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Conserved domains on  [gi|268835741|ref|NP_001013784|]
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glycine N-acyltransferase-like protein [Mus musculus]

Protein Classification

glycine N-acyltransferase family protein( domain architecture ID 10532672)

glycine N-acyltransferase family protein may transfer an acyl group to the N-terminus of glutamine; similar to mouse glycine N-acyltransferase-like protein 3 (GLYATL3) which catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, in the primary fatty acid amide biosynthetic pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-206 1.81e-130

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


:

Pssm-ID: 461802  Cd Length: 203  Bit Score: 368.83  E-value: 1.81e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741    1 MLHLRSSQMLQMLESSLRKYLPESLKVYGTVFHMNQGNPFKLKALVDKWPDFNTVVVRPREQEMGDDLDQHTNTYQIYSK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741   81 DPKHCLEFLGTPDVINWKQHLQIQSSQSNLNEAIMDLAAGKMVKVKRTQCILYMMPETAKKLVPSLLEDKEYldHQSGRP 160
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLDAKNL--SPSGKP 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 268835741  161 RAiDQEMFKLSTLDVTHAPLVDKFWQFGGNERSQRFIGRCIQIFPS 206
Cdd:pfam06021 159 KA-NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
NAT_SF super family cl17182
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ...
 207-295 1.39e-50

N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


The actual alignment was detected with superfamily member pfam08444:

Pssm-ID: 473072  Cd Length: 89  Bit Score: 161.85  E-value: 1.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741  207 SCLLGPEGTPVSWALMDQTGEIRMAGTVPDYRAQGLISHIIYAQTLAMDKRGYPVYNHTEQTNKVIQKMSHTLHHVPMPC 286
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 268835741  287 DWNQWYCAP 295
Cdd:pfam08444  81 GWNQWNCVP 89
 
Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-206 1.81e-130

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 461802  Cd Length: 203  Bit Score: 368.83  E-value: 1.81e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741    1 MLHLRSSQMLQMLESSLRKYLPESLKVYGTVFHMNQGNPFKLKALVDKWPDFNTVVVRPREQEMGDDLDQHTNTYQIYSK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741   81 DPKHCLEFLGTPDVINWKQHLQIQSSQSNLNEAIMDLAAGKMVKVKRTQCILYMMPETAKKLVPSLLEDKEYldHQSGRP 160
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLDAKNL--SPSGKP 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 268835741  161 RAiDQEMFKLSTLDVTHAPLVDKFWQFGGNERSQRFIGRCIQIFPS 206
Cdd:pfam06021 159 KA-NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
Gly_acyl_tr_C pfam08444
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the ...
 207-295 1.39e-50

Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 117021  Cd Length: 89  Bit Score: 161.85  E-value: 1.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741  207 SCLLGPEGTPVSWALMDQTGEIRMAGTVPDYRAQGLISHIIYAQTLAMDKRGYPVYNHTEQTNKVIQKMSHTLHHVPMPC 286
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 268835741  287 DWNQWYCAP 295
Cdd:pfam08444  81 GWNQWNCVP 89
 
Name Accession Description Interval E-value
Gly_acyl_tr_N pfam06021
Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian ...
 1-206 1.81e-130

Aralkyl acyl-CoA:amino acid N-acyltransferase; This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 461802  Cd Length: 203  Bit Score: 368.83  E-value: 1.81e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741    1 MLHLRSSQMLQMLESSLRKYLPESLKVYGTVFHMNQGNPFKLKALVDKWPDFNTVVVRPREQEMGDDLDQHTNTYQIYSK 80
Cdd:pfam06021   1 MLVLQCPQKLQTLEKSLRKSLPESLKVYGAVFHINRGNPFNLEVLVDSWPDFQTVITRPQKEEMTDDLDHYTNTYAIFYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741   81 DPKHCLEFLGTPDVINWKQHLQIQSSQSNLNEAIMDLAAGKMVKVKRTQCILYMMPETAKKLVPSLLEDKEYldHQSGRP 160
Cdd:pfam06021  81 DPDALQELLESPDVINWKQHFQIQGCQSSLDEVIQEVAASKSVQVKYTKYILYMTPDPAKLLTPSLLDAKNL--SPSGKP 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 268835741  161 RAiDQEMFKLSTLDVTHAPLVDKFWQFGGNERSQRFIGRCIQIFPS 206
Cdd:pfam06021 159 KA-NQEMFKLSSLDVSHAALVNETWSFGGNERSLRYIERCIQNFPS 203
Gly_acyl_tr_C pfam08444
Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the ...
 207-295 1.39e-50

Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.


Pssm-ID: 117021  Cd Length: 89  Bit Score: 161.85  E-value: 1.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268835741  207 SCLLGPEGTPVSWALMDQTGEIRMAGTVPDYRAQGLISHIIYAQTLAMDKRGYPVYNHTEQTNKVIQKMSHTLHHVPMPC 286
Cdd:pfam08444   1 FCLLGPEGTPVSWSLMDQTGELRMAGTLPKYRRQGLMSHVIYHQAQYLEKLGFPVYSHVDKANEISQKMSGNLGHVPMPC 80


                  ....*....
gi 268835741  287 DWNQWYCAP 295
Cdd:pfam08444  81 GWNQWNCVP 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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