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Conserved domains on  [gi|62471661|ref|NP_001014498|]
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Chromatin-linked adaptor for MSL proteins, isoform B [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 1.81e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 62471661   407 YLKNHARIHTGEKPYKCQTCGMQFSQ 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
359-498 1.95e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62471661 359 RNPSKPFSCNICGGLFSRYSSLWSHK--KLHSGEKNYKC----SICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQ 432
Cdd:COG5048 284 KGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKF 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62471661 433 SP-------------------------------------HLKNHERTHSGERPYVC--GVCDKGFARHATLWNHRRIHTG 473
Cdd:COG5048 364 SPllnneppqslqqykdlkndkksetlsnscirnfkrdsNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTN 443

                       170       180
                ....*....|....*....|....*
gi 62471661 474 EKPYKCEICGSaFSQAAHLKNHAKV 498
Cdd:COG5048 444 HAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
475-529 7.21e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 7.21e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62471661 475 KPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKC--EICSAAFADRFALKRHRGIHQK 529
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 1.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 62471661   407 YLKNHARIHTGEKPYKCQTCGMQFSQ 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
359-498 1.95e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62471661 359 RNPSKPFSCNICGGLFSRYSSLWSHK--KLHSGEKNYKC----SICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQ 432
Cdd:COG5048 284 KGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKF 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62471661 433 SP-------------------------------------HLKNHERTHSGERPYVC--GVCDKGFARHATLWNHRRIHTG 473
Cdd:COG5048 364 SPllnneppqslqqykdlkndkksetlsnscirnfkrdsNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTN 443

                       170       180
                ....*....|....*....|....*
gi 62471661 474 EKPYKCEICGSaFSQAAHLKNHAKV 498
Cdd:COG5048 444 HAPLLCSILKS-FRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-488 2.71e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.71e-05
                          10        20
                  ....*....|....*....|....*
gi 62471661   464 LWNHRRIHTGEKPYKCEICGSAFSQ 488
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-529 7.21e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 7.21e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62471661 475 KPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKC--EICSAAFADRFALKRHRGIHQK 529
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 1.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 62471661   407 YLKNHARIHTGEKPYKCQTCGMQFSQ 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
359-498 1.95e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62471661 359 RNPSKPFSCNICGGLFSRYSSLWSHK--KLHSGEKNYKC----SICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQ 432
Cdd:COG5048 284 KGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKF 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62471661 433 SP-------------------------------------HLKNHERTHSGERPYVC--GVCDKGFARHATLWNHRRIHTG 473
Cdd:COG5048 364 SPllnneppqslqqykdlkndkksetlsnscirnfkrdsNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTN 443

                       170       180
                ....*....|....*....|....*
gi 62471661 474 EKPYKCEICGSaFSQAAHLKNHAKV 498
Cdd:COG5048 444 HAPLLCSILKS-FRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-488 2.71e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.71e-05
                          10        20
                  ....*....|....*....|....*
gi 62471661   464 LWNHRRIHTGEKPYKCEICGSAFSQ 488
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 4.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.92e-05
                          10        20
                  ....*....|....*....|....*.
gi 62471661   435 HLKNHERTHSGERPYVCGVCDKGFAR 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 468-525 1.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62471661 468 RRIHT-GEKPYKCEI--CGSAFSQAAHLKNHAK-------------------VHSGEKPYKCEICSAAFADRFALKRHRG 525
Cdd:COG5189 340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 421-443 5.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.44e-03
                          10        20
                  ....*....|....*....|...
gi 62471661   421 YKCQTCGMQFSQSPHLKNHERTH 443
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
475-529 7.21e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 7.21e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62471661 475 KPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKC--EICSAAFADRFALKRHRGIHQK 529
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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