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Conserved domains on  [gi|56548770|ref|YP_161229|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Macrotis lagotis]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.59e-38

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.12  E-value: 3.59e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.59e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.12  E-value: 3.59e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
6-98 9.69e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 61.04  E-value: 9.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770    6 LNLIMAFSLALLGVLiYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVKISASH 85
Cdd:pfam00420  4 LLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTH 82

                         90
                 ....*....|...
gi 56548770   86 GNDYVQNLNLLQC 98
Cdd:pfam00420 83 GTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.64e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 37.35  E-value: 1.64e-04
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770 12 FSLALLGVLIyRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVKISASHGNDYVQ 91
Cdd:COG0713 14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


               ....*
gi 56548770 92 NLNLL 96
Cdd:COG0713 93 DLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.59e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 123.12  E-value: 3.59e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.66e-29

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 99.54  E-value: 6.66e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.66e-28

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 98.50  E-value: 1.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.90e-25

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 90.43  E-value: 2.90e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 8-96 4.06e-14

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 61.88  E-value: 4.06e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   8 LIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVKISASHGN 87
Cdd:MTH00181  5 FISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGS 84


                ....*....
gi 56548770  88 DYVQNLNLL 96
Cdd:MTH00181 85 DHLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
6-98 9.69e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 61.04  E-value: 9.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770    6 LNLIMAFSLALLGVLiYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVKISASH 85
Cdd:pfam00420  4 LLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRTH 82

                         90
                 ....*....|...
gi 56548770   86 GNDYVQNLNLLQC 98
Cdd:pfam00420 83 GTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 4.13e-13

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 59.55  E-value: 4.13e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 56548770  81 ISASHGNDYVQNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.41e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 49.20  E-value: 3.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYfhMSSASMAPLILLVFSACEAGVGLALLVK 80
Cdd:MTH00188  2 FFSMILVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSY--MEKELYLSLVLLTFAACEASVGLALLVS 79

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00188 80 LIRSHGSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 2.85e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 47.15  E-value: 2.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   9 IMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMapLILLVFSACEAGVGLALLVKISASHGND 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFSSSGLISFSSYLF--LIILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 56548770  89 YVQNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 9-92 1.04e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 45.15  E-value: 1.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   9 IMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMapLILLVFSACEAGVGLALLVKISASHGND 88
Cdd:MTH00162  8 LFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFL--LFFLTFSVCEGALGLSILVSMIRSHGND 85


                ....
gi 56548770  89 YVQN 92
Cdd:MTH00162 86 YFSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 1.10e-07

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 45.51  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770   1 MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMApLILLVFSACEAGVGLALLVK 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGMLA-IVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 56548770  81 ISASHGNDYVQNLNLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.64e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 37.35  E-value: 1.64e-04
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56548770 12 FSLALLGVLIyRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVKISASHGNDYVQ 91
Cdd:COG0713 14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


               ....*
gi 56548770 92 NLNLL 96
Cdd:COG0713 93 DLNEL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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