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Conserved domains on  [gi|57165373|ref|NP_000828|]
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protein lifeguard 1 [Homo sapiens]

Protein Classification

Pro-rich and LFG_like domain-containing protein( domain architecture ID 12172238)

Pro-rich and LFG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 151-367 3.08e-124

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 356.47  E-value: 3.08e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 151 NWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVA 230
Cdd:cd10428   1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 231 LSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEI 310
Cdd:cd10428  81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 57165373 311 VYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIG 367
Cdd:cd10428 161 VYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 43-139 9.02e-13

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


:

Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 65.83  E-value: 9.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPygqPGYPHGPSPYPQGGyPQGPYPQGGY--------PQGPYPQEGYPQGPYPQGGY-----PQGPYPQSPF 109
Cdd:pfam15240  50 PPGGFPPQP---PASDDPPGPPPPGG-PQQPPPQGGKqkpqgpppQGGPRPPPGKPQGPPPQGGNqqqgpPPPGKPQGPP 125

                          90       100       110
                  ....*....|....*....|....*....|
gi 57165373   110 PPNPYGQPQVFPGQDPDSPQHGNYQeeGPP 139
Cdd:pfam15240 126 PQGGGPPPQGGNQQGPPPPPPGNPQ--GPP 153
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 151-367 3.08e-124

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 356.47  E-value: 3.08e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 151 NWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVA 230
Cdd:cd10428   1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 231 LSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEI 310
Cdd:cd10428  81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 57165373 311 VYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIG 367
Cdd:cd10428 161 VYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 159-366 2.82e-39

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 138.85  E-value: 2.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   159 QAFIRKVFLVLTLQLSVTlSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRK-HPWNLVALSVLTAS 237
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYsSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   238 LSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGA 317
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 57165373   318 LLFTCFLAVDTQLLLgNKQLSLSPEEYVFAALNLYTDIINIFLYILTII 366
Cdd:pfam01027 160 LLFSGFILYDTQRII-KRYGEYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 158-368 3.19e-27

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 107.57  E-value: 3.19e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 158 RQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCcGDFRRKHPWNLVALSVLTA- 236
Cdd:COG0670  19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAl 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 237 ---SLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYA 313
Cdd:COG0670  98 mglTLSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 57165373 314 SLGALLFTCFLAVDTQLLlgnKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGR 368
Cdd:COG0670 178 VAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGG 229
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 43-139 9.02e-13

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 65.83  E-value: 9.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPygqPGYPHGPSPYPQGGyPQGPYPQGGY--------PQGPYPQEGYPQGPYPQGGY-----PQGPYPQSPF 109
Cdd:pfam15240  50 PPGGFPPQP---PASDDPPGPPPPGG-PQQPPPQGGKqkpqgpppQGGPRPPPGKPQGPPPQGGNqqqgpPPPGKPQGPP 125

                          90       100       110
                  ....*....|....*....|....*....|
gi 57165373   110 PPNPYGQPQVFPGQDPDSPQHGNYQeeGPP 139
Cdd:pfam15240 126 PQGGGPPPQGGNQQGPPPPPPGNPQ--GPP 153
PHA03247 PHA03247
large tegument protein UL36; Provisional
 43-131 5.60e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 5.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPYGQPGYPHGPSPYPQggyPQGPYPqggypqgPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVFPG 122
Cdd:PHA03247 2887 ARPAVSRSTESFALPPDQPERPPQ---PQAPPP-------PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956


                  ....*....
gi 57165373   123 QDPDSPQHG 131
Cdd:PHA03247 2957 GAVPQPWLG 2965
KLF1_N cd21581
N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as ...
 42-111 3.69e-04

N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as Krueppel-like factor 1 or Erythroid Kruppel-like Factor/EKLF) was the first Kruppel-like factor discovered. It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains. EKLF ablation in mouse embryos produces a lethal anemic phenotype, causing death by embryonic day 14, and natural mutations lead to beta+ thalassemia in humans. However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, suggesting other factors may be involved. KLF1 functions as a transcriptional activator. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF1, which is related to the N-terminal domains of KLF2 and KLF4.


Pssm-ID: 409227 [Multi-domain]  Cd Length: 278  Bit Score: 41.95  E-value: 3.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57165373  42 YPQ-----PPFQPSPYGQPGYPHGPSPYPQggyPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPP 111
Cdd:cd21581 187 YPQqhpsvVAFPDSRFGPLSGPQALTPDPQ---HYGYFQLFRHNAALFPDYAHSPGPGHLPLGQQPLLPDPPLPP 258
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
39-78 5.12e-04

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 41.16  E-value: 5.12e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 57165373  39 GAPYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGG 78
Cdd:COG3416 105 PGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSGGG 144
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 39-140 2.86e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    39 GAPYPQPPFQPSPYGQPGYPhgPSPYPQggYPQGPYPQGGYPqgPYPQEGYPQ-------GPYPQGGYPQGPYPQSPFPP 111
Cdd:TIGR01628 401 YGQGPQQQFNGQPLGWPRMS--MMPTPM--GPGGPLRPNGLA--PMNAVRAPSrnaqnaaQKPPMQPVMYPPNYQSLPLS 474

                          90       100
                  ....*....|....*....|....*....
gi 57165373   112 NPYGQPQVFPGQDPDSPQHGNYQEEGPPS 140
Cdd:TIGR01628 475 QDLPQPQSTASQGGQNKKLAQVLASATPQ 503
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 39-157 6.78e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 38.60  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   39 GAPYPQ---PPFQPSPYGQPGyPHGP----SPYPQGGYPQ-GPYPQGGYPQ-GPYPQEGYPQ-GPYPQGGYPQ-GPYPQS 107
Cdd:NF033839 381 ETPKPEvkpQPEKPKPEVKPQ-PEKPkpevKPQPEKPKPEvKPQPEKPKPEvKPQPEKPKPEvKPQPEKPKPEvKPQPET 459

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57165373  108 PFP--------PNPYGQPQV-FPGQDPDSPQH--------GNYQEEGPPSYYDNQDFPATNWDDKSI 157
Cdd:NF033839 460 PKPevkpqpekPKPEVKPQPeKPKPDNSKPQAddkkpstpNNLSKDKQPSNQASTNEKATNKPKKSL 526
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 151-367 3.08e-124

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 356.47  E-value: 3.08e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 151 NWDDKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRKHPWNLVA 230
Cdd:cd10428   1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 231 LSVLTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEI 310
Cdd:cd10428  81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 57165373 311 VYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIG 367
Cdd:cd10428 161 VYASLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 154-367 2.15e-56

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 183.96  E-value: 2.15e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 154 DKSIRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSyavFFISLIVLSCCGDFRRKHPWNLVALSV 233
Cdd:cd10429  23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLIS---LIGSLILLIALYWKRHSHPVNLILLSL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 234 LTASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIF-IRNRILEIVY 312
Cdd:cd10429 100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILLALIFQFfPYSPTFELVY 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 57165373 313 ASLGALLFTCFLAVDTQLLLGNkqlsLSPEEYVFAALNLYTDIINIFLYILTIIG 367
Cdd:cd10429 180 AGLGALLFSGYIVYDTQLIMKR----LSPDEYILAAISLYLDIINLFLSILRILA 230
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 157-367 3.83e-46

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 156.42  E-value: 3.83e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 157 IRQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKgfvrenvwtYYVSYAVFF-ISLIVLSC-CGDFRRKHPWNLVALSVL 234
Cdd:cd06181   1 STKDFLRKVYMILALQLLLTAATATAFTVCDPGW---------YWSPALMGLlTSMLALMAtAAMIRAKMPVNLILLFGF 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 235 TASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYAS 314
Cdd:cd06181  72 TGLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAA 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 57165373 315 LGALLFTCFLAVDTQLLLGNkqLSLSPEEYVFAALNLYTDIINIFLYILTIIG 367
Cdd:cd06181 152 VGLVLFCGFLLYDTQLIIHK--AEVGPEDYINACISLYLDIINIFIRLLTILA 202
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 159-366 2.82e-39

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 138.85  E-value: 2.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   159 QAFIRKVFLVLTLQLSVTlSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCCGDFRRK-HPWNLVALSVLTAS 237
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYsSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   238 LSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGA 317
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 57165373   318 LLFTCFLAVDTQLLLgNKQLSLSPEEYVFAALNLYTDIINIFLYILTII 366
Cdd:pfam01027 160 LLFSGFILYDTQRII-KRYGEYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 158-368 3.19e-27

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 107.57  E-value: 3.19e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 158 RQAFIRKVFLVLTLQLSVTLSTVSVFTFVAEVKGFVRENVWTYYVSYAVFFISLIVLSCcGDFRRKHPWNLVALSVLTA- 236
Cdd:COG0670  19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTAl 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 237 ---SLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYA 313
Cdd:COG0670  98 mglTLSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLAIS 177

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 57165373 314 SLGALLFTCFLAVDTQLLlgnKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGR 368
Cdd:COG0670 178 VAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGG 229
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 158-367 2.47e-22

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 93.39  E-value: 2.47e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 158 RQAFIRKVFLVLTLQLSVTlSTVSVFTFVAEVKgFVRENVWTYYVSYAVFFISLIVLSccgdFRRKHP---WNLVALSVL 234
Cdd:cd10432   2 LRSFMKKVYGLMAAGLLLT-AVGAYVGASTPAL-LLIAGSPLMWVLLIAELALVFGLS----FRINKMsvaTALPLFFAF 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 235 TASLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYAS 314
Cdd:cd10432  76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 57165373 315 LGALLFTCFLAVDTQLL--LGNKQLSLSPEE-YVFAALNLYTDIINIFLYILTIIG 367
Cdd:cd10432 156 IGVLIFSGLIAYDTQRIkrMYEAGGGESGYKdAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 173-367 1.62e-14

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 71.46  E-value: 1.62e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 173 LSVTLSTVSVFTFVAEVKGFVrenvwtyYVSYAVFFISLIVLSCCGDFRRKHPWNLVALSVLT----ASLSYMVGMIASF 248
Cdd:cd10433  14 LSMTLAFSALGAGVSMAGGSP-------IMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTgfmgYTLGPILNMYLAL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 249 YNTEAVIM-AVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSMVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVD 327
Cdd:cd10433  87 PNGGQIIMtALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYD 166

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 57165373 328 TQLLLGNKQLSlspeeYVFAALNLYTDIINIFLYILTIIG 367
Cdd:cd10433 167 TSRIIHGGETN-----YIMATVSLYVSIYNLFVSLLNLLG 201
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 43-139 9.02e-13

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 65.83  E-value: 9.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPygqPGYPHGPSPYPQGGyPQGPYPQGGY--------PQGPYPQEGYPQGPYPQGGY-----PQGPYPQSPF 109
Cdd:pfam15240  50 PPGGFPPQP---PASDDPPGPPPPGG-PQQPPPQGGKqkpqgpppQGGPRPPPGKPQGPPPQGGNqqqgpPPPGKPQGPP 125

                          90       100       110
                  ....*....|....*....|....*....|
gi 57165373   110 PPNPYGQPQVFPGQDPDSPQHGNYQeeGPP 139
Cdd:pfam15240 126 PQGGGPPPQGGNQQGPPPPPPGNPQ--GPP 153
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 39-139 9.11e-13

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 65.83  E-value: 9.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    39 GAPYPQPPFQPSPYGQPGYPHGP----SPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGG--YPQGPYPQSPFPPN 112
Cdd:pfam15240  66 GPPPPGGPQQPPPQGGKQKPQGPppqgGPRPPPGKPQGPPPQGGNQQQGPPPPGKPQGPPPQGGgpPPQGGNQQGPPPPP 145

                          90       100
                  ....*....|....*....|....*..
gi 57165373   113 PyGQPQvfpGQDPDSPQHGNYQeeGPP 139
Cdd:pfam15240 146 P-GNPQ---GPPQRPPQPGNPQ--GPP 166
PHA03247 PHA03247
large tegument protein UL36; Provisional
 43-131 5.60e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 5.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPYGQPGYPHGPSPYPQggyPQGPYPqggypqgPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVFPG 122
Cdd:PHA03247 2887 ARPAVSRSTESFALPPDQPERPPQ---PQAPPP-------PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956


                  ....*....
gi 57165373   123 QDPDSPQHG 131
Cdd:PHA03247 2957 GAVPQPWLG 2965
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 41-141 6.01e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 6.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    41 PYPQP----PFQPSPYG-QPGYPHGPSPYPQGGYP------QGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYP-QSP 108
Cdd:pfam03154 265 PLPQPslhgQMPPMPHSlQTGPSHMQHPVPPQPFPltpqssQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPrEQP 344

                          90       100       110
                  ....*....|....*....|....*....|...
gi 57165373   109 FPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSY 141
Cdd:pfam03154 345 LPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPH 377
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 228-365 6.74e-09

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 55.31  E-value: 6.74e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373 228 LVALSVLT-ASLSYMVGMIASFyNTEAVIMAVGITTAV--CFTVviFSMQTR---YDFtscMGVLLVSMV-VLFIFAILC 300
Cdd:cd10430  71 LLGFAFLTgASLGPLLDLVIAI-NPSIIVTAFLGTAVIfaCFSL--AALLAKrreYLY---LGGLLSSALsILLLVSLAN 144

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57165373 301 IFIRNRILEIVYASLGALLFTCFLAVDTQLLLgnKQLSLSPEEYVFAALNLYTDIINIFLYILTI 365
Cdd:cd10430 145 IFGGSKFLFQAELYLGLLVFCGFVLFDTQMII--EKAENGDRDYIWHALDLFVDFVALFRRLLII 207
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 41-140 1.70e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.31  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    41 PYPQPPFQPSPYGQPGYPHGPSPYPQ----GGYPQGPYP-QGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYG 115
Cdd:pfam03154 243 PSPHPPLQPMTQPPPPSQVSPQPLPQpslhGQMPPMPHSlQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322

                          90       100
                  ....*....|....*....|....*.
gi 57165373   116 Q-PQVFPGQDPDSPQHGNYQEEGPPS 140
Cdd:pfam03154 323 QrIHTPPSQSQLQSQQPPREQPLPPA 348
DUF3824 pfam12868
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It ...
 40-126 2.31e-08

Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.


Pssm-ID: 372351 [Multi-domain]  Cd Length: 145  Bit Score: 52.44  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    40 APYPQPPFQPSPYGQPGYPHGPS-PYPQGGYPQGPypQGGYPQGPYPQegYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQ 118
Cdd:pfam12868  59 SPYPPSPAGPYASQGQYYPETNYfPPPPGSTPQPP--VDPQPNAPPPP--YNPADYPPPPGAAPPPQPYQYPPPPGPDPY 134


                  ....*...
gi 57165373   119 VFPGQDPD 126
Cdd:pfam12868 135 APRPRRAD 142
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 44-148 2.98e-08

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 52.73  E-value: 2.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    44 QPPFQPSPYGQ-PGYPHGPSPYPQGGYPQGPyPQGGYPQGPyPQEGYPQGPYPQGG--YPQGPYPQSPFPPNPyGQPQVF 120
Cdd:pfam15240  28 SPSLISEEEGQsQQGGQGPQGPPPGGFPPQP-PASDDPPGP-PPPGGPQQPPPQGGkqKPQGPPPQGGPRPPP-GKPQGP 104

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 57165373   121 PGQD---------PDSPQHGNYQEEGPPSYYDNQDFP 148
Cdd:pfam15240 105 PPQGgnqqqgpppPGKPQGPPPQGGGPPPQGGNQQGP 141
PHA03377 PHA03377
EBNA-3C; Provisional
 40-139 6.52e-08

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 54.67  E-value: 6.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    40 APYP---QPPFQPSPYgqPGYPHG-PSPYPQGGYpQGPYPQGG----YP--QGPYPQEgyPQGP-----------YPQGG 98
Cdd:PHA03377  746 APYSgheEPQAQQAPY--PGYWEPrPPQAPYLGY-QEPQAQGVqvssYPgyAGPWGLR--AQHPryrhswaywsqYPGHG 820

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 57165373    99 YPQGPY-PQSPFPPnPYGQPQVFPGQDPDSPQHGNYQEEGPP 139
Cdd:PHA03377  821 HPQGPWaPRPPHLP-PQWDGSAGHGQDQVSQFPHLQSETGPP 861
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 41-140 1.92e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.23  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    41 PYPQPPFQPSPYGQP----------GYPHGPSPY-PQGGYPQGPYPQGGYPQgPYPQEGYpQGPYPQGGYP--------Q 101
Cdd:pfam03154 213 ATSQPPNQTQSTAAPhtliqqtptlHPQRLPSPHpPLQPMTQPPPPSQVSPQ-PLPQPSL-HGQMPPMPHSlqtgpshmQ 290

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 57165373   102 GPYPQSPFP-PNPYGQPQVFPGQDPDSPQHGNYQEEGPPS 140
Cdd:pfam03154 291 HPVPPQPFPlTPQSSQSQVPPGPSPAAPGQSQQRIHTPPS 330
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 44-125 7.57e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 51.24  E-value: 7.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    44 QPPFQPSPYGQPGYPHGPSP-YPQGGYPQGPYPQGGYPQgpypqegYPQGPYPQGGYPQGPYPqspfPPNPYGQPQVFPG 122
Cdd:PRK10263  770 QPVAPQPQYQQPQQPVAPQPqYQQPQQPVAPQPQYQQPQ-------QPVAPQPQYQQPQQPVA----PQPQYQQPQQPVA 838


                  ...
gi 57165373   123 QDP 125
Cdd:PRK10263  839 PQP 841
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 41-133 4.84e-06

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 47.29  E-value: 4.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    41 PYPQppfQPSPYGQPGYPHGPSPY-PQGGYPQGPYPQGGYPQGPYPQEGYPQ-GPYPQGGYPQG-----PYPQSPFPPNP 113
Cdd:pfam15822 118 PFPE---LPRPYGAPTDPAAAAPSgPWGSMSSGPWAPGMGGQYPAPNMPYPSpGPYPAVPPPQSpgaapPVPWGTVPPGP 194

                          90       100
                  ....*....|....*....|
gi 57165373   114 YGQPQVFPGQDPDSPQHGNY 133
Cdd:pfam15822 195 WGPPAPYPDPTGSYPMPGLY 214
dnaA PRK14086
chromosomal replication initiator protein DnaA;
39-153 5.95e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 48.28  E-value: 5.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   39 GAP---YPQPPFQPSPYGQPGYPHGPSPYPqgGYPQgpYPQGGYPqGPYPQEGYPQGP-YPQGGYPqgpypqspfPPNPY 114
Cdd:PRK14086 115 RRPyegYGGPRADDRPPGLPRQDQLPTARP--AYPA--YQQRPEP-GAWPRAADDYGWqQQRLGFP---------PRAPY 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 57165373  115 GQP-QVFPGQDPDSPQHGNYQEEGPPSYYDnQDFPATNWD 153
Cdd:PRK14086 181 ASPaSYAPEQERDREPYDAGRPEYDQRRRD-YDHPRPDWD 219
PHA03247 PHA03247
large tegument protein UL36; Provisional
 41-100 8.67e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 8.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57165373    41 PYPQPPFQPSPYGQPGYPHGPSPYPQ---GGYPQGPYPQGGYPQGPYPQEGYPQG-PYPQGGYP 100
Cdd:PHA03247 2897 SFALPPDQPERPPQPQAPPPPQPQPQpppPPQPQPPPPPPPRPQPPLAPTTDPAGaGEPSGAVP 2960
PHA03247 PHA03247
large tegument protein UL36; Provisional
 43-140 1.61e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPYGQPGYPHGPSPYPQ-----GGY--PQGPYPQGGYPQGPYPQEGYPQGP------------------YPQG 97
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPPPPPGPPPpslplGGSvaPGGDVRRRPPSRSPAAKPAAPARPpvrrlarpavsrstesfaLPPD 2903

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 57165373    98 GYPQGPYPQSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPS 140
Cdd:PHA03247 2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 43-106 1.69e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 1.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57165373    43 PQPPFQPSP-YGQPGYPHGPSP-YPQGGYPQGPYPQGGYPQGPYPqegyPQGPYPQGGYPQGPYPQ 106
Cdd:PRK10263  781 PQQPVAPQPqYQQPQQPVAPQPqYQQPQQPVAPQPQYQQPQQPVA----PQPQYQQPQQPVAPQPQ 842
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 40-134 2.96e-05

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 46.22  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    40 APYPQPPFQPSPYGQPGYPHGP---SPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQ 116
Cdd:PTZ00395  392 AAYSNAAQSNAAQSNAGFSNAGysnPGNSNPGYNNAPNSNTPYNNPPNSNTPYSNPPNSNPPYSNLPYSNTPYSNAPLSN 471

                          90
                  ....*....|....*...
gi 57165373   117 PQVFPGQDPDSPQHGNYQ 134
Cdd:PTZ00395  472 APPSSAKDHHSAYHAAYQ 489
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 63-160 3.07e-05

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 46.22  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    63 PYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQvFPGQDPDSPQHGNYQEEGPPSY- 141
Cdd:PTZ00395  373 PDARGAWAGGPHSNASYNCAAYSNAAQSNAAQSNAGFSNAGYSNPGNSNPGYNNAP-NSNTPYNNPPNSNTPYSNPPNSn 451

                          90       100
                  ....*....|....*....|.
gi 57165373   142 --YDNQDFPATNWDDKSIRQA 160
Cdd:PTZ00395  452 ppYSNLPYSNTPYSNAPLSNA 472
PHA03378 PHA03378
EBNA-3B; Provisional
 40-140 4.78e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 4.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   40 APYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQ-SPFPPNPYGQPQ 118
Cdd:PHA03378 702 TPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAaAPGAPTPQPPPQ 781

                         90       100
                 ....*....|....*....|....
gi 57165373  119 VFPG--QDPDSPQHGNYQEEGPPS 140
Cdd:PHA03378 782 APPApqQRPRGAPTPQPPPQAGPT 805
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 37-142 5.85e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    37 YPGAPYPQPPFQPSPYGQPGYPHGPSPYPQGGY-PQGPYPQGGYPQGPYPQEG-YPQGPYPQggyPQGPYPQSPFPPNPY 114
Cdd:PRK10263  402 QPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYaPAPEQPVAGNAWQAEEQQStFAPQSTYQ---TEQTYQQPAAQEPLY 478

                          90       100       110
                  ....*....|....*....|....*....|
gi 57165373   115 GQPQVFPGQDPDSPQHG--NYQEEGPPSYY 142
Cdd:PRK10263  479 QQPQPVEQQPVVEPEPVveETKPARPPLYY 508
PHA03247 PHA03247
large tegument protein UL36; Provisional
 44-138 5.90e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    44 QPPFQPSPYGQPGYPHGPS---PYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPfpPNPYGQPQVF 120
Cdd:PHA03247 2865 RPPSRSPAAKPAAPARPPVrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP--PPPPPRPQPP 2942

                          90
                  ....*....|....*...
gi 57165373   121 PGQDPDSPQHGNYQEEGP 138
Cdd:PHA03247 2943 LAPTTDPAGAGEPSGAVP 2960
DUF3824 pfam12868
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It ...
 40-98 7.80e-05

Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.


Pssm-ID: 372351 [Multi-domain]  Cd Length: 145  Bit Score: 42.42  E-value: 7.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 57165373    40 APYPQPPFQPSPYGQPGyPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGG 98
Cdd:pfam12868  87 GSTPQPPVDPQPNAPPP-PYNPADYPPPPGAAPPPQPYQYPPPPGPDPYAPRPRRADEN 144
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 32-145 8.97e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 44.64  E-value: 8.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    32 YAQPPypgAPYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGG------YPQGPYPQEGYPQGPYPQGGYPQGPYP 105
Cdd:pfam09770 218 PAQPP---AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHpvtilqRPQSPQPDPAQPSIQPQAQQFHQQPPP 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 57165373   106 QSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQ 145
Cdd:pfam09770 295 VPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHR 334
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 40-151 9.40e-05

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 44.68  E-value: 9.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    40 APYPQPPFQPSPYGQPGYPHgpSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQV 119
Cdd:PTZ00395  402 AAQSNAGFSNAGYSNPGNSN--PGYNNAPNSNTPYNNPPNSNTPYSNPPNSNPPYSNLPYSNTPYSNAPLSNAPPSSAKD 479

                          90       100       110
                  ....*....|....*....|....*....|..
gi 57165373   120 FPGQDPDSPQHGNYQEEGPPSYYDNQdfPATN 151
Cdd:PTZ00395  480 HHSAYHAAYQHRAANQPAANLPTANQ--PAAN 509
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 75-158 1.03e-04

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 42.33  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    75 PQGGYPQGPYPQEG-YPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPATNWD 153
Cdd:pfam15240  30 SLISEEEGQSQQGGqGPQGPPPGGFPPQPPASDDPPGPPPPGGPQQPPPQGGKQKPQGPPPQGGPRPPPGKPQGPPPQGG 109


                  ....*
gi 57165373   154 DKSIR 158
Cdd:pfam15240 110 NQQQG 114
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 54-163 1.12e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    54 QPGYPHGPSPYPQGGYPQGPYPQGGYPQGPY-PQEGY--PQGPYPQGgyPQGPYPQSPFPPNP-YGQPqvfpgQDPDSPQ 129
Cdd:PRK10263  742 EPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVaPQPQYqqPQQPVAPQ--PQYQQPQQPVAPQPqYQQP-----QQPVAPQ 814

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 57165373   130 HGNYQEEGP----PSYYDNQDFPATNWDDKSIRQAFIR 163
Cdd:PRK10263  815 PQYQQPQQPvapqPQYQQPQQPVAPQPQDTLLHPLLMR 852
DUF3824 pfam12868
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It ...
 57-145 1.29e-04

Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.


Pssm-ID: 372351 [Multi-domain]  Cd Length: 145  Bit Score: 41.65  E-value: 1.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    57 YPHGPSPYPQGGYPQGPYPQGgyPQGPYPQEG--YPQG---PYPQGGYPQG---PYPQSPFPP-NP--YGQPqvfPGQDP 125
Cdd:pfam12868  44 YEDDYRDYYEDPYSPSPYPPS--PAGPYASQGqyYPETnyfPPPPGSTPQPpvdPQPNAPPPPyNPadYPPP---PGAAP 118

                          90       100
                  ....*....|....*....|
gi 57165373   126 DSPQHGNYQEEGPPSYYDNQ 145
Cdd:pfam12868 119 PPQPYQYPPPPGPDPYAPRP 138
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 39-141 2.69e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    39 GAPYPQPPFQPSPYGQPGYPHGPSPYPQGGYP-QGPYP---------QGGYPQGPYPQEGY----------PQGPYPQGG 98
Cdd:PRK10263  365 GPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPlQQPVQpqqpyyapaAEQPAQQPYYAPAPeqpaqqpyyaPAPEQPVAG 444

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 57165373    99 YP-QGPYPQSPFPPNPYGQP-QVFPGQDPDSPQHGNYQEEGPPSY 141
Cdd:PRK10263  445 NAwQAEEQQSTFAPQSTYQTeQTYQQPAAQEPLYQQPQPVEQQPV 489
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 45-136 3.67e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 42.69  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    45 PPFQPspyGQPGYPHGPSPYP--------------QGGYPQGPYPQG-GYPQGPYPqegyPQGPYPQGGYPQGPYPQ-SP 108
Cdd:pfam09606 363 NPMQR---GQPGMMSSPSPVPgqqvrqvtpnqfmrQSPQPSVPSPQGpGSQPPQSH----PGGMIPSPALIPSPSPQmSQ 435

                          90       100       110
                  ....*....|....*....|....*....|....
gi 57165373   109 FPPNPYGQPQVFPGQDPDSPQHG------NYQEE 136
Cdd:pfam09606 436 QPAQQRTIGQDSPGGSLNTPGQSavnsplNPQEE 469
KLF1_N cd21581
N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as ...
 42-111 3.69e-04

N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as Krueppel-like factor 1 or Erythroid Kruppel-like Factor/EKLF) was the first Kruppel-like factor discovered. It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains. EKLF ablation in mouse embryos produces a lethal anemic phenotype, causing death by embryonic day 14, and natural mutations lead to beta+ thalassemia in humans. However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, suggesting other factors may be involved. KLF1 functions as a transcriptional activator. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF1, which is related to the N-terminal domains of KLF2 and KLF4.


Pssm-ID: 409227 [Multi-domain]  Cd Length: 278  Bit Score: 41.95  E-value: 3.69e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57165373  42 YPQ-----PPFQPSPYGQPGYPHGPSPYPQggyPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPP 111
Cdd:cd21581 187 YPQqhpsvVAFPDSRFGPLSGPQALTPDPQ---HYGYFQLFRHNAALFPDYAHSPGPGHLPLGQQPLLPDPPLPP 258
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
39-78 5.12e-04

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 41.16  E-value: 5.12e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 57165373  39 GAPYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGG 78
Cdd:COG3416 105 PGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSGGG 144
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 39-147 6.23e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.59  E-value: 6.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373  39 GAPYP-QPPFQPSPYGQPGYPHG--PSPYPQGGYPQGPYPQGGYPQGPyPQEGYPQGPY-PQGGYPQ--GPYPQSPFPPN 112
Cdd:COG5180 327 GTPRPgQPTERPAGVPEAASDAGqpPSAYPPAEEAVPGKPLEQGAPRP-GSSGGDGAPFqPPNGAPQpgLGRRGAPGPPM 405

                        90       100       110
                ....*....|....*....|....*....|....*
gi 57165373 113 PYGQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDF 147
Cdd:COG5180 406 GAGDLVQAALDGGGRETASLGGAAGGAGQGPKADF 440
dnaA PRK14086
chromosomal replication initiator protein DnaA;
39-140 6.94e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.73  E-value: 6.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   39 GAPYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQggyPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNP-YGQP 117
Cdd:PRK14086 145 AYPAYQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYAS---PASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPdWDRP 221

                         90       100
                 ....*....|....*....|....
gi 57165373  118 QVFPGQDPD-SPQHGNYQEEGPPS 140
Cdd:PRK14086 222 RRDRTDRPEpPPGAGHVHRGGPGP 245
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 43-149 7.02e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPyPQGGYPQGPYPQEGYPQ-GPY------PQGGYPQGPYPQSPFPP--NP 113
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVP-PQGSPATSQPPNQTQSTaAPHtliqqtPTLHPQRLPSPHPPLQPmtQP 255

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 57165373   114 YGQPQVFPGQDPDSPQHGnyqeEGPPSYYDNQDFPA 149
Cdd:pfam03154 256 PPPSQVSPQPLPQPSLHG----QMPPMPHSLQTGPS 287
YppG pfam14179
YppG-like protein; The YppG-like protein family includes the B. subtilis YppG protein, which ...
 43-97 8.19e-04

YppG-like protein; The YppG-like protein family includes the B. subtilis YppG protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.


Pssm-ID: 372950 [Multi-domain]  Cd Length: 101  Bit Score: 38.25  E-value: 8.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 57165373    43 PQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPqggyPQGPYPQEGyPQGPYPQG 97
Cdd:pfam14179   7 PYPYFSQQVYQQPVQPQYPPFAPQQYMPQPPMP----YMNPYPKQQ-PQQQQPSQ 56
PHA03378 PHA03378
EBNA-3B; Provisional
 39-116 8.86e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 8.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   39 GAPYPQPPFQPSPYG--QPGYPHGPSPYPQGGyPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQ 116
Cdd:PHA03378 739 AAPGRARPPAAAPGRarPPAAAPGRARPPAAA-PGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQ 817
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 41-159 1.09e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    41 PYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQ-GPYPQGGYPQGPYPQEGYP-----QGPYPQGGYPQGPYPQSPFPPNPY 114
Cdd:PRK10263  342 QTPPVASVDVPPAQPTVAWQPVPGPQTGEPViAPAPEGYPQQSQYAQPAVQyneplQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 57165373   115 GQPQVFPGQDPDSPQHGNYQEEGPPSYYDNQDFPatnWDDKSIRQ 159
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQST---FAPQSTYQ 463
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 43-113 1.25e-03

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 38.88  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQP-------SPYGQPGYPHGPSP----YPQGGYPQGPYPqgGYPQGPYPqeGYPQGPYPqgGYPQGPYPQSPFPP 111
Cdd:pfam02389  13 PQEPCVPttkepchSKVPEPCNPKVPEPccpkVPEPCCPKVPEP--CCPKVPEP--CCPKVPEP--CYPKVPEPCSPKVP 86


                  ..
gi 57165373   112 NP 113
Cdd:pfam02389  87 EP 88
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 39-136 1.47e-03

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 38.50  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    39 GAPYPQPPFQPSP----YGQPGYPHGPSP----YPQGGYPQGPYPqgGYPQGPYPqeGYPQGPYPqgGYPQGPYPQSPFP 110
Cdd:pfam02389  36 KVPEPCCPKVPEPccpkVPEPCCPKVPEPccpkVPEPCYPKVPEP--CSPKVPEP--CHPKAPEP--CHPKVPEPCYPKA 109

                          90       100
                  ....*....|....*....|....*.
gi 57165373   111 PNPyGQPQVfPGQDPDSPQHGNYQEE 136
Cdd:pfam02389 110 PEP-CQPKV-PEPCPSTVTPGPAQQK 133
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 43-139 1.50e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    43 PQPPFQPSPYGQPGYPhgPSPYPQGG------YPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYP----QGPYPQSPFPPN 112
Cdd:pfam09770 238 PQIQQQQQPQQQPQQP--QQHPGQGHpvtilqRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPtqilQNPNRLSAARVG 315

                          90       100
                  ....*....|....*....|....*..
gi 57165373   113 PYGQPQVFPGQDPDSPQHGNYQEEGPP 139
Cdd:pfam09770 316 YPQNPQPGVQPAPAHQAHRQQGSFGRQ 342
PHA03247 PHA03247
large tegument protein UL36; Provisional
 41-128 1.56e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    41 PYPQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVF 120
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPP 2648


                  ....*...
gi 57165373   121 PGQDPDSP 128
Cdd:PHA03247 2649 PERPRDDP 2656
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 41-123 1.73e-03

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 38.11  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    41 PYPQPPFQPSP----YGQPGYPHGPSP----YPQGGYPQGPYPqgGYPQGPYPqeGYPQGPYPqgGYPQGPYPQSPFPPN 112
Cdd:pfam02389  30 PEPCNPKVPEPccpkVPEPCCPKVPEPccpkVPEPCCPKVPEP--CYPKVPEP--CSPKVPEP--CHPKAPEPCHPKVPE 103

                          90
                  ....*....|..
gi 57165373   113 PyGQPQV-FPGQ 123
Cdd:pfam02389 104 P-CYPKApEPCQ 114
PHA03247 PHA03247
large tegument protein UL36; Provisional
 40-139 2.37e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    40 APYPQPPFQPSPYGQPGYPHGPSPYPQG-----GYPQGPYPQGGY--PQGPYPQEGYPQGPYPQGGYPQGP------YPQ 106
Cdd:PHA03247 2811 VLAPAAALPPAASPAGPLPPPTSAQPTApppppGPPPPSLPLGGSvaPGGDVRRRPPSRSPAAKPAAPARPpvrrlaRPA 2890

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 57165373   107 SPFPPNPYGQPQVFPGQ--DPDSPQHGNYQEEGPP 139
Cdd:PHA03247 2891 VSRSTESFALPPDQPERppQPQAPPPPQPQPQPPP 2925
PHA03369 PHA03369
capsid maturational protease; Provisional
 39-130 2.53e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 39.98  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   39 GAPyPQPPFQPSPYGQPGYPHG-PSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQP 117
Cdd:PHA03369 369 IAA-PQTHTGPADRQRPQRPDGiPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTSYGPEPVGPVPPQPTNPYVMP 447

                         90
                 ....*....|....*...
gi 57165373  118 -----QVFPGQDPDSPQH 130
Cdd:PHA03369 448 ismanMVYPGHPQEHGHE 465
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 43-160 2.56e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   43 PQPPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSPFPPNPYGQPQVF-- 120
Cdd:PRK07764 675 GAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAga 754

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 57165373  121 PGQDPDSPQHGNYQEEGPPSYYDNQDFP-------ATNWDDKSIRQA 160
Cdd:PRK07764 755 PAQPPPPPAPAPAAAPAAAPPPSPPSEEeemaeddAPSMDDEDRRDA 801
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 39-140 2.86e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    39 GAPYPQPPFQPSPYGQPGYPhgPSPYPQggYPQGPYPQGGYPqgPYPQEGYPQ-------GPYPQGGYPQGPYPQSPFPP 111
Cdd:TIGR01628 401 YGQGPQQQFNGQPLGWPRMS--MMPTPM--GPGGPLRPNGLA--PMNAVRAPSrnaqnaaQKPPMQPVMYPPNYQSLPLS 474

                          90       100
                  ....*....|....*....|....*....
gi 57165373   112 NPYGQPQVFPGQDPDSPQHGNYQEEGPPS 140
Cdd:TIGR01628 475 QDLPQPQSTASQGGQNKKLAQVLASATPQ 503
dnaA PRK14086
chromosomal replication initiator protein DnaA;
42-146 3.28e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.42  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   42 YPQPPFQPSPYG----------QPGYPHgpspYPQGGYPqGPYPQGGYPQGP-YPQEGYPQG-PYPQggyPQGPYPQSPF 109
Cdd:PRK14086 121 YGGPRADDRPPGlprqdqlptaRPAYPA----YQQRPEP-GAWPRAADDYGWqQQRLGFPPRaPYAS---PASYAPEQER 192

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 57165373  110 PPNPYGQpqvfpgQDPDSPQH-GNYQEEGPPSYYDNQD 146
Cdd:PRK14086 193 DREPYDA------GRPEYDQRrRDYDHPRPDWDRPRRD 224
SSDP pfam04503
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA ...
 38-142 4.38e-03

Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.


Pssm-ID: 461334 [Multi-domain]  Cd Length: 293  Bit Score: 38.40  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    38 PGAPYPqPPFQPSPYGQPGYPHGPSPYPQggyPQGPYPQGGYPQGPYPQEGYPQGPYP------QGGYPQGPYPQSPFPP 111
Cdd:pfam04503  35 PGGPMP-PGFFQSPPSHPSSQPSPHAQPP---PHNPATMMGPHSQPFMGPRYPGGPRPsvrmpqQGNDFNGPPGQQPMMP 110

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 57165373   112 N------PYGQPQVFPGQDPDSPQHGNYQEEGPPSYY 142
Cdd:pfam04503 111 NsmdptrPGGHPNMGGPMQRMNPPRGPGMGPMGPQSY 147
KLF1_2_4_N cd21972
N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel ...
 40-131 5.20e-03

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.


Pssm-ID: 409230 [Multi-domain]  Cd Length: 194  Bit Score: 37.66  E-value: 5.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373  40 APYPQPPFQPSPYGQPGYPHGPSPYP-QGGYPQGPYPQGGY-------PQGPYP-QEGYPQGPYPQGGYPQGPYPQSPFP 110
Cdd:cd21972  43 DPAYPPPESPESCSTVYDSDGCHPTPnAYCGPNGPGLPGHFllagnspNLGPKIkTENQEQACMPVAGYSGHYGPREPQR 122

                        90       100
                ....*....|....*....|..
gi 57165373 111 PNP-YGQPQVFPGQDPDSPQHG 131
Cdd:cd21972 123 VPPaPPPPQYAGHFQYHGHFNM 144
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 39-157 6.78e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 38.60  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373   39 GAPYPQ---PPFQPSPYGQPGyPHGP----SPYPQGGYPQ-GPYPQGGYPQ-GPYPQEGYPQ-GPYPQGGYPQ-GPYPQS 107
Cdd:NF033839 381 ETPKPEvkpQPEKPKPEVKPQ-PEKPkpevKPQPEKPKPEvKPQPEKPKPEvKPQPEKPKPEvKPQPEKPKPEvKPQPET 459

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57165373  108 PFP--------PNPYGQPQV-FPGQDPDSPQH--------GNYQEEGPPSYYDNQDFPATNWDDKSI 157
Cdd:NF033839 460 PKPevkpqpekPKPEVKPQPeKPKPDNSKPQAddkkpstpNNLSKDKQPSNQASTNEKATNKPKKSL 526
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 40-121 8.24e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 38.09  E-value: 8.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373    40 APYPQPPFQPSPYGQPGYPHGPSPY----PQGGYPQGPYPQGG-----YPQGPYPQEGYP-------------QGPYPQG 97
Cdd:pfam09770 240 IQQQQQPQQQPQQPQQHPGQGHPVTilqrPQSPQPDPAQPSIQpqaqqFHQQPPPVPVQPtqilqnpnrlsaaRVGYPQN 319

                          90       100
                  ....*....|....*....|....*
gi 57165373    98 G-YPQGPYPQSPFPPNPYGQPQVFP 121
Cdd:pfam09770 320 PqPGVQPAPAHQAHRQQGSFGRQAP 344
KLF4_N cd21582
N-terminal domain of Kruppel-like factor 4; Kruppel-like factor 4 (KLF4; also known as ...
 39-140 9.82e-03

N-terminal domain of Kruppel-like factor 4; Kruppel-like factor 4 (KLF4; also known as Krueppel-like factor 4 or gut-enriched Kruppel-like factor/GKLF) is a protein that, in humans, is encoded by the KLF4 gene. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer, gastric cancer, esophageal squamous cell carcinoma, intestinal cancer, prostate cancer, bladder cancer and lung cancer. It may act as a tumor promoter where increased KLF4 expression has been reported, such as in oral squamous cell carcinoma and in primary breast ductal carcinoma. KLF4 is one of four key factors that are essential for inducing pluripotent stem cells. KLF4 is highly expressed in non-dividing cells and its overexpression induces cell cycle arrest. KLF proteins KLF1, KLF2, KLF4, KLF5, KLF6, and KLF7 are transcriptional activators. KLF4 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF4, which is related to the N-terminal domains of KLF1 and KLF2.


Pssm-ID: 409228 [Multi-domain]  Cd Length: 335  Bit Score: 37.75  E-value: 9.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57165373  39 GAPYPQPPF------QPSP----YGQPGYPHGPSPyPQGGYPQGPYPQGGYPQGPYPQEGYPQGPYPQGGYPQGPYPQSP 108
Cdd:cd21582 196 VAPSSSLPFmcprikQENPstctISRPMDGHLGGN-SQHGFSQRAPLPSRTTPSGGPGGGNSSTAESLMSRDHHPSSQVL 274

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 57165373 109 FPPNP-----YGQPQVFPGQDPDSPQHGNYQEEGPPS 140
Cdd:cd21582 275 SHPPLplpqgYHPSPGYPPFPPPPSQPQQYQELMSPG 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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