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Conserved domains on  [gi|71981558|ref|NP_001021028|]
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G1/S-specific cyclin-E [Caenorhabditis elegans]

Protein Classification

G1/S-specific cyclin-E( domain architecture ID 15334151)

G1/S-specific cyclin-E is essential for the control of the cell cycle at the G1/S (start) transition

Gene Ontology:  GO:0000082|GO:0016538|GO:0044772|GO:0097134

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 223-354 1.52e-75

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410223  Cd Length: 131  Bit Score: 234.13  E-value: 1.52e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 223 GIGSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVeCSTDN 302
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTN-VPKTQ 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 71981558 303 FQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20519  80 LQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 358-460 3.59e-29

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 110.83  E-value: 3.59e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 358 PITSIQWLSTYLQLLGTgkkNKSDHYEEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVLFVNYEPTCAV 437
Cdd:cd20520   1 PPTPNSWLNLYLQLAQL---NPPPKENDSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLVSPDDEAI 77

                        90       100
                ....*....|....*....|...
gi 71981558 438 EKATGFMQAQLEKVIEYVEPVCR 460
Cdd:cd20520  78 EQVTGYSWEQLAPCVEWMTPFAE 100
U2AF_lg super family cl36941
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 30-138 6.79e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


The actual alignment was detected with superfamily member TIGR01642:

Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.11  E-value: 6.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558    30 DELRERLletaidmKENIPQRNTRNSSVGSQKSDCSETRKRRSTKEGPAAKRHSGEKHRNGSREDSLEYISDDREVGSSS 109
Cdd:TIGR01642   2 DEEPDRE-------REKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRS 74

                          90       100
                  ....*....|....*....|....*....
gi 71981558   110 SQSSRTRGQPLPAMPEEEEVFDKSSSSDN 138
Cdd:TIGR01642  75 RDRPRRRSRSVRSIEQHRRRLRDRSPSNQ 103
 
Name Accession Description Interval E-value
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 223-354 1.52e-75

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 234.13  E-value: 1.52e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 223 GIGSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVeCSTDN 302
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTN-VPKTQ 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 71981558 303 FQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20519  80 LQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 230-357 1.14e-44

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 153.44  E-value: 1.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558   230 VWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTA 309
Cdd:pfam00134   2 IFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSV--PKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 71981558   310 ALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGWSLG 357
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 358-460 3.59e-29

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 110.83  E-value: 3.59e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 358 PITSIQWLSTYLQLLGTgkkNKSDHYEEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVLFVNYEPTCAV 437
Cdd:cd20520   1 PPTPNSWLNLYLQLAQL---NPPPKENDSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLVSPDDEAI 77

                        90       100
                ....*....|....*....|...
gi 71981558 438 EKATGFMQAQLEKVIEYVEPVCR 460
Cdd:cd20520  78 EQVTGYSWEQLAPCVEWMTPFAE 100
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
229-357 1.71e-18

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 87.91  E-value: 1.71e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 229 KVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECStdNFQLVGT 308
Cdd:COG5024 183 DIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLE--KYQLVGI 260

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 71981558 309 AALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGWSLG 357
Cdd:COG5024 261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 264-350 1.95e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.86  E-value: 1.95e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558    264 DWMMEVCESEKLHRETFHLAVDYVDRYLesSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDsaFTCDNIRT 343
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL--SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILR 76


                   ....*..
gi 71981558    344 MEVLIVK 350
Cdd:smart00385  77 MERLLLE 83
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 30-138 6.79e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.11  E-value: 6.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558    30 DELRERLletaidmKENIPQRNTRNSSVGSQKSDCSETRKRRSTKEGPAAKRHSGEKHRNGSREDSLEYISDDREVGSSS 109
Cdd:TIGR01642   2 DEEPDRE-------REKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRS 74

                          90       100
                  ....*....|....*....|....*....
gi 71981558   110 SQSSRTRGQPLPAMPEEEEVFDKSSSSDN 138
Cdd:TIGR01642  75 RDRPRRRSRSVRSIEQHRRRLRDRSPSNQ 103
 
Name Accession Description Interval E-value
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 223-354 1.52e-75

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 234.13  E-value: 1.52e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 223 GIGSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVeCSTDN 302
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTN-VPKTQ 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 71981558 303 FQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20519  80 LQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 230-357 1.14e-44

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 153.44  E-value: 1.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558   230 VWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTA 309
Cdd:pfam00134   2 IFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSV--PKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 71981558   310 ALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGWSLG 357
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 223-354 3.34e-38

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 136.55  E-value: 3.34e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 223 GIGSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESS-NVECSTd 301
Cdd:cd20579   7 GWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQeNVVKTR- 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 71981558 302 nFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20579  86 -LQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 251-351 1.31e-33

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 123.90  E-value: 1.31e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 251 HPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECStdNFQLVGTAALFIAAKYEEIYPPKCIDFAH 330
Cdd:cd20504  27 QPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRS--KLQLVGTACMFIAAKYEEIYPPEVEEFVY 104

                        90       100
                ....*....|....*....|.
gi 71981558 331 LTDSAFTCDNIRTMEVLIVKY 351
Cdd:cd20504 105 ITDDTYTKKQVLRMEHLVLKV 125
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 225-354 3.52e-33

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 123.03  E-value: 3.52e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 225 GSPTKVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRY-LESSNVecSTDNF 303
Cdd:cd20580   9 GNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNI--NKSML 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 71981558 304 QLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20580  87 QLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 248-350 7.49e-33

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 121.87  E-value: 7.49e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 248 LGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCID 327
Cdd:cd20507  26 LSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQV--PRKKLQLVGVTALLIASKYEEIYPPEIKD 103

                        90       100
                ....*....|....*....|...
gi 71981558 328 FAHLTDSAFTCDNIRTMEVLIVK 350
Cdd:cd20507 104 FVYITDNAYTREEILQMERDILK 126
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 358-460 3.59e-29

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 110.83  E-value: 3.59e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 358 PITSIQWLSTYLQLLGTgkkNKSDHYEEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVLFVNYEPTCAV 437
Cdd:cd20520   1 PPTPNSWLNLYLQLAQL---NPPPKENDSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLVSPDDEAI 77

                        90       100
                ....*....|....*....|...
gi 71981558 438 EKATGFMQAQLEKVIEYVEPVCR 460
Cdd:cd20520  78 EQVTGYSWEQLAPCVEWMTPFAE 100
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 251-354 1.02e-27

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 107.84  E-value: 1.02e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 251 HPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAH 330
Cdd:cd20561  29 QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSV--LRGKLQLVGTAAMLLASKFEEIYPPEVAEFVY 106

                        90       100
                ....*....|....*....|....
gi 71981558 331 LTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20561 107 ITDDTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 247-354 1.35e-27

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 107.38  E-value: 1.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 247 LLGNHPDMDDEK------RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLeSSNVeCSTDNFQLVGTAALFIAAKYEEI 320
Cdd:cd20568  23 TLPNPNYMDDQKelrwkmRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFL-SKRV-VSLNKLQLVGISALFIASKYEEV 100

                        90       100       110
                ....*....|....*....|....*....|....
gi 71981558 321 YPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20568 101 NSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 248-353 3.21e-26

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 103.87  E-value: 3.21e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 248 LGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCID 327
Cdd:cd20508  37 LEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVV--KKEKLQLLGATAILIASKFDERCPPCVDD 114

                        90       100
                ....*....|....*....|....*.
gi 71981558 328 FAHLTDSAFTCDNIRTMEVLIVKYIG 353
Cdd:cd20508 115 FLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 250-354 2.66e-25

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 101.27  E-value: 2.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 250 NHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCIDFA 329
Cdd:cd20567  45 QQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQV--PRKELQLVGVTAMLIASKYEEIWAPEVNDFV 122

                        90       100
                ....*....|....*....|....*
gi 71981558 330 HLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20567 123 YISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 259-350 5.51e-24

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 95.86  E-value: 5.51e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTC 338
Cdd:cd20536   2 RAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPV--ARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTR 79

                        90
                ....*....|..
gi 71981558 339 DNIRTMEVLIVK 350
Cdd:cd20536  80 EQICNLECIILT 91
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 242-354 7.87e-24

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 97.99  E-value: 7.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 242 RATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIY 321
Cdd:cd20560  52 RPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSV--LRGKLQLVGTAAILLASKYEEIY 129

                        90       100       110
                ....*....|....*....|....*....|...
gi 71981558 322 PPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGW 354
Cdd:cd20560 130 PPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAF 162
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 253-352 2.03e-23

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 95.94  E-value: 2.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 253 DMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVEcsTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLT 332
Cdd:cd20562  36 DITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN--RQRLQLLGVSCMLIASKYEEICAPQVEEFCYIT 113

                        90       100
                ....*....|....*....|
gi 71981558 333 DSAFTCDNIRTMEVLIVKYI 352
Cdd:cd20562 114 DNTYTKQEVLEMEIDVLNAL 133
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 245-350 1.80e-21

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 90.31  E-value: 1.80e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 245 RFLLGNhpDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPK 324
Cdd:cd20566  28 HYLDGK--EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPV--SRKKLQLVGVTALLLASKYEEMYSPE 103

                        90       100
                ....*....|....*....|....*.
gi 71981558 325 CIDFAHLTDSAFTCDNIRTMEVLIVK 350
Cdd:cd20566 104 IGDFVYITDNAYTKAQIREMEMLILK 129
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 259-350 1.21e-20

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 87.63  E-value: 1.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTC 338
Cdd:cd20565  36 RAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPV--PKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTK 113

                        90
                ....*....|..
gi 71981558 339 DNIRTMEVLIVK 350
Cdd:cd20565 114 HQIRQMEMKILR 125
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 259-354 1.40e-20

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 88.12  E-value: 1.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVEcsTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTC 338
Cdd:cd20515  56 RKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIR--KSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITL 133

                        90
                ....*....|....*.
gi 71981558 339 DNIRTMEVLIVKYIGW 354
Cdd:cd20515 134 QELLDWELLVLTKLKW 149
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 259-356 2.12e-20

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 85.84  E-value: 2.12e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTC 338
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKI--SLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSK 78

                        90
                ....*....|....*...
gi 71981558 339 DNIRTMEVLIVKYIGWSL 356
Cdd:cd20542  79 KQVLRMERRVLRRLRFDL 96
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
229-357 1.71e-18

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 87.91  E-value: 1.71e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 229 KVWSLMVKRDEIPRATRFLLGNHPDMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECStdNFQLVGT 308
Cdd:COG5024 183 DIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLE--KYQLVGI 260

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 71981558 309 AALFIAAKYEEIYPPKCIDFAHLTDSAFTCDNIRTMEVLIVKYIGWSLG 357
Cdd:COG5024 261 SALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 264-350 1.95e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 76.86  E-value: 1.95e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558    264 DWMMEVCESEKLHRETFHLAVDYVDRYLesSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDsaFTCDNIRT 343
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL--SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILR 76


                   ....*..
gi 71981558    344 MEVLIVK 350
Cdd:smart00385  77 MERLLLE 83
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 259-354 2.70e-16

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 76.18  E-value: 2.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLesSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTC 338
Cdd:cd20575  56 RKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYL--SCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISP 133

                        90
                ....*....|....*.
gi 71981558 339 DNIRTMEVLIVKYIGW 354
Cdd:cd20575 134 RQLLDWEILVLGKLKW 149
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 259-354 8.61e-15

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 70.32  E-value: 8.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYP--PKCIDFAHLTD-SA 335
Cdd:cd20528   7 RRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDI--SEDQLHLVALTCLLLAAKFEELDDniPKISDLNRYLCnSV 84

                        90
                ....*....|....*....
gi 71981558 336 FTCDNIRTMEVLIVKYIGW 354
Cdd:cd20528  85 YSKQEYLQMELLILEFFQW 103
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 259-354 9.64e-14

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 68.85  E-value: 9.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECStdNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTC 338
Cdd:cd20573  55 RKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKS--RLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRP 132

                        90
                ....*....|....*.
gi 71981558 339 DNIRTMEVLIVKYIGW 354
Cdd:cd20573 133 EELLQMELLVLNKLKW 148
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 256-344 1.68e-13

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 66.19  E-value: 1.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 256 DEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVECStdNFQLVGTAALFIAAKYEEiyppKCI----DFAHL 331
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRS--KLQLLGIACMVIATRFLG----KDIltirEAAWL 74

                        90
                ....*....|....
gi 71981558 332 TDSAFTCDNI-RTM 344
Cdd:cd20521  75 TDNTYKYEDVvRMM 88
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 259-354 1.83e-12

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 63.35  E-value: 1.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLESSNVecSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDSAFTC 338
Cdd:cd20517   6 RKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQG--TKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTN 83

                        90
                ....*....|....*.
gi 71981558 339 DNIRTMEVLIVKYIGW 354
Cdd:cd20517  84 LELINQEKDILEALKW 99
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 253-355 2.40e-12

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 64.63  E-value: 2.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 253 DMDDEKRRILIDWMMEVCESEKLHRETFHLAVDYVDRYLesSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLT 332
Cdd:cd20574  50 DIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFL--AVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYT 127

                        90       100
                ....*....|....*....|...
gi 71981558 333 DSAFTCDNIRTMEVLIVKYIGWS 355
Cdd:cd20574 128 DNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 262-345 1.58e-11

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 60.12  E-value: 1.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 262 LIDWMMEVCESEKLHRETFHLAVDYVDRYLesSNVECSTDNFQLVGTAALFIAAKYEEIyPPKCIDFAHLTDsaFTCDNI 341
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFL--SKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKEL 76


                ....
gi 71981558 342 RTME 345
Cdd:cd00043  77 RKAE 80
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 259-354 2.81e-11

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 60.02  E-value: 2.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 259 RRILIDWMMEVCESEKLHRETFHLAVDYVDRYLesSNVECSTDNF---QLVGTAALFIAAKYEEIYPPKCIDFAHLTDSA 335
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFL--SSYDLPKDKPwmlQLLAVACLSLAAKMEETDVPLLVDLQVEEPKY 79

                        90       100
                ....*....|....*....|
gi 71981558 336 -FTCDNIRTMEVLIVKYIGW 354
Cdd:cd20543  80 vFEAKTIQRMELLVLSTLEW 99
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 358-465 1.52e-09

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 55.16  E-value: 1.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 358 PITSIQWLSTYLQLlgtgkknkSDHYEEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVL--FVNYEptc 435
Cdd:cd20582   1 PVTIISWLNLYLQV--------DSLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALchFTSFE--- 69

                        90       100       110
                ....*....|....*....|....*....|
gi 71981558 436 AVEKATGFMQAQLEKVIEYVEPVCRAFAKQ 465
Cdd:cd20582  70 VVKKASGLEWDCISECVNWMVPFVRTVREC 99
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 262-355 1.06e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 49.69  E-value: 1.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 262 LIDWMMEVCESEKLHRETFHLAVDYVDRYleSSNVECSTDNFQLVGTAALFIAAKYEEIYP--PKCIDFAHLTDSAFTCD 339
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRY--CSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEE 79

                        90
                ....*....|....*.
gi 71981558 340 NIRTMEVLIVKYIGWS 355
Cdd:cd20559  80 LFIQMEMHILNTLNWD 95
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 358-457 1.39e-05

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 44.39  E-value: 1.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 358 PITSIQWLSTYLQLLgtgkknksdhY--EEQNMYVPELLRSEYLEMCKILDFLLFEIDSFTFSYRTIAAAVL--FVNYEp 433
Cdd:cd20581   1 PLTIVSWLNVYMQVA----------YlnELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALyhFSSSE- 69

                        90       100
                ....*....|....*....|....
gi 71981558 434 tcAVEKATGFMQAQLEKVIEYVEP 457
Cdd:cd20581  70 --LMQKVSGYKWCEIEECVKWMVP 91
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 263-356 2.48e-04

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 40.37  E-value: 2.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 263 IDWMMEVCESEKLHRETFHLAVDYVDRYLESsnVECSTDNFQLVGTAALFIAAKYEE----IypPKCIDFAHLTDSAFTC 338
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFLAS--VKARPKYLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSV 81

                        90
                ....*....|....*...
gi 71981558 339 DNIRTMEVLIVKYIGWSL 356
Cdd:cd20526  82 AEVLRMERIILDKLHWDL 99
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 262-354 4.05e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 36.87  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558 262 LIDWMMEVCESEKLHRETFHLAVDYVDRYLE--SSNVECSTDNFQLVGTAALFIAAKYEEIYPPKCIDFAHLTDsaFTCD 339
Cdd:cd20557   2 LRSFIARLLRRTRLSPSVVLLALVYLERLRRrlPEALLGQEGSPYRLFLVALMLASKYLDDESYSNKSWAEISG--LPVR 79

                        90
                ....*....|....*
gi 71981558 340 NIRTMEVLIVKYIGW 354
Cdd:cd20557  80 ELNAMEREFLEALDW 94
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 30-138 6.79e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 39.11  E-value: 6.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981558    30 DELRERLletaidmKENIPQRNTRNSSVGSQKSDCSETRKRRSTKEGPAAKRHSGEKHRNGSREDSLEYISDDREVGSSS 109
Cdd:TIGR01642   2 DEEPDRE-------REKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRS 74

                          90       100
                  ....*....|....*....|....*....
gi 71981558   110 SQSSRTRGQPLPAMPEEEEVFDKSSSSDN 138
Cdd:TIGR01642  75 RDRPRRRSRSVRSIEQHRRRLRDRSPSNQ 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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