NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|61656194|ref|NP_001013408|]
View 

sodium channel subunit beta-4 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 31-151 1.24e-13

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05715:

Pssm-ID: 472250  Cd Length: 117  Bit Score: 65.14  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  31 LEVSVGKatTIYAINGSSILLPCTFSSCYGFENLY-FKWSY-----NNSETSRILIDGIVKNDKSDPKvrvkdDDRITLE 104
Cdd:cd05715   1 MEVYTPR--ELNVLNGSDVRLTCTFTSCYTVGDAFsVTWTYqpeggNTTESMFHYSKGKPYILKVGRF-----KDRVSWA 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61656194 105 GSTKEKtnNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSaTIFLQV 151
Cdd:cd05715  74 GNPSKK--DASIVISNLQFSDNGTYTCDVKNPPDIVGGHG-EIRLYV 117
 
Name Accession Description Interval E-value
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 31-151 1.24e-13

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 65.14  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  31 LEVSVGKatTIYAINGSSILLPCTFSSCYGFENLY-FKWSY-----NNSETSRILIDGIVKNDKSDPKvrvkdDDRITLE 104
Cdd:cd05715   1 MEVYTPR--ELNVLNGSDVRLTCTFTSCYTVGDAFsVTWTYqpeggNTTESMFHYSKGKPYILKVGRF-----KDRVSWA 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61656194 105 GSTKEKtnNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSaTIFLQV 151
Cdd:cd05715  74 GNPSKK--DASIVISNLQFSDNGTYTCDVKNPPDIVGGHG-EIRLYV 117
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-138 4.25e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 49.76  E-value: 4.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194    45 NGSSILLPCTFSSCYGFENLYFKWSYNNSETS-RILIdgIVKNDKSDPKVrvkDDDRITLEGSTKEktNNISILLSDLEF 123
Cdd:pfam07686  10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGpTFLI--AYYSNGSEEGV---KKGRFSGRGDPSN--GDGSLTIQNLTL 82

                          90
                  ....*....|....*
gi 61656194   124 SDTGRYTCFVRNPKE 138
Cdd:pfam07686  83 SDSGTYTCAVIPSGE 97
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 40-151 2.32e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.42  E-value: 2.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194     40 TIYAINGSSILLPCTFSscyGFENLYFKWSYNNSETsrilidgivkndksdpkvrVKDDDRITLEGSTkektNNISILLS 119
Cdd:smart00410   3 SVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKL-------------------LAESGRFSVSRSG----STSTLTIS 56

                           90       100       110
                   ....*....|....*....|....*....|..
gi 61656194    120 DLEFSDTGRYTCFVRNPKEKDlnnSATIFLQV 151
Cdd:smart00410  57 NVTPEDSGTYTCAATNSSGSA---SSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 31-151 1.24e-13

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 65.14  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  31 LEVSVGKatTIYAINGSSILLPCTFSSCYGFENLY-FKWSY-----NNSETSRILIDGIVKNDKSDPKvrvkdDDRITLE 104
Cdd:cd05715   1 MEVYTPR--ELNVLNGSDVRLTCTFTSCYTVGDAFsVTWTYqpeggNTTESMFHYSKGKPYILKVGRF-----KDRVSWA 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61656194 105 GSTKEKtnNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSaTIFLQV 151
Cdd:cd05715  74 GNPSKK--DASIVISNLQFSDNGTYTCDVKNPPDIVGGHG-EIRLYV 117
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
 41-140 7.92e-09

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 52.14  E-value: 7.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  41 IYAINGSSILLPCTFSSCYGF-ENLYFKWSYNNSETSRiliDGIV----KNDKSDPKVRVKDddRITLEGSTKEktNNIS 115
Cdd:cd05880   9 VEAVNGTDVRLKCTFSSSAPIgDTLVITWNFRPLDGGR---EESVfyyhKRPYPPPDGRFKG--RVVWDGNIMR--RDAS 81

                        90       100
                ....*....|....*....|....*
gi 61656194 116 ILLSDLEFSDTGRYTCFVRNPKEKD 140
Cdd:cd05880  82 ILIWQLQPTDNGTYTCQVKNPPDVH 106
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-138 4.25e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 49.76  E-value: 4.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194    45 NGSSILLPCTFSSCYGFENLYFKWSYNNSETS-RILIdgIVKNDKSDPKVrvkDDDRITLEGSTKEktNNISILLSDLEF 123
Cdd:pfam07686  10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGpTFLI--AYYSNGSEEGV---KKGRFSGRGDPSN--GDGSLTIQNLTL 82

                          90
                  ....*....|....*
gi 61656194   124 SDTGRYTCFVRNPKE 138
Cdd:pfam07686  83 SDSGTYTCAVIPSGE 97
IgV_P0 cd05879
Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the ...
 41-151 6.41e-08

Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin.


Pssm-ID: 409463  Cd Length: 117  Bit Score: 49.49  E-value: 6.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  41 IYAINGSSILLPCTF-SSCYGFENLYFKWSYNnSETSRILIDgIVKNDKSDPKVRVKD--DDRITLEGSTKEKtnNISIL 117
Cdd:cd05879   9 VYGTVGSDVTLSCSFwSSEWISDDISFTWHYQ-PDGSRDAIS-IFHYGKGQPYIDNVGpfKERIEWVGNPSRK--DGSIV 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 61656194 118 LSDLEFSDTGRYTCFVRNPKEKdLNNSATIFLQV 151
Cdd:cd05879  85 IHNLDYTDNGTFTCDVKNPPDI-VGKSSQVTLYV 117
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 40-151 2.32e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.42  E-value: 2.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194     40 TIYAINGSSILLPCTFSscyGFENLYFKWSYNNSETsrilidgivkndksdpkvrVKDDDRITLEGSTkektNNISILLS 119
Cdd:smart00410   3 SVTVKEGESVTLSCEAS---GSPPPEVTWYKQGGKL-------------------LAESGRFSVSRSG----STSTLTIS 56

                           90       100       110
                   ....*....|....*....|....*....|..
gi 61656194    120 DLEFSDTGRYTCFVRNPKEKDlnnSATIFLQV 151
Cdd:smart00410  57 NVTPEDSGTYTCAATNSSGSA---SSGTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
51-133 8.07e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 42.75  E-value: 8.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194     51 LPCTFSScYGFENLYFKWSY--NNSETSRILIDGIVKNDKSDPKVRvkddDRITLEGSTKekTNNISILLSDLEFSDTGR 128
Cdd:smart00406   4 LSCKFSG-STFSSYYVSWVRqpPGKGLEWLGYIGSNGSSYYQESYK----GRFTISKDTS--KNDVSLTISNLRVEDTGT 76


                   ....*
gi 61656194    129 YTCFV 133
Cdd:smart00406  77 YYCAV 81
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 41-151 2.78e-04

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 39.51  E-value: 2.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  41 IYAINGSSILLPCTFSSCYGF--ENLYFKWSYNNSETsriLIDGIVKNDKSDPKVRVKDDDRITLeGSTKEKTNNISILL 118
Cdd:cd20934   7 VVALVGTDATLRCSFSPEPGFslAQLSVFWQLTDTKQ---LVHSFTESQDQGRDQGSAYANRTAL-FPDLLAQGNASLRL 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 61656194 119 SDLEFSDTGRYTCFVRNPKekdlNNSATIFLQV 151
Cdd:cd20934  83 QRVRVADEGSYTCFVSVQD----FGSAAVSLQV 111
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 48-152 5.89e-04

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 38.28  E-value: 5.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  48 SILLPCTFSSCYGFENLYFKWSY--NNSETSRILIDGivkndKSDPKVRVKDDDRITLegsTKEKTNNISILLSDLEFSD 125
Cdd:cd16089  16 SVNLPCTYVPEEGYTQVLVKWLVqrDSDPVTIFLRDS-----SGDHIQQAKYRGRLEV---SKDTPGDVSLQLDTLEMDD 87

                        90       100
                ....*....|....*....|....*....
gi 61656194 126 TGRYTCFV--RNPKEKDLNNSATIFLQVV 152
Cdd:cd16089  88 RGHYTCQVtwQTPDGNLIVREKTTELRVQ 116
I-set pfam07679
Immunoglobulin I-set domain;
46-151 8.43e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 37.24  E-value: 8.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194    46 GSSILLPCTFSscyGFENLYFKWSYNNSETsrilidgivkndKSDPKVRVK-DDDRITLEgstkektnnisilLSDLEFS 124
Cdd:pfam07679  15 GESARFTCTVT---GTPDPEVSWFKDGQPL------------RSSDRFKVTyEGGTYTLT-------------ISNVQPD 66

                          90       100
                  ....*....|....*....|....*..
gi 61656194   125 DTGRYTCFVRNPKEKDlnnSATIFLQV 151
Cdd:pfam07679  67 DSGKYTCVATNSAGEA---EASAELTV 90
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 38-139 1.39e-03

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 37.19  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  38 ATTIYAINGSSILLPCTFSSCYGFENLYFKWsynnsetSRILIDGIV------KNDKSD--PKVRVKdddriTLEGSTKE 109
Cdd:cd20984   4 AKHLAGNIGEDGILSCTFTPDIKLSDIVIQW-------LKEGDSGLVhefkegKDELSRqsPMFRGR-----TSLFADQV 71

                        90       100       110
                ....*....|....*....|....*....|
gi 61656194 110 KTNNISILLSDLEFSDTGRYTCFVRNPKEK 139
Cdd:cd20984  72 HVGNASLRLKNVQLTDAGTYLCIISNSKGT 101
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 39-135 9.93e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 34.73  E-value: 9.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656194  39 TTIYAINGSSILLPCTFS-SCYGFENLYFKWSYNNSE-TSRILI---DGIVKNDKSDP-KVRVkdddritlEGSTKEKTN 112
Cdd:cd20960   8 TEIKKVAGENVTLPCHHQlGLEDQGTLDIEWLLLPSDkVEKVVItysGDRVYNHYYPAlKGRV--------AFTSNDLSG 79

                        90       100
                ....*....|....*....|...
gi 61656194 113 NISILLSDLEFSDTGRYTCFVRN 135
Cdd:cd20960  80 DASLNISNLKLSDTGTYQCKVKK 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH