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Conserved domains on  [gi|442634512|ref|NP_001015258|]
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uncharacterized protein Dmel_CG12061, isoform F [Drosophila melanogaster]

Protein Classification

sodium:calcium antiporter( domain architecture ID 11424992)

sodium:calcium antiporter facilitates Na(+)/Ca(2+) exchange

Gene Ontology:  GO:0008273|GO:0006874
PubMed:  22287543|23506883
SCOP:  4006475
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
23-350 1.75e-45

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


:

Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 157.60  E-value: 1.75e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  23 VAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWYLIAIASLTY 102
Cdd:COG0530   21 VIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-PLAVDRRVLRRDLPFLLLASLLLLA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 103 VLWDSLVMWYEAFALLLLYISYVIQLSFDRRiqnlvrhEHAESELLDEDPMTREEEPLKgfrdhvcakpkteynfyqwtw 182
Cdd:COG0530  100 LLLDGTLSRIDGVILLLLYVLYLYYLIRRAR-------KEPAWEEVEEELEEKPKMSLW--------------------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 183 waikypaelmlactvpsaRSIFFLSMISAILWISliSYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSK 262
Cdd:COG0530  152 ------------------KALLLLVLGLALLVVG--ARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAAR 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 263 KGYGSMAICNAIGSNTFDILVCLGLPWLLkiliyqQKIDIDSTALTITTAMLVVTaAVLYLGLLARRFVMGKTVGYLSII 342
Cdd:COG0530  212 KGEDDLAVGNIIGSNIFNILLVLGIGALI------TPIPVDPAVLSFDLPVMLAA-TLLLLGLLRTGGRIGRWEGLLLLA 284


                 ....*...
gi 442634512 343 FYALFLII 350
Cdd:COG0530  285 LYLAYLAL 292
 
Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
23-350 1.75e-45

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 157.60  E-value: 1.75e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  23 VAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWYLIAIASLTY 102
Cdd:COG0530   21 VIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-PLAVDRRVLRRDLPFLLLASLLLLA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 103 VLWDSLVMWYEAFALLLLYISYVIQLSFDRRiqnlvrhEHAESELLDEDPMTREEEPLKgfrdhvcakpkteynfyqwtw 182
Cdd:COG0530  100 LLLDGTLSRIDGVILLLLYVLYLYYLIRRAR-------KEPAWEEVEEELEEKPKMSLW--------------------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 183 waikypaelmlactvpsaRSIFFLSMISAILWISliSYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSK 262
Cdd:COG0530  152 ------------------KALLLLVLGLALLVVG--ARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAAR 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 263 KGYGSMAICNAIGSNTFDILVCLGLPWLLkiliyqQKIDIDSTALTITTAMLVVTaAVLYLGLLARRFVMGKTVGYLSII 342
Cdd:COG0530  212 KGEDDLAVGNIIGSNIFNILLVLGIGALI------TPIPVDPAVLSFDLPVMLAA-TLLLLGLLRTGGRIGRWEGLLLLA 284


                 ....*...
gi 442634512 343 FYALFLII 350
Cdd:COG0530  285 LYLAYLAL 292
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 14-349 3.19e-39

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 141.31  E-value: 3.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   14 GNALRMTYDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWY 93
Cdd:TIGR00367  29 ARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFS-PIIVDKDWLRRDILFY 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   94 LIAIASLTYVLWDSLVMWYEAFALLLLYISYviqLSFDRRIQNLVRHEHAESELLDEDpmtrEEEPLKGFRdhvcakpkt 173
Cdd:TIGR00367 108 LLVSILLLFFGLDGQISRIDGVVLLILYIVY---LLFLVKNERWVKYDTYTEENLDEN----NRRPQIFFS--------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  174 eynfyqwtwwaikypaelmlactvpsarsifFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPE 253
Cdd:TIGR00367 172 -------------------------------LVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  254 VASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLPWLLKiliyqqKIDIDSTALTITTAMLVVTAAVLYLgLLARRFVMG 333
Cdd:TIGR00367 221 LVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFM------PIPVEPLAYNLDAPVMVIVTLLLML-FFKTSMKLG 293

                         330
                  ....*....|....*.
gi 442634512  334 KTVGylsIIFYALFLI 349
Cdd:TIGR00367 294 RWEG---ILLLALYIA 306
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 203-351 8.98e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 90.35  E-value: 8.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  203 IFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDIL 282
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442634512  283 VCLGLPWLLKILIYQQKIDIDSTALTITTAMLVVTAAVLYLGLLARRfvMGKTVGYLSIIFYALFLIIA 351
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLFGR--LSRFEGLVLLLLYIVYLVFQ 147
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 25-339 1.77e-15

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 76.22  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  25 GATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFtQPTKLDWWPVTRDTAWYLIAIASLTYVL 104
Cdd:PRK10734  41 GMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALI-RPFTVHSDVLRRELPLMLLVSVLAGSVL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 105 WDSLVMWYEAFALLLLYISYVIqlsFDRRIQNLVRHEhaesellDEDPMTREEEplkgfrdhvcakpkteynfyqwtwwa 184
Cdd:PRK10734 120 YDGQLSRSDGIFLLLLAVLWLL---FIVKIARLAERQ-------GNDSLTREQL-------------------------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 185 ikypAELmlacTVPSARSIFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKG 264
Cdd:PRK10734 164 ----AEL----PREGGLPVAFLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKG 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442634512 265 YGSMAICNAIGSNTFDILVCLGLPWLLkiliyqQKIDIDSTALTITTAMLVVTAAVLYLGLLARRFVMGKTVGYL 339
Cdd:PRK10734 236 ENDIAVGNIIGSNIFNIVIVLGLPALI------SPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGAL 304
 
Name Accession Description Interval E-value
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
23-350 1.75e-45

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 157.60  E-value: 1.75e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  23 VAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWYLIAIASLTY 102
Cdd:COG0530   21 VIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR-PLAVDRRVLRRDLPFLLLASLLLLA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 103 VLWDSLVMWYEAFALLLLYISYVIQLSFDRRiqnlvrhEHAESELLDEDPMTREEEPLKgfrdhvcakpkteynfyqwtw 182
Cdd:COG0530  100 LLLDGTLSRIDGVILLLLYVLYLYYLIRRAR-------KEPAWEEVEEELEEKPKMSLW--------------------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 183 waikypaelmlactvpsaRSIFFLSMISAILWISliSYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSK 262
Cdd:COG0530  152 ------------------KALLLLVLGLALLVVG--ARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAAR 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 263 KGYGSMAICNAIGSNTFDILVCLGLPWLLkiliyqQKIDIDSTALTITTAMLVVTaAVLYLGLLARRFVMGKTVGYLSII 342
Cdd:COG0530  212 KGEDDLAVGNIIGSNIFNILLVLGIGALI------TPIPVDPAVLSFDLPVMLAA-TLLLLGLLRTGGRIGRWEGLLLLA 284


                 ....*...
gi 442634512 343 FYALFLII 350
Cdd:COG0530  285 LYLAYLAL 292
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 14-349 3.19e-39

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 141.31  E-value: 3.19e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   14 GNALRMTYDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWY 93
Cdd:TIGR00367  29 ARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFS-PIIVDKDWLRRDILFY 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   94 LIAIASLTYVLWDSLVMWYEAFALLLLYISYviqLSFDRRIQNLVRHEHAESELLDEDpmtrEEEPLKGFRdhvcakpkt 173
Cdd:TIGR00367 108 LLVSILLLFFGLDGQISRIDGVVLLILYIVY---LLFLVKNERWVKYDTYTEENLDEN----NRRPQIFFS--------- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  174 eynfyqwtwwaikypaelmlactvpsarsifFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPE 253
Cdd:TIGR00367 172 -------------------------------LVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPE 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  254 VASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLPWLLKiliyqqKIDIDSTALTITTAMLVVTAAVLYLgLLARRFVMG 333
Cdd:TIGR00367 221 LVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFM------PIPVEPLAYNLDAPVMVIVTLLLML-FFKTSMKLG 293

                         330
                  ....*....|....*.
gi 442634512  334 KTVGylsIIFYALFLI 349
Cdd:TIGR00367 294 RWEG---ILLLALYIA 306
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 17-141 2.78e-33

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 131.27  E-value: 2.78e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512    17 LRMTYDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTQPT-KLDWWPVTRDTAWYLI 95
Cdd:TIGR00927  490 LQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREIlNLTWWPLFRDVSFYIL 569

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 442634512    96 AIASLTYVLWDSLVMWYEAFALLLLYISYVIQLSFDRRIQNLVRHE 141
Cdd:TIGR00927  570 DLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQ 615
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 188-355 8.37e-33

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 129.73  E-value: 8.37e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   188 PAELMLACTVP-----SARSIFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSK 262
Cdd:TIGR00927  913 PIVFPLWLTVPdvrrqEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVAR 992

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   263 KGYGSMAICNAIGSNTFDILVCLGLPWLLKILIYQ-QKIDIDSTALTITTAMLVVTAAVLYLGLLARRFVMGKTVGYLSI 341
Cdd:TIGR00927  993 KGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGlQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMF 1072

                          170
                   ....*....|....
gi 442634512   342 IFYALFLIIACTLE 355
Cdd:TIGR00927 1073 LLYFVFLIISVMLE 1086
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 203-351 8.98e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 90.35  E-value: 8.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  203 IFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDIL 282
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442634512  283 VCLGLPWLLKILIYQQKIDIDSTALTITTAMLVVTAAVLYLGLLARRfvMGKTVGYLSIIFYALFLIIA 351
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLFGR--LSRFEGLVLLLLYIVYLVFQ 147
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 25-339 1.77e-15

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 76.22  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  25 GATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFtQPTKLDWWPVTRDTAWYLIAIASLTYVL 104
Cdd:PRK10734  41 GMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALI-RPFTVHSDVLRRELPLMLLVSVLAGSVL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 105 WDSLVMWYEAFALLLLYISYVIqlsFDRRIQNLVRHEhaesellDEDPMTREEEplkgfrdhvcakpkteynfyqwtwwa 184
Cdd:PRK10734 120 YDGQLSRSDGIFLLLLAVLWLL---FIVKIARLAERQ-------GNDSLTREQL-------------------------- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 185 ikypAELmlacTVPSARSIFFLSMISAILWISLISYLLTWFLTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKG 264
Cdd:PRK10734 164 ----AEL----PREGGLPVAFLWLGIALIIMPMATRMVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKG 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442634512 265 YGSMAICNAIGSNTFDILVCLGLPWLLkiliyqQKIDIDSTALTITTAMLVVTAAVLYLGLLARRFVMGKTVGYL 339
Cdd:PRK10734 236 ENDIAVGNIIGSNIFNIVIVLGLPALI------SPGEINPLAFSRDYWVMLLVSVIFALLCWRRKRRIGRGAGAL 304
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 14-126 2.96e-13

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 66.47  E-value: 2.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   14 GNALRMTYDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFT------QPTKLDwWPVT 87
Cdd:pfam01699  28 ARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSALIGpvkvdsLLLKLD-LGVL 106

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442634512   88 RDTAWYLIAIASLTYVLWDSLVMWYEAFALLLLYISYVI 126
Cdd:pfam01699 107 LLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLV 145
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
23-128 2.29e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 66.70  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  23 VAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWYLIAIASLTY 102
Cdd:COG0530  188 VIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALIT-PIPVDPAVLSFDLPVMLAATLLLLG 266

                         90       100
                 ....*....|....*....|....*..
gi 442634512 103 VLWDSLVM-WYEAFALLLLYISYVIQL 128
Cdd:COG0530  267 LLRTGGRIgRWEGLLLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
229-351 3.06e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 66.31  E-value: 3.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 229 LGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLPWLLKiliyqqKIDIDSTALT 308
Cdd:COG0530   11 LARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR------PLAVDRRVLR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 442634512 309 ITTAMLVVTAAVLYLGLLARRFvmGKTVGYLSIIFYALFLIIA 351
Cdd:COG0530   85 RDLPFLLLASLLLLALLLDGTL--SRIDGVILLLLYVLYLYYL 125
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 226-316 8.95e-09

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 56.18  E-value: 8.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  226 LTILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLPWLL-KILIYQQKIDIDS 304
Cdd:TIGR00367  25 SVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFsPIIVDKDWLRRDI 104

                          90
                  ....*....|..
gi 442634512  305 TALTITTAMLVV 316
Cdd:TIGR00367 105 LFYLLVSILLLF 116
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 228-349 4.72e-08

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 53.88  E-value: 4.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512 228 ILGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKGYGSMAICNAIGSNTFDILVCLGLPWLLKILIYQQKIDIDSTAL 307
Cdd:PRK10734  28 ILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVHSDVLRRELPL 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442634512 308 tittaMLVVTA---AVLYLGLLARrfvMGKTVGYLSIIFYALFLI 349
Cdd:PRK10734 108 -----MLLVSVlagSVLYDGQLSR---SDGIFLLLLAVLWLLFIV 144
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 14-124 9.66e-08

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 53.10  E-value: 9.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   14 GNALRMTYDVAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWY 93
Cdd:TIGR00367 197 AEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFM-PIPVEPLAYNLDAPVM 275

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442634512   94 LIAIASLTYVLWDSLVM-WYEAFALLLLYISY 124
Cdd:TIGR00367 276 VIVTLLLMLFFKTSMKLgRWEGILLLALYIAY 307
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 11-72 2.32e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 49.41  E-value: 2.32e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512   11 KPNGNALRMTY-----DVAGATFLAASTSAPELF---VNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVC 72
Cdd:TIGR00845 114 KPNGETTVTTVriwneTVSNLTLMALGSSAPEILlsvIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAIC 183
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 23-105 4.15e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 45.02  E-value: 4.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  23 VAGATFLAASTSAPELFVNFVGTFVTNGDIGLGTIVGSSVFNILVIAGVCGIFTqPTKLDWWPVTRDTAWYLIAIASLTY 102
Cdd:PRK10734 210 TIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS-PGEINPLAFSRDYWVMLLVSVIFAL 288


                 ...
gi 442634512 103 VLW 105
Cdd:PRK10734 289 LCW 291
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 15-149 4.88e-05

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 45.14  E-value: 4.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  15 NALRMTYDVAGATFLAASTSAPELFVN---FVGTfvTNGDIGLGTIVGSSVFNILVIAGVC--GIFTQPTKLDWWPVTRD 89
Cdd:PLN03151 171 KLLRLPPTVAGVTLLPLGNGAPDVFASiaaFVGK--DAGEVGLNSVLGGAVFVTCVVVGIVslCVADKEVQIDKRCFIRD 248

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  90 TAWYLIAIASLTYVLWDSLVMWYEAFALLLLYISYVIQLSfdrriQNLVRHEHAESELLD 149
Cdd:PLN03151 249 LCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVA-----ANEILRKHARRLKLD 303
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 149-329 7.82e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 44.78  E-value: 7.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  149 DEDPMTREEEPLKGFRDHV------------CAKPKTEYnfyqWTWWAikypaelmlaCTVPSarsIFFLSMISAIlwis 216
Cdd:TIGR00845 714 DDDDDEDGEEKLPSCFDYVmhfltvfwkvlfAFVPPTEY----WGGWA----------CFVVS---ILMIGVLTAF---- 772

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634512  217 lISYLLTWFltilGYNLNIPDAIMGLTVLAAGTSVPEVASSYIVSKKG-YGSMAICNAIGSNTFDILVCLGLPWLLKIlI 295
Cdd:TIGR00845 773 -IGDLASHF----GCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDqYADASIGNVTGSNAVNVFLGIGVAWSIAA-I 846

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 442634512  296 YQ----QKIDIDSTALTITTAMLVVTAAVLYLGLLARR 329
Cdd:TIGR00845 847 YHaangTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRR 884
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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