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Conserved domains on  [gi|2099351141|ref|NP_001006348|]
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transcription termination factor 3, mitochondrial precursor [Gallus gallus]

Protein Classification

mTERF domain-containing protein( domain architecture ID 139977)

mTERF (mitochondrial transcription termination factor) domain-containing protein may function as a transcription termination factor that binds promoter DNA and regulates mitochondrial replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mTERF super family cl47744
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 147-361 4.24e-20

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


The actual alignment was detected with superfamily member pfam02536:

Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 89.97  E-value: 4.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 147 LVHLGVDLSQVEKRQKAGQLLLTLDFEKDITKILLFLKDVGIEDNQLGPFLTKNPYILGEELEA-LETRVAYLKSKKFGN 225
Cdd:pfam02536   4 LESLGVTDSQISKILTRYPPVLHADVEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKLEEtMSTSVDFLKEIGVDK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 226 AEITQMVSRAPYLLLFSVER-LDNRLGFFKnELGLSVKKTKDLVIRFPRLLTGKL------EPVKENLQVCQvEFGFERN 298
Cdd:pfam02536  84 SSIGGALRSWPSILGMRVGNnIKNNVEYLR-ELGVPQKLLARLLISRPQLLALDLvylmkpKTFEEKVEFLK-ELGFSVE 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2099351141 299 EVQQIAFKTPKILTAS-KKRLRQTFDYLhNIMGIPHN----MLTRFPQVFNSKLLRIKERHMFLIFLG 361
Cdd:pfam02536 162 DVWKIIKKCPEILGLSiEKKLKKKIEFL-KKCGLSEEelprVIKKYPQILSLSERTILNRVEFLLGLG 228
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 147-361 4.24e-20

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 89.97  E-value: 4.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 147 LVHLGVDLSQVEKRQKAGQLLLTLDFEKDITKILLFLKDVGIEDNQLGPFLTKNPYILGEELEA-LETRVAYLKSKKFGN 225
Cdd:pfam02536   4 LESLGVTDSQISKILTRYPPVLHADVEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKLEEtMSTSVDFLKEIGVDK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 226 AEITQMVSRAPYLLLFSVER-LDNRLGFFKnELGLSVKKTKDLVIRFPRLLTGKL------EPVKENLQVCQvEFGFERN 298
Cdd:pfam02536  84 SSIGGALRSWPSILGMRVGNnIKNNVEYLR-ELGVPQKLLARLLISRPQLLALDLvylmkpKTFEEKVEFLK-ELGFSVE 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2099351141 299 EVQQIAFKTPKILTAS-KKRLRQTFDYLhNIMGIPHN----MLTRFPQVFNSKLLRIKERHMFLIFLG 361
Cdd:pfam02536 162 DVWKIIKKCPEILGLSiEKKLKKKIEFL-KKCGLSEEelprVIKKYPQILSLSERTILNRVEFLLGLG 228
PLN03196 PLN03196
MOC1-like protein; Provisional
 182-386 5.73e-09

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 57.80  E-value: 5.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 182 FLKDVGIEDNQLGPFLTKNPYILGEELE-ALETRVAYLKSKKFGNAEITQMVSRAPYLLLFSVE-RLDNRLGFFKNELGL 259
Cdd:PLN03196  238 YLESLGLPRLAVARILEKRPYILGFDLEeTVKPNVECLLEFGVRKEALPSVIAQYPDILGLDLKaKLAEQQYWLTSKLKI 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 260 SVKKTKDLVIRFPRLLTgklepVKENLQVCQVEF----GFERNEVQQIAFKTPKILTASKKRLRQTFDYLHNIMGIPHNM 335
Cdd:PLN03196  318 DPEDFGRVIEKLPQIVS-----LNRNVALKHVEFlrgrGFSAQDVAKMVVRCPQILALNLEIMKPSLEFFKKEMKRPLKE 392

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2099351141 336 LTRFPQVFNSKL-LRIKERHMFLIflgraqydpTKPSYISLDQLVSLPDEVF 386
Cdd:PLN03196  393 LVEFPAYFTYGLeSRIKPRYERVA---------KKGIKCSLAWFLNCSDDKF 435
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 147-361 4.24e-20

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 89.97  E-value: 4.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 147 LVHLGVDLSQVEKRQKAGQLLLTLDFEKDITKILLFLKDVGIEDNQLGPFLTKNPYILGEELEA-LETRVAYLKSKKFGN 225
Cdd:pfam02536   4 LESLGVTDSQISKILTRYPPVLHADVEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKLEEtMSTSVDFLKEIGVDK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 226 AEITQMVSRAPYLLLFSVER-LDNRLGFFKnELGLSVKKTKDLVIRFPRLLTGKL------EPVKENLQVCQvEFGFERN 298
Cdd:pfam02536  84 SSIGGALRSWPSILGMRVGNnIKNNVEYLR-ELGVPQKLLARLLISRPQLLALDLvylmkpKTFEEKVEFLK-ELGFSVE 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2099351141 299 EVQQIAFKTPKILTAS-KKRLRQTFDYLhNIMGIPHN----MLTRFPQVFNSKLLRIKERHMFLIFLG 361
Cdd:pfam02536 162 DVWKIIKKCPEILGLSiEKKLKKKIEFL-KKCGLSEEelprVIKKYPQILSLSERTILNRVEFLLGLG 228
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 141-386 1.97e-16

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 79.57  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 141 SETLTKLVHLGVDLSQVEKRQKAGQLLLTLDFEKDITKILLFLKDVGIEDNQLGPFLTKNPYILGEEL------EALETR 214
Cdd:pfam02536  70 STSVDFLKEIGVDKSSIGGALRSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLvylmkpKTFEEK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 215 VAYLKSKKFGNAEITQMVSRAPYLLLFSVE-RLD------NRLGFFKNELGLSVKKtkdlvirFPRLLT---GKLEPVKE 284
Cdd:pfam02536 150 VEFLKELGFSVEDVWKIIKKCPEILGLSIEkKLKkkieflKKCGLSEEELPRVIKK-------YPQILSlseRTILNRVE 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 285 NLQvcqvEFGFERNEVQQIAFKTPKILTASKKRLRQTFDYLHNIMGIPHNMLTRFPQVFNSKLL-RIKERHMFLIflgRA 363
Cdd:pfam02536 223 FLL----GLGFSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEMKWPLKEVVEYPRVFGYSLEkRIKPRIKALV---SK 295

                         250       260
                  ....*....|....*....|...
gi 2099351141 364 QYDPtkpsyiSLDQLVSLPDEVF 386
Cdd:pfam02536 296 GLEC------SLSWMLACSDERF 312
PLN03196 PLN03196
MOC1-like protein; Provisional
 182-386 5.73e-09

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 57.80  E-value: 5.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 182 FLKDVGIEDNQLGPFLTKNPYILGEELE-ALETRVAYLKSKKFGNAEITQMVSRAPYLLLFSVE-RLDNRLGFFKNELGL 259
Cdd:PLN03196  238 YLESLGLPRLAVARILEKRPYILGFDLEeTVKPNVECLLEFGVRKEALPSVIAQYPDILGLDLKaKLAEQQYWLTSKLKI 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 260 SVKKTKDLVIRFPRLLTgklepVKENLQVCQVEF----GFERNEVQQIAFKTPKILTASKKRLRQTFDYLHNIMGIPHNM 335
Cdd:PLN03196  318 DPEDFGRVIEKLPQIVS-----LNRNVALKHVEFlrgrGFSAQDVAKMVVRCPQILALNLEIMKPSLEFFKKEMKRPLKE 392

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2099351141 336 LTRFPQVFNSKL-LRIKERHMFLIflgraqydpTKPSYISLDQLVSLPDEVF 386
Cdd:PLN03196  393 LVEFPAYFTYGLeSRIKPRYERVA---------KKGIKCSLAWFLNCSDDKF 435
PLN03196 PLN03196
MOC1-like protein; Provisional
 175-357 5.38e-07

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 51.63  E-value: 5.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 175 DITKILLFLKDVGIEDNQLGPFLTKNPYILGEELEA-LETRVAYLKSKKFGNAEITQMVSRAPYLLLFSVERLDNRLGFF 253
Cdd:PLN03196  159 DLAPVVKYLQGLDVKRQDIPRVLERYPELLGFKLEGtMSTSVAYLVSIGVAPRDIGPMLTRFPEILGMRVGNNIKPKVDY 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 254 KNELGLSVKKTKDLVIRFPRLLTGKLEP-VKENLQvCQVEFGFERNEVQQIAFKTPKILTAS-KKRLRQTFDYLHNIMGI 331
Cdd:PLN03196  239 LESLGLPRLAVARILEKRPYILGFDLEEtVKPNVE-CLLEFGVRKEALPSVIAQYPDILGLDlKAKLAEQQYWLTSKLKI 317

                         170       180       190
                  ....*....|....*....|....*....|
gi 2099351141 332 PHN----MLTRFPQVFNSKLLRIKERHMFL 357
Cdd:PLN03196  318 DPEdfgrVIEKLPQIVSLNRNVALKHVEFL 347
PLN03196 PLN03196
MOC1-like protein; Provisional
 181-280 8.34e-06

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 47.78  E-value: 8.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099351141 181 LFLKDVGIEDNQLGPFLTKNPYILGEELEALETRVAYLKSKKFGNAEITQMVSRAPYLLLFSVERLDNRLGFFKNELGls 260
Cdd:PLN03196  310 WLTSKLKIDPEDFGRVIEKLPQIVSLNRNVALKHVEFLRGRGFSAQDVAKMVVRCPQILALNLEIMKPSLEFFKKEMK-- 387

                          90       100
                  ....*....|....*....|
gi 2099351141 261 vKKTKDLVIrFPRLLTGKLE 280
Cdd:PLN03196  388 -RPLKELVE-FPAYFTYGLE 405
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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