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Conserved domains on  [gi|238550167|ref|NP_001008501|]
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zinc finger protein 760 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-50 8.33e-21

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 8.33e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 238550167     8 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSVEKH 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-581 1.16e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 206 KPWKCKECGKSFKWLSHLKAHCRIHTGEKPFKCN--ECDKGFSRLSRLKSHYRTHTGEKPYKCEECG------KCFSRLS 277
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 278 RLKNHYRIHTGEKPYKCKECGKSFTHCTGLST--HQKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREK--------- 346
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlsllissn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 347 ---PYKCKECGKFFHWLSGLKSHYRIHT---GETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTALK 420
Cdd:COG5048  192 vstSIPSSSENSPLSSSYSIPSSSSDQNlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 421 RHQKIHTDE-------KPYKCEECSKCFYVLSHLKSHCRT--HTGE--KPYKCEE--CGKCLSQLSKLKSHYRIHTGEKP 487
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 488 YKCK--ECDKSFTHC-----TALSTHQKIHTGEKPYSC--KDCGKSFYLLSRLKEHYRVHTGEKPYNCK--ECGKFFHWL 556
Cdd:COG5048  352 AKEKllNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420
                 ....*....|....*....|....*
gi 238550167 557 SNLKRHSRIHTGEKPYKCEECDKSF 581
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 568-618 1.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238550167 568 GEKPYKCE--ECDKSFTHCSSLKAH-------QKIH------------AGVKPYKCEECSKSFYWLSNLKTH 618
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-639 2.01e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 238550167  614 NLKTHSRIHTGEKPYKCGKCDKSFTQ 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-50 8.33e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 8.33e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 238550167     8 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSVEKH 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 1.64e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.64e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238550167    7 LLTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSV 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 3.92e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 3.92e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 238550167   8 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVS 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-581 1.16e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 206 KPWKCKECGKSFKWLSHLKAHCRIHTGEKPFKCN--ECDKGFSRLSRLKSHYRTHTGEKPYKCEECG------KCFSRLS 277
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 278 RLKNHYRIHTGEKPYKCKECGKSFTHCTGLST--HQKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREK--------- 346
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlsllissn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 347 ---PYKCKECGKFFHWLSGLKSHYRIHT---GETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTALK 420
Cdd:COG5048  192 vstSIPSSSENSPLSSSYSIPSSSSDQNlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 421 RHQKIHTDE-------KPYKCEECSKCFYVLSHLKSHCRT--HTGE--KPYKCEE--CGKCLSQLSKLKSHYRIHTGEKP 487
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 488 YKCK--ECDKSFTHC-----TALSTHQKIHTGEKPYSC--KDCGKSFYLLSRLKEHYRVHTGEKPYNCK--ECGKFFHWL 556
Cdd:COG5048  352 AKEKllNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420
                 ....*....|....*....|....*
gi 238550167 557 SNLKRHSRIHTGEKPYKCEECDKSF 581
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 568-618 1.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238550167 568 GEKPYKCE--ECDKSFTHCSSLKAH-------QKIH------------AGVKPYKCEECSKSFYWLSNLKTH 618
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 238550167  558 NLKRHSRIHTGEKPYKCEECDKSFTH 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-639 2.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 238550167  614 NLKTHSRIHTGEKPYKCGKCDKSFTQ 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-50 8.33e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 8.33e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 238550167     8 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSVEKH 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 1.64e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.64e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238550167    7 LLTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVSV 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 3.92e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 3.92e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 238550167   8 LTFGDVALDFSQEEWECLDSAQRALYIDVMLENYINLVS 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-581 1.16e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 206 KPWKCKECGKSFKWLSHLKAHCRIHTGEKPFKCN--ECDKGFSRLSRLKSHYRTHTGEKPYKCEECG------KCFSRLS 277
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 278 RLKNHYRIHTGEKPYKCKECGKSFTHCTGLST--HQKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREK--------- 346
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIsnLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlsllissn 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 347 ---PYKCKECGKFFHWLSGLKSHYRIHT---GETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTALK 420
Cdd:COG5048  192 vstSIPSSSENSPLSSSYSIPSSSSDQNlenSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 421 RHQKIHTDE-------KPYKCEECSKCFYVLSHLKSHCRT--HTGE--KPYKCEE--CGKCLSQLSKLKSHYRIHTGEKP 487
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 488 YKCK--ECDKSFTHC-----TALSTHQKIHTGEKPYSC--KDCGKSFYLLSRLKEHYRVHTGEKPYNCK--ECGKFFHWL 556
Cdd:COG5048  352 AKEKllNSSSKFSPLlnnepPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420
                 ....*....|....*....|....*
gi 238550167 557 SNLKRHSRIHTGEKPYKCEECDKSF 581
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-651 1.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 262 KPYKCEECGKCFSRLSRLKNHYRIHTGEKPYKC--KECGKSFTHCTGLSTHQKIHTGEKPHKC-KNCGKSFHLLSTLKEH 338
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 339 FRVHTREKPYKCKECGkffhwLSGLKSHYRIHTGETPYKCKECDKSFSQLSRLKSHYRTHTGEKSCKCLECDKYFTQCTA 418
Cdd:COG5048  112 SSSSNSNDNNLLSSHS-----LPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 419 LKRHQKIHTDEKPYKCEECSKcFYVLSHLKSHCRTHTGEKPYKCEECGKCLSQLSKLKSHYRIHTGEKPYKCKECDKSFT 498
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 499 HCTALSTHQKIHTGE-------KPYSCKDCGKSFYLLSRLKEHYR--VHTGE--KPYNCKE--CGKFFHWLSNLKRHSRI 565
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 566 HTGEKPYKC--EECDKSFTHCSSLKAHQKIHA--GVKPYKCEECSKSFYWL-----SNLKTHSRIHTGEKPY--KCGKCD 634
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykDLKNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPYncKNPPCS 425

                        410
                 ....*....|....*..
gi 238550167 635 KSFTQRSLLTKHNRIHT 651
Cdd:COG5048  426 KSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-646 1.26e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 234 KPFKCNECDKGFSRLSRLKSHYRTHTGEKPYKC--EECGKCFSRLSRLKNHYRIHTGEKPYKC-KECGKSFTHCTGLSTH 310
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 311 QKIHTGEKPHKCKNCGKSFHLLSTLKEHFRVHTREKPYKCKECGKFFHWLSG-LKSHYRIHTGETpykckeCDKSFSQLS 389
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 390 RLKSHYRTHTGEKSCKCLECDKYftqcTALKRHQKIHTDEKPYKCEECSKCFYVLSHLKSHCRTHTGEKPYKCEECGKCL 469
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSS----YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 470 S-----QLSKLKSHYRIHTGE-----KPYKCKECDKSFTHCTALSTHQ--KIHTGE--KPYSC--KDCGKSFYLLSRLKE 533
Cdd:COG5048  262 RsslptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 534 HYRVHTGEKPYNCK--ECGKFFHWLSNLKRHSRI--HTGEKPYKCEECDKSFT-------HCSSLKAHQKIHAGVKPYKC 602
Cdd:COG5048  342 HILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCirnfkrdSNLSLHIITHLSFRPYNCKN 421

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 238550167 603 EECSKSFYWLSNLKTHSRIHTGEKPYKCgkCDKSFTQRSLLTKH 646
Cdd:COG5048  422 PPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 568-618 1.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238550167 568 GEKPYKCE--ECDKSFTHCSSLKAH-------QKIH------------AGVKPYKCEECSKSFYWLSNLKTH 618
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 238550167  558 NLKRHSRIHTGEKPYKCEECDKSFTH 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 372-455 1.77e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 372 GETPYKCK--ECDKSFSQLSRLKSHyRTHTgeksckclECDKYFTQCTALKRHQKIHTDEKPYKCEECSKCFYVLSHLKS 449
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 238550167 450 HcRTHT 455
Cdd:COG5189  417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 288-366 4.36e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 288 GEKPYKCK--ECGKSFTHCTGLSTHqKIHtgekphkcKNCGKSFHLLSTLKEHFRVHTREKPYKCKECGKFFHWLSGLKS 365
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 238550167 366 H 366
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-499 1.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|....*
gi 238550167  475 LKSHYRIHTGEKPYKCKECDKSFTH 499
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-303 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 238550167  278 RLKNHYRIHTGEKPYKCKECGKSFTH 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-639 2.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 238550167  614 NLKTHSRIHTGEKPYKCGKCDKSFTQ 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-275 2.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 238550167  250 RLKSHYRTHTGEKPYKCEECGKCFSR 275
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
222-247 3.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 238550167  222 HLKAHCRIHTGEKPFKCNECDKGFSR 247
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 4.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....*
gi 238550167  363 LKSHYRIHTGETPYKCKECDKSFSQ 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 456-539 6.28e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238550167 456 GEKPYKCE--ECGKCLSQLSKLKSHyRIHtgekpykcKECDKSFTHCTALSTHQKIHTGEKPYSCKDCGKSFYLLSRLKE 533
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 238550167 534 HyRVHT 539
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-467 9.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.33e-03
                          10        20
                  ....*....|....*....|..
gi 238550167  446 HLKSHCRTHTGEKPYKCEECGK 467
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGK 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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