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Conserved domains on  [gi|71984860|ref|NP_001021425|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

serpentine receptor domain-containing protein( domain architecture ID 27798)

serpentine receptor domain-containing protein which belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srh super family cl11665
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 8-283 4.13e-72

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10327:

Pssm-ID: 416353  Cd Length: 303  Bit Score: 224.73  E-value: 4.13e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860     8 CPYGPPDYYMKTLQLIGLFSLPINFLCFYFVWFYTPKESKFRYCLAYFQV------------------------------ 57
Cdd:pfam10327   3 IDFTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGKIDNFRYYLLYFQIsctltdihltflmqpiplfpiiagycngfl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860    58 -------------FGYFKFSFELPSLLLCFIYRHNAAANFNPKFKIRRSIQYLVIATCHTFPFVTAICLLKSELSHVQQV 124
Cdd:pfam10327  83 atvfgisshylmtIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   125 RILEkvrryklqtretanytQNWPNCLHIL-DHRGFVMYDPfdNPWTTAVGLSAMVYISVFTLFGAYVGFHTVYILQKVK 203
Cdd:pfam10327 163 EYVK----------------ENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLR 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   204 PHLSPQTYAGHKNAMINLVMQCVVPIVCVItPFNLIFLVVYYDLWQYQQSATNLFFLMSAQSMATSLVIILSNRRFKRLI 283
Cdd:pfam10327 225 KKISAQTYQKHRAALRSLIAQFATSPVCIL-PPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
 
Name Accession Description Interval E-value
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 8-283 4.13e-72

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 224.73  E-value: 4.13e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860     8 CPYGPPDYYMKTLQLIGLFSLPINFLCFYFVWFYTPKESKFRYCLAYFQV------------------------------ 57
Cdd:pfam10327   3 IDFTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGKIDNFRYYLLYFQIsctltdihltflmqpiplfpiiagycngfl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860    58 -------------FGYFKFSFELPSLLLCFIYRHNAAANFNPKFKIRRSIQYLVIATCHTFPFVTAICLLKSELSHVQQV 124
Cdd:pfam10327  83 atvfgisshylmtIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   125 RILEkvrryklqtretanytQNWPNCLHIL-DHRGFVMYDPfdNPWTTAVGLSAMVYISVFTLFGAYVGFHTVYILQKVK 203
Cdd:pfam10327 163 EYVK----------------ENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLR 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   204 PHLSPQTYAGHKNAMINLVMQCVVPIVCVItPFNLIFLVVYYDLWQYQQSATNLFFLMSAQSMATSLVIILSNRRFKRLI 283
Cdd:pfam10327 225 KKISAQTYQKHRAALRSLIAQFATSPVCIL-PPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
 
Name Accession Description Interval E-value
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 8-283 4.13e-72

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 224.73  E-value: 4.13e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860     8 CPYGPPDYYMKTLQLIGLFSLPINFLCFYFVWFYTPKESKFRYCLAYFQV------------------------------ 57
Cdd:pfam10327   3 IDFTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGKIDNFRYYLLYFQIsctltdihltflmqpiplfpiiagycngfl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860    58 -------------FGYFKFSFELPSLLLCFIYRHNAAANFNPKFKIRRSIQYLVIATCHTFPFVTAICLLKSELSHVQQV 124
Cdd:pfam10327  83 atvfgisshylmtIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   125 RILEkvrryklqtretanytQNWPNCLHIL-DHRGFVMYDPfdNPWTTAVGLSAMVYISVFTLFGAYVGFHTVYILQKVK 203
Cdd:pfam10327 163 EYVK----------------ENYPEYLSQFsSLPNFAIYDY--NPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLR 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   204 PHLSPQTYAGHKNAMINLVMQCVVPIVCVItPFNLIFLVVYYDLWQYQQSATNLFFLMSAQSMATSLVIILSNRRFKRLI 283
Cdd:pfam10327 225 KKISAQTYQKHRAALRSLIAQFATSPVCIL-PPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 13-277 2.59e-10

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 60.25  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860    13 PDYYMKTLQLIGLFSLPINFLCFYFVWFYTPKESK-FRYCLAYFQ-----------------------------VFGYFK 62
Cdd:pfam10318   3 PDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKsVKWSLLNLHfwsalldlslsfltipyiflpalagyplgLLSYLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860    63 FSFELPSLLLC-------------FIYRHNAAANfNPKFKIRRSIQYLVIATCHTFPFVTAICLLKselshvqQVRILEK 129
Cdd:pfam10318  83 VPTPIQFYIGVtslalvgvsiillFENRYSILFT-NKKRITWKKTRVLYLIFNYIIALLFLIPIYL-------NIPDQEA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   130 VRRYKLQTretanytqnWPN-CLHILDHRGFVMYDpFDNPWTTAVGLSAMVYISVFTLFgaYVGFHTVYILQKVKPHLSP 208
Cdd:pfam10318 155 AKLKVLKK---------LPClPPEFFDNPPVFVLA-IDSTYFLICIVLLILILIIQILF--FVFLTIYYLFKSVKSSLSK 222

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71984860   209 QTYAGHKNAMINLVMQCVVPIVCVITPFNLIFLVVYydLWQYQQSATNL-FFLMSAQSMATSLVIILSNR 277
Cdd:pfam10318 223 KTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSII--FGYYNQALNNLlFIIISLHGLLSTIAMLLVHK 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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