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Conserved domains on  [gi|47576871|ref|NP_001000551|]
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olfactory receptor Olr218 [Rattus norvegicus]

Protein Classification

olfactory receptor family 2 protein( domain architecture ID 11607568)

olfactory receptor family 2 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-301 5.75e-146

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320543  Cd Length: 277  Bit Score: 411.56  E-value: 5.75e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
 
Name Accession Description Interval E-value
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-301 5.75e-146

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 411.56  E-value: 5.75e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
33-305 1.94e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 134.55  E-value: 1.94e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871    33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871   113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871   193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQ-- 270
Cdd:pfam13853 163 KVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPll 242
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 47576871   271 DNITSVFYTIVTPALNPLIYSLRNKEVIGALRRVL 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-301 5.75e-146

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 411.56  E-value: 5.75e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15421 242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
26-301 4.28e-119

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 343.67  E-value: 4.28e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15225 242 YSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-294 2.37e-109

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 318.66  E-value: 2.37e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
35-294 2.94e-107

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 313.29  E-value: 2.94e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  35 YILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDLL 114
Cdd:cd15230  11 YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 115 LAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTSQ 194
Cdd:cd15230  91 LAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 195 YELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNIT 274
Cdd:cd15230 171 NELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKVV 250
                       250       260
                ....*....|....*....|
gi 47576871 275 SVFYTIVTPALNPLIYSLRN 294
Cdd:cd15230 251 SVFYTVVIPMLNPLIYSLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
26-294 3.32e-105

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 308.05  E-value: 3.32e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15237   2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15237 162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15237 242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
12-305 9.94e-100

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 295.04  E-value: 9.94e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  12 FILVGILNGSSSPELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENT 91
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  92 ISFGGCALQMALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMS 171
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 172 QEIRHLLCEILPLLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMF 251
Cdd:cd15943 162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576871 252 YGAATFMYVLPSSLHSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRRVL 305
Cdd:cd15943 242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
26-301 1.91e-98

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 291.43  E-value: 1.91e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15235 243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-297 1.33e-97

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 289.61  E-value: 1.33e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  12 FILVGILNGSSSPELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  92 ISFGGCALQMALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMS 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 172 QEIRHLLCEILPLLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47576871 252 YGAATFMYVLPSSLHSTKQDNITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
34-303 5.51e-97

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 287.67  E-value: 5.51e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15419  10 IYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15419  90 LLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:cd15419 170 INELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSKV 249
                       250       260       270
                ....*....|....*....|....*....|
gi 47576871 274 TSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15419 250 VSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
34-294 1.36e-96

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 286.04  E-value: 1.36e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15431  10 VYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHtVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15431  90 LLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIP-VLTMPLHFCGPNVINHFFCEVQALLKLACSDTS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:cd15431 169 LNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDKI 248
                       250       260
                ....*....|....*....|.
gi 47576871 274 TSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15431 249 ISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
26-301 1.48e-96

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 286.53  E-value: 1.48e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15420 242 NSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
25-294 2.78e-96

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 285.28  E-value: 2.78e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  25 ELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALA 104
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPL 184
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 185 LKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSS 264
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576871 265 LHSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15918 241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
26-301 9.97e-96

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 284.16  E-value: 9.97e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15231   2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15231  82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15231 162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15231 242 YSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
34-294 1.55e-95

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 283.58  E-value: 1.55e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15227  10 IYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15227  90 LLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:cd15227 170 LNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLL 249
                       250       260
                ....*....|....*....|.
gi 47576871 274 TSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15227 250 LSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
25-301 2.27e-95

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 283.50  E-value: 2.27e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  25 ELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALA 104
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPL 184
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 185 LKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSS 264
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576871 265 LHSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15434 241 SVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
34-303 1.27e-93

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 279.20  E-value: 1.27e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15411  10 IYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15411  90 LLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:cd15411 170 VNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKV 249
                       250       260       270
                ....*....|....*....|....*....|
gi 47576871 274 TSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15411 250 ASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-305 2.36e-93

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 278.77  E-value: 2.36e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  12 FILVGIlngSSSPEL---LCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLK 88
Cdd:cd15410   1 FILLGF---TDYPELqvpLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAE 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  89 ENTISFGGCALQMALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPF 168
Cdd:cd15410  78 DKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 169 CMSQEIRHLLCEILPLLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVV 248
Cdd:cd15410 158 CGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAI 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576871 249 GMFYGAATFMYVLPSSLHSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRRVL 305
Cdd:cd15410 238 TIFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
33-305 3.64e-93

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 278.48  E-value: 3.64e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15406  18 GIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAEC 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15406  98 YMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSST 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDN 272
Cdd:cd15406 178 YINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEK 257
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576871 273 ITSVFYTIVTPALNPLIYSLRNKEVIGALRRVL 305
Cdd:cd15406 258 VSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
26-294 5.92e-93

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 277.06  E-value: 5.92e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15912 242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
26-303 1.65e-92

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 276.06  E-value: 1.65e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15417 242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
35-301 1.28e-91

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 273.70  E-value: 1.28e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  35 YILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDLL 114
Cdd:cd15229  11 YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 115 LAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTSQ 194
Cdd:cd15229  91 LSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 195 YELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNIT 274
Cdd:cd15229 171 NKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVF 250
                       250       260
                ....*....|....*....|....*..
gi 47576871 275 SVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15229 251 SIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
27-294 2.46e-91

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 272.96  E-value: 2.46e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  27 LCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALM 106
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 107 LGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLK 186
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 187 LSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLH 266
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242
                       250       260
                ....*....|....*....|....*...
gi 47576871 267 STKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15947 243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
34-303 2.54e-91

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 273.04  E-value: 2.54e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15413  10 IYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15413  90 LLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:cd15413 170 EKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKM 249
                       250       260       270
                ....*....|....*....|....*....|
gi 47576871 274 TSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15413 250 ASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-303 4.28e-90

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 270.46  E-value: 4.28e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  12 FILVGILNGSSSPELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  92 ISFGGCALQMALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMS 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 172 QEIRHLLCEILPLLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576871 252 YGAATFMYVLPSSLHSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
33-301 8.63e-90

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 269.27  E-value: 8.63e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15429   9 VMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15429  89 ILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDN 272
Cdd:cd15429 169 SLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEK 248
                       250       260
                ....*....|....*....|....*....
gi 47576871 273 ITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15429 249 MISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
26-294 1.28e-88

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 266.16  E-value: 1.28e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15430   2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15430  82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15430 242 NAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
26-294 1.69e-88

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 265.66  E-value: 1.69e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15232 242 YSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
33-303 1.93e-88

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 265.81  E-value: 1.93e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15409   9 AIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15409  89 FLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDP 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDN 272
Cdd:cd15409 169 SINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDM 248
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576871 273 ITSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15409 249 MDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
27-303 2.62e-87

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 263.07  E-value: 2.62e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  27 LCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALM 106
Cdd:cd15416   3 LFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAAT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 107 LGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLK 186
Cdd:cd15416  83 FGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 187 LSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLH 266
Cdd:cd15416 163 LSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSY 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576871 267 STKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15416 243 SMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
33-294 2.32e-85

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 257.80  E-value: 2.32e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15911   9 VIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15911  89 YLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDN 272
Cdd:cd15911 169 SLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNK 248
                       250       260
                ....*....|....*....|..
gi 47576871 273 ITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15911 249 VFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-305 7.91e-85

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 257.41  E-value: 7.91e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  12 FILVGILNGSSSPELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  92 ISFGGCALQMALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMS 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 172 QEIRHLLCEILPLLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576871 252 YGAATFMYVLPSSLHSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRRVL 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
35-307 2.58e-84

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 255.43  E-value: 2.58e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  35 YILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDLL 114
Cdd:cd15414  11 YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 115 LAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTSQ 194
Cdd:cd15414  91 LASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 195 YELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNIT 274
Cdd:cd15414 171 NKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVV 250
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576871 275 SVFYTIVTPALNPLIYSLRNKEVIGALRRVLGR 307
Cdd:cd15414 251 SVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
26-294 4.83e-84

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 254.13  E-value: 4.83e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15224   2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15224  82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15224 162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAI 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15224 242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
26-301 1.70e-82

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 250.81  E-value: 1.70e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15424  82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15424 162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15424 242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
30-303 2.61e-82

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 250.42  E-value: 2.61e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGS 109
Cdd:cd15407   6 IFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFAT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 110 AEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSC 189
Cdd:cd15407  86 VENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 190 VDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTK 269
Cdd:cd15407 166 SDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMD 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576871 270 QDNITSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15407 246 TDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
33-301 8.10e-82

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 248.87  E-value: 8.10e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15405   9 GIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15405  89 YVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTST 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDN 272
Cdd:cd15405 169 YVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGK 248
                       250       260
                ....*....|....*....|....*....
gi 47576871 273 ITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15405 249 VSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
26-301 9.99e-82

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 248.65  E-value: 9.99e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
30-303 1.72e-81

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 248.10  E-value: 1.72e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGS 109
Cdd:cd15415   6 LFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 110 AEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSC 189
Cdd:cd15415  86 TEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 190 VDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTK 269
Cdd:cd15415 166 SDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLE 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576871 270 QDNITSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15415 246 QEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
26-303 1.32e-80

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 245.77  E-value: 1.32e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15412 162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRR 303
Cdd:cd15412 242 ESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
33-294 1.90e-80

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 245.29  E-value: 1.90e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15915   9 LLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15915  89 MLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMP-SNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQD 271
Cdd:cd15915 169 SLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQD 248
                       250       260
                ....*....|....*....|...
gi 47576871 272 NITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15915 249 RIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
26-301 2.86e-79

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 242.38  E-value: 2.86e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15432   2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15432  82 GLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15432 162 KLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15432 242 SSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
34-301 7.92e-78

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 238.92  E-value: 7.92e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15428  10 IYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15428  90 LLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:cd15428 170 QAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKM 249
                       250       260
                ....*....|....*....|....*...
gi 47576871 274 TSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15428 250 ISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
26-294 1.78e-77

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 237.49  E-value: 1.78e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMV-----YVTGVTFLLLplsaiVTSYTLILSTVLHMPSnEGKKKALVTCLSHLMVVGMFYGAATFMYV 260
Cdd:cd15226 162 KLACTDTYVLELMVvansgLISLVCFLLL-----LISYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGPCIFIYV 235
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576871 261 LPSSlhSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15226 236 WPFS--TFPVDKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
26-304 1.21e-76

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 235.83  E-value: 1.21e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15418   3 ILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15418  83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15418 163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSS 242
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGALRRV 304
Cdd:cd15418 243 HTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
26-294 1.52e-75

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 232.75  E-value: 1.52e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15946 242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
26-294 1.72e-74

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 229.90  E-value: 1.72e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15913 242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
34-294 1.96e-74

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 229.79  E-value: 1.96e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15939  10 IYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15939  90 LLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTvLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTkqDNI 273
Cdd:cd15939 170 VIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPI--DKV 246
                       250       260
                ....*....|....*....|.
gi 47576871 274 TSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15939 247 VAVFYTIITPMLNPLIYTLRN 267
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
29-301 4.38e-72

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 224.26  E-value: 4.38e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLG 108
Cdd:cd15236   5 ALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 109 SAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLS 188
Cdd:cd15236  85 CLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 189 CVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHST 268
Cdd:cd15236 165 CSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSS 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576871 269 KQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15236 245 DKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
25-301 1.22e-71

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 223.13  E-value: 1.22e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  25 ELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALA 104
Cdd:cd15433   1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPL 184
Cdd:cd15433  81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 185 LKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSS 264
Cdd:cd15433 161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576871 265 LHSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15433 241 RYSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
26-294 8.94e-69

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 215.38  E-value: 8.94e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMpSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSl 265
Cdd:cd15940 162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST- 239
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 hSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15940 240 -SFSEDKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
26-301 2.29e-68

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 214.62  E-value: 2.29e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKE-NTISFGGCALQMALA 104
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPL 184
Cdd:cd15916  82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 185 LKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSS 264
Cdd:cd15916 162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576871 265 lhSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15916 242 --KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
33-301 6.10e-67

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 210.75  E-value: 6.10e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15228   9 AFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15228  89 LLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYElMVYVTGVTFLLLP-LSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSlhSTKQD 271
Cdd:cd15228 169 SIAE-TVSFTNVGLVPLTcFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP--SPVLV 245
                       250       260       270
                ....*....|....*....|....*....|
gi 47576871 272 NITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15228 246 TPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
34-294 2.95e-66

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 208.76  E-value: 2.95e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15914  10 IYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15914  90 LLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:cd15914 170 LNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRA 249
                       250       260
                ....*....|....*....|.
gi 47576871 274 TSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15914 250 IAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
26-301 2.72e-65

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 206.57  E-value: 2.72e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15233 242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
34-301 6.23e-65

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 205.74  E-value: 6.23e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15942  10 VYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15942  90 LYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTA 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTkqDNI 273
Cdd:cd15942 170 FNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPL--DGV 247
                       250       260
                ....*....|....*....|....*...
gi 47576871 274 TSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15942 248 VAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
33-294 7.49e-64

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 202.56  E-value: 7.49e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15936   9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15936  89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYE-LMVYVTGVTFLLLPLSAIVtSYTLILsTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTkqD 271
Cdd:cd15936 169 FLLElLMVSNSGLVTLLIFFILLI-SYTVIL-VKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM--D 244
                       250       260
                ....*....|....*....|...
gi 47576871 272 NITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15936 245 KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
26-294 5.00e-60

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 192.78  E-value: 5.00e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15938   2 LLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15938  82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVlhmPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSL 265
Cdd:cd15938 162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTkqDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15938 239 FPV--DKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
26-301 3.57e-59

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 190.83  E-value: 3.57e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLH-VPMYFLLRQLSLIDLLFTSVVTPKAVMDFL-LKENTISFGGCALQMAL 103
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHgLPMYHFLGHLSFLDACLSSVTVPKVLAGLLtLSGRTISFEGCVVQLYA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 104 ALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILP 183
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 184 LLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPS 263
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576871 264 SLHSTkqDNITSVFYTIVTPALNPLIYSLRNKEVIGAL 301
Cdd:cd15941 242 SSQAG--AGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
26-294 1.15e-57

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 186.89  E-value: 1.15e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNgpLLLVITVDARLHV---PMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMA 102
Cdd:cd15935   2 LLFVLVLACYAAILLGN--LLIVVTVHADPHLlqsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 103 LALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEIL 182
Cdd:cd15935  80 FLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 183 PLLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTvLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLP 262
Cdd:cd15935 160 QVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRP 238
                       250       260       270
                ....*....|....*....|....*....|..
gi 47576871 263 SSlhSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15935 239 FS--SSSVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
26-294 1.20e-55

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 181.47  E-value: 1.20e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLL 185
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTvLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPssL 265
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP--F 238
                       250       260
                ....*....|....*....|....*....
gi 47576871 266 HSTKQDNITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd15937 239 RSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
34-297 2.57e-52

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 173.25  E-value: 2.57e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15223  10 LYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPT----VCWFIVSTSWIMASLTavghTVYTMHFPFCMSQEIRHLLCEILPLLKLSC 189
Cdd:cd15223  90 ILLVMALDRYVAICKPLRYPSIITKSfilkLVLFALIRSGLLVLPI----VVLASQLSYCSSNVIEHCYCDHMALVSLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 190 VDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTK 269
Cdd:cd15223 166 GDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIP 245
                       250       260       270
                ....*....|....*....|....*....|
gi 47576871 270 QD--NITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15223 246 PDvhVLLSVLYILIPPALNPIIYGVRTKEI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
33-297 1.14e-49

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 166.31  E-value: 1.14e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15917   9 AMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15917  89 GVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQ---YELMVYVTGVTFLLLplsAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYV-------LP 262
Cdd:cd15917 169 RVnsiYGLFVALLIVGFDLL---FIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthrfghhVP 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576871 263 SSLHStkqdnITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15917 246 PHVHI-----LLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
34-297 6.72e-48

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 161.69  E-value: 6.72e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15221  10 MYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSwIMASLTAVGHTVYTM-HFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15221  90 ILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAA-VARSFCIVFPFVFLLkRLPYCGHNVIPHTYCEHMGIARLACADI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYelMVYVTGVTFLLLPLSA--IVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYV-------LPS 263
Cdd:cd15221 169 TVN--IWYGLTVALLTVGLDVvlIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthrfgrhIPR 246
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576871 264 SLHStkqdnITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15221 247 HVHI-----LLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
33-297 7.12e-47

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 159.12  E-value: 7.12e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15950   9 SMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15950  89 GVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADP 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 ---SQYELMV--YVTGVTFLLlplsaIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATF-MYV------ 260
Cdd:cd15950 169 rpsSLYSITGstLVVGTDSAF-----IAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTqrfgqg 243
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576871 261 LPSSLHSTKQDnitsvFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15950 244 VPPHTQVLLAD-----LYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
33-297 2.91e-44

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 152.15  E-value: 2.91e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15952   9 AVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNY-MIFMSPTVCWfIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVD 191
Cdd:cd15952  89 AVLVAMAFDRYVAICNPLRYtTILTNKVISV-IALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACAS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 192 TsQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYV-------LPSS 264
Cdd:cd15952 168 I-RINIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthrfghnIPRY 246
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576871 265 LHStkqdnITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15952 247 IHI-----LLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
31-297 2.64e-43

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 149.72  E-value: 2.64e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  31 VTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSA 110
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 111 EDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCV 190
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 191 DTSQYelMVYVTGVTFLL--LPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYV-------L 261
Cdd:cd15953 167 DTTIN--RIYGLVVALLVvgLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthrfgqgI 244
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576871 262 PSSLHStkqdnITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15953 245 APHIHI-----ILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
33-297 1.54e-42

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 147.88  E-value: 1.54e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15951   9 IMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15951  89 GIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 ---SQYELMV--YVTGVTFLLlplsaIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHS 267
Cdd:cd15951 169 rvsRAYGLSVafLVGGLDVIF-----IAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHN 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 47576871 268 TKQDN--ITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15951 244 VPPHVhiLIANVYLLVPPMLNPIIYGVRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
33-305 1.94e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 134.55  E-value: 1.94e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871    33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:pfam13853   3 LMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMES 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871   113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:pfam13853  83 AVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871   193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQ-- 270
Cdd:pfam13853 163 KVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPll 242
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 47576871   271 DNITSVFYTIVTPALNPLIYSLRNKEVIGALRRVL 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
33-297 5.20e-37

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 133.39  E-value: 5.20e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15222   9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYM-IFMSPTVcwfivstswIMASLTAVGHTVYTM--------HFPFCMSQEIRHLLCEILP 183
Cdd:cd15222  89 SVLLAMAFDRFVAICNPLRYAsILTNSRI---------AKIGLAIVLRSVLLLlplpfllkRLPFCHSNVLSHSYCLHQD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 184 LLKLSCVDT---SQYELMV--YVTGVTFLLlplsaIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFY----GA 254
Cdd:cd15222 160 VMKLACSDTrvnSIYGLFVvlSTMGLDSLL-----ILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYvpmiGL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47576871 255 AT---FMYVLPSSLHStkqdnITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15222 235 SMvhrFGKHASPLVHV-----LMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
33-297 1.29e-36

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 132.34  E-value: 1.29e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15948  10 SAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMES 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDT 192
Cdd:cd15948  90 AVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 193 SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAAtfmyVLPSSLHSTKQDN 272
Cdd:cd15948 170 RFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPV----VLSSTMHRFARHV 245
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576871 273 ITSV------FYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15948 246 APHVhillanFYLLFPPMMNPIVYGVKTKQI 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
34-297 7.09e-36

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 130.37  E-value: 7.09e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15956  10 IYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVcwfiVSTSWIMASLTAVGHTVY----TMHFPFCMSQEIRHLLCEILPLLKLSC 189
Cdd:cd15956  90 VLVAMALDRFVAICNPLHYATILTLEV----VAKAGLLLALRGVAIVIPfpllVCRLSFCASHTIAHTYCEHMAVVKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 190 VDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTK 269
Cdd:cd15956 166 GATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVP 245
                       250       260       270
                ....*....|....*....|....*....|
gi 47576871 270 QDN--ITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15956 246 SAAhvLLSNLYLLLPPALNPIVYGIRTKQI 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
42-290 1.75e-34

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 126.26  E-value: 1.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871    42 NGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKEN-TISFGGCALQMALALMLGSAEDLLLAFMAY 120
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871   121 DRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHfpfCMSQEIRHLLCEILPLLKLSCvdtsqYELMVY 200
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSK-----PVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871   201 VTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEG-------KKKALVTCLSHLMVVGMFYGAATFMYVLPSSLHSTKQDNI 273
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRKSASKQKssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 47576871   274 TSVFYTI------VTPALNPLIY 290
Cdd:pfam00001 234 LDKALSVtlwlayVNSCLNPIIY 256
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
10-297 3.60e-32

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 121.04  E-value: 3.60e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  10 SGFILVGILNGSSSPELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKE 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  90 NTISFGGCALQMALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 170 MSQEIRHLLCEILPLLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVG 249
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47576871 250 MFYgaatfMYVLPSSLHSTKQDNIT-------SVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15949 242 AFY-----VPIAVSSLIHRFGQNVPppthillANFYLLIPPMLNPIVYGVRTKQI 291
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
33-297 3.43e-31

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 117.95  E-value: 3.43e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15955   9 IMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFES 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMAS-LTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVD 191
Cdd:cd15955  89 GILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVvLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAADD 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 192 TSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYV-------LPSS 264
Cdd:cd15955 169 VRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahrfghhVAPY 248
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576871 265 LHStkqdnITSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15955 249 VHI-----LLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
34-297 8.58e-30

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 114.15  E-value: 8.58e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15954  10 MYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLSCVDTS 193
Cdd:cd15954  90 VLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIR 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGMFYGAATFMYVLP--SSLHSTKQD 271
Cdd:cd15954 170 VDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHrfGGHHITPHI 249
                       250       260
                ....*....|....*....|....*..
gi 47576871 272 NI-TSVFYTIVTPALNPLIYSLRNKEV 297
Cdd:cd15954 250 HIiMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
29-294 4.80e-18

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 82.34  E-value: 4.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLG 108
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 109 SAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRhllceilpllkLS 188
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCC-----------LC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 189 CVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLH--------------MPSNEGKKKALVTClshLMVVGMF--- 251
Cdd:cd00637 152 WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTL---LIVVVVFllc 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47576871 252 ---YGAATFMYVLPSSLHSTKQD-NITSVFYTIVTPALNPLIYSLRN 294
Cdd:cd00637 229 wlpYFILLLLDVFGPDPSPLPRIlYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-296 4.09e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 67.97  E-value: 4.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAvghtvytmhFPFCMsqeIRHLLCEILPLL 185
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLIS---------LPPLV---GWRDETQPSVVD 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVYVTGVTFllLPLSAIVTSYTLILSTVLHmpsnegKKKALVTcLShlMVVGMFYGA-ATFMYVLPSS 264
Cdd:cd14967 149 CECEFTPNKIYVLVSSVISFF--IPLLIMIVLYARIFRVARR------ELKAAKT-LA--IIVGAFLLCwLPFFIIYLVS 217
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576871 265 LHSTKqDNITSVFYTIVT------PALNPLIYSLRNKE 296
Cdd:cd14967 218 AFCPP-DCVPPILYAVFFwlgylnSALNPIIYALFNRD 254
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
36-154 7.08e-10

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 58.72  E-value: 7.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  36 ILALTSNGPLLLVITVD--ARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMdfLLKENTISFGG--CALQMALALMLGSAE 111
Cdd:cd15055  10 ISLLTVLGNLLVIISIShfKQLHTPTNLLLLSLAVADFLVGLLVMPFSMI--RSIETCWYFGDtfCKLHSSLDYILTSAS 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47576871 112 DLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASL 154
Cdd:cd15055  88 IFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSAL 130
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
26-165 2.09e-09

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 57.25  E-value: 2.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNgplLLVITVDA---RLHVPMYFLLRQLSLIDLLFTSVVTPKAvMDFLLkENTISFGG--CALQ 100
Cdd:cd15314   2 LLYIFLGLISLVTVCGN---LLVIISIAhfkQLHTPTNYLILSLAVADLLVGGLVMPPS-MVRSV-ETCWYFGDlfCKIH 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47576871 101 MALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMH 165
Cdd:cd15314  77 SSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELN 141
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
25-296 3.17e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 56.83  E-value: 3.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  25 ELLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALA 104
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYmIFMSPTVCWFIVSTSWIMASLTAVghtvytmhFPFC----MSQEIRHLLCE 180
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWAL--------PPLFgwssYVPEGGGTSCS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 181 IlpllKLSCVDTSQYELMVYVTgVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKAL------------VTCLSHLMVV 248
Cdd:cd14969 152 V----DWYSKDPNSLSYIVSLF-VFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSaitkrtkkaekkVAKMVLVMIV 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47576871 249 GMF-----YGAATFMYVLpsslhsTKQDNITSVFYTIvtPAL--------NPLIYSLRNKE 296
Cdd:cd14969 227 AFLiawtpYAVVSLYVSF------GGESTIPPLLATI--PALfaksstiyNPIIYVFMNKQ 279
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
36-296 2.60e-08

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 54.18  E-value: 2.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  36 ILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKenTISFGGCALQMALALMLGSAEDLLL 115
Cdd:cd14968  12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGL--PTNFHGCLFMACLVLVLTQSSIFSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 116 AFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLtaVGHTvytmhfPFcMSQEIRHLLCEILPLLKLSCVDTS-- 193
Cdd:cd14968  90 LAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFL--VGLT------PM-FGWNNGAPLESGCGEGGIQCLFEEvi 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 194 QYELMVYVTGVTFLLLPLSAIVTSYTLILSTVlhmpSNEGKKKALVTCLSHL---------------MVVGMF------- 251
Cdd:cd14968 161 PMDYMVYFNFFACVLVPLLIMLVIYLRIFRVI----RKQLRQIESLLRSRRSrstlqkevkaakslaIILFLFalcwlpl 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47576871 252 YGAATFMYVLPsslhsTKQDNITSVFYTIV----TPALNPLIYSLRNKE 296
Cdd:cd14968 237 HIINCITLFCP-----ECKVPKILTYIAILlshaNSAVNPIVYAYRIRK 280
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
39-158 3.19e-08

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 53.90  E-value: 3.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  39 LTSNGPLLLVITVD--ARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLlkENTISFGG--CALQMALALMLGSAEDLL 114
Cdd:cd15312  13 LTVFGNLMVIISIShfKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSV--ESCWYFGDlfCKIHSSLDMMLSTTSIFH 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576871 115 LAFMAYDRYVAICHPLNYMIFMS-PTVCWFIVsTSWIMASLTAVG 158
Cdd:cd15312  91 LCFIAVDRYYAVCDPLHYRTKITtPVIKVFLV-ISWSVPCLFAFG 134
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
26-290 6.22e-08

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 53.11  E-value: 6.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15389   2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMifMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCeilpll 185
Cdd:cd15389  82 CSVYVSTLTLTAIALDRHRVILHPLKPR--ITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRC------ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 kLSCVDTSQYELMVYVTGVTFLL---LPLSAIVTSYTLI------------LSTVLHMPSNEGKKKAlvtcLSHLMVVGM 250
Cdd:cd15389 154 -LPSFPEPSDLFWKYLDLATFILqyvLPLLIIGVAYTRVakklwlrnaigdVTTEQYVAQRRKKKKT----IKMLMLVVL 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576871 251 FYGAATF---MYVLPSSLHSTKQDN----------ITSVFYtivtpalNPLIY 290
Cdd:cd15389 229 LFAICWLplnCYHVLLSSHPIRSNSalffafhwlaMSSTCY-------NPFIY 274
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
26-225 8.04e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 52.74  E-value: 8.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFL-LKENTISFGGCALQMALA 104
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAvghtvytMHFPFCMSQEIRHLLCEILPL 184
Cdd:cd14979  82 EACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA-------IPILFLMGIQYLNGPLPGPVP 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 47576871 185 LKLSC---VDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTV 225
Cdd:cd14979 155 DSAVCtlvVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKL 198
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
26-292 2.07e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 51.34  E-value: 2.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15054   2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHfpfCMSQEIRHLLCEILPLL 185
Cdd:cd15054  82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWH---ELGHERTLPNLTSGTVE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 186 KLSCVDTSQYELMVyVTGVTFlLLPLSAIVTSYTLILSTVlhmpsnegkKKALVTCLSHLMVVGMFYgaATFMYVLPSSL 265
Cdd:cd15054 159 GQCRLLVSLPYALV-ASCLTF-FLPSGAICFTYCRILLAA---------RKALKASLTLGILLGMFF--VTWLPFFVANV 225
                       250       260       270
                ....*....|....*....|....*....|...
gi 47576871 266 HSTKQDNITSVFYTIVT------PALNPLIYSL 292
Cdd:cd15054 226 VQAVCDCVSPGLFDVLTwlgycnSTMNPIIYPL 258
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
26-228 3.10e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 51.06  E-value: 3.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLH-VPMYFLLrQLSLIDLLFTSVVTPKAVMDFLLKENtisFGGCALQMALA 104
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRtVTNYFLV-NLAVADLLVSLFCMPLTLLENVYRPW---VFGEVLCKAVP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLG---SAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAvghtvytmhFPFCMSQEIRHL-LCE 180
Cdd:cd14993  78 YLQGvsvSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIM---------LPLLVVYELEEIiSSE 148
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576871 181 ILPLLKLSCVD--TSQYELMVYVTGVTFLL--LPLSAIVTSYTLILSTVLHM 228
Cdd:cd14993 149 PGTITIYICTEdwPSPELRKAYNVALFVVLyvLPLLIISVAYSLIGRRLWRR 200
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
29-225 6.44e-07

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 50.07  E-value: 6.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLlFTSVVTpkaVMDFLLKENTISFGG----CALQMALA 104
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADL-VVAFFT---VLTQIIWEATGEWVAgdvlCRIVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMifMSPTVCWFIVSTSWIMASLTA-----------VGHTVYTmhfpfCMSQE 173
Cdd:cd14986  81 VVGLFASTYILVSMSLDRYQAIVKPMSSL--KPRKRARLMIVVAWVLSFLFSipqlvifvereLGDGVHQ-----CWSSF 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576871 174 IrhllceilpllklscvdtSQYELMVYVTGVTFLLL--PLSAIVTSYTLILSTV 225
Cdd:cd14986 154 Y------------------TPWQRKVYITWLATYVFviPLIILSYCYGRILRTI 189
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
30-150 1.05e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 49.37  E-value: 1.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILaLTSNGPLLLVITVD--ARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLlkENTISFGG--CALQMALAL 105
Cdd:cd15317   5 IVLVLAML-ITVSGNLVVIISIShfKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTV--ETCWYFGDlfCKFHTGLDL 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWI 150
Cdd:cd15317  82 LLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
29-157 2.27e-06

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 48.00  E-value: 2.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSV-VTPKAVMDFllkenTISFGG----CAL--QM 101
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIWDI-----TYRFYGgdllCRLvkYL 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47576871 102 ALALMLGSAedLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVStSWIMASLTAV 157
Cdd:cd15196  80 QVVGMYASS--YVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAI-AWVLSLLLSI 132
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
32-296 4.84e-06

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 47.26  E-value: 4.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  32 TALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAE 111
Cdd:cd14982   8 SLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYGS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 112 DLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVghtvytmhfPFCMSQEIRHLLCEILPLLKLSCVD 191
Cdd:cd14982  88 ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASV---------PLLLLRSTIAKENNSTTCFEFLSEW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 192 TSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEG----KKKALVTCLSHLMV-VGMF--YGAATFMYVL--P 262
Cdd:cd14982 159 LASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVfLVCFlpYHVTRILYLLvrL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47576871 263 SSLHSTKQDNITSVFYTI------VTPALNPLIYSLRNKE 296
Cdd:cd14982 239 SFIADCSARNSLYKAYRItlclasLNSCLDPLIYYFLSKT 278
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
30-226 8.37e-06

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 46.66  E-value: 8.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILA----LTSNGPLLLVITVDARlHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMAL-- 103
Cdd:cd15372   2 LVPSLYTLVflvgLPANGLALWVLATQVK-RLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFfy 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 104 ALMLGSAedLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFcmsQEIRHLLC-EIL 182
Cdd:cd15372  81 GNMYCSV--LLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPL---ERLNITLChDVL 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 47576871 183 PLLKlscvDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVL 226
Cdd:cd15372 156 PLDE----QDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLL 195
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
33-157 8.82e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 46.51  E-value: 8.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  33 ALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd15330   9 TLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAV 157
Cdd:cd15330  89 LHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISI 133
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
32-301 1.03e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 46.13  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  32 TALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLL------------FTSVVTPKAVMDFLLKentisfggCAL 99
Cdd:cd14972   6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLagiafvftflsvLLVSLTPSPATWLLRK--------GSL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 100 QMALALMLGSaedllLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAvghtvytmhfpfcmsqeirhllc 179
Cdd:cd14972  78 VLSLLASAYS-----LLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLA----------------------- 129
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 180 eILPLLKLSCVDTSQ---------YELMVYVTGVTFLLLPLSAIVTSYTLILStVLHMPSNEGKKKALVTCLSHL----- 245
Cdd:cd14972 130 -LLPVLGWNCVLCDQescsplgpgLPKSYLVLILVFFFIALVIIVFLYVRIFW-CLWRHANAIAARQEAAVPAQPstsrk 207
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47576871 246 ------MVVGMF-YGAATFMYVLPSSLHSTKQDNITSVFYTIVTPAL-----NPLIYSLRNKEVIGAL 301
Cdd:cd14972 208 laktvvIVLGVFlVCWLPLLILLVLDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-162 1.08e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 46.35  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLlftsVVTPKAVMDFLLKENTISFGG----CALQMALA 104
Cdd:cd15387   5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADL----VVAVFQVLPQLIWDITFRFYGpdflCRLVKYLQ 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYM--------IFMSPTVCWFIVSTSWIMASLTAVGHTVY 162
Cdd:cd15387  81 VVGMFASTYMLLLMSIDRCLAICQPLRSLhrrsdrvyVLFSWLLSLVFSIPQVHIFSLREVGNGVY 146
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
30-292 1.09e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 46.13  E-value: 1.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALY----ILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVtPKAVMDFLLkeNTISFGG--CALQMAL 103
Cdd:cd14970   2 VIPAVYsvvcVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLL--GYWPFGEvmCKIVLSV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 104 ALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYtmhfpfcmSQEIRHLLCEILP 183
Cdd:cd14970  79 DAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIF--------ARTLQEEGGTISC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 184 LLKLSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLIL-----STVLHMPSNEGKKKAL--VTCLShLMVVGMFYGAAT 256
Cdd:cd14970 151 NLQWPDPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIrrlrsSRNLSTSGAREKRRARrkVTRLV-LVVVAVFVVCWL 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47576871 257 FMYVLPSSLHSTKQDNIT---SVFYTIVT-----PALNPLIYSL 292
Cdd:cd14970 230 PFHVFQIVRLLIDPPETLtvvGVFLFCIAlsyanSCLNPILYAF 273
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
30-154 2.02e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 45.42  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGS 109
Cdd:cd15065   5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCST 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576871 110 AEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASL 154
Cdd:cd15065  85 ASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
26-157 3.43e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 44.85  E-value: 3.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILaltsnGPLLLVITVD--ARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLlkENTISFGG--CALQM 101
Cdd:cd15318   5 LACAIGMLIIVL-----GNLFVVVTVShfKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSV--ESCWYFGDsfCRLHT 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576871 102 ALALMLGSAEDLLLAFMAYDRYVAICHPLNY-MIFMSPTVCWFIVSTSWIMASLTAV 157
Cdd:cd15318  78 CLDTLFCLTSIFHLCFISIDRHCAICDPLLYpSKFTIRVACIFIAAGWLVPTVYTSV 134
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-147 7.89e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 43.66  E-value: 7.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLlftsVVTPKAVMDFLLKENTISFGG----CALQMALA 104
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADL----VVAFFQVLPQLCWDITYRFYGpdflCRIVKHLQ 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPL---------NYMIFMSPTVCWFIVST 147
Cdd:cd15385  81 VLGMFASTYMLVMMTADRYIAICHPLktlqqptkrSYLMIGSAWALSFILST 132
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
26-181 8.70e-05

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 43.26  E-value: 8.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15202   2 LLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIfmSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEI 181
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLE 155
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-236 8.80e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 43.20  E-value: 8.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLtavghtvytMHFP-FCMSQEIRHLLCEILPL 184
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAV---------YNTPyFVFSQTVEILVTQDGQE 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576871 185 LKLSCVDTSQYELMVY--VTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKK 236
Cdd:cd15012 152 EEICVLDREMFNSKLYdtINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
36-156 9.04e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 43.59  E-value: 9.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  36 ILALTSNGPLLLVITVD--ARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15058  10 IILAIVVGNLLVIIAIArtSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIE 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTA 156
Cdd:cd15058  90 TLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVS 132
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
26-157 1.04e-04

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 43.09  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAV 157
Cdd:cd15064  82 TCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL 133
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
24-295 1.26e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 43.00  E-value: 1.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  24 PELLCAIVTALYILAltsNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLK-ENTISFGGCALQMA 102
Cdd:cd15304   3 PALLTVIVIILTIAG---NILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 103 LALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEil 182
Cdd:cd15304  80 LDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLAD-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 183 pllklscvdtsqyELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVVGM--FYGAATFMYV 260
Cdd:cd15304 158 -------------ENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMWcpFFITNVMAVI 224
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576871 261 LPSSLHSTKQDNITSVFYTI--VTPALNPLIYSLRNK 295
Cdd:cd15304 225 CKESCNEVVIGGLLNVFVWIgyLSSAVNPLVYTLFNK 261
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
61-154 1.61e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 42.68  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  61 FLLRQLSLIDLLFTSVVTP-KAVMDFllkENTISFGG-CALQMALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSP 138
Cdd:cd15320  39 FFVISLAVSDLLVAVLVMPwKAVAEI---AGFWPFGSfCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTP 115
                        90
                ....*....|....*.
gi 47576871 139 TVCWFIVSTSWIMASL 154
Cdd:cd15320 116 KVAFIMISVAWTLSVL 131
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
26-152 1.66e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.60  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15335   2 LIVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDM 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMA 152
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTIS 128
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
26-154 1.75e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 42.34  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMdFLLKENTISFGG--CALQMAL 103
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSIL-HEMTGGYWLFGRdwCDVWHSF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47576871 104 ALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASL 154
Cdd:cd15067  80 DVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSAL 130
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
26-150 2.11e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 42.32  E-value: 2.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLH-VPMYFLLrQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALA 104
Cdd:cd15051   2 VLGVVLAVIILLTVIGNVLVCLAVAVNRRLRnLTNYFIV-SLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWI 150
Cdd:cd15051  81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWV 126
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
34-238 2.19e-04

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 42.20  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARL-HVPMYFLLrQLSLIDLLFtsVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAED 112
Cdd:cd14984  10 VFLLGLVGNSLVLLVLLYYRKLrSMTDVYLL-NLALADLLF--VLTLPFWAVYAADGWVFGSFLCKLVSALYTINFYSGI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 113 LLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMhfpfcMSQEIRHLLCEIL--PLLKLSCV 190
Cdd:cd14984  87 LFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQ-----VSEENGSSICSYDypEDTATTWK 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 47576871 191 DTSQYELMVYvtgvtFLLLPLSAIVTSYTLILSTVLHMPsNEGKKKAL 238
Cdd:cd14984 162 TLLRLLQNIL-----GFLLPLLVMLFCYSRIIRTLLRAR-NHKKHRAL 203
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
24-309 2.22e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 42.20  E-value: 2.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  24 PELLCAIVTalyILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKEN-TISFGGCALQMA 102
Cdd:cd15305   3 PALLILIII---ILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWIS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 103 LALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWimasltavghtvyTMHFPFCMSQEIRHLLCEIL 182
Cdd:cd15305  80 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------------TISIGISMPIPVIGLQDDEK 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 183 PLLKLSCVDTSqyELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMPSNEGKKKA-----LVTCLSHLMVVGMFygAATF 257
Cdd:cd15305 147 VFVNGTCVLND--ENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRAskvlgIVFFLFLIMWCPFF--ITNI 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47576871 258 MYVL-PSSLHSTKQDNITSVFYTI--VTPALNPLIYSLRNKevigALRRVLGRYI 309
Cdd:cd15305 223 LSVLcKEACDQKLMEELLNVFVWVgyVSSGINPLVYTLFNK----TYRRAFSNYI 273
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
26-229 2.58e-04

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 42.14  E-value: 2.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDAR---LHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMA 102
Cdd:cd15355   2 LVTAIYLALFVVGTVGNSITLYTLARKKSlqhLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 103 LALMLGS--AEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVgHTVYTMHFPFCMSQEIRHLLCE 180
Cdd:cd15355  82 YFLRDACtyATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAI-PMLFTMGEQNRSGTHPGGLICT 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 47576871 181 ilpllklSCVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHMP 229
Cdd:cd15355 161 -------PIVDTSTLKVVIQVNAFLSFLFPMLVISVLNTLIANQLTVMV 202
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
39-163 2.95e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 41.77  E-value: 2.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  39 LTSNGPLLLVITVD--ARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLlkENTISFGG--CALQMALALMLGSAEDLL 114
Cdd:cd15316  13 LAVFGNLLVMISILhfKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSV--ESCWYFGEsfCTFHTCCDVSFCYASLFH 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47576871 115 LAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMaSLTAVGHTVYT 163
Cdd:cd15316  91 LCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIF-SLTYSFSVFYT 138
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
34-163 3.31e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 41.69  E-value: 3.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTsVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15094  10 ICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFL-IGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSF 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYT 163
Cdd:cd15094  89 TLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYA 138
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
30-295 4.47e-04

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 41.14  E-value: 4.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITVDARLH-VPMYFLLrQLSLIDLLFTSVVTPKAVM-DFLLKENTISFGGCALQMALALML 107
Cdd:cd15052   6 LLLLLVIATIGGNILVCLAISLEKRLQnVTNYFLM-SLAIADLLVGLLVMPLSILtELFGGVWPLPLVLCLLWVTLDVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 108 GSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIrhllceilpllkl 187
Cdd:cd15052  85 CTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNG------------- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 188 SCVDTSQYeLMVYVTGVTFlLLPLSAIVTSYTLilstVLHMPSNEGKKKALVTCLSHLMVV--GMFYgAATFMYVLPSSL 265
Cdd:cd15052 152 TCVLFNPN-FVIYGSIVAF-FIPLLIMVVTYAL----TIRLLSNEQKASKVLGIVFAVFVIcwCPFF-ITNILTGLCEEC 224
                       250       260       270
                ....*....|....*....|....*....|..
gi 47576871 266 HSTKQDNITSVFYTI--VTPALNPLIYSLRNK 295
Cdd:cd15052 225 NCRISPWLLSVFVWLgyVSSTINPIIYTIFNK 256
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
26-161 4.58e-04

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 41.09  E-value: 4.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVtPKAVMDFLLkeNTISFGGCALQMALAL 105
Cdd:cd15091   2 IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLM--NSWPFGDVLCKIVISI 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 ----MLGSAedLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTV 161
Cdd:cd15091  79 dyynMFTSI--FTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIV 136
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
26-157 6.51e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 40.70  E-value: 6.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMdFLLKENTISFGG-CALQMALA 104
Cdd:cd15334   2 LISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIM-YIVKETWIMGQVvCDIWLSVD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAV 157
Cdd:cd15334  81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISM 133
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
30-154 6.82e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 40.49  E-value: 6.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITV---DARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALM 106
Cdd:cd15050   3 LGIALSTISLITVILNLLVLYAvrtERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYV 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47576871 107 LGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASL 154
Cdd:cd15050  83 ASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFL 130
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
36-221 7.77e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 40.53  E-value: 7.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  36 ILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLlkENTISFGGCALQMALALMLGSAEDLLL 115
Cdd:cd15070  12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL--GVTIHFYSCLFMSCLLVVFTHASIMSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 116 AFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLCEILPLLKLscvdtsqy 195
Cdd:cd15070  90 LAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRM-------- 161
                       170       180
                ....*....|....*....|....*.
gi 47576871 196 ELMVYVTGVTFLLLPLSAIVTSYTLI 221
Cdd:cd15070 162 DYMVYFSFFTWILIPLVIMCALYVDI 187
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
36-156 7.80e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.52  E-value: 7.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  36 ILALTSNGPLLLVITV--DARLHVPMYFLLRQLSLIDLLFTSVVTPkAVMDFLLKENTISFG--GCALQMALALMLGSAE 111
Cdd:cd15005  10 ILCVSLAGNLLFSVLIvrDRSLHRAPYYFLLDLCLADGLRSLACFP-FVMASVRHGSGWIYGalSCKVIAFLAVLFCFHS 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576871 112 DLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTA 156
Cdd:cd15005  89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMA 133
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
54-157 1.02e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 40.35  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  54 RLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTIsFGG--CALQMALALMLGSAEDLLLAFMAYDRYVAICHPLN 131
Cdd:cd14997  30 DMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWL-LGEfmCKLVPFVELTVAHASVLTILAISFERYYAICHPLQ 108
                        90       100
                ....*....|....*....|....*.
gi 47576871 132 YMIFMSPTVCWFIVSTSWIMASLTAV 157
Cdd:cd14997 109 AKYVCTKRRALVIIALIWLLALLTSS 134
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
29-228 1.34e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 39.69  E-value: 1.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPkavMDFLLKENTISFGG---CALQMALAL 105
Cdd:cd15195   5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP---MDAVWNYTVEWLAGdlmCRVMMFLKQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNymIFMSPTVCWFIVSTSWIMASLTAVGhtvytmhfPFCMSQEIRHLlCEilPLL 185
Cdd:cd15195  82 FGMYLSSFMLVVIALDRVFAILSPLS--ANQARKRVKIMLTVAWVLSALCSIP--------QSFIFSVLRKM-PE--QPG 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 47576871 186 KLSCVDT------SQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHM 228
Cdd:cd15195 149 FHQCVDFgsaptkKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKM 197
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
26-156 1.37e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 39.82  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILAltSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVM-DFLLKENTISFGGCALQMALA 104
Cdd:cd15308   4 LVGGVLLILAIIA--GNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYsEFQGGVWTLSPVLCDALMTMD 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTA 156
Cdd:cd15308  82 VMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVA 133
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
30-154 1.57e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 39.72  E-value: 1.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITVDARLH--VPMYFLLrQLSLIDLLFTSVVTP-KAVMDFLlkeNTISFGG-CALQMALAL 105
Cdd:cd15057   6 ILYLLVLLTLLGNALVIAAVLRFRHLRskVTNYFIV-SLAVSDLLVAILVMPwAAVNEVA---GYWPFGSfCDVWVSFDI 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASL 154
Cdd:cd15057  82 MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSAL 130
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
46-248 1.66e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 39.29  E-value: 1.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  46 LLVITVDARLHVPMYFLlrQLSLIDLLFTSvvTPKAVMDFLLKENTISFGGCALQMALALMLGS--AEDLLLAFMAYDRY 123
Cdd:cd15160  24 VLYLQIKKENVLGVYLL--NLSLSDLLYIL--TLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNiyASIGFLCCIAVDRY 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 124 VAICHPLNYMIFMSPTVCWFIVSTSWImasLTAVGHTVYTMH-FPFCMSQEirHLLC-EILPLlklscvDTSQYELMVYV 201
Cdd:cd15160 100 LAVVHPLRFRGLRTRRFALKVSASIWV---LELGTHSVFLGHdELFRDEPN--HTLCyEKYPM------EGWQASYNYAR 168
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 47576871 202 TGVTFlLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLMVV 248
Cdd:cd15160 169 FLVGF-LIPLSLILFFYRRVLRAVRQSPSLEREEKRKIIGLLLSIVV 214
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
26-158 1.73e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15326   2 LLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVG 158
Cdd:cd15326  82 LCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIG 134
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-154 1.85e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 39.40  E-value: 1.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLlftsVVTPKAVMDFLLKENTISFGG----CALQMALA 104
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDL----VVALFQVLPQLIWEITYRFQGpdllCRAVKYLQ 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTsWIMASL 154
Cdd:cd15386  81 VLSMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGAT-WLLSCI 129
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
26-292 1.96e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 39.36  E-value: 1.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTsVVTPKAVMDFLLKENTIsFGG--CALQMAL 103
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFM-LGMPFLIHQFAIDGQWY-FGEvmCKIITAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 104 ALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIrhllCEI-L 182
Cdd:cd15088  80 DANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTF----CYVsL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 183 PllklscVDTSQYELMVYVTGVTFlLLPLSAIVTSYTLILSTVLHM--PSNEG--KKKALVTCLSHLMVVGMFYGAATFM 258
Cdd:cd15088 156 P------SPDDLYWFTIYHFILGF-AVPLVVITVCYILILHRLARGvaPGNQShgSSRTKRVTKMVILIVVVFIVCWLPF 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47576871 259 YVLPSSLHSTKQDNITSVF-YTI------VTPALNPLIYSL 292
Cdd:cd15088 229 HVVQLVNLAMNRPTLAFEVaYFLsiclgyANSCLNPFVYIL 269
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
29-167 1.98e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 39.15  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHV--PMYFLLRQLSLIDLLFTSVVTPKAVMDFLlkENTISFGGCALQMALALM 106
Cdd:cd14981   5 APPALMFVFGVLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVLAVYA--SNFEWDGGQPLCDYFGFM 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47576871 107 L---GSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWI----MASLTAVGHTVYTMHFP 167
Cdd:cd14981  83 MsffGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAfallIASLPLLGLGSYVLQYP 150
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
26-158 1.99e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 39.01  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15062   2 VVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVG 158
Cdd:cd15062  82 LCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIG 134
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
26-152 2.65e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 38.59  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLL--VITVDARLHVPMYFLLrQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMAL 103
Cdd:cd15219   1 LLAVLLVVVLVVSLLSNLLVLLcfLYSAELRKQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFL 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47576871 104 ALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMA 152
Cdd:cd15219  80 ETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHS 128
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-225 3.22e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 38.56  E-value: 3.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLlFTSVVTpkaVMDFLLKENTISF----GGCALQMALA 104
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADL-CVGLIN---VLTDIIWRITVEWragdFACKVIRYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMifMSPTVCWFIVSTSWIMASLTAVghtvyTMHFPFCMSQEIR-HLLCEILP 183
Cdd:cd15197  81 VVVTYASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSI-----PMLIIFEKTGLSNgEVQCWILW 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 47576871 184 llklscvdTSQYELMVYVTGVTFLL--LPLSAIVTSYTLILSTV 225
Cdd:cd15197 154 --------PEPWYWKVYMTIVAFLVffIPATIISICYIIIVRTI 189
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
26-155 3.64e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 38.50  E-value: 3.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLT 155
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLI 130
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
30-225 3.68e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 38.38  E-value: 3.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITVDaRLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLK-----ENTISFGGCALQMALA 104
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRK-SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADysssfLSYFYAYFLPYIYPLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGH--TVYTMHFPFCMSQEIRHLLCEIL 182
Cdd:cd14978  85 NTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRffEYEVVECENCNNNSYYYVIPTLL 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 47576871 183 PLlklscVDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTV 225
Cdd:cd14978 165 RQ-----NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRAL 202
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
27-221 3.78e-03

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 38.28  E-value: 3.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  27 LCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMD------FLLKEntisfGGCALQ 100
Cdd:cd15133   3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYElwqnypFLLGS-----GGCYFK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 101 MALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTvyTMHFPFCMSQEI-RHLLC 179
Cdd:cd15133  78 TFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNT--SLHGIKFLGSGVpASAQC 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47576871 180 EILPLLKLscvdtsqYELMVYVTGVTFLLLPLSAIVTSYTLI 221
Cdd:cd15133 156 TVRKPQAI-------YNMIPQHTGHLFFVLPMAVISVLYLLM 190
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
29-221 3.87e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 38.43  E-value: 3.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLH-VPMYFLLrQLSLIDLLFTSVVTPkAVMDFLLKENTIsFG--GCALQMALAL 105
Cdd:cd15390   5 IVFVVMVLVAIGGNLIVIWIVLAHKRMRtVTNYFLV-NLAVADLLISAFNTV-FNFTYLLYNDWP-FGlfYCKFSNFVAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMifMSPTVCWFIVSTSWIMASLTAVGHTVY--TMHFPFCMSQEIRHLLCEiLP 183
Cdd:cd15390  82 TTVAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQLLYstTETYYYYTGSERTVCFIA-WP 158
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 47576871 184 LLKLSCVDTSqYELMVYVtgVTFlLLPLSAIVTSYTLI 221
Cdd:cd15390 159 DGPNSLQDFV-YNIVLFV--VTY-FLPLIIMAVAYTRV 192
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
26-157 5.32e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 37.81  E-value: 5.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKavMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFK--IAYHIHGNNWIFGEALCRLVTVA 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576871 106 MLGS--AEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAV 157
Cdd:cd15162  80 FYGNmyCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTL 133
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-167 5.38e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 37.85  E-value: 5.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQ--------MALAL 105
Cdd:cd15103  10 LGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsMICSS 89
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47576871 106 MLGSAEDLLLafMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFP 167
Cdd:cd15103  90 LLASICSLLA--IAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYSDSVP 149
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-292 5.39e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 38.00  E-value: 5.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVP---MYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFG--GCALQ 100
Cdd:cd15130   2 LVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLqstVRYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGdaGCRGY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 101 MALALMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVghtvytmhfPFCMSQEIRHLLCE 180
Cdd:cd15130  82 YFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAI---------PMLFTMGLQNESDD 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 181 ILPLLKLSC---VDTSQYELMVYVTGVTFLLLPLSAIVTSYTLILSTVLHmpSNEGKKKALVTCLSHLMVVGMFYGAATF 257
Cdd:cd15130 153 GTHPGGLVCtpiVDTATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQ--ALRRGVLVLRAVVIAFVVCWLPYHVRRL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47576871 258 MYV-LPSSLHSTKQDNITSVFYTI------VTPALNPLIYSL 292
Cdd:cd15130 231 MFCyISDEQWTTFLFDFYHYFYMLtnalfyVSSAINPILYNL 272
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
34-179 6.24e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 37.87  E-value: 6.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  34 LYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGSAEDL 113
Cdd:cd15979  10 IFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTF 89
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47576871 114 LLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFCMSQEIRHLLC 179
Cdd:cd15979  90 SLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQC 155
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
29-152 6.57e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 37.48  E-value: 6.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLG 108
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMC 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47576871 109 SAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMA 152
Cdd:cd15063  85 TASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLS 128
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
26-158 6.58e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 37.56  E-value: 6.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15325   2 VLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVG 158
Cdd:cd15325  82 LCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIG 134
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
26-158 6.90e-03

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 37.70  E-value: 6.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALAL 105
Cdd:cd15083   2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGG 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576871 106 MLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVG 158
Cdd:cd15083  82 LFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP 134
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
30-296 7.18e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 37.58  E-value: 7.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYIL-ALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLG 108
Cdd:cd15327   5 VFLAIFILmAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 109 SAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPfcmsqeirhllceilPLLKLS 188
Cdd:cd15327  85 TASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPP---------------PPDESI 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 189 CVDTSQYELMVYVTGVTFlLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVtclshlMVVGMFYGA-ATFMYVLPSSLHS 267
Cdd:cd15327 150 CSITEEPGYALFSSLFSF-YLPLMVILVMYFRVYVVALKFSREKKAAKTLA------IVVGVFILCwFPFFFVLPLGSFF 222
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576871 268 TKQDNITSVFYTI-----VTPALNPLIYSLRNKE 296
Cdd:cd15327 223 PALKPSEMVFKVIfwlgyFNSCVNPIIYPCSSKE 256
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
30-156 7.78e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 37.54  E-value: 7.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGplLLVITVDA---RLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALM 106
Cdd:cd15957   5 IVMSLIVLAIVFGN--VLVITAIAkfeRLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47576871 107 LGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTA 156
Cdd:cd15957  83 CVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS 132
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
31-154 7.98e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 37.58  E-value: 7.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  31 VTALYILALTSNGPLLLV-ITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLGS 109
Cdd:cd15959   6 LLSLAILVIVGGNLLVIVaIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVT 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576871 110 AEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASL 154
Cdd:cd15959  86 ASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAA 130
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
26-221 8.25e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 37.41  E-value: 8.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMdFLLKENTISFGG--CALQMAL 103
Cdd:cd15394   2 LIIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLA-YAFEPRGWVFGRfmCYFVFLM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 104 ALMLGSAEDLLLAFMAYDRYVAICHPLNYMifMSPTVCWFIVSTSWIMASLTAVGHTVYTMHFPFcmsQEIRHLLCEilp 183
Cdd:cd15394  81 QPVTVYVSVFTLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEF---KGLDFSICE--- 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 47576871 184 llklSCVDTSQYELMVYVTGVTFL--LLPLSAIVTSYTLI 221
Cdd:cd15394 153 ----EFWFGQEKQRLAYACSTLLItyVLPLLAISLSYLRI 188
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
29-152 8.40e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 37.08  E-value: 8.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALT-SNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALML 107
Cdd:cd15333   8 AVLLALITLATTlSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITC 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576871 108 GSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMA 152
Cdd:cd15333  88 CTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVIS 132
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
30-154 8.76e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 37.13  E-value: 8.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  30 IVTALYILALTSNGPLLLVITVDARL-HVPMYFLLrQLSLIDLLFTSVVTPKAVMDFLLKENTISFGGCALQMALALMLG 108
Cdd:cd15215   5 LIVIFLCASLFGNIVLLLVFQRKPQLlQVANRFIF-NLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47576871 109 SAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASL 154
Cdd:cd15215  84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVL 129
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
26-292 8.80e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 37.31  E-value: 8.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  26 LLCAIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLLFTSVVTPKAVMDFLLKEN-TISFGGCALQMALA 104
Cdd:cd15134   2 PITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPwVFGEVFCKLRAFLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLNYMIFMSPTVCWFIVSTSWIMASLTAVghtvytmhfPFCMSQEIRHLLCEILPL 184
Cdd:cd15134  82 EMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAL---------PFAIQTRIVYLEYPPTSG 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871 185 LKLS----CVDTSQYELMVYVTGVT---FLLLPLSAIVTSYTLILSTVLHMPSNEGKKKALVTCLSHLM----------- 246
Cdd:cd15134 153 EALEesafCAMLNEIPPITPVFQLStflFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSQsrrtvlrmlva 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576871 247 -VVGMFYGAATF-----MYVLPSSLHSTKQDNITSVFYT-----IVTPALNPLIYSL 292
Cdd:cd15134 233 vVVAFFICWAPFhaqrlLTVYAKNMTPPYLFINRILFYIsgvlyYVSSTVNPILYNV 289
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
29-149 8.93e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 37.45  E-value: 8.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576871  29 AIVTALYILALTSNGPLLLVITVDARLHVPMYFLLRQLSLIDLlftsVVTPKAVMDFLLKENTISFGG----CALQMALA 104
Cdd:cd15388   5 AVLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADL----VVAFFQVLPQLVWDITDRFRGpdvlCRLVKYLQ 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47576871 105 LMLGSAEDLLLAFMAYDRYVAICHPLnyMIFMSPTVCWFI-VSTSW 149
Cdd:cd15388  81 VVGMFASSYMIVAMTFDRHQAICRPM--VTFQKGRARWNGpVCVAW 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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