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Conserved domains on  [gi|62868225|ref|NP_001017390|]
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sulfotransferase 1A4 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-287 2.69e-105

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 306.96  E-value: 2.69e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225    38 PDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYV---RVPFLEVNDPGE----PSGLETLKDTPPPRLIKSHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGDTyfdvAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   111 LALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   191 LFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQElmdhsISPFMRKGMAGDWKTTFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 62868225   271 AQNERFDADYAEKMAGC 287
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-287 2.69e-105

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 306.96  E-value: 2.69e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225    38 PDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYV---RVPFLEVNDPGE----PSGLETLKDTPPPRLIKSHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGDTyfdvAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   111 LALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   191 LFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQElmdhsISPFMRKGMAGDWKTTFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 62868225   271 AQNERFDADYAEKMAGC 287
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-289 3.71e-30

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 116.17  E-value: 3.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   34 FQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRaPIYVR-----VPFLEVNDPGEPSgLETLKDTPPPrLIKSH 108
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225  109 LPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAH--PEPGTWDSFlEKFMAGEVSYGSWYQHVQEWWELSRTH 186
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQEN 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225  187 P--VLYLFYEDMKENPKREIQKILEFVGRSLPEE-----TMDFMVQHTSFkEMKKNPMTNYTTVPQELMD--HSISPFMR 257
Cdd:PLN02164 231 PdrILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFR 309

                        250       260       270
                 ....*....|....*....|....*....|..
gi 62868225  258 KGMAGDWKTTFTVAQNERFDADYAEKMAGCSL 289
Cdd:PLN02164 310 KGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
38-287 2.69e-105

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 306.96  E-value: 2.69e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225    38 PDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYV---RVPFLEVNDPGE----PSGLETLKDTPPPRLIKSHLP 110
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLFNnhnRSPFLEWYPGDTyfdvAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   111 LALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLY 190
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   191 LFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQElmdhsISPFMRKGMAGDWKTTFTV 270
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKE-----VSPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*..
gi 62868225   271 AQNERFDADYAEKMAGC 287
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 34-289 3.71e-30

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 116.17  E-value: 3.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   34 FQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRaPIYVR-----VPFLEVNDPGEPSgLETLKDTPPPrLIKSH 108
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225  109 LPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAH--PEPGTWDSFlEKFMAGEVSYGSWYQHVQEWWELSRTH 186
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQqgPLNSLEESF-DMFCRGLSVYGPYLDHVLGYWKAYQEN 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225  187 P--VLYLFYEDMKENPKREIQKILEFVGRSLPEE-----TMDFMVQHTSFkEMKKNPMTNYTTVPQELMD--HSISPFMR 257
Cdd:PLN02164 231 PdrILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSF-ETLKNLEANKGEKDREDRPavYANSAYFR 309

                        250       260       270
                 ....*....|....*....|....*....|..
gi 62868225  258 KGMAGDWKTTFTVAQNERFDADYAEKMAGCSL 289
Cdd:PLN02164 310 KGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
47-217 6.23e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 54.22  E-value: 6.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225    47 PKSGTTWVSQILD---------------------MIYQGGDLEKCNRAPIYVRVpFLEVNdpgePSGLETLKdtppprLI 105
Cdd:pfam13469   7 PRSGTTLLHRLLAahpdvrppeetwfviprilalLQAWGKSLEALARVPSYARW-LCDKS----PSHLFHLD------LL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62868225   106 KSHLPLAllpqtlldqkvKVVYVARNPKDVAV-SYYHFHRMEKAhpepgTWDSFLEKFMAGEVSYgsWYQHVQEWWELSR 184
Cdd:pfam13469  76 LKAFPDA-----------KFIHLHRDPVDTVIsSYCSLFGFTLS-----SYSTAFLRDIGLALAR--WSRAYERLMAARA 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 62868225   185 THP---VLYLFYEDMKENPKREIQKILEFVGRSLPE 217
Cdd:pfam13469 138 RVPpgrFLDVRYEDLVADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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