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Conserved domains on  [gi|62862008|ref|NP_001015151|]
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dead box protein 80, isoform B [Drosophila melanogaster]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13028937)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; such as Bacillus cereus ATP-dependent RNA helicase DbpA that is involved in the assembly of the 50S ribosomal subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 80-277 7.83e-119

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 344.94  E-value: 7.83e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  80 LKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQT 159
Cdd:cd17963   1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPPENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 160 GEVAARMGQFCrEIKLRFAVRGEEVDRSKKIEEHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIATQGHHDQCI 239
Cdd:cd17963  81 GEVVEKMGKFT-GVKVALAVPGNDVPRGKKITAQIVIGTPGTVLDW-LKKRQLDLKKIKILVLDEADVMLDTQGHGDQSI 158

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 62862008 240 RIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd17963 159 RIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 288-417 5.95e-47

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 158.05  E-value: 5.95e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 288 IKQYYVKCKNEEGKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKV 367
Cdd:cd18787   1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62862008 368 LITTNILSRGIDIEQVTIVVNFDLPvdldgmADCETYLHRIGRTGRFGKK 417
Cdd:cd18787  81 LVATDVAARGLDIPGVDHVINYDLP------RDAEDYVHRIGRTGRAGRK 124
 
Name Accession Description Interval E-value
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 80-277 7.83e-119

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 344.94  E-value: 7.83e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  80 LKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQT 159
Cdd:cd17963   1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPPENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 160 GEVAARMGQFCrEIKLRFAVRGEEVDRSKKIEEHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIATQGHHDQCI 239
Cdd:cd17963  81 GEVVEKMGKFT-GVKVALAVPGNDVPRGKKITAQIVIGTPGTVLDW-LKKRQLDLKKIKILVLDEADVMLDTQGHGDQSI 158

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 62862008 240 RIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd17963 159 RIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
74-417 6.98e-108

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 325.56  E-value: 6.98e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  74 TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNV-CLNHPQVLCLSPT 152
Cdd:COG0513   3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAG--RDVLGQAQTGTGKTAAFLLPLLQRLDPsRPRAPQALILAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 153 YELAIQTGEVAARMGQFCReIKLRFAVRGeeVDRSKKIEE-----HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADV 227
Cdd:COG0513  81 RELALQVAEELRKLAKYLG-LRVATVYGG--VSIGRQIRAlkrgvDIVVATPGRLLDL-IERGALDLSGVETLVLDEADR 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 228 MIAtQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEgKYNAIQN 307
Cdd:COG0513 157 MLD-MGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD-KLELLRR 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 308 IYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVV 387
Cdd:COG0513 235 LLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVI 314

                       330       340       350
                ....*....|....*....|....*....|
gi 62862008 388 NFDLPvdldgmADCETYLHRIGRTGRFGKK 417
Cdd:COG0513 315 NYDLP------EDPEDYVHRIGRTGRAGAE 338
PTZ00424 PTZ00424
helicase 45; Provisional
 72-417 1.43e-86

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 270.16  E-value: 1.43e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   72 VKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSP 151
Cdd:PTZ00424  27 VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDG--YDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  152 TYELAIQTGEVAARMGQFCrEIKLRFAVRGEEV-DRSKKIEE--HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVM 228
Cdd:PTZ00424 105 TRELAQQIQKVVLALGDYL-KVRCHACVGGTVVrDDINKLKAgvHMVVGTPGRVYDM-IDKRHLRVDDLKLFILDEADEM 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  229 IaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEGKYNAIQNI 308
Cdd:PTZ00424 183 L-SRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFDTLCDL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  309 YGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVN 388
Cdd:PTZ00424 262 YETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVIN 341

                        330       340
                 ....*....|....*....|....*....
gi 62862008  389 FDLPVDLdgmadcETYLHRIGRTGRFGKK 417
Cdd:PTZ00424 342 YDLPASP------ENYIHRIGRSGRFGRK 364
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 288-417 5.95e-47

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 158.05  E-value: 5.95e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 288 IKQYYVKCKNEEGKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKV 367
Cdd:cd18787   1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62862008 368 LITTNILSRGIDIEQVTIVVNFDLPvdldgmADCETYLHRIGRTGRFGKK 417
Cdd:cd18787  81 LVATDVAARGLDIPGVDHVINYDLP------RDAEDYVHRIGRTGRAGRK 124
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 97-265 1.32e-43

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 150.47  E-value: 1.32e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008    97 SKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCrEIKLR 176
Cdd:pfam00270   1 TPIQAEAIPAILEG--RDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   177 FAVRGEEV--DRSKKIEEHILIGTPGKLLDWGIKFRLFdmKKISVFVLDEADVMIaTQGHHDQCIRIHKMLNPHCQMLFF 254
Cdd:pfam00270  78 SLLGGDSRkeQLEKLKGPDILVGTPGRLLDLLQERKLL--KNLKLLVLDEAHRLL-DMGFGPDLEEILRRLPKKRQILLL 154

                         170
                  ....*....|.
gi 62862008   255 SATYGKEVMDF 265
Cdd:pfam00270 155 SATLPRNLEDL 165
DEXDc smart00487
DEAD-like helicases superfamily;
88-291 1.14e-36

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 133.39  E-value: 1.14e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008     88 IYAMGFNTPSKIQETALPTLLADPpQNMIAQSQSGTGKTAAFVLAMLSRVNvCLNHPQVLCLSPTYELAIQTGEVAARMG 167
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGL-RDVILAAPTGSGKTLAALLPALEALK-RGKGGRVLVLVPTRELAEQWAEELKKLG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008    168 QFCREIKLRF---AVRGEEVDRSKKIEEHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIAtQGHHDQCIRIHKM 244
Cdd:smart00487  79 PSLGLKVVGLyggDSKREQLRKLESGKTDILVTTPGRLLDL-LENDKLSLSNVDLVILDEAHRLLD-GGFGDQLEKLLKL 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 62862008    245 LNPHCQMLFFSATYGKEVMDFARLIVADPtiIRLMREEESLENIKQY 291
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDP--VFIDVGFTPLEPIEQF 201
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 300-415 5.76e-28

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 106.91  E-value: 5.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   300 GKYNAIQNIYGCISVGQAIIFCHTKRTAAwLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGID 379
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 62862008   380 IEQVTIVVNFDLPVDLdgmadcETYLHRIGRTGRFG 415
Cdd:pfam00271  80 LPDVDLVINYDLPWNP------ASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
329-415 6.11e-24

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 94.97  E-value: 6.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008    329 WLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLdgmadcETYLHRI 408
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSP------ASYIQRI 75


                   ....*..
gi 62862008    409 GRTGRFG 415
Cdd:smart00490  76 GRAGRAG 82
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 317-426 6.37e-09

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 58.31  E-value: 6.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 317 AIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEK--VLITTNILSRGIDIEQVTIVVNFDL--- 391
Cdd:COG0553 552 VLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEApvFLISLKAGGEGLNLTAADHVIHYDLwwn 631

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 62862008 392 PVDLDgmadcetylHRIGRTGRFG-KKTKFVFIPVT 426
Cdd:COG0553 632 PAVEE---------QAIDRAHRIGqTRDVQVYKLVA 658
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 318-415 4.39e-05

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 45.86  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  318 IIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLdg 397
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNI-- 317

                         90
                 ....*....|....*...
gi 62862008  398 madcETYLHRIGRTGRFG 415
Cdd:PRK11057 318 ----ESYYQETGRAGRDG 331
 
Name Accession Description Interval E-value
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 80-277 7.83e-119

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 344.94  E-value: 7.83e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  80 LKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQT 159
Cdd:cd17963   1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPPENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 160 GEVAARMGQFCrEIKLRFAVRGEEVDRSKKIEEHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIATQGHHDQCI 239
Cdd:cd17963  81 GEVVEKMGKFT-GVKVALAVPGNDVPRGKKITAQIVIGTPGTVLDW-LKKRQLDLKKIKILVLDEADVMLDTQGHGDQSI 158

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 62862008 240 RIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd17963 159 RIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 57-282 9.33e-114

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 333.53  E-value: 9.33e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  57 SLDIQQKNPNSPLHSVKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSR 136
Cdd:cd18048   2 RVEVLQRDPTSPLFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADPPQNLIAQSQSGTGKTAAFVLAMLSR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 137 VNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCREIKLRFAVRGEEVDRSKKIEEHILIGTPGKLLDWGIKFRLFDMKK 216
Cdd:cd18048  82 VDALKLYPQCLCLSPTFELALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKGTDIEAQIVIGTPGTVLDWCFKLRLIDVTN 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62862008 217 ISVFVLDEADVMIATQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREE 282
Cdd:cd18048 162 ISVFVLDEADVMINVQGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEE 227
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
74-417 6.98e-108

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 325.56  E-value: 6.98e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  74 TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNV-CLNHPQVLCLSPT 152
Cdd:COG0513   3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAG--RDVLGQAQTGTGKTAAFLLPLLQRLDPsRPRAPQALILAPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 153 YELAIQTGEVAARMGQFCReIKLRFAVRGeeVDRSKKIEE-----HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADV 227
Cdd:COG0513  81 RELALQVAEELRKLAKYLG-LRVATVYGG--VSIGRQIRAlkrgvDIVVATPGRLLDL-IERGALDLSGVETLVLDEADR 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 228 MIAtQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEgKYNAIQN 307
Cdd:COG0513 157 MLD-MGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD-KLELLRR 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 308 IYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVV 387
Cdd:COG0513 235 LLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVI 314

                       330       340       350
                ....*....|....*....|....*....|
gi 62862008 388 NFDLPvdldgmADCETYLHRIGRTGRFGKK 417
Cdd:COG0513 315 NYDLP------EDPEDYVHRIGRTGRAGAE 338
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 73-277 1.94e-92

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 278.14  E-value: 1.94e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  73 KTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPT 152
Cdd:cd18047   1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 153 YELAIQTGEVAARMGQFCREIKLRFAVRGEEVDRSKKIEEHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIATQ 232
Cdd:cd18047  81 YELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQ 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 62862008 233 GHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd18047 161 GHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
PTZ00424 PTZ00424
helicase 45; Provisional
 72-417 1.43e-86

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 270.16  E-value: 1.43e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   72 VKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSP 151
Cdd:PTZ00424  27 VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDG--YDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  152 TYELAIQTGEVAARMGQFCrEIKLRFAVRGEEV-DRSKKIEE--HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVM 228
Cdd:PTZ00424 105 TRELAQQIQKVVLALGDYL-KVRCHACVGGTVVrDDINKLKAgvHMVVGTPGRVYDM-IDKRHLRVDDLKLFILDEADEM 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  229 IaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEEGKYNAIQNI 308
Cdd:PTZ00424 183 L-SRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFDTLCDL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  309 YGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVN 388
Cdd:PTZ00424 262 YETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVIN 341

                        330       340
                 ....*....|....*....|....*....
gi 62862008  389 FDLPVDLdgmadcETYLHRIGRTGRFGKK 417
Cdd:PTZ00424 342 YDLPASP------ENYIHRIGRSGRFGRK 364
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 73-417 2.80e-58

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 197.47  E-value: 2.80e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   73 KTFEALHLKASLLKGIYAMGFNTPSKIQETALPtlLADPPQNMIAQSQSGTGKTAAFVLAMLSRvnvCLNHPQ------- 145
Cdd:PRK11192   1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIP--PALDGRDVLGSAPTGTGKTAAFLLPALQH---LLDFPRrksgppr 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  146 VLCLSPTYELAIQTGEVAarmGQFCREIKLRFA-------------VRGEEVDrskkieehILIGTPGKLLDWgIKFRLF 212
Cdd:PRK11192  76 ILILTPTRELAMQVADQA---RELAKHTHLDIAtitggvaymnhaeVFSENQD--------IVVATPGRLLQY-IKEENF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  213 DMKKISVFVLDEADVM-----------IATQGHHDQcirihkmlnphcQMLFFSATY-GKEVMDFARLIVADPTII---- 276
Cdd:PRK11192 144 DCRAVETLILDEADRMldmgfaqdietIAAETRWRK------------QTLLFSATLeGDAVQDFAERLLNDPVEVeaep 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  277 -RlmREEeslENIKQYYVKCKNEEGKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLD 355
Cdd:PRK11192 212 sR--RER---KKIHQWYYRADDLEHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNE 286

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62862008  356 VLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLDgmadceTYLHRIGRTGRFGKK 417
Cdd:PRK11192 287 AIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSAD------TYLHRIGRTGRAGRK 342
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 71-417 1.06e-57

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 196.56  E-value: 1.06e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   71 SVKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLS 150
Cdd:PRK11776   2 SMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAG--KDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLC 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  151 PTYELAIQTGEVAARMGQFCREIK----------------LRFAVrgeevdrskkieeHILIGTPGKLLDWGIKFRLfDM 214
Cdd:PRK11776  80 PTRELADQVAKEIRRLARFIPNIKvltlcggvpmgpqidsLEHGA-------------HIIVGTPGRILDHLRKGTL-DL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  215 KKISVFVLDEADVMIaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLmREEESLENIKQYYVK 294
Cdd:PRK11776 146 DALNTLVLDEADRML-DMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKV-ESTHDLPAIEQRFYE 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  295 CKNEEgKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNIL 374
Cdd:PRK11776 224 VSPDE-RLPALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVA 302

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 62862008  375 SRGIDIEQVTIVVNFDLPVDLdgmadcETYLHRIGRTGRFGKK 417
Cdd:PRK11776 303 ARGLDIKALEAVINYELARDP------EVHVHRIGRTGRAGSK 339
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 73-417 1.60e-54

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 187.10  E-value: 1.60e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   73 KTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRV-------NVCLNHPQ 145
Cdd:PRK04837   8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAG--RDVAGQAQTGTGKTMAFLTATFHYLlshpapeDRKVNQPR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  146 VLCLSPTYELAIQTGEVAARMGQFCReIKLRFAVRGEEVDRSKKIEEH---ILIGTPGKLLDWgIKFRLFDMKKISVFVL 222
Cdd:PRK04837  86 ALIMAPTRELAVQIHADAEPLAQATG-LKLGLAYGGDGYDKQLKVLESgvdILIGTTGRLIDY-AKQNHINLGAIQVVVL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  223 DEADVMIATQGHHDqcIR--IHKMLNPHCQM-LFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKCKNEE 299
Cdd:PRK04837 164 DEADRMFDLGFIKD--IRwlFRRMPPANQRLnMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNEE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  300 gKYNAIQNIYGCISVGQAIIFCHTKRTA----AWLAAkmtsDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILS 375
Cdd:PRK04837 242 -KMRLLQTLIEEEWPDRAIIFANTKHRCeeiwGHLAA----DGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAA 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 62862008  376 RGIDIEQVTIVVNFDLPvDldgmaDCETYLHRIGRTGRFGKK 417
Cdd:PRK04837 317 RGLHIPAVTHVFNYDLP-D-----DCEDYVHRIGRTGRAGAS 352
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 74-416 9.75e-54

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 189.67  E-value: 9.75e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   74 TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTY 153
Cdd:PRK11634   7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNG--RDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  154 ELAIQTGEVAARMGQFCREIKLRFAVRGEEVD---RSKKIEEHILIGTPGKLLDwGIKFRLFDMKKISVFVLDEADVMIa 230
Cdd:PRK11634  85 ELAVQVAEAMTDFSKHMRGVNVVALYGGQRYDvqlRALRQGPQIVVGTPGRLLD-HLKRGTLDLSKLSGLVLDEADEML- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  231 TQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYYVKC----KNEegkynAIQ 306
Cdd:PRK11634 163 RMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVwgmrKNE-----ALV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  307 NIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIV 386
Cdd:PRK11634 238 RFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLV 317

                        330       340       350
                 ....*....|....*....|....*....|
gi 62862008  387 VNFDLPVdldgmaDCETYLHRIGRTGRFGK 416
Cdd:PRK11634 318 VNYDIPM------DSESYVHRIGRTGRAGR 341
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 84-277 8.86e-53

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 175.71  E-value: 8.86e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVN----VCLNHPQVLCLSPTYELAIQT 159
Cdd:cd00268   1 LLKALKKLGFEKPTPIQAQAIPLILSG--RDVIGQAQTGSGKTLAFLLPILEKLLpepkKKGRGPQALVLAPTRELAMQI 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 160 GEVAARMGQFCReikLRFAVRGEEVDRSKKIEE-----HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIaTQGH 234
Cdd:cd00268  79 AEVARKLGKGTG---LKVAAIYGGAPIKKQIEAlkkgpDIVVGTPGRLLDL-IERGKLDLSNVKYLVLDEADRML-DMGF 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 62862008 235 HDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd00268 154 EEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 75-415 5.10e-52

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 182.03  E-value: 5.10e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   75 FEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRV-------NVCLNHPQVL 147
Cdd:PRK01297  89 FHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAG--HDAIGRAQTGTGKTAAFLISIINQLlqtpppkERYMGEPRAL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  148 CLSPTYELAIQTGEVAARMGQFCREIKLRFaVRGEEVDRSKKIEE----HILIGTPGKLLDWGIKFRL-FDMkkISVFVL 222
Cdd:PRK01297 167 IIAPTRELVVQIAKDAAALTKYTGLNVMTF-VGGMDFDKQLKQLEarfcDILVATPGRLLDFNQRGEVhLDM--VEVMVL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  223 DEADVMIaTQGHHDQCIRIHKMLNPHC--QMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQY-YVKCKNEe 299
Cdd:PRK01297 244 DEADRML-DMGFIPQVRQIIRQTPRKEerQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHvYAVAGSD- 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  300 gKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGID 379
Cdd:PRK01297 322 -KYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIH 400

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 62862008  380 IEQVTIVVNFDLPVDLDgmadceTYLHRIGRTGRFG 415
Cdd:PRK01297 401 IDGISHVINFTLPEDPD------DYVHRIGRTGRAG 430
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 74-413 2.25e-49

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 174.23  E-value: 2.25e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   74 TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQ------VL 147
Cdd:PRK10590   2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEG--RDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  148 CLSPTYELAIQTGEvaaRMGQFCREIKLRFAV--------------RGEeVDrskkieehILIGTPGKLLDWGIKfRLFD 213
Cdd:PRK10590  80 ILTPTRELAAQIGE---NVRDYSKYLNIRSLVvfggvsinpqmmklRGG-VD--------VLVATPGRLLDLEHQ-NAVK 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  214 MKKISVFVLDEADVMIATQGHHDqCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRLMREEESLENIKQYyV 293
Cdd:PRK10590 147 LDQVEILVLDEADRMLDMGFIHD-IRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQH-V 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  294 KCKNEEGKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNI 373
Cdd:PRK10590 225 HFVDKKRKRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDI 304

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 62862008  374 LSRGIDIEQVTIVVNFDLPvdldgmADCETYLHRIGRTGR 413
Cdd:PRK10590 305 AARGLDIEELPHVVNYELP------NVPEDYVHRIGRTGR 338
PTZ00110 PTZ00110
helicase; Provisional
 72-417 3.32e-49

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 175.73  E-value: 3.32e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   72 VKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNV--CLNH---PQV 146
Cdd:PTZ00110 129 VVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSG--RDMIGIAETGSGKTLAFLLPAIVHINAqpLLRYgdgPIV 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  147 LCLSPTYELAIQTGEVAArmgQFCREIKLRFAVRGEEVDRSKKIEE-----HILIGTPGKLLDWgIKFRLFDMKKISVFV 221
Cdd:PTZ00110 207 LVLAPTRELAEQIREQCN---KFGASSKIRNTVAYGGVPKRGQIYAlrrgvEILIACPGRLIDF-LESNVTNLRRVTYLV 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  222 LDEADVMIaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARlivadptiiRLMREEE------SLE-----NIKQ 290
Cdd:PTZ00110 283 LDEADRML-DMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLAR---------DLCKEEPvhvnvgSLDltachNIKQ 352

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  291 YyVKCKNEEGKYNAIQNIYGCISV--GQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVL 368
Cdd:PTZ00110 353 E-VFVVEEHEKRGKLKMLLQRIMRdgDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIM 431

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 62862008  369 ITTNILSRGIDIEQVTIVVNFDLPVDLdgmadcETYLHRIGRTGRFGKK 417
Cdd:PTZ00110 432 IATDVASRGLDVKDVKYVINFDFPNQI------EDYVHRIGRTGRAGAK 474
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 77-276 4.25e-48

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 163.65  E-value: 4.25e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  77 ALHLKASLLKGIYAMGFNTPSKIQETA-LPTLLAdppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYEL 155
Cdd:cd17939   1 DMGLSEDLLRGIYAYGFEKPSAIQQRAiVPIIKG---RDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTREL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 156 AIQTGEVAARMGQFCrEIKLRFAVRGEEVDRSKKIEE---HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIaTQ 232
Cdd:cd17939  78 AQQIQKVVKALGDYM-GVKVHACIGGTSVREDRRKLQygpHIVVGTPGRVFDM-LQRRSLRTDKIKMFVLDEADEML-SR 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 62862008 233 GHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17939 155 GFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 288-417 5.95e-47

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 158.05  E-value: 5.95e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 288 IKQYYVKCKNEEGKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKV 367
Cdd:cd18787   1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62862008 368 LITTNILSRGIDIEQVTIVVNFDLPvdldgmADCETYLHRIGRTGRFGKK 417
Cdd:cd18787  81 LVATDVAARGLDIPGVDHVINYDLP------RDAEDYVHRIGRTGRAGRK 124
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 75-279 2.17e-45

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 156.45  E-value: 2.17e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  75 FEALHLKASLLKGIYAMGFNTPSKIQETA-LPTLLAdppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTY 153
Cdd:cd18046   1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAiMPCIKG---YDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTR 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 154 ELAIQTGEVAARMGQFCrEIKLRFAVRGEEV-DRSKKIEE--HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIa 230
Cdd:cd18046  78 ELAQQIQKVVMALGDYM-GIKCHACIGGTSVrDDAQKLQAgpHIVVGTPGRVFDM-INRRYLRTDYIKMFVLDEADEML- 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 62862008 231 TQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPtiIRLM 279
Cdd:cd18046 155 SRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDP--IRIL 201
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 66-417 2.34e-45

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 165.89  E-value: 2.34e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   66 NSPLHSVkTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLadPPQNMIAQSQSGTGKTAAFVLAMLSR-------VN 138
Cdd:PRK04537   3 DKPLTDL-TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVAL--PGGDVAGQAQTGTGKTLAFLVAVMNRllsrpalAD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  139 VCLNHPQVLCLSPTYELAIQTGEVAARMGQfcrEIKLRFAVRGEEVDRSKKIE-----EHILIGTPGKLLDWGIKFRLFD 213
Cdd:PRK04537  80 RKPEDPRALILAPTRELAIQIHKDAVKFGA---DLGLRFALVYGGVDYDKQREllqqgVDVIIATPGRLIDYVKQHKVVS 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  214 MKKISVFVLDEADVMIATQGHHDqcIR-IHKMLNPHC--QMLFFSATYGKEVMDFARLIVADPTiiRLMREEESLE--NI 288
Cdd:PRK04537 157 LHACEICVLDEADRMFDLGFIKD--IRfLLRRMPERGtrQTLLFSATLSHRVLELAYEHMNEPE--KLVVETETITaaRV 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  289 KQYYVKCKNEEgkynAIQNIYGCISVGQA---IIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLE 365
Cdd:PRK04537 233 RQRIYFPADEE----KQTLLLGLLSRSEGartMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQL 308

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 62862008  366 KVLITTNILSRGIDIEQVTIVVNFDLPVdldgmaDCETYLHRIGRTGRFGKK 417
Cdd:PRK04537 309 EILVATDVAARGLHIDGVKYVYNYDLPF------DAEDYVHRIGRTARLGEE 354
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 97-265 1.32e-43

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 150.47  E-value: 1.32e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008    97 SKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVAARMGQFCrEIKLR 176
Cdd:pfam00270   1 TPIQAEAIPAILEG--RDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   177 FAVRGEEV--DRSKKIEEHILIGTPGKLLDWGIKFRLFdmKKISVFVLDEADVMIaTQGHHDQCIRIHKMLNPHCQMLFF 254
Cdd:pfam00270  78 SLLGGDSRkeQLEKLKGPDILVGTPGRLLDLLQERKLL--KNLKLLVLDEAHRLL-DMGFGPDLEEILRRLPKKRQILLL 154

                         170
                  ....*....|.
gi 62862008   255 SATYGKEVMDF 265
Cdd:pfam00270 155 SATLPRNLEDL 165
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 75-276 1.27e-39

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 141.07  E-value: 1.27e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  75 FEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYE 154
Cdd:cd18045   1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKG--RDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 155 LAIQTGEVAARMGQFCrEIKLRFAVRGEEV-DRSKKIE--EHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIaT 231
Cdd:cd18045  79 LAVQIQKVLLALGDYM-NVQCHACIGGTSVgDDIRKLDygQHIVSGTPGRVFDM-IRRRSLRTRHIKMLVLDEADEML-N 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 62862008 232 QGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd18045 156 KGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 84-277 6.08e-39

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 138.94  E-value: 6.08e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVA 163
Cdd:cd17943   1 VLEGLKAAGFQRPSPIQLAAIPLGLAG--HDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 164 ARMGQFCREIKLRFAVRGEEV--DRSKKIEEHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIATQGHHDqcIR- 240
Cdd:cd17943  79 KKIGKKLEGLKCEVFIGGTPVkeDKKKLKGCHIAVGTPGRIKQL-IELGALNVSHVRLFVLDEADKLMEGSFQKD--VNw 155

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 62862008 241 IHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 75-276 4.47e-38

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 137.04  E-value: 4.47e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  75 FEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYE 154
Cdd:cd17940   1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSG--RDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 155 LAIQTGEVAARMGQFCREIKLrfAVRGEEVDRSKKIE----EHILIGTPGKLLDWGIKfRLFDMKKISVFVLDEADVMIa 230
Cdd:cd17940  79 LALQTSQVCKELGKHMGVKVM--VTTGGTSLRDDIMRlyqtVHVLVGTPGRILDLAKK-GVADLSHCKTLVLDEADKLL- 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 62862008 231 TQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17940 155 SQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
DEXDc smart00487
DEAD-like helicases superfamily;
88-291 1.14e-36

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 133.39  E-value: 1.14e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008     88 IYAMGFNTPSKIQETALPTLLADPpQNMIAQSQSGTGKTAAFVLAMLSRVNvCLNHPQVLCLSPTYELAIQTGEVAARMG 167
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGL-RDVILAAPTGSGKTLAALLPALEALK-RGKGGRVLVLVPTRELAEQWAEELKKLG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008    168 QFCREIKLRF---AVRGEEVDRSKKIEEHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIAtQGHHDQCIRIHKM 244
Cdd:smart00487  79 PSLGLKVVGLyggDSKREQLRKLESGKTDILVTTPGRLLDL-LENDKLSLSNVDLVILDEAHRLLD-GGFGDQLEKLLKL 156

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 62862008    245 LNPHCQMLFFSATYGKEVMDFARLIVADPtiIRLMREEESLENIKQY 291
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDP--VFIDVGFTPLEPIEQF 201
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 51-423 1.76e-36

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 140.31  E-value: 1.76e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   51 LVNTKLSLDIQQKNPNSPlhsVKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFV 130
Cdd:PLN00206 102 LLRRKLEIHVKGEAVPPP---ILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSG--RSLLVSADTGSGKTASFL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  131 LAMLSRVNVCLNH-------PQVLCLSPTYELAIQTGEVAARMGQFCrEIKLRFAVRGE----EVDRSKKIEEHIlIGTP 199
Cdd:PLN00206 177 VPIISRCCTIRSGhpseqrnPLAMVLTPTRELCVQVEDQAKVLGKGL-PFKTALVVGGDampqQLYRIQQGVELI-VGTP 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  200 GKLLDWGIKFRLfDMKKISVFVLDEADVMIaTQGHHDQCIRIHKMLnPHCQMLFFSATYGKEVMDFARLIVADPTIIRLM 279
Cdd:PLN00206 255 GRLIDLLSKHDI-ELDNVSVLVLDEVDCML-ERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKFASSLAKDIILISIG 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  280 REEESLENIKQY--YVKCKNEEgkynaiQNIYGCISVGQ-----AIIFCHTKRTAAWLA-AKMTSDGHSVAVLTGDLTVV 351
Cdd:PLN00206 332 NPNRPNKAVKQLaiWVETKQKK------QKLFDILKSKQhfkppAVVFVSSRLGADLLAnAITVVTGLKALSIHGEKSMK 405

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62862008  352 QRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLdgmadcETYLHRIGRTGRFGKK-TKFVFI 423
Cdd:PLN00206 406 ERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTI------KEYIHQIGRASRMGEKgTAIVFV 472
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 74-277 1.27e-33

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 125.49  E-value: 1.27e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  74 TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLAdpPQNMIAQSQSGTGKTAAFVLAMLSRVNVclNHPQV----LCL 149
Cdd:cd17959   2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILD--GRDVVAMARTGSGKTAAFLIPMIEKLKA--HSPTVgaraLIL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 150 SPTYELAIQTGEVAARMGQFcreIKLRFA--VRGEEVDRSKKI---EEHILIGTPGKLLDWGIKFRLfDMKKISVFVLDE 224
Cdd:cd17959  78 SPTRELALQTLKVTKELGKF---TDLRTAllVGGDSLEEQFEAlasNPDIIIATPGRLLHLLVEMNL-KLSSVEYVVFDE 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 62862008 225 ADVMIAtQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd17959 154 ADRLFE-MGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 84-268 3.19e-31

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 118.51  E-value: 3.19e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVnvcLNHP------QVLCLSPTYELAI 157
Cdd:cd17947   1 LLRALSSLGFTKPTPIQAAAIPLALLG--KDICASAVTGSGKTAAFLLPILERL---LYRPkkkaatRVLVLVPTRELAM 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 158 QTGEVAARMGQFCrEIKLRFAVRGEEVdrskKIEE-------HILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIa 230
Cdd:cd17947  76 QCFSVLQQLAQFT-DITFALAVGGLSL----KAQEaalrarpDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRML- 149

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 62862008 231 TQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARL 268
Cdd:cd17947 150 EEGFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKL 187
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 80-276 1.44e-29

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 114.60  E-value: 1.44e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  80 LKASLLKGIYAMGFNTPSKIQETALPTLLAdPPQNMIAQSQSGTGKTAAFVLAMLSRVnvcLNHP--------QVLCLSP 151
Cdd:cd17964   1 LDPSLLKALTRMGFETMTPVQQKTLKPILS-TGDDVLARAKTGTGKTLAFLLPAIQSL---LNTKpagrrsgvSALIISP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 152 TYELAIQTGEVAARMGQFCREIKLRFAV----RGEEVDRSKKIEEHILIGTPGKLLD------WGIKFrlfdmKKISVFV 221
Cdd:cd17964  77 TRELALQIAAEAKKLLQGLRKLRVQSAVggtsRRAELNRLRRGRPDILVATPGRLIDhlenpgVAKAF-----TDLDYLV 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 222 LDEADVMIaTQGHHDQCIRIHKMLNP----HCQMLFFSATYGKEVMDFARLIV-ADPTII 276
Cdd:cd17964 152 LDEADRLL-DMGFRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTLkKDYKFI 210
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 74-267 9.44e-29

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 112.58  E-value: 9.44e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  74 TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRV--NVCLNH-------- 143
Cdd:cd17967   1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAG--RDLMACAQTGSGKTAAFLLPIISKLleDGPPSVgrgrrkay 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 144 PQVLCLSPTYELAIQTGEVAARmgqFCREIKLR-FAVRG--EEVDRSKKIEE--HILIGTPGKLLDWgIKFRLFDMKKIS 218
Cdd:cd17967  79 PSALILAPTRELAIQIYEEARK---FSYRSGVRsVVVYGgaDVVHQQLQLLRgcDILVATPGRLVDF-IERGRISLSSIK 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62862008 219 VFVLDEADVMIaTQGHHDQcirIHKMLNpHCQM--------LFFSATYGKEVMDFAR 267
Cdd:cd17967 155 FLVLDEADRML-DMGFEPQ---IRKIVE-HPDMppkgerqtLMFSATFPREIQRLAA 206
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 300-415 5.76e-28

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 106.91  E-value: 5.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008   300 GKYNAIQNIYGCISVGQAIIFCHTKRTAAwLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGID 379
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 62862008   380 IEQVTIVVNFDLPVDLdgmadcETYLHRIGRTGRFG 415
Cdd:pfam00271  80 LPDVDLVINYDLPWNP------ASYIQRIGRAGRAG 109
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 75-276 9.91e-28

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 109.36  E-value: 9.91e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  75 FEALHLKASLLKGIYAMGFNTPSKIQETALPTLLadppQNM--IAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPT 152
Cdd:cd17950   4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAI----LGMdvLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 153 YELAIQTGEVAARMGQFCREIKLR--FAVRGEEVDRS--KKIEEHILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVM 228
Cdd:cd17950  80 RELAFQISNEYERFSKYMPNVKTAvfFGGVPIKKDIEvlKNKCPHIVVGTPGRILAL-VREKKLKLSHVKHFVLDECDKM 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 62862008 229 IATQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17950 159 LEQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEI 206
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 84-278 1.68e-27

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 108.83  E-value: 1.68e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRV-----NVCLNH-PQVLCLSPTYELAI 157
Cdd:cd17961   5 LLKAIAKLGWEKPTLIQSKAIPLALEG--KDILARARTGSGKTAAYALPIIQKIlkakaESGEEQgTRALILVPTRELAQ 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 158 QTGEVAARMGQFCREIKLRFAVRGEEVDRSKK--IEEH--ILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIaTQG 233
Cdd:cd17961  83 QVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRalLAEKpdIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVL-SYG 161

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 62862008 234 HHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRL 278
Cdd:cd17961 162 YEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 74-273 1.97e-26

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 105.86  E-value: 1.97e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  74 TFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVnvcLNHPQ---VLCLS 150
Cdd:cd17954   1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQG--RDIIGLAETGSGKTAAFALPILQAL---LENPQrffALVLA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 151 PTYELAIQTGEVAARMGQfcrEIKLRFAVRGEEVDR-------SKKieEHILIGTPGKLLDWGIKFRLFDMKKISVFVLD 223
Cdd:cd17954  76 PTRELAQQISEQFEALGS---SIGLKSAVLVGGMDMmaqaialAKK--PHVIVATPGRLVDHLENTKGFSLKSLKFLVMD 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 62862008 224 EADVMIATqghhDQCIRIHKMLN--PHC-QMLFFSATYGKEVMDFARLIVADP 273
Cdd:cd17954 151 EADRLLNM----DFEPEIDKILKviPRErTTYLFSATMTTKVAKLQRASLKNP 199
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 84-276 9.35e-25

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 100.91  E-value: 9.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNV--CLNH---PQVLCLSPTYELAIQ 158
Cdd:cd17966   1 VMDELKRQGFTEPTAIQAQGWPMALSG--RDMVGIAQTGSGKTLAFLLPAIVHINAqpPLERgdgPIVLVLAPTRELAQQ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 159 TGEVAARmgqFCREIKLRFAVRGEEVDRSKKIEE-----HILIGTPGKLLDwgikfrLFD-----MKKISVFVLDEADVM 228
Cdd:cd17966  79 IQQEANK---FGGSSRLRNTCVYGGAPKGPQIRDlrrgvEICIATPGRLID------FLDqgktnLRRVTYLVLDEADRM 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 62862008 229 IaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17966 150 L-DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 75-273 1.00e-24

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 101.15  E-value: 1.00e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  75 FEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYE 154
Cdd:cd17955   1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAG--RDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 155 LAIQTGEVAARMGQFcreIKLRFAVRGEEVDRSKKIEE-----HILIGTPGKLLD------WGIKfrlfDMKKISVFVLD 223
Cdd:cd17955  79 LAYQIAEQFRALGAP---LGLRCCVIVGGMDMVKQALElskrpHIVVATPGRLADhlrssdDTTK----VLSRVKFLVLD 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 62862008 224 EADVMIaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADP 273
Cdd:cd17955 152 EADRLL-TGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKP 200
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 63-267 1.67e-24

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 101.97  E-value: 1.67e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  63 KNPNSPlhsVKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVnvcLN 142
Cdd:cd18052  36 RNPPPA---ILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAG--RDLMACAQTGSGKTAAFLLPVLTGM---MK 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 143 H------------PQVLCLSPTYELAIQTGEvAARMgqFCREIKLRFAV--RGEEVDRS-KKIEE--HILIGTPGKLLDW 205
Cdd:cd18052 108 EgltassfsevqePQALIVAPTRELANQIFL-EARK--FSYGTCIRPVVvyGGVSVGHQiRQIEKgcHILVATPGRLLDF 184

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 206 gIKFRLFDMKKISVFVLDEADVMIaTQGHHDQcirIHKMLNpHCQM--------LFFSATYGKEVMDFAR 267
Cdd:cd18052 185 -IGRGKISLSKLKYLILDEADRML-DMGFGPE---IRKLVS-EPGMpskedrqtLMFSATFPEEIQRLAA 248
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 84-276 2.56e-24

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 99.80  E-value: 2.56e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVnvcLNHPQV--------LCLSPTYEL 155
Cdd:cd17952   1 LLNAIRKQEYEQPTPIQAQALPVALSG--RDMIGIAKTGSGKTAAFIWPMLVHI---MDQRELekgegpiaVIVAPTREL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 156 AIQtgeVAARMGQFCREIKLR-FAVRGEEV--DRSKKIEE--HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIa 230
Cdd:cd17952  76 AQQ---IYLEAKKFGKAYNLRvVAVYGGGSkwEQAKALQEgaEIVVATPGRLIDM-VKKKATNLQRVTYLVLDEADRMF- 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 62862008 231 TQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17952 151 DMGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
HELICc smart00490
helicase superfamily c-terminal domain;
329-415 6.11e-24

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 94.97  E-value: 6.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008    329 WLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLdgmadcETYLHRI 408
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSP------ASYIQRI 75


                   ....*..
gi 62862008    409 GRTGRFG 415
Cdd:smart00490  76 GRAGRAG 82
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 75-274 2.02e-23

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 97.39  E-value: 2.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  75 FEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVnvclnhpQVLCLSPTYE 154
Cdd:cd17938   1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGG--GDVLMAAETGSGKTGAFCLPVLQIV-------VALILEPSRE 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 155 LAIQTGEVAARMGQFCREIKLRFA--VRGEEV-DRSKKIEE--HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMI 229
Cdd:cd17938  72 LAEQTYNCIENFKKYLDNPKLRVAllIGGVKArEQLKRLESgvDIVVGTPGRLEDL-IKTGKLDLSSVRFFVLDEADRLL 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 62862008 230 aTQGHHDQCIRIHKMLNPHC------QMLFFSAT-YGKEVMDFARLIVADPT 274
Cdd:cd17938 151 -SQGNLETINRIYNRIPKITsdgkrlQVIVCSATlHSFEVKKLADKIMHFPT 201
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 84-279 2.08e-23

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 97.27  E-value: 2.08e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADPpqNMIAQSQSGTGKTAAFVLAMLSRVNVCLN--HPQVLCLSPTYELAIQTGE 161
Cdd:cd17957   1 LLNNLEESGYREPTPIQMQAIPILLHGR--DLLACAPTGSGKTLAFLIPILQKLGKPRKkkGLRALILAPTRELASQIYR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 162 VAARmgqFCREIKLRFAV-RGEEVDRSKKIEEH-----ILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIATqGHH 235
Cdd:cd17957  79 ELLK---LSKGTGLRIVLlSKSLEAKAKDGPKSitkydILVSTPLRLVFL-LKQGPIDLSSVEYLVLDEADKLFEP-GFR 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 62862008 236 DQCIRIHKML-NPHCQMLFFSATYGKEVMDFARLIVADPtiIRLM 279
Cdd:cd17957 154 EQTDEILAACtNPNLQRSLFSATIPSEVEELARSVMKDP--IRII 196
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 84-267 1.13e-22

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 95.34  E-value: 1.13e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRV-----NVCLNHPQVLCLSPTYELAIQ 158
Cdd:cd17960   1 ILDVVAELGFTSMTPVQAATIPLFLSN--KDVVVEAVTGSGKTLAFLIPVLEILlkrkaNLKKGQVGALIISPTRELATQ 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 159 TGEVAARMGQF-CREIKLRFAVRGEEVDR-SKKIEEH---ILIGTPGKLLD-WGIKFRLFDMKKISVFVLDEADVMIATq 232
Cdd:cd17960  79 IYEVLQSFLEHhLPKLKCQLLIGGTNVEEdVKKFKRNgpnILVGTPGRLEElLSRKADKVKVKSLEVLVLDEADRLLDL- 157

                       170       180       190
                ....*....|....*....|....*....|....*
gi 62862008 233 GHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFAR 267
Cdd:cd17960 158 GFEADLNRILSKLPKQRRTGLFSATQTDAVEELIK 192
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 84-276 1.34e-22

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 94.92  E-value: 1.34e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNHPQVLCLSPTYELAIQTGEVA 163
Cdd:cd17962   1 LSSNLKKAGYEVPTPIQMQMIPVGLLG--RDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 164 ARMGQFCREIKLRFAVRGEEVD-RSKKIEEHI--LIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIaTQGHHDQCIR 240
Cdd:cd17962  79 KELMKGLPPMKTALLVGGLPLPpQLYRLQQGVkvIIATPGRLLDI-LKQSSVELDNIKIVVVDEADTML-KMGFQQQVLD 156

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 62862008 241 IHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17962 157 ILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 85-276 5.12e-22

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 93.12  E-value: 5.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  85 LKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSrvnvCLNHPQ--------VLCLSPTYELA 156
Cdd:cd17941   2 LKGLKEAGFIKMTEIQRDSIPHALQG--RDILGAAKTGSGKTLAFLVPLLE----KLYRERwtpedglgALIISPTRELA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 157 IQTGEVAARMGQF----------CREIKlrfavrgEEVDRSKKIeeHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEAD 226
Cdd:cd17941  76 MQIFEVLRKVGKYhsfsagliigGKDVK-------EEKERINRM--NILVCTPGRLLQHMDETPGFDTSNLQMLVLDEAD 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 62862008 227 vMIATQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17941 147 -RILDMGFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 84-229 2.87e-21

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 91.61  E-value: 2.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLAdpPQNMIAQSQSGTGKTAAFVLAMLSRVN--------VCLNHPQVLCLSPTYEL 155
Cdd:cd17945   1 LLRVIRKLGYKEPTPIQRQAIPIGLQ--NRDIIGIAETGSGKTAAFLIPLLVYISrlppldeeTKDDGPYALILAPTREL 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62862008 156 AIQTGEVAARMGQF--CREIKLrfaVRGE-EVDRSKKIEE--HILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMI 229
Cdd:cd17945  79 AQQIEEETQKFAKPlgIRVVSI---VGGHsIEEQAFSLRNgcEILIATPGRLLDC-LERRLLVLNQCTYVVLDEADRMI 153
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 57-272 6.16e-21

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 91.22  E-value: 6.16e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  57 SLDIQQKNPNSPLHSVKTFEAlHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSR 136
Cdd:cd18049   9 SKEITVRGHNCPKPVLNFYEA-NFPANVMDVIARQNFTEPTAIQAQGWPVALSG--LDMVGVAQTGSGKTLSYLLPAIVH 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 137 VN--VCLNH---PQVLCLSPTYELAIQTGEVAARMGQFCReikLRF------AVRGEEV-DRSKKIEehILIGTPGKLLD 204
Cdd:cd18049  86 INhqPFLERgdgPICLVLAPTRELAQQVQQVAAEYGRACR---LKStciyggAPKGPQIrDLERGVE--ICIATPGRLID 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62862008 205 WgIKFRLFDMKKISVFVLDEADVMIaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVAD 272
Cdd:cd18049 161 F-LEAGKTNLRRCTYLVLDEADRML-DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKD 226
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 72-276 8.93e-20

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 87.43  E-value: 8.93e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  72 VKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVnvcLNHPQV----- 146
Cdd:cd17953  11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSG--RDVIGIAKTGSGKTLAFLLPMFRHI---KDQRPVkpgeg 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 147 ---LCLSPTYELAIQtgeVAARMGQFCREIKLRFA--VRGEEVdrSKKIEE-----HILIGTPGKLLDW-----GikfRL 211
Cdd:cd17953  86 pigLIMAPTRELALQ---IYVECKKFSKALGLRVVcvYGGSGI--SEQIAElkrgaEIVVCTPGRMIDIltannG---RV 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62862008 212 FDMKKISVFVLDEADVMIaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17953 158 TNLRRVTYVVLDEADRMF-DMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 84-276 2.59e-19

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 85.85  E-value: 2.59e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSrvnVCLNH-----------PQVLCLSPT 152
Cdd:cd17951   1 ILKGLKKKGIKKPTPIQMQGLPTILSG--RDMIGIAFTGSGKTLVFTLPLIM---FALEQekklpfikgegPYGLIVCPS 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 153 YELAIQTGEVAARMGQFCRE-----IKLRFAVRGEEV-DRSKKIEE--HILIGTPGKLLDwgikfrLFDMKKISV----- 219
Cdd:cd17951  76 RELARQTHEVIEYYCKALQEggypqLRCLLCIGGMSVkEQLEVIRKgvHIVVATPGRLMD------MLNKKKINLdicry 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62862008 220 FVLDEADVMIaTQGHHDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17951 150 LCLDEADRMI-DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 91-277 5.14e-19

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 85.33  E-value: 5.14e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  91 MGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNH------PQVLCLSPTYELAIQTGEVAA 164
Cdd:cd17949   9 MGIEKPTAIQKLAIPVLLQG--RDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRvdrsdgTLALVLVPTRELALQIYEVLE 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 165 RMGQFCREIKLRFAVRGEevdrSKKIEE-------HILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVM--------I 229
Cdd:cd17949  87 KLLKPFHWIVPGYLIGGE----KRKSEKarlrkgvNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLldmgfekdI 162

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 62862008 230 AT--QGHHDQCIRIHKMLN--PHCQMLFFSATYGKEVMDFARLIVADPTIIR 277
Cdd:cd17949 163 TKilELLDDKRSKAGGEKSkpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 85-268 1.00e-18

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 83.95  E-value: 1.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  85 LKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFV---LAMLSRVNVC-LNHPQVLCLSPTYELAIQTG 160
Cdd:cd17942   2 LKAIEEMGFTKMTEIQAKSIPPLLEG--RDVLGAAKTGSGKTLAFLipaIELLYKLKFKpRNGTGVIIISPTRELALQIY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 161 EVAARMGQFCRE---IKLRFAVRGEEVDRSKKiEEHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADvMIATQGHHDQ 237
Cdd:cd17942  80 GVAKELLKYHSQtfgIVIGGANRKAEAEKLGK-GVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEAD-RILEIGFEEE 157

                       170       180       190
                ....*....|....*....|....*....|.
gi 62862008 238 CIRIHKMLNPHCQMLFFSATYGKEVMDFARL 268
Cdd:cd17942 158 MRQIIKLLPKRRQTMLFSATQTRKVEDLARI 188
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 84-276 2.80e-18

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 82.51  E-value: 2.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRVNVCL------NHPQVLCLSPTYELAI 157
Cdd:cd17958   1 IMKEIKKQGFEKPSPIQSQAWPIILQG--IDLIGVAQTGTGKTLAYLLPGFIHLDLQPipreqrNGPGVLVLTPTRELAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 158 QT-GEVAARMGQFCREIKLRFA-VRGEEV-DRSKKIEehILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIaTQGH 234
Cdd:cd17958  79 QIeAECSKYSYKGLKSVCVYGGgNRNEQIeDLSKGVD--IIIATPGRLNDL-QMNNVINLKSITYLVLDEADRML-DMGF 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 62862008 235 HDQCIRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTII 276
Cdd:cd17958 155 EPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 65-267 6.82e-18

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 82.78  E-value: 6.82e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  65 PNSPLHsVKTFEALHLKASLLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRV------- 137
Cdd:cd18051  14 ENCPPH-IETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSK--RDLMACAQTGSGKTAAFLLPILSQIyeqgpge 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 138 ---------NVCLNHPQVLCLSPTYELAIQTGEVAarmgqfcREIKLRFAVR------GEEV-DRSKKIEE--HILIGTP 199
Cdd:cd18051  91 slpsesgyyGRRKQYPLALVLAPTRELASQIYDEA-------RKFAYRSRVRpcvvygGADIgQQMRDLERgcHLLVATP 163

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62862008 200 GKLLDwgikfrLFDMKKISV-----FVLDEADVMIaTQGHHDQCIRIHKMLN-PHC---QMLFFSATYGKEVMDFAR 267
Cdd:cd18051 164 GRLVD------MLERGKIGLdyckyLVLDEADRML-DMGFEPQIRRIVEQDTmPPTgerQTLMFSATFPKEIQMLAR 233
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 93-278 3.65e-17

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 81.21  E-value: 3.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  93 FNTPSKIQETALPtlLADPPQNMIAQSQSGTGKTAAFVLAMLsrvnVCLNH---------PQVLCLSPTYELAIQTGEVA 163
Cdd:cd18050  82 FKEPTPIQCQGFP--LALSGRDMVGIAQTGSGKTLAYLLPAI----VHINHqpylergdgPICLVLAPTRELAQQVQQVA 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 164 ARMGQfCREIKLRF----AVRGEEV-DRSKKIEehILIGTPGKLLDWgIKFRLFDMKKISVFVLDEADVMIaTQGHHDQC 238
Cdd:cd18050 156 DDYGK-SSRLKSTCiyggAPKGPQIrDLERGVE--ICIATPGRLIDF-LEAGKTNLRRCTYLVLDEADRML-DMGFEPQI 230

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 62862008 239 IRIHKMLNPHCQMLFFSATYGKEVMDFARLIVADPTIIRL 278
Cdd:cd18050 231 RKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 84-257 2.88e-16

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 77.66  E-value: 2.88e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADpPQNMIAQSQSGTGKTAAFVLAMLSRvnvCLN------------HPQVLCLSP 151
Cdd:cd17946   1 ILRALADLGFSEPTPIQALALPAAIRD-GKDVIGAAETGSGKTLAFGIPILER---LLSqkssngvggkqkPLRALILTP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 152 TYELAIQtgeVAARMGQFCR--EIKLRFAVRGEEVDRSKKI---EEHILIGTPGKLLDW---GIKFrLFDMKKISVFVLD 223
Cdd:cd17946  77 TRELAVQ---VKDHLKAIAKytNIKIASIVGGLAVQKQERLlkkRPEIVVATPGRLWELiqeGNEH-LANLKSLRFLVLD 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 62862008 224 EADVMIaTQGHHDQCIRIHKMLNPHC-------QMLFFSAT 257
Cdd:cd17946 153 EADRML-EKGHFAELEKILELLNKDRagkkrkrQTFVFSAT 192
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
122-387 7.52e-16

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 79.68  E-value: 7.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 122 GTGKT--AAFVLAMLSRVNVclnhpqVLCLSPTYELAIQTGEVAARmgqfcreiklrFAVRGEEVDRSKKIEEHILIGTP 199
Cdd:COG1061 110 GTGKTvlALALAAELLRGKR------VLVLVPRRELLEQWAEELRR-----------FLGDPLAGGGKKDSDAPITVATY 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 200 GKLLdWGIKFRLFDmKKISVFVLDEAdvmiatqgHH---DQCIRIHKMLNPHCqMLFFSATY----GKEV---------- 262
Cdd:COG1061 173 QSLA-RRAHLDELG-DRFGLVIIDEA--------HHagaPSYRRILEAFPAAY-RLGLTATPfrsdGREIllflfdgivy 241

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 263 -MDFARLI----VADPTII--------RLMREEESLENIKQYYVKckNEEGKYNAIQNIY-GCISVGQAIIFCHTKRTAA 328
Cdd:COG1061 242 eYSLKEAIedgyLAPPEYYgirvdltdERAEYDALSERLREALAA--DAERKDKILRELLrEHPDDRKTLVFCSSVDHAE 319

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62862008 329 WLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVV 387
Cdd:COG1061 320 ALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI 378
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 114-257 3.82e-14

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 69.35  E-value: 3.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 114 NMIAQSQSGTGKTAAFVLAMLSRVNvcLNHPQVLCLSPTYELAIQTgevAARMGQFCRE-IKLRFAVRG---EEVDRSKK 189
Cdd:cd00046   3 NVLITAPTGSGKTLAALLAALLLLL--KKGKKVLVLVPTKALALQT---AERLRELFGPgIRVAVLVGGssaEEREKNKL 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62862008 190 IEEHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVM-IATQGHHDQCIRIHKMLNPHCQMLFFSAT 257
Cdd:cd00046  78 GDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALlIDSRGALILDLAVRKAGLKNAQVILLSAT 146
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 84-228 3.98e-13

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 68.55  E-value: 3.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLADppQNMIAQSQSGTGKTAAFVLAMLSRV-------NVCLNHPQVLCLSPTYELA 156
Cdd:cd17948   1 LVEILQRQGITKPTTVQKQGIPSILRG--RNTLCAAETGSGKTLTYLLPIIQRLlrykllaEGPFNAPRGLVITPSRELA 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62862008 157 IQTGEVAArmgQFCREIKLRfaVRGEEVDRSKKI-------EEHILIGTPGKLLDwGIKFRLFDMKKISVFVLDEADVM 228
Cdd:cd17948  79 EQIGSVAQ---SLTEGLGLK--VKVITGGRTKRQirnphfeEVDILVATPGALSK-LLTSRIYSLEQLRHLVLDEADTL 151
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 84-257 1.15e-11

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 64.19  E-value: 1.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  84 LLKGIYAMGFNTPSKIQETALPTLLAD-------PPQNMIAQSQSGTGKTAAFVL----AMLSRVnvclnHPQVLCL--S 150
Cdd:cd17956   1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyRPGDLCVSAPTGSGKTLAYVLpivqALSKRV-----VPRLRALivV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 151 PTYELAIQtgeVAARMGQFCREIKLRFAVRGEEVDRSKKIEEH-------------ILIGTPGKLLDWGIKFRLFDMKKI 217
Cdd:cd17956  76 PTKELVQQ---VYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLlvdtsgrylsrvdILVATPGRLVDHLNSTPGFTLKHL 152

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62862008 218 SVFVLDEAD-------------VMIATQGHHDQCIRIHKMLN------PHCQMLFFSAT 257
Cdd:cd17956 153 RFLVIDEADrllnqsfqdwletVMKALGRPTAPDLGSFGDANllersvRPLQKLLFSAT 211
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 113-267 2.86e-11

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 62.56  E-value: 2.86e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 113 QNMIAQSQSGTGKTAAFVLAMLSRVNVCLNH------PQVLCLSPTYELAIQtgeVAARMGQFCREIKLRFAVRG----E 182
Cdd:cd17944  28 KDLIAQARTGTGKTFSFAIPLIEKLQEDQQPrkrgraPKVLVLAPTRELANQ---VTKDFKDITRKLSVACFYGGtpyqQ 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 183 EVDRSKK-IEehILIGTPGKLLDWGIKFRLfDMKKISVFVLDEADVMIaTQGHHDQCIRIHKML-------NPhcQMLFF 254
Cdd:cd17944 105 QIFAIRNgID--ILVGTPGRIKDHLQNGRL-DLTKLKHVVLDEVDQML-DMGFAEQVEEILSVSykkdsedNP--QTLLF 178

                       170
                ....*....|...
gi 62862008 255 SATYGKEVMDFAR 267
Cdd:cd17944 179 SATCPDWVYNVAK 191
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 317-426 6.37e-09

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 58.31  E-value: 6.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 317 AIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEK--VLITTNILSRGIDIEQVTIVVNFDL--- 391
Cdd:COG0553 552 VLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEApvFLISLKAGGEGLNLTAADHVIHYDLwwn 631

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 62862008 392 PVDLDgmadcetylHRIGRTGRFG-KKTKFVFIPVT 426
Cdd:COG0553 632 PAVEE---------QAIDRAHRIGqTRDVQVYKLVA 658
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 296-409 7.17e-09

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 54.02  E-value: 7.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 296 KNEE---GKYNA-IQNIYGCISVGQ-AIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEK--VL 368
Cdd:cd18793   4 KIEEvvsGKLEAlLELLEELREPGEkVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvFL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 62862008 369 ITTNILSRGIDIEQVTIVVNFDLP----VDLDGMADCetylHRIG 409
Cdd:cd18793  84 LSTKAGGVGLNLTAANRVILYDPWwnpaVEEQAIDRA----HRIG 124
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
216-413 1.68e-08

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 56.69  E-value: 1.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 216 KISVFVLDEAdvmiatqghHdqCI------------RIHKMLN--PHCQMLFFSATYGKEVMD--FARLIVADPTIIR-- 277
Cdd:COG0514 131 KISLFAIDEA---------H--CIsqwghdfrpdyrRLGELRErlPNVPVLALTATATPRVRAdiAEQLGLEDPRVFVgs 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 278 LMREeesleNIkQYYVKCKNEEGKYNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVL 357
Cdd:COG0514 200 FDRP-----NL-RLEVVPKPPDDKLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQ 273

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62862008 358 DRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLdgmadcETYLHRIGRTGR 413
Cdd:COG0514 274 DRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSI------EAYYQEIGRAGR 323
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
100-418 1.89e-08

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 56.44  E-value: 1.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 100 QETALPTLLADPpQNMIAQSQSGTGKTAAFVLAMLSRVNvclNHPQVLCLSPTYELAiqtGEVAARMGQFCREIKLRFAV 179
Cdd:COG1204  27 QAEALEAGLLEG-KNLVVSAPTASGKTLIAELAILKALL---NGGKALYIVPLRALA---SEKYREFKRDFEELGIKVGV 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 180 R-GE-EVDRSKKIEEHILIGTPGKLlDWGIKFRLFDMKKISVFVLDEA------------DVMIAtqghhdqciRIhKML 245
Cdd:COG1204 100 StGDyDSDDEWLGRYDILVATPEKL-DSLLRNGPSWLRDVDLVVVDEAhliddesrgptlEVLLA---------RL-RRL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 246 NPHCQMLFFSATYGkEVMDFARLIVADPTI-----IRLMREEESLENIkqyYVKCKNEEGKYNAIQNIYGCISV-GQAII 319
Cdd:COG1204 169 NPEAQIVALSATIG-NAEEIAEWLDAELVKsdwrpVPLNEGVLYDGVL---RFDDGSRRSKDPTLALALDLLEEgGQVLV 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 320 FCHTKRtAAWLAAKMTSD--------------------------------------GHSVAVLTGDLTVVQRLDVLDRFR 361
Cdd:COG1204 245 FVSSRR-DAESLAKKLADelkrrltpeereeleelaeellevseethtnekladclEKGVAFHHAGLPSELRRLVEDAFR 323

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62862008 362 SGLEKVLITTNILSRGidieqvtivVNfdLPVD--------LDGMADCET--YLHRIGRTGRFGKKT 418
Cdd:COG1204 324 EGLIKVLVATPTLAAG---------VN--LPARrviirdtkRGGMVPIPVleFKQMAGRAGRPGYDP 379
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 315-416 2.86e-08

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 52.21  E-value: 2.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 315 GQAIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVD 394
Cdd:cd18794  31 GSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKS 110

                        90       100
                ....*....|....*....|..
gi 62862008 395 LdgmadcETYLHRIGRTGRFGK 416
Cdd:cd18794 111 M------ESYYQESGRAGRDGL 126
SF2_C_dicer cd18802
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ...
 316-392 3.76e-08

C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350189 [Multi-domain]  Cd Length: 142  Bit Score: 52.21  E-value: 3.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 316 QAIIFCHTKRTAAWLAAKM-----TSDGHSVAVLTG----------DLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDI 380
Cdd:cd18802  27 RGIIFVERRATAVVLSRLLkehpsTLAFIRCGFLIGrgnssqrkrsLMTQRKQKETLDKFRDGELNLLIATSVLEEGIDV 106

                        90
                ....*....|..
gi 62862008 381 EQVTIVVNFDLP 392
Cdd:cd18802 107 PACNLVIRFDLP 118
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 75-261 1.62e-07

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 52.38  E-value: 1.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  75 FEALHL----KASLLKGIYAMGFNT-----PSKIQETALPTLLADPPQN---------------MIAqSQSGTGKTAAFV 130
Cdd:cd17965   1 FDQLKLlpsvREAIIKEILKGSNKTdeeikPSPIQTLAIKKLLKTLMRKvtkqtsneepklevfLLA-AETGSGKTLAYL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 131 LAMLS---------------RVNVCLNH--PQVLCLSPTYELAIQTGEVAARMGQFC----REIKLRFAVRGEEVDRSKK 189
Cdd:cd17965  80 APLLDylkrqeqepfeeaeeEYESAKDTgrPRSVILVPTHELVEQVYSVLKKLSHTVklgiKTFSSGFGPSYQRLQLAFK 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62862008 190 IEEHILIGTPGKLLdwGI-KFRLFDMKKISVFVLDEADVMIATQGHHDQCIRIHKMLNPHCqMLFFSATYGKE 261
Cdd:cd17965 160 GRIDILVTTPGKLA--SLaKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKH-LILCSATIPKE 229
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
266-423 2.52e-07

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 53.20  E-value: 2.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 266 ARLIVADPTIIRLMREEESL--ENIKQYYVKckneegkyNAIQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSVAV 343
Cdd:COG1111 311 SKRLVSDPRFRKAMRLAEEAdiEHPKLSKLR--------EILKEQLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGR 382

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 344 LTGD--------LTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDlPVdldgmadcET---YLHRIGRTG 412
Cdd:COG1111 383 FVGQaskegdkgLTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYE-PV--------PSeirSIQRKGRTG 453

                       170
                ....*....|.
gi 62862008 413 RFGKKTKFVFI 423
Cdd:COG1111 454 RKREGRVVVLI 464
DEXHc_RecG cd17918
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ...
 95-257 4.03e-06

DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350676 [Multi-domain]  Cd Length: 180  Bit Score: 47.03  E-value: 4.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  95 TPSKIQETALPTLLAD----PPQNMIAQSQSGTGKTAAFVLAMLSRVNvclNHPQVLCLSPTYELAIQTGEVAARmgqFC 170
Cdd:cd17918  15 SLTKDQAQAIKDIEKDlhspEPMDRLLSGDVGSGKTLVALGAALLAYK---NGKQVAILVPTEILAHQHYEEARK---FL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 171 REIKLRFAVRGeevdRSKKIEEHI--LIGTpGKLLDWGIKFrlfdmKKISVFVLDEADVMIATQGHhdqciRIHKMLNPH 248
Cdd:cd17918  89 PFINVELVTGG----TKAQILSGIslLVGT-HALLHLDVKF-----KNLDLVIVDEQHRFGVAQRE-----ALYNLGATH 153


                ....*....
gi 62862008 249 cqMLFFSAT 257
Cdd:cd17918 154 --FLEATAT 160
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
 318-424 1.78e-05

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 44.56  E-value: 1.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 318 IIFCHTKRTAAWLAAKM------TSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDL 391
Cdd:cd18796  42 LVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGS 121

                        90       100       110
                ....*....|....*....|....*....|....
gi 62862008 392 PvdldgmADCETYLHRIGRTG-RFGKKTKFVFIP 424
Cdd:cd18796 122 P------KSVARLLQRLGRSGhRPGAASKGRLVP 149
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 366-417 1.87e-05

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 42.69  E-value: 1.87e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 62862008 366 KVLITTNILSRGIDIEQVTIVVNFDLPVDLdgmadcETYLHRIGRTGRFGKK 417
Cdd:cd18785  24 EILVATNVLGEGIDVPSLDTVIFFDPPSSA------ASYIQRVGRAGRGGKD 69
SF2_C_Hrq cd18797
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ...
 316-424 3.91e-05

C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350184 [Multi-domain]  Cd Length: 146  Bit Score: 43.40  E-value: 3.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 316 QAIIFCHTKRTA----AWLAAKMTSDGH---SVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVN 388
Cdd:cd18797  37 KTIVFCRSRKLAelllRYLKARLVEEGPlasKVASYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVL 116

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 62862008 389 FDLPvdlDGMAdceTYLHRIGRTGRFGKKTKFVFIP 424
Cdd:cd18797 117 AGYP---GSLA---SLWQQAGRAGRRGKDSLVILVA 146
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 318-415 4.39e-05

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 45.86  E-value: 4.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  318 IIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDLPVDLdg 397
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNI-- 317

                         90
                 ....*....|....*...
gi 62862008  398 madcETYLHRIGRTGRFG 415
Cdd:PRK11057 318 ----ESYYQETGRAGRDG 331
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
 338-413 8.45e-05

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 42.34  E-value: 8.45e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62862008 338 GHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDL---PVDLdgmadcetyLHRIGRTGR 413
Cdd:cd18801  64 GQASGKSSKGMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDAspsPIRM---------IQRMGRTGR 133
SF2_C_UvrB cd18790
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ...
 323-413 1.42e-04

C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350177 [Multi-domain]  Cd Length: 171  Bit Score: 42.23  E-value: 1.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 323 TKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVNFDlpVDLDGMADCE 402
Cdd:cd18790  36 TKRMAEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILD--ADKEGFLRSE 113

                        90
                ....*....|..
gi 62862008 403 TYL-HRIGRTGR 413
Cdd:cd18790 114 TSLiQTIGRAAR 125
SF2_C_Ski2 cd18795
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ...
 315-413 1.66e-04

C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350182 [Multi-domain]  Cd Length: 154  Bit Score: 41.77  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 315 GQAIIFCHTKRTAAWLAAKMTSDG-HSVAVLTGDLTVVQRLdvldrFRSGLEKVLITTNILSRGID-------IEQVTIV 386
Cdd:cd18795  44 KPVLVFCSSRKECEKTAKDLAGIAfHHAGLTREDRELVEEL-----FREGLIKVLVATSTLAAGVNlpartviIKGTQRY 118

                        90       100
                ....*....|....*....|....*..
gi 62862008 387 VNFDLpVDLDGMadceTYLHRIGRTGR 413
Cdd:cd18795 119 DGKGY-RELSPL----EYLQMIGRAGR 140
PRK13766 PRK13766
Hef nuclease; Provisional
 266-413 8.01e-04

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 41.78  E-value: 8.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  266 ARLIVADPTIIRLMREEEslenikqyyvKCKNEEGKYNA----IQNIYGCISVGQAIIFCHTKRTAAWLAAKMTSDGHSV 341
Cdd:PRK13766 323 SKRLVEDPRFRKAVRKAK----------ELDIEHPKLEKlreiVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKA 392

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  342 AVLTGD--------LTVVQRLDVLDRFRSGLEKVLITTNILSRGIDIEQVTIVVnFDLPVDLDGMAdcetyLHRIGRTGR 413
Cdd:PRK13766 393 VRFVGQaskdgdkgMSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVI-FYEPVPSEIRS-----IQRKGRTGR 466
SF2_C_EcoAI-like cd18799
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ...
 317-393 1.72e-03

C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350186 [Multi-domain]  Cd Length: 116  Bit Score: 37.92  E-value: 1.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 317 AIIFCHTKRTAAWLAAKMTSDGHSVAVLTGDLTVVQRLDV---LDRFRSGLEKVLITTNILSRGIDIEQVTIVVnFDLPV 393
Cdd:cd18799   9 TLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGDEaliLLFFGELKPPILVTVDLLTTGVDIPEVDNVV-FLRPT 87
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 98-267 3.97e-03

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 38.01  E-value: 3.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  98 KIQETALPTLLADPpQNMIAQSQSGTGKTAAFVLAMLSRVNVCLNhpQVLCLSPTYELAiqtgevaarmGQFCREIKLRF 177
Cdd:cd17921   4 PIQREALRALYLSG-DSVLVSAPTSSGKTLIAELAILRALATSGG--KAVYIAPTRALV----------NQKEADLRERF 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 178 AVRGEEV---------DRSKKIEEHILIGTPGKLLDWGIKFRLFDMKKISVFVLDEADVMIatQGH-----HDQCIRIhK 243
Cdd:cd17921  71 GPLGKNVglltgdpsvNKLLLAEADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAHLIG--DGErgvvlELLLSRL-L 147

                       170       180
                ....*....|....*....|....
gi 62862008 244 MLNPHCQMLFFSATYGkEVMDFAR 267
Cdd:cd17921 148 RINKNARFVGLSATLP-NAEDLAE 170
DEXHc_HFM1 cd18023
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ...
 93-282 6.02e-03

DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350781 [Multi-domain]  Cd Length: 206  Bit Score: 38.11  E-value: 6.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008  93 FNtpsKIQETALPTLL-ADppQNMIAQSQSGTGKTAAFVLAML----SRVNVCLNHPQVLCLSPTYELAIQT-GEVAARM 166
Cdd:cd18023   2 FN---RIQSEVFPDLLySD--KNFVVSAPTGSGKTVLFELAILrllkERNPLPWGNRKVVYIAPIKALCSEKyDDWKEKF 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62862008 167 GQfcreIKLRFA-VRGE-EVDRSKKIEE-HILIGTPGKlLD-----WGIKFRLFDMkkISVFVLDEADVMIATQGHHDQC 238
Cdd:cd18023  77 GP----LGLSCAeLTGDtEMDDTFEIQDaDIILTTPEK-WDsmtrrWRDNGNLVQL--VALVLIDEVHIIKENRGATLEV 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62862008 239 I--RI-------HKMLNPHCQMLF--FSATYgKEVMDFARLIVADPTIIRLMREE 282
Cdd:cd18023 150 VvsRMktlssssELRGSTVRPMRFvaVSATI-PNIEDLAEWLGDNPAGCFSFGES 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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