NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1181491981|ref|YP_009353875|]
View 

NADH dehydrogenase subunit 2 (mitochondrion) [Tropidomya abbreviata]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND2 super family cl33357
NADH dehydrogenase subunit 2; Provisional
 11-323 1.14e-47

NADH dehydrogenase subunit 2; Provisional


The actual alignment was detected with superfamily member MTH00144:

Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 163.52  E-value: 1.14e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  11 PSHFCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIG-LLLNNLCLS 89
Cdd:MTH00144    4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGsLIMYNLSFS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  90 IFLMekLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---QMENLFIVMGCLSSVVGGVG 166
Cdd:MTH00144   84 WFSM--SLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdlyWLAYLLCVISVLSALVGSIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 167 GFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSAGNSTIFYLLSLg 246
Cdd:MTH00144  162 GLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLL- 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1181491981 247 fLGMSGIPPFIMFFGKVIVI--SSFCTFFLGILMFLLGAIISMYYYFNVMMLWSIVKFNVLIFNEGKSSFGLLVLMSIM 323
Cdd:MTH00144  241 -LSLGGLPPFLGFCSKLLVLisSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLL 318
 
Name Accession Description Interval E-value
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 11-323 1.14e-47

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 163.52  E-value: 1.14e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  11 PSHFCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIG-LLLNNLCLS 89
Cdd:MTH00144    4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGsLIMYNLSFS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  90 IFLMekLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---QMENLFIVMGCLSSVVGGVG 166
Cdd:MTH00144   84 WFSM--SLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdlyWLAYLLCVISVLSALVGSIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 167 GFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSAGNSTIFYLLSLg 246
Cdd:MTH00144  162 GLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLL- 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1181491981 247 fLGMSGIPPFIMFFGKVIVI--SSFCTFFLGILMFLLGAIISMYYYFNVMMLWSIVKFNVLIFNEGKSSFGLLVLMSIM 323
Cdd:MTH00144  241 -LSLGGLPPFLGFCSKLLVLisSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLL 318
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 22-294 6.12e-22

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 95.95  E-value: 6.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  22 IGAMISVSSAHWLGVWLGMELN---LFGMIPLLigKGQGQEIEAAIKYYFIQSVGSCFIIIG------------------ 80
Cdd:COG1007   113 LGMMLMASANDLLTLFLGLELLslsLYVLVAFR--RDDRRSSEAALKYFLLGALSSGFLLYGisllygatgslnlagiaa 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  81 -LLLNNLCLSIFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---------QMEN 150
Cdd:COG1007   191 aLAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLveafpglaaDWQL 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 151 LFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLM----MSIGGALSYFISYFFTCLIVFSILSVL--GIFE 224
Cdd:COG1007   271 LLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAagtpLGVSAALFYLLAYLFMNLGAFAVILLLsrKGGE 350

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1181491981 225 YSQIS--KSLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS---FCTFFLGILMfLLGAIISMYYYFNVM 294
Cdd:COG1007   351 AEEIEdlAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAaveAGLYWLAVIA-VLNSVISAYYYLRVV 424
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 17-332 1.91e-17

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 82.69  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  17 FMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLL-IGKGQGQEIEAAIKYYFIQSVGSCFIIIG--------------- 80
Cdd:TIGR01770 108 LLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAgLKRKSRFSTEAGLKYFILGAFSSGLLLFGisliygftgslnfed 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  81 --LLLNNLCL--SIFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---------Q 147
Cdd:TIGR01770 188 llLFLSNGMLniSLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFlyilfgfseA 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 148 MENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLM----MSIGGALSYFISYFFTCLIVFSILSVLGIF 223
Cdd:TIGR01770 268 WQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLagtlEGIKAVLFYIFIYALMSLGAFGVLSLLRSY 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 224 EYSQIS-----KSLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS--FCTFFLGILMFLLGAIISMYYYFNVMML 296
Cdd:TIGR01770 348 KDEWIEyisdfAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFAllKSGLYWLAVIAVLTSVIGAFYYLRVVKV 427

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1181491981 297 WSIVKFNVLIFNEGKSSFGLLVLMSIMLISGLWVML 332
Cdd:TIGR01770 428 MYFDKPERRIPSNPQSKAQSLLLSISALFILFLGLF 463
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 30-268 4.66e-13

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 68.49  E-value: 4.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  30 SAHWLGVWLGMELNLFGMIPLLIGKGQGQE-IEAAIKYYFIQSVGSCFIIIGLLL------------------NNLCLSI 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKSPRsSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelskaltGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  91 FLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSW-ISCFLLCSIQKVSPLFLLINIFQME-------NLFIVMGCLSSVV 162
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTpVSALLAATLVKAGGYGLIRRSLLYLpsspfiqQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 163 GGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMM----SIGGALSYFISY-FFTCLIVFSILSVLGIFEYSQ---ISKSLSA 234
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHgLFSAGLFLCAGSVIYRRVHTRnirDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1181491981 235 GNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAA 274
 
Name Accession Description Interval E-value
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 11-323 1.14e-47

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 163.52  E-value: 1.14e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  11 PSHFCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIG-LLLNNLCLS 89
Cdd:MTH00144    4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGsLIMYNLSFS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  90 IFLMekLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---QMENLFIVMGCLSSVVGGVG 166
Cdd:MTH00144   84 WFSM--SLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdlyWLAYLLCVISVLSALVGSIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 167 GFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSAGNSTIFYLLSLg 246
Cdd:MTH00144  162 GLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLL- 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1181491981 247 fLGMSGIPPFIMFFGKVIVI--SSFCTFFLGILMFLLGAIISMYYYFNVMMLWSIVKFNVLIFNEGKSSFGLLVLMSIM 323
Cdd:MTH00144  241 -LSLGGLPPFLGFCSKLLVLisSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLL 318
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 7-322 5.50e-44

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 153.78  E-value: 5.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981   7 FLIYPSHFCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNL 86
Cdd:MTH00011    2 MSTFPTMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  87 CLS-IFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMENLFIV--MGCLSSVVG 163
Cdd:MTH00011   82 FPSlLKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMtsMAAMSALAG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 164 GVGGFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSAGNSTIFYLL 243
Cdd:MTH00011  162 GLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLF 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 244 SLgFLGMSGIPPFIMFFGKVIVISSFCT--FFLGILMFLLGAIISMYYYFNVMMLWSIVKFNVLIFNEGKSSFGLLVLMS 321
Cdd:MTH00011  242 IM-LLSLGGLPPFTGFMPKLMAIETLTSnsMILILLVLIVGSLMNLFYYLNLIFNFMYLSPTFSSLKSAPYEPKTKILIS 320


                  .
gi 1181491981 322 I 322
Cdd:MTH00011  321 M 321
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 7-336 4.03e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 146.51  E-value: 4.03e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981   7 FLIYPSHFCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNL 86
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  87 CLSIFLME-KLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMeNLFIVMGCLSSVVGGV 165
Cdd:MTH00160   81 NLMLFNNIsSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINN-NFIIIIIILSAIIGAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 166 GGFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSaGNSTIFYLLSL 245
Cdd:MTH00160  160 GGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNN-KSKKIKFLLFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 246 GFLGMSGIPPFIMFFGKVIVISSFC--TFFLGILMFLLGAIISMYYY----FNVMMLWSIVKFNVLIFNEGKSSFGLLVL 319
Cdd:MTH00160  239 NLLSLGGLPPFLGFLPKWIIIQLLIsnNMFFLLFILIMSSLITLYFYlrisYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                         330
                  ....*....|....*..
gi 1181491981 320 MSIMLISGLWVMLILSN 336
Cdd:MTH00160  319 SFISLFGLILSSLLFLL 335
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 16-324 1.19e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 140.10  E-value: 1.19e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  16 FFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNLCLSIFLMEK 95
Cdd:MTH00200    9 FILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWGISE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  96 LF-------FMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMEN--LFIVMGCLSSVVGGVG 166
Cdd:MTH00200   89 MLgplsetlILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNsnILLLLGLLSVLVGGWG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 167 GFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSaGNSTIFYLLSLG 246
Cdd:MTH00200  169 GLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKT-KNPILSMLLGLT 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 247 FLGMSGIPPFIMFFGKVIVISSFCTFFLGILMF--LLGAIISMYYY----FNVMMLWSIVKFNVLIFNEGKSSFGLLVLM 320
Cdd:MTH00200  248 LLSLGGLPPLTGFFPKWLILQELSKQGLFIYATilLLGSLLSLFFYlrlsYLTLLTLSPNQINMMSSWRTKSNSNLLVGL 327


                  ....
gi 1181491981 321 SIML 324
Cdd:MTH00200  328 LLLL 331
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 14-334 2.04e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 139.04  E-value: 2.04e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  14 FCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNLCLSIFLM 93
Cdd:MTH00197    1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  94 EKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMENLFIVMGCLSSVVGGVGGFNQSKL 173
Cdd:MTH00197   81 SVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQSNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 174 RSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQIsKSLSAGNSTIFYLLSLGFLGMSGI 253
Cdd:MTH00197  161 RQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQ-YSNPESMSSNLVFLGLSFLSLGGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 254 PPFIMFFGKVIVISSFCT--FFLGILMFLLGAIISMYYYFNvmMLWSIVKFNVLIFNEGKSSFGLLVLMSIMLISGLWVM 331
Cdd:MTH00197  240 PPLSGFFLKWLILTSLLSsnISLITFMLILSTCFSLYYYLS--LAYKSLILSNWMINFLMKINLLYSGLFILLMMMLPLL 317


                  ...
gi 1181491981 332 LIL 334
Cdd:MTH00197  318 MIF 320
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 16-334 2.19e-36

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 134.29  E-value: 2.19e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  16 FFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNLCLSIFL--- 92
Cdd:MTH00041    9 LITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLSGSWSing 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  93 ----MEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMEN--LFIVMGCLSSVVGGVG 166
Cdd:MTH00041   89 plntLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNsnILILCGILSVLVGGWG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 167 GFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKsLSAGNSTIFYLLSLG 246
Cdd:MTH00041  169 GLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNK-LSQLNPISAFLFILS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 247 FLGMSGIPPFIMFFGKVIVISSFCT--FFLGILMFLLGAIISMYYYFNV-----MMLWSIVKFNVLIFNEGKSSFGLLVL 319
Cdd:MTH00041  248 ILSLGGLPPLTGFLNKFISLYCLIQnnSILISIILIIGSLLSLFFYLRIsfntsLTLFPQHSISLFSWRNSGNITVYGVI 327

                         330
                  ....*....|....*
gi 1181491981 320 MSIMLISGLWVMLIL 334
Cdd:MTH00041  328 LSILSSISILGLLLI 342
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 22-290 7.75e-35

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 130.04  E-value: 7.75e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  22 IGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNLCL---SIFLMEKLF- 97
Cdd:MTH00070   15 LGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWFTgewTIMNMQTPLp 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  98 ---FMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMEN--LFIVMGCLSSVVGGVGGFNQSK 172
Cdd:MTH00070   95 timLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNsnLLIIMGLLSTLIGGWGGLNQTQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 173 LRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSAgNSTIFYLLSLGFLGMSG 252
Cdd:MTH00070  175 LRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSK-NPTLTSMMMLTLLSLGG 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1181491981 253 IPPFIMFFGKVIVISSFCTFFLGIL--MFLLGAIISMYYY 290
Cdd:MTH00070  254 LPPTTGFIPKWLILQELTKQNLTTLatLMALSALLSLFFY 293
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 20-290 1.13e-33

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 126.88  E-value: 1.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  20 IWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNLCLSIFLMEKLF-- 97
Cdd:MTH00105   13 LFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYSGQWTITKLTnp 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  98 -----FMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMEN--LFIVMGCLSSVVGGVGGFNQ 170
Cdd:MTH00105   93 tastlMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINpnLLLTLAILSILIGGWGGLNQ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 171 SKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSvlgifeYSQISKSLSAGNS-----TIFYLLSL 245
Cdd:MTH00105  173 TQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLM------LNSSTTTLSLSHTwnktpLMTSLILL 246

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1181491981 246 GFLGMSGIPPFIMFFGKVIVISSFC---TFFLGILMFLLgAIISMYYY 290
Cdd:MTH00105  247 TLLSLGGLPPLTGFMPKWMIIQELTknnNIILPTLMAIT-ALLNLYFY 293
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 22-290 1.41e-33

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 126.48  E-value: 1.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  22 IGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNLCLS---IFLME---- 94
Cdd:MTH00112   15 LGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGqwdITQLTnpts 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  95 KLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMEN--LFIVMGCLSSVVGGVGGFNQSK 172
Cdd:MTH00112   95 CTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNptLLLTLAILSTLIGGWGGLNQTQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 173 LRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKSLSAgNSTIFYLLSLGFLGMSG 252
Cdd:MTH00112  175 LRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTK-SPTLNTTLMLTLLSLAG 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1181491981 253 IPPFIMFFGKVIVISSFCTFFLGIL--MFLLGAIISMYYY 290
Cdd:MTH00112  254 LPPLTGFMPKWLILQELTKQNMTPTatIMAMLSLLSLFFY 293
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 22-189 3.39e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 103.73  E-value: 3.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  22 IGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNN--------LCLSIFLM 93
Cdd:MTH00135   15 LGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAwltgqwdiQQMSHPLP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  94 EKLfFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQ-MENLFIVMGCLSSVVGGVGGFNQSK 172
Cdd:MTH00135   95 TTM-ITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPtNPTLLITLGLTSTLVGGWGGLNQTQ 173

                         170
                  ....*....|....*..
gi 1181491981 173 LRSMLAYSSIGHGGWMV 189
Cdd:MTH00135  174 LRKILAYSSIAHLGWMI 190
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 22-294 6.12e-22

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 95.95  E-value: 6.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  22 IGAMISVSSAHWLGVWLGMELN---LFGMIPLLigKGQGQEIEAAIKYYFIQSVGSCFIIIG------------------ 80
Cdd:COG1007   113 LGMMLMASANDLLTLFLGLELLslsLYVLVAFR--RDDRRSSEAALKYFLLGALSSGFLLYGisllygatgslnlagiaa 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  81 -LLLNNLCLSIFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---------QMEN 150
Cdd:COG1007   191 aLAAGGANSPLLLLGLVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLveafpglaaDWQL 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 151 LFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLM----MSIGGALSYFISYFFTCLIVFSILSVL--GIFE 224
Cdd:COG1007   271 LLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAagtpLGVSAALFYLLAYLFMNLGAFAVILLLsrKGGE 350

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1181491981 225 YSQIS--KSLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS---FCTFFLGILMfLLGAIISMYYYFNVM 294
Cdd:COG1007   351 AEEIEdlAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAaveAGLYWLAVIA-VLNSVISAYYYLRVV 424
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 19-289 6.64e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 95.10  E-value: 6.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  19 IIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLI-GKGQGQEIEAAIKYYFIQSVGSCFIIIGL---------------- 81
Cdd:MTH00196    1 MVALGILCLISSSNWLSVYLAIELQTLSLFILIAqNRGSGYSAEAGLKYFVLGALSSGLFLFGCallcgttgglhlsyin 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  82 LLNNLCLSI----FLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMENLFIVMGC 157
Cdd:MTH00196   81 LVLNSGQSFssvsVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 158 LSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMM----SIGGALSYFISYFFTCLIVFSILSVLGIFEYSQISKS-L 232
Cdd:MTH00196  161 FSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIgsfeSIQASLVYLFIYIIMSICVFSIILALNVYKNLIIEFSgL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 233 SAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISSFCT---FFLGILMFLLGAIISMYY 289
Cdd:MTH00196  241 SRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVyqyYLIFLLAVFCSVIAGVYY 300
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 9-268 4.75e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 93.54  E-value: 4.75e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981   9 IYPSHFCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLL-IGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLL---- 83
Cdd:MTH00199   95 GGQSSPILILIVALGSLLLVSSINWLSIYLAIELQTLTLFILVaLKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALlygl 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  84 --------NNLCLSIFLmEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMENLFIVM 155
Cdd:MTH00199  175 tgetsiqgINSILTGDV-GKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLIC 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 156 GCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMM----SIGGALSYFISYFFTCLIVFSILSVLG-----IFEYS 226
Cdd:MTH00199  254 AVLSIIYGAIGALNQTKIKRLLAYSGIGHMGFILFGVAIgsfeSIQASLIYMIIYVIMSICSFSIILSLKltkglIVEVS 333

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1181491981 227 QISKSlsagNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS 268
Cdd:MTH00199  334 GLSRK----NPVIALTLALTFLSIAGIPPLAGFLSKWLILLS 371
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
23-296 6.14e-18

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 84.49  E-value: 6.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  23 GAMISVSSAHWLGVWLGMELN---LFGMIPLliGKGQGQEIEAAIKYYFIQSVGSCFIIIG------------------- 80
Cdd:PRK05777  115 GMMVMVSANDLLTLFLGLELLslpLYALAAL--RRDRRRSLEAAIKYFVLGALASGFLLYGmsllygatgslsfagiaka 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  81 LLLNNLCLSIFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---------QMENL 151
Cdd:PRK05777  193 LADGSGNSLLLLFGLVFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLLvvafgglseDWQQV 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 152 FIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMM----SIGGALSYFISYFFTCLIVFSILSVL--GIFEY 225
Cdd:PRK05777  273 LAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAgtaeGYSAVLFYLLAYLFMTLGAFGVISLLrrKGGEA 352

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1181491981 226 SQIS--KSLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS---FCTFFLGILMfLLGAIISMYYYFNVMML 296
Cdd:PRK05777  353 ESISdfAGLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAaveAGLWWLAVIG-VLNSAIGAFYYLRVIKL 427
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 17-332 1.91e-17

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 82.69  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  17 FMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLL-IGKGQGQEIEAAIKYYFIQSVGSCFIIIG--------------- 80
Cdd:TIGR01770 108 LLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAgLKRKSRFSTEAGLKYFILGAFSSGLLLFGisliygftgslnfed 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  81 --LLLNNLCL--SIFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---------Q 147
Cdd:TIGR01770 188 llLFLSNGMLniSLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFlyilfgfseA 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 148 MENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLM----MSIGGALSYFISYFFTCLIVFSILSVLGIF 223
Cdd:TIGR01770 268 WQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLagtlEGIKAVLFYIFIYALMSLGAFGVLSLLRSY 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 224 EYSQIS-----KSLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS--FCTFFLGILMFLLGAIISMYYYFNVMML 296
Cdd:TIGR01770 348 KDEWIEyisdfAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFAllKSGLYWLAVIAVLTSVIGAFYYLRVVKV 427

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1181491981 297 WSIVKFNVLIFNEGKSSFGLLVLMSIMLISGLWVML 332
Cdd:TIGR01770 428 MYFDKPERRIPSNPQSKAQSLLLSISALFILFLGLF 463
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 12-294 4.07e-17

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 82.21  E-value: 4.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  12 SHFCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQ---------GQEIEAAIKYYFIQSVGSCFIIIGLL 82
Cdd:MTH00198  189 SGFALVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQpgshfpspgNTPPESGLKYWILGAMSSGFYLFGCA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  83 L---------------------NNLCLSIFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFL 141
Cdd:MTH00198  269 LyfgftgnegmlgtilsatletTNIELRQGSLGYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYIL 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 142 LINIFQMENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMV----GGLMMSIGGALSYFISYFFTCLIVFSIL 217
Cdd:MTH00198  349 LTSLVITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFILigvsAGTYESLQASWTYAVTYLVSALASFTVI 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 218 SVLGIFEYSQISKS--------------------LSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVI---------SS 268
Cdd:MTH00198  429 CTLEEFGTRTPTSRqrdgsfgnynlvrrlvdltiLSRGQPYIAFSLAIVFLSLAGIPPLLGFLGKWFILvgsikiafsSS 508

                         330       340
                  ....*....|....*....|....*.
gi 1181491981 269 FCTFFLGILMFLLGAIISMYYYFNVM 294
Cdd:MTH00198  509 LSIYYLVALFAIICTCISAFYYIRIV 534
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 14-295 4.66e-14

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 72.49  E-value: 4.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  14 FCFFMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLL---------- 83
Cdd:COG0651   110 YPLFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLlygatgtlnm 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  84 -------NNLCLSIFLMEKLFFMVGLVMKLGIVPFYFWVPS---------------VMEKVSWISCFLLCSIqkvspLFL 141
Cdd:COG0651   190 adlaarlAELDPGLLLAAFALLLVGFGIKAALFPLHFWLPDaypaapspvsallsgLLTKVGVYAILRVLTL-----LFG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 142 LINIFQMENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMM----SIGGALSYFISY-FFTCLIVFSI 216
Cdd:COG0651   265 ADPALFLGTLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLgtplGLAGALFHLLNHaLAKALLFLAA 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 217 LSVLGIFEYSQISK--SLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISSF--CTFFLGILMFLLGAIISMYYYFN 292
Cdd:COG0651   345 GAIERATGTRDLDKlgGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAAleAGAWLLAAVLLLSSLLTLAYFVR 424


                  ...
gi 1181491981 293 VMM 295
Cdd:COG0651   425 IFG 427
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 30-268 4.66e-13

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 68.49  E-value: 4.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  30 SAHWLGVWLGMELNLFGMIPLLIGKGQGQE-IEAAIKYYFIQSVGSCFIIIGLLL------------------NNLCLSI 90
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYWGKSPRsSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdelskaltGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  91 FLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSW-ISCFLLCSIQKVSPLFLLINIFQME-------NLFIVMGCLSSVV 162
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTpVSALLAATLVKAGGYGLIRRSLLYLpsspfiqQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 163 GGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMM----SIGGALSYFISY-FFTCLIVFSILSVLGIFEYSQ---ISKSLSA 234
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHgLFSAGLFLCAGSVIYRRVHTRnirDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1181491981 235 GNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS 268
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAA 274
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
97-296 1.37e-11

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 65.07  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  97 FFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---------QMENLFIVMGCLSSVVGGVGG 167
Cdd:PRK02504  215 FVIAGIAFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAGFALAIRLLvtafpsfdeQWKLLFTALAILSMVLGNVVA 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 168 FNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYF----------FTCLIVFSILSVLG-IFEYSqiskSLSAGN 236
Cdd:PRK02504  295 LAQTSMKRMLAYSSIGQAGFVMIGLVAGTEAGYASMVFYLlaylfmnlgaFACVILFSLRTGTDqISDYA----GLYQKD 370

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 237 STIFYLLSLGFLGMSGIPPFIMFFGKVIVissfctFFLG--------ILMFLLGAIISMYYYFNV--MML 296
Cdd:PRK02504  371 PLLTLGLSLCLLSLGGIPPLAGFFGKIYL------FWAGwqaglyllVLVGLVTSVISIYYYIRVikMMV 434
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 57-268 4.82e-09

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 57.41  E-value: 4.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  57 GQEIEAAIKYYFIQSVGSCFIIIGLLL--------------NNLCLSIFLMEKL---FFMVGLVMKLGIVPFYFWVPSVM 119
Cdd:PRK08376  168 WEAIEAGIKYMFVGSLASSMVLLGIALlygqygtlnmaylaVKMSENPTVVAKIalaLFIAGLAMKSGAVPVHMWLPDAY 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 120 EKV-SWISCFLLC-SIQKVSPLF--------LLINIFQMENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMV 189
Cdd:PRK08376  248 PAApSSISAMLLViKQAGLYALArvlfsiygPAINLATVGWVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYML 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 190 GGL----------------MMSIGGALSYFISY-------FFTCLIVFSILSVLGIFEYSQISKSLSAgnSTIFYLlsLG 246
Cdd:PRK08376  328 LGLgvglaalgdpamasygEIALAGGIYHIVNHalykallFLTAGAVIYETGTRNLNELGGLARTMPK--TTIAFL--IG 403

                         250       260
                  ....*....|....*....|..
gi 1181491981 247 FLGMSGIPPFIMFFGKVIVISS 268
Cdd:PRK08376  404 AAAIVGLPPFNGFASKWLIYES 425
ndhB CHL00049
NADH dehydrogenase subunit 2
 97-296 5.51e-08

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 54.24  E-value: 5.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  97 FFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF---------QMENLFIVMGCLSSVVGGVGG 167
Cdd:CHL00049  219 FITVGIGFKLSLAPFHQWTPDVYEGSPTPVVAFLSVTSKVAASALATRIFdipfyfssnEWHLLLEILAILSMILGNLIA 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 168 FNQSKLRSMLAYSSIGHGGWMVGGLMMS-----IGGALSYFISYFFTCLIVFSILSVLG-------IFEYSqiskSLSAG 235
Cdd:CHL00049  299 ITQTSMKRMLAYSSIGQIGYVIIGIIVGdsndgYASMITYMLFYIFMNLGTFACIVLFGlrtgtdnIRDYA----GLYTK 374

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1181491981 236 NSTIFYLLSLGFLGMSGIPPFIMFFGKviVISSFCT----FFLGILMFLLGAIISMYYYFNVMML 296
Cdd:CHL00049  375 DPFLALSLALCLLSLGGIPPLAGFFGK--LYLFWCGwqagLYFLVSIGLLTSVISIYYYLKIIKL 437
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 151-333 3.43e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 48.43  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 151 LFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHggwmVGGLMMSIGGALSYFISYFFTCLIVFSILSVL-----GIFEY 225
Cdd:PRK12667  297 ILIILGAVSAIIGALMMVVQKDVKRLLAYSTISH----MGYIFMGIGIGTQLGLAAALFHIINHAIAKSLlflasGVFIH 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 226 SQISKSLS----AGNSTIF--YLLSLGFLGMSGIPPFIMFFGKVIVISSFCT--FFLGILMFLLGAIISMYYYFNVMML- 296
Cdd:PRK12667  373 AAGTRDIDelagLGRKMPIasFAFLIGALSLVGIPPLNGFFSKLLLFNALLEsgFYLPALVLLIASAISLVGYFRAWYSl 452

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1181491981 297 -WSIVKF--NVLIFNEGKSSFGLLVLMSIMLISGLWVMLI 333
Cdd:PRK12667  453 fFGKPKSgeEVEHKESPSMSVVILVLALAVLILGILALFL 492
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 89-325 8.84e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 46.40  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  89 SIFLMEKLFFMVGLV--MKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQMENLFIVMgcLSSVVGGVG 166
Cdd:MTH00091   52 LLFLLFSFGYFQFLIlmMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLL--FGLLICFFQ 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 167 GFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSVlgifeysqiskslsagNSTIFYLLSLG 246
Cdd:MTH00091  130 MFLLKSYKNLLILSSTESFNWLILSFFFSFFNVFFLFFYYFLLMLFLIPKFNN----------------VNKLNFVSWET 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1181491981 247 FLGMSGIPPFIMFFGKVIVISSFCTFFLGILMFLLGAIISMYYYFNVMMLWSIVKFNVLIFNEGKSSFGLLVLMSIMLI 325
Cdd:MTH00091  194 LLVFMNLPFSVTFFVKIFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFFFFFLPLMLLSL 272
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 96-294 1.25e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 46.65  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  96 LFFMVGLVMKLGIVPFYFW-VPSVMEKVSWISCFLLCSIQKVSpLFLLINIFQ-------------MENLFIVMGCLSSV 161
Cdd:PRK12662  213 LFIMVGLFIKAALFPFHKWlIQAYSEAPSFISVFFSGTSTKVM-IYLIIRIVYdvfkanfvfttlpFNNVFMILAALAIV 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 162 VGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSIL-----------SVLGIFEYSQISK 230
Cdd:PRK12662  292 FGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVNHSIVKSALfmvsgsisyhfGTTKLEDCLNLWK 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1181491981 231 SLsAGNSTIFYLLSLGFLGMsgiPPFIMFFGKVIVISSF--CTFFLGILMFLLGAIISMYYYFNVM 294
Cdd:PRK12662  372 SM-PKITLAFVLLSLSLIGM---PPTSGFVAKWYILDAFikSNAWIGLVVLLVGSGLSVIYVWKIV 433
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
50-296 3.65e-05

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 45.33  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  50 LLIGKGQGQEIEAAIKYYFIQSVGSCF--IIIGLL------LNNLCLSIFLME----------KLFFMVGLVMKLGIVPF 111
Cdd:PRK12663  147 LITLGQEREQLRGAIKYVVLNLIGSWLflLGIGLLygtfgtLNMAHIAMRLNDmgdtatlttiALLFLLAFGMKAALFPF 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 112 yFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQM---------ENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSI 182
Cdd:PRK12663  227 -MWLPAAYHTPNTEVAALFAALLTKVGIYALIRVFTLlfpqerellHPLLATMAAITMVIGALGALAYKDIRRIAGYQVI 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 183 GHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILS-VLGIFEYSQISKSLS-----AGNSTIFYLLSL-GFLGMSGIPP 255
Cdd:PRK12663  306 SSIGFILLGLALGTPAGINGAIFYLVHDMVVKTALFlIAGSLVRLTGYRSLQylgglYRKEPLFGALFLiLIFAIGGLPP 385

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1181491981 256 FIMFFGKVIVISSFCT--FFLGILMFLLGAIISMYYYFNVMML 296
Cdd:PRK12663  386 FSGFWGKVLLVQGALDngAYILLALMLITSLITMYSLFRIFFL 428
PRK12665 PRK12665
putative monovalent cation/H+ antiporter subunit D; Reviewed
 147-266 6.24e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237165 [Multi-domain]  Cd Length: 521  Bit Score: 44.57  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 147 QMENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILS-VLGIFEY 225
Cdd:PRK12665  271 GLDTLLMVVALLTMVVGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTVAGLSGAIYYVAHHITVQTTLFlVVGLIER 350

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1181491981 226 SQISKSLS--AGNSTIFYLLSLGF----LGMSGIPPFIMFFGKVIVI 266
Cdd:PRK12665  351 QAGSSSLRrlGGLAKASPLLAVLFfvpaLNLGGIPPFSGFIGKVALL 397
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 97-266 1.72e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 43.33  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  97 FFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIF------------QMENLFIVMGCLSSVVGG 164
Cdd:PRK08375  207 FVLLALALKAAVFPLHTWLPRAYPAAPPVVTALLSGLVTKVAVYALIRIYftvfggdfrfalGLGWLLAVLALLSMLVGS 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 165 VGGFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFT-CLIVFSILSVLGIFEYSQISKSLS--AGNSTIFY 241
Cdd:PRK08375  287 LAALGQDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLHhALMKGALFLAAGAIEVTYGTRRLSelSGLGRRMP 366

                         170       180
                  ....*....|....*....|....*....
gi 1181491981 242 LLSLGF----LGMSGIPPFIMFFGKVIVI 266
Cdd:PRK08375  367 LTAAAFavasLSLIGVPPTSGFVSKWYLV 395
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 36-335 3.05e-04

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 42.22  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  36 VWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLL-------------------------NNLCLSI 90
Cdd:PRK06458  133 MWVAIEATTLSSALLVGIYRTRASLEAAWKYIIICSVGVAFALFGTILvyanaatvmgdgemailwtellkhaSLLDPTL 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  91 FLMEKLFFMVGLVMKLGIVPFYFWVPSV-MEKVSWISCFLLCSIQKVSpLFLLINIFQM----------ENLFIVMGCLS 159
Cdd:PRK06458  213 MKLAFVFLLIGFGTKVGLFPMHAWLPDAhSEAPSPVSALLSGVLLNVA-LYAVLRYYILidaaigsdfpGRLLLIFGLLS 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 160 SVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLmmSIGGALSYF------ISYFFT-CLIVFSILSVLGIFEYSQIS--K 230
Cdd:PRK06458  292 VLVAAFFLLRQRDIKRLFAYSSIEHMGLIAFAL--GIGGPLGIFaallhmLNHSLTkSAIFFASGNVLQKYGTRDINviR 369

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 231 SLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKVIVISS-----FCTFFLGILMFLLGAIISMYYYFNVMMLWSiVKFNVL 305
Cdd:PRK06458  370 GLLKVSPLTGWGLMLGALAIAGMPPFGVFISEFLILTAglargPLLIAILLLLLLTLAFAALVRRVAGMVFGE-PPEAVN 448

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1181491981 306 IFNEGK-SSFGLLVLMSIMLISGLWVMLILS 335
Cdd:PRK06458  449 RGDLGWlTTSPMFVHLVLVLVLGLYIPQPLV 479
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 60-291 4.62e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 41.66  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  60 IEAAIKYYFIQSVGSCFIIIGLLL-----------------------NNLCLSIFLMEKLFFMVGLVMKLGIVPFYFWVP 116
Cdd:PRK08676  151 IDAALKYIFIASTAMIFAFIGLIFlfsltrqalgtgtlnwtelaahaSLLSPSVLGASFLFIFIGFLAKSGLVPFHTWLP 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 117 SVMEKV-SWISCFLLCSIQKVSpLFLLINIF----------QMENLFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHG 185
Cdd:PRK08676  231 AAYAKApSVVSALLSGTVLNIG-IYGILRLSallrqsgaaeQFSNVLIGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHM 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 186 GWMVGGLmmSIGGALSYFISYFFT---CLIVFSILSVLGIFeYSQISKSLSAGNSTIFYL-------LSLGFLGMSGIPP 255
Cdd:PRK08676  310 GLMLLGI--GIGTPLALFWMLFHMlahSLVKSGLFFSAGIL-HRQYRSDRFDRIFDVFRLqpvaawgVILGSAAIIGMPP 386

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1181491981 256 FIMFFGKV---IVISSFCTFFLGILMFLLGAIISMYYYF 291
Cdd:PRK08676  387 FPLFLSKFfilLQLGGISVWLVLAVLLLLLLAASSFAIF 425
PRK06525 PRK06525
hydrogenase 4 subunit D; Validated
 110-268 1.02e-03

hydrogenase 4 subunit D; Validated


Pssm-ID: 180606 [Multi-domain]  Cd Length: 479  Bit Score: 40.73  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 110 PFYFWVPSVMEKVSWISCFL-LCSIQKVSPLFLLINIFQMENL-------FIVMGCLSSVVGGVGGFNQSKLRSMLAYSS 181
Cdd:PRK06525  225 PFYSWLPDAMEAPTPASAYLhAASMVKVGVYIFARAIQSMGPIphvigyvGAVMAIVTLLYGFLMYLPQQDMKRLLAYST 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 182 IGHGGWMVGGLMMSIGG---ALSYFISYFFTCLIVFSIL-SVLGIFEYSQISKSLS--AGNSTIFYLLSLGF----LGMS 251
Cdd:PRK06525  305 ITQLGYMFFGLSLAILGsrlALEGSIAYIFNHAFAKSLFfLVAGALSYSCGTRLLPrlRGVLKKLPLVGVGFcvaaLAIT 384

                         170
                  ....*....|....*..
gi 1181491981 252 GIPPFIMFFGKVIVISS 268
Cdd:PRK06525  385 GVPPFNGFFSKFPIFAA 401
PRK12650 PRK12650
DUF4040 family protein;
110-189 1.36e-03

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 40.41  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 110 PFYFWVPSVMEKVSWISCFLLCS---------IQKVSPLFLLINIFQMenLFIVMGCLSSVVGGVGGFNQSKLRSMLAYS 180
Cdd:PRK12650  226 PFHFWLPEAMAAITPVSAFLHAAavvkagiylLLRFSPVFHDVAVWNW--LLIIVGMITALMGAVFAVQKTDLKKLTAYS 303


                  ....*....
gi 1181491981 181 SIGHGGWMV 189
Cdd:PRK12650  304 TVSQLGWIV 312
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 17-291 2.43e-03

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 39.75  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  17 FMIIWIGAMISVSSAHWLGVWLGMELNLFGMIPLLIGKGQGQEIEAAIKYYFIQSVGSCFIIIGLLLNNLCLSIFLMEKL 96
Cdd:PRK08377  114 FLLLMLGATGMIATGDIFNLFVFMEITAITAYALTAYNKTGEAAEASMKYIVLGGIGSSFFLIGVALIYGATGTLNMAHI 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  97 -----------------FFMVGLVMKLGIVPFYFWVPSVMEKVSW-ISCFLLCSIQKVSPLFLLINIFQMEN-------- 150
Cdd:PRK08377  194 aqlagtidptvaqvglaLLIFGLAVEAELFPLNAWAPDAYQAAPHpITVMFSAFVVKAGLYAMARILYLMQNangwssvl 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981 151 -LFIVMGCLSSVVGGVGGFNQSKLRSMLAYSSIGHGGWMVGGLMMSIGGALSYFISYFFTCLIVFSILSV--------LG 221
Cdd:PRK08377  274 kLVIIMATLTVFFAELSALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLFLavgyvgitLG 353

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1181491981 222 IFEYSQIsKSLSAGNSTIFYLLSLGFLGMSGIPPFIMFFGKV-IVISSFCTFFLGILMFLLGA-IISMYYYF 291
Cdd:PRK08377  354 GTEIEKF-EGLGKRMPLTALALTIGALSTVGIPLFNVFWSKFrIILAGLSAGYTWPVALVLGAsVVEAVYYF 424
PRK12649 PRK12649
putative monovalent cation/H+ antiporter subunit A; Reviewed
 90-189 9.80e-03

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 183649 [Multi-domain]  Cd Length: 789  Bit Score: 37.89  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1181491981  90 IFLMEKLFFMVGLVMKLGIVPFYFWVPSVMEKVSWISCFLLCSIQKVSPLFLLINIFQM----ENLFIVM---GCLSSVV 162
Cdd:PRK12649  212 LFLITLILIFIGAAAKSAQGPFYIWLPNAMEAPTPVSAFLHSATMVKAGVYLVARIHPIfsgtEAWFILVsgtGMITMVL 291

                          90       100
                  ....*....|....*....|....*..
gi 1181491981 163 GGVGGFNQSKLRSMLAYSSIGHGGWMV 189
Cdd:PRK12649  292 AGFLAFRQTDIKAILAYSTISQLAYLM 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH