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Conserved domains on  [gi|66472792|ref|NP_001018607|]
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interleukin-1 receptor-associated kinase 1-binding protein 1 homolog [Danio rerio]

Protein Classification

SIMPL domain-containing protein( domain architecture ID 10516460)

SIMPL domain-containing protein similar to Homo sapiens interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1), a component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival

CATH:  3.30.70.2970|3.30.110.170
PubMed:  11096118
SCOP:  4004729

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 46-190 1.52e-17

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


:

Pssm-ID: 461292  Cd Length: 159  Bit Score: 76.96  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472792    46 IEVTGCAEISSPPDRACVSISVKNSKENVNDVTNSVTRRLEYILQTAR-QHDVKEENITVT----------KHLQRDEDL 114
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKkAAGIPEKDIQTSgyslypvydyKNGKRKITG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66472792   115 FHMQAEVLVVFLDFEKMQQARTVLIEKLDKSvcVGDPYYSHSAEslSLLRRRVCLEAVDNARLKASEACCTLGQAL 190
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEAGANR--IDGVSFSLSDE--DELRAEARAEAVADARAKAEALAKALGLKL 152
 
Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 46-190 1.52e-17

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


Pssm-ID: 461292  Cd Length: 159  Bit Score: 76.96  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472792    46 IEVTGCAEISSPPDRACVSISVKNSKENVNDVTNSVTRRLEYILQTAR-QHDVKEENITVT----------KHLQRDEDL 114
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKkAAGIPEKDIQTSgyslypvydyKNGKRKITG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66472792   115 FHMQAEVLVVFLDFEKMQQARTVLIEKLDKSvcVGDPYYSHSAEslSLLRRRVCLEAVDNARLKASEACCTLGQAL 190
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEAGANR--IDGVSFSLSDE--DELRAEARAEAVADARAKAEALAKALGLKL 152
YggE COG2968
Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function ...
 38-194 1.01e-09

Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function unknown];


Pssm-ID: 442208  Cd Length: 234  Bit Score: 56.82  E-value: 1.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472792  38 SAQSNVRVIEVTGCAEISSPPDRACVSISVKNSKENVNDVTNSVTRRLEYILQTARQHDVKEENI-----TVTKHLQRDE 112
Cdd:COG2968  22 AEAPDEPTITVSGEGEVEVAPDIATVSLGVETEGKTAAEALAENAERMAAVIAALKAAGIAEEDIqtsnlSVQPEYDYDK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472792 113 DL------FHMQAEVLVVFLDFEKMQQartvLIEKLDKS--VCVGDPYYSHSAESLslLRRRVCLEAVDNARLKASEACC 184
Cdd:COG2968 102 DGkpkltgYRASNTVTVTVRDLDKLGE----VLDAAVAAgaNRINGVSFGLSDPEA--LRDEARKAAVADARAKAEALAK 175

                       170
                ....*....|
gi 66472792 185 TLGQALGRPL 194
Cdd:COG2968 176 ALGVKLGRVL 185
 
Name Accession Description Interval E-value
SIMPL pfam04402
Protein of unknown function (DUF541); Members of this family have so far been found in ...
 46-190 1.52e-17

Protein of unknown function (DUF541); Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries. However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerization. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.


Pssm-ID: 461292  Cd Length: 159  Bit Score: 76.96  E-value: 1.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472792    46 IEVTGCAEISSPPDRACVSISVKNSKENVNDVTNSVTRRLEYILQTAR-QHDVKEENITVT----------KHLQRDEDL 114
Cdd:pfam04402   1 ITVSGTGEVEVAPDLATVTLGVETEGKDAAEAQAENAERMNAVLAALKkAAGIPEKDIQTSgyslypvydyKNGKRKITG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66472792   115 FHMQAEVLVVFLDFEKMQQARTVLIEKLDKSvcVGDPYYSHSAEslSLLRRRVCLEAVDNARLKASEACCTLGQAL 190
Cdd:pfam04402  81 YRASNSLTVTVRDLDKLGELLDAAVEAGANR--IDGVSFSLSDE--DELRAEARAEAVADARAKAEALAKALGLKL 152
YggE COG2968
Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function ...
 38-194 1.01e-09

Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain [Function unknown];


Pssm-ID: 442208  Cd Length: 234  Bit Score: 56.82  E-value: 1.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472792  38 SAQSNVRVIEVTGCAEISSPPDRACVSISVKNSKENVNDVTNSVTRRLEYILQTARQHDVKEENI-----TVTKHLQRDE 112
Cdd:COG2968  22 AEAPDEPTITVSGEGEVEVAPDIATVSLGVETEGKTAAEALAENAERMAAVIAALKAAGIAEEDIqtsnlSVQPEYDYDK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472792 113 DL------FHMQAEVLVVFLDFEKMQQartvLIEKLDKS--VCVGDPYYSHSAESLslLRRRVCLEAVDNARLKASEACC 184
Cdd:COG2968 102 DGkpkltgYRASNTVTVTVRDLDKLGE----VLDAAVAAgaNRINGVSFGLSDPEA--LRDEARKAAVADARAKAEALAK 175

                       170
                ....*....|
gi 66472792 185 TLGQALGRPL 194
Cdd:COG2968 176 ALGVKLGRVL 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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