NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|71983211|ref|NP_001021084|]
View 

WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-264 4.35e-20

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 4.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  43 SVSHDCS-KLWILQedssnniSLDERMVLAKWRTAIQAADISVDGKYMVAVGMN---------------------SIVYE 100
Cdd:COG2319 179 SGSDDGTvRLWDLA-------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADgtvrlwdlatgkllrtltghsGSVRS 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 101 VELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHSLSeftetdpsrSTKA 180
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---------TGKL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 181 IRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWHIEMTTPIMSITNeHTSTISALSFSPTSRHLLSGGDDAMILIY 260
Cdd:COG2319 323 LRTLTGHTGAVRSVAFS--PDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                ....
gi 71983211 261 RIPG 264
Cdd:COG2319 400 DLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-264 4.35e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 4.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  43 SVSHDCS-KLWILQedssnniSLDERMVLAKWRTAIQAADISVDGKYMVAVGMN---------------------SIVYE 100
Cdd:COG2319 179 SGSDDGTvRLWDLA-------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADgtvrlwdlatgkllrtltghsGSVRS 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 101 VELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHSLSeftetdpsrSTKA 180
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---------TGKL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 181 IRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWHIEMTTPIMSITNeHTSTISALSFSPTSRHLLSGGDDAMILIY 260
Cdd:COG2319 323 LRTLTGHTGAVRSVAFS--PDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                ....
gi 71983211 261 RIPG 264
Cdd:COG2319 400 DLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-261 3.38e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 3.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  98 VYEVELSRDAKYLAIGQLDGAIeMLYS-ENFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHSLSEFtetdpsr 176
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTI-KLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG------- 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 177 stKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWHIEMTTPIMSITnEHTSTISALSFSPTSRHLLSGGDDAM 256
Cdd:cd00200 210 --KCLGTLRGHENGVNSVAFS--PDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGT 284


                ....*
gi 71983211 257 ILIYR 261
Cdd:cd00200 285 IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 223-260 7.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 71983211    223 TPIMSITNeHTSTISALSFSPTSRHLLSGGDDAMILIY 260
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
232-260 2.38e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*....
gi 71983211   232 HTSTISALSFSPTSRHLLSGGDDAMILIY 260
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-264 4.35e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 4.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  43 SVSHDCS-KLWILQedssnniSLDERMVLAKWRTAIQAADISVDGKYMVAVGMN---------------------SIVYE 100
Cdd:COG2319 179 SGSDDGTvRLWDLA-------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADgtvrlwdlatgkllrtltghsGSVRS 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 101 VELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHSLSeftetdpsrSTKA 180
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA---------TGKL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 181 IRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWHIEMTTPIMSITNeHTSTISALSFSPTSRHLLSGGDDAMILIY 260
Cdd:COG2319 323 LRTLTGHTGAVRSVAFS--PDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                ....
gi 71983211 261 RIPG 264
Cdd:COG2319 400 DLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
76-262 4.47e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 4.47e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  76 AIQAADISVDGKYMVAV---------------------GMNSIVYEVELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYE 134
Cdd:COG2319 122 AVRSVAFSPDGKTLASGsadgtvrlwdlatgkllrtltGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 135 VHSMRIRKIEFLPNEERFLSACDDRLIKLHSLseftetdpsRSTKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQI 214
Cdd:COG2319 202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDL---------ATGKLLRTLTGHSGSVRSVAFS--PDGRLLASGSADGTV 270

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 71983211 215 FIWHIEmTTPIMSITNEHTSTISALSFSPTSRHLLSGGDDAMILIYRI 262
Cdd:COG2319 271 RLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
63-264 1.81e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.81e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  63 SLDERMVLAKWRTAIQAADISVDGKYMVAVGMNSIVYEVELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHSMRIRK 142
Cdd:COG2319  46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 143 IEFLPNEERFLSACDDRLIKLHSLseftetdpsRSTKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWHIEMT 222
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDL---------ATGKLLRTLTGHSGAVTSVAFS--PDGKLLASGSDDGTVRLWDLATG 194

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 71983211 223 TPIMSITnEHTSTISALSFSPTSRHLLSGGDDAMILIYRIPG 264
Cdd:COG2319 195 KLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-261 3.38e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 3.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  98 VYEVELSRDAKYLAIGQLDGAIeMLYS-ENFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHSLSEFtetdpsr 176
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTI-KLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG------- 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 177 stKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWHIEMTTPIMSITnEHTSTISALSFSPTSRHLLSGGDDAM 256
Cdd:cd00200 210 --KCLGTLRGHENGVNSVAFS--PDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGT 284


                ....*
gi 71983211 257 ILIYR 261
Cdd:cd00200 285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
76-267 5.12e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 5.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  76 AIQAADISVDGKYMVAV---------------------GMNSIVYEVELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYE 134
Cdd:COG2319 164 AVTSVAFSPDGKLLASGsddgtvrlwdlatgkllrtltGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 135 VHSMRIRKIEFLPNEERFLSACDDRLIKLHSLSeftetdpsrSTKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQI 214
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA---------TGELLRTLTGHSGGVNSVAFS--PDGKLLASGSDDGTV 312

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 71983211 215 FIWHIEMTTPIMSITNeHTSTISALSFSPTSRHLLSGGDDAMILIYRIPGVGE 267
Cdd:COG2319 313 RLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-262 2.85e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 2.85e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  41 MLSVSHDCS-KLWilqeDSSNNISLDERMVLAKWrtaIQAADISVDGKYMVAVGMNSI---------------------V 98
Cdd:cd00200  24 LATGSGDGTiKVW----DLETGELLRTLKGHTGP---VRDVAASADGTYLASGSSDKTirlwdletgecvrtltghtsyV 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  99 YEVELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHSLseftetdpsRST 178
Cdd:cd00200  97 SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL---------RTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 179 KAIRVYSAHDAPVTGLTIDEKsgGTRFASSSASSQIFIWHIEMTTPIMSITnEHTSTISALSFSPTSRHLLSGGDDAMIL 258
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPD--GEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDGTIR 244


                ....
gi 71983211 259 IYRI 262
Cdd:cd00200 245 VWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-262 9.14e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 9.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  79 AADISVDGKYMVAVGMNS--IVYEVE-------------------LSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHS 137
Cdd:cd00200  14 CVAFSPDGKLLATGSGDGtiKVWDLEtgellrtlkghtgpvrdvaASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 138 MRIRKIEFLPNEeRFLSAC-DDRLIKLHSLseftetdpsRSTKAIRVYSAHDAPVTGLTIdekSGGTRF-ASSSASSQIF 215
Cdd:cd00200  94 SYVSSVAFSPDG-RILSSSsRDKTIKVWDV---------ETGKCLTTLRGHTDWVNSVAF---SPDGTFvASSSQDGTIK 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 71983211 216 IWHIEMTTPIMSITnEHTSTISALSFSPTSRHLLSGGDDAMILIYRI 262
Cdd:cd00200 161 LWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
69-262 4.48e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 4.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211  69 VLAKWRTAIQAADISVDGKYMVAVGMNSIVYEVELSRDAKYLAIGQLDGAIEMLYSENFKNYHKYEVHSMRIRKIEFLPN 148
Cdd:COG2319  10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 149 EERFLSACDDRLIKLHSLSeftetdpsrSTKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWHIEMTTPIMSI 228
Cdd:COG2319  90 GRLLASASADGTVRLWDLA---------TGLLLRTLTGHTGAVRSVAFS--PDGKTLASGSADGTVRLWDLATGKLLRTL 158

                       170       180       190
                ....*....|....*....|....*....|....
gi 71983211 229 TnEHTSTISALSFSPTSRHLLSGGDDAMILIYRI 262
Cdd:COG2319 159 T-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-263 4.33e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 4.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983211 136 HSMRIRKIEFLPNEERFLSACDDRLIKLHSLSeftetdpsrSTKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIF 215
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE---------TGELLRTLKGHTGPVRDVAAS--ADGTYLASGSSDKTIR 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 71983211 216 IWHIEMTTPIMSITnEHTSTISALSFSPTSRHLLSGGDDAMILIYRIP 263
Cdd:cd00200  77 LWDLETGECVRTLT-GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 223-260 7.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 7.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 71983211    223 TPIMSITNeHTSTISALSFSPTSRHLLSGGDDAMILIY 260
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
232-260 2.38e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*....
gi 71983211   232 HTSTISALSFSPTSRHLLSGGDDAMILIY 260
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-165 2.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.83e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 71983211    126 NFKNYHKYEVHSMRIRKIEFLPNEERFLSACDDRLIKLHS 165
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-218 3.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 71983211    177 STKAIRVYSAHDAPVTGLTIDekSGGTRFASSSASSQIFIWH 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS--PDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH