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Conserved domains on  [gi|50344994|ref|NP_001002169|]
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diamine acetyltransferase 1a.2 [Danio rerio]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
4-153 2.75e-17

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 74.26  E-value: 2.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994   4 FILRKAEPKDVSDILRLIKE-----LAKFEEMEEQVvltekELLEDGFGDH--PFYHCVVAEVpkDNQsiegytVVGFAm 76
Cdd:COG1247   2 MTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSE-----EEREAWFAAIlaPGRPVLVAEE--DGE------VVGFA- 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50344994  77 YYFTYDPWIG-KLLYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRGASDLSHEEG 153
Cdd:COG1247  68 SLGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPE 145
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
4-153 2.75e-17

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 74.26  E-value: 2.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994   4 FILRKAEPKDVSDILRLIKE-----LAKFEEMEEQVvltekELLEDGFGDH--PFYHCVVAEVpkDNQsiegytVVGFAm 76
Cdd:COG1247   2 MTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSE-----EEREAWFAAIlaPGRPVLVAEE--DGE------VVGFA- 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50344994  77 YYFTYDPWIG-KLLYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRGASDLSHEEG 153
Cdd:COG1247  68 SLGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPE 145
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-144 3.59e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 3.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994    27 FEEMEEQVVLTEKELLEDGFGDHPFYHCVVAEvpkdnqsiEGYTVVGFAMYYFTYDPWigKLLYLEDFYVMKEFRGYGMG 106
Cdd:pfam00583   8 LSEEFPEPWPDEPLDLLEDWDEDASEGFFVAE--------EDGELVGFASLSIIDDEP--PVGEIEGLAVAPEYRGKGIG 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 50344994   107 SEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRG 144
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIALYEKLG 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 70-126 3.58e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 3.58e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 50344994  70 TVVGFAMYYFtyDPWIGKLLYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMH 126
Cdd:cd04301   9 EIVGFASLSP--DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
4-153 2.75e-17

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 74.26  E-value: 2.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994   4 FILRKAEPKDVSDILRLIKE-----LAKFEEMEEQVvltekELLEDGFGDH--PFYHCVVAEVpkDNQsiegytVVGFAm 76
Cdd:COG1247   2 MTIRPATPEDAPAIAAIYNEaiaegTATFETEPPSE-----EEREAWFAAIlaPGRPVLVAEE--DGE------VVGFA- 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50344994  77 YYFTYDPWIG-KLLYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRGASDLSHEEG 153
Cdd:COG1247  68 SLGPFRPRPAyRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPE 145
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-144 3.59e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 59.84  E-value: 3.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994    27 FEEMEEQVVLTEKELLEDGFGDHPFYHCVVAEvpkdnqsiEGYTVVGFAMYYFTYDPWigKLLYLEDFYVMKEFRGYGMG 106
Cdd:pfam00583   8 LSEEFPEPWPDEPLDLLEDWDEDASEGFFVAE--------EDGELVGFASLSIIDDEP--PVGEIEGLAVAPEYRGKGIG 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 50344994   107 SEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRG 144
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIALYEKLG 115
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
6-144 4.45e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 60.10  E-value: 4.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994   6 LRKAEPKDVSDILRLIKELakFEEMEEQvvltekELLEDGFGDHPFYHCVVAEvpkdnqsiEGYTVVGFAMYYFTYDPWI 85
Cdd:COG3153   1 IRPATPEDAEAIAALLRAA--FGPGREA------ELVDRLREDPAAGLSLVAE--------DDGEIVGHVALSPVDIDGE 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 50344994  86 GKLLYLEDFYVMKEFRGYGMGSEILKMLSETAvktRCSGMHFIVAEWNTTSIEFYKRRG 144
Cdd:COG3153  65 GPALLLGPLAVDPEYRGQGIGRALMRAALEAA---RERGARAVVLLGDPSLLPFYERFG 120
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 73-144 1.39e-11

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 57.74  E-value: 1.39e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50344994  73 GFAMYYFTYDPWIGkllYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRG 144
Cdd:COG0456   1 GFALLGLVDGGDEA---EIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLG 69
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 4-144 2.95e-10

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 55.06  E-value: 2.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994   4 FILRKAEPKDvsdilrlIKELAKFEEMEEQVVLTEKELLEdgfgdhpfYHCVVAEVPKdnqsiegyTVVGFAMYyFTYDP 83
Cdd:COG0454   1 MSIRKATPED-------INFILLIEALDAELKAMEGSLAG--------AEFIAVDDKG--------EPIGFAGL-RRLDD 56

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50344994  84 WIGkllYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMHFIVAEWNTTSIEFYKRRG 144
Cdd:COG0454  57 KVL---ELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLG 114
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 4-159 1.47e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 53.07  E-value: 1.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994   4 FILRKAEPKDVSDILRLIKELAkfeemeeqvvltekelLEDGFGdhpfyHCVVAEVpkDNQsiegytVVGFAMYYftydP 83
Cdd:COG1246   1 MTIRPATPDDVPAILELIRPYA----------------LEEEIG-----EFWVAEE--DGE------IVGCAALH----P 47

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994  84 WIGKLLYLEDFYVMKEFRGYGMGSEILKMLSETAVKtrcSGMHFIVAEWNTTSIEFYKRRG-----ASDLSHEEGWRLYE 158
Cdd:COG1246  48 LDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARE---LGLKRLFLLTTSAAIHFYEKLGfeeidKEDLPYAKVWQRDS 124


                .
gi 50344994 159 I 159
Cdd:COG1246 125 V 125
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 50-144 3.55e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 43.21  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994    50 PFYHCVVAEvpkdnqsiEGYTVVGFAMYYFTYDPWIGKLLYLedfYVMKEFRGYGMGSEILKMLSETAvktRCSGMHFIV 129
Cdd:pfam13508   1 PGGRFFVAE--------DDGKIVGFAALLPLDDEGALAELRL---AVHPEYRGQGIGRALLEAAEAAA---KEGGIKLLE 66

                          90
                  ....*....|....*
gi 50344994   130 AEWNTTSIEFYKRRG 144
Cdd:pfam13508  67 LETTNRAAAFYEKLG 81
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 70-126 3.58e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 3.58e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 50344994  70 TVVGFAMYYFtyDPWIGKLLYLEDFYVMKEFRGYGMGSEILKMLSETAVKTRCSGMH 126
Cdd:cd04301   9 EIVGFASLSP--DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-142 1.74e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 37.29  E-value: 1.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50344994   1 MAKFILRKAEPKDVSDILRLI--KELAKF--------EEMEEQVvltekELLEDGFGDHPFYHCVVAEVPKDnqsiegyT 70
Cdd:COG1670   5 TERLRLRPLRPEDAEALAELLndPEVARYlpgppyslEEARAWL-----ERLLADWADGGALPFAIEDKEDG-------E 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50344994  71 VVGFAMYYftYDPWIGKLLYLeDFYVMKEFRGYGMGSEILKMLSETAVKTRcsGMHFIVAE---WNTTSIEFYKR 142
Cdd:COG1670  73 LIGVVGLY--DIDRANRSAEI-GYWLAPAYWGKGYATEALRALLDYAFEEL--GLHRVEAEvdpDNTASIRVLEK 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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