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Conserved domains on  [gi|59797063|ref|NP_001010844|]
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interleukin-1 receptor-associated kinase 1-binding protein 1 [Homo sapiens]

Protein Classification

SIMPL domain-containing protein( domain architecture ID 10516460)

SIMPL domain-containing protein similar to Homo sapiens interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1), a component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival

CATH:  3.30.70.2970|3.30.110.170
PubMed:  11096118
SCOP:  4004729

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 53-197 9.19e-21

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


:

Pssm-ID: 461292  Cd Length: 159  Bit Score: 85.82  E-value: 9.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063    53 VQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQ-QQGVQAENITVT----------KDFRRVENA 121
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKkAAGIPEKDIQTSgyslypvydyKNGKRKITG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59797063   122 YHMEAEVCITFTEFGKMQNICNFLVEKldSSVVISPPQFyhTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTL 197
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEA--GANRIDGVSF--SLSDEDELRAEARAEAVADARAKAEALAKALGLKL 152
 
Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 53-197 9.19e-21

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


Pssm-ID: 461292  Cd Length: 159  Bit Score: 85.82  E-value: 9.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063    53 VQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQ-QQGVQAENITVT----------KDFRRVENA 121
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKkAAGIPEKDIQTSgyslypvydyKNGKRKITG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59797063   122 YHMEAEVCITFTEFGKMQNICNFLVEKldSSVVISPPQFyhTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTL 197
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEA--GANRIDGVSF--SLSDEDELRAEARAEAVADARAKAEALAKALGLKL 152
YggE COG2968
Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function ...
 41-206 1.71e-15

Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function unknown];


Pssm-ID: 442208  Cd Length: 234  Bit Score: 73.39  E-value: 1.71e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063  41 LSSTQAQTAT---REVQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGV-----QAENITVT 112
Cdd:COG2968  15 LAGAPAQAEApdePTITVSGEGEVEVAPDIATVSLGVETEGKTAAEALAENAERMAAVIAALKAAGIaeediQTSNLSVQ 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063 113 KDFRRVENA------YHMEAEVCITFTEFGKMQNIcnflvekLDSSV-----VISPPQFYHTPgsVENLRRQACLVAVEN 181
Cdd:COG2968  95 PEYDYDKDGkpkltgYRASNTVTVTVRDLDKLGEV-------LDAAVaaganRINGVSFGLSD--PEALRDEARKAAVAD 165

                       170       180
                ....*....|....*....|....*
gi 59797063 182 AWRKAQEVCNLVGQTLGKPLLIKEE 206
Cdd:COG2968 166 ARAKAEALAKALGVKLGRVLSISEG 190
PRK11087 PRK11087
oxidative stress defense protein; Provisional
 53-199 9.63e-08

oxidative stress defense protein; Provisional


Pssm-ID: 236840  Cd Length: 231  Bit Score: 51.47  E-value: 9.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063   53 VQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVT-----------KDFRRVENA 121
Cdd:PRK11087  25 IVTSGTASVDAVPDMATLAVEVNVSAKDAATAKKQVDERVAQYLAFLEKNGIAKKDISSAnlrtqpqydyqKDGKSELKG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063  122 YHMEAEVCITFTEFGKMQNIcnflvekLDS----------SVV--ISPPQFYhtpgsvenlRRQACLVAVENAWRKAQEV 189
Cdd:PRK11087 105 YRASRQVTVTVRQLDKLNSL-------LDGalkaglneirSIElgVSKPDEY---------KDKARKAAIKDAIQQAQSL 168

                        170
                 ....*....|
gi 59797063  190 CNLVGQTLGK 199
Cdd:PRK11087 169 AKGFGEKLGP 178
 
Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 53-197 9.19e-21

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


Pssm-ID: 461292  Cd Length: 159  Bit Score: 85.82  E-value: 9.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063    53 VQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQ-QQGVQAENITVT----------KDFRRVENA 121
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKkAAGIPEKDIQTSgyslypvydyKNGKRKITG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59797063   122 YHMEAEVCITFTEFGKMQNICNFLVEKldSSVVISPPQFyhTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTL 197
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEA--GANRIDGVSF--SLSDEDELRAEARAEAVADARAKAEALAKALGLKL 152
YggE COG2968
Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function ...
 41-206 1.71e-15

Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function unknown];


Pssm-ID: 442208  Cd Length: 234  Bit Score: 73.39  E-value: 1.71e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063  41 LSSTQAQTAT---REVQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGV-----QAENITVT 112
Cdd:COG2968  15 LAGAPAQAEApdePTITVSGEGEVEVAPDIATVSLGVETEGKTAAEALAENAERMAAVIAALKAAGIaeediQTSNLSVQ 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063 113 KDFRRVENA------YHMEAEVCITFTEFGKMQNIcnflvekLDSSV-----VISPPQFYHTPgsVENLRRQACLVAVEN 181
Cdd:COG2968  95 PEYDYDKDGkpkltgYRASNTVTVTVRDLDKLGEV-------LDAAVaaganRINGVSFGLSD--PEALRDEARKAAVAD 165

                       170       180
                ....*....|....*....|....*
gi 59797063 182 AWRKAQEVCNLVGQTLGKPLLIKEE 206
Cdd:COG2968 166 ARAKAEALAKALGVKLGRVLSISEG 190
PRK11087 PRK11087
oxidative stress defense protein; Provisional
 53-199 9.63e-08

oxidative stress defense protein; Provisional


Pssm-ID: 236840  Cd Length: 231  Bit Score: 51.47  E-value: 9.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063   53 VQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVT-----------KDFRRVENA 121
Cdd:PRK11087  25 IVTSGTASVDAVPDMATLAVEVNVSAKDAATAKKQVDERVAQYLAFLEKNGIAKKDISSAnlrtqpqydyqKDGKSELKG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59797063  122 YHMEAEVCITFTEFGKMQNIcnflvekLDS----------SVV--ISPPQFYhtpgsvenlRRQACLVAVENAWRKAQEV 189
Cdd:PRK11087 105 YRASRQVTVTVRQLDKLNSL-------LDGalkaglneirSIElgVSKPDEY---------KDKARKAAIKDAIQQAQSL 168

                        170
                 ....*....|
gi 59797063  190 CNLVGQTLGK 199
Cdd:PRK11087 169 AKGFGEKLGP 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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