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Conserved domains on  [gi|2099395237|ref|NP_001006473|]
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ribonuclease inhibitor [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-318 1.16e-62

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 205.67  E-value: 1.16e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237   1 MDLDIQCEEMNPSRWAELLSTMKSCSTIRLDDCNLSSSNCKDLSSIIHTNPSLKELKLNNNELGdaGIEY---LCKGLLT 77
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETG--RIPRglqSLLQGLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  78 PSCSLQKLWLQNCNLTSASCETLRSVLSAqPSLTELHVGDNKLGTTGVKVLCQGLMNPNCKLQKLQLEYCELTADIVEAL 157
Cdd:cd00116    79 KGCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 158 NAALQAKPTLKELSLSNNTLGDTAVKQLCRGLvEASCDLELLHLENCGITSDSCRDISAVLSSKPSLLDLAVGDNKIGDT 237
Cdd:cd00116   158 AKALRANRDLKELNLANNGIGDAGIRALAEGL-KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 238 GLALLCQGLLHPNCKIQKLWLWDCDLTSASCKDLSRVFSTKETLLEVSLIDNNLRDSGMEMLCQALKDPKAHLQELWVRE 317
Cdd:cd00116   237 GAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316


                  .
gi 2099395237 318 C 318
Cdd:cd00116   317 D 317
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 223-421 8.78e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 94.09  E-value: 8.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 223 SLLDLAVGDNKIGDTGLALLCQGLLHPNcKIQKLWLWDCDLTSASCKDLSRVFSTKETLLEVSLIDNNLRDSGMEMLCQA 302
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 303 LKDPKAhLQELWVRECGLTAACCKAVSSVLSVNKHLQVLHIGENKLGNAGVEILCEGLLHpNCNIHSLWLGNCDITAACC 382
Cdd:COG5238   260 LKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2099395237 383 ATLANVMVTKQNLTELDLSYNTLEDEGVMKLCEA-VRNPN 421
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYlEGNTT 377
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-318 1.16e-62

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 205.67  E-value: 1.16e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237   1 MDLDIQCEEMNPSRWAELLSTMKSCSTIRLDDCNLSSSNCKDLSSIIHTNPSLKELKLNNNELGdaGIEY---LCKGLLT 77
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETG--RIPRglqSLLQGLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  78 PSCSLQKLWLQNCNLTSASCETLRSVLSAqPSLTELHVGDNKLGTTGVKVLCQGLMNPNCKLQKLQLEYCELTADIVEAL 157
Cdd:cd00116    79 KGCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 158 NAALQAKPTLKELSLSNNTLGDTAVKQLCRGLvEASCDLELLHLENCGITSDSCRDISAVLSSKPSLLDLAVGDNKIGDT 237
Cdd:cd00116   158 AKALRANRDLKELNLANNGIGDAGIRALAEGL-KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 238 GLALLCQGLLHPNCKIQKLWLWDCDLTSASCKDLSRVFSTKETLLEVSLIDNNLRDSGMEMLCQALKDPKAHLQELWVRE 317
Cdd:cd00116   237 GAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316


                  .
gi 2099395237 318 C 318
Cdd:cd00116   317 D 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-309 1.26e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 96.78  E-value: 1.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  50 NPSLKELKLNNNELGDAGIEYLCKGLLTPScSLQKLWLQNCNLTSASCETLRSVLSAQPSLTELHVGDNKLGTTGVKVLC 129
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 130 QGLMNpNCKLQKLQLEYCELTADIVEALNAALQAKPTLKELSLSNNTLGDTAVKQLCRGLvEASCDLELLHLENCGITSD 209
Cdd:COG5238   258 EALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 210 SCRDISAVLSSKPSLLDLAVGDNKIGDTGLALLCQGLlhpnckiqklwlwdcdltsasckdlsrvfSTKETLLEVSLIDN 289
Cdd:COG5238   336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL-----------------------------EGNTTLRELNLGKN 386

                         250       260
                  ....*....|....*....|
gi 2099395237 290 NLRDSGMEMLCQALKDPKAH 309
Cdd:COG5238   387 NIGKQGAEALIDALQTNRLH 406
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 223-421 8.78e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 94.09  E-value: 8.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 223 SLLDLAVGDNKIGDTGLALLCQGLLHPNcKIQKLWLWDCDLTSASCKDLSRVFSTKETLLEVSLIDNNLRDSGMEMLCQA 302
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 303 LKDPKAhLQELWVRECGLTAACCKAVSSVLSVNKHLQVLHIGENKLGNAGVEILCEGLLHpNCNIHSLWLGNCDITAACC 382
Cdd:COG5238   260 LKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2099395237 383 ATLANVMVTKQNLTELDLSYNTLEDEGVMKLCEA-VRNPN 421
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYlEGNTT 377
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 1-30 1.42e-09

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 52.89  E-value: 1.42e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2099395237   1 MDLDIQCEEMNPSRWAELLSTMKSCSTIRL 30
Cdd:pfam18779   1 MDLDIQCEELSDSRWTELLPSMQQCKVVRL 30
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 309-429 2.68e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 309 HLQELWVRECGLTAACCKAVSSVLSVNKHLQVLHIGENKLGN--AGVEILCEGLLHpNCNIHSLWLGNCDITAACCATLA 386
Cdd:cd00116    24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRipRGLQSLLQGLTK-GCGLQELDLSDNALGPDGCGVLE 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2099395237 387 NVMvTKQNLTELDLSYNTLEDEGVMKLCEAVRNPNCKMQQLIL 429
Cdd:cd00116   103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVL 144
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
50-75 9.20e-05

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 39.31  E-value: 9.20e-05
                           10        20
                   ....*....|....*....|....*.
gi 2099395237   50 NPSLKELKLNNNELGDAGIEYLCKGL 75
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_6 pfam13516
Leucine Rich repeat;
391-414 1.75e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 35.67  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|....
gi 2099395237 391 TKQNLTELDLSYNTLEDEGVMKLC 414
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
335-362 2.47e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 2.47e-03
                           10        20
                   ....*....|....*....|....*...
gi 2099395237  335 NKHLQVLHIGENKLGNAGVEILCEGLLH 362
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1-318 1.16e-62

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 205.67  E-value: 1.16e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237   1 MDLDIQCEEMNPSRWAELLSTMKSCSTIRLDDCNLSSSNCKDLSSIIHTNPSLKELKLNNNELGdaGIEY---LCKGLLT 77
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETG--RIPRglqSLLQGLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  78 PSCSLQKLWLQNCNLTSASCETLRSVLSAqPSLTELHVGDNKLGTTGVKVLCQGLMNPNCKLQKLQLEYCELTADIVEAL 157
Cdd:cd00116    79 KGCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 158 NAALQAKPTLKELSLSNNTLGDTAVKQLCRGLvEASCDLELLHLENCGITSDSCRDISAVLSSKPSLLDLAVGDNKIGDT 237
Cdd:cd00116   158 AKALRANRDLKELNLANNGIGDAGIRALAEGL-KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 238 GLALLCQGLLHPNCKIQKLWLWDCDLTSASCKDLSRVFSTKETLLEVSLIDNNLRDSGMEMLCQALKDPKAHLQELWVRE 317
Cdd:cd00116   237 GAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316


                  .
gi 2099395237 318 C 318
Cdd:cd00116   317 D 317
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 139-434 1.19e-51

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 176.78  E-value: 1.19e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 139 LQKLQLEYCELTADIVEALNAALQAKPTLKELSLS-NNTLGDTAVKQLCRGLVEASCDLELLHLENCGITSDSCRDISAV 217
Cdd:cd00116    25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSlNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 218 LSSkPSLLDLAVGDNKIGDTGLALLCQGLLHPNCKIQKLWLWDCDLTSASCKDLSRVFSTKETLLEVSLIDNNLRDSGME 297
Cdd:cd00116   105 LRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIR 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 298 MLCQALKDPKaHLQELWVRECGLTAACCKAVSSVLSVNKHLQVLHIGENKLGNAGVEILCEGLLHPNCNIHSLWLGNCDI 377
Cdd:cd00116   184 ALAEGLKANC-NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDI 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2099395237 378 TAACCATLANVMVTKQNLTELDLSYNTLEDEGVMKLCEAVRNPNCKMQQLILYDIFW 434
Cdd:cd00116   263 TDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDDSF 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 9-263 4.28e-39

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 143.65  E-value: 4.28e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237   9 EMNPSRWAELLSTMKSC---STIRLDDCNLSSSNCKDLSSIiHTNPSLKELKLNNNELGDAGIEYLCKGLLTPSCSLQKL 85
Cdd:cd00116    64 GRIPRGLQSLLQGLTKGcglQELDLSDNALGPDGCGVLESL-LRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  86 WLQNCNLTSASCETLRSVLSAQPSLTELHVGDNKLGTTGVKVLCQGLMNpNCKLQKLQLEYCELTADIVEALNAALQAKP 165
Cdd:cd00116   143 VLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLK 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 166 TLKELSLSNNTLGDTAVKQLCRGLVEASCDLELLHLENCGITSDSCRDISAVLSSKPSLLDLAVGDNKIGDTGLALLCQG 245
Cdd:cd00116   222 SLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301

                         250
                  ....*....|....*...
gi 2099395237 246 LLHPNCKIQKLWLWDCDL 263
Cdd:cd00116   302 LLEPGNELESLWVKDDSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-309 1.26e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 96.78  E-value: 1.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  50 NPSLKELKLNNNELGDAGIEYLCKGLLTPScSLQKLWLQNCNLTSASCETLRSVLSAQPSLTELHVGDNKLGTTGVKVLC 129
Cdd:COG5238   179 NNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 130 QGLMNpNCKLQKLQLEYCELTADIVEALNAALQAKPTLKELSLSNNTLGDTAVKQLCRGLvEASCDLELLHLENCGITSD 209
Cdd:COG5238   258 EALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 210 SCRDISAVLSSKPSLLDLAVGDNKIGDTGLALLCQGLlhpnckiqklwlwdcdltsasckdlsrvfSTKETLLEVSLIDN 289
Cdd:COG5238   336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL-----------------------------EGNTTLRELNLGKN 386

                         250       260
                  ....*....|....*....|
gi 2099395237 290 NLRDSGMEMLCQALKDPKAH 309
Cdd:COG5238   387 NIGKQGAEALIDALQTNRLH 406
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 223-421 8.78e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 94.09  E-value: 8.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 223 SLLDLAVGDNKIGDTGLALLCQGLLHPNcKIQKLWLWDCDLTSASCKDLSRVFSTKETLLEVSLIDNNLRDSGMEMLCQA 302
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 303 LKDPKAhLQELWVRECGLTAACCKAVSSVLSVNKHLQVLHIGENKLGNAGVEILCEGLLHpNCNIHSLWLGNCDITAACC 382
Cdd:COG5238   260 LKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2099395237 383 ATLANVMVTKQNLTELDLSYNTLEDEGVMKLCEA-VRNPN 421
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYlEGNTT 377
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 13-248 1.28e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.54  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  13 SRWAELLSTMKSCSTIRLDDCNLSSSNCKDLSSIIHTNPSLKELKLNNNELGDAGIEYLCKGLLTPScSLQKLWLQNCNL 92
Cdd:COG5238   198 EELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT-TVETLYLSGNQI 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  93 TSASCETLRSVLSAQPSLTELHVGDNKLGTTGVKVLCQGLMNpNCKLQKLQLEYCELTADIVEALNAALQAKPTLKELSL 172
Cdd:COG5238   277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDL 355

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2099395237 173 SNNTLGDTAVKQLCRGLVeascdlellhlencgitsdscrdisavlsSKPSLLDLAVGDNKIGDTGLALLCQGLLH 248
Cdd:COG5238   356 SDNQIGDEGAIALAKYLE-----------------------------GNTTLRELNLGKNNIGKQGAEALIDALQT 402
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 134-453 3.88e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 83.30  E-value: 3.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 134 NPNCKLQKLQLEYCELTADIVEALNAALQAKPTLKELSLSNNTLGDTAVKQLcrglveascdlellhlencgitsdscrd 213
Cdd:COG5238   177 LQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEIL---------------------------- 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 214 iSAVLSSKPSLLDLAVGDNKIGDTGLALLCQGLLHPnckiqklwlwdcdltsasckdlsrvfSTKETLlevSLIDNNLRD 293
Cdd:COG5238   229 -AEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNN--------------------------TTVETL---YLSGNQIGA 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 294 SGMEMLCQALKDPKaHLQELWVRECGLTAACCKAVSSVLSVNKHLQVLHIGENKLGNAGVEILCEGlLHPNCNIHSLWLG 373
Cdd:COG5238   279 EGAIALAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKA-LQENTTLHSLDLS 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 374 NCDITAACCATLANVMVTKQNLTELDLSYNTLEDEGVMKLCEAVrnpncKMQQLILYDIFWGPEVDDELKALEEARPDVK 453
Cdd:COG5238   357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-----QTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 1-30 1.42e-09

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 52.89  E-value: 1.42e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 2099395237   1 MDLDIQCEEMNPSRWAELLSTMKSCSTIRL 30
Cdd:pfam18779   1 MDLDIQCEELSDSRWTELLPSMQQCKVVRL 30
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 309-429 2.68e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 309 HLQELWVRECGLTAACCKAVSSVLSVNKHLQVLHIGENKLGN--AGVEILCEGLLHpNCNIHSLWLGNCDITAACCATLA 386
Cdd:cd00116    24 CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRipRGLQSLLQGLTK-GCGLQELDLSDNALGPDGCGVLE 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2099395237 387 NVMvTKQNLTELDLSYNTLEDEGVMKLCEAVRNPNCKMQQLIL 429
Cdd:cd00116   103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVL 144
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-258 4.96e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 4.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  34 NLSSSNCKDLSSIIHTNPSLKELKLNNNELGDAGIEylckglLTPSCSLQKLWLQNCNLTSascetLRSVLSAQPSLTEL 113
Cdd:COG4886   119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP------LGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKEL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 114 HVGDNKLgTTGVKVLCQglmnpNCKLQKLQLEYCELTadiveALNAALQAKPTLKELSLSNNTLGD-TAVKQLCRglvea 192
Cdd:COG4886   188 DLSNNQI-TDLPEPLGN-----LTNLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQLTDlPELGNLTN----- 251

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2099395237 193 scdLELLHLENCGITsdscrDISAvLSSKPSLLDLAVGDNKIGDTGLALLCQGLLHPNCKIQKLWL 258
Cdd:COG4886   252 ---LEELDLSNNQLT-----DLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-250 1.21e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237  30 LDDCNLSSSNCKDLSSIIHTNPSLKELKLNNNELGDAGIEylckglLTPSCSLQKLWLQNCNLTSASCEtlrsvLSAQPS 109
Cdd:COG4886   161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP------LGNLTNLEELDLSGNQLTDLPEP-----LANLTN 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395237 110 LTELHVGDNKLgtTGVKVLCQglmnpNCKLQKLQLEYCELTaDIVEALNAalqakPTLKELSLSNNTLGDTAVKQLCRGL 189
Cdd:COG4886   230 LETLDLSNNQL--TDLPELGN-----LTNLEELDLSNNQLT-DLPPLANL-----TNLKTLDLSNNQLTDLKLKELELLL 296

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2099395237 190 VEASCDLELLHLENCGITSDSCRDISAVLSSKPSLLDLAVGDNKIGDTGLALLCQGLLHPN 250
Cdd:COG4886   297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
50-75 9.20e-05

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 39.31  E-value: 9.20e-05
                           10        20
                   ....*....|....*....|....*.
gi 2099395237   50 NPSLKELKLNNNELGDAGIEYLCKGL 75
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_6 pfam13516
Leucine Rich repeat;
391-414 1.75e-03

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 35.67  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|....
gi 2099395237 391 TKQNLTELDLSYNTLEDEGVMKLC 414
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
335-362 2.47e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 2.47e-03
                           10        20
                   ....*....|....*....|....*...
gi 2099395237  335 NKHLQVLHIGENKLGNAGVEILCEGLLH 362
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
164-189 6.03e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 6.03e-03
                           10        20
                   ....*....|....*....|....*.
gi 2099395237  164 KPTLKELSLSNNTLGDTAVKQLCRGL 189
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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