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Conserved domains on  [gi|49258204|ref|NP_001001854|]
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claudin-1 [Bos taurus]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10467089)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-173 2.64e-47

PMP-22/EMP/MP20/Claudin family;


:

Pssm-ID: 395662  Cd Length: 162  Bit Score: 152.91  E-value: 2.64e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204     5 GLQLLGFILAFLGWIGSIVSTALP-QWKVYSYASdnivtaQAIYEGLWMSCVSQS-TGQIQCKVfdslLNLNSTLQATRA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKV----LELNDALQAVQA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204    83 LMVIGILLGLIAIFVATVGMKCMKCMEDDEAqkmrmavfGGVIFLISGLAILVATAWYGNRIVQEFYDPMTPvNARYEFG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGRFKL--------AGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP-NRKYSFG 142

                         170
                  ....*....|.
gi 49258204   163 QALFIGWAAAS 173
Cdd:pfam00822 143 YSFILGWVAFA 153
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-173 2.64e-47

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 152.91  E-value: 2.64e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204     5 GLQLLGFILAFLGWIGSIVSTALP-QWKVYSYASdnivtaQAIYEGLWMSCVSQS-TGQIQCKVfdslLNLNSTLQATRA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKV----LELNDALQAVQA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204    83 LMVIGILLGLIAIFVATVGMKCMKCMEDDEAqkmrmavfGGVIFLISGLAILVATAWYGNRIVQEFYDPMTPvNARYEFG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGRFKL--------AGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP-NRKYSFG 142

                         170
                  ....*....|.
gi 49258204   163 QALFIGWAAAS 173
Cdd:pfam00822 143 YSFILGWVAFA 153
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
5-173 2.64e-47

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 152.91  E-value: 2.64e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204     5 GLQLLGFILAFLGWIGSIVSTALP-QWKVYSYASdnivtaQAIYEGLWMSCVSQS-TGQIQCKVfdslLNLNSTLQATRA 82
Cdd:pfam00822   2 LVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKV----LELNDALQAVQA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204    83 LMVIGILLGLIAIFVATVGMKCMKCMEDDEAqkmrmavfGGVIFLISGLAILVATAWYGNRIVQEFYDPMTPvNARYEFG 162
Cdd:pfam00822  72 LMILSIILGIISLIVFFFQLFTMRKGGRFKL--------AGIIFLVSGLCVLVGASIYTSRIATDFGNPFTP-NRKYSFG 142

                         170
                  ....*....|.
gi 49258204   163 QALFIGWAAAS 173
Cdd:pfam00822 143 YSFILGWVAFA 153
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 16-174 1.33e-03

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 38.17  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204    16 LGWIGSIVSTALPQWKVYSYASDNIVTAQAI--YEGLWMSC--------------VSQSTGQIQCKVFDSLLNLNSTL-- 77
Cdd:pfam13903   2 LAFALLLIAFATDYWLVLDVALTGINNYTCLfaHLGLWRHCfksevdvdsdnqtrFFGCLNQVPNPFPTFEEEIVSFSvt 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49258204    78 ------QATRALMVIGILLGLIAIFVATVGMKCmkcmeddeaQKMRMAVFGGVIFLISGLAILVATAWYGN---RIVQEF 148
Cdd:pfam13903  82 slpgltRFVQAFAILSLVLIVCGVVCGLLALPK---------QSVFLLLAAGILFLLSGVLGLLGVIVFGQsvkLVFEEY 152

                         170       180
                  ....*....|....*....|....*....
gi 49258204   149 YDPMTPV---NARYEFGQALFIGWAAASL 174
Cdd:pfam13903 153 FRQWMPEhqnNVRISFGWSFALAWAGVVL 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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