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Conserved domains on  [gi|163838635|ref|NP_001002005|]
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pannexin-2 [Mus musculus]

Protein Classification

innexin/pannexin family protein( domain architecture ID 2274)

innexin/pannexin family protein similar to mammalian pannexins and invertebrate innexins

Gene Ontology:  GO:0005243
PubMed:  28559187|15921654

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Innexin super family cl03000
Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans ...
 58-150 1.97e-08

Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.


The actual alignment was detected with superfamily member pfam00876:

Pssm-ID: 470716  Cd Length: 330  Bit Score: 56.43  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163838635   58 TVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE------LRDALPGVDASLWPSLFEHKF---LPYaL 128
Cdd:pfam00876  11 TVVILLFFALLVTAKQYVGDPIDCWVPAEFTGSWEEYINTYCWIEntytvpFEEDIPDEALNGERERKYISYyqwVPF-I 89

                          90       100
                  ....*....|....*....|...
gi 163838635  129 LAFAAIM-YVPALGWEFLASTRL 150
Cdd:pfam00876  90 LFFQAILfYLPRLLWKFLEGGRI 112
 
Name Accession Description Interval E-value
Innexin pfam00876
Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans ...
 58-150 1.97e-08

Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.


Pssm-ID: 459975  Cd Length: 330  Bit Score: 56.43  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163838635   58 TVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE------LRDALPGVDASLWPSLFEHKF---LPYaL 128
Cdd:pfam00876  11 TVVILLFFALLVTAKQYVGDPIDCWVPAEFTGSWEEYINTYCWIEntytvpFEEDIPDEALNGERERKYISYyqwVPF-I 89

                          90       100
                  ....*....|....*....|...
gi 163838635  129 LAFAAIM-YVPALGWEFLASTRL 150
Cdd:pfam00876  90 LFFQAILfYLPRLLWKFLEGGRI 112
 
Name Accession Description Interval E-value
Innexin pfam00876
Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans ...
 58-150 1.97e-08

Innexin; This family includes the Drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions. This family has been named the Innexins.


Pssm-ID: 459975  Cd Length: 330  Bit Score: 56.43  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163838635   58 TVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE------LRDALPGVDASLWPSLFEHKF---LPYaL 128
Cdd:pfam00876  11 TVVILLFFALLVTAKQYVGDPIDCWVPAEFTGSWEEYINTYCWIEntytvpFEEDIPDEALNGERERKYISYyqwVPF-I 89

                          90       100
                  ....*....|....*....|...
gi 163838635  129 LAFAAIM-YVPALGWEFLASTRL 150
Cdd:pfam00876  90 LFFQAILfYLPRLLWKFLEGGRI 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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