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Conserved domains on  [gi|261245035|ref|NP_001001187|]
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zinc finger protein 738 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
15-73 1.10e-28

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.83  E-value: 1.10e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 261245035    15 LSFRDVAIDFSAEEWECLEPAQLDLYRDVMLENYSNLVFLGLASSKPYLVTCLEQIQEP 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-642 1.17e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 257 KPYKCEECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHY----------------PSRLSNHKKIHSGEKPFKCEV- 319
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelsrhlrthhnnPSDLNSKSLPLSNSKASSSSLs 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 320 -CGKAFRILSLLSKHKIIHTE-----ENPYKCEVCGKAFDYPSRLSNHAEMHTREKPYKCEV---CQKAFRSLSSFSKHK 390
Cdd:COG5048  112 sSSSNSNDNNLLSSHSLPPSSrdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAnslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 391 RIHTKDNYYNSELCGKAFIYPSRLSKHKKiCAGEKPYKCEVCGKAFHVASLLSKHRTIHTGEKLYKCEVCGKAFYYPSRL 470
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 471 SNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKRIHTGEK 537
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 538 PYKCEEC-------GKAFHYPSLLSKHKIIHTGEKPYKCD--ICDQAFHVPSKLSHHKIIHRGEKPH--KCEVCGKAFHY 606
Cdd:COG5048  351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 261245035 607 PSRLSNHKKIHSEEKPYKCEVCGKAFRILSLLSKHK 642
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 661-744 7.28e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 661 DYPSRlsthaKMHTR-EKPYKCEV--CQNAFRSLSSLSKHKiihkeekpyKSDICGQAFHVPSKLSHHKIIQTGEKPYKC 737
Cdd:COG5189  336 DTPSR-----MLKVKdGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRC 401


                 ....*..
gi 261245035 738 EVCGKAF 744
Cdd:COG5189  402 EVCDKRY 408
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 143-212 2.51e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245035 143 GEKPYKCEV--CGKAFCIPLLLSKHKIiHKGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 212
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-240 8.66e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.66e-03
                          10        20
                  ....*....|....*....|...
gi 261245035  218 LLVHKRVHTGEKPYKCTVCGKAF 240
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
15-73 1.10e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.83  E-value: 1.10e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 261245035    15 LSFRDVAIDFSAEEWECLEPAQLDLYRDVMLENYSNLVFLGLASSKPYLVTCLEQIQEP 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-55 6.31e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 6.31e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 261245035   14 MLSFRDVAIDFSAEEWECLEPAQLDLYRDVMLENYSNLVFLG 55
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 15-54 1.61e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.61e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 261245035  15 LSFRDVAIDFSAEEWECLEPAQLDLYRDVMLENYSNLVFL 54
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-642 1.17e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 257 KPYKCEECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHY----------------PSRLSNHKKIHSGEKPFKCEV- 319
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelsrhlrthhnnPSDLNSKSLPLSNSKASSSSLs 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 320 -CGKAFRILSLLSKHKIIHTE-----ENPYKCEVCGKAFDYPSRLSNHAEMHTREKPYKCEV---CQKAFRSLSSFSKHK 390
Cdd:COG5048  112 sSSSNSNDNNLLSSHSLPPSSrdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAnslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 391 RIHTKDNYYNSELCGKAFIYPSRLSKHKKiCAGEKPYKCEVCGKAFHVASLLSKHRTIHTGEKLYKCEVCGKAFYYPSRL 470
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 471 SNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKRIHTGEK 537
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 538 PYKCEEC-------GKAFHYPSLLSKHKIIHTGEKPYKCD--ICDQAFHVPSKLSHHKIIHRGEKPH--KCEVCGKAFHY 606
Cdd:COG5048  351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 261245035 607 PSRLSNHKKIHSEEKPYKCEVCGKAFRILSLLSKHK 642
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 661-744 7.28e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 661 DYPSRlsthaKMHTR-EKPYKCEV--CQNAFRSLSSLSKHKiihkeekpyKSDICGQAFHVPSKLSHHKIIQTGEKPYKC 737
Cdd:COG5189  336 DTPSR-----MLKVKdGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRC 401


                 ....*..
gi 261245035 738 EVCGKAF 744
Cdd:COG5189  402 EVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 606-698 2.29e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 606 YPSRLSNHKkihsEEKPYKCEV--CGKAFRILSLLSKHKIiHTEENPykcevcgKAFDYPSRLSTHAkMHTREKPYKCEV 683
Cdd:COG5189  337 TPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSPEKMNI-FSAKDKPYRCEV 403

                         90
                 ....*....|....*
gi 261245035 684 CQNAFRSLSSLSKHK 698
Cdd:COG5189  404 CDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
497-522 5.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 261245035  497 SLSKHKRIHTGEKPYKCKECGKAFRS 522
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 143-212 2.51e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245035 143 GEKPYKCEV--CGKAFCIPLLLSKHKIiHKGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 212
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-212 7.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.85e-03
                          10        20
                  ....*....|....*....|....
gi 261245035  189 RLSRHKKIHSEEKPYKCEVCGKAF 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-240 8.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.66e-03
                          10        20
                  ....*....|....*....|...
gi 261245035  218 LLVHKRVHTGEKPYKCTVCGKAF 240
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
15-73 1.10e-28

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 108.83  E-value: 1.10e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 261245035    15 LSFRDVAIDFSAEEWECLEPAQLDLYRDVMLENYSNLVFLGLASSKPYLVTCLEQIQEP 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-55 6.31e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 6.31e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 261245035   14 MLSFRDVAIDFSAEEWECLEPAQLDLYRDVMLENYSNLVFLG 55
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 15-54 1.61e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.61e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 261245035  15 LSFRDVAIDFSAEEWECLEPAQLDLYRDVMLENYSNLVFL 54
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-642 1.17e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 257 KPYKCEECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHY----------------PSRLSNHKKIHSGEKPFKCEV- 319
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelsrhlrthhnnPSDLNSKSLPLSNSKASSSSLs 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 320 -CGKAFRILSLLSKHKIIHTE-----ENPYKCEVCGKAFDYPSRLSNHAEMHTREKPYKCEV---CQKAFRSLSSFSKHK 390
Cdd:COG5048  112 sSSSNSNDNNLLSSHSLPPSSrdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAnslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 391 RIHTKDNYYNSELCGKAFIYPSRLSKHKKiCAGEKPYKCEVCGKAFHVASLLSKHRTIHTGEKLYKCEVCGKAFYYPSRL 470
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 471 SNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKRIHTGEK 537
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 538 PYKCEEC-------GKAFHYPSLLSKHKIIHTGEKPYKCD--ICDQAFHVPSKLSHHKIIHRGEKPH--KCEVCGKAFHY 606
Cdd:COG5048  351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNR 430

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 261245035 607 PSRLSNHKKIHSEEKPYKCEVCGKAFRILSLLSKHK 642
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-546 1.51e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 116 MNYYKCEECAKSFHSPSLSSEENRIHAGEKPYKCEV--CGKAFCIPLLLSKHKIIHKgenlykcevcgkafQHPSRLSRH 193
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH--------------NNPSDLNSK 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 194 KKIHSEEKPYKCEVCGKAFHFPSLLLVHKRVHTGEKPYK-------CTVCGKAFHYPSIFSKHKRIHTGEKPYKCE---E 263
Cdd:COG5048   97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPansL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 264 CGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSNHKKIHSgEKPFKCEVCGKAFRILSLLSKH-KIIHTEENP 342
Cdd:COG5048  177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 343 YKCEVCGKAFDYPSR-LSNHAEMHTRE-----KPYKCEVCQKAFRSLSSFSKHKR--IHTKDNYY----NSELCGKAFIY 410
Cdd:COG5048  256 SASESPRSSLPTASSqSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKpfscPYSLCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 411 PSRLSKHKKICAGEKPYKC--EVCGKAFHVASLLSKHRTIHtgeklykcevcgkafyyPSRLSNHKKIHTGEKPFQCEVC 488
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNF 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 261245035 489 GKAFCFPSSLSKHKRihTGEKPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKCEECGK 546
Cdd:COG5048  399 KRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
481-793 2.16e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 481 KPFQCEVCGKAFCFPSSLSKHKRIHTGEKPYKC--KECGKAFRSLSSLSKHKRIHTGEKPYkcEECGKAFHYPSLLSKHK 558
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 559 IIHTGEKPYKCDICDQ-----AFHVPSKLSHHKIIHRGEKPHKcEVCGKAFHYPSRLSNHKKIHSEEKpykcevCGKAFR 633
Cdd:COG5048  110 LSSSSSNSNDNNLLSShslppSSRDPQLPDLLSISNLRNNPLP-GNNSSSVNTPQSNSLHPPLPANSL------SKDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 634 ILSLLSKHKIIHTEENPYKCEvCGKAFDYPSRLSTHAKMHTREKPYKCEVCQNAF-------RSLSSLSKHKIIHKEEKP 706
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 707 YKSDI---CGQAFHVPSKLSHHKIIQTgekPYKCEVCGKAFCIPLLVSKHKR--VHTGENPY----NSQVYNKAFIYPLR 777
Cdd:COG5048  262 RSSLPtasSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGESLKpfscPYSLCGKLFSRNDA 338

                        330
                 ....*....|....*.
gi 261245035 778 LSKHKKICTKEKPYKC 793
Cdd:COG5048  339 LKRHILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 563-642 2.71e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 563 GEKPYKCDI--CDQAFHVPSKLSHHKII-HRGEKPHKCevcgkafhyPSRLSnHKKIHSEEKPYKCEVCGKAFRILSLLS 639
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHEN---------PSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ...
gi 261245035 640 KHK 642
Cdd:COG5189  416 YHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 353-447 2.83e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 353 DYPSRLSNHAEmhtrEKPYKCEV--CQKAFRSLSSFsKHKRIHTKDNYYNSElcgkafiYPSRlSKHKKICAGEKPYKCE 430
Cdd:COG5189  336 DTPSRMLKVKD----GKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHE-------NPSP-EKMNIFSAKDKPYRCE 402

                         90
                 ....*....|....*..
gi 261245035 431 VCGKAFHVASLLSKHRT 447
Cdd:COG5189  403 VCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 661-744 7.28e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 7.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 661 DYPSRlsthaKMHTR-EKPYKCEV--CQNAFRSLSSLSKHKiihkeekpyKSDICGQAFHVPSKLSHHKIIQTGEKPYKC 737
Cdd:COG5189  336 DTPSR-----MLKVKdGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRC 401


                 ....*..
gi 261245035 738 EVCGKAF 744
Cdd:COG5189  402 EVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 606-698 2.29e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 606 YPSRLSNHKkihsEEKPYKCEV--CGKAFRILSLLSKHKIiHTEENPykcevcgKAFDYPSRLSTHAkMHTREKPYKCEV 683
Cdd:COG5189  337 TPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSPEKMNI-FSAKDKPYRCEV 403

                         90
                 ....*....|....*
gi 261245035 684 CQNAFRSLSSLSKHK 698
Cdd:COG5189  404 CDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 227-310 3.46e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 227 GEKPYKCTV--CGKAfhYPSIFS-KHKRIHTgekpykceECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLS 303
Cdd:COG5189  346 DGKPYKCPVegCNKK--YKNQNGlKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 261245035 304 NHKKiHS 310
Cdd:COG5189  416 YHRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 283-361 3.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 283 GEKPYKCEV--CGKAFHYPSRLSNHKKiHSGEKPFKCEVCGKafrilsllSKHKIIHTEENPYKCEVCGKAFDYPSRLSN 360
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 261245035 361 H 361
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
497-522 5.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 261245035  497 SLSKHKRIHTGEKPYKCKECGKAFRS 522
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 591-674 7.74e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 591 GEKPHKCEV--CGKAFHYPSRLSNHKKiHSEEKPYKCEVCGKafrilsllSKHKIIHTEENPYKCEVCGKAFDYPSRLST 668
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 261245035 669 HAKMHT 674
Cdd:COG5189  417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-548 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....
gi 261245035  525 SLSKHKRIHTGEKPYKCEECGKAF 548
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 143-212 2.51e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 261245035 143 GEKPYKCEV--CGKAFCIPLLLSKHKIiHKGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 212
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 451-530 4.00e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261245035 451 GEKLYKCEV--CGKAFYYPSRLSNHKKiHTGEKPFQCEvcgkafcfPSSLSKHKRIHTGEKPYKCKECGKAFRSLSSLSK 528
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 261245035 529 HK 530
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-268 4.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|.
gi 261245035  248 KHKRIHTGEKPYKCEECGKAF 268
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-492 6.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.71e-03
                          10        20
                  ....*....|....*....|....
gi 261245035  469 RLSNHKKIHTGEKPFQCEVCGKAF 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-212 7.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.85e-03
                          10        20
                  ....*....|....*....|....
gi 261245035  189 RLSRHKKIHSEEKPYKCEVCGKAF 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-240 8.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.66e-03
                          10        20
                  ....*....|....*....|...
gi 261245035  218 LLVHKRVHTGEKPYKCTVCGKAF 240
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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