANEQvidgccwrcdtkVERKEIPQ--WFIKItayadellndldKLDhwpdtvktmqrn 222
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIE------------VEYKEVKGklYYIRY------------PLA------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 223 wigrsvgveisfdvNDYADKLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpalaafiDECRNTkvaeadmaTMEKKg 302
Cdd:TIGR00422 205 --------------NGSKDYLVVATTRPETMFGDTAVAV---HP----------------EDERYK--------HLIGK- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 303 vdtgfKAIHPLTGEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLnikPVILaadgsepdlseqALTEKGVLF 382
Cdd:TIGR00422 243 -----KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNL---EFIN------------ILDEDGLLN 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 383 -NSGEFSGLDYEAGFNAIADKLAA-------------MGVGER------------------------------------- 411
Cdd:TIGR00422 303 eNAGKYQGLTRFEARKKIVEDLKEegllvkiephthnVGTCWRsgtvvepllskqwfvkvekladkaleaaeegeikfvp 382
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 412 ---KVNYR-----LRDWGVSRQRYWGAPIPMVTledgtvlptpedqlpvILPEDVVMDGITSPIKADPEWAKTTVNGQPa 483
Cdd:TIGR00422 383 krmEKRYLnwlrnIKDWCISRQLIWGHRIPVWY----------------CKECGEVYVAKEEPLPDDKTNTGPSVELEQ- 445
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 484 lrETDTFDTFMeSSWYYARYTC--PQyqegmLDSKAANYWlPVDIYIGGieHAImhlLYFRFFHKLMRdaGMVNSDE-PA 560
Cdd:TIGR00422 446 --DTDVLDTWF-SSSLWPFSTLgwPD-----ETKDLKKFY-PTDLLVTG--YDI---IFFWVARMIFR--SLALTGQvPF 509
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 561 KQLLCQGMVladafyyvgengernwvspvdaiveRDEKGRivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGAD 640
Cdd:TIGR00422 510 KEVYIHGLV-------------------------RDEQGR------------------KMSKSLGNVIDPLDVIEKYGAD 546
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 641 TVRLFMMFASPADMTLEWQESGVEGANRFLKRVW---KLVYEHTT-KGEVAALNVAALSEDQKALRRdIHKTIAKVTDDI 716
Cdd:TIGR00422 547 ALRFTLASLVTPGDDINFDWKRVESARNFLNKLWnasRFVLMNLSdDLELSGGEEKLSLADRWILSK-LNRTIKEVRKAL 625
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 717 GRRQtFNTAIAAIMEL-----------MNKLAKAPQEDEQDRALMQEA---LLAVVRMLNPFTPHASFTLWRELNGEGD- 781
Cdd:TIGR00422 626 DKYR-FAEAAKALYEFiwndfcdwyieLVKYRLYNGNEAEKKAARDTLyyvLDKALRLLHPFMPFITEEIWQHFKEGADs 704
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 782 IDNAPWPVADESAM---VEDSTLVVVQVNGKVR-----------GKITVAVDATEEQVRERAG-QEHLVAKYLDGKTVRK 846
Cdd:TIGR00422 705 IMLQSYPVVDAEFVdeeAEKAFELLKEIIVSIRnlkaesnippnAPLKVLLIYTEAETAERLKlNAVDIKGAINFSEVEV 784
|
....*.
gi 378977672 847 VIYVPG 852
Cdd:TIGR00422 785 VIEKPE 790
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-827 |
1.42e-82 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 282.08 E-value: 1.42e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 81 AFGLPAEgaaVK----NNTAPAP------------WTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELY 144
Cdd:PRK13208 86 DNGLPTE---RKvekyYGIRKDDisreefielcreLTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 145 KKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEIPqwfikiTAYADellndldkldhwpdtvktmqrnwi 224
Cdd:PRK13208 163 KKGLIYRAEAPVLWCPRCETAIA------------QAEVEYRERE------GKLNY------------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 225 grsvgveISFDVNDyADKLTVYTTRPDTFMGCtyLAVAAgHPLaqqaaannpalaafiDEcRNTKVAeadmatmekkgvd 304
Cdd:PRK13208 201 -------IKFPVED-GEEIEIATTRPELLPAC--VAVVV-HPD---------------DE-RYKHLV------------- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 305 tGFKAIHPLTGEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVIlaadgsepdlseqalTEKGVLF-N 383
Cdd:PRK13208 241 -GKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIII---------------DEDGRMTeA 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 384 SGEFSGLDYEAGFNAIADKLAAMG-VGE-----RKVN-----------------------------------------YR 416
Cdd:PRK13208 305 AGKLAGLTIEEARKKIVEDLKSGGlLGKqepikHNVKfcercdtpleilvtrqwfikvldlkeellergkeinwypehMR 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 417 LR----------DWGVSRQRYWGAPIPM-VTLEDGTVLPTPEDQLPVilpeDvvmdgitsPIKADPEWAKTTVNGQPALR 485
Cdd:PRK13208 385 VRlenwieglnwDWCISRQRYFGTPIPVwYCKDCGHPILPDEEDLPV----D--------PTKDEPPGYKCPQCGSPGFE 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 486 -ETDTFDTFMESSwyyaryTCPQYQEG-MLDSKAANYWLPVDIYIGGieHAIMhllyfRF--FHKLMRdAGMVNSDEPAK 561
Cdd:PRK13208 453 gETDVMDTWATSS------ITPLIVTGwERDEDLFEKVFPMDLRPQG--HDII-----RTwlFYTILR-AYLLTGKLPWK 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 562 QLLCQGMVLadafyyvgengernwvspvdaiverDEKGRivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGADT 641
Cdd:PRK13208 519 NIMISGMVL-------------------------DPDGK------------------KMSKSKGNVVTPEELLEKYGADA 555
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 642 VRLFMMFASP-ADMTLEWQEsgVEGANRFLKRVW---KLVYehtTKGEVAALNVAALSE--DQKALRRdIHKTIAKVTDD 715
Cdd:PRK13208 556 VRYWAASARLgSDTPFDEKQ--VKIGRRLLTKLWnasRFVL---HFSADPEPDKAEVLEplDRWILAK-LAKVVEKATEA 629
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 716 IGRRQtFNTAIAAIM------------ELMNKLAKAPQEDEQD---RALMQEALLAVVRMLNPFTPHASFTLWRELNGeG 780
Cdd:PRK13208 630 LENYD-FAKALEEIEsffwhvfcddylELVKSRAYGEDEEEEQksaRYTLYTVLDTLLRLLAPFLPFITEEVWSWLYG-G 707
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378977672 781 DIDNAPWPVADESAMVEDSTLV---VVQVNGKVRG--------------KITVAVDATEEQVRE 827
Cdd:PRK13208 708 SVHRASWPEPDEELIDEEDEELgelAKEILSAVRKykseaglslnaplkKVEVYGPADLELLEA 771
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-651 |
3.61e-59 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 212.66 E-value: 3.61e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 13 KVQLHWDENRTFEVTEDESKEK-YYCLSM-LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA 90
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKpSFTIHDgPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 91 VKNNTAPAP-----------------WTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKT 153
Cdd:pfam00133 81 EKKLGIKEKktrhkygreefrekcreWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 154 SAVNWCPNDQTVLANeqvidgccwrcdTKVERKEIpqwfikitayadellndldkldhwpdtvktmqrnwigRSVGVEIS 233
Cdd:pfam00133 161 KLVNWSPALNTALSN------------LEVEYKDV-------------------------------------KGPSIHVA 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 234 FDVNDYAD-KLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpaLAAFIDECRNTKVAEADMATMEKKGVDT------- 305
Cdd:pfam00133 192 FPLADDEGaSLVIWTTTPWTLPGNTAVAV---NP-----------EFDYVITGEGYILAEALLKSLYKKGTDKkiledfr 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 306 -----GFKAIHPLTGEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIkPVILAADG----SEPDLSEQ--- 373
Cdd:pfam00133 258 gkeleGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEV-INPVDDDGtfteEAPDFQGVyrf 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 374 --------ALTEKGVLFNSGEF---------SG--LDYEA--GFNAIADKLAAMGVGE-RKVNY--------------RL 417
Cdd:pfam00133 337 darkkiveLLTEKGLLLKIEPFthsypfcwrSGtpIIPRAtpQWFVRMDELADQALEAvEKVQFvpksgekryfnwlaNI 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 418 RDWGVSRQRYWGAPIPMVTLEDGtvlptpedqlpvilpEDVVMDGITSPIKADPE--------WAKTTVN--GQPAL--- 484
Cdd:pfam00133 417 QDWCISRQRWWGHPIPAWVSKDT---------------EEVVCRGELFELVAGRFeeegsikwLHREAKDklGYGKGtle 481
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 485 RETDTFDTFMES-SWYYARYTCPQYQEGMLDSkaanyWLPVDIYIGGIEhaimhLLYFRFFHKLMRDAGMVNSdEPAKQL 563
Cdd:pfam00133 482 QDEDVLDTWFSSgSWPFSTLGWPFVNTEEFKK-----FFPADMLLEGSD-----QTRGWFYRMIMLSTALTGS-VPFKNV 550
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 564 LCQGMVladafyyvgengernwvspvdaiveRDEKGRivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVR 643
Cdd:pfam00133 551 LVHGLV-------------------------RDEQGR------------------KMSKSLGNVIDPLDVIDKYGADALR 587
|
....*...
gi 378977672 644 LFMMFASP 651
Cdd:pfam00133 588 LWLANSDY 595
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
3-794 |
2.89e-57 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 211.46 E-value: 2.89e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 3 EQYRPEEIESKVQLHWDENRTFEVTED--ESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVKKlnKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 81 AFGLPAEGAAVKNNtaPAPWTYD-------------------NIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFT 141
Cdd:TIGR00392 84 THGLPIEHKVEKKL--GISGKKEissleieefrekcrefalkQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 142 ELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRcdtkveRKEIPQWFIKITAYADELLNDLDKLDH---WPDTVKT 218
Cdd:TIGR00392 162 EAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYK------DVKDPSIYVKFPVKKDKKTYLKVKLSSlliWTTTPWT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 219 MQRNwigRSVGVEISFDvndYAdkLTVYTTRPDTFMgctyLAVAAGHPLAQQAAANNPALAAFidecrntkvaeadmatm 298
Cdd:TIGR00392 236 LPSN---LAIAVHPDFE---YA--LVQDNTKVEYFI----LAKKLVEKLYNKAGSDYEIIKTF----------------- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 299 ekKGVD-TGFKAIHPLTG--EQIPVWA-----ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNI-KPV---------- 359
Cdd:TIGR00392 287 --KGSDlEGLEYEHPLYDfvSQLKEGApvvigGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlSPVdekgvytegv 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 360 --------------ILAADgsepDLSEQALTEKGVLFNSGEFS---GLDY-----------EAGF---NAIADK-LAAMG 407
Cdd:TIGR00392 365 ndfqgrfvkdadkdIIKAN----KIIIEQLKDKGLLLKAEKIThsyPHCWrtktpviyratEQWFiktKDIKDQmLEQIK 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 408 vgerKVNY-------RL-------RDWGVSRQRYWGAPIPMVTLEDGtvlptpeDQLPVI-----LPEDVVMDGITSPIK 468
Cdd:TIGR00392 441 ----KVNWvpewgegRFgnwlenrPDWCISRQRYWGIPIPIWYCEDT-------GEPIVVgsieeLIELIELKGIDAWFE 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 469 ADP----EWAKTT-VNGQPALRETDTFDTFMES-SWYYARYtcpQYQEGMLDSKAanyWLPVDIYIGGIEHaimhllYFR 542
Cdd:TIGR00392 510 DLHrdflDKITLKsGDGGEYRRVPDVLDVWFDSgSMPYASI---HYPFENEKFKE---VFPADFILEGSDQ------TRG 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 543 FFHKLMRDAGMVNSDEPAKQLLCQGMVLadafyyvgengernwvspvdaiverDEKGRivkakdaaghelvytgmsKMSK 622
Cdd:TIGR00392 578 WFYSSLAIGTALFGQAPYKNVITHGFTL-------------------------DEKGR------------------KMSK 614
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 623 SKNNGIDPQVMVERYGADTVRLFMMFASPADmTLEWQESGVEGANRFLKRVWKLVYE--------HTTKGEVAALNVAAL 694
Cdd:TIGR00392 615 SLGNVVDPLKVINKYGADILRLYVASSDPWE-DLRFSDEILKQVVEKYRKIRWNTYRflltyanlDKFDPLFNSVAVEKF 693
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 695 S-EDQKALRRdIHKTIAKVTDDIGRRQtFNTAIAAIMELMNK--------LAK----APQEDEQDRA---LMQEALLAVV 758
Cdd:TIGR00392 694 PeEDRWILSR-LNSLVEEVNEALEKYN-FHKVLRALQDFIVEelsnwyirIIRdrlyCEAKDNDKRAaqtTLYYALLTLV 771
|
890 900 910
....*....|....*....|....*....|....*....
gi 378977672 759 RMLNPFTPHASFTLWRELNGEGD---IDNAPWPVADESA 794
Cdd:TIGR00392 772 RLLAPFLPHTAEEIYQNLPGGEEeesVHLNLWPEVDEEF 810
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-794 |
6.19e-56 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 207.65 E-value: 6.19e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 1 MQEQYRPEEIESKVQLHWDENRTFEvTEDESKEKYyCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QPi 77
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFK-PDDNSKKPF-SI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwLP- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 78 GWDAFG----------LPAEG------------AAVKNntapapWT---YDNIaymKNQLKMLGFGYDWSRELATCTPEY 132
Cdd:PRK05729 81 GTDHAGiatqmvverqLAAEGksrhdlgrekflEKVWE------WKeesGGTI---TNQLRRLGASCDWSRERFTMDEGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 133 YRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtkvERKEIPQ--WFIKitaYADEllndldkld 210
Cdd:PRK05729 152 SKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV------------EYKEVKGklWHIR---YPLA--------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 211 hwpdtvktmqrnwigrsvgveisfDVNDYadkLTVYTTRPDTFMGCTYLAVaagHPLaqqaaannpalaafiDEcRNTKV 290
Cdd:PRK05729 208 ------------------------DGSDY---LVVATTRPETMLGDTAVAV---NPE---------------DE-RYKHL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 291 AeadmatmekkgvdtGFKAIHPLTGEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLnikPVIlaadgsepdl 370
Cdd:PRK05729 242 I--------------GKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL---PMI---------- 294
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 371 seQALTEKGVLF-NSGEFSGLD-YEAGfNAIADKLAAMGV-------------GER---------------KV------- 413
Cdd:PRK05729 295 --NIMDEDGTINeNPGEYQGLDrFEAR-KAIVADLEELGLlvkiephthsvghSDRsgvviepylsdqwfvKMkplakpa 371
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 414 ------------------NYR-----LRDWGVSRQRYWGAPIPMVTLEDGTVLPTPEDqlpvilPEDVVMDGITspikad 470
Cdd:PRK05729 372 leavengeikfvperwekTYFhwmenIQDWCISRQLWWGHRIPAWYDEDGEVYVGREE------PEAREKALLT------ 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 471 pewakttvngqpalRETDTFDT-FmeSS---------WyyarytcPQyqegmlDSKAANYWLPVDIYIGGieHAIMhlly 540
Cdd:PRK05729 440 --------------QDEDVLDTwF--SSalwpfstlgW-------PE------KTEDLKRFYPTSVLVTG--FDII---- 484
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 541 frFFHklmrDAGMVNS------DEPAKQLLCQGMVladafyyvgengernwvspvdaiveRDEKGRivkakdaaghelvy 614
Cdd:PRK05729 485 --FFW----VARMIMMglhftgQVPFKDVYIHGLV-------------------------RDEQGR-------------- 519
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 615 tgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVW---KLVYEHTTKGEVAAL-N 690
Cdd:PRK05729 520 ----KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEERVEGYRNFANKLWnasRFVLMNLEGADVGELpD 595
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 691 VAALS-EDQKALRRdIHKTIAKVTDDIGRRQtFNTAIAAIMELM-NK-------LAKaPQEDEQDRALMQEALLAV---- 757
Cdd:PRK05729 596 PEELSlADRWILSR-LNRTVAEVTEALDKYR-FDEAARALYEFIwNEfcdwyleLAK-PVLQEAAKRATRATLAYVleqi 672
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 378977672 758 VRMLNPFTPHASFTLWRELNGEGDIDN---APWPVADESA 794
Cdd:PRK05729 673 LRLLHPFMPFITEELWQKLAPLGIEESimlAPWPEADEAI 712
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-795 |
3.38e-53 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 199.89 E-value: 3.38e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYyCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QPi 77
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPF-TI-VIPPPnvTGSLHMGHALNNTLQDILIRYKRMQGYNTLwQP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 78 GWDAFG----------LPAEG------------AAVknntapapW----TYDNIayMKNQLKMLGFGYDWSRELATCTPE 131
Cdd:COG0525 80 GTDHAGiatqavverqLAEEGksrhdlgrekflERV--------WewkeESGGT--ITNQLRRLGASCDWSRERFTMDEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 132 YYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtkvERKEIPQ--WFIKitaY--ADEllndld 207
Cdd:COG0525 150 LSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV------------EHEEVKGhlWHIR---YplADG------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 208 kldhwpdtvktmqrnwigrsvgveisfdvndyADKLTVYTTRPDTFMGCTYLAVaagHPLaqqaaannpalaafiDEcRN 287
Cdd:COG0525 209 --------------------------------SGYIVVATTRPETMLGDTAVAV---HPE---------------DE-RY 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 288 TKVAeadmatmekkgvdtGFKAIHPLTGEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIkPVILAADGSe 367
Cdd:COG0525 238 KHLI--------------GKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM-INILDEDGT- 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 368 pdlseqaLTEKGvlfnsGEFSGLD-YEAGfNAIADKLAAMG-----------VG-------------------------- 409
Cdd:COG0525 302 -------INENA-----GKYRGLDrFEAR-KAIVADLEELGllvkvephkhsVGhsdrsgtviepylsdqwfvkmkplak 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 410 ---------------ERKVN-YR-----LRDWGVSRQRYWGAPIPMVTLEDGTVLptpedqlpvilpedVVMDGITSPIK 468
Cdd:COG0525 369 paieavedgeikfvpERWEKtYFhwmenIRDWCISRQLWWGHRIPAWYCPDGEVY--------------VARTEPEACAK 434
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 469 ADPEwakttvngqpAL-RETDTFDT-FmeSSWyyarytcpqyqegmL----------DSKAANYWLPVDIYIGG--Ieha 534
Cdd:COG0525 435 AGSV----------NLtQDEDVLDTwF--SSA--------------LwpfstlgwpeKTEDLKYFYPTSVLVTGfdI--- 485
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 535 imhlLYF---RffhklMRDAGMVNSDE-PAKQLLCQGMVladafyyvgengernwvspvdaiveRDEKGRivkakdaagh 610
Cdd:COG0525 486 ----IFFwvaR-----MIMMGLHFTGEvPFKDVYIHGLV-------------------------RDEQGR---------- 521
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 611 elvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVW---KLV------YEHT 681
Cdd:COG0525 522 --------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWnasRFVlmnlegFDPG 593
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 682 TKGEVAALNVAA---LSEdqkalrrdIHKTIAKVTDDIGRRQtFNTAIAAIMELM-NK-------LAKAP--QEDEQDRA 748
Cdd:COG0525 594 LDPDPEELSLADrwiLSR--------LNKTIAEVTEALEKYR-FDEAAQALYDFVwNEfcdwyleLAKPRlyGGDEAAKR 664
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....
gi 378977672 749 LMQEALLAV----VRMLNPFTPHASFTLWREL---NGEGDIDNAPWPVADESAM 795
Cdd:COG0525 665 ETRATLVYVleqiLRLLHPFMPFITEEIWQKLpprKEGESIMLAPWPEADEELI 718
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-801 |
6.22e-51 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 193.16 E-value: 6.22e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 48 LHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA--VKNNTAPAPWTY-----------------DNIA-Y 107
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPILGIAerIARGDPETIELYkslygipeeelekfkdpEYIVeY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 108 ----MKNQLKMLGFGYDWSRELATCTPEYyrweQKF----FTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGccwrc 179
Cdd:PRK12300 81 fseeAKEDMKRIGYSIDWRREFTTTDPEY----SKFiewqFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG----- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 180 dtkvERKEIPQW-FIKITAYADELL-------------NDLdkldhW--PDT----VKTMQRNWIgrsvgveISFDVndy 239
Cdd:PRK12300 152 ----EEPEIVEYtLIKFEESEDLILpaatlrpetifgvTNL-----WvnPDAtyvkAEVDGEKWI-------VSKEA--- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 240 ADKLTvyttrpdtfmgctylavaaghplaqqaaannpalaafiDECRNTKVAEadmatmEKKGVD-TGFKAIHPLTGEQI 318
Cdd:PRK12300 213 AEKLS--------------------------------------FQDRDVEIIE------EIKGSElIGKKVKNPVTGKEV 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 319 PVWAANFVLMEYGTGAVMAVPGHDQRDY--------EFASKYGLNIKPVI--------LAAD---------GSEPDLsEQ 373
Cdd:PRK12300 249 PILPADFVDPDNGTGVVMSVPAHAPYDYvalrdlkkNKELLDVIEPIPLIevegygefPAKEvveklgiksQEDPEL-EE 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 374 ALTE-------KGVLF-NSGEFSGLDYEAGFNAIADKLAAMGVG-------ERKV------------------------- 413
Cdd:PRK12300 328 ATKEvyraefhKGVLKeNTGEYAGKPVREAREKITKDLIEKGIAdimyefsNRPVycrcgtecvvkvvkdqwfidysdpe 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 414 -----------------NYR---------LRDWGVSRQRYWGAPIP------MVTLEDGTVLP--------------TPE 447
Cdd:PRK12300 408 wkelahkaldnmeiipeEYRkefentidwLKDRACARRRGLGTRLPwdeewiIESLSDSTIYMayytiahkireygiKPE 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 448 DqlpvILPE--DVVMDGITSPikadPEWAKTTVNGQPALREtdtfdtfMESSWyyarytcpqyqegmldskaaNYWLPVD 525
Cdd:PRK12300 488 Q----LTPEffDYVFLGKGDP----EEVSKKTGIPKEILEE-------MREEF--------------------LYWYPVD 532
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 526 IYIGGIEHAIMHLLYFRFFHKLMRDagmvnsdepaKQLLCQGMVLadafyyvgeNGernWVspvdaIVErdekGRivkak 605
Cdd:PRK12300 533 WRHSGKDLIPNHLTFFIFNHVAIFP----------EEKWPRGIVV---------NG---FV-----LLE----GK----- 576
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 606 daaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVYEHTTKGE 685
Cdd:PRK12300 577 -------------KMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYELAKELIEIGG 643
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 686 VAALNvaalSEDQKALRRdIHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKApQE--DEQDRALMQEALLAVVRMLNP 763
Cdd:PRK12300 644 EEELR----FIDKWLLSR-LNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWY-LRrvGEANNKVLREVLEIWIRLLAP 717
|
890 900 910
....*....|....*....|....*....|....*...
gi 378977672 764 FTPHASFTLWRELNGEGDIDNAPWPVADESAMVEDSTL 801
Cdd:PRK12300 718 FTPHLAEELWHKLGGEGFVSLEKWPEPDESKIDEEAEL 755
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
658-776 |
1.66e-48 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 167.40 E-value: 1.66e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 658 WQESGVEGANRFLKRVWKLVYEHTtKGEVAALNVAALSEDQKALRRDIHKTIAKVTDDIGRRQtFNTAIAAIMELMNKLA 737
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELA-EALAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLR-FNTAIAALMELVNALY 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 378977672 738 KAPQEDEQDRALMQEALLAVVRMLNPFTPHASFTLWREL 776
Cdd:cd07958 79 KYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
42-651 |
1.85e-47 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 173.59 E-value: 1.85e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAP----------------WTYDNI 105
Cdd:cd00817 10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKtrhdlgreeflekcweWKEESG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 106 AYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgcCWRCDTKVER 185
Cdd:cd00817 90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CSRSGDVIEP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 186 KEIPQWFIKITAYADELLndldkldhwpdtvktmqrnwigrsvgveisfdvndyadkltvyttrpdtfmgctylavaagh 265
Cdd:cd00817 166 LLKPQWFVKVKDLAKKAL-------------------------------------------------------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 266 plaqqaaannpalaafidecrntkvaeadmatmekkgvdtgfkaihpltgeqipvwaanfvlmeygtgavmavpghdqrd 345
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 346 yEFASKYGLNIKPvilaadgsepdlseqaltekgvlfnsgEFSGLDYEAGFNAIadklaamgvgerkvnyrlRDWGVSRQ 425
Cdd:cd00817 184 -EAVKEGDIKFVP---------------------------ERMEKRYENWLENI------------------RDWCISRQ 217
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 426 RYWGAPIPMVTLED-GTVLPTPEDQLPVILPEDVVMDGitspiKADPEWAkttvngqpalRETDTFDTFMeSSWYYARYT 504
Cdd:cd00817 218 LWWGHRIPAWYCKDgGHWVVAREEDEAIDKAAPEACVP-----CGGEELK----------QDEDVLDTWF-SSSLWPFST 281
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 505 CPQYQEgmldSKAANYWLPVDIYIGGieHAImhlLYFRFFHKLMRdaGMVNSDE-PAKQLLCQGMVladafyyvgenger 583
Cdd:cd00817 282 LGWPEE----TKDLKKFYPTSLLVTG--HDI---IFFWVARMIMR--GLKLTGKlPFKEVYLHGLV-------------- 336
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378977672 584 nwvspvdaiveRDEKGRivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASP 651
Cdd:cd00817 337 -----------RDEDGR------------------KMSKSLGNVIDPLDVIDGYGADALRFTLASAAT 375
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
4-794 |
3.08e-46 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 179.12 E-value: 3.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 4 QYRPEEIESKVQLHWDENRTFE--VTEDESKEKYYclsmL----PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL-QP 76
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEksREARAGRPKFV----LhdgpPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPyVP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 77 iGWDAFGLPAEGAAVKNN--TAPAPWTYD--------------NIAYMKNQLKMLGFGYDWSRELATCTPEYYR---WEq 137
Cdd:COG0060 91 -GWDCHGLPIELKVEKELgiKKKDIEKVGiaefrekcreyalkYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsiwWA- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 138 kfFTELYKKGLVYKKTSAVNWCPNDQTVLAN-EqvidgccwrcdtkVERKEI--PQWFIKITAYADELLNDLDKLdhwpd 214
Cdd:COG0060 169 --LKKLYEKGLLYKGLKPVPWCPRCGTALAEaE-------------VEYKDVtsPSIYVKFPVKDEKALLLLEDA----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 215 tvktmqrnwigrsvgveisfdvndyadKLTVYTTRPDTfmgctyL----AVAAgHPlaqqaaannpalaaFID----ECR 286
Cdd:COG0060 229 ---------------------------YLVIWTTTPWT------LpanlAVAV-HP--------------DIDyvlvEVT 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 287 NTK---VAEADM-ATMEKKGVDT-------------GFKAIHPLTGEQI-----PVWAANFVLMEYGTGAV-MAvPGHDQ 343
Cdd:COG0060 261 GGErliLAEALVeAVLKELGIEDyevlatfkgaeleGLRYEHPFYYVVGydrahPVILGDYVTTEDGTGIVhTA-PGHGE 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 344 RDYEFASKYGLNI-KPV-----------------ILAADgsePDLSEqALTEKGVLFNSGE------------------- 386
Cdd:COG0060 340 DDFEVGKKYGLPVlNPVdddgrfteeaplfaglfVKDAN---PAIIE-DLKERGALLAREKithsyphcwrcktpliyra 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 387 ----FSGLDyeagfnAIADK-LAAMgvgeRKVNY-------RL-------RDWGVSRQRYWGAPIPMVTLED-GTVLPTP 446
Cdd:COG0060 416 tpqwFISMD------KLRDRaLEAI----EKVNWipewgegRFgnmlenrPDWCISRQRYWGVPIPIWVCEDcGELHRTE 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 447 EdqlpVI--LPEDVVMDGITSPIKAD------PEWAKTTVNGQPALRETDTFDTFMES--SWYyarytcpqyqeGMLDSK 516
Cdd:COG0060 486 E----VIgsVAELLEEEGADAWFELDlhrpflDETLKCPKCGGTMRRVPDVLDVWFDSgsMHF-----------AVLENR 550
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 517 AANYWlPVDIYIGGI-EHaimhllyfR-FFHKLMRDAGMVNSDEPAKQLLCQGMVLadafyyvgengernwvspvdaive 594
Cdd:COG0060 551 EELHF-PADFYLEGSdQT--------RgWFYSSLLTSTALFGRAPYKNVLTHGFVL------------------------ 597
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 595 rDEKGRivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMFASP-ADMTLEWQesGVEGANRFLKRV 673
Cdd:COG0060 598 -DEDGR------------------KMSKSLGNVVDPQEVIDKYGADILRLWVASSDYwGDLRFSDE--ILKEVRDVYRRL 656
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 674 WklvyeHTT----------KGEVAALNVAALSE-DQKALRRdIHKTIAKVTDDIGRRQtFNTAIAAIMELMN-------- 734
Cdd:COG0060 657 R-----NTYrfllanlddfDPAEDAVPYEDLPElDRWILSR-LNELIKEVTEAYDNYD-FHRAYRALHNFCVedlsnwyl 729
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 735 KLAK----APQEDEQDRALMQ----EALLAVVRMLNPFTPHASFTLWRELNGEGD--IDNAPWPVADESA 794
Cdd:COG0060 730 DISKdrlyTEAADSLDRRAAQttlyEVLETLVRLLAPILPFTAEEIWQNLPGEAEesVHLADWPEVDEEL 799
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
5-776 |
3.92e-36 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 147.83 E-value: 3.92e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 5 YRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLsMLPYP--SGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAF 82
Cdd:PRK14900 19 YEHREVEARWYPFWQERGYFHGDEHDRTRPPFSI-VLPPPnvTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 83 GLP-----------AEGAAVKNNTAPA------PWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYK 145
Cdd:PRK14900 98 GIAtqmivekelkkTEKKSRHDLGREAflervwAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 146 KGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEipqwfikitAYADELlndldkldhwpdtvktmqrnWig 225
Cdd:PRK14900 178 EGLIYREKKLINWCPDCRTALS------------DLEVEHEE---------AHQGEL--------------------W-- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 226 rsvgvEISFDVNDYADKLTVYTTRPDTFMGCTYLAVaagHPLAqqaaannpalaafidecrntkvaeadmatmEKKGVDT 305
Cdd:PRK14900 215 -----SFAYPLADGSGEIVVATTRPETMLGDTAVAV---HPLD------------------------------PRYMALH 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 306 GFKAIHPLTGEQIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVIlaadGSEPDLSEQAltekgvlfns 384
Cdd:PRK14900 257 GKKVRHPITGRTFPIVAdAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVI----GPDGRMTAEA---------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 385 GEFSGLD-YEAGFNAIADkLAAMGVGERKVNYRL---------------------------------------------- 417
Cdd:PRK14900 323 GPLAGLDrFEARKEVKRL-LAEQGLDRGAKPHVLplgrcqrsatilepllsdqwyvrieplarpaieaveqgrtrfipeq 401
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 418 ------------RDWGVSRQRYWGAPIPMVTLEDGTVLPTPEDqlpvilpedvvmdgitspikadPEwAKTTVNGQPALR 485
Cdd:PRK14900 402 wtntymawmrniHDWCISRQLWWGHQIPAWYCPDGHVTVARET----------------------PE-ACSTCGKAELRQ 458
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 486 ETDTFDTFMESS-WYYARYTCPQyqegmlDSKAANYWLPVDIYIGGiehaimHLLYFRFFHKLMRDAGMVNSDEPAKQLL 564
Cdd:PRK14900 459 DEDVLDTWFSSGlWPFSTMGWPE------QTDTLRTFYPTSVMETG------HDIIFFWVARMMMMGLHFMGEVPFRTVY 526
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 565 CQGMVladafyyvgengernwvspvdaiveRDEKGRivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRL 644
Cdd:PRK14900 527 LHPMV-------------------------RDEKGQ------------------KMSKTKGNVIDPLVITEQYGADALRF 563
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 645 FMMFASPADMTLEWQESGVEGANRFLKRVWklvyehtTKGEVAALNVAALSEDQKALRRD---------IHKTIAKVTDD 715
Cdd:PRK14900 564 TLAALTAQGRDIKLAKERIEGYRAFANKLW-------NASRFALMNLSGYQERGEDPARLartpadrwiLARLQRAVNET 636
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378977672 716 IGRRQT--FNTAIAAIMELM--------NKLAKA------PQEDEQDRALMQEALLAVVRMLNPFTPHASFTLWREL 776
Cdd:PRK14900 637 VEALEAfrFNDAANAVYAFVwhelcdwyIELAKEalasedPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVL 713
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-449 |
2.74e-33 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 138.60 E-value: 2.74e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDE----SKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQP 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAkslnSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 77 IGWDAFGLpAEGAAV------KNNtaPAPWTYDNIAYMK--------------NQLKMLGFGYDWSRELATCTPEYYRWE 136
Cdd:PTZ00419 104 PGTDHAGI-ATQVVVekklmkEEN--KTRHDLGREEFLKkvwewkdkhgnnicNQLRRLGSSLDWSREVFTMDEQRSKAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 137 QKFFTELYKKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcDTKVERKEIPQ-WFIKITAYadellndlDKldhwpdT 215
Cdd:PTZ00419 181 KEAFVRLYEDGLIYRDTRLVNWCCYLKTAIS------------DIEVEFEEIEKpTKITIPGY--------DK------K 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 216 VKtmqrnwigrsVGV--EISFDVNDYAD-KLTVYTTRPDTFMGCTYLAVaagHPLaqqaaannpalaafiDEcRNTKVae 292
Cdd:PTZ00419 235 VE----------VGVlwHFAYPLEDSGQeEIVVATTRIETMLGDVAVAV---HPK---------------DE-RYKKL-- 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 293 admatmekkgvdTGFKAIHPLT-GEQIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKpVILAADGSepdl 370
Cdd:PTZ00419 284 ------------HGKELIHPFIpDRKIPIIAdDELVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFI-NIFTLDGK---- 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 371 seqaLTEkgvlfNSGEFSGLD-YEAGFnAIADKLAAMGVGERK----------------VNYRL---------------- 417
Cdd:PTZ00419 347 ----INE-----NGGEFAGMHrFDCRR-KIEEELKEMGLLRDKvpnpmrlprcsrsgdiVEPMLipqwyvnckdmakrav 416
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 418 --------------------------RDWGVSRQRYWGAPIP--MVTLEDGTVLPTPEDQ 449
Cdd:PTZ00419 417 eavrngelkiipsshenvwyhwleniQDWCISRQLWWGHRIPayRVISKGPETDPSDEEP 476
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
34-224 |
3.79e-33 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 130.23 E-value: 3.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAA-------------VKNNTAPAPW 100
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 101 TYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKktsavnwcpndqtvlaneqvidgccwrcD 180
Cdd:cd00668 81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYR----------------------------G 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 378977672 181 TKVERKEiPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWI 224
Cdd:cd00668 133 THPVRIT-EQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWL 175
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
34-246 |
3.08e-29 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 119.17 E-value: 3.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 34 KYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:cd00814 1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 114 MLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLAneqvidgccwrcdtkvERKEIPQWF 192
Cdd:cd00814 81 WLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP----------------EWREEEHYF 141
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378977672 193 IKITAYADELLNDLDKLDH--WPDTVKTMQRNWIG-----RSV-------GVEISFDvndyaDKLTVY 246
Cdd:cd00814 142 FRLSKFQDRLLEWLEKNPDfiWPENARNEVLSWLKeglkdLSItrdlfdwGIPVPLD-----PGKVIY 204
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
33-246 |
1.54e-28 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 120.99 E-value: 1.54e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 33 EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQL 112
Cdd:COG0143 1 KKFLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEFKELF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 113 KMLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQT--------------------------- 164
Cdd:COG0143 81 EKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERflpdryvegtcpkcgaedaygdqcenc 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 165 --VLANEQVIDGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWI--G---RSV------GVE 231
Cdd:COG0143 158 gaTLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENPDIQPEVRNEVLSWLkeGlqdLSIsrdfdwGIP 237
|
250
....*....|....*
gi 378977672 232 ISFDvndyaDKLTVY 246
Cdd:COG0143 238 VPGD-----PGKVFY 247
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-644 |
2.52e-28 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 122.57 E-value: 2.52e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 11 ESKVQLHWDENRTFE-VTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAE-- 87
Cdd:PLN02843 9 EPEIQKLWEENQVYKrVSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIElk 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 88 -----GAAVKNNTAP-------APWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSA 155
Cdd:PLN02843 89 vlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 156 VNWCPNDQTVLANEQVidgccwrcdtkverkEIPQWFIKITAYA---------------DELLNDLdKLDHWPDTVKTMQ 220
Cdd:PLN02843 169 VHWSPSSRTALAEAEL---------------EYPEGHVSKSIYVafpvvspsetspeelEEFLPGL-SLAIWTTTPWTMP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 221 RNwigrsvgveISFDVNdyaDKLtvyttrpdtfmgcTYLAVAAGHPLAQQAAANNPALAAFIDECRNTK-----VAEADM 295
Cdd:PLN02843 233 AN---------AAVAVN---DKL-------------QYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQQklfliVATDLV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 296 ATMEKK------------GVD-TGFKAIHPLTGEQIPVWAA-NFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNI-KPV- 359
Cdd:PLN02843 288 PALEAKwgvklvvlktfpGSDlEGCRYIHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLlSPVd 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 360 ------ILAADGSEPD-LSE------QALTEKGVL---------------------FNSGE--FSGLDyeaGFNAIAdkL 403
Cdd:PLN02843 368 dagkftEEAGQFSGLSvLGEgnaavvEALDEAGSLlmeeayghkypydwrtkkptiFRATEqwFASVE---GFRQAA--L 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 404 AAMgvgeRKVNY-------RLR-------DWGVSRQRYWGAPIPMVTLEDgtvlpTPEdqlpVILPEDVVmDGITSPIK- 468
Cdd:PLN02843 443 DAI----DKVKWipaqgenRIRamvsgrsDWCISRQRTWGVPIPVFYHVE-----TKE----PLMNEETI-AHVKSIVAq 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 469 --ADPEWAKTTVNGQPA---------LRETDTFDTFMES--SWyyarytcpqyqEGMLDSKAANYWlPVDIYIGGIEHai 535
Cdd:PLN02843 509 kgSDAWWYMDVEDLLPEkyrdkasdyEKGTDTMDVWFDSgsSW-----------AGVLGSREGLSY-PADLYLEGSDQ-- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 536 mHLLYFRffHKLMRDAGmVNSDEPAKQLLCQGMVLadafyyvgengernwvspvdaiverDEKGRivkakdaaghelvyt 615
Cdd:PLN02843 575 -HRGWFQ--SSLLTSVA-TKGKAPYKSVLTHGFVL-------------------------DEKGF--------------- 610
|
730 740 750
....*....|....*....|....*....|....*...
gi 378977672 616 gmsKMSKSKNNGIDPQVMVE---------RYGADTVRL 644
Cdd:PLN02843 611 ---KMSKSLGNVVDPRLVIEggknqkqepAYGADVLRL 645
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
35-224 |
3.12e-28 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 117.78 E-value: 3.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 35 YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKM 114
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 115 LGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC------------------ 175
Cdd:pfam09334 81 FNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEGTCphcgsedargdqcencgr 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 378977672 176 -----------CWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDH-WPDTVKTMQRNWI 224
Cdd:pfam09334 158 hleptelinpkCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPeWPENVKNMVLEWL 218
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
33-204 |
1.55e-25 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 111.51 E-value: 1.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 33 EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQL 112
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 113 KMLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDG--CCWRCDTKVERKEIP 189
Cdd:PRK11893 81 EALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDgyRCPPTGAPVEWVEEE 157
|
170
....*....|....*
gi 378977672 190 QWFIKITAYADELLN 204
Cdd:PRK11893 158 SYFFRLSKYQDKLLE 172
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-788 |
3.98e-25 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 112.34 E-value: 3.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 11 ESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFG------- 83
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqlvv 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 84 ---LPAEGAAVKNNTAPA------PWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTS 154
Cdd:PLN02943 146 ekmLASEGIKRTDLGRDEftkrvwEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 155 AVNWCPNDQTVLAneqvidgccwrcDTKVErkeipqwfikitaYADEllndldkldhwPDTVKTMQRNWIGRSvgveisf 234
Cdd:PLN02943 226 MVNWSPNLQTAVS------------DLEVE-------------YSEE-----------PGTLYYIKYRVAGGS------- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 235 dvNDYadkLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpalaafiDECRNTKVaeadmatmekkgvdTGFKAIHPLT 314
Cdd:PLN02943 263 --EDF---LTIATTRPETLFGDVAIAV---NP----------------EDDRYSKY--------------IGKMAIVPMT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 315 -GEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPViLAADGS----------------EPDLSEQALTE 377
Cdd:PLN02943 305 yGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNV-MNKDGTlnevaglywfeareklWSDLEETGLAV 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 378 KGVLFN--------SGE----FSGLDYEAGFNAIADK-LAAMGVGERKV---------NYRL---RDWGVSRQRYWGAPI 432
Cdd:PLN02943 384 KKEPHTlrvprsqrGGEviepLVSKQWFVTMEPLAEKaLKAVENGELTIiperfekiyNHWLsniKDWCISRQLWWGHRI 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 433 PMVTL------EDGTVLPTPEDQLPvilpedvvmdgitspiKADPEWAKTTVNGQpalrETDTFDTFMESS-WYYARYTC 505
Cdd:PLN02943 464 PVWYIvgkdceEDYIVARSAEEALE----------------KAREKYGKDVEIYQ----DPDVLDTWFSSAlWPFSTLGW 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 506 PQyqegmLDSKAANYWLPVDIYIGGieHAIMHLLYFRFFHKLMRDAGMVnsdePAKQLLCQGMVladafyyvgengernw 585
Cdd:PLN02943 524 PD-----VSAEDFKKFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHGLI---------------- 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 586 vspvdaiveRDEKGRivkakdaaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRlFMMFASPADMTLEWQESGVEG 665
Cdd:PLN02943 577 ---------RDSQGR------------------KMSKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTS 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 666 ANRFLKRVW---KLVYEH-TTKGEVAAL-NVAALSEDQKA-----------LRRDIHKTIAKVTDDIGR-------RQTF 722
Cdd:PLN02943 629 NKAFTNKLWnagKFVLQNlPSQSDTSAWeHILACKFDKEEsllslplpecwVVSKLHELIDSVTTSYDKyffgdvgREIY 708
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378977672 723 NTAIAAIMELMNKLAKA---PQEDEQDRALMQEALLAV----VRMLNPFTPHASFTLWRELNGEGD-IDNAPWP 788
Cdd:PLN02943 709 DFFWSDFADWYIEASKTrlyHSGDNSALSRAQAVLLYVfeniLKLLHPFMPFVTEELWQALPYRKEaLIVSPWP 782
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
42-224 |
1.22e-21 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 97.30 E-value: 1.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNI--------------AY 107
Cdd:cd00818 10 PYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMgiaefnakcrefalRY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 108 ---MKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWcPndqtvlaneqVIdgccwrcdtkve 184
Cdd:cd00818 90 vdeQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P----------LI------------ 146
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 378977672 185 RKEIPQWFIKITAYADELLNDLDKLdHW-PDTVKTMQRNWI 224
Cdd:cd00818 147 YRATPQWFIRVTKIKDRLLEANDKV-NWiPEWVKNRFGNWL 186
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-439 |
8.84e-19 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 91.88 E-value: 8.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 1 MQEQYRPEEIESKVQLHWDENRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 81 AFGLPAEGAAVKNNTAPAPWTYDNIAYMK-----------------NQLKMLGFGYDWSRELATCTPEYYRWEQKFFTEL 143
Cdd:PLN02381 176 HAGIATQVVVEKKLMRERHLTRHDIGREEfvsevwkwkdeyggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 144 YKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdTKVERKEipQWFIKITAYAdellndldkldhwpdtvKTMQrnw 223
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEV---------DYIDIKE--RTLLKVPGYD-----------------KPVE--- 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 224 igrsVGVEISF--DVNDYADKLTVYTTRPDTFMGCTYLAVaagHPlaqqaaannpalaafiDECRNTKVAeadmatmekk 301
Cdd:PLN02381 305 ----FGVLTSFayPLEGGLGEIVVATTRIETMLGDTAIAI---HP----------------DDERYKHLH---------- 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 302 gvdtGFKAIHPLTGEQIPVWA-ANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKpVILAADGSEPDLS--------- 371
Cdd:PLN02381 352 ----GKFAVHPFNGRKLPIICdAILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFI-NIFTDDGKINSNGgsefagmpr 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 372 -------EQALTEKGV-----------------------------LFNSGEFSGLDYEAGFNAIADKLAAMGVGERKVNY 415
Cdd:PLN02381 427 faareavIEALQKKGLyrgaknnemrlglcsrtndvvepmikpqwFVNCSSMAKQALDAAIDGENKKLEFIPKQYLAEWK 506
|
490 500 510
....*....|....*....|....*....|
gi 378977672 416 R----LRDWGVSRQRYWGAPIPM--VTLED 439
Cdd:PLN02381 507 RwlenIRDWCISRQLWWGHRIPAwyVTLED 536
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
41-224 |
1.65e-18 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 90.60 E-value: 1.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 41 LPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPApwtyDNIAYMKNQ----LKMLG 116
Cdd:PRK00133 10 LPYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPE----ELIARYHAEhkrdFAGFG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 117 FGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVL-------------ANEQVIDGC--CWR-- 178
Cdd:PRK00133 86 ISFDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLpdrfvkgtcpkcgAEDQYGDNCevCGAty 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 378977672 179 ------------CDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWI 224
Cdd:PRK00133 163 sptelinpksaiSGATPVLKESEHFFFKLPRFEEFLKEWITRSGELQPNVANKMKEWL 220
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
619-790 |
2.30e-18 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 89.40 E-value: 2.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFASP--ADMTLEWQE------SgvEGANR---FLKRVWKLVYEHtTKGEVA 687
Cdd:COG0143 327 KMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPfgQDGDFSWEDfvarvnS--DLANDlgnLASRTLSMIHKY-FDGKVP 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 688 AlnVAALSEDQKALRRDIHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNK---------LAKAPQEDEQDRALMQ--EA 753
Cdd:COG0143 404 E--PGELTEADEELLAEAEAALEEVAEAMEAFE-FRKALEEIMALaraANKyidetapwkLAKDEDPERLATVLYTllEA 480
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 378977672 754 LLAVVRMLNPFTPHASFTLWRELNGEGD---IDNAPWPVA 790
Cdd:COG0143 481 LRILAILLKPFLPETAEKILEQLGLEGDeltWEDAGWPLP 520
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
7-670 |
2.59e-17 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 87.09 E-value: 2.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 7 PEEiESKVQLHWDENRTFE--VTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:PLN02882 11 PKQ-EEKILSLWSEIDAFKtqLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 85 PAEGAAVKNNtapapwtydNIAYMKNQLKMlGFG-YD---------WSRELATCTPEYYRW----------EQKF----- 139
Cdd:PLN02882 90 PVEYEIDKKL---------GIKRRDDVLKM-GIDkYNeecrsivtrYSKEWEKTVTRTGRWidfendyktmDPKFmesvw 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 140 --FTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtKVERKEIPqwfikitayadellndldkldhwpdtvk 217
Cdd:PLN02882 160 wvFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEA----------GLNYKDVS---------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 218 tmqrnwigrSVGVEISFDVNDYADK--LTVYTTRPDTFMGCTYLAVaagHP-LAQQAAANNPALAAFI-DECR------- 286
Cdd:PLN02882 202 ---------DPAVMVSFPIVGDPDNasFVAWTTTPWTLPSNLALCV---NPnFTYVKVRNKYTGKVYIvAESRlsalpta 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 287 ---NTKVAEADMAT-----MEK-KGVDTGFKAIHPL-------TGEQIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFAS 350
Cdd:PLN02882 270 kpkSKKGSKPENAAegyevLAKvPGSSLVGKKYEPLfdyfsefSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCL 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 351 KYGLNIK----PVILAADG----------------SEPDLSEqALTEKGVLFNSGEF-----------SGLDYEA----- 394
Cdd:PLN02882 350 ANGIIEKggnlPVPVDDDGcftekvtdfsgryvkdADKDIIA-AIKAKGRLVKSGSIthsypfcwrsdTPLIYRAvpswf 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 395 -GFNAIADKLAAMG---------VGERKVNYRL---RDWGVSRQRYWGAPIPMVTLEDG--TVLPTPEDQLPVILPEDV- 458
Cdd:PLN02882 429 vKVEEIKDRLLENNkqtywvpdyVKEKRFHNWLenaRDWAVSRSRFWGTPLPIWISDDGeeVVVIGSIAELEKLSGVKVt 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 459 -----VMDGITSPIKADPEwakttvngQPALRET-DTFDTFMES-SWYYARYTCPQYQEGMLDSKaanywLPVDIYIGGI 531
Cdd:PLN02882 509 dlhrhFIDHITIPSSRGPE--------FGVLRRVdDVFDCWFESgSMPYAYIHYPFENKELFEKN-----FPADFVAEGL 575
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 532 EHAimhllyfR-FFHKLmrdagMVNS----DEPA-KQLLCQGMVLAdafyyvgENGErnwvspvdaiverdekgrivkak 605
Cdd:PLN02882 576 DQT-------RgWFYTL-----MVLStalfDKPAfKNLICNGLVLA-------EDGK----------------------- 613
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 378977672 606 daaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMMfASP---ADmTLEWQESGVEG-----------ANRFL 670
Cdd:PLN02882 614 -------------KMSKSLKNYPDPNEVIDKYGADALRLYLI-NSPvvrAE-PLRFKEEGVFGvvkdvflpwynAYRFL 677
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
697-823 |
1.07e-16 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 77.44 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 697 DQKALRRdIHKTIAKVTDDIGRRQtFNTAIAAIMELM-NKLAK-----------APQEDEQDRALMQEALLAVVRMLNPF 764
Cdd:pfam08264 1 DRWILSR-LNKLIKEVTEAYENYR-FNTAAQALYEFFwNDLSDwylelikdrlyGEEPDSRAQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378977672 765 TPHASFTLWRELngegDIDNAPWPVADESAMVE-----DSTLVVVQVNGKVRGKITVAVDATEE 823
Cdd:pfam08264 79 MPFITEELWQKE----SIHLAPWPEDAELEEAEleeafELRQEIVQAIRKLRSELKIKKSLPLE 138
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
30-203 |
2.39e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 80.23 E-value: 2.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 30 ESKEKYYCLSMLPYPSGRLHMGHVrnYT--IGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTyDNIAY 107
Cdd:PRK12267 1 MMKKTFYITTPIYYPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYV-DEISA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 108 M-KNQLKMLGFGYDwsRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC-CWRCDTKVER 185
Cdd:PRK12267 78 GfKELWKKLDISYD--KFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDGGkCPDCGREVEL 155
|
170
....*....|....*...
gi 378977672 186 KEIPQWFIKITAYADELL 203
Cdd:PRK12267 156 VKEESYFFRMSKYQDRLL 173
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
619-782 |
1.12e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 77.61 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 619 KMSKSKNNGIDPQVMVERYGADTVRLFMM----FASPADMTLE----WQESgvEGANRF---LKRVWKLVYeHTTKGEVA 687
Cdd:PRK11893 299 KMSKSLGNVIDPFDLVDEYGVDAVRYFLLreipFGQDGDFSREafinRINA--DLANDLgnlAQRTLSMIA-KNFDGKVP 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 688 alNVAALSEDQKALRRDIHKTIAKVTDDIGRRQtFNTAIAAIMELMN------------KLAKA-PQEDEQDRALMQEAL 754
Cdd:PRK11893 376 --EPGALTEADEALLEAAAALLERVRAAMDNLA-FDKALEAILALVRaankyideqapwSLAKTdPERLATVLYTLLEVL 452
|
170 180
....*....|....*....|....*...
gi 378977672 755 LAVVRMLNPFTPHASFTLWRELNGEGDI 782
Cdd:PRK11893 453 RGIAVLLQPVMPELAAKILDQLGVEEDE 480
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
619-784 |
2.02e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 74.07 E-value: 2.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 619 KMSKSKNNGIDPQVMVERYGADTVRLFMM----FASPADMTlewQESGVE----------G--ANRFLKRVWKlvYEhtt 682
Cdd:PRK12267 299 KMSKSKGNVVDPEELVDRYGLDALRYYLLrevpFGSDGDFS---PEALVErinsdlandlGnlLNRTVAMINK--YF--- 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 683 KGEVAAlnVAALSEDQKALRRDIHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNK---------LAKAPQEDEQDRALM 750
Cdd:PRK12267 371 DGEIPA--PGNVTEFDEELIALAEETLKNYEELMEELQ-FSRALEEVWKLisrANKyidetapwvLAKDEGKKERLATVM 447
|
170 180 190
....*....|....*....|....*....|....*..
gi 378977672 751 Q---EALLAVVRMLNPFTPHASFTLWRELNGEGDIDN 784
Cdd:PRK12267 448 YhlaESLRKVAVLLSPFMPETSKKIFEQLGLEEELTS 484
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
9-92 |
4.83e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 63.55 E-value: 4.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 9 EIESKVQLHWDENRTFEV--TEDESK--EKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGL 84
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAeaGDEPPKpgEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGM 96
|
....*...
gi 378977672 85 PAEGAAVK 92
Cdd:PLN02959 97 PIKASADK 104
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
619-762 |
5.35e-09 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 59.35 E-value: 5.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 619 KMSKSKNNGIDPQVMVERYGADTVRLFMMFA---SPadmtLEWQESGVEGANRFLKRvwklVYEhttkgevAALNVAALS 695
Cdd:COG0215 265 KMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyrSP----LDFSEEALEEAEKALER----LYN-------ALRRLEEAL 329
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 378977672 696 EDQKALRRDIHKTIAKVT----DDigrrqtFNT--AIAAIMELMNKLAKAPQEDEQDRALmqEALLAVVRMLN 762
Cdd:COG0215 330 GAADSSAEEIEELREEFIaamdDD------FNTpeALAVLFELVREINKALDEGEDKAAL--AALAALLRALG 394
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
9-663 |
1.14e-08 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 59.21 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 9 EIESKVQLHWDENRTFEVTEDESKEK--YYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPA 86
Cdd:PTZ00427 76 EEEEKVLKYWKSIDAFNTSNKLAKNKkaYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 87 EGAAVKNNtapapwtydNIAYMKNQLKMlgfGYD------------WSRELATCTPEYYRW----------EQKF----- 139
Cdd:PTZ00427 156 EYEIEKEN---------NINKKEDILKM---GIDvynekcrgivlkYSNEWVKTVERIGRWidfkndyktmDKTFmesvw 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 140 --FTELYKKGLVYKKTSAVNWCPNDQTVLANEQVidgccwrcdtKVERKEIPQWFIKITAYadeLLNDLDKLDH---WPD 214
Cdd:PTZ00427 224 wvFSELYKNNYVYKSFKVMPYSCKCNTPISNFEL----------NLNYKDTPDPSIIISFV---LCSDFPKVEEecnIEE 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 215 TVKTM-----------QRNWIGrsvGVEISFDVNDYA--DKLTVYTTRPDTFMgcTYLAVAAGHPLAQQAAANNPALAAF 281
Cdd:PTZ00427 291 DKQLLgekysvlynnkRENSNN---GNNNSTNNVCYAqhSEILAWTTTPWTLP--SNLALCVNEHFTYLRIHHVKSNRVV 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 282 I-DECR-------------NTKVAE----ADMATMEKKGVDTGFKAIHPLTGEQIPVWAANFVLMEYGTGAVMAVPGHDQ 343
Cdd:PTZ00427 366 IvGECRlewimkelkwnveDLKIVNrfkgKELKGLRYKPLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGE 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 344 RDYEFASKYGL-----NIKPVILAADG---SEPDL------------------SEQALTEKGVLFNSGEF-----SGLDY 392
Cdd:PTZ00427 446 DDFRVCKKNGVidpekNIFIDPLDANGyftNEVEEvqnlyikeadnvikkklkNENRLLSNNTIVHSYPFcwrsdTPLIY 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 393 E---AGFNAIADKLAAM------------GVGERKVNYRL---RDWGVSRQRYWGAPIPMVTLEDGTVLPTPE-----DQ 449
Cdd:PTZ00427 526 RaipAWFIRVSNSTNELvknnettywipaHIKEKKFHNWIkdaKDWCISRNRYWGTPIPIWADEKMETVICVEsikhlEE 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 450 LPVILPEDVVMDGITSPIKADPEWAKTtvngQPAL-RETDTFDTFMES-SWYYARYTCPqyqegmLDSKAANYW--LPVD 525
Cdd:PTZ00427 606 LSGVKNINDLHRHFIDHIEIKNPKGKT----YPKLkRIPEVFDCWFESgSMPYAKVHYP------FSTEKEDFHkiFPAD 675
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 526 IYIGGIEHAimhllyFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADafyyvgengernwvspvdaiverDEKgrivkak 605
Cdd:PTZ00427 676 FIAEGLDQT------RGWFYTLLVISTLLFDKAPFKNLICNGLVLAS-----------------------DGK------- 719
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 606 daaghelvytgmsKMSKSKNNGIDPQVMVERYGADTVRLFMM--FASPADmTLEWQESGV 663
Cdd:PTZ00427 720 -------------KMSKRLKNYPDPLYILDKYGADSLRLYLInsVAVRAE-NLKFQEKGV 765
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
25-202 |
1.18e-06 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 52.02 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 25 EVTEDESkEKYYCLSMLPYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPaPWTYDN 104
Cdd:PLN02224 62 ESTVDEA-DTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNP-PEHCDI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 105 IAYMKNQL-KMLGFGYDwsRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCwrCDTK- 182
Cdd:PLN02224 140 ISQSYRTLwKDLDIAYD--KFIRTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNC--CPVHq 215
|
170 180
....*....|....*....|...
gi 378977672 183 ---VERKEiPQWFIKITAYADEL 202
Cdd:PLN02224 216 mpcVARKE-DNYFFALSKYQKPL 237
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
660-776 |
1.11e-04 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 42.93 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 660 ESGVEGANRFLKRVW---KLVYEHTTKGEVAALNVAALSEDQKALRRDIHKTIAKVTDDIGRRQtFNTAIAAI------- 729
Cdd:cd07962 3 EKRVEGGRNFCNKLWnaaRFVLMNLEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYR-FSEAATALyeffwnd 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 378977672 730 -----MELMNKLAKAPQEDEQD--RALMQEALLAVVRMLNPFTPHASFTLWREL 776
Cdd:cd07962 82 fcdwyLELVKPRLYGEDEEEKKaaRATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
690-776 |
3.72e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 41.32 E-value: 3.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 690 NVAALSEDQKALRRDIHKTIAKVTDDIGRRQtFNTAIAAIMEL---MNK---------LAKAPQEDEQDRALMQ--EALL 755
Cdd:cd07957 30 EFGGLTEEDEELLEEAEELLEEVAEAMEELE-FRKALEEIMELaraANKyidetapwkLAKEEDPERLATVLYVllELLR 108
|
90 100
....*....|....*....|.
gi 378977672 756 AVVRMLNPFTPHASFTLWREL 776
Cdd:cd07957 109 ILAILLSPFMPETAEKILDQL 129
|
|
| argS |
TIGR00456 |
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed ... |
42-74 |
5.02e-04 |
|
arginyl-tRNA synthetase; This model recognizes arginyl-tRNA synthetase in every completed genome to date. An interesting feature of the alignment of all arginyl-tRNA synthetases is a fairly deep split between two families. One family includes archaeal, eukaryotic and organellar, spirochete, E. coli, and Synechocystis sp. The second, sharing a deletion of about 25 residues in the central region relative to the first, includes Bacillus subtilis, Aquifex aeolicus, the Mycoplasmas and Mycobacteria, and the Gram-negative bacterium Helicobacter pylori. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273085 [Multi-domain] Cd Length: 563 Bit Score: 43.48 E-value: 5.02e-04
10 20 30
....*....|....*....|....*....|...
gi 378977672 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL 74
Cdd:TIGR00456 121 ANPAGPLHVGHLRNAIIGDSLARILEFLGYDVI 153
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
619-764 |
5.69e-04 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 43.48 E-value: 5.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 619 KMSKSKNNGIDPQVMVERYGADTVR-LFMMfaSPADMTLEWQESGVEGA-------NRFLKRVWKLVYEHTTKgevaalN 690
Cdd:PTZ00399 315 KMSKSLKNFITIRQALSKYTARQIRlLFLL--HKWDKPMNYSDESMDEAiekdkvfFNFFANVKIKLRESELT------S 386
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378977672 691 VAALSEDQKALRRDIHKTIAKVTDDIgrRQTFNT--AIAAIMELMNKLAKAPQEDEQDRA-LMQEALLAVVRMLNPF 764
Cdd:PTZ00399 387 PQKWTQHDFELNELFEETKSAVHAAL--LDNFDTpeALQALQKLISATNTYLNSGEQPSApLLRSVAQYVTKILSIF 461
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
758-801 |
7.58e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 43.13 E-value: 7.58e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 378977672 758 VRMLNPFTPHASFTLWRELNG-EGDIDNAPWPVADEsamvEDSTL 801
Cdd:PLN02959 859 TRLITPICPHYAEHVWREILKkEGFAVTAGWPVAGE----PDLTL 899
|
|
| ArgRS_core |
cd00671 |
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic ... |
42-74 |
8.30e-04 |
|
catalytic core domain of arginyl-tRNA synthetases; Arginyl tRNA synthetase (ArgRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. There are at least three subgroups of ArgRS. One type contains both characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. The second subtype lacks the KMSKS motif; however, it has a lysine N-terminal to the HIGH motif, which serves as the functional counterpart to the second lysine of the KMSKS motif. A third group, which is found primarily in archaea and a few bacteria, lacks both the KMSKS motif and the HIGH loop lysine.
Pssm-ID: 185675 [Multi-domain] Cd Length: 212 Bit Score: 41.78 E-value: 8.30e-04
10 20 30
....*....|....*....|....*....|...
gi 378977672 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVL 74
Cdd:cd00671 9 ANPTGPLHVGHLRNAIIGDSLARILEFLGYDVT 41
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
660-765 |
9.20e-04 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 39.80 E-value: 9.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 660 ESGVEGANRFLKRVWKLV-YEHTTKG-EVAALNVAALSEDQKALRRDIHKTIAKVTDDIgRRQTFNTAIAAIMELMNKL- 736
Cdd:cd07375 1 EERLKQARAFLNRLYRLLsFFRKALGgTQPKWDNELLEEADRELLARLQEFIKRTTNAL-EALDPTTAVQELFKFTNELn 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 378977672 737 ---------AKAPQEDEQDRALMQEALLAVVRMLNPFT 765
Cdd:cd07375 80 wyldelkpaLQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
658-776 |
1.80e-03 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 39.11 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 658 WQESGVEGANRFLKRVWKLVYEHTTKGEvaalNVAALSEDQKALRRDIHKTIAKVTDDIGRRQTFNTAIAAIMELMNKLA 737
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEG----ELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLD 76
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 378977672 738 KAPQ--EDEQDRALMQEALLAVVRMLNPFTPHASFTLWREL 776
Cdd:cd07959 77 WYRErgGAGMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
39-175 |
2.05e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 41.69 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 39 SMLPYPSGRLHMGHVrnytIG-----DVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK 113
Cdd:PLN02610 23 SALPYVNNVPHLGNI----IGcvlsaDVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDKYHAIHKEVYD 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 378977672 114 MLGFGYD-WSRelaTCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGC 175
Cdd:PLN02610 99 WFDISFDkFGR---TSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLVEGTC 158
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
705-802 |
3.62e-03 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 39.46 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 705 IHKTIAKVTDDIGRRQtFNTAIAAIMELMNKL-----------AKAPQEDEQDRALMQ---EALLAVVRMLNPFTPHASF 770
Cdd:cd07961 56 LNSLIKEVTEEMEAYD-LYTAVRALLEFIDELtnwyirrnrkrFWGEEGDDDKLAAYAtlyEVLLTLSRLMAPFTPFITE 134
|
90 100 110
....*....|....*....|....*....|....*..
gi 378977672 771 TLWRELNGEGDIDN-----APWPVADESAMveDSTLV 802
Cdd:cd07961 135 EIYQNLRRELGDAPesvhlLDWPEVDESLI--DEELE 169
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
42-127 |
7.56e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 37.84 E-value: 7.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378977672 42 PYPSGRLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLK-MLGFGYD 120
Cdd:cd00802 6 ITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKEDVEyMFLQAAD 85
|
....*..
gi 378977672 121 WSRELAT 127
Cdd:cd00802 86 FLLLYET 92
|
|
| |
