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Conserved domains on  [gi|326633249|ref|NP_001020020|]
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novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 8.46e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.46e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 326633249    3 LITYDDVHVNFTQEEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-498 8.57e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 8.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 129 KPYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQ--CGKAFKRRSDLQIHKRTHTGEKPYEC-KQCGKAFVSSGELQKH 205
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 206 KRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQCGKAFARS----------------------GDLQKHKR 263
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 264 THTGEKPYECKQCGKAFAHSSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQ 343
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 344 MHKQTHTGE-------KPYECKQCGKTFSQSRHLRIHKRT--HTGE--KPYEC--NQCGKAFARSGDQQEHKRTHTGEKP 410
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 411 YEC--NQCGK----AFIRRRVLQIHKR-THTGEKPYEC--KQCGKAFASSSDLQKHKRTHSGEKPYECK--QCGKAFAQS 479
Cdd:COG5048  352 AKEklLNSSSkfspLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410
                 ....*....|....*....
gi 326633249 480 SHLRIHKQTHTGERPYECN 498
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 8.46e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.46e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 326633249    3 LITYDDVHVNFTQEEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
5-45 4.30e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 4.30e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 326633249     5 TYDDVHVNFTQEEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 2.17e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.17e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 326633249   4 ITYDDVHVNFTQEEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-498 8.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 8.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 129 KPYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQ--CGKAFKRRSDLQIHKRTHTGEKPYEC-KQCGKAFVSSGELQKH 205
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 206 KRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQCGKAFARS----------------------GDLQKHKR 263
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 264 THTGEKPYECKQCGKAFAHSSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQ 343
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 344 MHKQTHTGE-------KPYECKQCGKTFSQSRHLRIHKRT--HTGE--KPYEC--NQCGKAFARSGDQQEHKRTHTGEKP 410
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 411 YEC--NQCGK----AFIRRRVLQIHKR-THTGEKPYEC--KQCGKAFASSSDLQKHKRTHSGEKPYECK--QCGKAFAQS 479
Cdd:COG5048  352 AKEklLNSSSkfspLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410
                 ....*....|....*....
gi 326633249 480 SHLRIHKQTHTGERPYECN 498
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 2.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 326633249  201 ELQKHKRTHTGEKPYECKQCGKAFSQ 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 8.46e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 8.46e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 326633249    3 LITYDDVHVNFTQEEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
5-45 4.30e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 4.30e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 326633249     5 TYDDVHVNFTQEEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 2.17e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 2.17e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 326633249   4 ITYDDVHVNFTQEEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-498 8.57e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 8.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 129 KPYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQ--CGKAFKRRSDLQIHKRTHTGEKPYEC-KQCGKAFVSSGELQKH 205
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 206 KRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQCGKAFARS----------------------GDLQKHKR 263
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 264 THTGEKPYECKQCGKAFAHSSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQ 343
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 344 MHKQTHTGE-------KPYECKQCGKTFSQSRHLRIHKRT--HTGE--KPYEC--NQCGKAFARSGDQQEHKRTHTGEKP 410
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 411 YEC--NQCGK----AFIRRRVLQIHKR-THTGEKPYEC--KQCGKAFASSSDLQKHKRTHSGEKPYECK--QCGKAFAQS 479
Cdd:COG5048  352 AKEklLNSSSkfspLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410
                 ....*....|....*....
gi 326633249 480 SHLRIHKQTHTGERPYECN 498
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-497 1.04e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 1.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 197 VSSGELQKHKRTHTGE----KPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQ--CGKAFARSGDLQKHKRTHTGEKP 270
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 271 YECKQCGK--AFAHSSHLHIHErRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAF------------ 336
Cdd:COG5048   92 DLNSKSLPlsNSKASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpp 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 337 ----------TVIYTLQMHKQTHTGEKPYECKQCGKTFSQSRHLRIHKRTHTGEKPYECNQCGKAFARSGDQQEHKRT-- 404
Cdd:COG5048  171 lpanslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLss 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 405 ----HTGEKPYECNQCGKAFIRRRVLQIHKRTHTG-EKPYECKQCGKAFASSSDLQKHKRT--HSGE--KPYEC--KQCG 473
Cdd:COG5048  251 sdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCG 330

                        330       340
                 ....*....|....*....|....
gi 326633249 474 KAFAQSSHLRIHKQTHTGERPYEC 497
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
74-459 1.38e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249  74 PSEFIQCGKAFAYESGRQRHQIKHTGEKHHDCNQCGKD--FRTWNVLQIHKRTHTGEKPYDC-KQCGKAFARSCHLRIHN 150
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 151 RTHAGEKQYECNQCGKAFKRRSDLQIHKRTHTGEKPYECKQCGKAFVSS----------------------GELQKHKRT 208
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnslhpplpanslskdpssnLSLLISSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 209 HTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGEKPYECKQCG------KAFAH 282
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 283 SSHLHIHERRHTG-DKPYECKQCGKAFAVFYTLQMHKRT--HTG--DKPYEC--KQCGKAFTVIYTLQMHKQTHTGEKPY 355
Cdd:COG5048  273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 356 ECK--QCGKTFSQS----RHLRIHKR-THTGEKPYEC--NQCGKAFARSGDQQEHKRTHTGEKPYECN--QCGKAFIRRR 424
Cdd:COG5048  353 KEKllNSSSKFSPLlnnePPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHY 432

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 326633249 425 VLQIHKRTHTGEKPYECKQCGKaFASSSDLQKHKR 459
Cdd:COG5048  433 NLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 2.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 326633249  201 ELQKHKRTHTGEKPYECKQCGKAFSQ 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 2.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.69e-04
                          10        20
                  ....*....|....*....|....*.
gi 326633249  257 DLQKHKRTHTGEKPYECKQCGKAFAH 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 5.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 326633249  369 HLRIHKRTHTGEKPYECNQCGKAFAR 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 5.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 326633249  229 HLRIHKRTHTGEKPYECNQCGKAFAR 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 5.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 326633249  453 DLQKHKRTHSGEKPYECKQCGKAFAQ 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 9.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 326633249  173 DLQIHKRTHTGEKPYECKQCGKAFVS 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-450 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*
gi 326633249  426 LQIHKRTHTGEKPYECKQCGKAFAS 450
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-337 1.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|....
gi 326633249  314 LQMHKRTHTGDKPYECKQCGKAFT 337
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-366 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*
gi 326633249  342 LQMHKQTHTGEKPYECKQCGKTFSQ 366
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
RPL43A COG1997
Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 420-477 2.66e-03

Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Ribosomal protein L37AE/L43A is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441600  Cd Length: 87  Bit Score: 36.83  E-value: 2.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 326633249 420 FIRRRVLQIHKRTHtgeKPYECKQCGKafasssdlQKHKRTHSGekPYECKQCGKAFA 477
Cdd:COG1997   21 KLRKRVADIEEKMR---AKHTCPECGS--------KRVKRVATG--IWECRKCGYKFA 65
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 2.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*
gi 326633249  118 LQIHKRTHTGEKPYDCKQCGKAFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-422 3.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.23e-03
                          10        20
                  ....*....|....*....|....
gi 326633249  399 QEHKRTHTGEKPYECNQCGKAFIR 422
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
53-207 6.91e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 6.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249  53 EDHLQTSRSHGRHERSCSAEQPSEFIQCGKAFAYESGRQRHQIKHTGEKHHDC--NQCGKDFR----TWNVLQIHKR-TH 125
Cdd:COG5048  302 SSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnNEPPQSLQQYkDL 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 126 TGEKPYDC--KQCGKAFARSCHLRIHNRTHAGEKQYECN--QCGKAFKRRSDLQIHKRTHTGEKPYECKQCGKaFVSSGE 201
Cdd:COG5048  382 KNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLD 460


                 ....*.
gi 326633249 202 LQKHKR 207
Cdd:COG5048  461 LSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 211-296 8.99e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 8.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326633249 211 GEKPYECK--QCGKAFSQSSHLRIHKRThtgekpyecNQCGKAFARSGDLQKHKRTHTGEKPYECKQCGKAFAHSSHLHI 288
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*...
gi 326633249 289 HeRRHTGD 296
Cdd:COG5189  417 H-RKHSHD 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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