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Conserved domains on  [gi|64762402|ref|NP_001018068|]
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transcription factor EC isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 107-191 2.55e-53

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


:

Pssm-ID: 381495  Cd Length: 85  Bit Score: 169.49  E-value: 2.55e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 107 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 186
Cdd:cd18925   1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 80


                ....*
gi 64762402 187 LLLRI 191
Cdd:cd18925  81 LLLRI 85
DUF3371 pfam11851
Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain ...
 196-315 8.04e-29

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.


:

Pssm-ID: 463372  Cd Length: 128  Bit Score: 107.50  E-value: 8.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402   196 IQARTHGLPTLAS--LGTVDLGAHVTKQQ-SHPEQNSVDYCQ-------QLTVSQGPSPELCDQAIAFSdplsyFTDL-- 263
Cdd:pfam11851   1 MQARAHGLPVASSsgLCTAELAARVIKQEpALPPCPPDLYDMsqpqpptQAAVSSSSTLDLNDGLITFS-----FGDLsa 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 64762402   264 SFSAALKEEQRLDGMLLDDTISPFG-TDPLLSATSPAVSKESSRRSSFSSDDG 315
Cdd:pfam11851  76 SFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSRRSSFSMEEG 128
 
Name Accession Description Interval E-value
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 107-191 2.55e-53

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 169.49  E-value: 2.55e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 107 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 186
Cdd:cd18925   1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 80


                ....*
gi 64762402 187 LLLRI 191
Cdd:cd18925  81 LLLRI 85
DUF3371 pfam11851
Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain ...
 196-315 8.04e-29

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.


Pssm-ID: 463372  Cd Length: 128  Bit Score: 107.50  E-value: 8.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402   196 IQARTHGLPTLAS--LGTVDLGAHVTKQQ-SHPEQNSVDYCQ-------QLTVSQGPSPELCDQAIAFSdplsyFTDL-- 263
Cdd:pfam11851   1 MQARAHGLPVASSsgLCTAELAARVIKQEpALPPCPPDLYDMsqpqpptQAAVSSSSTLDLNDGLITFS-----FGDLsa 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 64762402   264 SFSAALKEEQRLDGMLLDDTISPFG-TDPLLSATSPAVSKESSRRSSFSSDDG 315
Cdd:pfam11851  76 SFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSRRSSFSMEEG 128
HLH smart00353
helix loop helix domain;
116-168 2.16e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 35.66  E-value: 2.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 64762402    116 NLIERRRRYNINYRIKELGTLIPkSNDPDMRWNKGTILKASVEYIKWLQKEQQ 168
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLP-TLPKNKKLSKAEILRLAIEYIKSLQEELQ 52
 
Name Accession Description Interval E-value
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 107-191 2.55e-53

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 169.49  E-value: 2.55e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 107 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 186
Cdd:cd18925   1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 80


                ....*
gi 64762402 187 LLLRI 191
Cdd:cd18925  81 LLLRI 85
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
 99-202 1.35e-50

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 162.95  E-value: 1.35e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402  99 ETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQK 178
Cdd:cd18926   1 ESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQK 80

                        90       100
                ....*....|....*....|....
gi 64762402 179 KLEQANRRLLLRIQELEIQARTHG 202
Cdd:cd18926  81 KLEHANRHLLLRIQELEMQARAHG 104
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 101-191 1.61e-41

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 139.41  E-value: 1.61e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 101 DTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKL 180
Cdd:cd18928   1 EAKAFLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSTDPEMRWNKGTILKASVDYIRKLQKEQQRSKEIEMRQRKL 80

                        90
                ....*....|.
gi 64762402 181 EQANRRLLLRI 191
Cdd:cd18928  81 EQANRSLQLRI 91
bHLHzip_TFEB cd18927
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and ...
 101-191 3.94e-39

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins; TFEB, also termed Class E basic helix-loop-helix protein 35 (bHLHe35), is a bHLHzip transcription factor that is required for vascularization of the mouse placenta. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF.


Pssm-ID: 381497  Cd Length: 91  Bit Score: 133.18  E-value: 3.94e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 101 DTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKL 180
Cdd:cd18927   1 EARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKTNDLDVRWNKGTILKASVDYIKRMQKDLQRSRELENHSRRL 80

                        90
                ....*....|.
gi 64762402 181 EQANRRLLLRI 191
Cdd:cd18927  81 EMTNKQLWLRI 91
bHLHzip_MITF_like cd11397
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated ...
 107-175 1.77e-35

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family; The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381403  Cd Length: 69  Bit Score: 122.79  E-value: 1.77e-35
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 64762402 107 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEH 175
Cdd:cd11397   1 KDRQKKDNHNMIERRRRFNINDRIKELGTLLPKSNDPDMRWNKGTILKASVDYIRKLQKEQERLRQLEE 69
DUF3371 pfam11851
Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain ...
 196-315 8.04e-29

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.


Pssm-ID: 463372  Cd Length: 128  Bit Score: 107.50  E-value: 8.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402   196 IQARTHGLPTLAS--LGTVDLGAHVTKQQ-SHPEQNSVDYCQ-------QLTVSQGPSPELCDQAIAFSdplsyFTDL-- 263
Cdd:pfam11851   1 MQARAHGLPVASSsgLCTAELAARVIKQEpALPPCPPDLYDMsqpqpptQAAVSSSSTLDLNDGLITFS-----FGDLsa 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 64762402   264 SFSAALKEEQRLDGMLLDDTISPFG-TDPLLSATSPAVSKESSRRSSFSSDDG 315
Cdd:pfam11851  76 SFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSRRSSFSMEEG 128
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 114-169 1.38e-10

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 56.11  E-value: 1.38e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 64762402 114 NHNLIERRRRYNINYRIKELGTLIPKSND--PDMRWNKGTILKASVEYIKWLQKEQQR 169
Cdd:cd11387   1 SHNAVERRRRDNINEKIQELGSLVPPSRLetKDLKPNKGSILSKAVEYIRELQNQNQE 58
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 107-193 7.41e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 49.26  E-value: 7.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 107 KERQKKDNHNLIERRRRYNINYRIKELGTLIPkSNDPDMrwNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRR 186
Cdd:cd11398   3 WHRQRRDNHKEVERRRRENINEGINELAALVP-GNAREK--NKGAILARAVEYIQELQETEAKNIEKWTLEKLLTDQAIA 79


                ....*..
gi 64762402 187 LLLRIQE 193
Cdd:cd11398  80 ELAALNE 86
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 107-187 1.65e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400 [Multi-domain]  Cd Length: 73  Bit Score: 39.56  E-value: 1.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 107 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKsndPDMRWNKGTILKASVEYIkwlqkeqqraRELEHRQKKLEQANRR 186
Cdd:cd11394   2 PKVEKRSAHNAIEKRYRSSINDRIIELKDLVVG---PDAKMNKSAVLRKAIDYI----------RYLQKVNQKLKQENMA 68


                .
gi 64762402 187 L 187
Cdd:cd11394  69 L 69
bHLHzip_SREBP2 cd18922
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 107-172 4.36e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins; SREBP2, also termed Class D basic helix-loop-helix protein 2 (bHLHd2), or sterol regulatory element-binding transcription factor 2 (SREBF2), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcription activator of cholesterol biosynthesis.


Pssm-ID: 381492 [Multi-domain]  Cd Length: 77  Bit Score: 38.40  E-value: 4.36e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 64762402 107 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKSndpDMRWNKGTILKASVEYIKWLQKEQQRARE 172
Cdd:cd18922   2 KEGERRTTHNIIEKRYRSSINDKIIELKDLVMGT---DAKMHKSGVLRKAIDYIKYLQQVNHKLRQ 64
bHLHzip_SREBP1 cd18921
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 110-193 1.76e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins; SREBP1, also termed Class D basic helix-loop-helix protein 1 (bHLHd1), or sterol regulatory element-binding transcription factor 1 (SREBF1), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcriptional activator required for lipid homeostasis. It may control transcription of the low-density lipoprotein receptor gene as well as the fatty acid. SREBP1 has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').


Pssm-ID: 381491  Cd Length: 75  Bit Score: 36.41  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 110 QKKDNHNLIERRRRYNINYRIKELGTLIPksnDPDMRWNKGTILKASVEYIKWLQKEQQrarelehrqkKLEQANRRLLL 189
Cdd:cd18921   5 EKRTAHNAIEKRYRSSINDKIIELKDLVV---GTEAKLNKSAVLRKAIDYIRFLQQSNQ----------KLKQENMALKM 71


                ....
gi 64762402 190 RIQE 193
Cdd:cd18921  72 AVQK 75
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 149-194 2.12e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 36.37  E-value: 2.12e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 64762402 149 KGTILKASVEYIKWLQKEQqraRELEHRQKKLEQANRRLLLRIQEL 194
Cdd:cd11400  38 KVVILKKATEYIKQLQQEE---KKLEKEKDKLKARNEQLRKKLERL 80
HLH smart00353
helix loop helix domain;
116-168 2.16e-03

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 35.66  E-value: 2.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 64762402    116 NLIERRRRYNINYRIKELGTLIPkSNDPDMRWNKGTILKASVEYIKWLQKEQQ 168
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLP-TLPKNKKLSKAEILRLAIEYIKSLQEELQ 52
bHLHzip_scHMS1_like cd11399
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription ...
 109-181 4.27e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.


Pssm-ID: 381405 [Multi-domain]  Cd Length: 96  Bit Score: 35.91  E-value: 4.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 64762402 109 RQKKDNHNLIER------------------------RRRYNINYRIKELGTLIPKSndpdmRWNKGTILKASVEYIKWLQ 164
Cdd:cd11399   1 PSKKTAHNMIEKryrsnindriaelrdsvpalreayKSARGEDEDEEDLGGLTPAT-----KLNKATILSKATEYIRHLE 75

                        90
                ....*....|....*...
gi 64762402 165 -KEQQRARELEHRQKKLE 181
Cdd:cd11399  76 kKNKRLSRENASLRERLA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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