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Conserved domains on  [gi|61966713|ref|NP_001013650|]
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DDB1- and CUL4-associated factor 12-like protein 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-293 3.57e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 3.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 109 RQVVCGTKCNTLFVVDVQSGHITRIPlmrdkeaglaQAHQGcGIHAIELNPSKTLLATGGENpNSLAIYQLPTldPLCLG 188
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTL----------TGHSG-SVRSVAFSPDGRLLASGSAD-GTVRLWDLAT--GELLR 282
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 189 DRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALWRMD----------PDMFNGSIAWhSEVGLPVYA-----HIRPRDVE- 251
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDgKLLASGSDDGTVRLWDLAtgkllrtltgHTGAVRSVAF-SPDGKTLASgsddgTVRLWDLAt 361
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 61966713 252 -AIPRASTNPSNRkVRALAFSGKNQELGAVSLDGYFHLWKARS 293
Cdd:COG2319 362 gELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-293 3.57e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 3.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 109 RQVVCGTKCNTLFVVDVQSGHITRIPlmrdkeaglaQAHQGcGIHAIELNPSKTLLATGGENpNSLAIYQLPTldPLCLG 188
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTL----------TGHSG-SVRSVAFSPDGRLLASGSAD-GTVRLWDLAT--GELLR 282
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 189 DRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALWRMD----------PDMFNGSIAWhSEVGLPVYA-----HIRPRDVE- 251
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDgKLLASGSDDGTVRLWDLAtgkllrtltgHTGAVRSVAF-SPDGKTLASgsddgTVRLWDLAt 361
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 61966713 252 -AIPRASTNPSNRkVRALAFSGKNQELGAVSLDGYFHLWKARS 293
Cdd:COG2319 362 gELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
95-381 9.65e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 9.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713  95 GTLNKVFASQWLNARQVVC-GTKCNTLFVVDVQSGHITRIPlmrdkeaglaQAHQGcGIHAIELNPSKTLLATGGENpNS 173
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTL----------KGHTG-PVRDVAASADGTYLASGSSD-KT 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 174 LAIYQLPTLDplCLGDRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALWRMDPDMFNGSIAWHSEVglpvyahirprdvea 252
Cdd:cd00200  75 IRLWDLETGE--CVRTLTGHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW--------------- 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 253 iprastnpsnrkVRALAFSGKNQELGAVSLDGYFHLWKARS-TLSRLLSIRLPYCRenvCLTYCDELSLYAVGSQSHVSF 331
Cdd:cd00200 138 ------------VNSVAFSPDGTFVASSSQDGTIKLWDLRTgKCVATLTGHTGEVN---SVAFSPDGEKLLSSSSDGTIK 202
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 61966713 332 L-DPRQRQQnirpLCSREG-GTGVRSLSFYQH--IITVGTGHGSLLFYDIRAQK 381
Cdd:cd00200 203 LwDLSTGKC----LGTLRGhENGVNSVAFSPDgyLLASGSEDGTIRVWDLRTGE 252
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
186-220 3.53e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 61966713    186 CLGDRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALW 220
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
186-220 7.79e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61966713   186 CLGDRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALW 220
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-293 3.57e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 3.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 109 RQVVCGTKCNTLFVVDVQSGHITRIPlmrdkeaglaQAHQGcGIHAIELNPSKTLLATGGENpNSLAIYQLPTldPLCLG 188
Cdd:COG2319 217 KLLASGSADGTVRLWDLATGKLLRTL----------TGHSG-SVRSVAFSPDGRLLASGSAD-GTVRLWDLAT--GELLR 282
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 189 DRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALWRMD----------PDMFNGSIAWhSEVGLPVYA-----HIRPRDVE- 251
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDgKLLASGSDDGTVRLWDLAtgkllrtltgHTGAVRSVAF-SPDGKTLASgsddgTVRLWDLAt 361
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 61966713 252 -AIPRASTNPSNRkVRALAFSGKNQELGAVSLDGYFHLWKARS 293
Cdd:COG2319 362 gELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
20-293 8.02e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 8.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713  20 AGSSSSQGLAAADGEGPLLPKKQKRPATRRRLVHYLKGREVGARGPAGLQGFEGELRGYAVQRLPELLTERQLDLGTLNK 99
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 100 VFASQWL-NARQVVCGTKCNTLFVVDVQSGHITRIPlmrdkeaglaQAHQGcGIHAIELNPSKTLLATGGENpNSLAIYQ 178
Cdd:COG2319  81 VLSVAFSpDGRLLASASADGTVRLWDLATGLLLRTL----------TGHTG-AVRSVAFSPDGKTLASGSAD-GTVRLWD 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 179 LPTLDplCLGDRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALWRMDPDMFNGSIAWHSEvglPVYA-------------- 243
Cdd:COG2319 149 LATGK--LLRTLTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTG---AVRSvafspdgkllasgs 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 61966713 244 ---HIRPRDVEA-IPRASTNPSNRKVRALAFSGKNQELGAVSLDGYFHLWKARS 293
Cdd:COG2319 224 adgTVRLWDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
95-381 9.65e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 9.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713  95 GTLNKVFASQWLNARQVVC-GTKCNTLFVVDVQSGHITRIPlmrdkeaglaQAHQGcGIHAIELNPSKTLLATGGENpNS 173
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTL----------KGHTG-PVRDVAASADGTYLASGSSD-KT 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 174 LAIYQLPTLDplCLGDRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALWRMDPDMFNGSIAWHSEVglpvyahirprdvea 252
Cdd:cd00200  75 IRLWDLETGE--CVRTLTGHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW--------------- 137
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 253 iprastnpsnrkVRALAFSGKNQELGAVSLDGYFHLWKARS-TLSRLLSIRLPYCRenvCLTYCDELSLYAVGSQSHVSF 331
Cdd:cd00200 138 ------------VNSVAFSPDGTFVASSSQDGTIKLWDLRTgKCVATLTGHTGEVN---SVAFSPDGEKLLSSSSDGTIK 202
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 61966713 332 L-DPRQRQQnirpLCSREG-GTGVRSLSFYQH--IITVGTGHGSLLFYDIRAQK 381
Cdd:cd00200 203 LwDLSTGKC----LGTLRGhENGVNSVAFSPDgyLLASGSEDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
111-290 8.78e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.57  E-value: 8.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 111 VVCGTKCNTLFVVDVQSGHITRiplmrdkeagLAQAHQGCgIHAIELNPSKTLLATGGENpNSLAIYQLPTLDplCLGDR 190
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVA----------TLTGHTGE-VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGK--CLGTL 215
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61966713 191 HGHKDWIFAVAWLSDT-VAVSGSRDGTVALWRMDPDMFNGSIAWHSEvglpvyahirprdveaiprastnpsnrKVRALA 269
Cdd:cd00200 216 RGHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTN---------------------------SVTSLA 268
                       170       180
                ....*....|....*....|.
gi 61966713 270 FSGKNQELGAVSLDGYFHLWK 290
Cdd:cd00200 269 WSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
186-220 3.53e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.53e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 61966713    186 CLGDRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALW 220
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
186-220 7.79e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 61966713   186 CLGDRHGHKDWIFAVAWLSD-TVAVSGSRDGTVALW 220
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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